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1. Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study

Author

Callejas, José Luis, Caminal-Montero, Luis, Corbera-Bellalta, Marc, de Miguel, Eugenio, Díaz-López, J. Bernardino, García-Villanueva, María Jesús, Gómez-Vaquero, Carmen, Guijarro-Rojas, Mercedes, Hidalgo-Conde, Ana, Marí-Alfonso, Begoña, Martínez-Berriochoa, Agustín, Morado, Inmaculada C., Narváez, Javier, Ramentol-Sintas, Marc, Martínez-Zapico, Aleida, Martínez-Taboada, Víctor Manuel, Miranda-Filloy, José A., Monfort, Jordi, Pérez-Conesa, Mercedes, Prieto-González, Sergio, Raya, Enrique, Ríos-Fenández, Raquel, Sánchez-Martín, Julio, Sopeña, Bernardo, Tío, Laura, Unzurrunzaga, Ainhoa, Wordsworth, Oliver, Whitwell, Isobel, Brock, Jessica, Douglas, Victoria, Hettiarachchi, Chamila, Bartholomew, Jacqui, Jarrett, Stephen, Smithson, Gayle, Green, Michael, Brown, Pearl Clark, Lawson, Cathy, Gordon, Esther, Lane, Suzanne, Francis, Rebecca, Dasgupta, Bhaskar, Masunda, Bridgett, Calver, Jo, Patel, Yusuf, Thompson, Charlotte, Gregory, Louise, Levy, Sarah, Menon, Ajit, Thompson, Amy, Dyche, Lisa, Martin, Michael, Li, Charles, Laxminarayan, Ramasharan, Wilcox, Louise, de Guzman, Ralph, Isaacs, John, Lorenzi, Alice, Farley, Ross, Hinchcliffe-Hume, Helain, Bejarano, Victoria, Hope, Susan, Nandi, Pradip, Stockham, Lynne, Wilde, Catherine, Durrant, Donna, Lloyd, Mark, Ye, Chee-Seng, Stevens, Rob, Jilani, Amjad, Collins, David, Pegler, Suzannah, Rivett, Ali, Price, Liz, McHugh, Neil, Skeoch, Sarah, O'Kane, Diana, Kirkwood, Sue, Vadivelu, Saravanan, Pugmire, Susan, Sultan, Shabina, Dooks, Emma, Armstrong, Lisa, Sadik, Hala, Nandagudi, Anupama, Abioye, Tolu, Ramos, Angelo, Gumus, Steph, Sofat, Nidhi, Harrison, Abiola, Seward, Abi, Mollan, Susan, Rahan, Ray, Hawkins, Helen, Emsley, Hedley, Bhargava, Anna, Fleming, Vicki, Hare, Marianne, Raj, Sonia, George, Emmanuel, Allen, Nicola, Hunter, Karl, O'Sullivan, Eoin, Bird, Georgina, Magliano, Malgorzata, Manzo, Katarina, Sanghera, Bobbie, Hutchinson, David, Hammonds, Fiona, Sharma, Poonam, Cooper, Richard, McLintock, Graeme, Al-Saffar, Zaid S., Green, Mike, Elliott, Kerry, Neale, Tania, Mallinson, Janine, Lanyon, Peter, Pradere, Marie-Josephe, Jordan, Natasha, Htut, Ei Phyu, Mushapaidzi, Thelma, Abercrombie, Donna, Wright, Sam, Rowlands, Jane, Mukhtyar, Chetan, Kennedy, James, Makkuni, Damodar, Wilhelmsen, Elva, Kouroupis, Michael, John, Lily, Hughes, Rod, Walsh, Margaret, Buckley, Marie, Mackay, Kirsten, Camden-Woodley, Tracey, Redome, Joan, Pearce, Kirsty, Marianayagam, Thiraupathy, Cruz, Carina, Warner, Elizabeth, Atchia, Ishmael, Walker, Claire, Black, Karen, Duffy, Stacey, Fothergill, Lynda, Jefferey, Rebecca, Toomey, Jackie, Rhys-Dillon, Ceril, Pothecary, Carla, Green, Lauren, Toms, Tracey, Maher, Linda, Davis, Diana, Sayan, Amrinder, Thankachen, Mini, Abusalameh, Mahdi, Record, Jessica, Khan, Asad, Stafford, Sam, Hussein, Azza, Williams, Clare, Fletcher, Alison, Johson, Laura, Burnett, Richard, Moots, Robert, Frankland, Helen, Dale, James, Moar, Kirsten, Hollas, Carol, Parker, Ben, Ridings, Derek, Eapen, Sandhya, John, Sindhu, Robson, Jo, Guthrie, Lucy Belle, Fyfe, Rose, Tait, Moira, Marks, Jonathan, Gunter, Emma, Hernandez, Rochelle, Bhat, Smita, Johnston, Paul, Khurshid, Muhammad, Barclay, Charlotte, Kapur, Deepti, Jeffrey, Helen, Hughes, Anna, Slack, Lauren, Thomas, Eleri, Royon, Anna, Hall, Angela, King, Jon, Nyathi, Sindi, Morris, Vanessa, Castelino, Madhura, Hawkins, Ellie, Tomson, Linda, Singh, Animesh, Nunag, Annalyn, O'Connor, Stella, Rushby, Nathan, Hewitson, Nicola, O'Sunmboye, Kenny, Lewszuk, Adam, Boyles, Louise, Perry, Martin, Williams, Emma, Graver, Christine, Defever, Emmanuel, Kamanth, Sanjeet, Kay, Dominic, Ogor, Joe, Winter, Louise, Horton, Sarah, Welch, Gillian, Hollinshead, Kath, Peters, James, Labao, Julius, Dmello, Andrea, Dawson, Julie, Graham, Denise, De Lord, Denise, Deery, Jo, Hazelton, Tracy, Carette, Simon, Chung, Sharon, Cuthbertson, David, Forbess, Lindsy J., Gewurz-Singer, Ora, Hoffman, Gary S., Koening, Curry L., Maksimowicz-McKinnon, Kathleen M., McAlear, Carol A., Moreland, Larry W., Pagnoux, Christian, Seo, Philip, Specks, Ulrich, Spiera, Robert F., Sreih, Antoine, Warrington, Kenneth J., Monach, Paul A., Weisman, Michael, Borrego-Yaniz, Gonzalo, Ortiz-Fernández, Lourdes, Madrid-Paredes, Adela, Kerick, Martin, Hernández-Rodríguez, José, Mackie, Sarah L, Vaglio, Augusto, Castañeda, Santos, Solans, Roser, Mestre-Torres, Jaume, Khalidi, Nader, Langford, Carol A, Ytterberg, Steven, Beretta, Lorenzo, Govoni, Marcello, Emmi, Giacomo, Cimmino, Marco A, Witte, Torsten, Neumann, Thomas, Holle, Julia, Schönau, Verena, Pugnet, Gregory, Papo, Thomas, Haroche, Julien, Mahr, Alfred, Mouthon, Luc, Molberg, Øyvind, Diamantopoulos, Andreas P, Voskuyl, Alexandre, Daikeler, Thomas, Berger, Christoph T, Molloy, Eamonn S, Blockmans, Daniel, van Sleen, Yannick, Iles, Mark, Sorensen, Louise, Luqmani, Raashid, Reynolds, Gary, Bukhari, Marwan, Bhagat, Shweta, Ortego-Centeno, Norberto, Brouwer, Elisabeth, Lamprecht, Peter, Klapa, Sebastian, Salvarani, Carlo, Merkel, Peter A, Cid, María C, González-Gay, Miguel A, Morgan, Ann W, Martin, Javier, and Márquez, Ana

