737 results on '"Lancaster K"'
Search Results
2. Prospects for high gain inertial fusion energy: an introduction to the first special edition
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Norreys, PA, Ridgers, C, Lancaster, K, Koepke, M, and Tynan, G
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Affordable and Clean Energy ,inertial confinement fusion ,inertial fusion energy ,fast ignition ,central hot spot ,direct drive ,indirect drive ,General Science & Technology - Abstract
A European consortium of 15 laboratories across nine nations have worked together under the EUROFusion Enabling Research grants for the past decade with three principle objectives. These are: (a) investigating obstacles to ignition on megaJoule-class laser facilities; (b) investigating novel alternative approaches to ignition, including basic studies for fast ignition (both electron and ion-driven), auxiliary heating, shock ignition etc.; and (c) developing technologies that will be required in the future for a fusion reactor. The Hooke discussion meeting in March 2020 provided an opportunity to reflect on the progress made in inertial confinement fusion research world-wide to date. This first edition of two special issues seeks to identify paths forward to achieve high fusion energy gain. This article is part of a discussion meeting issue 'Prospects for high gain inertial fusion energy (part 1)'.
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- 2020
3. Effects of Two Alcohol Reduction Interventions on Depression and Anxiety Symptoms of ART Clients in Vietnam
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Nguyen, M. X., Reyes, H. L., Pence, B. W., Muessig, K. E., Hutton, H. E., Latkin, C. A., Dowdy, D., Chander, G., Lancaster, K. E., Frangakis, C., Sripaipan, T., Tran, H. V., and Go, V. F.
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- 2022
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4. Prospects for high gain inertial fusion energy : an introduction to the first special edition
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Norreys, P. A., Ridgers, C., Lancaster, K., Koepke, M., and Tynan, G.
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- 2020
5. Determining the short laser pulse contrast based on X-Ray emission spectroscopy
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Martynenko, A.S., Skobelev, I.Yu., Pikuz, S.A., Ryazantsev, S.N., Baird, C., Booth, N., Doehl, L., Durey, P., Farley, D., Kodama, R., Lancaster, K., McKenna, P., Murphy, C., Spindloe, C., Pikuz, T.A., and Woolsey, N.
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- 2021
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6. Micron-Scale Mapping of Megagauss Magnetic Fields in Petawatt Laser-Solid Interactions
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Chatterjee, Gourab, Singh, Prashant Kumar, Robinson, A. P. L., Booth, N., Culfa, O., Dance, R. J., Gizzi, L. A., Gray, R. J., Green, J. S., Koester, P., Kumar, G. Ravindra, Labate, L., Lad, Amit D., Lancaster, K. L., Pasley, J., Woolsey, N. C., and Rajeev, P. P.
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Physics - Plasma Physics - Abstract
We report spatially and temporally resolved measurements of magnetic fields generated by petawatt laser-solid interactions with high spatial resolution, using optical polarimetry. The polarimetric measurements map the megagauss magnetic field profiles generated by the fast electron currents at the target rear. The magnetic fields at the rear of a 50 $\mu$m thick aluminum target exhibit distinct and unambiguous signatures of electron beam filamentation. These results are corroborated by hybrid simulations., Comment: 5 pages, 5 figures
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- 2013
7. Measuring fast electron spectra and laser absorption in relativistic laser-solid interactions using differential bremsstrahlung photon detectors
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Scott, R. H. H., Clark, E. L., Perez, F., Streeter, M. J. V, Davies, J. R., Schlenvoigt, H. -P., Santos, J. J., Hulin, S., Lancaster, K. L., Baton, S. D., Rose, S. J., and Norreys, P. A.
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Physics - Plasma Physics - Abstract
A photon detector suitable for the measurement of bremsstrahlung spectra generated in relativistically-intense laser-solid interactions is described. The Monte Carlo techniques used to back-out the fast electron spectrum and laser energy absorbed into fast electrons are detailed. A relativistically-intense laser-solid experiment using frequency doubled laser light is used to demonstrate the effective operation of the detector. The experimental data was interpreted using the 3-spatial-dimension Monte Carlo code MCNPX (Pelowitz 2008), and the fast electron temperature found to be 125 keV.
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- 2013
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8. Non-price Competition
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Lancaster, K. J. and Macmillan Publishers Ltd
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- 2018
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9. Exotic dense matter states pumped by relativistic laser plasma in the radiation dominant regime
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Colgan, J., Abdallah, Jr., J., Faenov, A. Ya., Pikuz, S. A., Wagenaars, E., Booth, N., Brown, C. R. D., Culfa, O., Dance, R. J., Evans, R. G., Gray, R. J., Hoarty, D. J., Kaempfer, T., Lancaster, K. L., McKenna, P., Rossall, A. L., Skobelev, I. Yu., Schulze, K. S., Uschmann, I., Zhidkov, A. G., and Woolsey, N. C.
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Physics - Plasma Physics ,Physics - Atomic Physics - Abstract
The properties of high energy density plasma are under increasing scrutiny in recent years due to their importance to our understanding of stellar interiors, the cores of giant planets$^{1}$, and the properties of hot plasma in inertial confinement fusion devices$^2$. When matter is heated by X-rays, electrons in the inner shells are ionized before the valence electrons. Ionization from the inside out creates atoms or ions with empty internal electron shells, which are known as hollow atoms (or ions)$^{3,4,5}$. Recent advances in free-electron laser (FEL) technology$^{6,7,8,9}$ have made possible the creation of condensed matter consisting predominantly of hollow atoms. In this Letter, we demonstrate that such exotic states of matter, which are very far from equilibrium, can also be formed by more conventional optical laser technology when the laser intensity approaches the radiation dominant regime$^{10}$. Such photon-dominated systems are relevant to studies of photoionized plasmas found in active galactic nuclei and X-ray binaries$^{11}$. Our results promote laser-produced plasma as a unique ultra-bright x-ray source for future studies of matter in extreme conditions as well as for radiography of biological systems and for material science studies$^{12,13,14,15}$.
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- 2012
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10. Separating the BL Lac and Cluster X-ray Emissions in Abell 689 with Chandra
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Giles, P. A., Maughan, B. J., Birkinshaw, M., Worrall, D. M., and Lancaster, K.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present the results of a Chandra observation of the galaxy cluster Abell 689 (z=0.279). Abell 689 is one of the most luminous clusters detected in the ROSAT All Sky Survey (RASS), but was flagged as possibly including significant point source contamination. The small PSF of the Chandra telescope allows us to confirm this and separate the point source from the extended cluster X-ray emission. For the cluster we determine a bolometric luminosity of L_{bol}=(3.3+/-0.3)x10^{44} erg s-1 and a temperature of kT=5.1^{+2.2}_{-1.3} keV when including a physically motivated background model. We compare our measured luminosity for A689 to that quoted in the Rosat All Sky Survey (RASS) and find L_{0.1-2.4,keV}=2.8x10^{44} erg s-1, a value \sim10 times lower than the ROSAT measurement. Our analysis of the point source shows evidence for significant pileup, with a pile-up fraction of ~60%. SDSS spectra and HST images lead us to the conclusion that the point source within Abell 689 is a BL Lac object. Using radio and optical observations from the VLA and HST archives, we determine {\alpha}_{ro}=0.50, {\alpha}_{ox}=0.77 and {\alpha}_{rx}=0.58 for the BL Lac, which would classify it as being of 'High-energy peak BL Lac' (HBL) type. Spectra extracted of A689 show a hard X-ray excess at energies above 6 keV that we interpret as inverse Compton emission from aged electrons that may have been transported into the cluster from the BL Lac., Comment: 11 pages, 15 figures, MNRAS in press
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- 2011
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11. A blind detection of a large, complex, Sunyaev--Zel'dovich structure
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Consortium, AMI, Shimwell, T. W., Barker, R. W., Biddulph, P., Bly, D., Boysen, R. C., Brown, A. R., Brown, M. L., Clementson, C., Crofts, M., Culverhouse, T. L., Czeres, J., Dace, R. J., Davies, M. L., D'Alessandro, R., Doherty, P., Duggan, K., Ely, J. A., Felvus, M., Feroz, F., Flynn, W., Franzen, T. M. O., Geisbusch, J., Genova-Santos, R., Grainge, K. J. B., Grainger, W. F., Hammett, D., Hobson, M. P., Holler, C. M., Hurley-Walker, N., Jilley, R., Kaneko, T., Kneissl, R., Lancaster, K., Lasenby, A. N., Marshall, P. J., Newton, F., Norris, O., Northrop, I., Odell, D. M., Olamaie, M., Pober, Y. C. Perrott J. C., Pooley, G. G., Pospieszalski, M. W., Quy, V., Rodriguez-Gonzalvez, C., Saunders, R. D. E., Scaife, A. M. M., Schammel, M. P., Schofield, J., Scott, P. F., Shaw, C., Smith, H., Titterington, D. J., Velic, M., Waldram, E. M., West, S., Wood, B. A., Yassin, G., and Zwart, J. T. L.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
We present an interesting Sunyaev-Zel'dovich (SZ) detection in the first of the Arcminute Microkelvin Imager (AMI) 'blind', degree-square fields to have been observed down to our target sensitivity of 100{\mu}Jy/beam. In follow-up deep pointed observations the SZ effect is detected with a maximum peak decrement greater than 8 \times the thermal noise. No corresponding emission is visible in the ROSAT all-sky X-ray survey and no cluster is evident in the Palomar all-sky optical survey. Compared with existing SZ images of distant clusters, the extent is large (\approx 10') and complex; our analysis favours a model containing two clusters rather than a single cluster. Our Bayesian analysis is currently limited to modelling each cluster with an ellipsoidal or spherical beta-model, which do not do justice to this decrement. Fitting an ellipsoid to the deeper candidate we find the following. (a) Assuming that the Evrard et al. (2002) approximation to Press & Schechter (1974) correctly gives the number density of clusters as a function of mass and redshift, then, in the search area, the formal Bayesian probability ratio of the AMI detection of this cluster is 7.9 \times 10^4:1; alternatively assuming Jenkins et al. (2001) as the true prior, the formal Bayesian probability ratio of detection is 2.1 \times 10^5:1. (b) The cluster mass is MT,200 = 5.5+1.2\times 10^14h-1M\odot. (c) Abandoning a physical model with num- -1.3 70 ber density prior and instead simply modelling the SZ decrement using a phenomenological {\beta}-model of temperature decrement as a function of angular distance, we find a central SZ temperature decrement of -295+36 {\mu}K - this allows for CMB primary anisotropies, receiver -15 noise and radio sources. We are unsure if the cluster system we observe is a merging system or two separate clusters., Comment: accepted MNRAS. 12 pages, 9 figures
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- 2010
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12. Controlling fast electron beam divergence using two laser pulses
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Scott, R. H. H., Beaucourt, C., Schlenvoigt, H. -P., Markey, K., Lancaster, K. L., Ridgers, C. P., Brenner, C. M., Pasley, J., Gray, R. J., Musgrave, I. O., Robinson, A. P. L, Li, K., Notley, M. M., Davies, J. R., Baton, S. D., Santos, J. J., Feugeas, J. -L., Nicolaï, Ph., Malka, G., Tikhonchuk, V. T., McKenna, P., Neely, D., Rose, S. J., and Norreys, P. A.
