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2. Mortality and recurrent vascular events after first incident stroke: a 9-year community-based study of 0·5 million Chinese adults

Author

Chen, Yiping, Wright, Neil, Guo, Yu, Turnbull, Iain, Kartsonaki, Christiana, Yang, Ling, Bian, Zheng, Pei, Pei, Pan, Dongxia, Zhang, Yidan, Qin, Haiqiang, Wang, Yilong, Lv, Jun, Liu, Ming, Hao, Zilong, Wang, Yongjun, Yu, Canqing, Peto, Richard, Collins, Rory, Li, Liming, Clarke, Robert, Chen, Zhengming, Chen, Junshi, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Kerosi, Rene, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sohoni, Rajani, Wang, Jenny, Wang, Lin, Yang, Xiaoming, Han, Xiao, Hou, Can, Jing, Biao, Liu, Chao, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, and Qiu, Zhe

Published
2020
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3. Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Boxall, Ruth, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Yu, Kuai, Qiu, Gaokun, Wang, Chaolong, Pan, An, Liang, Liming, Hu, Frank B, and Wu, Tangchun

Published
2020
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4. Adiposity and risk of ischaemic and haemorrhagic stroke in 0·5 million Chinese men and women: a prospective cohort study

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kurmi, Om, Lewington, Sarah, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Chen, Ge, Han, Xiao, Hou, Can, Pei, Pei, Qu, Shuzhen, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Lv, Silu, Wang, Junzheng, Hou, Wei, Yin, Jiyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Mu, Huaiyi, Xu, Qinai, Dou, Meiling, Ren, Jiaojiao, Wang, Shanqing, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Zheng, Xiangyang, Li, Yilei, Li, Huimei, Wang, Yanjun, Wu, Ming, Zhou, Jinyi, Tao, Ran, Yang, Jie, Ni, Chuanming, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Zhang, Weiyuan, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Guan, Hairong, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Tang, Xuefeng, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Lv, Qiannan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixue, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Huang, Yuelong, Chen, Biyun, Yin, Li, Jin, Donghui, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Xiong, Youping, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Parish, Sarah, Holmes, Michael V, Lacey, Ben, Liu, Fang, Zhang, Zengzhi, and Walters, Robin G

Published
2018
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5. Age-specific association between blood pressure and vascular and non-vascular chronic diseases in 0·5 million adults in China: a prospective cohort study

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kurmi, Om, Lewington, Sarah, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Chen, Ge, Han, Xiao, Hou, Can, Pei, Pei, Qu, Shuzhen, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Lv, Silu, Wang, Junzheng, Hou, Wei, Yin, Jiyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Mu, Huaiyi, Xu, Qinai, Dou, Meiling, Ren, Jiaojiao, Wang, Shanqing, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Zheng, Xiangyang, Li, Yilei, Li, Huimei, Wang, Yanjun, Wu, Ming, Zhou, Jinyi, Tao, Ran, Yang, Jie, Ni, Chuanming, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Zhang, Weiyuan, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Guan, Hairong, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Tang, Xuefeng, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Lv, Qiannan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixue, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Huang, Yuelong, Chen, Biyun, Yin, Li, Jin, Donghui, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Xiong, Youping, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Lacey, Ben, Kong, Xiang Ling, and Walters, Robin G

Published
2018
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6. Smoking and smoking cessation in relation to risk of diabetes in Chinese men and women: a 9-year prospective study of 0·5 million people

Author

Chen, Junshi, Chen, Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li, Liming, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Bennett, Derrick, Boxall, Ruth, Bragg, Fiona, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Kartsonaki, Christiana, Kerosi, Rene, Lancaster, Garry, Lin, Kuang, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Bian, Zheng, Chen, Ge, Han, Xiao, Hou, Can, Pei, Pei, Qu, Shuzhen, Tan, Yunlong, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Lv, Silu, Wang, Junzheng, Hou, Wei, Yin, Jiyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Mu, Huaiyi, Xu, Qinai, Dou, Meiling, Ren, Jiaojiao, Wang, Shanqing, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Zheng, Xiangyang, Li, Yilei, Li, Huimei, Wang, Yanjun, Wu, Ming, Zhou, Jinyi, Tao, Ran, Yang, Jie, Ni, Chuanming, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Zhang, Weiyuan, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Guan, Hairong, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Tang, Xuefeng, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Lv, Qiannan, Zhang, Xukui, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixue, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Huang, Yuelong, Chen, Biyun, Yin, Li, Jin, Donghui, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Xiong, Youping, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Liu, Xin, and Wang, Kang

Published
2018
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8. Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

Author

Huang, Tao, Afzal, Shoaib, Yu, Canqing, Guo, Yu, Bian, Zheng, Yang, Ling, Millwood, Iona Y., Walters, Robin G., Chen, Yiping, Chen, Ningyu, Gao, Ruqin, Chen, Junshi, Clarke, Robert, Chen, Zhengming, Ellervik, Christina, Nordestgaard, Børge G., Lv, Jun, Li, Liming, Collins, Rory, Peto, Richard, Avery, Daniel, Boxall, Ruth, Bennett, Derrick, Chang, Yumei, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, Lin, Kuang, McDonnell, John, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Xiaoming, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Tan, Yunlong, Pang, Zengchang, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Chen, Xiaofang, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, Hu, Chen, Zhang, Xukui, Wu, Huifang, He, Pan, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, and Qiu, Zhe

Subjects
Adult, medicine.medical_specialty, lcsh:Medicine, Disease, Lower risk, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Causal effect, Vitamin D and neurology, Humans, Medicine, Vascular Diseases, 030212 general & internal medicine, Myocardial infarction, Vitamin D, Mendelian randomisation, Stroke, business.industry, Vascular disease, Confounding, lcsh:R, General Medicine, Vitamin D Deficiency, medicine.disease, Lipids, 3. Good health, Cardiovascular diseases, Population study, Gene-Environment Interaction, business, 030217 neurology & neurosurgery, Research Article
Abstract

Background Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is unclear if 25(OH)D is causally associated with cause-specific vascular disease and lipids. Therefore, we examined the causal association of 25(OH)D with myocardial infarction, stroke, ischaemic heart disease, ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, and lipid levels among both Chinese and Europeans. Methods We used a Mendelian randomisation (MR) design in the China Kadoorie Biobank, the Copenhagen City Heart Study, and the Copenhagen General Population Study. The 25(OH)D-related genetic variants in the CYP2R1 and DCHR7 genes were genotyped in 99,012 Chinese adults and 106,911 Danish adults. Results In Chinese adults, plasma 25(OH)D levels were not significantly associated with cause-specific vascular disease or mortality, with the exception of intracerebral haemorrhage (HR, 1.09 [95% CI, 1.01,1.18] per 25 nmol/L higher plasma 25(OH)D). In Europeans, plasma 25(OH)D levels were inversely associated with all types of vascular diseases and mortality. However, MR analysis did not demonstrate causal associations of genetically increased 25(OH)D levels with cause-specific vascular diseases, or mortality in both Chinese and European adults. In addition, each 25 nmol/L higher 25(OH)D was observationally associated with lower total cholesterol and low-density lipoprotein cholesterol levels, but higher high-density lipoprotein cholesterol levels. Likewise, MR analysis showed that 25(OH)D levels were not causally associated with lipids in both Chinese and European adults after Bonferroni correction. Conclusions We found no evidence to support that genetically increased 25(OH)D was associated with a lower risk of ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and lipid levels in both Chinese and European adults. These results suggest that the inverse associations of vitamin D with vascular disease could be the result of confounding. Electronic supplementary material The online version of this article (10.1186/s12916-019-1401-y) contains supplementary material, which is available to authorized users.

Published
2019

9. Outdoor temperature, blood pressure, and cardiovascular disease mortality among 23 000 individuals with diagnosed cardiovascular diseases from China

Author

Yang, Ling, Li, Liming, Lewington, Sarah, Guo, Yu, Sherliker, Paul, Bian, Zheng, Collins, Rory, Peto, Richard, Liu, Yun, Yang, Rong, Zhang, Yongrui, Li, Guangchun, Liu, Shumei, Chen, Zhengming, Li, Liming, Chen, Junshi, Collins, Rory, Peto, Richard, Chen, Zhengming, Chen, Zhengming, Lancaster, Garry, Yang, Xiaoming, Williams, Alex, Smith, Margaret, Yang, Ling, Chang, Yumei, Millwood, Iona, Chen, Yiping, Lewington, Sarah, Guo, Yu, Bian, Zheng, Hou, Can, Tan, Yunlong, Zhou, Huiyan, Pang, Zengchang, Wang, Shaojie, Zhang, Yun, Zhang, Kui, Liu, Silu, Hou, Wei, Zhao, Zhonghou, Liu, Shumei, Pang, Zhigang, Feng, Weijia, Wu, Shuling, Yang, Liqiu, Han, Huili, He, Hui, Yu, Bo, Pan, Xianhai, Wang, Shanqing, Wang, Hongmei, Hao, Xinhua, Chen, Chunxing, Lin, Shuxiong, Zheng, Xiangyang, Hu, Xiaoshu, Zhou, Minghao, Wu, Ming, Tao, Ran, Wang, Yeyuan, Hu, Yihe, Ma, Liangcai, Zhou, Renxian, Xu, Guanqun, Lu, Yan, Dong, Baiqing, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Gan, Zhigao, Xu, Jiujiu, Liu, Yun, Qing, Jingxin, Wu, Xianping, Gao, Yali, Luo, Guojin, Que, Xiangsan, Chen, Xiaofang, Ge, Pengfei, He, Jian, Ren, Xiaolan, Zhang, Hui, Mao, Enke, Li, Guanzhong, Li, Zhongxiao, He, Jun, Lei, Yulong, Wang, Xiaoping, Liu, Guohua, Zhu, Baoyu, Zhou, Gang, Feng, Shixian, Gao, Yulian, He, Tianyou, Jiang, Li, Qin, Jianhua, Sun, Huarong, Liu, Liqun, Yu, Min, Chen, Yaping, Hu, Ruying, Hu, Zhixiang, Hu, Jianjin, Qian, Yijian, Wu, Zhiying, Wang, Chunmei, Chen, Lingli, Liu, Wen, Li, Guangchun, Liu, Huilin, Long, Xiangquan, Xu, Xin, Xiong, Youping, Tan, Zhongwen, Xie, Xuqiu, Peng, Yunfang, and Jia, Weifang

Published
2015
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10. Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses

Author

Wang, Wenxiu, primary, Wang, Jingjia, additional, Lv, Jun, additional, Yu, Canqing, additional, Shao, Chunli, additional, Tang, Yida, additional, Guo, Yu, additional, Bian, Zheng, additional, Du, Huaidong, additional, Yang, Ling, additional, Millwood, Iona Y., additional, Walters, Robin G., additional, Chen, Yiping, additional, Chang, Liang, additional, Fan, Lei, additional, Chen, Junshi, additional, Chen, Zhengming, additional, Huang, Tao, additional, Li, Liming, additional, Clarke, Robert, additional, Collins, Rory, additional, Peto, Richard, additional, Walters, Robin, additional, Avery, Daniel, additional, Boxall, Ruth, additional, Bennett, Derrick, additional, Chang, Yumei, additional, Gilbert, Simon, additional, Hacker, Alex, additional, Hill, Mike, additional, Holmes, Michael, additional, Iona, Andri, additional, Kartsonaki, Christiana, additional, Kerosi, Rene, additional, Kong, Ling, additional, Kurmi, Om, additional, Lancaster, Garry, additional, Lewington, Sarah, additional, Lin, Kuang, additional, McDonnell, John, additional, Millwood, Iona, additional, Nie, Qunhua, additional, Radhakrishnan, Jayakrishnan, additional, Ryder, Paul, additional, Sansome, Sam, additional, Schmidt, Dan, additional, Sherliker, Paul, additional, Sohoni, Rajani, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Wang, Jenny, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Xiaoming, additional, Han, Xiao, additional, Hou, Can, additional, Pei, Pei, additional, Liu, Chao, additional, Tan, Yunlong, additional, Pang, Zengchang, additional, Gao, Ruqin, additional, Li, Shanpeng, additional, Wang, Shaojie, additional, Liu, Yongmei, additional, Du, Ranran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Zhang, Hua, additional, Zhai, Yaoming, additional, Ning, Feng, additional, Sun, Xiaohui, additional, Li, Feifei, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Zeng, Mingyuan, additional, Jiang, Ge, additional, Zhou, Xue, additional, Yang, Liqiu, additional, He, Hui, additional, Yu, Bo, additional, Li, Yanjie, additional, Xu, Qinai, additional, Kang, Quan, additional, Guo, Ziyan, additional, Wang, Dan, additional, Hu, Ximin, additional, Chen, Jinyan, additional, Fu, Yan, additional, Fu, Zhenwang, additional, Wang, Xiaohuan, additional, Weng, Min, additional, Guo, Zhendong, additional, Wu, Shukuan, additional, Li, Yilei, additional, Li, Huimei, additional, Fu, Zhifang, additional, Wu, Ming, additional, Zhou, Yonglin, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Su, Jian, additional, liu, Fang, additional, Zhang, Jun, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Tang, Zhenzhu, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Jiang, Qilian, additional, Lan, Jian, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Ping Wang, Ningyu Chen, additional, Meng, Fanwen, additional, Qin, Yulu, additional, Wang, Sisi, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Zhou, Weiwei, additional, Luo, Guojin, additional, Li, Jianguo, additional, Zhong, Xunfu, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Xiaoping, additional, Wang, Tao, additional, zhang, Xi, additional, Zhang, Ding, additional, Zhou, Gang, additional, Feng, Shixian, additional, Gao, Yulian, additional, He, Tianyou, additional, Sun, Huarong, additional, He, Pan, additional, Hu, Chen, additional, Zhang, Xukui, additional, Wu, Huifang, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Qian, Yijian, additional, Wang, Chunmei, additional, Xie, Kaixu, additional, Chen, Lingli, additional, Zhang, Yidan, additional, Pan, Dongxia, additional, Gu, Qijun, additional, Huang, Yuelong, additional, Chen, Biyun, additional, Yin, Li, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Qiaohua, additional, Xu, Xin, additional, Zhang, Hao, additional, Long, Huajun, additional, Li, Xianzhi, additional, Zhang, Libo, additional, and Qiu, Zhe, additional

Published
2021
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11. Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Author