Published
2024
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4. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Au Peh, Chen, Chakera, Aron, Cooper, Bruce, Kurtkoti, Jagadeesh, Langguth, Daman, Levidiotis, Vicki, Luxton, Grant, Mount, Peter, Mudge, David, Noble, Euan, Phoon, Richard, Ranganathan, Dwarakanathan, Ritchie, Angus, Ryan, Jessica, Suranyi, Michael, Rosenkranz, Alexander, Lhotta, Karl, Kronbichler, Andreas, Demoulin, Nathalie, Bovy, Christophe, Hellemans, Rachel, Hougardy, Jean-Michel, Sprangers, Ben, Wissing, Karl Martin, Pagnoux, Christian, Barbour, Sean, Brachemi, Soumeya, Cournoyer, Serge, Girard, Louis-Philippe, Laurin, Louis-Philippe, Liang, Patrick, Philibert, David, Walsh, Michael, Tesar, Vladimir, Becvar, Radim, Horak, Pavel, Rychlik, Ivan, Szpirt, Wladimir, Dieperink, Hans, Gregersen, Jon Waarst, Ivarsen, Per, Krarup, Elizabeth, Lyngsoe, Cecilie, Rigothier, Claire, Augusto, Jean-Francois, Belot, Alexandre, Chauveau, Dominique, Cornec, Divi, Jourde-Chiche, Noemie, Ficheux, Maxence, Karras, Alexandre, Klein, Alexandre, Maurier, Francois, Mesbah, Rafik, Moranne, Olivier, Neel, Antoine, Quemeneur, Thomas, Saadoun, David, Terrier, Benjamin, Zaoui, Philippe, Schaier, Matthias, Benck, Urs Tobias, Bergner, Raoul, Busch, Martin, Floege, Juergen, Grundmann, Franziska, Haller, Hermann, Haubitz, Marion, Hellmich, Bernhard, Henes, Joerg Christoph, Hohenstein, Bernd, Hugo, Christian, Iking-Konert, Christof, Arndt, Fabian, Kubacki, T, Kotter, Ina, Lamprecht, Peter, Lindner, Tom, Halbritter, Jan, Mehling, Heidrun, Schönermarck, Ulf, Venhoff, Nils, Vielhauer, Volker, Witzke, Oliver, Szombati, Istvan, Szucs, Gabriella, Garibotto, Giacomo, Alberici, Federico, Brunetta, Enrico, Dagna, Lorenzo, De Vita, Salvatore, Emmi, Giacomo, Gabrielli, Armando, Manenti, Lucio, Pieruzzi, Federico, Roccatello, Dario, Salvarani, Carlo, Harigai, Masayoshi, Dobashi, Hiroaki, Atsumi, Tatsuya, Fujimoto, Shoichi, Hagino, Noboru, Ihata, Atsushi, Kaname, Shinya, Kaneko, Yuko, Katagiri, Akira, Katayama, Masao, Kirino, Yohei, Kitagawa, Kiyoki, Komatsuda, Atsushi, Kono, Hajime, Kurasawa, Takahiko, Matsumura, Ryutaro, Mimura, Toshihide, Morinobu, Akio, Murakawa, Yohko, Naniwa, Taio, Nanki, Toshihiro, Ogawa, Noriyoshi, Oshima, Hisaji, Sada, Kenei, Sugiyama, Eiji, Takeuchi, Tohru, Taki, Hirofumi, Tamura, Naoto, Tsukamoto, Tatsuo, Yamagata, Kunihiro, Yamamura, Masahiro, van Daele, Paulus Leon Arthur, Rutgers, Abraham, Teng, Y.K. Onno, Walker, Robert, Chua, Ignatius, Collins, Michael, Rabindranath, Kannaiyan, de Zoysa, Janak, Svensson, My Hanna Sofia, Grevbo, Bard-Waldum, Kalstad, Synove, Little, Mark, Clarkson, Michael, Molloy, Eamonn, Agraz Pamplona, Irene, Anton, Jordi, Barrio Lucia, Vicente, Ciggaran, Secundino, Cinta Cid, Maria, Diaz Encarnacion, Montserrat, Fulladosa Oliveras, Xavier, Jose Soler, Maria, Marco Rusinol, Helena, Praga, Manuel, Quintana Porras, Luis, Segarra, Alfons, Bruchfeld, Annette, Segelmark, Marten, Soveri, Inga, Thomaidi, Eleni, Westman, Kerstin, Neumann, Thomas, Burnier, Michel, Daikeler, Thomas, Dudler, Jean, Hauser, Thomas, Seeger, Harald, Vogt, Bruno, Burton, James, Al Jayyousi, Reem, Amin, Tania, Andrews, Jacqueline, Baines, Laura Anne, Brogan, Paul, Dasgupta, Bhaskar, Doulton, Timothy William Ronald, Flossmann, Oliver, Griffin, Sian V., Harper, Janice Marian, Harper, Lorraine, Kidder, Dana, Klocke, Rainer, Lanyon, Peter Charles, Luqmani, Raashid, McLaren, John Stuart, Makanjuola, David Osagie, McCann, Liza, Nandagudi, Anupama C., Selvan, Shilpa, O'Riordan, Edmond, Patel, Mumtaz, Patel, Rajan Kantilal, Pusey, Charles Dickson, Rajakariar, Ravindra, Robson, Joanna C., Robson, Michael, Salama, Alan David, Smyth, Lucy, Sznajd, Jan, Taylor, Joanne, Sreih, Antonie G., Belilos, Elise, Bomback, Andrew S., Carlin, Jeffrey, Chang Chen Lin, Yih, Derebail, Vimal K., Dragoi, Serban, Dua, Anisha, Forbess, Lindsy, Geetha, Duvuru, Gipson, Patrick, Gohh, Reginald, Greenwood, Gregory Todd, Hugenberg, Steven T., Jimenez, Richard A.H., Kaskas, Marwan Omar, Kermani, Tanaz, Kivitz, Alan J., Koening, Curry, Langford, Carol A., Marder, Galina, Mohamed, Amr Ahmed El-Huesseini, Monach, Paul, Neyra, Nilda Roxana, Niemer, Gregory W., Niles, John, Obi, Reginald, Owens, Charles, Parks, Deborah L., Podoll, Amber S., Rovin, Brad, Sam, R, Shergy, William Julius, Silva, Arnold Lawrence, Specks, Ulrich, Spiera, Robert, Springer, Jason M., Striebich, Christopher Charles, Swarup, Areena, Thakar, Surabhi, Tiliakos, Athan N., Tsai, Yong, Waguespack, Dia R., Chester Wasko, Mary, Strand, Vibeke, Jayne, David R W, Horomanski, Audra, Yue, Huibin, Bekker, Pirow, and Merkel, Peter A

Published
2023
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5. Safety and efficacy of secukinumab in patients with giant cell arteritis (TitAIN): a randomised, double-blind, placebo-controlled, phase 2 trial

Author

Venhoff, Nils, Schmidt, Wolfgang A, Bergner, Raoul, Rech, Jürgen, Unger, Leonore, Tony, Hans-Peter, Finzel, Stephanie, Andreica, Ioana, Kofler, David M, Weiner, Stefan M, Lamprecht, Peter, Schulze-Koops, Hendrik, App, Christine, Pournara, Effie, Mendelson, Meryl H, Sieder, Christian, Maricos, Meron, and Thiel, Jens

Published
2023
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6. Autoimmune pre-disease

Author

Bieber, Katja, Hundt, Jennifer E., Yu, Xinhua, Ehlers, Marc, Petersen, Frank, Karsten, Christian M., Köhl, Jörg, Kridin, Khalaf, Kalies, Kathrin, Kasprick, Anika, Goletz, Stephanie, Humrich, Jens Y., Manz, Rudolf A., Künstner, Axel, Hammers, Christoph M., Akbarzadeh, Reza, Busch, Hauke, Sadik, Christian D., Lange, Tanja, Grasshoff, Hanna, Hackel, Alexander M., Erdmann, Jeanette, König, Inke, Raasch, Walter, Becker, Mareike, Kerstein-Stähle, Anja, Lamprecht, Peter, Riemekasten, Gabriela, Schmidt, Enno, and Ludwig, Ralf J.