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Physics - Plasma Physics - Abstract
This paper describes the first experimental demonstration of the guiding of a relativistic electron beam in a solid target using two co-linear, relativistically intense, picosecond laser pulses. The first pulse creates a magnetic field which guides the higher current fast electron beam generated by the second pulse. The effects of intensity ratio, delay, total energy and intrinsic pre-pulse are examined. Thermal and K{\alpha} imaging showed reduced emission size, increased peak emission and increased total emission at delays of 4 - 6 ps, an intensity ratio of 10 : 1 (second:first) and a total energy of 186 J. In comparison to a single, high contrast shot, the inferred fast electron divergence is reduced by 2.7 times, while the fast electron current density is increased by a factor of 1.8. The enhancements are reproduced with modelling and are shown to be due to the self-generation of magnetic fields. Such a scheme could be of considerable benefit to fast ignition inertial fusion.
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- 2010
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13. One Centimetre Receiver Array-prototype observations of the CRATES sources at 30 GHz
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Peel, M. W., Gawronski, M. P., Battye, R. A., Birkinshaw, M., Browne, I. W. A., Davis, R. J., Feiler, R., Kus, A. J., Lancaster, K., Lowe, S. R., Pazderska, B. M., Pazderski, E., Roukema, B. F., and Wilkinson, P. N.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Knowledge of the population of radio sources in the range ~2-200 GHz is important for understanding their effects on measurements of the Cosmic Microwave Background power spectrum. We report measurements of the 30 GHz flux densities of 605 radio sources from the Combined Radio All-sky Targeted Eight-GHz Survey (CRATES), which have been made with the One Centimetre Receiver Array prototype (OCRA-p) on the Torun 32-m telescope. The flux densities of sources that were also observed by WMAP and previous OCRA surveys are in broad agreement with those reported here, however a number of sources display intrinsic variability. We find a good correlation between the 30 GHz and Fermi gamma-ray flux densities for common sources. We examine the radio spectra of all observed sources and report a number of Gigahertz-peaked and inverted spectrum sources. These measurements will be useful for comparison to those from the Low Frequency Instrument of the Planck satellite, which will make some of its most sensitive observations in the region covered here., Comment: 21 pages (9 pages of text, 12 pages of table), 7 figures. Erratum appended to end (page 20). Accepted by MNRAS. The definitive version is available at www.blackwell-synergy.com
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- 2010
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14. A 33 GHz VSA survey of the Galactic plane from 27 to 46 degrees
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Todorović, M., Davies, R. D., Dickinson, C., Davis, R. J., Cleary, K. A., Genova-Santos, R., Grainge, K. J. B., Hafez, Y. A., Hobson, M. P., Jones, M. E., Lancaster, K., Rebolo, R., Reich, W., Rubiño-Martin, J. A., Saunders, R. D. E., Savage, R. S., Scott, P. F., Slosar, A., Taylor, A. C., and Watson, R. A.
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Astrophysics - Astrophysics of Galaxies - Abstract
The Very Small Array (VSA) has been used to survey the l = 27 to 46 deg, |b|<4 deg region of the Galactic plane at a resolution of 13 arcmin. The survey consists of 44 pointings of the VSA, each with a r.m.s. sensitivity of ~90 mJy/beam. These data are combined in a mosaic to produce a map of the area. The majority of the sources within the map are HII regions. We investigated anomalous radio emission from the warm dust in 9 HII regions of the survey by making spectra extending from GHz frequencies to the FIR IRAS frequencies. Acillary radio data at 1.4, 2.7, 4.85, 8.35, 10.55, 14.35 and 94 GHz in addition to the 100, 60, 25 and 12 micron IRAS bands were used to construct the spectra. From each spectrum the free-free, thermal dust and anomalous dust emission were determined for each HII region. The mean ratio of 33 GHz anomalous flux density to FIR 100 micron flux density for the 9 selected HII regions was 1.10 +/-0.21x10^(-4). When combined with 6 HII regions previously observed with the VSA and the CBI, the anomalous emission from warm dust in HII regions is detected with a 33 GHz emissivity of 4.65 +/- 0.4 micro K/ (MJy/sr) at 11.5{\sigma}. The anomalous radio emission in HII regions is on average 41+/-10 per cent of the radio continuum at 33 GHz., Comment: 18 pages, 11 figures, accepted for publication in MNRAS
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- 2010
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15. 30 GHz observations of sources in the VSA fields
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Gawronski, M. P., Peel, M. W., Lancaster, K., Battye, R. A., Birkinshaw, M., Browne, I. W. A., Davies, M. L., Davis, R. J., Feiler, R., Franzen, T. M. O., Genova-Santos, R., Kus, A. J., Lowe, S. R., Pazderska, B. M., Pazderski, E., Pooley, G. G., Roukema, B. F., Waldram, E. M., and Wilkinson, P. N.
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Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
Small angular scale (high l) studies of cosmic microwave background anisotropies require accurate knowledge of the statistical properties of extragalactic sources at cm-mm wavelengths. We have used a 30 GHz dual-beam receiver (OCRA-p) on the Torun 32-m telescope to measure the flux densities of 121 sources in VSA fields selected at 15 GHz with the Ryle Telescope. We have detected 57 sources above a limiting flux density of 5mJy, of which 31 sources have a flux density greater than 10mJy, which is our effective completeness limit. From these measurements we derive a surface density of sources above 10mJy at 30 GHz of 2.0+/-0.4 per square degree. This is consistent with the surface density obtained by Mason et al. (2009) who observed a large sample of sources selected at a much lower frequency (1.4 GHz). We have also investigated the dependence of the spectral index distribution on flux density by comparing our results with those for sources above 1 Jy selected from the WMAP 22 GHz catalogue. We conclude that the proportion of steep spectrum sources increases with decreasing flux density, qualitatively consistent with the predictions of deZotti et al. (2005). We find no evidence for an unexpected population of sources whose spectra rise towards high frequencies, which would affect our ability to interpret current high resolution CMB observations at 30 GHz and above., Comment: 12 pages, 12 figures, submitted to MNRAS
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- 2009
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16. Survey of Planetary Nebulae at 30 GHz with OCRA-p
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Pazderska, B. M., Gawronski, M. P., Feiler, R., Birkinshaw, M., Browne, I. W. A., Davis, R., Kus, A. J., Lancaster, K., Lowe, S. R., Pazderski, E., Peel, M., and Wilkinson, P. N.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We report the results of a survey of 442 planetary nebulae at 30 GHz. The purpose of the survey is to develop a list of planetary nebulae as calibration sources which could be used for high frequency calibration in future. For 41 PNe with sufficient data, we test the emission mechanisms in order to evaluate whether or not spinning dust plays an important role in their spectra at 30 GHz. The 30-GHz data were obtained with a twin-beam differencing radiometer, OCRA-p, which is in operation on the Torun 32-m telescope. Sources were scanned both in right ascension and declination. We estimated flux densities at 30 GHz using a free-free emission model and compared it with our data. The primary result is a catalogue containing the flux densities of 93 planetary nebulae at 30 GHz. Sources with sufficient data were compared with a spectral model of free-free emission. The model shows that free-free emission can generally explain the observed flux densities at 30 GHz thus no other emission mechanism is needed to account for the high frequency spectra., Comment: 10 pages, 7 Postscript figures, to be published in A&A
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- 2009
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17. O011 Exploring Nocturnal Blood Pressure Surges Relationships with Brain Health and Cognitive Function.
