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787 results on '"Lamerz, A."'

1. Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Male Mice

Author

Wei-li Chang, Karly Tegang, Benjamin A. Samuels, Michael Saxe, Juergen Wichmann, Denis J. David, Indira Mendez David, Angélique Augustin, Holger Fischer, Sabrina Golling, Jens Lamerz, Doris Roth, Martin Graf, Sannah Zoffmann, Luca Santarelli, Ravi Jagasia, and René Hen

Subjects
Aging, Dentate gyrus, Drug development, Hippocampal neurogenesis, Neurogenic compounds, Pattern separation, Psychiatry, RC435-571
Abstract

Background: Impairments in behavioral pattern separation (BPS)—the ability to distinguish between similar contexts or experiences—contribute to memory interference and overgeneralization seen in many neuropsychiatric conditions, including depression, anxiety, posttraumatic stress disorder, dementia, and age-related cognitive decline. Although BPS relies on the dentate gyrus and is sensitive to changes in adult hippocampal neurogenesis, its significance as a pharmacological target has not been tested. Methods: In this study, we applied a human neural stem cell high-throughput screening cascade to identify compounds that increase human neurogenesis. One compound with a favorable profile, RO6871135, was then tested in young and aged mice for effects on BPS and anxiety-related behaviors. Results: Chronic treatment with RO6871135 (7.5 mg/kg) increased adult hippocampal neurogenesis and improved BPS in a fear discrimination task in both young and aged mice. RO6871135 treatment also lowered innate anxiety-like behavior, which was more apparent in mice exposed to chronic corticosterone. Ablation of adult hippocampal neurogenesis by hippocampal irradiation supported a neurogenesis-dependent mechanism for RO6871135-induced improvements in BPS. To identify possible mechanisms of action, in vitro and in vivo kinase inhibition and chemical proteomics assays were performed. These tests indicated that RO6871135 inhibited CDK8, CDK11, CaMKIIa, CaMKIIb, MAP2K6, and GSK-3β. An analog compound also demonstrated high affinity for CDK8, CaMKIIa, and GSK-3β. Conclusions: These studies demonstrate a method for empirical identification and preclinical testing of novel neurogenic compounds that can improve BPS and point to possible novel mechanisms that can be interrogated for the development of new therapies to improve specific endophenotypes such as impaired BPS.

Published
2025
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3. Pharmacological Enhancement of Adult Hippocampal Neurogenesis Improves Behavioral Pattern Separation in Young and Aged Mice

Author

Chang, Wei-li, primary, Tegang, Karly, additional, Samuels, Benjamin A., additional, Saxe, Michael, additional, Wichmann, Juergen, additional, David, Denis J., additional, David, Indira Mendez, additional, Augustin, Angélique, additional, Fischer, Holger, additional, Golling, Sabrina, additional, Lamerz, Jens, additional, Roth, Doris, additional, Graf, Martin, additional, Zoffmann, Sannah, additional, Santarelli, Luca, additional, Jagasia, Ravi, additional, and Hen, René, additional

Published
2024
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4. Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder

Author

Abdulkadir, Mohamed, Tischfield, Jay A, King, Robert A, Fernandez, Thomas V, Brown, Lawrence W, Cheon, Keun-Ah, Coffey, Barbara J, de Bruijn, Sebastian FTM, Elzerman, Lonneke, Garcia-Delgar, Blanca, Gilbert, Donald L, Grice, Dorothy E, Hagstrøm, Julie, Hedderly, Tammy, Heyman, Isobel, Hong, Hyun Ju, Huyser, Chaim, Ibanez-Gomez, Laura, Kim, Young Key, Kim, Young-Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Lamerz, Andreas, Leventhal, Bennett, Ludolph, Andrea G, Madruga-Garrido, Marcos, Maras, Athanasios, Messchendorp, Marieke D, Mir, Pablo, Morer, Astrid, Münchau, Alexander, Murphy, Tara L, Openneer, Thaïra JC, Plessen, Kerstin J, Rath, Judith JG, Roessner, Veit, Fründt, Odette, Shin, Eun-Young, Sival, Deborah A, Song, Dong-Ho, Song, Jungeun, Stolte, Anne-Marie, Tübing, Jennifer, van den Ban, Els, Visscher, Frank, Wanderer, Sina, Woods, Martin, Zinner, Samuel H, State, Matthew W, Heiman, Gary A, Hoekstra, Pieter J, and Dietrich, Andrea

Subjects
Clinical and Health Psychology, Biomedical and Clinical Sciences, Psychology, Mental Health, Tourette Syndrome, Neurosciences, Neurodegenerative, Pediatric, Clinical Research, Attention Deficit Hyperactivity Disorder (ADHD), Infant Mortality, Serious Mental Illness, Perinatal Period - Conditions Originating in Perinatal Period, Preterm, Low Birth Weight and Health of the Newborn, Brain Disorders, Aetiology, 2.1 Biological and endogenous factors, Mental health, Good Health and Well Being, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Attention Deficit Disorder with Hyperactivity, Case-Control Studies, Child, Child, Preschool, Europe, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Parent-Child Relations, Pregnancy, Pregnancy Complications, Psychiatric Status Rating Scales, Republic of Korea, Retrospective Studies, Severity of Illness Index, Sex Factors, Tic Disorders, United States, Young Adult, Attention-deficit hyperactivity disorder, Delivery, Obsessive-compulsive disorder, Prenatal, Tourette syndrome, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Clinical sciences, Clinical and health psychology
Abstract

Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.

Published
2016

7. De Novo Coding Variants Are Strongly Associated with Tourette Disorder

Author

Abdulkadir, Mohamed, Bohnenpoll, Julia, Bromberg, Yana, Brown, Lawrence W., Cheon, Keun-Ah, Coffey, Barbara J., Deng, Li, Dietrich, Andrea, Dong, Shan, Elzerman, Lonneke, Fernandez, Thomas V., Fründt, Odette, Garcia-Delgar, Blanca, Gedvilaite, Erika, Gilbert, Donald L., Grice, Dorothy E., Hagstrøm, Julie, Hedderly, Tammy, Heiman, Gary A., Heyman, Isobel, Hoekstra, Pieter J., Hong, Hyun Ju, Huyser, Chaim, Ibanez-Gomez, Laura, Kim, Young Key, Kim, Young-Shin, King, Robert A., Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Lamerz, Andreas, Leventhal, Bennett, Ludolph, Andrea G., Lühr da Silva, Claudia, Madruga-Garrido, Marcos, Mandell, Jeffrey D., Maras, Athanasios, Mir, Pablo, Morer, Astrid, Münchau, Alexander, Murphy, Tara L., Nasello, Cara, Openneer, Thaïra J.C., Plessen, Kerstin J., Richer, Petra, Roessner, Veit, Sanders, Stephan, Shin, Eun-Young, Sival, Deborah A., Smith, Louw, Song, Dong-Ho, Song, Jungeun, State, Matthew W., Stolte, Anne Marie, Sun, Nawei, Tischfield, Jay A., Tübing, Jennifer, Visscher, Frank, Walker, Michael F., Wanderer, Sina, Wang, Shuoguo, Willsey, A. Jeremy, Woods, Martin, Xing, Jinchuan, Zhang, Yeting, Zhou, Anbo, Zinner, Samuel H., Barr, Cathy L., Batterson, James R., Berlin, Cheston, Bruun, Ruth D., Budman, Cathy L., Cath, Danielle C., Chouinard, Sylvain, Coppola, Giovanni, Cox, Nancy J., Darrow, Sabrina, Davis, Lea K., Dion, Yves, Freimer, Nelson B., Grados, Marco A., Hirschtritt, Matthew E., Huang, Alden Y., Illmann, Cornelia, Kurlan, Roger, Leckman, James F., Lyon, Gholson J., Malaty, Irene A., Mathews, Carol A., MaMahon, William M., Neale, Benjamin M., Okun, Michael S., Osiecki, Lisa, Pauls, David L., Posthuma, Danielle, Ramensky, Vasily, Robertson, Mary M., Rouleau, Guy A., Sandor, Paul, Scharf, Jeremiah M., Singer, Harvey S., Smit, Jan, Sul, Jae-Hoon, Yu, Dongmei, Sanders, Stephan J., and Samocha, Kaitlin E.