Bakker, Mark K., van der Spek, Rick A.A., van Rheenen, Wouter, Morel, Sandrine, Bourcier, Romain, Hostettler, Isabel C., Alg, Varinder S., van Eijk, Kristel R., Koido, Masaru, Akiyama, Masato, Terao, Chikashi, Matsuda, Koichi, Walters, Robin G., Lin, Kuang, Li, Liming, Millwood, Iona Y., Chen, Zhengming, Rouleau, Guy A., Zhou, Sirui, Rannikmäe, Kristiina, Sudlow, Cathie L.M., Houlden, Henry, van den Berg, Leonard H., Dina, Christian, Naggara, Olivier, Gentric, Jean-Christophe, Shotar, Eimad, Eugène, François, Desal, Hubert, Winsvold, Bendik S., Børte, Sigrid, Johnsen, Marianne Bakke, Brumpton, Ben M., Sandvei, Marie Søfteland, Willer, Cristen J., Hveem, Kristian, Zwart, John-Anker, Verschuren, W. M. Monique, Friedrich, Christoph M., Hirsch, Sven, Schilling, Sabine, Dauvillier, Jérôme, Martin, Olivier, Martinsen, Amy E, Aamodt, Anne Hege, Skogholt, Anne Heidi, Sandset, Else Charlotte, Kristoffersen, Espen S, Ellekjaer, Hanne, Heuch, Ingrid, Nielsen, Jonas Bille, Hagen, Knut, Fritsche, Lars, Thomas, Laurent F., Pedersen, Linda, Gabrielsen, Maiken E, Vigeland, Maria Dehli, Holmen, Oddgeir, Zhou, Wei, Chen, Junshi, Chen (PI), Zhengming, Clarke, Robert, Collins, Rory, Guo, Yu, Li (PI), Liming, Liu, Depei, Lv, Jun, Peto, Richard, Walters, Robin, Avery, Daniel, Boxall, Ruth, Bennett, Derrick, Chang, Yumei, Chen, Yiping, Du, Huaidong, Gan, Wei, Gilbert, Simon, Hacker, Alex, Hill, Michael, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Lancaster, Garry, Lewington, Sarah, McDonnell, John, Millwood, Iona, Nie, Qunhua, Ryder, Paul, Sansome, Sam, Schmidt-Valle, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Lin, Wright, Neil, Yang, Ling, Yang, Xiaoming, Yao, Pang, Bian, Zheng, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Yu, Canqing, Pang, Zengchang, Gao, Ruqin, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zou, Mingyuan, Yan, Shichun, Zhou, Xue, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Chen, Jinyan, Fu, Yan, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Hua, Yujie, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Wang, Ping, Meng, Fanwen, Qin Sisi Wang, Yulu, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhou, Ding Zhang, Zhou, Gang, Feng, Shixian, Chang, Ling, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, He, Pan, Hu, Chen, Zhang, Xukui, Wu, Huifang, Yu, Min, Hu, Ruying, Wang, Hao, Gong, Weiwei, Wang, Meng, Xie, Kaixu, Chen, Lingli, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Zhang, Libo, Nagai, Akiko, Muto, Kaori, Hirata, Makoto, Morisaki, Takayuki, Yamashita, Yasushi, Kamatani, Yoichiro, Kambara, Yoko, Murakami, Yoshinori, Masumoto, Akihide, Nagayama, Satoshi, Miki, Yoshio, Yoshimori, Kozo, Fujioka, Tomoaki, Takata, Ryo, Yamaji, Ken, Takahashi, Kazuhisa, Asai, Satoshi, Takahashi, Yasuo, Minami, Shiro, Yamaguchi, Hiroki, Koretsune, Yukihiro, Nishizawa, Yasuko, Kodama, Ken, Kutsumi, Hiromu, Suzuki, Takao, Sinozaki, Nobuaki, Murayama, Shigeo, Furukawa, Yoichi, Yamanashi, Yuji, Papagiannaki, Chrisanthi, Piotin, Michel, Trystram, Denis, Edjlali-Goujon, Myriam, Boulouis, Grégoire, Rodriguez, Christine, Hassen, Waghi Ben, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Levrier, Olivier, Aguettaz, Pierre, Combaz, Xavier, Pasco, Anne, l’Allinec, Vincent, Bintner, Marc, Molho, Marc, Pascale, Gauthier, Chivot, Cyril, Costalat, Vincent, Darganzil, Cyril, Bonafé, Alain, Januel, Anne Christine, Michelozzi, Caterina, Cognard, Christophe, Bonneville, Fabrice, Tall, Philippe, Darcourt, Jean, Biondi, Alessandra, Iosif, Cristina, Ferre, Jean Christophe, Gauvrit, Jean Yves, Eugene, François, Raoult, Hélène, Gentric, Jean Christophe, Ognard, Julien, Anxionnat, René, Gory, Benjamin, Bracard, Serge, Derelle, Anne Laure, Tonnelet, Romain, Spelle, Laurent, Ikka, Léon, Ozanne, Augustin, Gallas, Sophie, Caroff, Jildaz, Achour, Nidal Ben, Moret, Jacques, Chabert, Emmanuel, Berge, Jérôme, Marnat, Gaultier, Barreau, Xavier, Gariel, Florent, Clarencon, Frédéric, Aggour, Mohammed, Ricolfi, Frédéric, Chavent, Adrien, Thouant, Pierre, Lebidinsky, Pablo, Lemogne, Brivael, Herbreteau, Denis, Bibi, Richard, Janot, Kevin, Pierot, Laurent, Soize, Sébastien, Labeyrie, Marc Antoine, Vandendries, Christophe, Kazemi, Appoline, Leclerc, Xavier, Pruvo, Jean Pierre, Bricout, Nicolas, Velasco, Stéphane, Boucebci, Samy, Lemmens, Robin, Pandolfo, Massimo, Bodenant, Marie, Louillet, Fabien, Mas, Jean-Louis, Deltour, Sandrine, Leder, Sara, Léger, Anne, Canaple, Sandrine, Godefroy, Olivier, Giroud, Maurice, Jacquin, Agnès, Moulin, Thierry, Vuillier, Fabrice, Tzourio, Christophe, Santos, Michael Dos, Malik, Rainer, Hausser, Ingrid, Thomas-Feles, Constanze, Weber, Ralf, Grond-Ginsbach, Caspar, Hacke, Werner, Giossi, Alessia, Volonghi, Irene, Costa, Paolo, del Zotto, Elisabetta, Morotti, Andrea, Poli, Loris, Muiesan, Maria Lorenza, Salvetti, Massimo, Rosei, Enrico Agabiti, Lanfranconi, Silvia, Baron, Pierluigi, Ferrarese, Carlo, Susani, Emanuela, Giacalone, Giacomo, Paolucci, Stefano, Palmirotta, Raffaele, Guadagni, Fiorella, Paciaroni, Maurizio, Ballabio, Elena, Parati, Eugenio A., Fluri, Felix, Hatz, Florian, Gisler, Dominique, Amort, Margareth, Bevan, Steve, James, Tom, Olsson, Sandra, Holmegaard, Lukas, Altintas, Ayse, Martin, Juan José, Kittner, Steven, Mitchell, Braxton, Stine, Colin, O’Connell, Jeff, Dueker, Nicole, Koudstaal, Peter J., de Lau, Lonneke M.L., Hofman, Albert, Verhaaren, Benjamin F, Uitterlinden, Andre G, Montaner, Joan, Mendioroz, Maite, Yadav, Sunaina, Khan, Muhammad Saleem, Wilder, Michael, van Dijk, Ewoud, Maaijwee, Noortje, Rutten-Jacobs, Loes, Kramer, Jamie, Malik, Shaneela, Brott, Thomas G, Brown, Robert D, Singleton, Andrew, Hardy, John, Rich, Stephen S, Tanislav, Christian, Jungehülsing, Jan, Werring, David, Alg, Varinder, Hostettler, Isabel, Bonner, Stephen, Walsh, Daniel, Bulters, Diederik, Kitchen, Neil, Brown, Martin, Grieve, Joan, Roberts, Gareth, Jones, Timothy, Critchley, Giles, Sharma, Pankaj, Nelson, Richard, Whitfield, Peter, Ross, Stuart, Patel, Hiren, Eldridge, Paul, Saastamoinen, Kari, Patel, Umang, Lawrance, Enas, Vandabona, Subha, Mendelow, David, Teal, Rachel, Warner, Orlando, Kirkpatrick, Peter, Seshadri, Sudha, Kilarski, Laura, Hyacinth, Hyacinth I, Oliveira, Jamary, Marini, Sandro, Nyquist, Paul, Lewis, Cathryn, Norrving, Bo, Smith, Gustav, Rosand, Jonathan, Biffi, Alessandro, Kourkoulis, Christina, Anderson, Chris, Giese, Anne-Katrin, Bang, Oh Young, Chung, Jong-Won, Kim, Gyeong-Moon, Zhuang, Qishuai, Sheu, Wayne, Smalley, June, Howson, Joanna, Granata, Alessandra, Markus, Hugh, Wardlaw, Joanna, Cole, John, Thalamuthu, Anbupalam, Hopewell, Jemma, Worrall, Bradford, Bis, Josh, Tirschwell, David, Reiner, Alex, Dhar, Raj, Lee, Jin-Moo, Mortenson, Janne, Wassertheil-Smoller, Sylvia, Prasad, Kameshwar, Fisher, Mark, Traenka, Christopher, Wang, Xingwu, Wang, Yongjun, Rouanet, Francois, Sibon, Igor, Sarnowski, Chloé, Maillard, Pauline, Aparicio, Hugo Javier, Dupuis, Josee, Yang, Qiong, Luvizutto, Gustavo, Chasman, Daniel, Rexrode, Kathryn, Harriot, Andrea, Phuah, Chia-Ling, Santo, Gustavo, Gerard, Jen, Liu, Guiyou, Aaron, Sanjith, Christudass, Christhunesa S., Salomi, BSB, Sanghera, Dharambir, Boehme, Amelia, Elkind, Mitchell, Gretarsdottir, Solveig, Lange, Leslie, Rost, Natalia, James, Michael, Stewart, Jill, Goldstein, Larry, Waddy, Salina, Vojinovic, Dina, Ikram, Arfan, Thijs, Vincent, Parati, Eugenio, Boncoraglio, Giorgio, Kooperberg, Charles, Abboud, Sherrine, Zand, Ramin, Bijlenga, Philippe, Selim, Magdy, Happola, Olli, Strbian, Daniel, Tomppo, Liisa, Pathak, Abhishek, Pfeiffer, Dorothea, Aires, de Buenos, de Carvalho, Joao Jose Freitas, Ribeiro, Priscila, Torres, Nuria, Barboza, Miguel, Plomaritoglou, Androniki, Bjorkegren, Johan, Chan, Yu-Feng Yvonne, Gudnason, Villi, Jimenez-Conde, Jordi, Soriano, Carolina, Roquer, Jaume, Bentley, Paul, Tournier-Lasserve, Elisabeth, Dufouil, Carole, Debette, Stephanie, Mishra, Aniket, Wee, Lawrence, Siddiqi, Saima, Wu, Jer-Yuarn, Ko, Tai-Ming, Bione, Silvia, Jood, Katarina, Tatlisumak, Turgut, Arauz, Antonio, Korostynski, Michal, Launer, Lenore, Yue, Suo, bersano, anna, Juchniewicz, Karol Józef, Mateusz, Adamski, Pera, Joanna, Wnuk, Marcin, Levi, Christopher, Gusdon, Aaron, Kostulas, Konstantinos, Maxwell, Jessye, Duering, Marco, Jagiella, Jeremiasz, Hata, Jun, Ninomiya, Toshiharu, Nguyen, Vinh, Thorarinsson, Bjorn Logi, Lee, Tsong-Hai, Rakitko, Alexandr, Dichgans, Martin, Lindgren, Arne, Wasselius, Johan, Drake, Mattias, Stenman, Martin, Ilinca, Andreea, Staals, Julie, Sadr-Nabavi, Ariane, Crawford, Katherine, Lena, Umme, Mateen, Farrah, Ay, Hakan, Wu, Ona, Schirmer, Markus, Romero, Javier, Cramer, Steve, Golland, Polina, Mueller, Bertram, Brown, Robert, Meschia, James, Ross, Owen A., Pare, Guillaume, Chong, Mike, mansour, Ossama yassin, Karaszewski, Bartosz, Enzinger, Christian, Schmidt, Reinhold, Seiler, Stephan, Pichler, Alexander, Ovbiagele, Bruce, Yamada, Yoshiji, Rundek, Tatjana, Blanton, Susan, P, John, Chern, Joseph, O'Donnell, Chris, Corriveau, Roderick, Bhattacharya, Pallab, Gwinn, Katrina, CHANDRA, BHARATENDU, Chen, Christopher, Kalaria, Raj, Koenig, Jim, Singh, Om Prakash, Olugbodi, Akintomi, Giralt, Eva, Saleheen, Danish, de Leeuw, Frank-Erik, Klijn, Karin, Olesen, Jes, Kubo, Michiaki, Spence, David, Pedersen, Annie, Olsson, Maja, Martín, Juan José, Braga, Gabriel, Xu, Huichun, Assimes, Tim, Raskurazhev, Anton, Lee, Wei Ling, Burri, Philippe, Frid, Petrea, GmbH, Heilbronn, Deng, Zhen, Habibi-koolaee, Mahdi, Vijayan, Murali, Leung, Thomas, Wong, Lawrence, Mok, Vincent, Choy, Richard, Jern, Christina, Lebedeva, Elena, Farrall, Martin, Jiayuan, Xu, Loo, Keat Wei, Rinkel, Gabriel, Magnus, Rudolf, Goncalves, Anderson, Franca, Paulo, Cendes, Iscia, Carrera, Caty, Fernandez-Cadenas, Israel, Kim, Helen, Rolfs, Arndt, Owolabi, Mayowa, Bakker, Mark, Ruigrok, Ynte, Hauer, Allard, Pulit, Sara L., Algra, Ale, van der Laan, Sander W., Macleod, Mary, Howard, George, Tiwari, Hemant, Irvin, Ryan, Albright, Karen C., Perry, Rodney, Kidwell, Chelsea, Pavlovic, Aleksandra, Sargurupremraj, Murali, Schilling, Sabrina, Pezzini, Alessandro, Abd-Allah, Foad, DeCarli, Charles, Liebeskind, David, Traylor, Matthew, Tan, Rhea, Danesh, John, Larsson, Susanna C., Rutten, Loes, Donatti, Amanda, Avelar, Wagner, Broderick, Joseph, Woo, Daniel, Kissela, Brett, Ibenez, Laura Garcia, Salman, Rustam, Sudlow, Cathie, McDonough, Caitrin Wheeler, Silliman, Scott, Magvanjav, Oyunbileg, van Agtmael, Tom, Walters, Matthew, Lorentzen, Erik, Stanne, Tara, Olsson, Martina, Nakagawa, Kazuma, Akinyemi, Rufus, Cotlatciuc, Ioana, O'Connell, Jeff, Sparks, Mary, Sorkin, John, Dave, Tushar, Naylor, Jill, Brown, Devin, Du, Rose, Kulik, Tobias B., Attia, John, Faber, James E, Rothwell, Peter, Márquez, Elsa Valdés, Mancuso, Michelangelo, Souza, Doralina Brum, de Silva, Ranil, Vibo, Riina, Korv, Janika, Maguire, Jane, Fornage, Myriam, Illoh, Kachikwu, Milewicz, Dianna, Majersik, Jennifer, DeHavenon, Adam, Kalani, Yashar, Alexander, Matthew, Cushman, Mary, Sale, Michele, Owens, Debra, Keene, Keith, Rich, Stephe, Psaty, Bruce, Longstreth, Will, Atadzhanov, Masharip, Wolfe, Stacey Quintero, Langefeld, Carl, Bushnell, Cheryl, Cruchaga, Carlos, Konrad, Jan, Liu, Junfeng, Sheth, Kevin, Falcone, Guido, Donahue J, Kathleen, Jones, Gregory T., Bown, Matthew J., Ko, Nerissa U., Coleman, Jonathan R.I., Breen, Gerome, Zaroff, Jonathan G., Klijn, Catharina J.M., Sargurupremraj, Muralidharan, Amouyel, Philippe, Debette, Stéphanie, Rinkel, Gabriel J.E., Worrall, Bradford B., Slowik, Agnieszka, Gaál-Paavola, Emilia I., Niemelä, Mika, Jääskeläinen, Juha E., von Und Zu Fraunberg, Mikael, Lindgren, Antti, Broderick, Joseph P., Werring, David J., Redon, Richard, Veldink, Jan H., Ruigrok, Ynte M., Stroke, HUNT All-In, Group, China Kadoorie Biobank Collaborative, Consortium, BioBank Japan Project, Group, ICAN Study, Group, CADISP, investigators, Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study, (ISGC), International Stroke Genetics Consortium, Morel, Sandrine, and Bijlenga, Philippe Alexandre Pierre

Subjects
genetics [Blood Pressure], Medizin, Genome-wide association study, Blood Pressure, Disease, ddc:616.07, Bioinformatics, 616: Innere Medizin und Krankheiten, 0302 clinical medicine, Risk Factors, physiopathology [Hypertension], genetics [Genetic Predisposition to Disease], Genetic risk factor, Stroke, 0303 health sciences, Smoking, genetics [Smoking], genetics [Intracranial Aneurysm], Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], Cerebrovascular disorder, 3. Good health, genetics [European Continental Ancestry Group], Hypertension, genetics [Polymorphism, Single Nucleotide], Subarachnoid hemorrhage, pathology [Intracranial Aneurysm], genetics [White People], Biology, Genetic correlation, pathology [Endothelial Cells], Polymorphism, Single Nucleotide, Article, White People, 03 medical and health sciences, Aneurysm, Asian People, ddc:570, Genetics, medicine, Humans, Genetic Predisposition to Disease, cardiovascular diseases, 030304 developmental biology, genetics [Subarachnoid Hemorrhage], genetics [Asian Continental Ancestry Group], 572: Biochemie, genetics [Asian People], pathology [Subarachnoid Hemorrhage], adverse effects [Smoking], Endothelial Cells, Subarachnoid Hemorrhage, medicine.disease, Intracranial aneurysm, Genetic architecture, ddc:616.8, Case-Control Studies, genetics [Hypertension], 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

An author correction to this article published in December 2020 is available at https://doi.org/10.1038/s41588-020-00760-4. Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asian ancestry. We discovered 17 risk loci, 11 of which are new. We reveal a polygenic architecture and explain over half of the disease heritability. We show a high genetic correlation between ruptured and unruptured intracranial aneurysms. We also find a suggestive role for endothelial cells by using gene mapping and heritability enrichment. Drug-target enrichment shows pleiotropy between intracranial aneurysms and antiepileptic and sex hormone drugs, providing insights into intracranial aneurysm pathophysiology. Finally, genetic risks for smoking and high blood pressure, the two main clinical risk factors, play important roles in intracranial aneurysm risk, and drive most of the genetic correlation between intracranial aneurysms and other cerebrovascular traits.