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Bull, C, primary, Zhang, T, additional, Burke, P, additional, Butlin, M, additional, Botansky, C, additional, Srirengan, A, additional, Cysique, L, additional, Lancaster, K, additional, Brown, E, additional, Bilston, L, additional, and Jugé, L, additional
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- 2023
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18. AMiBA Observations, Data Analysis and Results for Sunyaev-Zel'dovich Effects
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Wu, J. -H. P., Ho, P. T. P., Huang, C. -W. L., Koch, P. M., Liao, Y. -W., Lin, K. -Y., Liu, G. -C., Molnar, S. M., Nishioka, H., Umetsu, K., Wang, F. -C., Altamirano, P., Birkinshaw, M., Chang, C. -H., Chang, S. -H., Chang, S. -W., Chen, M. -T., Chiueh, T., Han, C. -C., Huang, Y. -D., Hwang, Y. -J., Jiang, H., Kesteven, M., Kubo, D. Y., Lancaster, K., Li, C. -T., Martin-Cocher, P., Oshiro, P., Raffin, P., Wei, T., and Wilson, W.
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Astrophysics - Abstract
We present observations, analysis and results for the first-year operation of AMiBA, an interferometric experiment designed to study cosmology via the measurement of Cosmic Microwave Background (CMB). AMiBA is the first CMB interferometer operating at 3 mm to have reported successful results, currently with seven close-packed antennas of 60-cm diameter giving a synthesized resolution of around 6'. During 2007 AMiBA detected the Sunyaev-Zel'dovich effects (SZE) of six galaxy clusters at redshift 0.091 <= z <= 0.322. An observing strategy with on-off-source switching is used to minimize the effects from electronic offset and ground pickup. Planets were used to test the observational capability of AMiBA and to calibrate the conversion from correlator time-lag data to visibilities. The detailed formalism for data analysis is given. We summarize our early tests including observations of planets and quasars, and present images, visibility profiles, the estimated central coordinates, sizes, and SZE amplitudes of the galaxy clusters. Science results are summarized. We also discuss possible systematic effects in the results., Comment: Accepted by ApJ (Dec.23, 2008); 11 pages, 9 figures, 6 tables
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- 2008
19. The Arcminute Microkelvin Imager
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Consortium, AMI, Zwart, J. T. L., Barker, R. W., Biddulph, P., Bly, D., Boysen, R. C., Brown, A. R., Clementson, C., Crofts, M., Culverhouse, T. L., Czeres, J., Dace, R. J., Davies, M. L., D'Alessandro, R., Doherty, P., Duggan, K., Ely, J. A., Felvus, M., Feroz, F., Flynn, W., Franzen, T. M. O., Geisbüsch, J., Génova-Santos, R., Grainge, K. J. B., Grainger, W. F., Hammett, D., Hills, R. E., Hobson, M. P., Holler, C. M., Hurley-Walker, N., Jilley, R., Jones, M. E., Kaneko, T., Kneissl, R., Lancaster, K., Lasenby, A. N., Marshall, P. J., Newton, F., Norris, O., Northrop, I., Odell, D. M., Pober, J. C., Pooley, G. G., Quy, V., Rodríguez-Gonzálvez, C., Saunders, R. D. E., Scaife, A. M., Schofield, J., Scott, P. F., Shaw, C., Shimwell, T. W., Smith, H., Taylor, A. C., Titterington, D. J., Velić, M., Waldram, E. M., West, S., Wood, B. A., and Yassin, G.
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Astrophysics - Abstract
The Arcminute Microkelvin Imager is a pair of interferometer arrays operating with six frequency channels spanning 13.9-18.2 GHz, with very high sensitivity to angular scales 30''-10'. The telescope is aimed principally at Sunyaev-Zel'dovich imaging of clusters of galaxies. We discuss the design of the telescope and describe and explain its electronic and mechanical systems., Comment: 15 pages, 13 figures. Submitted to MNRAS
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- 2008
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20. Longitudinal Ion Acceleration from High-Intensity Laser Interactions with Underdense Plasma
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Willingale, L., Mangles, S. P. D., Nilson, P. M, Clarke, R. J., Dangor, A. E., Kaluza, M. C., Karsch, S., Lancaster, K. L., Mori, W. B., Schreiber, J., Thomas, A. G. R., Wei, M. S., Krushelnick, K., and Najmudin, Z.
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Physics - Plasma Physics - Abstract
Longitudinal ion acceleration from high-intensity (I ~ 10^20 Wcm^-2) laser interactions with helium gas jet targets (n_e ~ 0.04 n_c) have been observed. The ion beam has a maximum energy for He^2+ of approximately 40 MeV and was directional along the laser propagation path, with the highest energy ions being collimated to a cone of less than 10 degrees. 2D particle-in-cell simulations have been used to investigate the acceleration mechanism. The time varying magnetic field associated with the fast electron current provides a contribution to the accelerating electric field as well as providing a collimating field for the ions. A strong correlation between the plasma density and the ion acceleration was found. A short plasma scale-length at the vacuum interface was observed to be beneficial for the maximum ion energies, but the collimation appears to be improved with longer scale-lengths due to enhanced magnetic fields in the ramp acceleration region., Comment: 18 pages, 6 figures
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- 2007
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21. The Effect of Laser Focusing Conditions on Propagation and Monoenergetic Electron Production in Laser Wakefield Accelerators
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Thomas, A. G. R., Najmudin, Z., Mangles, S. P. D., Murphy, C. D., Dangor, A. E., Kamperidis, C., Lancaster, K. L., Mori, W. B., Norreys, P. A., Rozmus, W., and Krushelnick, K.
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Physics - Plasma Physics ,Physics - Accelerator Physics - Abstract
The effect of laser focusing conditions on the evolution of relativistic plasma waves in laser wakefield accelerators is studied both experimentally and with particle-in-cell simulations. For short focal length ($w_0 < \lambda_p$) interactions, beam break-up prevents stable propagation of the pulse. High field gradients lead to non-localized phase injection of electrons, and thus broad energy spread beams. However for long focal length geometries ($w_0 > \lambda_p$), a single optical filament can capture the majority of the laser energy, and self-guide over distances comparable to the dephasing length, even for these short-pulses ($c\tau \approx \lambda_p$). This allows the wakefield to evolve to the correct shape for the production of the monoenergetic electron bunches, as measured in the experiment., Comment: 4 pages, 4 figures
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- 2007
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22. High-significance Sunyaev-Zel'dovich measurement: Abell 1914 seen with the Arcminute Microkelvin Imager
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AMI Collaboration, Barker, R., Biddulph, P., Bly, D., Boysen, R., Brown, A., Clementson, C., Crofts, M., Culverhouse, T., Czeres, J., Dace, R., D'Alessandro, R., Doherty, P., Duffett-Smith, P., Duggan, K., Ely, J., Felvus, M., Flynn, W., Geisbuesch, J., Grainge, K., Grainger, W., Hammet, D., Hills, R., Hobson, M., Holler, C., Jilley, R., Jones, M., Kaneko, T., Kneissl, R., Lancaster, K., Lasenby, A., Marshall, P., Newton, F., Norris, O., Northrop, I., Pooley, G., Quy, V., Saunders, R., Scaife, A., Schofield, J., Scott, P., Shaw, C., Taylor, A., Titterington, D., Velic, M., Waldram, E., West, S., Wood, B., Yassin, G., and Zwart, J.