Published
2017
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8. Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

Author

Manaswini Sivaramakrishnan, Kathleen D. McCarthy, Sébastien Campagne, Sylwia Huber, Sonja Meier, Angélique Augustin, Tobias Heckel, Hélène Meistermann, Melanie N. Hug, Pascale Birrer, Ahmed Moursy, Sarah Khawaja, Roland Schmucki, Nikos Berntenis, Nicolas Giroud, Sabrina Golling, Manuel Tzouros, Balazs Banfai, Gonzalo Duran-Pacheco, Jens Lamerz, Ying Hsiu Liu, Thomas Luebbers, Hasane Ratni, Martin Ebeling, Antoine Cléry, Sergey Paushkin, Adrian R. Krainer, Frédéric H.-T. Allain, and Friedrich Metzger

Subjects
Science
Abstract

Small molecules correcting the splicing deficit of the survival of motor neuron 2 (SMN2) gene have been identified as having therapeutic potential. Here, the authors provide evidence that SMN2 mRNA forms a ribonucleoprotein complex that can be specifically targeted by these small molecules.

Published
2017
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9. Supplementary Figure 1 from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines

Author

Augustin, Angélique, primary, Lamerz, Jens, primary, Meistermann, Hélène, primary, Golling, Sabrina, primary, Scheiblich, Stefan, primary, Hermann, Johannes C., primary, Duchateau-Nguyen, Guillemette, primary, Tzouros, Manuel, primary, Avila, David W., primary, Langen, Hanno, primary, Essioux, Laurent, primary, and Klughammer, Barbara, primary

Published
2023
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10. Supplementary Table 1 from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines

Author

Augustin, Angélique, primary, Lamerz, Jens, primary, Meistermann, Hélène, primary, Golling, Sabrina, primary, Scheiblich, Stefan, primary, Hermann, Johannes C., primary, Duchateau-Nguyen, Guillemette, primary, Tzouros, Manuel, primary, Avila, David W., primary, Langen, Hanno, primary, Essioux, Laurent, primary, and Klughammer, Barbara, primary

Published
2023
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11. Data from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines

Author

Augustin, Angélique, primary, Lamerz, Jens, primary, Meistermann, Hélène, primary, Golling, Sabrina, primary, Scheiblich, Stefan, primary, Hermann, Johannes C., primary, Duchateau-Nguyen, Guillemette, primary, Tzouros, Manuel, primary, Avila, David W., primary, Langen, Hanno, primary, Essioux, Laurent, primary, and Klughammer, Barbara, primary

Published
2023
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12. Supplementary Figure 2 from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines

Author

Augustin, Angélique, primary, Lamerz, Jens, primary, Meistermann, Hélène, primary, Golling, Sabrina, primary, Scheiblich, Stefan, primary, Hermann, Johannes C., primary, Duchateau-Nguyen, Guillemette, primary, Tzouros, Manuel, primary, Avila, David W., primary, Langen, Hanno, primary, Essioux, Laurent, primary, and Klughammer, Barbara, primary

Published
2023
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13. Supplementary Methods from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines

Author

Augustin, Angélique, primary, Lamerz, Jens, primary, Meistermann, Hélène, primary, Golling, Sabrina, primary, Scheiblich, Stefan, primary, Hermann, Johannes C., primary, Duchateau-Nguyen, Guillemette, primary, Tzouros, Manuel, primary, Avila, David W., primary, Langen, Hanno, primary, Essioux, Laurent, primary, and Klughammer, Barbara, primary

Published
2023
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16. Impact of non-ionizable lipids and phase mixing methods on structural properties of lipid nanoparticle formulations

Author

Pratsinis, Anna, primary, Fan, Yuchen, additional, Portmann, Michaela, additional, Hammel, Michal, additional, Kou, Ponien, additional, Sarode, Apoorva, additional, Ringler, Philippe, additional, Kovacik, Lubomir, additional, Lauer, Matthias E., additional, Lamerz, Jens, additional, Hura, Greg L., additional, Yen, Chun-Wan, additional, and Keller, Michael, additional

Published
2023
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18. Supplementary Figure 2 from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines

Author

Barbara Klughammer, Laurent Essioux, Hanno Langen, David W. Avila, Manuel Tzouros, Guillemette Duchateau-Nguyen, Johannes C. Hermann, Stefan Scheiblich, Sabrina Golling, Hélène Meistermann, Jens Lamerz, and Angélique Augustin

Abstract

XLSX file - 24K, Statistics of proteins that significantly decrease in their relative abundance with increasing compound concentration, in at least one of the two compounds

Published
2023
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19. Supplementary Figure 1 from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines

Author

Barbara Klughammer, Laurent Essioux, Hanno Langen, David W. Avila, Manuel Tzouros, Guillemette Duchateau-Nguyen, Johannes C. Hermann, Stefan Scheiblich, Sabrina Golling, Hélène Meistermann, Jens Lamerz, and Angélique Augustin

Abstract

PDF file - 60K, Schematic diagram of the experimental framework applied to perform label-free, quantitative chemical proteomics on erlotinib and gefitinib

Published
2023
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20. Data from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines

Author

Barbara Klughammer, Laurent Essioux, Hanno Langen, David W. Avila, Manuel Tzouros, Guillemette Duchateau-Nguyen, Johannes C. Hermann, Stefan Scheiblich, Sabrina Golling, Hélène Meistermann, Jens Lamerz, and Angélique Augustin

Abstract

Although both erlotinib and gefitinib target the EGF receptor (EGFR), erlotinib is effective in patients with EGFR wild-type or mutated tumors, whereas gefitinib is only beneficial for patients with activating mutations. To determine whether these differences in clinical outcomes can be attributed to their respective protein interaction profiles, a label-free, quantitative chemical proteomics study was conducted. Using this method, 24 proteins were highlighted in the binding profiles of erlotinib and gefitinib. Unlike gefinitib, erlotinib displaced the ternary complex formed by integrin-linked kinase (ILK), α-parvin, and PINCH (IPP). The docking of erlotinib in the three-dimensional structure of ILK showed that erlotinib has the ability to bind to the ATP-binding site, whereas gefitinib is unlikely to bind with high affinity. As the IPP complex has been shown to be involved in epithelial-to-mesenchymal transition (EMT) and erlotinib sensitivity has been correlated with EMT status, we used a cellular model of inducible transition and observed that erlotinib prevented EMT in a more efficient way than gefitinib by acting on E-cadherin expression as well as on IPP levels. A retrospective analysis of the MERIT trial indicated that, besides a high level of E-cadherin, a low level of ILK could be linked to clinical benefit with erlotinib. In conclusion, we propose that, in an EGFR wild-type context, erlotinib may have a complementary mode of action by inhibiting IPP complex activities, resulting in the slowing down of the metastatic process of epithelial tumors. Mol Cancer Ther; 12(4); 520–9. ©2013 AACR.

