Search

Your search keyword '"Lambourne B"' showing total 8 results
Start Over Author "Lambourne B"
8 results on '"Lambourne B"'

4. 62: A retrospective multicentre audit of outcome among patients with anaplastic lymphoma kinase (ALK) gene rearrangement positive non-small cell lung cancer (NSCLC) who have been treated with crizotinib in England

Author

Yip, K., primary, Conibear, J., additional, Woolf, D., additional, Tarver, K., additional, Willis, B., additional, Hall, S., additional, Sun, F., additional, Kuhan, H., additional, Lambourne, B., additional, Piskilidis, P., additional, Kussaibati, R., additional, Martin, L., additional, Satar, N. Abdul, additional, Gray, C.M.N., additional, Khan, A., additional, Doherty, G., additional, Prewett, S., additional, Smith, M., additional, Dancey, G., additional, Patterson, D.M., additional, Rimmer, Y., additional, Hollingdale, A., additional, Ingle, C., additional, Tasigiannopoulos, Z., additional, Aslam, S., additional, Waite, K., additional, Polychronis, A., additional, Ghafoor, Q., additional, Baijal, S., additional, Newsom-Davis, T., additional, Shah, R., additional, Forster, M., additional, Mulatero, C., additional, Greystoke, A., additional, Postmus, P.E., additional, Blackhall, F., additional, and Gilligan, D., additional

Published
2017
Full Text
View/download PDF

5. 57 Crizotinib in clinical practice: the North East of England's experience

Author

Hall, S., primary, Lambourne, B., additional, Aynsley, E., additional, Gardiner, J., additional, Greystoke, A., additional, Hughes, A., additional, Jones, C., additional, Leaning, D., additional, Li, L., additional, Mansy, T., additional, Margetts, J., additional, Mcdonald, F., additional, Mcmenemin, R., additional, Mulvenna, P., additional, Peedell, C., additional, Shakespeare, D., additional, Simmons, T., additional, Singhal, S., additional, and Turnbull, H., additional

Published
2016
Full Text
View/download PDF

7. Pembrolizumab as a Cause of Cholangiopathy in a Patient With Metastatic Melanoma.

Author

Stuart L, Lambourne B, Turner P, Jones DEJ, Plummer R, Cresti N, and Dyson JK

Subjects
Antineoplastic Agents, Immunological administration & dosage, Antineoplastic Agents, Immunological adverse effects, Cholagogues and Choleretics administration & dosage, Cholangitis, Sclerosing immunology, Cholangitis, Sclerosing therapy, Female, Humans, Liver Function Tests methods, Middle Aged, Neoplasm Staging, Tomography, X-Ray Computed methods, Treatment Outcome, Ursodeoxycholic Acid administration & dosage, Antibodies, Monoclonal, Humanized administration & dosage, Antibodies, Monoclonal, Humanized adverse effects, Glucocorticoids administration & dosage, Hepatitis etiology, Hepatitis immunology, Hepatitis therapy, Melanoma pathology, Melanoma physiopathology, Melanoma therapy, Programmed Cell Death 1 Receptor antagonists & inhibitors, Skin Neoplasms pathology, Skin Neoplasms physiopathology, Skin Neoplasms therapy
Published
2020
Full Text
View/download PDF

8. Desipramine modulation of sigma and opioid peptide receptor expression in glial cells.

Author

Barg J, Belcheva MM, Bem WT, Lambourne B, McLachlan JA, Tolman KC, Johnson FE, and Coscia CJ

Subjects
Animals, Binding Sites, Dihydromorphine metabolism, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Enkephalin, Leucine-2-Alanine metabolism, Enkephalins metabolism, Ethylketocyclazocine metabolism, Etorphine metabolism, Neuroglia cytology, Rats, Receptors, Opioid metabolism, Receptors, Opioid, kappa, Receptors, sigma, Up-Regulation, Desipramine pharmacology, Neuroglia drug effects, Receptors, Opioid drug effects
Abstract

Exposure of C6 glial cell cultures to desipramine induced the appearance of opioid receptors and up-regulated sigma receptors. Opioid binding was demonstrated with 3H-etorphine and 3H-dihydromorphine (DHM), but was not observed with the mu, delta and kappa ligands 3H-DAMGE, 3H-DADLE or 3H-(-)ethylketocyclazocine in the presence of specific blockers, respectively. Competition experiments with 3H-DHM and either (-)naloxone or (+)naloxone indicated the presence of authentic opioid receptors. In similar studies with beta-endorphin, its truncated form (1-27) or their N-acetyl derivatives, beta-endorphin proved to have the highest affinity. Opioid receptors in glial cell aggregates were primarily kappa, with few mu and delta sites. Desipramine increased Bmax values for kappa but not mu and delta.

Published
1991
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results