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Astrophysics - Abstract
We report the first detection of a Sunyaev-Zel'dovich (S-Z) decrement with the Arcminute Microkelvin Imager (AMI). We have made commissioning observations towards the cluster A1914 and have measured an integrated flux density of -8.61 mJy in a uv-tapered map with noise level 0.19 mJy/beam. We find that the spectrum of the decrement, measured in the six channels between 13.5-18GHz, is consistent with that expected for a S-Z effect. The sensitivity of the telescope is consistent with the figures used in our simulations of cluster surveys with AMI., Comment: 5 pages, 6 figures, submitted to MNRAS Letters
- Published
- 2005
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23. CMB observations from the CBI and VSA: A comparison of coincident maps and parameter estimation methods
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Rajguru, N., Myers, S. T., Battye, R. A., Bond, J. Richard, Cleary, K., Contaldi, C. R., Davies, R. D., Davis, R. J., Dickinson, C., Genova-Santos, R., Grainge, K., Hafez, Y. A., Hobson, M. P., Jones, M. E., Kneissl, R., Lancaster, K., Lasenby, A., Mason, B. S., Pearson, T. J., Pooley, G. G., Readhead, A. C. S., Rebolo, R., Rocha, G., Rubino-Martin, J. A., Saunders, R. D. E., Savage, R. S., Scaife, A., Scott, P. F., Sievers, J. L., Slosar, A., Taylor, A. C., Titterington, D., Waldram, E., Watson, R. A., and Wilkinson, A.
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Astrophysics - Abstract
We present coincident observations of the Cosmic Microwave Background (CMB) from the Very Small Array (VSA) and Cosmic Background Imager (CBI) telescopes. The consistency of the full datasets is tested in the map plane and the Fourier plane, prior to the usual compression of CMB data into flat bandpowers. Of the three mosaics observed by each group, two are found to be in excellent agreement. In the third mosaic, there is a 2 sigma discrepancy between the correlation of the data and the level expected from Monte Carlo simulations. This is shown to be consistent with increased phase calibration errors on VSA data during summer observations. We also consider the parameter estimation method of each group. The key difference is the use of the variance window function in place of the bandpower window function, an approximation used by the VSA group. A re-evaluation of the VSA parameter estimates, using bandpower windows, shows that the two methods yield consistent results., Comment: 10 pages, 6 figures. Final version. Accepted for publication in MNRAS
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- 2005
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24. Observational issues in radiometric and interferometric detection and analysis of the Sunyaev-Zel'dovich effects
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Birkinshaw, M. and Lancaster, K.
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Astrophysics - Abstract
This review discusses the techniques used in single-dish and interferometric radiometric observations of the Sunyaev-Zel'dovich effects, the pitfalls that arise, the systematic and other sources of error in the data, and the uncertainties in the interpretation of the results., Comment: 46 pages, 23 figures. To appear in Background Microwave Radiation and Intracluster Cosmology, Proceedings of the International School of Physics "Enrico Fermi", Eds. Melchiorri, F. & Rephaeli, Y., 2004
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- 2004
25. Cosmology from Cluster SZ and Weak Lensing Data
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Marshall, P. J., Lancaster, K., Hobson, M. P., and Grainge, K. J. B.
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Astrophysics - Abstract
Weak gravitational lensing and the Sunyaev-Zel'dovich effect provide complementary information on the composition of clusters of galaxies. Preliminary results from cluster SZ observations with the Very Small Array are presented. A Bayesian approach to combining this data with wide field lensing data is then outlined; this allows the relative probabilities of cluster models of varying complexity to be computed. A simple simulation is used to demonstrate the importance of cluster model selection in cosmological parameter determination., Comment: 4 pages, 4 figures, to appear in proceedings of XXXVIIth Rencontres de Moriond, "The Cosmological Model"; h-depebndence corrected, typos fixed
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- 2002
26. Comparison of Negative Pressure Wound Therapy with or without a Split-Thickness Skin Graft in the Surgical Management of Axillary Hidradenitis Suppurativa: A Retrospective Cohort Study
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Vinnicombe, Z., Singh, G. V., Spiers, J., Pouncey, A. L., McEvoy, H., and Lancaster, K.
- Abstract
Introduction:Negative pressure wound therapy (NPWT) alone or with the addition of a split-thickness skin graft (STSG) are 2 reconstructive options available after surgical excision of axillary hidradenitis suppurativa (HS). The aim of this study was to retrospectively examine patients undergoing these treatments and to assess clinical and patient-related outcome measures. Methods:A single-centre, retrospective analysis was conducted, evaluating surgical excision of axillary HS, with STSG and NPWT, or NPWT alone. Data collected included No. of post-operative clinic visits, time to heal, size of wound, disease recurrence, follow-up time, Dermatology Life Quality Index (DLQI), the Generalised Anxiety Disorder Assessment (GAD-7), the Patient Health Questionnaire Depression Scale (PHQ-9), Pain Visual Analogue Scale (PAINVAS2), the Brief Illness Perception Questionnaire (BIPQ), and Dermatology Visual Analogue Scale (DERMVAS). Two-tailed t-test and Mann–Whitney Wilcoxon U-tests were used to assess for significant relationships. Results:One hundred five patients were included in the study, 44 who received NPWT alone, and 61 who received NPWT + STSG. There was no significant difference in follow-up time (P= .934) or No. of follow-up appointments between groups (P= .287). There was a significant difference in time to heal between groups, with STSG + NPWT observing a mean time of 2.77 months and NPWT alone observing a mean time of 4.40 months (P= .0006). There was no difference in patient-reported outcomes between the 2 groups. Conclusion:There is no difference in patient-reported outcomes with the addition of an STSG to NPWT after surgical excision of HS. Wide excision and use of NPWT alone is an effective procedure for the treatment of axillary HS.
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- 2024
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27. The productive techniques and constitutive effects of ‘evidence-based policy’ and ‘consumer participation’ discourses in health policy processes
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Lancaster, K., Seear, K., Treloar, C., and Ritter, A.
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- 2017
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28. Makower, Helen (1910–1998)
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Lancaster, K. J. and Macmillan Publishers Ltd
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- 2018
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29. Alcohol use as a mediator of the effect of two alcohol reduction interventions on mental health symptoms of ART clients in Vietnam.
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Nguyen, M. X., Reyes, H. L., Pence, B. W., Muessig, K. E., Hutton, H., Latkin, C. A., Dowdy, D., Chander, G., Lancaster, K. E., Frangakis, C., Sripaipan, T., Tran, H. V., and Go, V. F.
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PREVENTION of mental depression ,ANXIETY prevention ,ALCOHOLISM treatment ,STRUCTURAL equation modeling ,CONFIDENCE intervals ,MOTIVATIONAL interviewing ,TREATMENT effectiveness ,TEMPERANCE ,ALCOHOL drinking ,QUESTIONNAIRES ,DESCRIPTIVE statistics ,PSYCHOLOGY of HIV-positive persons ,PSYCHOTHERAPY ,SECONDARY analysis ,COGNITIVE therapy - Abstract
We aimed to examine the mediating role of alcohol use in the pathway from the interventions to depression and anxiety symptoms using data from a randomized controlled trial among people living with HIV (PWH) with hazardous alcohol use (n = 440) in Thai Nguyen, Vietnam. Participants were randomized into either a combined intervention (CoI), a brief intervention (BI) and a standard of care arm. Both interventions were based on cognitive behavioral therapy and motivational enhancement therapy. Alcohol use was measured as the percentage of days abstinent from alcohol in the last 30 days. Symptoms of depression and anxiety were measured with the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 scales. Alcohol use was a significant mediator of the effects of two alcohol interventions on depression symptoms, but not anxiety symptoms. There were significant indirect effects via alcohol use of both interventions on depression symptoms at 12 months (CoI: mean difference (MD) = −0.134; 95%CI: −0.251, −0.035); (BI: MD = −0.141; 95%CI: −0.261, −0.038). There were no significant direct or total effects of the interventions on either symptoms at 12 months. Interventions with a dual focus on mental health and alcohol disorders are needed to determine optimal ways to tackle these common comorbidities among PWH. [ABSTRACT FROM AUTHOR]
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- 2023
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30. The Sunyaev–Zel’dovich Effect in Cosmology and Cluster Physics
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Birkinshaw, M., Lancaster, K., Beig, R., editor, Beiglböck, W., editor, Domcke, W., editor, Englert, B.-G., editor, Frisch, U., editor, Hänggi, P., editor, Hasinger, G., editor, Hepp, K., editor, Hillebrandt, W., editor, Imboden, D., editor, Jaffe, R. L., editor, Lipowsky, R., editor, Löhneysen, H. v., editor, Ojima, I., editor, Sornette, D., editor, Theisen, S., editor, Weise, W., editor, Wess, J., editor, Zittartz, J., editor, Plionis, Manolis, editor, Hughes, David, editor, and López-Cruz, Omar, editor
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- 2008
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31. HPA-axis hormone modulation of stress response circuitry activity in women with remitted major depression
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Holsen, L.M., Lancaster, K., Klibanski, A., Whitfield-Gabrieli, S., Cherkerzian, S., Buka, S., and Goldstein, J.M.