Published
2023
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8. Risk loci involved in giant cell arteritis susceptibility: a genome-wide association study

Author

Borrego-Yaniz, Gonzalo, primary, Ortiz-Fernández, Lourdes, additional, Madrid-Paredes, Adela, additional, Kerick, Martin, additional, Hernández-Rodríguez, José, additional, Mackie, Sarah L, additional, Vaglio, Augusto, additional, Castañeda, Santos, additional, Solans, Roser, additional, Mestre-Torres, Jaume, additional, Khalidi, Nader, additional, Langford, Carol A, additional, Ytterberg, Steven, additional, Beretta, Lorenzo, additional, Govoni, Marcello, additional, Emmi, Giacomo, additional, Cimmino, Marco A, additional, Witte, Torsten, additional, Neumann, Thomas, additional, Holle, Julia, additional, Schönau, Verena, additional, Pugnet, Gregory, additional, Papo, Thomas, additional, Haroche, Julien, additional, Mahr, Alfred, additional, Mouthon, Luc, additional, Molberg, Øyvind, additional, Diamantopoulos, Andreas P, additional, Voskuyl, Alexandre, additional, Daikeler, Thomas, additional, Berger, Christoph T, additional, Molloy, Eamonn S, additional, Blockmans, Daniel, additional, van Sleen, Yannick, additional, Iles, Mark, additional, Sorensen, Louise, additional, Luqmani, Raashid, additional, Reynolds, Gary, additional, Bukhari, Marwan, additional, Bhagat, Shweta, additional, Ortego-Centeno, Norberto, additional, Brouwer, Elisabeth, additional, Lamprecht, Peter, additional, Klapa, Sebastian, additional, Salvarani, Carlo, additional, Merkel, Peter A, additional, Cid, María C, additional, González-Gay, Miguel A, additional, Morgan, Ann W, additional, Martin, Javier, additional, Márquez, Ana, additional, Callejas, José Luis, additional, Caminal-Montero, Luis, additional, Corbera-Bellalta, Marc, additional, de Miguel, Eugenio, additional, Díaz-López, J. Bernardino, additional, García-Villanueva, María Jesús, additional, Gómez-Vaquero, Carmen, additional, Guijarro-Rojas, Mercedes, additional, Hidalgo-Conde, Ana, additional, Marí-Alfonso, Begoña, additional, Martínez-Berriochoa, Agustín, additional, Morado, Inmaculada C., additional, Narváez, Javier, additional, Ramentol-Sintas, Marc, additional, Martínez-Zapico, Aleida, additional, Martínez-Taboada, Víctor Manuel, additional, Miranda-Filloy, José A., additional, Monfort, Jordi, additional, Pérez-Conesa, Mercedes, additional, Prieto-González, Sergio, additional, Raya, Enrique, additional, Ríos-Fenández, Raquel, additional, Sánchez-Martín, Julio, additional, Sopeña, Bernardo, additional, Tío, Laura, additional, Unzurrunzaga, Ainhoa, additional, Wordsworth, Oliver, additional, Whitwell, Isobel, additional, Brock, Jessica, additional, Douglas, Victoria, additional, Hettiarachchi, Chamila, additional, Bartholomew, Jacqui, additional, Jarrett, Stephen, additional, Smithson, Gayle, additional, Green, Michael, additional, Brown, Pearl Clark, additional, Lawson, Cathy, additional, Gordon, Esther, additional, Lane, Suzanne, additional, Francis, Rebecca, additional, Dasgupta, Bhaskar, additional, Masunda, Bridgett, additional, Calver, Jo, additional, Patel, Yusuf, additional, Thompson, Charlotte, additional, Gregory, Louise, additional, Levy, Sarah, additional, Menon, Ajit, additional, Thompson, Amy, additional, Dyche, Lisa, additional, Martin, Michael, additional, Li, Charles, additional, Laxminarayan, Ramasharan, additional, Wilcox, Louise, additional, de Guzman, Ralph, additional, Isaacs, John, additional, Lorenzi, Alice, additional, Farley, Ross, additional, Hinchcliffe-Hume, Helain, additional, Bejarano, Victoria, additional, Hope, Susan, additional, Nandi, Pradip, additional, Stockham, Lynne, additional, Wilde, Catherine, additional, Durrant, Donna, additional, Lloyd, Mark, additional, Ye, Chee-Seng, additional, Stevens, Rob, additional, Jilani, Amjad, additional, Collins, David, additional, Pegler, Suzannah, additional, Rivett, Ali, additional, Price, Liz, additional, McHugh, Neil, additional, Skeoch, Sarah, additional, O'Kane, Diana, additional, Kirkwood, Sue, additional, Vadivelu, Saravanan, additional, Pugmire, Susan, additional, Sultan, Shabina, additional, Dooks, Emma, additional, Armstrong, Lisa, additional, Sadik, Hala, additional, Nandagudi, Anupama, additional, Abioye, Tolu, additional, Ramos, Angelo, additional, Gumus, Steph, additional, Sofat, Nidhi, additional, Harrison, Abiola, additional, Seward, Abi, additional, Mollan, Susan, additional, Rahan, Ray, additional, Hawkins, Helen, additional, Emsley, Hedley, additional, Bhargava, Anna, additional, Fleming, Vicki, additional, Hare, Marianne, additional, Raj, Sonia, additional, George, Emmanuel, additional, Allen, Nicola, additional, Hunter, Karl, additional, O'Sullivan, Eoin, additional, Bird, Georgina, additional, Magliano, Malgorzata, additional, Manzo, Katarina, additional, Sanghera, Bobbie, additional, Hutchinson, David, additional, Hammonds, Fiona, additional, Sharma, Poonam, additional, Cooper, Richard, additional, McLintock, Graeme, additional, Al-Saffar, Zaid S., additional, Green, Mike, additional, Elliott, Kerry, additional, Neale, Tania, additional, Mallinson, Janine, additional, Lanyon, Peter, additional, Pradere, Marie-Josephe, additional, Jordan, Natasha, additional, Htut, Ei Phyu, additional, Mushapaidzi, Thelma, additional, Abercrombie, Donna, additional, Wright, Sam, additional, Rowlands, Jane, additional, Mukhtyar, Chetan, additional, Kennedy, James, additional, Makkuni, Damodar, additional, Wilhelmsen, Elva, additional, Kouroupis, Michael, additional, John, Lily, additional, Hughes, Rod, additional, Walsh, Margaret, additional, Buckley, Marie, additional, Mackay, Kirsten, additional, Camden-Woodley, Tracey, additional, Redome, Joan, additional, Pearce, Kirsty, additional, Marianayagam, Thiraupathy, additional, Cruz, Carina, additional, Warner, Elizabeth, additional, Atchia, Ishmael, additional, Walker, Claire, additional, Black, Karen, additional, Duffy, Stacey, additional, Fothergill, Lynda, additional, Jefferey, Rebecca, additional, Toomey, Jackie, additional, Rhys-Dillon, Ceril, additional, Pothecary, Carla, additional, Green, Lauren, additional, Toms, Tracey, additional, Maher, Linda, additional, Davis, Diana, additional, Sayan, Amrinder, additional, Thankachen, Mini, additional, Abusalameh, Mahdi, additional, Record, Jessica, additional, Khan, Asad, additional, Stafford, Sam, additional, Hussein, Azza, additional, Williams, Clare, additional, Fletcher, Alison, additional, Johson, Laura, additional, Burnett, Richard, additional, Moots, Robert, additional, Frankland, Helen, additional, Dale, James, additional, Moar, Kirsten, additional, Hollas, Carol, additional, Parker, Ben, additional, Ridings, Derek, additional, Eapen, Sandhya, additional, John, Sindhu, additional, Robson, Jo, additional, Guthrie, Lucy Belle, additional, Fyfe, Rose, additional, Tait, Moira, additional, Marks, Jonathan, additional, Gunter, Emma, additional, Hernandez, Rochelle, additional, Bhat, Smita, additional, Johnston, Paul, additional, Khurshid, Muhammad, additional, Barclay, Charlotte, additional, Kapur, Deepti, additional, Jeffrey, Helen, additional, Hughes, Anna, additional, Slack, Lauren, additional, Thomas, Eleri, additional, Royon, Anna, additional, Hall, Angela, additional, King, Jon, additional, Nyathi, Sindi, additional, Morris, Vanessa, additional, Castelino, Madhura, additional, Hawkins, Ellie, additional, Tomson, Linda, additional, Singh, Animesh, additional, Nunag, Annalyn, additional, O'Connor, Stella, additional, Rushby, Nathan, additional, Hewitson, Nicola, additional, O'Sunmboye, Kenny, additional, Lewszuk, Adam, additional, Boyles, Louise, additional, Perry, Martin, additional, Williams, Emma, additional, Graver, Christine, additional, Defever, Emmanuel, additional, Kamanth, Sanjeet, additional, Kay, Dominic, additional, Ogor, Joe, additional, Winter, Louise, additional, Horton, Sarah, additional, Welch, Gillian, additional, Hollinshead, Kath, additional, Peters, James, additional, Labao, Julius, additional, Dmello, Andrea, additional, Dawson, Julie, additional, Graham, Denise, additional, De Lord, Denise, additional, Deery, Jo, additional, Hazelton, Tracy, additional, Carette, Simon, additional, Chung, Sharon, additional, Cuthbertson, David, additional, Forbess, Lindsy J., additional, Gewurz-Singer, Ora, additional, Hoffman, Gary S., additional, Koening, Curry L., additional, Maksimowicz-McKinnon, Kathleen M., additional, McAlear, Carol A., additional, Moreland, Larry W., additional, Pagnoux, Christian, additional, Seo, Philip, additional, Specks, Ulrich, additional, Spiera, Robert F., additional, Sreih, Antoine, additional, Warrington, Kenneth J., additional, Monach, Paul A., additional, and Weisman, Michael, additional

