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292 results on '"Lambert, Bernard"'

1. Automated Scoring to Assess RAD51-Mediated Homologous Recombination in Ovarian Patient-Derived Tumor Organoids

Author

Thorel, Lucie, Elie, Nicolas, Morice, Pierre-Marie, Weiswald, Louis-Bastien, Florent, Romane, Perréard, Marion, Giffard, Florence, Ricou, Agathe, Leman, Raphaël, Babin, Guillaume, Lebrun, Jean-François, Martin, Sandrine, Briand, Mélanie, Lambert, Bernard, Joly, Florence, Blanc-Fournier, Cécile, Vaur, Dominique, Dolivet, Enora, Plancoulaine, Benoit, and Poulain, Laurent

Published
2025
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6. Towards a new standardized method for circulating miRNAs profiling in clinical studies: Interest of the exogenous normalization to improve miRNA signature accuracy

Author

Vigneron, Nicolas, Meryet-Figuière, Matthieu, Guttin, Audrey, Issartel, Jean-Paul, Lambert, Bernard, Briand, Mélanie, Louis, Marie-Hélène, Vernon, Mégane, Lebailly, Pierre, Lecluse, Yannick, Joly, Florence, Krieger, Sophie, Lheureux, Stéphanie, Clarisse, Bénédicte, Leconte, Alexandra, Gauduchon, Pascal, Poulain, Laurent, and Denoyelle, Christophe

Published
2016
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7. Supplementary Figures 1-7, Table 1 and Methods. from Functional miRNA Screening Identifies Wide-ranging Antitumor Properties of miR-3622b-5p and Reveals a New Therapeutic Combination Strategy in Ovarian Tumor Organoids

Author

Vernon, Mégane, primary, Lambert, Bernard, primary, Meryet-Figuière, Matthieu, primary, Brotin, Emilie, primary, Weiswald, Louis-Bastien, primary, Paysant, Hippolyte, primary, Vigneron, Nicolas, primary, Wambecke, Anaïs, primary, Abeilard, Edwige, primary, Giffard, Florence, primary, Louis, Marie-Hélène, primary, Blanc-Fournier, Cécile, primary, Gauduchon, Pascal, primary, Poulain, Laurent, primary, and Denoyelle, Christophe, primary

Published
2023
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17. Micropaleontological investigations in the modern Mahakam delta, East Kalimantan (Indonesia)

Author

Lambert Bernard

Subjects
Indonesia, Kalimantan, Mahakam Delta, fluvial input, tide, drift current, benthonic Foraminifera, biofacies, distribution pattern, Geology, QE1-996.5, Paleontology, QE701-760, Stratigraphy, QE640-699
Abstract

The Mahakam delta is a mixed, fluvial and wave dominated delta located in the eastern part of the island of Borneo (the East Kalimantan province of Indonesia). The distribution of benthic fauna in this delta system is influenced by the combined or antagonistic action of three main parameters: fluvial input of fresh water and sediment, tide, and a strong regional north to south drift current. A model of the present-day faunal distribution has been established taking into account the perturbations induced by the tide and by the regional drift current. This model has been extrapolated into the recent past through the study of shallow cores that permit the reconstruction of late Holocene deltaic regression patterns.

Published
2003

24. Network-Based Integration of Multi-Omics Data Identifies the Determinants of miR-491-5p Effects

Author

Meryet-Figuiere, Matthieu, primary, Vernon, Mégane, additional, Andrianteranagna, Mamy, additional, Lambert, Bernard, additional, Brochen, Célia, additional, Issartel, Jean-Paul, additional, Guttin, Audrey, additional, Gauduchon, Pascal, additional, Brotin, Emilie, additional, Dingli, Florent, additional, Loew, Damarys, additional, Vigneron, Nicolas, additional, Wambecke, Anaïs, additional, Abeilard, Edwige, additional, Barillot, Emmanuel, additional, Poulain, Laurent, additional, Martignetti, Loredana, additional, and Denoyelle, Christophe, additional

Published
2021
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25. The lncRNA ‘UCA1’ modulates the response to chemotherapy of ovarian cancer through direct binding to miR‐27a‐5p and control of UBE2N levels

Author

Wambecke, Anaïs, primary, Ahmad, Mohammad, additional, Morice, Pierre‐Marie, additional, Lambert, Bernard, additional, Weiswald, Louis‐Bastien, additional, Vernon, Mégane, additional, Vigneron, Nicolas, additional, Abeilard, Edwige, additional, Brotin, Emilie, additional, Figeac, Martin, additional, Gauduchon, Pascal, additional, Poulain, Laurent, additional, Denoyelle, Christophe, additional, and Meryet‐Figuiere, Matthieu, additional

Published
2021
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26. Les enseignements du Réseau coupures de combustible