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- 2013
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32. Commissioning and First User Experiments with ReLaX and XFEL Beam
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(0000-0002-7671-0901) Laso García, A., Arefiev, A., Kemp, A., Allen, C. H., Bähtz, C., Nagler, B., Palmer, C. A. J., Murphy, C. D., Spindloe, C., Brown, C. R. D., Neely, D., (0000-0002-6350-4180) Kraus, D., Marley, E., Hartouni, E. P., Fiuza, F., Grim, G. P., Cochran, G. E., (0000-0003-4400-1315) Schlenvoigt, H.-P., (0000-0003-0931-1350) Prencipe, I., Williams, J., Green, J., Eggert, J. H., (0000-0003-3926-409X) Zeil, K., Lancaster, K. L., Divol, L., (0000-0002-6914-4083) Gaus, L., (0000-0003-1184-2097) Huang, L., Schoelmerich, M., (0000-0001-6200-6406) Rehwald, M., Oliver, M., Rödel, M., Macdonald, M., (0000-0002-7162-7500) Smid, M., Makita, M., Nakatsutsumi, M., (0000-0001-6748-0422) Humphries, O. S., Neumayer, P. B., Mabey, P., Shepherd, R. L., Gray, R., Wilks, S. C., Le Pape, S., Kerr, S. M., Glenzer, S. H., Funk, S., Gales, S. G., (0000-0002-5845-000X) Cowan, T., White, T. G., (0000-0003-4861-5584) Kluge, T., Doeppner, T., (0000-0001-7986-3631) Toncian, T., Zastrau, U., (0000-0003-0390-7671) Schramm, U., Ping, Y., He, Z., Höppner, H., Pelka, A., (0000-0002-7671-0901) Laso García, A., Arefiev, A., Kemp, A., Allen, C. H., Bähtz, C., Nagler, B., Palmer, C. A. J., Murphy, C. D., Spindloe, C., Brown, C. R. D., Neely, D., (0000-0002-6350-4180) Kraus, D., Marley, E., Hartouni, E. P., Fiuza, F., Grim, G. P., Cochran, G. E., (0000-0003-4400-1315) Schlenvoigt, H.-P., (0000-0003-0931-1350) Prencipe, I., Williams, J., Green, J., Eggert, J. H., (0000-0003-3926-409X) Zeil, K., Lancaster, K. L., Divol, L., (0000-0002-6914-4083) Gaus, L., (0000-0003-1184-2097) Huang, L., Schoelmerich, M., (0000-0001-6200-6406) Rehwald, M., Oliver, M., Rödel, M., Macdonald, M., (0000-0002-7162-7500) Smid, M., Makita, M., Nakatsutsumi, M., (0000-0001-6748-0422) Humphries, O. S., Neumayer, P. B., Mabey, P., Shepherd, R. L., Gray, R., Wilks, S. C., Le Pape, S., Kerr, S. M., Glenzer, S. H., Funk, S., Gales, S. G., (0000-0002-5845-000X) Cowan, T., White, T. G., (0000-0003-4861-5584) Kluge, T., Doeppner, T., (0000-0001-7986-3631) Toncian, T., Zastrau, U., (0000-0003-0390-7671) Schramm, U., Ping, Y., He, Z., Höppner, H., and Pelka, A.
- Abstract
In this presentation we provide an overview of the commissioning and first user experiment of ReLaX in combination with the XFEL beam. We will introduce the setup and laser parameters. We will show the established standard setup combining small-angle x-ray scattering (SAXS), phase-contrast imaging (PCI) and spectroscopy techniques. Finally we will show examples of the data obtained in the interaction of the ReLaX laser with targets of interested for the short-pulse laser community.
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- 2022
33. Combined Phase Contrast Imaging and Small-Angle X-Ray Scattering Diagnostic of Relativistic Plasmas at the High Energy Density Instrument at European XFEL
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(0000-0002-7671-0901) Laso García, A., Arefiev, A., Kemp, A., Allen, C. H., Bähtz, C., Nagler, B., Palmer, C. A. J., Murphy, C. D., Spindloe, C., Brown, C. R. D., Neely, D., (0000-0002-6350-4180) Kraus, D., Marley, E., Hartouni, E. P., Fiuza, F., Grim, G. P., Cochran, G. E., (0000-0003-4400-1315) Schlenvoigt, H.-P., (0000-0003-0931-1350) Prencipe, I., Williams, J., Green, J., Eggert, J. H., (0000-0003-3926-409X) Zeil, K., Lancaster, K. L., Divol, L., (0000-0002-6914-4083) Gaus, L., (0000-0003-1184-2097) Huang, L., Schoelmerich, M., (0000-0001-6200-6406) Rehwald, M., Oliver, M., Rödel, M., Macdonald, M., (0000-0002-7162-7500) Smid, M., Makita, M., Nakatsutsumi, M., (0000-0001-6748-0422) Humphries, O. S., Neumayer, P. B., Mabey, P., Shepherd, R. L., Gray, R., Wilks, S. C., Le Pape, S., Kerr, S. M., Glenzer, S. H., Funk, S., Gales, S. G., (0000-0002-5845-000X) Cowan, T., White, T. G., (0000-0003-4861-5584) Kluge, T., Doeppner, T., (0000-0001-7986-3631) Toncian, T., Zastrau, U., (0000-0003-0390-7671) Schramm, U., Ping, Y., He, Z., Höppner, H., Pelka, A., (0000-0002-7671-0901) Laso García, A., Arefiev, A., Kemp, A., Allen, C. H., Bähtz, C., Nagler, B., Palmer, C. A. J., Murphy, C. D., Spindloe, C., Brown, C. R. D., Neely, D., (0000-0002-6350-4180) Kraus, D., Marley, E., Hartouni, E. P., Fiuza, F., Grim, G. P., Cochran, G. E., (0000-0003-4400-1315) Schlenvoigt, H.-P., (0000-0003-0931-1350) Prencipe, I., Williams, J., Green, J., Eggert, J. H., (0000-0003-3926-409X) Zeil, K., Lancaster, K. L., Divol, L., (0000-0002-6914-4083) Gaus, L., (0000-0003-1184-2097) Huang, L., Schoelmerich, M., (0000-0001-6200-6406) Rehwald, M., Oliver, M., Rödel, M., Macdonald, M., (0000-0002-7162-7500) Smid, M., Makita, M., Nakatsutsumi, M., (0000-0001-6748-0422) Humphries, O. S., Neumayer, P. B., Mabey, P., Shepherd, R. L., Gray, R., Wilks, S. C., Le Pape, S., Kerr, S. M., Glenzer, S. H., Funk, S., Gales, S. G., (0000-0002-5845-000X) Cowan, T., White, T. G., (0000-0003-4861-5584) Kluge, T., Doeppner, T., (0000-0001-7986-3631) Toncian, T., Zastrau, U., (0000-0003-0390-7671) Schramm, U., Ping, Y., He, Z., Höppner, H., and Pelka, A.
- Abstract
The High Energy Density (HED) instrument at the European XFEL provides a platform to study hot and warm dense matter. The Helmholtz International Beamline for Extreme Fields (HiBEF) is a User Consortium supplying HED with two laser systems (the high-intensity ReLaX laser, by Amplitude Technologies, and the high-energy Dipole-100X laser, by STFC), Diamond Anvil Cells setup and high-pulsed magnetic fields. These tools in combination with the XFEL beam enable the investigation of relativistic laser plasmas, strong-field QED phenomena, high-pressure astro- and planetary physics as well as magnetic phenomena in condensed matter. The successful commissioning of the ultra-short pulse high-intensity ReLaX laser, provides new unique opportunities in the plasma and high-field physics fields [1]. ReLaX is a double CPA Ti:Sa laser capable of delivering up to 300 TW pulses on target. In the first commissioning phase, 100 TW pulses were used, reaching intensities up to 1020 W/cm2. Small-Angle X-Ray Scattering (SAXS) without the need of a beamstop was first commissioned at HED in September 2019. Two highly annealed pyrolytic graphite (HAPG) crystals were used to reflect the SAXS photons onto a detector while allowing the main XFEL beam to go through [2]. In April and May 2021, Small Angle X-Ray Scattering and Phase Contrast Imaging (PCI) were simultaneously demonstrated in pump-probe experiments at HED in a community experiment involving 15 institutions from all over the world. In this talk we will present the preliminary results of this community experiment probing ultrafast phenomena in a wide array of target configurations: hole boring in wires, shockwave generation in CH blocks, buried heating of a wire inside a CH medium, foam ionization and collective effects in heated foils. [1] A. Laso Garcia, H. Hoeppner, A. Pelka et al., “ReLaX: the HiBEF high-intensity short-pulse laser driver for relativistic laser-matter interaction and strong-field science at the HED instrument at Eu
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- 2022
34. Comparison of Negative Pressure Wound Therapy with or without a Split-Thickness Skin Graft in the Surgical Management of Axillary Hidradenitis Suppurativa: A Retrospective Cohort Study
- Author
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Vinnicombe, Z., primary, Singh, G. V., additional, Spiers, J., additional, Pouncey, A. L., additional, McEvoy, H., additional, and Lancaster, K., additional
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- 2022
- Full Text
- View/download PDF
35. Commissioning and First User Experiments with ReLaX and XFEL Beam
- Author
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Laso García, A., Arefiev, A., Kemp, A., Allen, C. H., Bähtz, C., Nagler, B., Palmer, C. A. J., Murphy, C. D., Spindloe, C., Brown, C. R. D., Neely, D., Kraus, D., Marley, E., Hartouni, E. P., Fiuza, F., Grim, G. P., Cochran, G. E., Schlenvoigt, H.-P., Prencipe, I., Williams, J., Green, J., Eggert, J. H., Zeil, K., Lancaster, K. L., Divol, L., Gaus, L., Huang, L., Schoelmerich, M., Rehwald, M., Oliver, M., Rödel, M., Macdonald, M., Smid, M., Makita, M., Nakatsutsumi, M., Humphries, O. S., Neumayer, P. B., Mabey, P., Shepherd, R. L., Gray, R., Wilks, S. C., Le Pape, S., Kerr, S. M., Glenzer, S. H., Funk, S., Gales, S. G., Cowan, T., White, T. G., Kluge, T., Doeppner, T., Toncian, T., Zastrau, U., Schramm, U., Ping, Y., He, Z., Höppner, H., and Pelka, A.