Published
2024
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9. The Joint Vasculitis Registry in German-speaking countries (GeVas): subgroup analysis of 195 GCA patients

Author

Wallmeier, Pia, primary, Arnold, Sabrina, additional, Tais, Arlette, additional, Ihorst, Gabriele, additional, Janoschke, Marco, additional, Schubach, Fabian, additional, Aries, Peer, additional, Bergner, Raoul, additional, Bremer, Jan Phillip, additional, Görl, Norman, additional, Gutdeutsch, Eva, additional, Hellmich, Bernhard, additional, Henes, Jörg, additional, Hoyer, Bimba Franziska, additional, Kangowski, Antje, additional, Kötter, Ina, additional, Krusche, Martin, additional, Magnus, Tim, additional, Metzler, Claudia, additional, Müller-Ladner, Ulf, additional, Schaier, Matthias, additional, Schönermarck, Ulf, additional, Thiel, Jens, additional, Unger, Leonore, additional, Venhoff, Nils, additional, Weinmann-Menke, Julia, additional, Petersen, Jana, additional, Lamprecht, Peter, additional, and Iking-Konert, Christof, additional

Published
2024
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14. Data quality and patient characteristics in European ANCA-associated vasculitis registries: data retrieval by federated querying

Author

Gisslander, Karl, primary, Rutherford, Matthew, additional, Aslett, Louis, additional, Basu, Neil, additional, Dradin, François, additional, Hederman, Lucy, additional, Hruskova, Zdenka, additional, Kardaoui, Hicham, additional, Lamprecht, Peter, additional, Lichołai, Sabina, additional, Musial, Jacek, additional, O’Sullivan, Declan, additional, Puechal, Xavier, additional, Scott, Jennifer, additional, Segelmark, Mårten, additional, Straka, Richard, additional, Terrier, Benjamin, additional, Tesar, Vladimir, additional, Tesi, Michelangelo, additional, Vaglio, Augusto, additional, Wandrei, Dagmar, additional, White, Arthur, additional, Wójcik, Krzysztof, additional, Yaman, Beyza, additional, Little, Mark A, additional, and Mohammad, Aladdin J, additional

Published
2023
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15. The Joint Vasculitis Registry in German-speaking countries (GeVas): subgroup analysis of 266 AAV-patients

Author

Arnold, Sabrina, primary, Wallmeier, Pia, additional, Tais, Arlette, additional, Ihorst, Gabriele, additional, Janoschke, Marco, additional, Schubach, Fabian, additional, Aries, Peer, additional, Bergner, Raoul, additional, Bremer, Jan Phillip, additional, Görl, Norman, additional, Gutdeutsch, Eva, additional, Hellmich, Bernhard, additional, Henes, Jörg, additional, Hoyer, Bimba Franziska, additional, Kangowski, Antje, additional, Kötter, Ina, additional, Krusche, Martin, additional, Magnus, Tim, additional, Metzler, Claudia, additional, Müller-Ladner, Ulf, additional, Petersen, Jana, additional, Reichelt de Tenorio, Anke, additional, Schaier, Matthias, additional, Schirmer, Jan Henrik, additional, Schönermarck, Ulf, additional, Thiel, Jens, additional, Unger, Leonore, additional, Venhoff, Nils, additional, Weinmann-Menke, Julia, additional, Iking-Konert, Christof, additional, and Lamprecht, Peter, additional

Published
2023
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17. The Joint Vasculitis Registry in German-speaking countries (GeVas) – a prospective, multicenter registry for the follow-up of long-term outcomes in vasculitis

Author

Iking-Konert, Christof, Wallmeier, Pia, Arnold, Sabrina, Adler, Sabine, de Groot, Kirsten, Hellmich, Bernhard, Hoyer, Bimba F., Holl-Ulrich, Konstanze, Ihorst, Gabriele, Kaufmann, Margit, Kötter, Ina, Müller-Ladner, Ulf, Magnus, T., Rech, Jürgen, Schubach, Fabian, Schulze-Koops, Hendrik, Venhoff, Nils, Wiech, Thorsten, Villiger, Peter, and Lamprecht, Peter

Published
2021
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19. The impact of treatment with avacopan on health-related quality of life in antineutrophil cytoplasmic antibody-associated vasculitis: a post-hoc analysis of data from the ADVOCATE trial