Published
2021

12. Alcohol consumption in 0.5 million people from 10 diverse regions of China: prevalence, patterns and socio-demographic and health-related correlates

Author

Millwood, Iona Y, Li, Liming, Smith, Margaret, Guo, Yu, Yang, Ling, Bian, Zheng, Lewington, Sarah, Whitlock, Gary, Sherliker, Paul, Collins, Rory, Chen, Junshi, Peto, Richard, Wang, Hongmei, Xu, Jiujiu, He, Jian, Yu, Min, Liu, Huilin, Chen, Zhengming, Li, Liming, Chen, Zhengming, Chen, Junshi, Collins, Rory, Wu, Fan, Peto, Richard, Chen, Zhengming, Lancaster, Garry, Yang, Xiaoming, Williams, Alex, Smith, Margaret, Yang, Ling, Chang, Yumei, Millwood, Iona, Chen, Yiping, Zhang, Qiuli, Lewington, Sarah, Whitlock, Gary, Guo, Yu, Zhao, Guoqing, Bian, Zheng, Wu, Lixue, Hou, Can, Pang, Zengchang, Wang, Shaojie, Zhang, Yun, Zhang, Kui, Liu, Silu, Zhao, Zhonghou, Liu, Shumei, Pang, Zhigang, Feng, Weijia, Wu, Shuling, Yang, Liqiu, Han, Huili, He, Hui, Pan, Xianhai, Wang, Shanqing, Wang, Hongmei, Hao, Xinhua, Chen, Chunxing, Lin, Shuxiong, Hu, Xiaoshu, Zhou, Minghao, Wu, Ming, Wang, Yeyuan, Hu, Yihe, Ma, Liangcai, Zhou, Renxian, Xu, Guanqun, Dong, Baiqing, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Gan, Zhigao, Xu, Jiujiu, Liu, Yun, Wu, Xianping, Gao, Yali, Zhang, Ningmei, Luo, Guojin, Que, Xiangsan, Chen, Xiaofang, Ge, Pengfei, He, Jian, Ren, Xiaolan, Zhang, Hui, Mao, Enke, Li, Guanzhong, Li, Zhongxiao, He, Jun, Liu, Guohua, Zhu, Baoyu, Zhou, Gang, Feng, Shixian, Gao, Yulian, He, Tianyou, Jiang, Li, Qin, Jianhua, Sun, Huarong, Liu, Liqun, Yu, Min, Chen, Yaping, Hu, Zhixiang, Hu, Jianjin, Qian, Yijian, Wu, Zhiying, Chen, Lingli, Liu, Wen, Li, Guangchun, Liu, Huilin, Long, Xiangquan, Xiong, Youping, Tan, Zhongwen, Xie, Xuqiu, and Peng, Yunfang

Published
2013
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13. Cooking fuels and risk of all-cause and cardiopulmonary mortality in urban China: a prospective cohort study

Author

Yu, Kuai, primary, Lv, Jun, additional, Qiu, Gaokun, additional, Yu, Canqing, additional, Guo, Yu, additional, Bian, Zheng, additional, Yang, Ling, additional, Chen, Yiping, additional, Wang, Chaolong, additional, Pan, An, additional, Liang, Liming, additional, Hu, Frank B, additional, Chen, Zhengming, additional, Li, Liming, additional, Wu, Tangchun, additional, Chen, Junshi, additional, Clarke, Robert, additional, Collins, Rory, additional, Peto, Richard, additional, Walters, Robin, additional, Avery, Daniel, additional, Boxall, Ruth, additional, Chang, Yumei, additional, Du, Huaidong, additional, Gilbert, Simon, additional, Hacker, Alex, additional, Hill, Mike, additional, Holmes, Michael, additional, Iona, Andri, additional, Kartsonaki, Christiana, additional, Kerosi, Rene, additional, Kong, Ling, additional, Kurmi, Om, additional, Lancaster, Garry, additional, Lewington, Sarah, additional, Lin, Kuang, additional, McDonnell, John, additional, Millwood, Iona, additional, Nie, Qunhua, additional, Radhakrishnan, Jayakrishnan, additional, Ryder, Paul, additional, Sansome, Sam, additional, Schmidt, Dan, additional, Sherliker, Paul, additional, Sohoni, Rajani, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Wang, Jenny, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Xiaoming, additional, Han, Xiao, additional, Hou, Can, additional, Pei, Pei, additional, Liu, Chao, additional, Tan, Yunlong, additional, Pang, Zengchang, additional, Gao, Ruqin, additional, Li, Shanpeng, additional, Wang, Shaojie, additional, Liu, Yongmei, additional, Du, Ranran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Zhang, Hua, additional, Zhai, Yaoming, additional, Ning, Feng, additional, Sun, Xiaohui, additional, Li, Feifei, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Zeng, Mingyuan, additional, Jiang, Ge, additional, Zhou, Xue, additional, Yang, Liqiu, additional, He, Hui, additional, Yu, Bo, additional, Li, Yanjie, additional, Xu, Qinai, additional, Kang, Quan, additional, Guo, Ziyan, additional, Wang, Dan, additional, Hu, Ximin, additional, Wang, Hongmei, additional, Chen, Jinyan, additional, Fu, Yan, additional, Fu, Zhenwang, additional, Wang, Xiaohuan, additional, Weng, Min, additional, Guo, Zhendong, additional, Wu, Shukuan, additional, Li, Yilei, additional, Li, Huimei, additional, Fu, Zhifang, additional, Wu, Ming, additional, Zhou, Yonglin, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Su, Jian, additional, Liu, Fang, additional, Zhang, Jun, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Tang, Zhenzhu, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Jiang, Qilian, additional, Lan, Jian, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Chen, Ningyu, additional, Wang, Ping, additional, Meng, Fanwen, additional, Qin, Yulu, additional, Wang, Sisi, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Zhou, Weiwei, additional, Luo, Guojin, additional, Li, Jianguo, additional, Zhong, Xunfu, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Xiaoping, additional, Wang, Tao, additional, Zhang, Xi, additional, Zhang, Ding, additional, Zhou, Gang, additional, Feng, Shixian, additional, Chang, Liang, additional, Fan, Lei, additional, Gao, Yulian, additional, He, Tianyou, additional, Sun, Huarong, additional, He, Pan, additional, Hu, Chen, additional, Zhang, Xukui, additional, Wu, Huifang, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Qian, Yijian, additional, Wang, Chunmei, additional, Xie, Kaixu, additional, Chen, Lingli, additional, Zhang, Yidan, additional, Pan, Dongxia, additional, Gu, Qijun, additional, Huang, Yuelong, additional, Chen, Biyun, additional, Yin, Li, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Qiaohua, additional, Xu, Xin, additional, Zhang, Hao, additional, Long, Huajun, additional, Li, Xianzhi, additional, Zhang, Libo, additional, and Qiu, Zhe, additional

Published
2020
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14. Vitamin D and cause-specific vascular disease and mortality:a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

Author

Huang, Tao, Afzal, Shoaib, Yu, Canqing, Guo, Yu, Bian, Zheng, Yang, Ling, Millwood, Iona Y., Walters, Robin G., Chen, Yiping, Chen, Ningyu, Gao, Ruqin, Chen, Junshi, Clarke, Robert, Chen, Zhengming, Ellervik, Christina, Nordestgaard, Børge G., Lv, Jun, Li, Liming, Collins, Rory, Peto, Richard, Avery, Daniel, Boxall, Ruth, Bennett, Derrick, Chang, Yumei, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, Lin, Kuang, McDonnell, John, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Xiaoming, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Tan, Yunlong, Pang, Zengchang, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Chen, Xiaofang, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, Hu, Chen, Zhang, Xukui, Wu, Huifang, He, Pan, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, Qiu, Zhe, Huang, Tao, Afzal, Shoaib, Yu, Canqing, Guo, Yu, Bian, Zheng, Yang, Ling, Millwood, Iona Y., Walters, Robin G., Chen, Yiping, Chen, Ningyu, Gao, Ruqin, Chen, Junshi, Clarke, Robert, Chen, Zhengming, Ellervik, Christina, Nordestgaard, Børge G., Lv, Jun, Li, Liming, Collins, Rory, Peto, Richard, Avery, Daniel, Boxall, Ruth, Bennett, Derrick, Chang, Yumei, Du, Huaidong, Gilbert, Simon, Hacker, Alex, Hill, Mike, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, Lin, Kuang, McDonnell, John, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Turnbull, Iain, Wang, Jenny, Wang, Lin, Wright, Neil, Yang, Xiaoming, Han, Xiao, Hou, Can, Pei, Pei, Liu, Chao, Tan, Yunlong, Pang, Zengchang, Li, Shanpeng, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Zhai, Yaoming, Ning, Feng, Sun, Xiaohui, Li, Feifei, Lv, Silu, Wang, Junzheng, Hou, Wei, Zeng, Mingyuan, Jiang, Ge, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Xu, Qinai, Kang, Quan, Guo, Ziyan, Wang, Dan, Hu, Ximin, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Weng, Min, Guo, Zhendong, Wu, Shukuan, Li, Yilei, Li, Huimei, Fu, Zhifang, Wu, Ming, Zhou, Yonglin, Zhou, Jinyi, Tao, Ran, Yang, Jie, Su, Jian, Liu, Fang, Zhang, Jun, Hu, Yihe, Lu, Yan, Ma, Liangcai, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Liu, Jingchao, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Lan, Jian, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Wang, Ping, Meng, Fanwen, Qin, Yulu, Wang, Sisi, Wu, Xianping, Zhang, Ningmei, Zhou, Weiwei, Luo, Guojin, Li, Jianguo, Chen, Xiaofang, Zhong, Xunfu, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Zhang, Xi, Zhang, Ding, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Sun, Huarong, Hu, Chen, Zhang, Xukui, Wu, Huifang, He, Pan, Yu, Min, Hu, Ruying, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixu, Chen, Lingli, Zhang, Yidan, Pan, Dongxia, Gu, Qijun, Huang, Yuelong, Chen, Biyun, Yin, Li, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, Zhang, Hao, Long, Huajun, Li, Xianzhi, Zhang, Libo, and Qiu, Zhe