- Subjects
XFEL ,PCI ,SAXS ,Laser-plasma ,HiBEF - Abstract
In this presentation we provide an overview of the commissioning and first user experiment of ReLaX in combination with the XFEL beam. We will introduce the setup and laser parameters. We will show the established standard setup combining small-angle x-ray scattering (SAXS), phase-contrast imaging (PCI) and spectroscopy techniques. Finally we will show examples of the data obtained in the interaction of the ReLaX laser with targets of interested for the short-pulse laser community.
- Published
- 2022
36. Large Salmonella Enteritidis Outbreak with Prolonged Transmission Attributed to an Infected Food Handler, Texas, 2002
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Beatty, M. E., Shevick, G., Shupe-Ricksecker, K., Bannister, E., Tulu, A., Lancaster, K., Alexander, N., Zellner, D. E., Lyszkowicz, E., and Braden, C. R.
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- 2009
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37. Experimental study of fast electron propagation in compressed matter
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Vauzour, B., Santos, J.J., Batani, D., Baton, S.D., Koenig, M., Nicolaï, Ph., Perez, F., Beg, F.N., Benedetti, C., Benocci, R., Brambrink, E., Chawla, S., Coury, M., Dorchies, F., Fourment, C., Galimberti, M., Gizzi, L.A., Heathcote, R., Higginson, D.P., Honrubia, J.J., Hulin, S., Jafer, R., Jarrot, L.C., Labate, L., Lancaster, K., Köster, P., MacKinnon, A.J., McKenna, P., McPhee, A.G., Nazarov, W., Pasley, J., Ramis, R., Rhee, Y., Regan, C., Ribeyre, X., Richetta, M., Serres, F., Schlenvoigt, H.-P., Schurtz, G., Sgattoni, A., Spindloe, C., Vaisseau, X., Volpe, L., and Yahia, V.
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- 2011
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38. Characterization of Giardia lamblia genotypes in dogs from Tucson, Arizona using SSU-rRNA and β-giardin sequences
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Johansen, K. M., Castro, N. S., Lancaster, K. E., Madrid, E., Havas, A., Simms, J., and Sterling, C. R.
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- 2014
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39. Effects of Two Alcohol Reduction Interventions on Depression and Anxiety Symptoms of ART Clients in Vietnam
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Nguyen, M. X., primary, Reyes, H. L., additional, Pence, B. W., additional, Muessig, K. E., additional, Hutton, H. E., additional, Latkin, C. A., additional, Dowdy, D., additional, Chander, G., additional, Lancaster, K. E., additional, Frangakis, C., additional, Sripaipan, T., additional, Tran, H. V., additional, and Go, V. F., additional
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- 2021
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40. Making policy in emergencies – insights for routine policy making. The case example of opioid pharmacotherapy maintenance
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Mellor, R, Kearnes, M, Lancaster, K, McLauchlan, L, and Ritter, A
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- 2021
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41. Disparities in Dolutegravir Uptake Affecting Females of Reproductive Age With HIV in Low- and Middle-Income Countries After Initial Concerns About Teratogenicity : An Observational Study
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Romo, M.L., Patel, R.C., Edwards, J.K., Humphrey, J.M., Musick, B.S., Bernard, C., Maina, M.W., Brazier, E., Castelnuovo, B., Penner, J., Wyka, K., Cardoso, S.W., Ly, P.S., Kunzekwenyika, C., Cortés, C.P., Panczak, R., Kelvin, E.A., Wools-Kaloustian, K.K., Nash, D., Khol, V., Zhang, F.J., Zhao, H.X., Han, N., Lee, M.P., Li, P.C.K., Lam, W., Wong, H.Y., Kumarasamy, N., Ezhilarasi, C., Pujari, S., Joshi, K., Gaikwad, S., Chitalikar, A., Merati, T.P., Wirawan, D.N., Yuliana, F., Yunihastuti, E., Imran, D., Widhani, A., Tanuma, J., Oka, S., Nishijima, T., Choi, J.Y., Na, S., Kim, J.M., Gani, Y.M., Rudi, N.B., Azwa, I., Kamarulzaman, A., Syed Omar, S.F., Ponnampalavanar, S., Ditangco, R., Pasayan, M.K., Mationg, M.L., Chan, Y.J., Ku, W.W., Ke, E., Wu, P.C., Ng, O.T., Lim, P.L., Lee, L.S., Yap, J.K., Avihingsanon, A., Gatechompol, S., Phanuphak, P., Phadungphon, C., Kiertiburanakul, S., Phuphuakrat, A., Chumla, L., Sanmeema, N., Chaiwarith, R., Sirisanthana, T., Praparattanapan, J., Nuket, K., Khuwuwan, S., Kantipong, P., Kambua, P., Nguyen, K.V., Bui, H.V., Nguyen, D.T.H., Nguyen, D.T., Do, C.D., Ngo, A.V., Nguyen, L.T., Sohn, A.H., Ross, J.L., Petersen, B., Law, M.G., Jiamsakul, A., Bijker, R., Rupasinghe, D., Cahn, P., Cesar, C., Fink, V., Sued, O., Dell'Isola, E., Perez, H., Valiente, J., Yamamoto, C., Grinsztejn, B., Veloso, V., Luz, P., de Boni, R., Wagner, S.C., Friedman, R., Moreira, R., Pinto, J., Ferreira, F., Maia, M., de Menezes Succi, R.C., Machado, D.M., de Fátima Barbosa Gouvêa, A., Wolff, M., Rodriguez, M.F., Allendes, G., Pape, J.W., Rouzier, V., Marcelin, A., Perodin, C., Luque, M.T., Padgett, D., Madero, J.S., Ramirez, B.C., Belaunzaran, P., Vega, Y.C., Gotuzzo Herencia, José Eduardo, Mejía Cordero, Fernando Alonso, Carriquiry, G., McGowan, C.C., Shepherd, B.E., Sterling, T., Jayathilake, K., Person, A.K., Rebeiro, P.F., Castilho, J., Duda, S.N., Maruri, F., Vansell, H., Jenkins, C., Kim, A., Lotspeich, S., Pélagie, N., Gateretse, P., Munezero, J., Nitereka, V., Niyongabo, T., Twizere, C., Bukuru, H., Nahimana, T., Baransaka, E., Barasukana, P., Kabanda, E., Manirakiza, M., Ndikumwenayo, F., Biziragusenyuka, J., Munezero, A.M.M., Nforniwe, D.N., Ajeh, R., Ngamani, M.L., Dzudie, A., Mbuh, A., Amadou, D., Yone, E.W.P., Kendowo, E., Akele, C., Clever, A., Kitetele, F., Lelo, P., Tabala, M., Ekembe, C., Kaba, D., Diafouka, M., Ekat, M.H., Nsonde, D.M., Mafoua, A., Christ, M.N., Igirimbabazi, J., Ayinkamiye, N., Uwineza, P., Ndamijimana, E., Habarurema, E., Nyiraneza, M.L., Nyiransabimana, M.L., Tuyisenge, L., Shyaka, C., Kankindi, C., Uwakijijwe, B., Ingabire, M.G., Ndumuhire, J., Nyirabahutu, M.G., Muyango, F., Bihibindi, J.C., Uwamahoro, O., Ndoli, Y., Nsanzimana, S., Mugwaneza, P., Remera, E., Umumararungu, E., Rwibasira, G.N., Habimana, D.S., Gasana, J., Kanyabwisha, F., Kubwimana, G., Muhoza, B., Munyaneza, A., Murenzi, G., Musabyimana, F., Umwiza, F., Ingabire, C., Tuyisenge, P., Butera, A.M., Kabahizi, J., Rurangwa, E., Feza, R., Mukashyaka, E., Benekigeri, C., Musaninyange, J., Adedimeji, A., Anastos, K., Dilorenzo, M., Murchison, L., Ross, J., Yotebieng, M., Addison, D., Jones, H., Kulkarni, S., Tymejczyk, O., Elul, B., Cai, X., Dong, A., Hoover, D., Kim, H.-Y., Li, C., Shi, Q., Lancaster, K., Kuniholm, M., Edmonds, A., Parcesepe, A., Edwards, J., Keiser, O., Kimmel, A., Diero, L., Ayaya, S., Sang, E., Bukusi, E., Mulwa, E., Nyanaro, G., Kasozi, C., Ssemakadde, M., Bwana, M.B., Muyindike, W., Byakwaga, H., Kanyesigye, M., Semeere, A., Matovu, J.M., Nalugoda, F., Wasswa, F.X., Kazyoba, P., Mayige, M., Lyamuya, R.E., Mayanga, F., Ngonyani, K., Lwali, J., Urassa, M., Nyaga, C., Machemba, R., Yiannoutsos, C., Vreeman, R., Syvertsen, J., Kantor, R., Martin, J., Wenger, M., Cohen, C., Kulzer, J., Maartens, G., Bolton, C., Wood, R., Sipambo, N., Tanser, F., Boulle, A., Fatti, G., Mbewe, S., Singh, E., Chimbetete, C., Technau, K., Eley, B., Muhairwe, J., Rafael, I., Fox, M.P., Prozesky, H., Anderegg, N., Ballif, M., Ostinelli, C.H.D., Egger, M., Fenner, L., Haas, A., Hossmann, S., Rohner, E., Riou, J., Skrivankova, V., Smith, L., Taghavi, K., von Groote, P., Wandeler, G., Zaniewski, E., Zürcher, K., Anderson, K., Cornell, M., Davies, M.-A., Iyun, V., Johnson, L., Kassanjee, R., Kehoe, K., Kubjane, M., Maxwell, N., Nyakato, P., Patten, G., Tlali, M., Tsondai, P., de Waal, R., and International epidemiology Databases to Evaluate AIDS (IeDEA)