Author

Strand, Vibeke, primary, Jayne, David R W, additional, Horomanski, Audra, additional, Yue, Huibin, additional, Bekker, Pirow, additional, Merkel, Peter A, additional, Au Peh, Chen, additional, Chakera, Aron, additional, Cooper, Bruce, additional, Kurtkoti, Jagadeesh, additional, Langguth, Daman, additional, Levidiotis, Vicki, additional, Luxton, Grant, additional, Mount, Peter, additional, Mudge, David, additional, Noble, Euan, additional, Phoon, Richard, additional, Ranganathan, Dwarakanathan, additional, Ritchie, Angus, additional, Ryan, Jessica, additional, Suranyi, Michael, additional, Rosenkranz, Alexander, additional, Lhotta, Karl, additional, Kronbichler, Andreas, additional, Demoulin, Nathalie, additional, Bovy, Christophe, additional, Hellemans, Rachel, additional, Hougardy, Jean-Michel, additional, Sprangers, Ben, additional, Wissing, Karl Martin, additional, Pagnoux, Christian, additional, Barbour, Sean, additional, Brachemi, Soumeya, additional, Cournoyer, Serge, additional, Girard, Louis-Philippe, additional, Laurin, Louis-Philippe, additional, Liang, Patrick, additional, Philibert, David, additional, Walsh, Michael, additional, Tesar, Vladimir, additional, Becvar, Radim, additional, Horak, Pavel, additional, Rychlik, Ivan, additional, Szpirt, Wladimir, additional, Dieperink, Hans, additional, Gregersen, Jon Waarst, additional, Ivarsen, Per, additional, Krarup, Elizabeth, additional, Lyngsoe, Cecilie, additional, Rigothier, Claire, additional, Augusto, Jean-Francois, additional, Belot, Alexandre, additional, Chauveau, Dominique, additional, Cornec, Divi, additional, Jourde-Chiche, Noemie, additional, Ficheux, Maxence, additional, Karras, Alexandre, additional, Klein, Alexandre, additional, Maurier, Francois, additional, Mesbah, Rafik, additional, Moranne, Olivier, additional, Neel, Antoine, additional, Quemeneur, Thomas, additional, Saadoun, David, additional, Terrier, Benjamin, additional, Zaoui, Philippe, additional, Schaier, Matthias, additional, Benck, Urs Tobias, additional, Bergner, Raoul, additional, Busch, Martin, additional, Floege, Juergen, additional, Grundmann, Franziska, additional, Haller, Hermann, additional, Haubitz, Marion, additional, Hellmich, Bernhard, additional, Henes, Joerg Christoph, additional, Hohenstein, Bernd, additional, Hugo, Christian, additional, Iking-Konert, Christof, additional, Arndt, Fabian, additional, Kubacki, T, additional, Kotter, Ina, additional, Lamprecht, Peter, additional, Lindner, Tom, additional, Halbritter, Jan, additional, Mehling, Heidrun, additional, Schönermarck, Ulf, additional, Venhoff, Nils, additional, Vielhauer, Volker, additional, Witzke, Oliver, additional, Szombati, Istvan, additional, Szucs, Gabriella, additional, Garibotto, Giacomo, additional, Alberici, Federico, additional, Brunetta, Enrico, additional, Dagna, Lorenzo, additional, De Vita, Salvatore, additional, Emmi, Giacomo, additional, Gabrielli, Armando, additional, Manenti, Lucio, additional, Pieruzzi, Federico, additional, Roccatello, Dario, additional, Salvarani, Carlo, additional, Harigai, Masayoshi, additional, Dobashi, Hiroaki, additional, Atsumi, Tatsuya, additional, Fujimoto, Shoichi, additional, Hagino, Noboru, additional, Ihata, Atsushi, additional, Kaname, Shinya, additional, Kaneko, Yuko, additional, Katagiri, Akira, additional, Katayama, Masao, additional, Kirino, Yohei, additional, Kitagawa, Kiyoki, additional, Komatsuda, Atsushi, additional, Kono, Hajime, additional, Kurasawa, Takahiko, additional, Matsumura, Ryutaro, additional, Mimura, Toshihide, additional, Morinobu, Akio, additional, Murakawa, Yohko, additional, Naniwa, Taio, additional, Nanki, Toshihiro, additional, Ogawa, Noriyoshi, additional, Oshima, Hisaji, additional, Sada, Kenei, additional, Sugiyama, Eiji, additional, Takeuchi, Tohru, additional, Taki, Hirofumi, additional, Tamura, Naoto, additional, Tsukamoto, Tatsuo, additional, Yamagata, Kunihiro, additional, Yamamura, Masahiro, additional, van Daele, Paulus Leon Arthur, additional, Rutgers, Abraham, additional, Teng, Y.K. Onno, additional, Walker, Robert, additional, Chua, Ignatius, additional, Collins, Michael, additional, Rabindranath, Kannaiyan, additional, de Zoysa, Janak, additional, Svensson, My Hanna Sofia, additional, Grevbo, Bard-Waldum, additional, Kalstad, Synove, additional, Little, Mark, additional, Clarkson, Michael, additional, Molloy, Eamonn, additional, Agraz Pamplona, Irene, additional, Anton, Jordi, additional, Barrio Lucia, Vicente, additional, Ciggaran, Secundino, additional, Cinta Cid, Maria, additional, Diaz Encarnacion, Montserrat, additional, Fulladosa Oliveras, Xavier, additional, Jose Soler, Maria, additional, Marco Rusinol, Helena, additional, Praga, Manuel, additional, Quintana Porras, Luis, additional, Segarra, Alfons, additional, Bruchfeld, Annette, additional, Segelmark, Marten, additional, Soveri, Inga, additional, Thomaidi, Eleni, additional, Westman, Kerstin, additional, Neumann, Thomas, additional, Burnier, Michel, additional, Daikeler, Thomas, additional, Dudler, Jean, additional, Hauser, Thomas, additional, Seeger, Harald, additional, Vogt, Bruno, additional, Burton, James, additional, Al Jayyousi, Reem, additional, Amin, Tania, additional, Andrews, Jacqueline, additional, Baines, Laura Anne, additional, Brogan, Paul, additional, Dasgupta, Bhaskar, additional, Doulton, Timothy William Ronald, additional, Flossmann, Oliver, additional, Griffin, Sian V., additional, Harper, Janice Marian, additional, Harper, Lorraine, additional, Kidder, Dana, additional, Klocke, Rainer, additional, Lanyon, Peter Charles, additional, Luqmani, Raashid, additional, McLaren, John Stuart, additional, Makanjuola, David Osagie, additional, McCann, Liza, additional, Nandagudi, Anupama C., additional, Selvan, Shilpa, additional, O'Riordan, Edmond, additional, Patel, Mumtaz, additional, Patel, Rajan Kantilal, additional, Pusey, Charles Dickson, additional, Rajakariar, Ravindra, additional, Robson, Joanna C., additional, Robson, Michael, additional, Salama, Alan David, additional, Smyth, Lucy, additional, Sznajd, Jan, additional, Taylor, Joanne, additional, Sreih, Antonie G., additional, Belilos, Elise, additional, Bomback, Andrew S., additional, Carlin, Jeffrey, additional, Chang Chen Lin, Yih, additional, Derebail, Vimal K., additional, Dragoi, Serban, additional, Dua, Anisha, additional, Forbess, Lindsy, additional, Geetha, Duvuru, additional, Gipson, Patrick, additional, Gohh, Reginald, additional, Greenwood, Gregory Todd, additional, Hugenberg, Steven T., additional, Jimenez, Richard A.H., additional, Kaskas, Marwan Omar, additional, Kermani, Tanaz, additional, Kivitz, Alan J., additional, Koening, Curry, additional, Langford, Carol A., additional, Marder, Galina, additional, Mohamed, Amr Ahmed El-Huesseini, additional, Monach, Paul, additional, Neyra, Nilda Roxana, additional, Niemer, Gregory W., additional, Niles, John, additional, Obi, Reginald, additional, Owens, Charles, additional, Parks, Deborah L., additional, Podoll, Amber S., additional, Rovin, Brad, additional, Sam, R, additional, Shergy, William Julius, additional, Silva, Arnold Lawrence, additional, Specks, Ulrich, additional, Spiera, Robert, additional, Springer, Jason M., additional, Striebich, Christopher Charles, additional, Swarup, Areena, additional, Thakar, Surabhi, additional, Tiliakos, Athan N., additional, Tsai, Yong, additional, Waguespack, Dia R., additional, and Chester Wasko, Mary, additional

Published
2023
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21. Characteristics and outcome of ANCA-associated vasculitides induced by anti-thyroid drugs: a multicentre retrospective case-control study

Author

Culerrier, Julien, primary, Nguyen, Yann, additional, Karadag, Omer, additional, Yasar Bilge, Sule, additional, Yildrim, Tuba Demirci, additional, Ögüt, Tahir Saygin, additional, Yazisiz, Veli, additional, Bes, Cemal, additional, Celfe, Ayse, additional, Yazici, Ayten, additional, Sadioglu Cagdas, Oznur, additional, Kronbichler, Andreas, additional, Jayne, David, additional, Gauckler, Philipp, additional, Regent, Alexis, additional, Teixeira, Vitor, additional, Marchand-Adam, Sylvain, additional, Duffau, Pierre, additional, Housz-Oro, Saskia Ingen-, additional, Droumaguet, Celine, additional, Andre, Baptiste, additional, Luca, Luminita, additional, Lechtman, Sarah, additional, Aouba, Achille, additional, Lebas, Celine, additional, Servettaz, Amélie, additional, Dernoncourt, Amandine, additional, Ruivard, Marc, additional, Milesi, Anne-Marie, additional, Poindron, Vincent, additional, Jego, Patrick, additional, Padoan, Roberto, additional, Delvino, Paolo, additional, Vandergheynst, Frédéric, additional, Pagnoux, Christian, additional, Yacyshyn, Elaine, additional, Lamprecht, Peter, additional, Flossmann, Oliver, additional, Puéchal, Xavier, additional, and Terrier, Benjamin, additional

Published
2023
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22. Characteristics and outcome of ANCA-associated vasculitides induced by anti-thyroid drugs: a multicenter retrospective case-control study