Abstract

Background: Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is unclear if 25(OH)D is causally associated with cause-specific vascular disease and lipids. Therefore, we examined the causal association of 25(OH)D with myocardial infarction, stroke, ischaemic heart disease, ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, and lipid levels among both Chinese and Europeans. Methods: We used a Mendelian randomisation (MR) design in the China Kadoorie Biobank, the Copenhagen City Heart Study, and the Copenhagen General Population Study. The 25(OH)D-related genetic variants in the CYP2R1 and DCHR7 genes were genotyped in 99,012 Chinese adults and 106,911 Danish adults. Results: In Chinese adults, plasma 25(OH)D levels were not significantly associated with cause-specific vascular disease or mortality, with the exception of intracerebral haemorrhage (HR, 1.09 [95% CI, 1.01,1.18] per 25 nmol/L higher plasma 25(OH)D). In Europeans, plasma 25(OH)D levels were inversely associated with all types of vascular diseases and mortality. However, MR analysis did not demonstrate causal associations of genetically increased 25(OH)D levels with cause-specific vascular diseases, or mortality in both Chinese and European adults. In addition, each 25 nmol/L higher 25(OH)D was observationally associated with lower total cholesterol and low-density lipoprotein cholesterol levels, but higher high-density lipoprotein cholesterol levels. Likewise, MR analysis showed that 25(OH)D levels were not causally associated with lipids in both Chinese and European adults after Bonferroni correction. Conclusions: We found no evidence to support that genetically increased 25(OH)D was associated with a lower risk of ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and lipid levels in both Chinese and European

Published
2019

15. Carotid Intima‐Media Thickness but Not Carotid Artery Plaque in Healthy Individuals Is Linked to Lean Body Mass

Author

Arnold, Matthew, primary, Linden, Andrew, additional, Clarke, Robert, additional, Guo, Yu, additional, Du, Huaidong, additional, Bian, Zheng, additional, Wan, Eric, additional, Yang, Meng, additional, Wang, Liang, additional, Chen, Yuexin, additional, Chen, Jianwei, additional, Long, Huajun, additional, Gu, Qijun, additional, Collins, Rory, additional, Li, Liming, additional, Chen, Zhengming, additional, Parish, Sarah, additional, Chen, Junshi, additional, Lv, Jun, additional, Peto, Richard, additional, Walters, Robin, additional, Bennett, Derrick, additional, Boxall, Ruth, additional, Bragg, Fiona, additional, Chang, Yumei, additional, Chen, Yiping, additional, Gilbert, Simon, additional, Hacker, Alex, additional, Holmes, Michael, additional, Kartsonaki, Christiana, additional, Kerosi, Rene, additional, Lancaster, Garry, additional, Lin, Kuang, additional, McDonnell, John, additional, Millwood, Iona, additional, Nie, Qunhua, additional, Yao, Pang, additional, Ryder, Paul, additional, Sansome, Sam, additional, Schmidt, Dan, additional, Sohoni, Rajani, additional, Turnbull, Iain, additional, Wang, Jenny, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Ling, additional, Yang, Xiaoming, additional, Han, Xiao, additional, Hou, Can, additional, Jing, Biao, additional, Liu, Chao, additional, Pei, Pei, additional, Tan, Yunlong, additional, Yu, Canqing, additional, Gao, Ruqin, additional, Li, Shanpeng, additional, Wang, Shaojie, additional, Liu, Yongmei, additional, Du, Ranran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Zhang, Hua, additional, Zhai, Yaoming, additional, Ning, Feng, additional, Sun, Xiaohui, additional, Li, Feifei, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Zeng, Mingyuan, additional, Jiang, Ge, additional, Yang, Liqiu, additional, He, Hui, additional, Yu, Bo, additional, Li, Yanjie, additional, Xu, Qinai, additional, Kang, Quan, additional, Wang, Dan, additional, Hu, Ximin, additional, Wang, Hongmei, additional, Chen, Jinyan, additional, Fu, Yan, additional, Fu, Zhenwang, additional, Wang, Xiaohuan, additional, Weng, Min, additional, Guo, Zhendong, additional, Wu, Shukuan, additional, Li, Yilei, additional, Li, Huimei, additional, Fu, Zhifang, additional, Wu, Ming, additional, Zhou, Yonglin, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Su, Jian, additional, Liu, Fang, additional, Zhang, Jun, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Tang, Zhenzhu, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Jiang, Qilian, additional, Lan, Jian, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Chen, Ningyu, additional, Wang, Ping, additional, Meng, Fanwen, additional, Qin, Yulu, additional, Wang, Sisi, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Zhou, Weiwei, additional, Luo, Guojin, additional, Li, Jianguo, additional, Zhong, Xunfu, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Xiaoping, additional, Wang, Tao, additional, Zhang, Xi, additional, Zhang, Ding, additional, Zhou, Gang, additional, Feng, Shixian, additional, Chang, Liang, additional, Fan, Lei, additional, Gao, Yulian, additional, He, Tianyou, additional, Sun, Huarong, additional, He, Pan, additional, Hu, Chen, additional, Zhang, Xukui, additional, Wu, Huifang, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Qian, Yijian, additional, Wang, Chunmei, additional, Xie, Kaixu, additional, Chen, Lingli, additional, Zhang, Yidan, additional, Pan, Dongxia, additional, Huang, Yuelong, additional, Chen, Biyun, additional, Yin, Li, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Qiaohua, additional, Xu, Xin, additional, Zhang, Hao, additional, Li, Xianzhi, additional, Zhang, Libo, additional, and Qiu, Zhe, additional

Published
2019
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16. Solid Fuel Use and Risks of Respiratory Diseases. A Cohort Study of 280,000 Chinese Never-Smokers

Author

Chan, Ka Hung, primary, Kurmi, Om P., additional, Bennett, Derrick A., additional, Yang, Ling, additional, Chen, Yiping, additional, Tan, Yunlong, additional, Pei, Pei, additional, Zhong, Xunfu, additional, Chen, Jianxin, additional, Zhang, Jun, additional, Kan, Haidong, additional, Peto, Richard, additional, Lam, Kin Bong Hubert, additional, Chen, Zhengming, additional, Chen, Junshi, additional, Clarke, Robert, additional, Collins, Rory, additional, Guo, Yu, additional, Li, Liming, additional, Lv, Jun, additional, Walters, Robin, additional, Avery, Daniel, additional, Bennett, Derrick, additional, Boxall, Ruth, additional, Chang, Yumei, additional, Du, Huaidong, additional, Gilbert, Simon, additional, Hacker, Alex, additional, Holmes, Michael, additional, Kartsonaki, Christiana, additional, Kerosi, Rene, additional, Lancaster, Garry, additional, Lin, Kuang, additional, McDonnell, John, additional, Millwood, Iona, additional, Nie, Qunhua, additional, Radhakrishnan, Jayakrishnan, additional, Ryder, Paul, additional, Sansome, Sam, additional, Schmidt, Dan, additional, Sohoni, Rajani, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Wang, Jenny, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Xiaoming, additional, Bian, Zheng, additional, Han, Xiao, additional, Hou, Can, additional, Liu, Chao, additional, Jing, Biao, additional, Yu, Canqing, additional, Pang, Zengchang, additional, Gao, Ruqin, additional, Li, Shanpeng, additional, Wang, Shaojie, additional, Liu, Yongmei, additional, Du, Ranran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Zhang, Hua, additional, Zhai, Yaoming, additional, Ning, Feng, additional, Sun, Xiaohui, additional, Li, Feifei, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Zeng, Mingyuan, additional, Jiang, Ge, additional, Zhou, Xue, additional, Yang, Liqiu, additional, He, Hui, additional, Yu, Bo, additional, Li, Yanjie, additional, Xu, Qinai, additional, Kang, Quan, additional, Guo, Ziyan, additional, Wang, Dan, additional, Hu, Ximin, additional, Wang, Hongmei, additional, Chen, Jinyan, additional, Fu, Yan, additional, Fu, Zhenwang, additional, Wang, Xiaohuan, additional, Weng, Min, additional, Guo, Zhendong, additional, Wu, Shukuan, additional, Li, Yilei, additional, Li, Huimei, additional, Fu, Zhifang, additional, Wu, Ming, additional, Zhou, Yonglin, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Su, Jian, additional, Liu, Fang, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Tang, Zhenzhu, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Jiang, Qilian, additional, Lan, Jian, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Chen, Ningyu, additional, Wang, Ping, additional, Meng, Fanwen, additional, Qin, Yulu, additional, Wang, Sisi, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Zhou, Weiwei, additional, Luo, Guojin, additional, Li, Jianguo, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Xiaoping, additional, Wang, Tao, additional, Zhang, Xi, additional, Zhang, Ding, additional, Zhou, Gang, additional, Feng, Shixian, additional, Chang, Liang, additional, Fan, Lei, additional, Gao, Yulian, additional, He, Tianyou, additional, Sun, Huarong, additional, Hu, Chen, additional, Zhang, Xukui, additional, Wu, Huifang, additional, He, Pan, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Qian, Yijian, additional, Wang, Chunmei, additional, Xie, Kaixu, additional, Chen, Lingli, additional, Zhang, Yidan, additional, Pan, Dongxia, additional, Gu, Qijun, additional, Huang, Yuelong, additional, Chen, Biyun, additional, Yin, Li, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Qiaohua, additional, Xu, Xin, additional, Zhang, Hao, additional, Long, Huajun, additional, Li, Xianzhi, additional, Zhang, Libo, additional, and Qiu, Zhe, additional

Published
2019
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17. Breastfeeding and the Risk of Maternal Cardiovascular Disease: A Prospective Study of 300 000 Chinese Women