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Adult ,medicine.medical_specialty ,Prevention, policy, and public health ,Adolescent ,Pyridones ,Reproductive age ,HIV Infections ,Choice Behavior ,Article ,Piperazines ,chemistry.chemical_compound ,Acquired immunodeficiency syndrome (AIDS) ,Pregnancy ,Epidemiology ,Oxazines ,Internal Medicine ,Medicine ,Humans ,Maternal Health Services ,Cumulative incidence ,HIV Integrase Inhibitors ,610 Medicine & health ,Developing Countries ,Health equity ,business.industry ,HIV ,Contraceptives ,General Medicine ,Middle Aged ,medicine.disease ,Antiretroviral therapy ,Regimen ,Pharmaceutical Preparations ,chemistry ,Dolutegravir ,Observational study ,Female ,Age groups ,Safety ,business ,Heterocyclic Compounds, 3-Ring ,360 Social problems & social services ,Demography ,Cohort study - Abstract
BACKGROUND The transition to dolutegravir-containing antiretroviral therapy (ART) in low- and middle-income countries (LMICs) was complicated by an initial safety signal in May 2018 suggesting that exposure to dolutegravir at conception was possibly associated with infant neural tube defects. On the basis of additional evidence, in July 2019, the World Health Organization recommended dolutegravir for all adults and adolescents living with HIV. OBJECTIVE To describe dolutegravir uptake and disparities by sex and age group in LMICs. DESIGN Observational cohort study. SETTING 87 sites that began using dolutegravir in 11 LMICs in the Asia-Pacific; Caribbean, Central and South America network for HIV epidemiology (CCASAnet); and sub-Saharan African regions of the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. PATIENTS 134��672 patients aged 16 years or older who received HIV care from January 2017 through March 2020. MEASUREMENTS Sex, age group, and dolutegravir uptake (that is, newly initiating ART with dolutegravir or switching to dolutegravir from another regimen). RESULTS Differences in dolutegravir uptake among females of reproductive age (16 to 49 years) emerged after the safety signal. By the end of follow-up, the cumulative incidence of dolutegravir uptake among females 16 to 49 years old was 29.4% (95% CI, 29.0% to 29.7%) compared with 57.7% (CI, 57.2% to 58.3%) among males 16 to 49 years old. This disparity was greater in countries that began implementing dolutegravir before the safety signal and initially had highly restrictive policies versus countries with a later rollout. Dolutegravir uptake was similar among females and males aged 50 years or older. LIMITATION Follow-up was limited to 6 to 8 months after international guidelines recommended expanding access to dolutegravir. CONCLUSION Substantial disparities in dolutegravir uptake affecting females of reproductive age through early 2020 are documented. Although this disparity was anticipated because of country-level restrictions on access, the results highlight its extent and initial persistence. PRIMARY FUNDING SOURCE National Institutes of Health.
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42. Interventions to reduce stigma: Social norms interventions for health care workers
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Broady, T, Brener, L, Cama, E, Horwitz, R, Lancaster, K, and Treloar, C
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- 2021
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43. New Australian guidelines for the treatment of alcohol problems: an overview of recommendations
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Haber, PS, Riordan, BC, Winter, DT, Barrett, L, Saunders, J, Hides, L, Gullo, M, Manning, V, Day, CA, Bonomo, Y, Burns, L, Assan, R, Curry, K, Mooney-Somers, J, Demirkol, A, Monds, L, McDonough, M, Baillie, AJ, Clark, P, Ritter, A, Quinn, C, Cunningham, J, Lintzeris, N, Rombouts, S, Savic, M, Norman, A, Reid, S, Hutchinson, D, Zheng, C, Iese, Y, Black, N, Draper, B, Ridley, N, Gowing, L, Stapinski, L, Taye, B, Lancaster, K, Stjepanović, D, Kay-Lambkin, F, Jamshidi, N, Lubman, D, Pastor, A, White, N, Wilson, S, Jaworski, AL, Memedovic, S, Logge, W, Mills, K, Seear, K, Freeburn, B, Lea, T, Withall, A, Marel, C, Boffa, J, Roxburgh, A, Purcell-Khodr, G, Doyle, M, Conigrave, K, Teesson, M, Butler, K, Connor, J, Morley, KC, Haber, PS, Riordan, BC, Winter, DT, Barrett, L, Saunders, J, Hides, L, Gullo, M, Manning, V, Day, CA, Bonomo, Y, Burns, L, Assan, R, Curry, K, Mooney-Somers, J, Demirkol, A, Monds, L, McDonough, M, Baillie, AJ, Clark, P, Ritter, A, Quinn, C, Cunningham, J, Lintzeris, N, Rombouts, S, Savic, M, Norman, A, Reid, S, Hutchinson, D, Zheng, C, Iese, Y, Black, N, Draper, B, Ridley, N, Gowing, L, Stapinski, L, Taye, B, Lancaster, K, Stjepanović, D, Kay-Lambkin, F, Jamshidi, N, Lubman, D, Pastor, A, White, N, Wilson, S, Jaworski, AL, Memedovic, S, Logge, W, Mills, K, Seear, K, Freeburn, B, Lea, T, Withall, A, Marel, C, Boffa, J, Roxburgh, A, Purcell-Khodr, G, Doyle, M, Conigrave, K, Teesson, M, Butler, K, Connor, J, and Morley, KC
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Summary of recommendations and levels of evidence: Chapter 2: Screening and assessment for unhealthy alcohol use Screening Screening for unhealthy alcohol use and appropriate interventions should be implemented in general practice (Level A), hospitals (Level B), emergency departments and community health and welfare settings (Level C). Quantity–frequency measures can detect consumption that exceeds levels in the current Australian guidelines (Level B). The Alcohol Use Disorders Identification Test (AUDIT) is the most effective screening tool and is recommended for use in primary care and hospital settings. For screening in the general community, the AUDIT-C is a suitable alternative (Level A). Indirect biological markers should be used as an adjunct to screening (Level A), and direct measures of alcohol in breath and/or blood can be useful markers of recent use (Level B). Assessment Assessment should include evaluation of alcohol use and its effects, physical examination, clinical investigations and collateral history taking (Level C). Assessment for alcohol-related physical problems, mental health problems and social support should be undertaken routinely (GPP). Where there are concerns regarding the safety of the patient or others, specialist consultation is recommended (Level C). Assessment should lead to a clear, mutually acceptable treatment plan which specifies interventions to meet the patient’s needs (Level D). Sustained abstinence is the optimal outcome for most patients with alcohol dependence (Level C). Chapter 3: Caring for and managing patients with alcohol problems: interventions, treatments, relapse prevention, aftercare, and long term follow-up Brief interventions Brief motivational interviewing interventions are more effective than no treatment for people who consume alcohol at risky levels (Level A). Their effectiveness compared with standard care or alternative psychosocial interventions varies by treatment setting. They are most effective in prim
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44. New directions for participatory modelling in health: Redistributing expertise in relation to localised matters of concern.