Published
2023
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22. Data from Methylation of Serum DNA Is an Independent Prognostic Marker in Colorectal Cancer

Author

Frank T. Kolligs, Rolf Lamerz, Burkhard Göke, Petra Stieber, Alexander Crispin, Andrea Behrens, Andreas Herbst, and Maike Wallner

Abstract

Purpose: Aberrant CpG island hypermethylation is a feature of a subgroup of colorectal cancers, which can be detected in the serum of affected patients. This study was designed to identify methylation targets with prognostic significance in the serum of patients with colorectal cancer.Experimental Design: In a gene evaluation set consisting of sera from 24 patients with local colorectal cancers, 14 with metastasized disease, and 20 healthy controls, the genes HPP1/TPEF, HLTF, and hMLH1 were identified as potential serum DNA methylation markers. These genes were further analyzed in a test set of sera of 104 patients with colorectal cancer.Results: Methylation of HLTF, HPP1/TPEF, and hMLH1 was found to be significantly correlated with tumor size, and methylation of HLTF and HPP1/TPEF was significantly associated with metastatic disease and tumor stage. Moreover, methylation of HPP1/TPEF was also associated with serum carcinoembryonic antigen. The prognostic relevance of methylation of these genes was tested in pretherapeutic sera of 77 patients with known follow-up. Patients with methylation of HPP1/TPEF or HLTF were found to have unfavorable prognosis (P = 0.001 and 0.008). In contrast, serum methylation of hMLH1 was not associated with a higher risk of death. Multivariate analysis showed methylated HPP1 and/or HLTF serum DNA to be independently associated with poor outcome and a relative risk of death of 3.4 (95% confidence interval, 1.4-8.1; P = 0.007).Conclusions: These data show that the methylation status of specific genes in the serum of patients with colorectal cancer has the potential to become a pretherapeutic predictor of outcome.

Published
2023
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24. Severe Multiorgan Failure Following Yellow Fever Vaccination

Author

Cristina Domingo, Judith Lamerz, Daniel Cadar, Marija Stojkovic, Philip Eisermann, Uta Merle, Andreas Nitsche, and Paul Schnitzler

Subjects
yellow fever virus, vaccination, viscerotropic disease, multiorgan failure, Medicine
Abstract

Background: The yellow fever (YF) vaccination is recommended by the WHO for people traveling or living in endemic areas at risk for yellow fever infections in Africa and South America. Although the live attenuated yellow fever vaccine is a safe and efficient vaccine, rare serious adverse events after vaccination have been reported. Case presentation: We present the case of a 74-year-old male with multiorgan failure after yellow fever vaccination for a trip to Brazil. The patient required admission to the intensive care unit with a prolonged stay due to severe organ dysfunction. Five days after the YF vaccination, the patient experienced nausea, vomiting, diarrhea, and general illness. Three days later he sought medical attention and was transferred to the University Hospital Heidelberg with beginning multiorgan failure and severe septic shock, including hypotonia, tachypnea, thrombopenia, and acute renal failure the same day. Within one week after vaccination, antibodies against YF virus were already detectable and progressively increased over the next two weeks. Viral RNA was detected in serum on the day of admission, with a viral load of 1.0 × 105 copies/mL. The YF virus (YFV) RNA was also present in tracheal secretions for several weeks and could be detected in urine samples up to 20 weeks after vaccination, with a peak viral load of 1.3 × 106 copies/mL. After 20 weeks in the ICU with nine weeks of mechanical ventilation, the patient was transferred to another hospital for further recovery. Conclusions: The risk for severe adverse events due to the YF vaccination should be balanced against the risk of acquiring a severe YF infection, especially in elderly travelers.

Published
2020
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27. Automated Sample Preparation Platform for Mass Spectrometry-Based Plasma Proteomics and Biomarker Discovery

Author

Vilém Guryča, Daniel Roeder, Paolo Piraino, Jens Lamerz, Axel Ducret, Hanno Langen, and Paul Cutler

Subjects
automation, mass spectrometry, plasma, proteomics, Biology (General), QH301-705.5
Abstract

The identification of novel biomarkers from human plasma remains a critical need in order to develop and monitor drug therapies for nearly all disease areas. The discovery of novel plasma biomarkers is, however, significantly hampered by the complexity and dynamic range of proteins within plasma, as well as the inherent variability in composition from patient to patient. In addition, it is widely accepted that most soluble plasma biomarkers for diseases such as cancer will be represented by tissue leakage products, circulating in plasma at low levels. It is therefore necessary to find approaches with the prerequisite level of sensitivity in such a complex biological matrix. Strategies for fractionating the plasma proteome have been suggested, but improvements in sensitivity are often negated by the resultant process variability. Here we describe an approach using multidimensional chromatography and on-line protein derivatization, which allows for higher sensitivity, whilst minimizing the process variability. In order to evaluate this automated process fully, we demonstrate three levels of processing and compare sensitivity, throughput and reproducibility. We demonstrate that high sensitivity analysis of the human plasma proteome is possible down to the low ng/mL or even high pg/mL level with a high degree of technical reproducibility.