Author

Rigolot, Eric, Etienne, Michel, Lambert, Bernard, Ecologie des Forêts Méditerranéennes (URFM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Retraité, Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Chambre d'Agriculture des Pyrénées Orientales (CA 66), Chambre Régionale d'Agriculture de Midi Pyrénées, Chambre Régionale d'Agriculture d'Occitanie (CRA Occitanie)-Chambre Régionale d'Agriculture d'Occitanie (CRA Occitanie), and Rigolot, Eric

Subjects
[SDE.BE] Environmental Sciences/Biodiversity and Ecology, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, [SDE.MCG] Environmental Sciences/Global Changes, [SDV.EE] Life Sciences [q-bio]/Ecology, environment, [SDE.MCG]Environmental Sciences/Global Changes, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

30. Functional miRNA Screening Identifies Wide-ranging Antitumor Properties of miR-3622b-5p and Reveals a New Therapeutic Combination Strategy in Ovarian Tumor Organoids

Author

Vernon, Mégane, primary, Lambert, Bernard, additional, Meryet-Figuière, Matthieu, additional, Brotin, Emilie, additional, Weiswald, Louis-Bastien, additional, Paysant, Hippolyte, additional, Vigneron, Nicolas, additional, Wambecke, Anaïs, additional, Abeilard, Edwige, additional, Giffard, Florence, additional, Louis, Marie-Hélène, additional, Blanc-Fournier, Cécile, additional, Gauduchon, Pascal, additional, Poulain, Laurent, additional, and Denoyelle, Christophe, additional

Published
2020
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31. Discoaster zonation of the Miocene of the Kutei Basin, East Kalimantan, Indonesia (Mahakam Delta Offshore)

Author

Lambert Bernard and Laporte-Galaa Cécile

Subjects
Indonesia, Borneo, delta, Discoaster, Kutei, Mahakam, Miocene, nannoflora, nannofossil, Neogene, stratigraphy, zonation, Geology, QE1-996.5, Paleontology, QE701-760, Stratigraphy, QE640-699
Abstract

Thirteen time-stratigraphic associations of the nannofossil Discoaster have been defined and used in the Miocene Kutei Basin of eastern Borneo to establish a regional stratigraphic framework. The methodology used is discussed and the fossils employed are figured and annotated. Their aid in resolving the timing, stages and details of delta construction is presented graphically.

Published
2005

33. Predictive Relevance of Circulating miR-622 in Patients with Newly Diagnosed and Recurrent High-Grade Serous Ovarian Carcinoma

Author

Vigneron, Nicolas, primary, Vernon, Mégane, additional, Meryet-Figuière, Matthieu, additional, Lambert, Bernard, additional, Briand, Mélanie, additional, Louis, Marie-Hélène, additional, Krieger, Sophie, additional, Joly, Florence, additional, Lheureux, Stéphanie, additional, Blanc-Fournier, Cécile, additional, Gauduchon, Pascal, additional, Poulain, Laurent, additional, and Denoyelle, Christophe, additional

Published
2020
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34. Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-BclxL strategies through Mcl-1 down-regulation

Author

Bonnefond, Marie-Laure, Florent, Romane, Lenoir, Sophie, Lambert, Bernard, Abeilard, Edwige, Giffard, Florence, Louis, Marie-Hélène, Elie, Nicolas, Briand, Mélanie, Vivien, Denis, Poulain, Laurent, Gauduchon, Pascal, N'Diaye, Monique, Axe BioTICLA, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-CHU Caen, UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER, Physiopathologie et imagerie des troubles neurologiques (PhIND), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Délégation Régionale Normandie du CNRS [Caen], Centre de Microscopie Appliquée à la Biologie [Caen] (CMABio3), Interactions Cellules Organismes Environnement (ICORE), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), The research was supported by the Ligue Contre le Cancer (Comité départemental de l’Orne). Marie-Laure Bonnefond and Romane Florent were funded by a grant from Normandy Regional Council and Marie-Laure Bonnefond was also funded by Accord Healthcare Inc., Bodescot, Myriam, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU)-CHU Caen, and Normandie Université (NU)

Subjects
ovarian cancer, [SDV.CAN] Life Sciences [q-bio]/Cancer, Store-operated calcium channels, ABT-737, [SDV.CAN]Life Sciences [q-bio]/Cancer, MCL-1, mTORC1
Abstract

International audience; The anti-apoptotic proteins Bcl-xL and Mcl-1 have been identified to play a pivotal role in apoptosis resistance in ovarian cancer and constitute key targets for innovative therapeutic strategies. Although BH3-mimetics (i.e. ABT-737) potently inhibit Bcl-xL activity, targeting Mcl-1 remains a hurdle to the success of these strategies. Calcium signaling is profoundly remodeled during carcinogenesis and was reported to activate the signaling pathway controlling Mcl-1 expression. In this context, we investigated the effect of carboxyamidotriazole (CAI), a calcium channel inhibitor used in clinical trials, on Mcl-1 expression. CAI had an anti-proliferative effect on ovarian carcinoma cell lines and strongly down-regulated Mcl-1 expression. It inhibited store-operated calcium entry (SOCE) and Mcl-1 translation through mTORC1 deactivation. Moreover, it sensitized ovarian carcinoma cells to anti-Bcl-xL strategies as their combination elicited massive apoptosis. Its effect on mTORC1 and Mcl-1 was mimicked by the potent SOCE inhibitor, YM58483, which also triggered apoptosis when combined with ABT-737. As a whole, this study suggests that CAI sensitizes to anti-Bcl-xL strategies via its action on Mcl-1 translation and that modulation of SOCE could extend the therapeutic arsenal for treatment of ovarian carcinoma.