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Adams, S, Rhodes, T, Lancaster, K, Adams, S, Rhodes, T, and Lancaster, K
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Participatory modelling seeks to foster stakeholder engagement to better attune models to their decision-making and policy contexts. Such approaches are increasingly advocated for use in the field of health. We review the instrumental and epistemological claims made in support of participatory modelling approaches. These accentuate participatory models as offering a better evidence-base for health policy decisions. By drawing attention to recent modelling experiments in a sector outside of health, that of water management, we outline a different way of thinking about participation and modelling. Here, the participatory model is configured in relation to matters of 'knowledge controversy', with modelling constituted as an 'evidence-making intervention' in relation to the making of science and expertise. Rather than presenting participatory models as an improved technical solution to addressing given policy problems within an evidence-based intervention approach, models are alternatively potentiated as sites for the redistribution of expertise among actor networks as they seek to engage politically in a matter of concern. This leads us to consider possible new directions for participatory modelling in the field of health.
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45. Recovery from alcohol problems in the absence of treatment: a qualitative narrative analysis
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Mellor, R, Lancaster, K, Ritter, A, Mellor, R, Lancaster, K, and Ritter, A
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Background and aims: Recovery from alcohol problems in the absence of treatment or mutual-aid is very common, but under-researched. This study explores the lives of people who had resolved their alcohol problems without treatment, seeking to situate experiences of recovery in social contexts and broader life narratives. Design: The in-depth qualitative interviews were aided by a life-history methodology that invited participants to account retrospectively for their lives. A narrative analysis was undertaken. Setting: Two major cities (Sydney and Melbourne) in Australia. Participants: People who had resolved an alcohol problem in the absence of treatment (n = 12) were recruited from the general community using convenience sampling. Measurements: Eligible participants had received ‘minimal treatment’ for an alcohol use disorder: fewer than three sessions in an outpatient treatment programme or nine sessions with mutual-aid groups (e.g. Alcoholics Anonymous), or having accessed mental health treatment for problems other than drinking at least 2 years prior or 1 year after having resolved an alcohol problem. Participants were considered to have had an alcohol use disorder if they reported two or more symptoms (DSM-V) within a 1-year period prior to the past year, using questions endorsed by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). People were considered to have resolved their alcohol use disorder by responding to the recruitment message calling for people who "used to have an alcohol problem but no longer do". The Alcohol Use Disorders Identification Test (AUDIT-C) was used to understand participant’s drinking behaviours in the past 12 months. Findings: Four different narratives were identified in the analysis. In the emancipation narrative, identity development and major changes across the life-curve were associated with separating oneself from an oppressive circumstance. In discovery narratives, art culture and other consciousness-expanding expe
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46. Examining untreated and treated alcohol problem resolution in an Australian online survey sample
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Mellor, R, Lancaster, K, Ritter, A, Mellor, R, Lancaster, K, and Ritter, A
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47. Making legitimacy: Drug user representation in United Nations drug policy settings
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Madden, A, Lancaster, K, Ritter, A, Treloar, C, Madden, A, Lancaster, K, Ritter, A, and Treloar, C
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Background: The importance of engaging people who use drugs in drug policy development is increasingly acknowledged including in recent UN documents. Little scholarly attention has been paid to ‘drug user representation’ in the global drug policy setting of the UN such as the Commission on Narcotic Drugs (CND). This paper examines ‘drug user representation’ in key UN drug policy processes over three decades. Method: A mapping process was undertaken using a corpus of publicly available documents from the UNGASS on Drugs and associated CND processes to identify relevant policy processes from 1987 to 2019 (n = 15) which were then assess for presence/absence of ‘drug user representation’. Those processes with positive evidence of ‘drug user representation’ (n = 9) were critically interrogated across three co-constitutive domains of the subjects, objects and forms of ‘drug user representation’. Results: Our analysis shows that despite calls for greater involvement, dominant UN drug policy discourses and other practices delimit both the political subjectivities available to people who use/have used drugs and their capacity to bring their voices to bear in this context. The analysis also highlights that human rights-based discourses, employed by ‘drug user representatives’, have emerged as an important practice of resistance against the problematic and delimiting power effects of existing UN discourses, governing practices and modes of engagement. Conclusions: In addition to the practices of resistance being undertaken by ‘drug user representatives’, we suggest there is a need to improve how ‘drug user representation’ is being made possible and done in the sites of UN drug policy deliberation and, that these sites should be opened for questioning. This we argue will not only have a positive impact on political legitimacy for ‘drug user representation’, but on the health and human rights of people who use/have used drugs.
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48. “A matter of time”: Evidence-making temporalities of vaccine development in the COVID-19 media landscape
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Harrison, M, Lancaster, K, Rhodes, T, Harrison, M, Lancaster, K, and Rhodes, T
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This article investigates how evidence of the safety and efficacy of COVID-19 vaccines is enacted in news media via a focus on the temporality of vaccine development. We argue that time constitutes a crucial object of and mechanism for knowledge production in such media and investigate how time comes to matter in vaccine evidence-making communication practices. In science communication on vaccine development, the vaccine object (along with the practices through which it is produced) undergoes a material-discursive shift from an imagined “rushed” product to being many years in the making and uninhibited by unnecessarily lengthy processes. In both these enactments of vaccine development, time itself is constituted as evidence of vaccine efficacy and safety. This article traces how time (performed as both calendar time and as a series of relational events) is materialized as an affective and epistemic object of evidence within public science communication by analyzing the material-discursive techniques through which temporality is enacted within news media focused on the timeline of COVID-19 vaccine development. We contend that time (as evidence) is remade through these techniques as an ontopolitical concern within the COVID-19 vaccine assemblage. We furthermore argue that science communication itself is an important actor in the hinterland of public health practices with performative effects and vital evidence-making capacities.
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- 2021
49. Falling Short of 90-90-90: How Missed Targets Govern Disease Elimination
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Bernays, S, Bourne, A, Kippax, S, Aggleton, P, Parker, R, Lancaster, K, Rhodes, T, Bernays, S, Bourne, A, Kippax, S, Aggleton, P, Parker, R, Lancaster, K, and Rhodes, T
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More often than not, global health targets are not met. In many ways, we might say that global health is governed through failure. Writing in a moment of global disruption and dis-ease in the context of the COVID-19 pandemic, and as the anticipated future of 2020 imagined in the UNAIDS 90-90-90 target becomes the past, we consider how missed targets govern disease elimination. Drawing on critical scholarship on numbering practices in the field of science and technology studies, we explore how global health targets continue to do their governing even as they appear to fall short. We argue that targets, as enumerated entities, do their work through progression and not completion, and enact disease elimination as a vague predicate. Success or failure has a latitude which makes ongoing governance and imagined futures possible. We find that the enumerated entity of the 90-90-90 target affords the possibility of a virtual elimination – even as it falls short. Missed targets do not ‘fail’ in performing anticipated progress. We tentatively propose that thinking differently about the timescapes of disease elimination and global health might be one way of extending the affordances of targets and their governing potential.
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- 2021
50. Excitable models: Projections, targets, and the making of futures without disease
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Rhodes, T, Lancaster, K, Rhodes, T, and Lancaster, K
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In efforts to control disease, mathematical models and numerical targets play a key role. We take the elimination of a viral infection as a case for exploring mathematical models as ‘evidence-making interventions’. Using interviews with mathematical modellers and implementation scientists, and focusing on the emergence of models of ‘treatment-as-prevention’ in hepatitis C control, we trace how projections detach from their calculative origins as social and policy practices. Drawing on the work of Michel Callon and others, we show that modelled projections of viral elimination circulate as ‘qualculations’, taking flight via their affects, including as anticipation. Modelled numerical targets do not need ‘actual numbers’ or precise measurements to perform their authority as evidence of viral elimination or as situated matters-of-concern. Modellers grapple with the ways that their models transform in policy and social practices, apparently beyond reasonable calculus. We highlight how practices of ‘holding-on’ to projections in relation to imaginaries of ‘evidence-based’ science entangle with the ‘letting-go’ of models beyond calculus. We conclude that the ‘virtual precision’ of models affords them fluid evidence-making potential. We imagine a different mode of modelling science in health, one more attuned to treating projections as qualculative, affective and relational, as excitable matter.
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- 2021
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