Published
2014
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28. Poster

Author

Aleksic, Olivera, Pejovic-Milovancevic, Milica, Popovic-Deusic, Smiljka, Pirgic, Biljana, Sojic, Ivana, Correll, Christoph, Parikh, Umesh, Olshanskiy, Vladimir, Chopra, Bhrigu, Kane, John M., Malhotra, Anil K., Sieslack, Sonja, Barth, Gottfried Maria, Klosinski, Gunther, Sadigorsky, Sheila, Kronenberg, Sefi, Frisch, Amos, Williams, Nicola, Tonge, Bruce, King, Neville, Melvin, Glenn, Dudley, Amanda, Gordon, Michael, Klimkeit, Ester, Hatch, Simon, Breddy, John, DeCory, Heleen, Cameron, Sara, Solanto, Mary, Serra-Pinheiro, Maria, Sousa, Isabella, Mattos, Paulo, Gomes, Fernanda, Pastura, Giuseppe, Milinkovic, Desna, Bilke, Oliver, Kühnel, Sibille, Winterfeld, Bernhard, Campo, John, Perel, James, Axelson, David, Bridge, Jeff, Birmaher, Boris, Ryan, Neal, Brent, David, Sonuga-Barke, Edmund J. S., Sanchez, Dorothea Y., Pavuluri, Mani, Henry, David B., Carbray, Julie A., Sampson, Gwendolyn, Naylor, Michael W., Janicak, Philip G., Gebhardt, Stefan, Theisen, Frank, Haberhausen, Michael, Heinzel-Gutenbrunner, Monika, Wehmeier, Peter, Krieg, Jürgen-Christian, Kühnau, Wolfgang, Schmidtke, Jörg, Remschmidt, Helmut, Hebebrand, Johannes, Clement, Hans-Willi, Fleischhaker, Christian, Hennighausen, Klaus, Schulz, Eberhard, Frank, Reiner, Karamete, Belda, Löndahl, Gunnel, Gustafsson, Peik, Parnegdrd, Anneli, Rigon, Giancarlo, Chiodo, Simona, Mancaruso, Alessandra, Poggioli, Daniele Giovanni, Costa, Stefano, Pires, Pedro, Brito, Isabel, Carvalho, Isabel, Almeida, Sara, Zaragoza, Paula, Shevchenko, Yury, Korneeva, Vasilisa, Stankovic, Miodrag, Lakic, Aneta, Milovanovic, Vesna, Stankovic, Sandra, Hobrücker, Bernard, Caby, Filip, Chambry, Jean, Laudrin, Stéphane, Graindorge, Catherine, Oiji, Arata, Morioka, Yukiko, Murata, Ami, Sato, Madoka, Hashizume, Yume, Müller, Katarina, Werner, Willigis, Martin, Matthias, Mattejat, Eva, Olivieri, Myriam, Simoncini, Annalisa, Marchegiani, Sonia, Muratori, Marco Lazzorotto, Borsetti, Gabriele, Farrag, Shewikar, Coltrinari, Riccardo, Habib, Doa, Fung, Daniel, Lee, Nelson, Ohmann, Susanne, Popow, C., Lanzenberger, M., Herzog, H., Schuch, S., Miksch, S., Abdollahy, Fatemeh, Khani, S., Shabankhani, B., Guerra, Joao, Fontes, Claudia, Martins, Vania, Teles, Ana, Rodrigues, Corina, Correia, Zulmira, Becht-Jördens, Gereon, McElearney, Catherine, Marsh, Michael Fitzgerald Henry, Naumann, Alexander, Holst, Dirk, Engbarth, Annette, Mircea, Tiberiu, Nehra, Ashima, Malhotra, Savita, Chakrabarti, Subho, Kiran, Shashi, Shoba, Srinath, Hvolby, Allan, Jorgensen, Jan Ib, Medeiros, Marco, Correia, Ariete, Gabilondo, Maria, da Silva, Pedro Caldeira, Carreira, Augusto, Yang, Jae-Won, Kim, Yeoung-Rang, Hong, Sung-Do David, Lee, Sang-Sin, Lim, Seong-Hu, Park, Jeoung-Hwan, Trbic, Vera, Boskovic, Danica, Pauschardt, Jan, Mattejat, Fritz, Quaschner, Kurt, Lischka, Erika, Bauer, Mechthild, Petzke, Franka, Wehrmann, Britta, Lesinskiene, Sigita, Paskauskaite, Laura, Bueno, Luisa Garcia-Giralda, Gonzales, Juana Montiel, Cumbres, Javier Gallego, Asensio, Francisco Gutierrez, Denoix, Susanne, Kimmig, Franz, Weinhardt, Marc, Greven, Peter, Buchmann, Stefan, Atas, Nurgül, Jonkanski, Ute, Pisarsky, Bodo, Treuter, Silvia, Cornellà, Josep, Llusent, Alex, Condesso, Lara, Trigueiros, António, Schütz, Klaus, Tarren-Sweeney, Michael, Hazell, Philip, Mazzone, Luigi, Mugno, Diego, Ruta, Liliana, D’Arrigo, Valentina Genitori, Simona, Perrotta Concetta, Mattina, Teresa, Mazzone, Domenico, Nordbeck, Ralf, Gierow, Wolfgang, Haessler, Frank, Buchmann, Johannes, Bliznakova, Lucia, Grimmer, Yvonne, Roth, H. J., Jennen-Steinmetz, Christine, Schmidt, Martin H., Becker, Katja, Ludolph, Andrea G., Storch, Alexander, Boeckers, Tobias, Kirsch, Joachim, Fegert, Jörg M., Drevitska, Oksana, Cianchetti, Carlo, Corona, Simona, Foscoliano, Maria, Contu, Daniela, Fancello, Giuseppina Sannio, Costa, Anna, Roello, Mara, Romano, Angela, Fabrizi, Anna, Pelliccia, Andrea, Matricardi, Maria, Matthias, Nickola, Lesnick, Timo, Gass, Matthias, Su, Linyan, Zhang, Jishui, Wu, Dazing, Luo, Xuerong, Ardizzone, Ignazio, D’Oto, Paola, Priskich, Francesca, Rigillo, Elvira, Tomassetti, Nadia, Vagnoni, Francesca, Sabisch, Beate, Hahne, Anja, Glass, Lisa, Friederici, Angela D., von Suchodoletz, Waldemar, Di Brina, Carlo, Pagnacco, Andrea, Capozzi, Flavia, Penge, Roberta, Bocci, Fabio, Cantonetti, Laura, De Carlo, Alessandra, Scanferla, Barbara, Sebastiani, Teresa, Vagnoni, Cristina, Gao, Xueping, Du, Yasong, Lorenzetti, Fabio, von Aster, Michael, Schweiter, Martin, Kucian, Karin, Loenneker, Thomas, Dietrich, Thomas, Martin-Fiori, Ernst, Abuhegaz, Hesham, Bahary, Hashem, Lee, Dae-Hwan, Kim, Bong-Seog, Jeon, Seong-Ill, Chung, Sun-Lu, da Simoes, Maria Conceicao Taborda, da Dias, Maria Luz Vale, Engqvist, Ulf, Rydelius, Per-Anders, das Formosinho, Maria Dores, Pinto, Ana Monica, Lima, Luiza Nobre, Edbom, Tobias, Larsson, Jan-Olov, Lichtenstein, Paul, Perez, Bernardo, Marin, Macarena, Yang, Su-Jin, Lee, Helen, Noh, Kyung-Sun, Keller, Ferdinand, Goldbeck, Lutz, Benjelloun, Ghizlane, Dhossche, Dirk, Stanfill, Sara, Takahara, Akiko, Kusu, Minemitsu, Watanabe, Sumiko, Matsui, Tatsuya, Ikeda, Kengo, Matsuda, Hiroe, Allik, Hiie, Smedje, Hans, Shirataki, Sadaaki, Murakami, Bonko, Mohamed, Rawheya