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2. Dynamics of urinary and respiratory shedding of Severe acute respiratory syndrome virus 2 (SARS-CoV-2) RNA excludes urine as a relevant source of viral transmission

Author

Mumm, Jan-Niclas, Ledderose, Stephan, Ostermann, Andreas, Rudelius, Martina, Hellmuth, Johannes C., Münchhoff, Max, Munker, Dieter, Scherer, Clemens, Volz, Yannic, Ebner, Benedikt, Giessen-Jung, Clemens, Lampert, Christopher, Vilsmaier, Theresa, Schneider, Stephanie, Gapp, Madeleine, Milger-Kneidinger, Katrin, Behr, Jürgen, von Bergwelt-Baildon, Michael, Keppler, Oliver T., Stief, Christian, Magistro, Giuseppe, Staehler, Michael, and Rodler, Severin

Published
2022
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8. Gluteal Muscle Fatty Atrophy: An Independent Risk Factor for Surgical Treatment in Elderly Patients Diagnosed with Type-III Fragility Fractures of the Pelvis

Author

Linhart, Christoph, primary, Mehrens, Dirk, additional, Gellert, Luca Maximilian, additional, Ehrnthaller, Christian, additional, Gleich, Johannes, additional, Lampert, Christopher, additional, Lerchenberger, Maximilian, additional, Böcker, Wolfgang, additional, Neuerburg, Carl, additional, and Zhang, Yunjie, additional

Published
2023
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10. Biomechanischer Vergleich am Kadaver des Knochen-Zement-Interphase-Verhaltens von bioresorbierbaren vs. PMMA-Knochenzementen bei osteoporotischen proximalen Femurfrakturen

Author

Linhart, Christoph, Saller, Maximilian, Kassube, Matthias, Kistler, Manuel, Lampert, Christopher, Böcker, Wolfgang, and Ehrnthaller, Christian

Subjects
Zementierung, Mikro-CT, Proximales Femur, ddc: 610, Medicine and health, Bioresorbierbar, PMMA
Abstract

Fragestellung: Die Verwendung von PMMA-Knochenzement zur Augmentation von Osteosynthesematerial hat in den letzten Jahren vermehrt Verbreitung gefunden und wird am proximalen Femur am häufigsten eingesetzt. Die Vorteile der Augmentation am proximalen Femur sind eine höhere biomechanische Primärstabilität [zum vollständigen Text gelangen Sie über die oben angegebene URL]

Published
2022

14. Dynamics of urinary and respiratory shedding of Severe acute respiratory syndrome virus 2 (SARS-CoV-2) RNA excludes urine as a relevant source of viral transmission

Author

Mumm, Jan-Niclas, primary, Ledderose, Stephan, additional, Ostermann, Andreas, additional, Rudelius, Martina, additional, Hellmuth, Johannes C., additional, Münchhoff, Max, additional, Munker, Dieter, additional, Scherer, Clemens, additional, Volz, Yannic, additional, Ebner, Benedikt, additional, Giessen-Jung, Clemens, additional, Lampert, Christopher, additional, Vilsmaier, Theresa, additional, Schneider, Stephanie, additional, Gapp, Madeleine, additional, Milger-Kneidinger, Katrin, additional, Behr, Jürgen, additional, von Bergwelt-Baildon, Michael, additional, Keppler, Oliver T., additional, Stief, Christian, additional, Magistro, Giuseppe, additional, Staehler, Michael, additional, and Rodler, Severin, additional

Published
2021
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16. Attenuated early inflammatory response in solid organ recipients with COVID‐19

Author

Bösch, Florian, primary, Börner, Nikolaus, additional, Kemmner, Stephan, additional, Lampert, Christopher, additional, Jacob, Sven, additional, Koliogiannis, Dionysios, additional, Stangl, Manfred, additional, Michel, Sebastian, additional, Kneidinger, Nikolaus, additional, Schneider, Christian, additional, Fischereder, Michael, additional, Irlbeck, Michael, additional, Denk, Gerald, additional, Werner, Jens, additional, Angele, Martin K., additional, and Guba, Markus O., additional

Published
2020
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20. ITOC2 – 026. A new fusion receptor overcomes PD-1-mediated immunosuppression in adoptive T cell therapy