Author

Peters, Sanne A. E., Yang, Ling, Guo, Yu, Chen, Yiping, Bian, Zheng, Du, Jianwei, Yang, Jie, Li, Shanpeng, Li, Liming, Woodward, Mark, Chen, Zhengming, Chen, Junshi, Collins, Rory, Peto, Richard, Bennett, Derrick, Chang, Yumei, Clarke, Robert, Du, Huaidong, Fan, Xuejuan, Gilbert, Simon, Hacker, Alex, Holmes, Michael, Iona, Andri, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Kurmi, Om, Lancaster, Garry, Lewington, Sarah, McDonnell, John, Millwood, Iona, Nie, Qunhua, Radhakrishnan, Jayakrishnan, Rafiq, Sajjad, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Turnbull, Iain, Walters, Robin, Wang, Jenny, Wang, Lin, Yang, Xiaoming, Chen, Ge, Han, Bingyang, Hou, Can, Lv, Jun, Pei, Pei, Qu, Shuzhen, Tan, Yunlong, Yu, Canqing, Zhou, Huiyan, Pang, Zengchang, Gao, Ruqin, Wang, Shaojie, Liu, Yongmei, Du, Ranran, Zang, Yajing, Cheng, Liang, Tian, Xiaocao, Zhang, Hua, Lv, Silu, Wang, Junzheng, Hou, Wei, Yin, Jiyuan, Jiang, Ge, Liu, Shumei, Pang, Zhigang, Zhou, Xue, Yang, Liqiu, He, Hui, Yu, Bo, Li, Yanjie, Mu, Huaiyi, Xu, Qinai, Dou, Meiling, Ren, Jiaojiao, Wang, Shanqing, Hu, Ximin, Wang, Hongmei, Chen, Jinyan, Fu, Yan, Fu, Zhenwang, Wang, Xiaohuan, Dong, Hua, Weng, Min, Zheng, Xiangyang, Li, Yijun, Li, Huimei, Li, Chenglong, Wu, Ming, Zhou, Jinyi, Tao, Ran, Shen, Jie, Hu, Yihe, Lu, Yan, Gao, Yan, Ma, Liangcai, Zhou, Renxian, Tang, Aiyu, Zhang, Shuo, Jin, Jianrong, Tang, Zhenzhu, Chen, Naying, Huang, Ying, Li, Mingqiang, Meng, Jinhuai, Pan, Rong, Jiang, Qilian, Qing, Jingxin, Zhang, Weiyuan, Liu, Yun, Wei, Liuping, Zhou, Liyuan, Chen, Ningyu, Yang, Jun, Guan, Hairong, Wu, Xianping, Zhang, Ningmei, Chen, Xiaofang, Tang, Xuefeng, Luo, Guojin, Li, Jianguo, Wang, Jian, Liu, Jiaqiu, Sun, Qiang, Ge, Pengfei, Ren, Xiaolan, Dong, Caixia, Zhang, Hui, Mao, Enke, Wang, Xiaoping, Wang, Tao, Liu, Guohua, Zhu, Baoyu, Zhou, Gang, Feng, Shixian, Chang, Liang, Fan, Lei, Gao, Yulian, He, Tianyou, Jiang, Li, Sun, Huarong, He, Pan, Hu, Chen, Lv, Qiannan, Zhang, Xukui, Yu, Min, Hu, Ruying, Fang, Le, Wang, Hao, Qian, Yijian, Wang, Chunmei, Xie, Kaixue, Chen, Lingli, Pan, Yaxing, Pan, Dongxia, Huang, Yuelong, Chen, Biyun, Jin, Donghui, Liu, Huilin, Fu, Zhongxi, Xu, Qiaohua, Xu, Xin, g, Youping, Jia, Weifang, Li, Xianzhi, Zhang, Libo, and Qiu, Zhe

Subjects
Adult, medicine.medical_specialty, Pediatrics, China, Time Factors, Epidemiology, breastfeeding, Breastfeeding, Lower risk, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, cardiovascular disease, Risk Factors, medicine, Humans, 030212 general & internal medicine, Prospective Studies, Risk factor, Prospective cohort study, Stroke, Original Research, Aged, Proportional Hazards Models, 030219 obstetrics & reproductive medicine, business.industry, Proportional hazards model, Incidence, Hazard ratio, Age Factors, Middle Aged, Protective Factors, medicine.disease, Prognosis, 3. Good health, Breast Feeding, risk factor, Cardiovascular Diseases, Female, women, Cardiology and Cardiovascular Medicine, business
Abstract

Background Breastfeeding confers substantial benefits to child health and has also been associated with lower risk of maternal cardiovascular diseases ( CVDs ) in later life. However, the evidence on the effects of CVD is still inconsistent, especially in East Asians, in whom the frequency and duration of breastfeeding significantly differ from those in the West. Methods and Results In 2004–2008, the nationwide China Kadoorie Biobank recruited 0.5 million individuals aged 30 to 79 years from 10 diverse regions across China. During 8 years of follow‐up, 16 671 incident cases of coronary heart disease and 23 983 cases of stroke were recorded among 289 573 women without prior CVD at baseline. Cox regression yielded adjusted hazard ratios ( HR s) and 95% CIs for incident CVD by breastfeeding. Overall, ≈99% of women had given birth, among whom 97% reported a history of breastfeeding, with a median duration of 12 months per child. Compared with parous women who had never breastfed, ever breastfeeding was associated with a significantly lower risk of CVD , with adjusted HR s of 0.91 (95% CI, 0.84–0.99) for coronary heart disease and 0.92 (95% CI, 0.85–0.99) for stroke. Women who had breastfed for ≥24 months had an 18% ( HR, 0.82; 0.77–0.87) lower risk of coronary heart disease and a 17% ( HR, 0.83; 0.79–0.87) lower risk of stroke compared with women who had never breastfed. Among women who ever breastfed, each additional 6 months of breastfeeding per child was associated with an adjusted HR of 0.96 (95% CI, 0.94–0.98) for coronary heart disease and 0.97 (95% CI, 0.96–0.98) for stroke. Conclusions Among Chinese women, a history of breastfeeding was associated with an ≈10% lower risk of CVD in later life and the magnitude of the inverse association was stronger among those with a longer duration of breastfeeding.

Published
2017

18. Age-specific association between blood pressure and vascular and non-vascular chronic diseases in 0·5 million adults in China: a prospective cohort study

Author

Lacey, Ben, primary, Lewington, Sarah, additional, Clarke, Robert, additional, Kong, Xiang Ling, additional, Chen, Yiping, additional, Guo, Yu, additional, Yang, Ling, additional, Bennett, Derrick, additional, Bragg, Fiona, additional, Bian, Zheng, additional, Wang, Shaojie, additional, Zhang, Hua, additional, Chen, Junshi, additional, Walters, Robin G, additional, Collins, Rory, additional, Peto, Richard, additional, Li, Liming, additional, Chen, Zhengming, additional, Lv, Jun, additional, Walters, Robin, additional, Avery, Daniel, additional, Boxall, Ruth, additional, Chang, Yumei, additional, Du, Huaidong, additional, Gilbert, Simon, additional, Hacker, Alex, additional, Holmes, Michael, additional, Iona, Andri, additional, Kartsonaki, Christiana, additional, Kerosi, Rene, additional, Kurmi, Om, additional, Lancaster, Garry, additional, Lin, Kuang, additional, McDonnell, John, additional, Millwood, Iona, additional, Nie, Qunhua, additional, Radhakrishnan, Jayakrishnan, additional, Ryder, Paul, additional, Sansome, Sam, additional, Schmidt, Dan, additional, Sherliker, Paul, additional, Sohoni, Rajani, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Wang, Jenny, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Xiaoming, additional, Chen, Ge, additional, Han, Xiao, additional, Hou, Can, additional, Pei, Pei, additional, Qu, Shuzhen, additional, Tan, Yunlong, additional, Yu, Canqing, additional, Pang, Zengchang, additional, Gao, Ruqin, additional, Liu, Yongmei, additional, Du, Ranran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Yin, Jiyuan, additional, Jiang, Ge, additional, Zhou, Xue, additional, Yang, Liqiu, additional, He, Hui, additional, Yu, Bo, additional, Li, Yanjie, additional, Mu, Huaiyi, additional, Xu, Qinai, additional, Dou, Meiling, additional, Ren, Jiaojiao, additional, Wang, Shanqing, additional, Hu, Ximin, additional, Wang, Hongmei, additional, Chen, Jinyan, additional, Fu, Yan, additional, Fu, Zhenwang, additional, Wang, Xiaohuan, additional, Weng, Min, additional, Zheng, Xiangyang, additional, Li, Yilei, additional, Li, Huimei, additional, Wang, Yanjun, additional, Wu, Ming, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Ni, Chuanming, additional, Zhang, Jun, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Tang, Zhenzhu, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Jiang, Qilian, additional, Zhang, Weiyuan, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Chen, Ningyu, additional, Guan, Hairong, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Tang, Xuefeng, additional, Luo, Guojin, additional, Li, Jianguo, additional, Zhong, Xunfu, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Xiaoping, additional, Wang, Tao, additional, Zhang, Xi, additional, Zhang, Ding, additional, Zhou, Gang, additional, Feng, Shixian, additional, Chang, Liang, additional, Fan, Lei, additional, Gao, Yulian, additional, He, Tianyou, additional, Sun, Huarong, additional, He, Pan, additional, Hu, Chen, additional, Lv, Qiannan, additional, Zhang, Xukui, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Qian, Yijian, additional, Wang, Chunmei, additional, Xie, Kaixue, additional, Chen, Lingli, additional, Zhang, Yidan, additional, Pan, Dongxia, additional, Huang, Yuelong, additional, Chen, Biyun, additional, Yin, Li, additional, Jin, Donghui, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Qiaohua, additional, Xu, Xin, additional, Zhang, Hao, additional, Xiong, Youping, additional, Long, Huajun, additional, Li, Xianzhi, additional, Zhang, Libo, additional, and Qiu, Zhe, additional

Published
2018
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19. Smoking and smoking cessation in relation to risk of diabetes in Chinese men and women: a 9-year prospective study of 0·5 million people