Author

Karadag, Omer, Culerrier, Julien, Nguyen, Yann, Luca, Luminita, Andre, Baptiste, Droumaguet, Celine, Ingen-Housz-Oro, Saskia, Duffau, Pierre, Marchand-Adam, Sylvain, Teixeira, Vitor, Regent, Alexis, Gauckler, Philipp, Jayne, David, Kronbichler, Andreas, Sadioglu Cagdas, Oznur, Yazici, Ayten, Celfe, Ayse, Yasar Bilge, Sule, Yildrim, TUBA, Ögüt, Tahir Saygin, Yazisiz, Veli, Bes, Cemal, Terrier, Benjamin, Puéchal, Xavier, Flossmann, Oliver, Lamprecht, Peter, Yacyshyn, Elaine, Pagnoux, Christian, Vandergheynst, Frédéric, Delvino, Paolo, Padoan, Roberto, Jego, Patrick, Poindron, Vincent, Milesi, Anne-Marie, Ruivard, Marc, Dernoncourt, Amandine, Servettaz, Amélie, Lebas, Celine, Aouba, Achille, and Lechtman, Sarah

Published
2023

26. COVID-19 pandemic impairs medical care of vasculitis patients in Germany: Results of a national patient survey

Author

Kernder, Anna, primary, Filla, Tim, additional, de Groot, Kirsten, additional, Hellmich, Bernhard, additional, Holle, Julia, additional, Lamprecht, Peter, additional, Moosig, Frank, additional, Ruffer, Nikolas, additional, Specker, Christof, additional, Vordenbäumen, Stefan, additional, Schneider, Matthias, additional, and Chehab, Gamal, additional

Published
2023
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27. GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

Author

Cabral-Marques, Otavio, Marques, Alexandre, Giil, Lasse Melvær, De Vito, Roberta, Rademacher, Judith, Günther, Jeannine, Lange, Tanja, Humrich, Jens Y., Klapa, Sebastian, Schinke, Susanne, Schimke, Lena F., Marschner, Gabriele, Pitann, Silke, Adler, Sabine, Dechend, Ralf, Müller, Dominik N., Braicu, Ioana, Sehouli, Jalid, Schulze-Forster, Kai, Trippel, Tobias, Scheibenbogen, Carmen, Staff, Annetine, Mertens, Peter R., Löbel, Madlen, Mastroianni, Justin, Plattfaut, Corinna, Gieseler, Frank, Dragun, Duska, Engelhardt, Barbara Elizabeth, Fernandez-Cabezudo, Maria J., Ochs, Hans D., al-Ramadi, Basel K., Lamprecht, Peter, Mueller, Antje, Heidecke, Harald, and Riemekasten, Gabriela

Published
2018
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28. Low concentrations of C5a complement receptor antibodies are linked to disease activity and relapse in ANCA ‐associated vasculitis

Author

Klapa, Sebastian, primary, Müller, Antje, additional, Koch, Andreas, additional, Kerstein‐Staehle, Anja, additional, Kähler, Wataru, additional, Heidecke, Harald, additional, Schinke, Susanne, additional, Huber‐Lang, Markus, additional, Nitschke, Martin, additional, Pitann, Silke, additional, Augustin, Solveig, additional, Karsten, Christian M., additional, Riemekasten, Gabriela, additional, and Lamprecht, Peter, additional

Published
2022
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35. Clinical Characteristics and Outcome of ANCA-Associated Vasculitides Induced by Anti-Thyroid Drugs: A Multicenter Retrospective Cohort Study

Author

Jayne, David, Terrier, Benjamin, Puechal, Xavier, Flossmann, Oliver, Lamprecht, Peter, Yacyshyn, Elaine, Pagnoux, Christian, Vandergheynst, Frederic, Delvino, Paolo, Padoan, Roberto, Jego, Patrick, Poindron, Vincent, Milesi, Anne-Marie, Ruivard, Marc, Dernoncourt, Amandine, Servettaz, Amelie, Lebas, Celine, Aouba, Achille, Lechtman, Sarah, Luca, Luminita, Andre, Baptiste, Oro, Saskia, Duffau, Pierre, Marchand-Adam, Sylvain, Teixeira, Vitor, Regent, Alexis, Kronbichler, Andreas, YAZICI, AYTEN, SADİOĞLU ÇAĞDAŞ, ÖZNUR, ÇEFLE, AYŞE, Bes, Cemal, YAZISIZ, VELİ, Ogut, Tahir Saygin, DEMİRCİ YILDIRIM, TUBA, YAŞAR BİLGE, NAZİFE ŞULE, KARADAĞ, ÖMER, Yann Nguyen, Yann Nguyen, and Culerrier, Julien

Published
2022

36. Clustering model of 23 antibodies against G protein-coupled receptors (GPCR) identifies two different subsets of ANCA-associated vasculitis (AAV) with different prognosis

Author

Klapa, Sebastian, Meyer, Carlotta, Müller, Antje, Heideke, Harald, Koch, Andreas, Kähler, Wataru, Riemekasten, Gabriela, and Lamprecht, Peter

Subjects
Medicine and health
Abstract

Introduction: In vivo signatures of antibodies targeting G protein-coupled receptors (GPCR) have been described as a novel immunological feature in healthy individuals and in different diseases (Cabral-Marques O, et al. Nat Commun. 2018). For instance, decreased antibody concentrations against complement-receptors [for full text, please go to the a.m. URL]

Published
2022
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37. Das Gemeinsame Vaskulitis-Register im deutschsprachigen Raum (GeVas) – eine Subgruppenanalyse der 131 RZA-Patienten

Author

Wallmeier, Pia, Arnold, Sabrina, Schubach, Fabian, Ihorst, Gabriele, Dörnbrack, Katharinia, Aries, Peer Malte, Bergner, Raoul, Bremer, Jan Philip, Görl, Norman, Hellmich, Bernhard, Henes, Jörg, Hoyer, Bimba F., Kangowski, Antje, Kötter, Ina, Metzler, Claudia, Müller-Ladner, Ulf, Schaier, Matthias, Schönermark, Ulf, Thiel, Jens, Unger, Leonore, Venhoff, Nils, Weinmann-Menke, Julia, Petersen, Jana, Lamprecht, Peter, and Iking-Konert, Christof

Subjects
Medicine and health
Abstract

Einleitung: Die am häufigsten diagnostizierte Vaskulitis in Deutschland ist die Riesenzellarteriitis (RZA), mit einer Inzidenz von ca. 3,5 pro 100.000 Personen bei Patienten über 50 Jahren, mit steigendem Alter noch häufiger. Wie die meisten Vaskulitiden ist auch die RZA durch chronische [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022
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38. Nomenclature of Cutaneous Vasculitis: Dermatologic Addendum to the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides

Author

Sunderkötter, Cord H., Zelger, Bernhard, Chen, Ko‐Ron, Requena, Luis, Piette, Warren, Carlson, J. Andrew, Dutz, Jan, Lamprecht, Peter, Mahr, Alfred, Aberer, Elisabeth, Werth, Victoria P., Wetter, David A., Kawana, Seiji, Luqmani, Raashid, Frances, Camille, Jorizzo, Joseph, Watts, J. Richard, Metze, Dieter, Caproni, Marzia, Alpsoy, Erkan, Callen, Jeffrey P., Fiorentino, David, Merkel, Peter A., Falk, Ronald J., and Jennette, J. Charles

Published
2018
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40. Low Concentrations of C5a Complement Receptor Antibodies Are Linked to Disease Activity and Relapse in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis.

