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251 results on '"Lamba, Simona"'

1. DNA demethylation triggers cell free DNA release in colorectal cancer cells

Author

Pessei, Valeria, Macagno, Marco, Mariella, Elisa, Congiusta, Noemi, Battaglieri, Vittorio, Battuello, Paolo, Viviani, Marco, Gionfriddo, Giulia, Lamba, Simona, Lorenzato, Annalisa, Oddo, Daniele, Idrees, Fariha, Cavaliere, Alessandro, Bartolini, Alice, Guarrera, Simonetta, Linnebacher, Michael, Monteonofrio, Laura, Cardone, Luca, Milella, Michele, Bertotti, Andrea, Soddu, Silvia, Grassi, Elena, Crisafulli, Giovanni, Bardelli, Alberto, Barault, Ludovic, and Di Nicolantonio, Federica

Published
2024
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3. Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

Author

Sogari, Alberto, Rovera, Emanuele, Grasso, Gaia, Mariella, Elisa, Reilly, Nicole Megan, Lamba, Simona, Mauri, Gianluca, Durinikova, Erika, Vitiello, Pietro Paolo, Lorenzato, Annalisa, Avolio, Marco, Piumatti, Eleonora, Bonoldi, Emanuela, Aquilano, Maria Costanza, Arena, Sabrina, Sartore-Bianchi, Andrea, Siena, Salvatore, Trusolino, Livio, Donalisio, Manuela, Russo, Mariangela, Di Nicolantonio, Federica, Lembo, David, and Bardelli, Alberto

Published
2024
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4. Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance

Author

Amodio, Vito, Lamba, Simona, Chilà, Rosaria, Cattaneo, Chiara M., Mussolin, Benedetta, Corti, Giorgio, Rospo, Giuseppe, Berrino, Enrico, Tripodo, Claudio, Pisati, Federica, Bartolini, Alice, Aquilano, Maria Costanza, Marsoni, Silvia, Mauri, Gianluca, Marchiò, Caterina, Abrignani, Sergio, Di Nicolantonio, Federica, Germano, Giovanni, and Bardelli, Alberto

Published
2023
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6. Adaptive mutability of colorectal cancers in response to targeted therapies

Author

Russo, Mariangela, Crisafulli, Giovanni, Sogari, Alberto, Reilly, Nicole M., Arena, Sabrina, Lamba, Simona, Bartolini, Alice, Amodio, Vito, Magrì, Alessandro, Novara, Luca, Sarotto, Ivana, Nagel, Zachary D., Piett, Cortt G., Amatu, Alessio, Sartore-Bianchi, Andrea, Siena, Salvatore, Bertotti, Andrea, Trusolino, Livio, Corigliano, Mattia, Gherardi, Marco, Lagomarsino, Marco Cosentino, Di Nicolantonio, Federica, and Bardelli, Alberto

Published
2019

7. Preclinical efficacy of carfilzomib in BRAF‐mutant colorectal cancer models

Author

Maione, Federica, primary, Oddo, Daniele, additional, Galvagno, Federica, additional, Falcomatà, Chiara, additional, Pandini, Marta, additional, Macagno, Marco, additional, Pessei, Valeria, additional, Barault, Ludovic, additional, Gigliotti, Chiara, additional, Mira, Alessia, additional, Corti, Giorgio, additional, Lamba, Simona, additional, Riganti, Chiara, additional, Castella, Barbara, additional, Massaia, Massimo, additional, Rad, Roland, additional, Saur, Dieter, additional, Bardelli, Alberto, additional, and Di Nicolantonio, Federica, additional

Published
2024
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8. Abstract B005: Tolerance to colibactin correlates with response to chemotherapeutic agents in colorectal cancer

Author

Sogari, Alberto, primary, Rovera, Emanuele, additional, Reilly, Nicole Megan, additional, Lamba, Simona, additional, Durinikova, Erika, additional, Lorenzato, Annalisa, additional, Avolio, Marco, additional, Piumatti, Eleonora, additional, Russo, Mariangela, additional, Arena, Sabrina, additional, Trusolino, Livio, additional, Donalisio, Manuela, additional, Nicolantonio, Federica Di, additional, Lembo, David, additional, and Bardelli, Alberto, additional