Ahmad, Dunbar, Fiona, Shea, Sarah, Atsumi, Mariko, Matsumoto, Hideo, Ooya, Akitoshi, Koishi, Seiji, Aoki, Yutaka, Enseki, Youichi, Nakamura, Yuri, Francis, Kostas, Kazaridis, Vassilis, Kirillidou, Panagiota, Koukouvinou, Sofia, Paliwal, Sobharani, Clinic, Parkview, Whitehouse, William, Edwards, Margo, Edwards, Ayliffe, Pandit, Sunita, Powell, Judith, Tehrani-Doost, Mehdi, Sepasi, Mitra, Alaghband-Rad, Javad, Goodarzi, Reza Rad, Kodaira, Masaki, Viertler, Andrea, Elpel, Katja, Reis, Olaf, Akçakn, Melda Ayse, Erden, Gulsen, Kerimoglu, Efser, Lemonnier, Eric, Munesue, Toshio, Mutoh, Kouhei, Shimoda, Kazunori, Nakatani, Hideo, Koshino, Yoshifumi, Germerott, Isabell, Sadek, Eman Galal, Litvinov, A. G., Calderón-Castaneda, Froylan, Nuno-Licona, Alberto Enrique, Alatorre-Miguel, Efren, Goth, Kirstin, Schmeck, Klaus, Winter, Sibylle, Wiegard, Anja, Hinrichs, Günter, Köhler, Denis, Kammerer, Martin, Adams, Diana, von Castelberg, Brida, Taylor, Alyx, Posserud, Maj-Britt, Stormark, Kjell Morten, Lundervold, Astri J., Gillberg, Christopher, Steijnen, Maaike, Verhoeven, Sophie, Francula, Ivana, Prpic, Igor, Volga, Rena, Di Biasi, Stefania, Piperno, Francesca, Puleo, Filomena, Cerracchio, Sara, Giacchè, Roberta, Rein, Zoé, Godart, Nathalie, Perdereau, Fabienne, Curt, Florence, Jeammet, Philippe, Fermanian, Jacques, Bayman, Emine Ozgur, Taneli, Yesim, Guvendeger, Neslim, Ediz, Bulent, Taneli, Suna, Kan, Ismet, Plaß, Angela, Barkmann, Claus, Mack, B., Mittenzwei, K., Riedesser, Peter, Schulte-Markwort, Michael, Roessner, Veit, Becker, Andreas, Hagenberg, Nicola, Berking, Matthias, Banaschewski, Tobias, Rothenberger, Aribert, Coulon, Nathalie, Tardiola, Daniela, Balsamo, Stefano, Capriotti, Nadia, Sandhu, Tanveer, Tamminen, Tuula, Iovchuk, Nina, Milacic, Ivona, Vidojevic, Oliver, Kilincaslan, Ayse, Mukaddes, Nahit Motavalli, Sozen, Gokce, Umut, Ayla, Yamamoto, Kenji, Koishi, Shinko, Natsume, Noriko, Yamazaki, Kosuke, Nanba, Eiji, Naber, Fabienne, van Daalen, Emma, Buitelaar, Jan, van IJzendoorn, Marinus, Willemsen-Swinkels, Sophie, BakermansKranenburg, Marian J., van Engeland, Herman, de Jonge, Maretha, Kemner, Chantal, Caby, Andrea, Bendt, Stefan, Bashina, Vera, Krasnoperova, Maria, Croonenberghs, Jan, Sliwinski, Sonja, Christophe, Armand, Deboutte, Dirk, Maes, Michael, Tosco, Alessia, Giorgi, Emanuela, Lazzarini, Monica, Iorio, M. Liliana, Becciu, Mercedes, Kim, Bung-Nyun, In-Hyoung, Jeong, Ahn, Dong-Hyun, Kim, Boong-Nyun, Shin, Yun-O, Hong, Kang-E, Hrdlicka, Michal, Neuwirth, Jiri, Komarek, Vladimir, Havlovicova, Marketa, Sedlacek, Zdenek, Blatny, Marek, Urbanek, Tomas, Ohta, Masataka, Kano, Yukiko, Nagai, Yoko, Wintgens, Anne, Hayez, Jean-Yves, Lim, Seoung-Hu, Ha, Ji-Hye, Byun, Hee-Jung, Kim, Ji-Hae, Lee, Rebecca, Fombonne, Eric, Taylor, Eric, Çetin, Füsun Çuhadaroôlu, James, Deborah, Lawlor, Maria, Sofroniou, Nick, Kamibeppu, Kiyoko, Sato, Lori, Hoshi, Yasutaka, Zdravkovic, Jezdimir, Kostic, Petar, Murafi, Khalid, Ries, Michael, Siefen, Rainer Georg, Jelinek, Martin, Klimusova, Helena, Blizkovska, Jaroslava, Burke, C., Doody, B., Nix, Carole Müller, Nicole, Ayala, Wilken, Markus, Dunitz-Scheer, Marguerite, Krasnovsky, Alexandra, Dressler, Anastasia, Perelli, Valentina, Tinelli, Francesca, Rafanelli, Valentina, Bargagna, Stefania, Libal, Gerhard, Plener, Paul, Fegert, Jórg M., Enokido, Fumiko, Higuchi, Masako, Jibiki, Istuki, Tomori, Martina, Yoo, Hee-Jeong, Kim, Su-Yeon, Cho, In-Hee, Yune, Sook-Kyeong, Lyoo, In-Kyoon, Ha, Ji-Hyun, Haas, Barbara, Danilova, Lyudmila, Dervic, Kanita, Csorba, Janos, Rozsa, Sandor, Kleinman, Marjorie, Tringer, Laszlo, Friedrich, Max, Gould, Madelyn, Akkaya-Kalayci, Tuerkan, Lenz, Gerhard, Lapponi, Elisa, Filipponi, Maria Carla, Lauria, Felicia, Sogos, Carla, Kitamura, Akihide, Albrecht, Bjoern, Zhang, Xianghui, Li, Xuerong, Hercigonja-Novkovim, Vesna, Kocijan-Hercigonja, Dubravka, Ralston, Stephen, Lorenzo, Maria, Aziz, Asmaa Amin Abdel, Biederman, Joseph, Spencer, Thomas, Moore, Rodney, Gao, Haitao, Cornelld, Josep, Dajcman, Natasa Potocnik, Holnthaner, Rok, Xie, Guangrong, Sühlfleisch-Thurau, Ulrike, Häßler, Frank, Tiffin-Richards, Margaret, Richards, Michael, Hasselhorn, Marcus, Bayrak, Alper, Pereira, R. Rodrigues, Brussel, W., Vlasveld, L., Tuynman-Qua, H. G., Lorenzo, M. J., Song, Dong-Ho, Ha, Eun-Hye, Lee, Eun-Sik, Yu, Young-Min, Weiler, Hans-Theo, Hellrung, Heike, Grünling, Caro, Overmeyer, Stephan, Ligges, Markus, Blanz, Bernhard, Claus, Armin, Walitza, Susanne, Scheuerpflug, Peter, Wewetzer, Christoph, Gerlach, Manfred, Warnke, Andreas, Aoki, Mieko, Aoki, Shozo, Takii, Masato, Uchigata, Yasuko, Nozaki, Takehiro, Kawai, Keisuke, Takakura, Shu, Koreeda, Chikako, Kubo, Chiharu, Saino, Hitoshi, Denda, Kenzo, Ito, Kouichi, Asakura, Satoshi, Sasaki, Yukiya, Sasaki, Fumi, Inoue, Seishiro, Werneck-Rohrer, Sonja, Eveline, Ernst, Eichberger, Heidrun, Prause, Carolin, Schuch, Bibiana, Lamerz, Andreas, Kuepper-Nybelen, Jutta, Wehle, Christine, Trost-Brinkhues, Gabriele, Brenner, Hermann, Herpertz-Dahlmann, Beate, Pawlowska, Beata, Chuchra, Maria, Kaczynska-Haladyj, Marta, Schulze, Ulrike Margarete