Published
2018
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35. Sublingual sugar for hypoglycaemia in children with severe malaria: A pilot clinical study

Author

Giani Sergio, Forster Mathieu, Falquet Jacques, Lambert Bernard, Willcox Merlin L, Dicko Moussa, Graz Bertrand, Diakite Chiaka, Dembele Eugène M, Diallo Drissa, and Barennes Hubert

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Hypoglycaemia is a poor prognostic indicator in severe malaria. Intravenous infusions are rarely feasible in rural areas. The efficacy of sublingual sugar (SLS) was assessed in a pilot randomized controlled trial among hypoglycaemic children with severe malaria in Mali. Methods Of 151 patients with presumed severe malaria, 23 children with blood glucose concentrations < 60 mg/dl (< 3.3 mmol/l) were assigned randomly to receive either intravenous 10% glucose (IVG; n = 9) or sublingual sugar (SLS; n = 14). In SLS, a teaspoon of sugar, moistened with a few drops of water, was gently placed under the tongue every 20 minutes. The child was put in the recovery position. Blood glucose concentration (BGC) was measured every 5–10 minutes for the first hour. All children were treated for malaria with intramuscular artemether. The primary outcome measure was treatment response, defined as reaching a BGC of >= 3.3 mmol/l (60 mg/dl) within 40 minutes after admission. Secondary outcome measures were early treatment response at 20 minutes, relapse (early and late), maximal BGC gain (CGmax), and treatment delay. Results There was no significant difference between the groups in the primary outcome measure. Treatment response occurred in 71% and 67% for SLS and IVG, respectively. Among the responders, relapses occurred in 30% on SLS at 40 minutes and in 17% on IVG at 20 minutes. There was one fatality in each group. Treatment failures in the SLS group were related to children with clenched teeth or swallowing the sugar, whereas in the IVG group, they were due to unavoidable delays in beginning an infusion (median time 17.5 min (range 3–40). Among SLS, the BGC increase was rapid among the nine patients who really kept the sugar sublingually. All but one increased their BGC by 10 minutes with a mean gain of 44 mg/dl (95%CI: 20.5–63.4). Conclusion Sublingual sugar appears to be a child-friendly, well-tolerated and effective promising method of raising blood glucose in severely ill children. More frequent repeated doses are needed to prevent relapse. Children should be monitored for early swallowing which leads to delayed absorption, and in this case another dose of sugar should be given. Sublingual sugar could be proposed as an immediate "first aid" measure while awaiting intravenous glucose. In many cases it may avert the need for intravenous glucose.

Published
2008
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46. Prospect on prescribed burning development in France

Author

Rigolot, Eric, Lambert, Bernard, Ecologie des Forêts Méditerranéennes (URFM), Institut National de la Recherche Agronomique (INRA), Organisme inter-établissements du réseau des chambres d’agriculture du Languedoc-Roussillon - Service d’utilité agricole montagne Méditerranée élevage (OIER SUAMME), and European Forest Institute (EFI). INT.

Subjects
brûlage dirige, Brûlage dirigé, [SDV]Life Sciences [q-bio], Forêt méditerranéenne, Pastoralisme, Gestion du combustible, Brûlage pastoral, brûlage pastoral, forêt méditerranéenne, gestion du combustible, ComputingMilieux_MISCELLANEOUS, pastoralisme
Abstract

International audience

Published
2017

50. Calix[4]arenes as selective extracting agents. An NMR dynamic and conformational investigation of the lanthanide(III) and thorium(IV) complexes

Author

Lambert, Bernard, Jacques, Vincent, Shivanyuk, Alexander, Matthews, Susan E., Tunayar, Abdi, Baaden, Marc, Wipff, Georges, Bohmer, Volker, and Desreux, Jean F.

Subjects
Rare earth metals -- Research, Nuclear magnetic resonance -- Research, Calixarenes -- Research, Chemistry
Abstract

An NMR investigation of the dia- and paramagnetic complexes show that the lanthanide and Th(super 4+) complexes with calix[4]arene ligands substituted either on the narrow or at the wide rim by four coordinating groups behaves totally differently. Nuclear magnetic relaxation dispersion (NMRD) analyses clearly show that these complexes are monomeric in anhydrous acetronitrile.

Published
2000

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