Author

Liu, Xin, primary, Bragg, Fiona, additional, Yang, Ling, additional, Kartsonaki, Christiana, additional, Guo, Yu, additional, Du, Huaidong, additional, Bian, Zheng, additional, Chen, Yiping, additional, Yu, Canqing, additional, Lv, Jun, additional, Wang, Kang, additional, Zhang, Hua, additional, Chen, Junshi, additional, Clarke, Robert, additional, Collins, Rory, additional, Peto, Richard, additional, Li, Liming, additional, Chen, Zhengming, additional, Walters, Robin, additional, Avery, Daniel, additional, Bennett, Derrick, additional, Boxall, Ruth, additional, Chang, Yumei, additional, Gilbert, Simon, additional, Hacker, Alex, additional, Holmes, Michael, additional, Kerosi, Rene, additional, Lancaster, Garry, additional, Lin, Kuang, additional, McDonnell, John, additional, Millwood, Iona, additional, Nie, Qunhua, additional, Radhakrishnan, Jayakrishnan, additional, Ryder, Paul, additional, Sansome, Sam, additional, Schmidt, Dan, additional, Sohoni, Rajani, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Wang, Jenny, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Xiaoming, additional, Chen, Ge, additional, Han, Xiao, additional, Hou, Can, additional, Pei, Pei, additional, Qu, Shuzhen, additional, Tan, Yunlong, additional, Pang, Zengchang, additional, Gao, Ruqin, additional, Wang, Shaojie, additional, Liu, Yongmei, additional, Du, Ranran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Yin, Jiyuan, additional, Jiang, Ge, additional, Zhou, Xue, additional, Yang, Liqiu, additional, He, Hui, additional, Yu, Bo, additional, Li, Yanjie, additional, Mu, Huaiyi, additional, Xu, Qinai, additional, Dou, Meiling, additional, Ren, Jiaojiao, additional, Wang, Shanqing, additional, Hu, Ximin, additional, Wang, Hongmei, additional, Chen, Jinyan, additional, Fu, Yan, additional, Fu, Zhenwang, additional, Wang, Xiaohuan, additional, Weng, Min, additional, Zheng, Xiangyang, additional, Li, Yilei, additional, Li, Huimei, additional, Wang, Yanjun, additional, Wu, Ming, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Ni, Chuanming, additional, Zhang, Jun, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Tang, Zhenzhu, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Jiang, Qilian, additional, Zhang, Weiyuan, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Chen, Ningyu, additional, Guan, Hairong, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Tang, Xuefeng, additional, Luo, Guojin, additional, Li, Jianguo, additional, Zhong, Xunfu, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Xiaoping, additional, Wang, Tao, additional, Zhang, Xi, additional, Zhang, Ding, additional, Zhou, Gang, additional, Feng, Shixian, additional, Chang, Liang, additional, Fan, Lei, additional, Gao, Yulian, additional, He, Tianyou, additional, Sun, Huarong, additional, He, Pan, additional, Hu, Chen, additional, Lv, Qiannan, additional, Zhang, Xukui, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Qian, Yijian, additional, Wang, Chunmei, additional, Xie, Kaixue, additional, Chen, Lingli, additional, Zhang, Yidan, additional, Pan, Dongxia, additional, Huang, Yuelong, additional, Chen, Biyun, additional, Yin, Li, additional, Jin, Donghui, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Qiaohua, additional, Xu, Xin, additional, Zhang, Hao, additional, Xiong, Youping, additional, Long, Huajun, additional, Li, Xianzhi, additional, Zhang, Libo, additional, and Qiu, Zhe, additional

Published
2018
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20. Self‐Rated Health Status and Risk of Ischemic Heart Disease in the China Kadoorie Biobank Study: A Population‐Based Cohort Study

Author

Dong, Wenhong, primary, Pan, Xiong‐Fei, additional, Yu, Canqing, additional, Lv, Jun, additional, Guo, Yu, additional, Bian, Zheng, additional, Yang, Ling, additional, Chen, Yiping, additional, Wu, Tangchun, additional, Chen, Zhengming, additional, Pan, An, additional, Li, Liming, additional, Chen, Junshi, additional, Collins, Rory, additional, Peto, Richard, additional, Avery, Daniel, additional, Boxall, Ruth, additional, Derrick, Bennett, additional, Chang, Yumei, additional, Clarke, Robert, additional, Du, Huaidong, additional, Gilbert, Simon, additional, Hacker, Alex, additional, Hill, Mike, additional, Holmes, Michael, additional, Iona, Andri, additional, Kartsonaki, Christiana, additional, Kerosi, Rene, additional, Kong, Ling, additional, Kurmi, Om, additional, Lancaster, Garry, additional, Lewington, Sarah, additional, Lin, Kuang, additional, McDonnell, John, additional, Millwood, Iona, additional, Nie, Qunhua, additional, Radhakrishnan, Jayakrishnan, additional, Rafiq, Sajjad, additional, Ryder, Paul, additional, Sansome, Sam, additional, Schmidt, Dan, additional, Sherliker, Paul, additional, Sohoni, Rajani, additional, Stevens, Becky, additional, Turnbull, Iain, additional, Walters, Robin, additional, Wang, Jenny, additional, Wang, Lin, additional, Wright, Neil, additional, Yang, Xiaoming, additional, Han, Xiao, additional, Hou, Can, additional, Pei, Pei, additional, Tan, Yunlong, additional, Pang, Zengchang, additional, Gao, Ruqin, additional, Li, Shanpeng, additional, Wang, Shaojie, additional, Liu, Yongmei, additional, Du, Ranran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Zhang, Hua, additional, Zhai, Yaoming, additional, Ning, Feng, additional, Sun, Xiaohui, additional, Li, Feifei, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Zeng, Mingyuan, additional, Jiang, Ge, additional, Zhou, Xue, additional, Yang, Liqiu, additional, He, Hui, additional, Yu, Bo, additional, Li, Yanjie, additional, Xu, Qinai, additional, Kang, Quan, additional, Guo, Ziyan, additional, Wang, Dan, additional, Hu, Ximin, additional, Wang, Hongmei, additional, Chen, Jinyan, additional, Fu, Yan, additional, Fu, Zhenwang, additional, Wang, Xiaohuan, additional, Weng, Min, additional, Guo, Zhendong, additional, Wu, Shukuan, additional, Li, Yilei, additional, Li, Huimei, additional, Fu, Zhifang, additional, Wu, Ming, additional, Zhou, Yonglin, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Su, Jian, additional, liu, Fang, additional, Zhang, Jun, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Tang, Zhenzhu, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Jiang, Qilian, additional, Lan, Jian, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Chen, Ningyu, additional, Wang, Ping, additional, Meng, Fanwen, additional, Qin, Yulu, additional, Wang, Sisi, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Zhou, Weiwei, additional, Luo, Guojin, additional, Li, Jianguo, additional, Zhong, Xunfu, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Xiaoping, additional, Wang, Tao, additional, zhang, Xi, additional, Zhang, Ding, additional, Zhou, Gang, additional, Feng, Shixian, additional, Chang, Liang, additional, Fan, Lei, additional, Gao, Yulian, additional, He, Tianyou, additional, Sun, Huarong, additional, He, Pan, additional, Hu, Chen, additional, Zhang, Xukui, additional, Wu, Huifang, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Qian, Yijian, additional, Wang, Chunmei, additional, Xie, Kaixu, additional, Chen, Lingli, additional, Zhang, Yidan, additional, Pan, Dongxia, additional, Gu, Qijun, additional, Huang, Yuelong, additional, Chen, Biyun, additional, Yin, Li, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Qiaohua, additional, Xu, Xin, additional, Zhang, Hao, additional, Long, Huajun, additional, Li, Xianzhi, additional, Zhang, Libo, additional, and Qiu, Zhe, additional

Published
2017
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21. Adherence to Healthy Lifestyle and Cardiovascular Diseases in the Chinese Population

Author

Lv, Jun, primary, Yu, Canqing, additional, Guo, Yu, additional, Bian, Zheng, additional, Yang, Ling, additional, Chen, Yiping, additional, Tang, Xuefeng, additional, Zhang, Weiyuan, additional, Qian, Yijian, additional, Huang, Yuelong, additional, Wang, Xiaoping, additional, Chen, Junshi, additional, Chen, Zhengming, additional, Qi, Lu, additional, Li, Liming, additional, Collins, Rory, additional, Peto, Richard, additional, Avery, Daniel, additional, Boxall, Ruth, additional, Bennett, Derrick, additional, Chang, Yumei, additional, Clarke, Robert, additional, Du, Huaidong, additional, Gilbert, Simon, additional, Hacker, Alex, additional, Holmes, Michael, additional, Iona, Andri, additional, Kartsonaki, Christiana, additional, Kerosi, Rene, additional, Kong, Ling, additional, Kurmi, Om, additional, Lancaster, Garry, additional, Lewington, Sarah, additional, Lin, Kuang, additional, McDonnell, John, additional, Mei, Winnie, additional, Millwood, Iona, additional, Nie, Qunhua, additional, Radhakrishnan, Jayakrishnan, additional, Rafiq, Sajjad, additional, Ryder, Paul, additional, Sansome, Sam, additional, Schmidt, Dan, additional, Sherliker, Paul, additional, Sohoni, Rajani, additional, Turnbull, Iain, additional, Walters, Robin, additional, Wang, Jenny, additional, Wang, Lin, additional, Yang, Xiaoming, additional, Chen, Ge, additional, Han, Bingyang, additional, Hou, Can, additional, Lv, Jun, additional, Pei, Pei, additional, Qu, Shuzhen, additional, Tan, Yunlong, additional, Yu, Caning, additional, Zhou, Haiyan, additional, Pang, Zeng hang, additional, Gao, Ruin, additional, Wang, Shoji, additional, Liu, Yong-Mei, additional, Du, Ran ran, additional, Zang, Yajing, additional, Cheng, Liang, additional, Tian, Xiaocao, additional, Zhang, Hua, additional, Lv, Silu, additional, Wang, Junzheng, additional, Hou, Wei, additional, Yin, Jiyuan, additional, Jiang, Ge, additional, Zhou, Xue, additional, Yang, Liqiu, additional, He, Hui, additional, Yu, Bo, additional, Li, Yanjie, additional, Mu, Huaiyi, additional, Xu, Qinai, additional, Dou, Meiling, additional, Ren, Jiaojiao, additional, Wang, Shanqing, additional, Hu, Ximin, additional, Wang, Hongmei, additional, Chen, Jinyan, additional, Fu, Yan, additional, Fu, Zhenwang, additional, Wang, Xiaohuan, additional, Weng, Min, additional, Zheng, Xiangyang, additional, Li, Yilei, additional, Li, Huimei, additional, Wang, Yanjun, additional, Wu, Ming, additional, Zhou, Jinyi, additional, Tao, Ran, additional, Yang, Jie, additional, Ni, Chuanming, additional, Zhang, Jun, additional, Hu, Yihe, additional, Lu, Yan, additional, Ma, Liangcai, additional, Tang, Aiyu, additional, Zhang, Shuo, additional, Jin, Jianrong, additional, Liu, Jingchao, additional, Tang, Zhenzhu, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Pan, Rong, additional, Jiang, Qilian, additional, Liu, Yun, additional, Wei, Liuping, additional, Zhou, Liyuan, additional, Chen, Ningyu, additional, Guan, Hairong, additional, Wu, Xianping, additional, Zhang, Ningmei, additional, Chen, Xiaofang, additional, Luo, Guojin, additional, Li, Jianguo, additional, Zhong, Xunfu, additional, Liu, Jiaqiu, additional, Sun, Qiang, additional, Ge, Pengfei, additional, Ren, Xiaolan, additional, Dong, Caixia, additional, Zhang, Hui, additional, Mao, Enke, additional, Wang, Tao, additional, zhang, Xi, additional, Zhang, Ding, additional, Zhou, Gang, additional, Feng, Shixian, additional, Chang, Liang, additional, Fan, Lei, additional, Gao, Yulian, additional, He, Tianyou, additional, Sun, Huarong, additional, He, Pan, additional, Hu, Chen, additional, Lv, Qiannan, additional, Zhang, Xukui, additional, Yu, Min, additional, Hu, Ruying, additional, Wang, Hao, additional, Wang, Chunmei, additional, Xie, Kaixue, additional, Chen, Lingli, additional, Zhang, Yidan, additional, Pan, Dongxia, additional, Chen, Biyun, additional, Yin, Li, additional, Jin, Donghui, additional, Liu, Huilin, additional, Fu, Zhongxi, additional, Xu, Qiaohua, additional, Xu, Xin, additional, Zhang, Hao, additional, Xiong, Youping, additional, Long, Huajun, additional, Li, Xianzhi, additional, Zhang, Libo, additional, and Qiu, Zhe, additional

