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This paper uses a new dataset on the universe of Canadian imports and tariffs between 1924 and 1936, disaggregated into 1697 goods originating in 112 countries, to analyze the impact on Canadian imports of interwar Canadian trade policy, including the 1932 Ottawa trade agreements. Rather than use a dummy variable approach, we compute the impact of individual tariffs which varied substantially across goods, trade partners, and time. We develop a novel method of controlling for multilateral resistances in the context of a one-country dataset, and perform a variety of counterfactual exercises to determine the impact of tariffs on trade flows. The overall impact of post-1929 tar iff shifts, including the 1932 agreements, was relatively small, reflecting the fact that Canadian trade policy was already highly protectionist: trade agreements can have het erogenous effects on participants because the shocks involved are different. Compared with a free trade counterfactual, the impact of the overall structure of protection on the level and composition of trade was large.

We present a compilation and analysis of 1099 Holocene relative shore-level (RSL) indicators including 867 relative sea-level data points and 232 data points from the Ancylus Lake and the following transitional phase from 10.7 to 8.5 ka BP located around the Baltic Sea. The spatial distribution covers the Baltic Sea and near-coastal areas fairly well, but some gaps remain mainly in Sweden. RSL data follow the standardized HOLSEA format and, thus, are ready for spatially comprehensive applications in, e.g., glacial isostatic adjustment (GIA) modelling. Sampling method The data set is a compilation of rather different samples from geological, geomorphological and archaeological studies. Most of the data was already published in different formats. In this compilation we homogenized the meta information of the available information according to the HOLSEA database format, https://www.holsea.org/archive-your-data, which is a modification of the recommendations given in Hijma et al. (2015). In addition to the reformatting, the majority of samples with radiocarbon dating were recalibrated with oxcal-software using the calib13 and marine13 curves. Furthermore, all sample descriptions were critically checked for consistency in positioning, levelling and indicative meaning by experts of the respective geographic region see Supplement 2. Analytical method In principle, it is a compilation, recalibration and revision of already published data. Data Processing Data of individual compilations were revised and imported into a relational database system. Therein, the data was transferred into the HOLSEA format by specified rules. By this procedure, a homogeneous categorisation was achieved without losing the original data. Also this is stored in the relational database system allowing for later updates of the transfer procedure or a recalibration of the data. Description of data table HOLSEA-baltic-yymmdd.xlsx The workbook in excel format contains 5 sheets, see https://www.holsea.org/archive-your-data: · Long-form, containing the complete information available for each sample · Short-form, a subset of attributes of the Long-form sheet · Radiocarbon, containing the radiocarbon dating information of the respective samples · U-series, a corresponding table containing the respective information of Uranium dating · References, a complete reference list of the primary publications in which the individual data sampling is described. All online sources for the compilation are included in the metadata. A full list of source references is provided in the data description file.

Background In collaboration with state, tribal, local, and territorial health departments, CDC established the U.S. Zika Pregnancy Registry (USZPR) in early 2016 to monitor pregnant women with laboratory evidence of possible recent Zika virus infection and their infants. Methods This report includes an analysis of completed pregnancies (which include live births and pregnancy losses, regardless of gestational age) in the 50 U.S. states and the District of Columbia (DC) with laboratory evidence of possible recent Zika virus infection reported to the USZPR from January 15 to December 27, 2016. Birth defects potentially associated with Zika virus infection during pregnancy include brain abnormalities and/or microcephaly, eye abnormalities, other consequences of central nervous system dysfunction, and neural tube defects and other early brain malformations. Results During the analysis period, 1,297 pregnant women in 44 states were reported to the USZPR. Zika virus-associated birth defects were reported for 51 (5%) of the 972 fetuses/infants from completed pregnancies with laboratory evidence of possible recent Zika virus infection (95% confidence interval [CI] = 4%-7%); the proportion was higher when restricted to pregnancies with laboratory-confirmed Zika virus infection (24/250 completed pregnancies [10%, 95% CI = 7%-14%]). Birth defects were reported in 15% (95% CI = 8%-26%) of fetuses/infants of completed pregnancies with confirmed Zika virus infection in the first trimester. Among 895 liveborn infants from pregnancies with possible recent Zika virus infection, postnatal neuroimaging was reported for 221 (25%), and Zika virus testing of at least one infant specimen was reported for 585 (65%). Conclusions and implications for public health practice These findings highlight why pregnant women should avoid Zika virus exposure. Because the full clinical spectrum of congenital Zika virus infection is not yet known, all infants born to women with laboratory evidence of possible recent Zika virus infection during pregnancy should receive postnatal neuroimaging and Zika virus testing in addition to a comprehensive newborn physical exam and hearing screen. Identification and follow-up care of infants born to women with laboratory evidence of possible recent Zika virus infection during pregnancy and infants with possible congenital Zika virus infection can ensure that appropriate clinical services are available.