Author

Schnurr Max, Kraus Fabian, Chaloupka Michael, Rothenfusser Simon, Grassmann Simon, Endres Stefan, Kobold Sebastian, and Lampert Christopher

Subjects
Cancer Research, medicine.medical_treatment, T cell, Peripheral tolerance, Biology, Transduction (genetics), Cytokine, medicine.anatomical_structure, Oncology, Interferon, Immunology, medicine, IL-2 receptor, Receptor, CD8, medicine.drug
Abstract

Background Recent evidence suggests that the co-inhibitory PD-1-PD-L1 axis plays a major role in adoptive T cell therapy failure. We hypothesised that a new fusion receptor reverting PD-1-mediated inhibition into CD28-costimulation may brake peripheral tolerance. Methods Different PD-1-CD28 fusion receptor constructs were created and retrovirally transduced into primary, ovalbumine specific CD8+ T cells (OT-1). Cytokine release, proliferation, cytotoxicity and tumour recognition were analysed in vitro. Anti-tumour efficacy and mode of action were investigated in mice bearing subcutaneous Panc-OVA tumours. Results Transduction of the PD-1-CD28 receptor constructs mediated enhanced cytokine-release, pronounced T cell proliferation and T cell-induced lysis of target tumour cells upon PD-L1 engagement. The PD-1-CD28 receptor function was dependent on two of the CD28-signalling motifs and interferon (IFN)- γ release. Treatment of mice with established Panc-OVA tumours with fusion receptor-transduced OT-1 T cells mediated complete tumour regression in 83% of mice. Mice rejecting the tumour were protected upon subsequent rechallenge with either ovalbumin positive or negative tumours, indicative of a memory response and epitope spreading. Treatment efficacy was associated with accumulation of IFN- γ producing T cells in the tumours. Conclusions Transduction of T cells with this new receptor has the potential of braking the PD-1-PD-L1 immunosuppressive axis in ACT.

Published
2015

21. LETTERS.

Author

Elliott, Joe, Hayes, Lee, Del Carlo, Ranco, Bibring, Lee, Johnson, Tom, Alexander, Delroy, Lampert, Christopher, Loft, Kieron, Smedley, Fraser, Povey, Mark, and Dyson, Neil

Abstract

Several letters to the editor are presented in response to articles in previous issues including about the English football system, one about athlete Fabrizio Ravanelli, and one about the need to put a cap on ticket prices.

Published
2012

22. EMT-related genes are unlikely to be involved in extracapsular growth of lymph node metastases in gastric cancer.

Author

Pretzsch E, Lampert C, Bazhin AV, Link H, Jacob S, Guba M, Werner J, Neumann J, Angele MK, and Bösch F

Subjects
Female, Humans, Male, Middle Aged, Retrospective Studies, Epithelial-Mesenchymal Transition genetics, Extranodal Extension genetics, Lymphatic Metastasis genetics, Stomach Neoplasms genetics, Stomach Neoplasms pathology
Abstract

Background: In gastric cancer (GC), extracapsular growth (ECG) pattern of lymph node metastases is associated with decreased overall survival rates compared to intracapsular lymph node metastases (ICG). Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in hematogenous metastatic spread. Aim of the present study was to analyze if EMT related genes are involved in the growth pattern of lymph node metastases in GC., Methods: Out of our prospective database with 529 patients who underwent surgical resection for GC between 2002 and 2014 forty lymph node positive patients were identified (20 ECG, 20 ICG). The expression of 84 EMT-associated genes were analyzed by RT2 Profiler PCR Array (n = 20). Results were validated by Real-Time PCR (n = 20)., Results: GC with ECG showed differently expressed EMT related genes. GC leading to ECG showed an upregulation of three and downregulation of eleven genes. Those differences, however, could not be confirmed in PCR analysis., Conclusions: This study demonstrates that EMT related genes are not responsible for the different growth patterns of lymph node metastases in GC. Further studies are required to evaluate the underlying mechanisms of ECG in GC as it might provide a potential therapeutic target for this subgroup of more aggressive tumors in the future., (Copyright © 2021 Elsevier GmbH. All rights reserved.)

Published
2022
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