Published
2017
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22. Association of Major Depression With Risk of Ischemic Heart Disease in a Mega‐Cohort of Chinese Adults: The China Kadoorie Biobank Study

Author

Liu, Na, primary, Pan, Xiong‐Fei, additional, Yu, Canqing, additional, Lv, Jun, additional, Guo, Yu, additional, Bian, Zheng, additional, Yang, Ling, additional, Chen, Yiping, additional, Wu, Tangchun, additional, Chen, Zhengming, additional, Pan, An, additional, Li, Liming, additional, Chen, Junshi, additional, Collins, Rory, additional, Peto, Richard, additional, Lancaster, Garry, additional, Yang, Xiaoming, additional, Williams, Alex, additional, Smith, Margaret, additional, Chang, Yumei, additional, Zhao, Guoqing, additional, Wu, Lixue, additional, Hou, Can, additional, Pang, Zengchang, additional, Wang, Shaojie, additional, Zhang, Yun, additional, Zhang, Kui, additional, Liu, Silu, additional, Zhao, Zhonghou, additional, Liu, Shumei, additional, Pang, Zhigang, additional, Feng, Weijia, additional, Wu, Shuling, additional, Yang, Liqiu, additional, Han, Huili, additional, He, Hui, additional, Pan, Xianhai, additional, Wang, Shanqing, additional, Wang, Hongmei, additional, Hao, Xinhua, additional, Chen, Chunxing, additional, Lin, Shuxiong, additional, Hu, Xiaoshu, additional, Zhou, Minghao, additional, Wu, Ming, additional, Wang, Yeyuan, additional, Hu, Yihe, additional, Ma, Liangcai, additional, Zhou, Renxian, additional, Xu, Guanqun, additional, Dong, Baiqing, additional, Chen, Naying, additional, Huang, Ying, additional, Li, Mingqiang, additional, Meng, Jinhuai, additional, Gan, Zhigao, additional, Xu, Jiujiu, additional, Liu, Yun, additional, Wu, Xianping, additional, Gao, Yali, additional, Zhang, Ningmei, additional, Luo, Guojin, additional, Que, Xiangsan, additional, Chen, Xiaofang, additional, Ge, Pengfei, additional, He, Jian, additional, Ren, Xiaolan, additional, Zhang, Hui, additional, Mao, Enke, additional, Li, Guanzhong, additional, Li, Zhongxiao, additional, He, Jun, additional, Liu, Guohua, additional, Zhu, Baoyu, additional, Zhou, Gang, additional, Feng, Shixian, additional, Gao, Yulian, additional, He, Tianyou, additional, Jiang, Li, additional, Qin, Jianhua, additional, Sun, Huarong, additional, Liu, Liqun, additional, Yu, Min, additional, Chen, Yaping, additional, Hu, Zhixiang, additional, Hu, Jianjin, additional, Qian, Yijian, additional, Wu, Zhiying, additional, Chen, Lingli, additional, Liu, Wen, additional, Li, Guangchun, additional, Liu, Huilin, additional, Long, Xiangquan, additional, Xiong, Youping, additional, Tan, Zhongwen, additional, Xie, Xuqiu, additional, and Peng, Yunfang, additional

Published
2016
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23. The Genetic Architecture of Depression in Individuals of East Asian Ancestry

Author

Giannakopoulou, Olga, Lin, Kuang, Meng, Xiangrui, Su, Mei-Hsin, Kuo, Po-Hsiu, Peterson, Roseann E., Awasthi, Swapnil, Moscati, Arden, Coleman, Jonathan R. I., Bass, Nick, Millwood, Iona Y., Chen, Yiping, Chen, Zhengming, Chen, Hsi-Chung, Lu, Mong-Liang, Huang, Ming-Chyi, Chen, Chun-Hsin, Stahl, Eli A., Loos, Ruth J. F., Mullins, Niamh, Ursano, Robert J., Kessler, Ronald C., Stein, Murray B., Sen, Srijan, Scott, Laura J., Burmeister, Margit, Fang, Yu, Tyrrell, Jess, Jiang, Yunxuan, Tian, Chao, McIntosh, Andrew M., Ripke, Stephan, Dunn, Erin C., Kendler, Kenneth S., Walters, Robin G., Lewis, Cathryn M., Kuchenbaecker, Karoline, Wray, Naomi R., Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Colodro-Conde, Lucía, Coon, Hilary, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Derks, Eske M., Direk, Nese, Dolan, Conor V., Eley, Thalia C., Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K., Foo, Jerome C., Forstner, Andreas J., Frank, Josef, Gaspar, Héléna A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Grove, Jakob, Hall, Lynsey S., Hansen, Christine Søholm, Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Howard, David M., Hougaard, David M., Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A., Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Kutalik, Zoltán, Li, Yihan, Lind, Penelope A., Luykx, Jurjen J., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., O'Reilly, Paul F., Oskarsson, Hogni, Owen, Michael J., Painter, Jodie N., Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pettersson, Erik, Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shi, Jianxin, Shyn, Stanley I., Sigurdsson, Engilbert, Sinnamon, Grant C. B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thompson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, André G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T, Berger, Klaus, Boomsma, Dorret I., Cichon, Sven, Dannlowski, Udo, de Geus, EJC, DePaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Grabe, Hans J., Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela AF, Magnusson, Patrik K., Martin, Nicholas G., Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Penninx, Brenda WJH, Perlis, Roy H., Porteous, David J., Potash, James B., Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M., Werge, Thomas, Levinson, Douglas F., Breen, Gerome, Børglum, Anders D., Sullivan, Patrick F., Agee, Michelle, Aslibekyan, Stella, Auton, Adam, Babalola, Elizabeth, Bell, Robert K., Bielenberg, Jessica, Bryc, Katarzyna, Bullis, Emily, Cameron, Briana, Coker, Daniella, Cuellar Partida, Gabriel, Dhamija, Devika, Das, Sayantan, Elson, Sarah L., Filshtein, Teresa, Fletez-Brant, Kipper, Fontanillas, Pierre, Freyman, Will, Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Kleinman, Aaron, Kukar, Katelyn, Lane, Vanessa, Lin, Keng-Han, Lowe, Maya, Luff, Marie K., McCreight, Jennifer C., McIntyre, Matthew H., McManus, Kimberly F., Micheletti, Steven J., Moreno, Meghan E., Mountain, Joanna L., Mozaffari, Sahar V., Nandakumar, Priyanka, Noblin, Elizabeth S., O'Connell, Jared, Petrakovitz, Aaron A., Poznik, G. 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24. Regional variations in the prevalence and misdiagnosis of air flow obstruction in China: baseline results from a prospective cohort of the China Kadoorie Biobank (CKB).

Author

Kurmi OP, Li L, Smith M, Augustyn M, Chen J, Collins R, Guo Y, Han Y, Qin J, Xu G, Wang J, Bian Z, Zhou G, Davis K, Peto R, Chen Z, Li L, Chen Z, Chen J, Collins R, Peto R, Chen Z, Lancaster G, Yang X, Williams A, Smith M, Yang L, Chang Y, Millwood I, Chen Y, Lewington S, Sansome S, Walters R, Kurmi O, Guo Y, Bian Z, Hou C, Tan Y, Wang Z, Cai X, Zhou H, Chen X, Pang Z, Li S, Wang S, Lv S, Zhao Z, Liu S, Pang Z, Yang L, He H, Yu B, Wang S, Wang H, Chen C, Zheng X, Hu X, Zhou M, Wu M, Tao R, Wang Y, Hu Y, Ma L, Zhou R, Tang Z, Chen N, Huang Y, Li M, Gan Z, Meng J, Qin J, Wu X, Zhang N, Luo G, Que X, Chen X, Ge P, Ren X, Dong C, Zhang H, Mao E, Li Z, Zhou G, Feng S, Gao Y, He T, Jiang L, Sun H, Yu M, Su D, Lu F, Qian Y, Shi K, Han Y, Chen L, Li G, Liu H, Yin L, Xiong Y, Tan Z, and Jia W

Abstract

Background: Despite the great burden of chronic respiratory diseases in China, few large multicentre, spirometry-based studies have examined its prevalence, rate of underdiagnosis regionally or the relevance of socioeconomic and lifestyle factors., Methods: We analysed data from 512 891 adults in the China Kadoorie Biobank, recruited from 10 diverse regions of China during 2004-2008. Air flow obstruction (AFO) was defined by the lower limit of normal criteria based on spirometry-measured lung function. The prevalence of AFO was analysed by region, age, socioeconomic status, body mass index (BMI) and smoking history and compared with the prevalence of self-reported physician-diagnosed chronic bronchitis or emphysema (CB/E) and its symptoms., Findings: The prevalence of AFO was 7.3% in men (range 2.5-18.2%) and 6.4% in women (1.5-18.5%). Higher prevalence of AFO was associated with older age (p<0.0001), lower income (p<0.0001), poor education (p<0.001), living in rural regions (p<0.001), those who started smoking before the age of 20 years (p<0.001) and low BMI (p<0.001). Compared with self-reported diagnosis of CB/E, 88.8% of AFO was underdiagnosed; underdiagnosis proportion was highest in 30-39-year olds (96.7%) compared with the 70+ age group (81.1%), in women (90.7%), in urban areas (89.4%), in people earning 5K-10 K ¥ monthly (90.3%) and in those with middle or high school education (92.6%)., Interpretation: In China, the burden of AFO based on spirometry was high and significantly greater than that estimated based on self-reported physician-diagnosed CB/E, especially in rural areas, reflecting major issues with diagnosis of AFO that will impact disease treatment and management.

Published
2014
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