Author

Klapa, Sebastian, Müller, Antje, Koch, Andreas, Kerstein‐Stähle, Anja, Kähler, Wataru, Heidecke, Harald, Schinke, Susanne, Huber‐Lang, Markus, Nitschke, Martin, Pitann, Silke, Augustin, Solveig, Karsten, Christian M., Riemekasten, Gabriela, and Lamprecht, Peter

Subjects
FLOW cytometry, COMPLEMENT (Immunology), ANTINEUTROPHIL cytoplasmic antibodies, CELL receptors, DISEASE relapse, GRANULOMATOSIS with polyangiitis, NEUTROPHILS, DESCRIPTIVE statistics, SYSTEMIC lupus erythematosus, T cells, VASCULITIS, MICROSCOPIC polyangiitis, MONOCYTES, DISEASE remission, BLOOD
Abstract

Objective: To examine concentrations of circulating antibodies targeting C3a and C5a complement receptors in antineutrophil cytoplasmic autoantibody (ANCA)–associated vasculitis (AAV) and analyze their association with disease activity. Methods: Concentrations of antibodies against C3a and C5a complement receptors (anti‐C3aR and anti‐C5aR) and plasma complement fragments C3a and C5a were determined in patients with AAV (n = 110; granulomatosis with polyangiitis [GPA; n = 82] or microscopic polyangiitis [MPA; n = 28]), systemic lupus erythematosus (SLE) patients as disease controls (n = 36), and healthy donors (n = 220). C3aR and C5aR expression by circulating neutrophils, monocytes, and T cells was analyzed using flow cytometry. Clinical data were assessed at time of serum sampling and during follow‐up for 60 months. Results: In AAV, anti‐C3aR and anti‐C5aR antibodies were decreased (P = 0.0026 and P ≤ 0.0001, respectively). In remission, anti‐C3aR antibody concentrations rose to values comparable to healthy donors, whereas anti‐C5aR antibody concentrations did not. In GPA, anti‐C5a and anti‐C5aR antibody concentrations inversely correlated with each other (r = −0.6831, P = 0.0127). In newly diagnosed GPA, decreased concentrations of anti‐C5aR antibodies but not anti‐C3aR antibodies were associated with disease activity (P = 0.0009). Moreover, low anti‐C5aR antibodies were associated with relapse in GPA (hazard ratio 3.54, P = 0.0009) and MPA (hazard ratio 4.41, P = 0.0041). The frequency of C5aR‐expressing cells within T cell populations was increased in GPA (P = 0.0021 for CD4+ T cells; P = 0.0118 for CD8+ T cells), but not in MPA. Conclusion: Low concentrations of anti‐C5aR antibodies reflect disease activity and are associated with an increased risk for relapse in AAV. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis

Author

Millet, Arnaud, Martin, Katherine R., Bonnefoy, Francis, Saas, Philippe, Mocek, Julie, Alkan, Manal, Terrier, Benjamin, Kerstein, Anja, Tamassia, Nicola, Satyanarayanan, Senthil Kumaran, Ariel, Amiram, Ribeil, Jean-Antoine, Guillevin, Loic, Cassatella, Marco A., Mueller, Antje, Thieblemont, Nathalie, Lamprecht, Peter, Mouthon, Luc, Perruche, Sylvain, and Witko-Sarsat, Veronique

Subjects
Vasculitis -- Genetic aspects -- Development and progression, Proteases -- Properties, Immune response regulation -- Genetic aspects, Health care industry
Abstract

Granulomatosis with polyangiitis (GPA) is a systemic necrotizing vasculitis that is associated with granulomatous inflammation and the presence of anti-neutrophil cytoplasmic antibodies (ANCAs) directed against proteinase 3 (PR3). We previously determined that PR3 on the surface of apoptotic neutrophils interferes with induction of antiinflammatory mechanisms following phagocytosis of these cells by macrophages. Here, we demonstrate that enzymatically active membrane-associated PR3 on apoptotic cells triggered secretion of inflammatory cytokines, including granulocyte CSF (G-CSF) and chemokines. This response required the IL-1R1/MyD88 signaling pathway and was dependent on the synthesis of NO, as macrophages from animals lacking these pathways did not exhibit a PR3-associated proinflammatory response. The PR3-induced microenvironment facilitated recruitment of inflammatory cells, such as macrophages, plasmacytoid DCs (pDCs), and neutrophils, which were observed in close proximity within granulomatous lesions in the lungs of GPA patients. In different murine models of apoptotic cell injection, the PR3-induced microenvironment instructed pDC-driven Th9/Th2 cell generation. Concomitant injection of anti-PR3 ANCAs with PR3-expressing apoptotic cells induced a Th17 response, revealing a GPA-specific mechanism of immune polarization. Accordingly, circulating [CD4.sup.+] T cells from GPA patients had a skewed distribution of Th9/Th2/Th17. These results reveal that PR3 disrupts immune silencing associated with clearance of apoptotic neutrophils and provide insight into how PR3 and PR3-targeting ANCAs promote GPA pathophysiology., Introduction Granulomatosis with polyangiitis (GPA) is a systemic autoimmune disease characterized by granulomatous inflammation and necrotizing vasculitis (1). GPA is associated with anti-neutrophil cytoplasmic antibodies (ANCAs) directed against the neutrophil- [...]

Published
2015
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42. Infektiöse Arthropathien

Author

Lamprecht, Peter, Schölmerich, Jürgen, editor, Burdach, S., editor, Drexler, H., editor, Hallek, M., editor, Hiddemann, W., editor, Hörl, W.H., editor, Klein, H., editor, Landthaler, M., editor, Lenz, K., editor, Mann, K., editor, Mössner, J., editor, Müller-Ladner, U., editor, Reichen, J., editor, Schmiegel, W., editor, Schröder, J.O., editor, Seeger, W., editor, Stremmel, W., editor, Suttorp, N., editor, Weilemann, L.S., editor, and Wöhrle, J.C., editor

Published
2005
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45. Erkrankungen von Knochen, Muskeln und Gelenken

Author

Schröder, Johann O., Müller-Ladner, Ulf, Jens, Schaumburger, Joachim, Grifka, Ulrike, Woenckhaus, Martin, Fleck, Ulrich, Hans-Wolfram, Gödde, Andrea, Lamprecht, Peter, Kneitz, Christian, Tony, Hans-Peter, Glück, Thomas, Wollenhaupt, Jürgen, Harten, Pontus, Von Kempis, Johannes, Schölmerich, Jürgen, editor, Burdach, Stefan, editor, Diehl, Volker, editor, Drexler, Helmut, editor, Hiddemann, Wolfgang, editor, Hörl, Walter H., editor, Klein, Helmfried, editor, Landthaler, Michael, editor, Lenz, Kurt, editor, Mann, Klaus, editor, Mössner, Joachim, editor, Müller-Ladner, Ulf, editor, Reichen, Jürg, editor, Schmiegel, Wolff, editor, Schröder, Johann Oltmann, editor, Seeger, Werner, editor, Stremmel, Wolfgang, editor, Suttorp, Norbert, editor, and Weilemann, L. Sacha, editor

Published
2003
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47. 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for eosinophilic granulomatosis with polyangiitis

Author

Grayson, Peter, Ponte, Cristina, Suppiah, Ravi, Robson, Joanna C., Craven, Anthea, Judge, Andrew, Khalid, Sara, Luqmani, Raashid, Watts, Richard, Merkel, Peter, Hutchings, Andrew, Grayson, Peter C., Luqmani, Raashid A., Merkel, Peter A., Gatenby, Paul, Watts, Richard A., Hill, Catherine, Ranganathan, Dwarakanathan, Kronbichler, Andreas, Blockmans, Daniel, Barra, Lillian, Carette, Simon, Pagnoux, Christian, Dhindsa, Navjot, Fifi-Mah, Aurore, Khalidi, Nader, Liang, Patrick, Milman, Nataliya, Pineau, Christian, Tian, Xinping, Wang, Guochun, Wang, Tian, Zhao, Ming hui, Tesar, Vladimir, Baslund, Bo, Hammam, Nevin, Shahin, Amira, Pirila, Laura, Putaala, Jukka, Hellmich, Bernhard, Henes, Jörg, Lamprecht, Peter, Neumann, Thomas, Schmidt, Wolfgang, Sunderkoetter, Cord, Szekanecz, Zoltan, Danda, Debashish, Das, Siddharth, Gupta, Rajiva, Rajasekhar, Liza, Dobashi, Hiroaki, Sharma, Aman, Wagh, Shrikant, Clarkson, Michael, Kawakami, Tamihiro, Kobayashi, Shigeto, Kono, Hajime, Makino, Hirofumi, Matsui, Kazuo, Muso, Eri, Suzuki, Kazuo, Ikeda, Kei, Takeuchi, Tsutomu, Tsukamoto, Tatsuo, Uchida, Shunya, Wada, Takashi, Yamada, Hidehiro, Yamagata, Kunihiro, Yumura, Wako, Lai, Kan Sow, Flores-Suarez, Luis Felipe, Hinojosa, Andrea, Rutgers, Bram, Tak, Paul Peter, Grainger, Rebecca, Quincey, Vicki, Stamp, Lisa, Besada, Emilio, Diamantopoulos, Andreas, Sznajd, Jan, Azevedo, Elsa, Geraldes, Ruth, Rodrigues, Miguel, Santos, Ernestina, Song, Yeong Wook, Moiseev, Sergey, Hocˇevar, Alojzija, Arimura, Yoshihiro, Cid, Maria Cinta, Moreno, Xavier Solanich, Atukorala, Inoshi, Berglin, Ewa, Molloy, Eamonn, Salvarani, Carlo, Schiavon, Franco, Tombetti, Enrico, Vaglio, Augusto, Amano, Koichi, Fujimoto, Shouichi, Harigai, Masayoshi, Hirano, Fumio, Hirahashi, Junichi, and Honma, Sakae