Elisabeth, Schuler, Simone, Schlamp, Dieter, Schneider, Peter, Reiners, Christian, Morita, Chihiro, Severny, Anatoly, Brutman, Victor, Kireeva, Irina, Schmid, Marc, Zander, Antje, Kaczynska-Haladyi, Marta, Bruning, Nicole, TrostBrinkhues, Gabriele, Popow, Christian, Karwautz, Andreas, Eimecke, Sylvia, Holtkamp, Kristian, Capasso, Anna, Seki, Masaki, Wakabayashi, Yu, Takaoka, Ken, Schmid, Marc G., Zerahn-Hartung, Claudia, Morioka, Kayo, Nedoschill, Jan, Leiberich, Peter, Loew, Thomas, Jung, Jae-Suk, Lee, Young-Sik, Chung, Sun-Ju, Park, Tae-Won, Bettoschi, Alba Sunshine, Carboni, Pasquale, Cho, Soo-Churl, Ahn, Jeong-Mee, Hong, Kang-E., Kassubek, Jan Elena, Quiner, Sylvia, Seyering, Michaela, Friedrich, Max H., Radojkovic, Ana, Velimirovic, Ana, Ali, Sherese, Parker, Kevin, Martinovic, Zarko, Krstic, Nadezda, Buder, Nevenka, Ispanovic, Veronika, Mojs, Ewa, Glowacka, Maria Danuta, Hayashi, Junko, Funakosi, Syunichi, Kamiyama, Takamichi, Ueno, Takashi, Ishii, Tomohiro, Hayashi, Yutaka, Matsuoka, Hiroo, Gardner, William, Lucas, Amanda, Kolko, David, Kelleher, Kelly, Ballabriga, Maria Claustre Jané, Sola, Sergi Ballespi, Dorado, Montse, Reganon, Natalia Diaz, Alonso, Maite Gonzalez, Riba, Maria Dolores, Llaberia, Edelmira Domenech, Ishii, Kayano, Inoko, Kayo, Nishizono-Maher, Aya, Osawa, Makiko, Kasahara, Mari, Saitou, Kazuhiko, Murase, Satomi, Oga, Risa, Murakami, Takashi, Honjo, Shuji, Kaneko, Hitoshi, Arai, Shiori, Völkl-Kernstock, Sabine, Bauch-Prater, Sonja, Feucht, Martha, Vilariça, Paula, Pereira, Isadora, Pastor, Olivia, Farinha, Susana, Caldeira, Pedro, Silva, Maria Antónia, Gawrilow, Caterina, Gollwitzer, Peter M., Cheon, Keun-Ah, Ryu, Young-Hoon, Kim, Jae-won, Filho, Alceu Gomes Correia, Rohde, Luis Augusto, Silva, Tatiana, Bodanese, Rafael, Aman, Michael, Gunning, W. Boudewijn, Laucht, Manfred, El-Faddagh, Mahha, Schmidt, Martin, Nützel, Jakob, Ball, Juliane, Elben, Cornelia, Kadziela-Olech, Halina, Park, Taewon, Im, Myung Ho, Kang, Daehee, Yoo, Hee Jeong, Michelson, David, Zhang, Shuyu, Ruff, Dustin, Feldman, Peter, Bilenberg, Niels, Jensen, Jurgen, Moradi, Azar, Alaey, Vahed, Kratochvil, Christopher, Wilens, Timothy, Greenhill, Laurence, Gelowitz, Douglas, Celestin, Leon Patrice, Celestin-Westreich, Smadar, Banerjee, Somnath, Chandola, M., Venables, S., Negoro, Hideki, Lida, Junzo, Iwasaka, Hidemi, Kyo, Masanori, Nagano, Tatsushi, Kishino, Kanae, Kishimoto, Toshihumi, Kim, Bong-Suk, Hwang, Jun-Won, Kyoh, Masanori, Junzo, Lida, Hideki, Negoro, Tatsushi, Nagano, Kanae, Kishino, Hidemi, Iwasaka, Toshifumi, Kishimoto, Strous, Rael, Kertzman, Simion, Nachum, Z. Ben, Kotler, Moshe, Hegesh, Roni, Coghill, David, Spender, Quentin, Barton, Joanne, Hollis, Chris, Yuen, Cammy, Cleemput, Irina, Annemens, Lieven, Eschmann, Susanne, Käppler, Karl Christoph, Teodoro, Maycoln M. L., Stieger, Eva, Mugier, Anouk, Stüttler, Stephanie, Heise, Cord Alexander, Uebel, Henrik, Hanisch, Charlotte, Konrad, Kerstin, Radach, Ralph, Horn, Dagmar, Tsujii, Noa, Okada, Akira, Kuriki, Noriko, Matsuo, Junko, Hanada, Kazushi, Kusube, Takeshi, Hitomi, Kazuhiko, Schmitz, Marcelo, Denardin, Daniel, da Silva, Tatiana, Pianca, Thiago, Roman, Tatiana, Hutz, Mara, Bouden, Asma, Dengezli, Ines, Halayem, Mohamed, Herreros, Oscar, Sanchez, Francisco, Rubio, Belen, Gracia, Ramon, Weber, Simone Henrike, Wolters, Alex, Allen, Albert J., Kurlan, Roger, Gilbert, Donald, Dunn, David, Sallee, F. Randy, Thomason, Christine, Sutton, Virginia, Milton, Denai, Petersen, Dorthe, Kristensen, Solvejg, Kinkelbur, Jörg, Hellwig, Juliane, Hellwig, Martin, Rüther, Eckert, Omigbodun, Olayinka, Esan, O., Bakare, K., Yusufi, B. O., Nuhu, F., Adesokan, A., Kopecky-Wenzel, Marie, Steenhuis, Mark-Peter, Minderaa, Ruud, Körlof, Marie-Louise, Wängby, Margit, Bergman, Lars R., Yu, Suwei, Multimäki, Petteri, Parkkola, Kai, Sourander, Andre, Nikolakaros, Georgios, Helenius, Hans, Freitas, Carina, Rocha, Assunçâo, Pocinho, Lídia, Arai, Shinichi, Ichikawa, Hironobu, Hirosawa, Ikuko, Mdrquez-Caraveo, Maria Elena, Pérez-Barrón, Verónica, Sorensen, Merete Juul, Mors, Ole, Thomsen, Per Hove, von Klitzing, Kai, Perren, Sonja, von Wyl, Agnes, Burgin, Dieter, Yoo, Han-Ik, Shin, Min-Sup, Hong, Kang E., Syed, Ehsan, Haqqi, Sobia, Semago, Michail, Girdzijauskiene, Sigita, Puras, Dainius, Gintiliene, Grazina, Cerniauskaite, Dovile, Bormann-Kischkel, Christiane, Schmoetzer, Rosemarie, Frischholz, Diana, Linder, Martin, Ganseforth, Catharina, Rödder, Daniela, Kribs, Angela, Pillekamp, Frank, von Gontard, Alexander, Roth, Bernhard, Wiguna, Tjhin, Marques, Cristina Maria Ribeiro, Goldschmidt, Teresa, Cepeda, Teresa, Arman, Ayse, Ersu, Refika, Save, Dilsad, Karaman, Goksin, Karabekiroglu, Koray, Karadag, Bulent, Berkem, Meral, Moller, Lene Ruge, Biswas, Parathasarathy, Malhotra, Anil, Gupta, Nitin, Ivarsson, Tord, Litlere, Oeystein, Svalander, Per, Yelikova, Yelena, Nastasic, Petar, Filipovic, Snezana, Panoski, Roza, Lazetic, Goran, Zvereva, Nataliya, Strauss, Monika, Graf, A., Zollinger, R., Brückl, Tanja, Höfler, Michael, Schwenden, Lena, Wittchen, Hans-Ulrich, Lieb, Roselind, Schweitzer, Angelika, Edwards, Jane, Schlögelhofer, Monika, Amminger, Paul G., Ledda, Maria