Abstract

Objective: To develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA). Methods: Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 5 phases: 1) identification of candidate criteria items using consensus methodology, 2) prospective collection of candidate items present at the time of diagnosis, 3) data-driven reduction of the number of candidate items, 4) expert panel review of cases to define the reference diagnosis, and 5) derivation of a points-based risk score for disease classification in a development set using least absolute shrinkage and selection operator logistic regression, with subsequent validation of performance characteristics in an independent set of cases and comparators. Results: The development set for EGPA consisted of 107 cases of EGPA and 450 comparators. The validation set consisted of an additional 119 cases of EGPA and 437 comparators. From 91 candidate items, regression analysis identified 11 items for EPGA, 7 of which were retained. The final criteria and their weights were as follows: maximum eosinophil count ≥1 × 109/liter (+5), obstructive airway disease (+3), nasal polyps (+3), cytoplasmic antineutrophil cytoplasmic antibody (ANCA) or anti–proteinase 3 ANCA positivity (−3), extravascular eosinophilic predominant inflammation (+2), mononeuritis multiplex/motor neuropathy not due to radiculopathy (+1), and hematuria (−1). After excluding mimics of vasculitis, a patient with a diagnosis of small- or medium-vessel vasculitis could be classified as having EGPA if the cumulative score was ≥6 points. When these criteria were tested in the validation data set, the sensitivity was 85% (95% confidence interval [95% CI] 77–91%) and the specificity was 99% (95% CI 98–100%). Conclusion: The 2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for EGPA demonstrate strong performance characteristics and are validated for use in research.

Published
2022

48. Additional file 1 of Both T and B cells are indispensable for the development of a PBMC transfer-induced humanized mouse model for SSc

Author

Shu, Yaqing, Yue, Xiaoyang, Wax, Jacqueline, Kasper, Brigitte, Yin, Junping, Wang, Xiaoqing, Zhang, Liang, Ahmadi, Marjan, Heidecke, Harald, Müller, Antje, Lamprecht, Peter, Yu, Xinhua, Riemekasten, Gabriela, and Petersen, Frank

Abstract

Additional file 1: Supplementary Table 1. Demographic and clinical features of SSc patients recruited for the in vitro T or B cell-depletion. Supplementary Table 2. Overview on medications given to all individual SSc patients with SSc treated with or without immunosuppressive drugs in the present and previous study [5]. Supplementary Figure 1. Efficiency of depletion of human T or B cells from PBMC. Levels of CD3+ T cells (A), CD4+ T cells (B), CD8+ T cells (C), and CD20+ B cells (D) were determined by FACS analysis and presented as % of total human leukocytes in PBMC. Statistical significance of comparison was determined using the paired t test. Supplementary Figure 2. Levels of human leukocytes in peripheral blood of recipient mice. Mice were transferred with whole PBMC, T-cell depleted, or B-cell depleted PBMC, and peripheral blood was taken at the 6th week (A, B) and 12th week (C, D) after the transfer. Subsequently, human CD45+ leukocytes, CD3+ T cells, CD4+ T cells, CD8+ T cells and CD20+ B cells were identified by flow cytometry. Levels of human leukocytes are presented as percentage of total leukocytes including murine and human leukocytes in murine blood. Comparison on levels of human leukocytes indicated between mice transferred with whole PBMC (n = 7) and mice transferred with T-cell depleted PBMC (n = 7) (A) and between mice transferred with whole PBMC (n = 10) and mice transferred with B-cell depleted PBMC (n = 10) (B) by week by the 6th week after the transfer. Comparison on levels of human leukocytes indicated between mice transferred with whole PBMC (n = 4) and mice transferred with T-cell depleted PBMC (n = 4) (C) and between mice transferred with whole PBMC (n = 16) and mice transferred with B-cell depleted PBMC (n = 6) (D) by week by the 12th week after the transfer. P values reflect comparisons between mice transferred with whole PBMC and mice transferred with T- or B-cell depleted PBMC. Statistical significance was determined using the Wilcoxon matched pairs test. Supplementary Figure 3. Presence of ANA in sera of PBMC-transferred mice. Antinuclear antibody (ANA) pattern of murine sera were detected using (HEp-2) cell-based immunofluorescence staining (EUROPattern Suite, Euroimmun, Germany). Two out of 7 mice which received whole PBMC from SSc patients scored positive for ANA, and their ANA patterns were consistent with those of two corresponding SSc patients. By contrast, mice which received T cell-depleted or B cell-depleted PBMC isolated from the 2 SSc patients were ANA negative. Representative micrographs of the ANA test for mice received whole PBMC, T cell-depleted PBMC (PBMC T-/-) or B cell-depleted PBMC (PBMC B-/-) are shown. Supplementary Figure 4. Matrix of Spearman’s correlation coefficients between immunological and histopathological variables. Severity of inflammation in the lung, kidney and liver as well as levels of circulating human CD45+ leukocytes, CD3+ T cells, CD4+ T cells, CD8+ T cells and CD20+ B cells at 6th week after the cell transfer, and levels of total IgG, anti-AT1R IgG and anti-ETAR IgG in sera obtained after the sacrifice of mice were used for the analysis. Samples were tested for normal distribution by using Shapiro-Wilk normality test. Since most variables were not normally distributed, Spearman correlation was applied for the analysis. A color-coded correlation scale is provided on the right of the plot. Blue and ellipses represent negative and positive correlations, respectively, and darker color tones representd larger correlation coefficient magnitudes. Statistically significant differences are indicated by asterisks (*p

Published
2022
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49. The neutrophil: A key resourceful agent in immune‐mediated vasculitis.

Author

Aymonnier, Karen, Amsler, Jennifer, Lamprecht, Peter, Salama, Alan, and Witko‐Sarsat, Véronique

Subjects
BEHCET'S disease, GIANT cell arteritis, POLYARTERITIS nodosa, CARDIOVASCULAR system, VASCULITIS, TAKAYASU arteritis, IMMUNE complexes
Abstract

Summary: The term "vasculitis" refers to a group of rare immune‐mediated diseases characterized by the dysregulated immune system attacking blood vessels located in any organ of the body, including the skin, lungs, and kidneys. Vasculitides are classified according to the size of the vessel that is affected. Although this observation is not specific to small‐, medium‐, or large‐vessel vasculitides, patients show a high circulating neutrophil‐to‐lymphocyte ratio, suggesting the direct or indirect involvement of neutrophils in these diseases. As first responders to infection or inflammation, neutrophils release cytotoxic mediators, including reactive oxygen species, proteases, and neutrophil extracellular traps. If not controlled, this dangerous arsenal can injure the vascular system, which acts as the main transport route for neutrophils, thereby amplifying the initial inflammatory stimulus and the recruitment of immune cells. This review highlights the ability of neutrophils to "set the tone" for immune cells and other cells in the vessel wall. Considering both their long‐established and newly described roles, we extend their functions far beyond their direct host‐damaging potential. We also review the roles of neutrophils in various types of primary vasculitis, including immune complex vasculitis, anti‐neutrophil cytoplasmic antibody‐associated vasculitis, polyarteritis nodosa, Kawasaki disease, giant cell arteritis, Takayasu arteritis, and Behçet's disease. [ABSTRACT FROM AUTHOR]

Published
2023
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