Giuseppina, Zuddas, A., Piroddi, T., Abis, M., Mereu, A., Härtling, Fabian, Tepest, Ralf, Goncharova, Tanja, Linden, David E. D., Falkei, Peter, Vogeley, Kai, Poustka, Fritz, Spinner, Miriam, Dobranowski, Julian, MacCrimmon, Duncan, Gibson, Jim, Fawcett, Susan, Criollo, Margarita, Ramsauer, Brigitte, Janke, Nina, Djukic, Danica Boskovic, Napoli, Fabiola, Valente, Raffaella, Neri, Valeria, Ferrara, Mauro, Costa, Carla D’Agostini, Veronesi, Christian, Melogno, Sergio, Gigliotti, Achille, Mazzoncini, Bruna, Fonseca, Antonio, Maid, Eva, Hohm, Erika, Mehler-Wex, Claudia, Duvigneau, J. Catharina, Hartl, Romana T., Ben-Shachar, Dorit, Kranzier, Harvey, Kumra, Sanjiv, Gerbino-Rosen, Ginny, Roofeh, David, De Thomas, Courtney, Dombrowski, Carolyn, McMeniman, Marjorie, Chang, Hsueh-Ling, Chen, Sue-Huei, Yu, Keh-Chiang, Kölch, Michael, Bücheler, Reinhild, Gleiter, Christoph H., Bohne, Stephanie P., Häßler, Frank M., Gierow, Bärbel, Carbray, Julie, Gwen, Sampson, Naylor, Michael, Taanila, Anja, Hautala, Katri, Kemppainen, Päivi, Kotimaa, Arto, Ebeling, Hanna, Moilanen, Irma, Biscaldi, Monica, Wagner, Bettina, Dürrwächter, Ute, Trauzettel-Klosinski, Susanne, Reinhard, Jens, Plume, Ellen, Schulte-Körne, Gerd, Aleksic, Branko, Blaser, Regula, Preuss, Ulrich, Meusel, Claudia, Macharey, Georg, Strehlow, Ulrich, Haffner, Johann, Bischof, Jürgen, Gratzka, Volker, Parzer, Peter, Resch, Franz, Sachse, Steffi, Anke, Beatrice, Adamski, Monika, Pecha, Angelika, Macesic-Petrovic, Dragana, Slavnic, Svetlana, Hatagaki, Chie, Swaab, Hanna, Cohen-Kettenis, P., Di Scipio, Roberta, Patruno, Ester, Reinelt-Straka, Sylvia, Hoffmann, Liselotte, Dragana, Max H. Friedrich, Petrovic, Macesic, Nesa, Monique, Hay, David, Roberts, Clare, McCoy, Mairead, Salbach, Harriet, Klopfer, Uta, Hagen, Swantje, Arne, Bürger, Lehmkuhl, Ulrike, Smith, Bradley, Sinzig, Judith, Hohmann, Martin, Mukai, Takayo, Enebrink, Pia, Ldngström, Niklas, Andershed, Henrik, Richer, Louis, Lachance, Lise, Dubé, Claude, Saintonge, Serge, Virkkunen, Matti, Liesivuori, Jyrki, Bloigu, Risto, Tiihonen, Jari, Vance, Alasdair, Prakash, Chidambaram, Reyes-Harde, Magali, Csaba, Krisztina, Eerdekens, Marielle, Olah, Roza, Augustyns, Ilse, Hellmann, Ulrike, Matei, Astrid, Ha, Ji Hyun, Cho, In Hee, Kim, Mee Gyeong, Yune, Sook Kyeong, Lyoo, In Kyoon, Barbro, Bruce, Polanczyk, Guilherme, Iraqi, Zineb, Kadri, Nadia, Moussaoui, Driss, Raddaoui, Kamal, Titze, Karl, Wollenweber, Susanne, Nell, Verena, Wiefel, Andreas, Guex, Margarita Forcada, Sezer, Basaran, Shamsaei, Farshid, Cheraghi, Fatemeh, Hasturk, Oytun, Okan, Mehmet, Sato, Naoko, Sato, Aya, Camillo, Eleonora, Porcari, Viviana, Salatiello, Maria Patrizia, Chifari, Sabrina, Dell’Oglio, Valentina, Rosanna, Militello, Scrò, Carmela, Hart-Kerkhoffs, Lisette, Ph. van Wijk, A., Jansen, L. M. C., Vermeiren, Robert, Doreleijers, Theodore, Zhang, Shi Ji, Latva, Reija, Lehtonen, Liisa, Salmelin, Raili, Tsalamanios, Emmanouel, Kolaitis, Gerasimos, Paliokosta, Elena, Diareine, Stauroula, Anasontzi, Sofia, Tsiantis, Alkis, Limbinaki, Irini, Tsiantis, John, Dreana-Ianciu, Leontina, Vrajitoriu, Miriana, Lebedeva, Laura, Taner, Yasemen, Bakkaloglu, Betul, Çetin, Füsun Çuhadaroâlu, Ozbesler, Cengiz, Erturk, Mihriban, Sebre, Sandra, Keller, Audrey, Borghini, Ayala, Pierrehumbert, Blaise, Ansermet, François, Furnham, Adrian, Noack, Peter, Kirkcaldy, Bruce, Felber, Michaela, Puig, Stefan, Swain, James, Leckman, James, Mayes, Linda, Feldman, Ruth, Constable, Robert, Schultz, Robert, Koren, Evgeny, Trangkasombat, Umaporn, Karle, Michael, Belianchikova, Marina, Scoblo, Galina, Fadeev, Valentin, Jaunin, Lyne, Ansermet, Francois, Ujiie, Tatsuo, Nomura, Kenji, Sasaki, Yasuko, Stancheva-Popkostadinova, Vaska, Achkova, Meglena, Kilic, Emine, Erdogan, Gönül, Gaber, Rami, Qasqas, Areej, Aßhauer, Martin, Adam, Hubertus, Jones, Lynne, Rachidi, Linda, Halty, Kawtar, Battas, Omar, Leor, Agnes, Tyano, Shmuel, Shreiber, Schaul, Hosogane, Nan, Watanabe, Kyoto, Okuyama, Makiko, Kim, Young-Shin, Leventhal, Bennett, Koh, Yun-Joo, Boyce, W. Thomas, Liptai, Sonja, Clauß, Marianne, Heuer, Petra, Kaadan, Abdul Nasser, Menahem, Samuel, Salo-Thompson, Frances, Shabankhani, Bizhan, Hoeger, Christoph, Jeong, Seong-Shim, Park, Jeong-Hwan, Szaniecki, Eduardo, Roll-Pettersson, Lise, Ehnis, Patrick, Trosse, Maria, Van Rebelo, Piedade, Mattson, Eva Heimdahl, Cucchiaro, Giulietta, Cocuzza, Mariadonatella, Morales, Giada, Bobrova, Nataliya, Asbahr, Fernando, Ramos, Renato, Costa, André, Sassi, Roberto, Nauta, Maaike, Tomori, Sonila, Alikaj, Valbona, Como, A., Snider, Lisa, Garvey, Marjorie, Zanetta, Dirce, Elkis, Helio, Swedo, Susan, Vural, Pinar, Wang, Kai, Zhu, Yan, Sabuncuoglu, Osman, Krasavina, Viktoryia, Pykhtareva, Nina, Venuti, Bianca, Tachi, Naohiko, Kodoi, Naomi, Sakamoto, Naoko, Watanabe, Michiko, Goto, Motiko, Geller, Frank, Reinlein, J., Barth, Nikolaus, Hahn, F., Hinney, Anke, Robatzek, Monika, Calvo, Rosa, Luisa, Lazaro, Cirigliano, Lucrezia, Lucarelli, Loredana, Ratz, Uwe, Stegemann, Thomas, Breuer, Ulla, von Widdern, Susanne, Fricke, Leonie, Mitschke, Alexander, Wiater, Alfred, Lehmkuhl, Gerd, Honda, Kyoichi, Lafta, Muhmmad, Kurultak, Secil Oktem, Tomori, S., Petrela, E., Remschmidt, Helmut, editor, and Belfer, Myron L., editor

Published
2004
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32. An Improved Impact Ratio for Identifying Critical Process Parameters in Pharmaceutical Manufacturing Processes

Author

Jens Lamerz, Oana Mihaela Danila, Andreas Schuster, Janine Burren, Christian Moessner, Wolfgang Göhring, Pankaj Rege, Helmut Stahr, Stefan Hildbrand, and Daniel Coleman

Subjects
Biological Products, Pharmaceutical Preparations, Pharmaceutical Science, Technology, Pharmaceutical
Abstract

The identification of critical process parameters in biologics and small molecule process development is a key element of quality by design. The objectivity and consistency of procedures to identify critical process parameters can be improved with the use of impact ratios. Impact ratios quantify a process parameter's practical effect on a critical quality attribute relative to the critical quality attribute's acceptance limits. If the impact ratio is large, i.e., exceeds a predefined impact ratio threshold, the recommendation is to classify the process parameter as a critical process parameter. This article introduces an improved and mathematically well-defined impact ratio. Benefits of this impact ratio are a consistent interpretation for many scenarios commonly encountered in practice, high suitability to automation, and the possibility of standardizing on a single impact ratio definition for pharmaceutical manufacturing.

Published
2022

34. Prevalence of Obesity, Binge Eating, and Night Eating in a Cross-Sectional Field Survey of 6-Year-Old Children and Their Parents in a German Urban Population

Author

Lamerz, Andreas, Kuepper-Nybelen, Jutta, Bruning, Nicole, Wehle, Christine, Trost-Brinkhues, Gabriele, Brenner, Hermann, Hebebrand, Johannes, and Herpertz-Dahlmann, Beate

Abstract

Background: To assess the prevalence of obesity, obesity-related binge eating, non-obesity-related binge eating, and night eating in five- to six-year-old children and to examine the impact of parental eating disturbances. Methods: When 2020 children attended their obligatory health exam prior to school entry in the city of Aachen, Germany, 1979 parents (97.9%) filled out a questionnaire on their child's eating habits and weight development in a cross-sectional survey. Anthropometric measurements were collected for all children in a standardized form. Results: Episodes of binge eating were found in 2.0% of the children surveyed and night eating in 1.1%. There was a significant relationship between binge eating and obesity but not between night eating and the child's weight. Children's binge eating and night eating were strongly associated with eating disturbances on the part of their mothers (adjusted odds ratios [95% confidence intervals]: 6.1 [2.7-13.5] and 7.8 [2.1-29.4], respectively) and with a non-German native language (adjusted odds ratios [95% confidence intervals]: 2.6 [1.2-5.5] and 11.6 [3.5-38.7], respectively). Conclusions: In concurrence with studies on adulthood, binge eating is linked to obesity already in early childhood. Children of mothers with eating disorders and children of mothers with a non-German native language are at increased risk of developing eating disorders themselves. Future studies should focus on obesity and eating disorders in early childhood; prevention programs should seek to target young children at risk as early as possible.

Published
2005
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36. Tumormarker

Author

Lamerz, R., Mann, K., Schmoll, Hans-Joachim, editor, Höffken, Klaus, editor, and Possinger, Kurt, editor

Published
1996
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49. Severe Multiorgan Failure Following Yellow Fever Vaccination

Author

Paul Schnitzler, Philip Eisermann, Daniel Cadar, Judith Lamerz, Andreas Nitsche, Marija Stojkovic, Cristina Domingo, and Uta Merle

Subjects
Pediatrics, medicine.medical_specialty, 030231 tropical medicine, Immunology, Yellow fever vaccine, lcsh:Medicine, Case Report, viscerotropic disease, Tachypnea, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, Drug Discovery, medicine, Pharmacology (medical), 030212 general & internal medicine, ddc:610, Adverse effect, yellow fever virus, multiorgan failure, Pharmacology, business.industry, Yellow fever, lcsh:R, medicine.disease, vaccination, Intensive care unit, Vaccination, Infectious Diseases, Vomiting, medicine.symptom, business, 610 Medizin und Gesundheit, Viral load, medicine.drug
Abstract

Background: The yellow fever (YF) vaccination is recommended by the WHO for people traveling or living in endemic areas at risk for yellow fever infections in Africa and South America. Although the live attenuated yellow fever vaccine is a safe and efficient vaccine, rare serious adverse events after vaccination have been reported. Case presentation: We present the case of a 74-year-old male with multiorgan failure after yellow fever vaccination for a trip to Brazil. The patient required admission to the intensive care unit with a prolonged stay due to severe organ dysfunction. Five days after the YF vaccination, the patient experienced nausea, vomiting, diarrhea, and general illness. Three days later he sought medical attention and was transferred to the University Hospital Heidelberg with beginning multiorgan failure and severe septic shock, including hypotonia, tachypnea, thrombopenia, and acute renal failure the same day. Within one week after vaccination, antibodies against YF virus were already detectable and progressively increased over the next two weeks. Viral RNA was detected in serum on the day of admission, with a viral load of 1.0 × 105 copies/mL. The YF virus (YFV) RNA was also present in tracheal secretions for several weeks and could be detected in urine samples up to 20 weeks after vaccination, with a peak viral load of 1.3 × 106 copies/mL. After 20 weeks in the ICU with nine weeks of mechanical ventilation, the patient was transferred to another hospital for further recovery. Conclusions: The risk for severe adverse events due to the YF vaccination should be balanced against the risk of acquiring a severe YF infection, especially in elderly travelers.

Published
2020

50. Prognosis of patients with hepatocellular carcinoma. Validation and ranking of established staging-systems in a large western HCC-cohort.

Author

Mark op den Winkel, Dorothea Nagel, Julia Sappl, Philip op den Winkel, Rolf Lamerz, Christoph J Zech, Gundula Straub, Thomas Nickel, Markus Rentsch, Petra Stieber, Burkhard Göke, and Frank T Kolligs

Subjects
Medicine, Science
Abstract

BackgroundHCC is diagnosed in approximately half a million people per year, worldwide. Staging is a more complex issue than in most other cancer entities and, mainly due to unique geographic characteristics of the disease, no universally accepted staging system exists to date. Focusing on survival rates we analyzed demographic, etiological, clinical, laboratory and tumor characteristics of HCC-patients in our institution and applied the common staging systems. Furthermore we aimed at identifying the most suitable of the current staging systems for predicting survival.Methodology/principal findingsOverall, 405 patients with HCC were identified from an electronic medical record database. The following seven staging systems were applied and ranked according to their ability to predict survival by using the Akaike information criterion (AIC) and the concordance-index (c-index): BCLC, CLIP, GETCH, JIS, Okuda, TNM and Child-Pugh. Separately, every single variable of each staging system was tested for prognostic meaning in uni- and multivariate analysis. Alcoholic cirrhosis (44.4%) was the leading etiological factor followed by viral hepatitis C (18.8%). Median survival was 18.1 months (95%-CI: 15.2-22.2). Ascites, bilirubin, alkaline phosphatase, AFP, number of tumor nodes and the BCLC tumor extension remained independent prognostic factors in multivariate analysis. Overall, all of the tested staging systems showed a reasonable discriminatory ability. CLIP (closely followed by JIS) was the top-ranked score in terms of prognostic capability with the best values of the AIC and c-index (AIC 2286, c-index 0.71), surpassing other established staging systems like BCLC (AIC 2343, c-index 0.66). The unidimensional scores TNM (AIC 2342, c-index 0.64) and Child-Pugh (AIC 2369, c-index 0.63) performed in an inferior fashion.Conclusions/significanceCompared with six other staging systems, the CLIP-score was identified as the most suitable staging system for predicting prognosis in a large German cohort of predominantly non-surgical HCC-patients.

Published
2012
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