Published
2024
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9. Dual VEGFA/BRAF targeting boosts PD‐1 blockade in melanoma through GM‐CSF‐mediated infiltration of M1 macrophages

Author

Comunanza, Valentina, primary, Gigliotti, Chiara, additional, Lamba, Simona, additional, Doronzo, Gabriella, additional, Vallariello, Edoardo, additional, Martin, Valentina, additional, Isella, Claudio, additional, Medico, Enzo, additional, Bardelli, Alberto, additional, Sangiolo, Dario, additional, Di Nicolantonio, Federica, additional, and Bussolino, Federico, additional

Published
2023
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10. Abstract 5900: Tolerance to colibactin correlates with response to chemotherapeutic agents in colorectal cancer

Author

Sogari, Alberto, primary, Rovera, Emanuele, additional, Reilly, Nicole Megan, additional, Lamba, Simona, additional, Russo, Mariangela, additional, Lorenzato, Annalisa, additional, Durinikova, Erika, additional, Trusolino, Livio, additional, Arena, Sabrina, additional, Donalisio, Manuela, additional, Nicolantonio, Federica Di, additional, Lembo, David, additional, and Bardelli, Alberto, additional

Published
2023
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11. Supplementary Figure 3 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, Vito, primary, Yaeger, Rona, primary, Arcella, Pamela, primary, Cancelliere, Carlotta, primary, Lamba, Simona, primary, Lorenzato, Annalisa, primary, Arena, Sabrina, primary, Montone, Monica, primary, Mussolin, Benedetta, primary, Bian, Yu, primary, Whaley, Adele, primary, Pinnelli, Marika, primary, Murciano-Goroff, Yonina R., primary, Vakiani, Efsevia, primary, Valeri, Nicola, primary, Liao, Wei-Li, primary, Bhalkikar, Anuja, primary, Thyparambil, Sheeno, primary, Zhao, Hui-Yong, primary, de Stanchina, Elisa, primary, Marsoni, Silvia, primary, Siena, Salvatore, primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Li, Bob T., primary, Rosen, Neal, primary, Di Nicolantonio, Federica, primary, Bardelli, Alberto, primary, and Misale, Sandra, primary

Published
2023
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12. Supplementary Table 2 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, Vito, primary, Yaeger, Rona, primary, Arcella, Pamela, primary, Cancelliere, Carlotta, primary, Lamba, Simona, primary, Lorenzato, Annalisa, primary, Arena, Sabrina, primary, Montone, Monica, primary, Mussolin, Benedetta, primary, Bian, Yu, primary, Whaley, Adele, primary, Pinnelli, Marika, primary, Murciano-Goroff, Yonina R., primary, Vakiani, Efsevia, primary, Valeri, Nicola, primary, Liao, Wei-Li, primary, Bhalkikar, Anuja, primary, Thyparambil, Sheeno, primary, Zhao, Hui-Yong, primary, de Stanchina, Elisa, primary, Marsoni, Silvia, primary, Siena, Salvatore, primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Li, Bob T., primary, Rosen, Neal, primary, Di Nicolantonio, Federica, primary, Bardelli, Alberto, primary, and Misale, Sandra, primary

Published
2023
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13. Supplementary Figure 2 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, Vito, primary, Yaeger, Rona, primary, Arcella, Pamela, primary, Cancelliere, Carlotta, primary, Lamba, Simona, primary, Lorenzato, Annalisa, primary, Arena, Sabrina, primary, Montone, Monica, primary, Mussolin, Benedetta, primary, Bian, Yu, primary, Whaley, Adele, primary, Pinnelli, Marika, primary, Murciano-Goroff, Yonina R., primary, Vakiani, Efsevia, primary, Valeri, Nicola, primary, Liao, Wei-Li, primary, Bhalkikar, Anuja, primary, Thyparambil, Sheeno, primary, Zhao, Hui-Yong, primary, de Stanchina, Elisa, primary, Marsoni, Silvia, primary, Siena, Salvatore, primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Li, Bob T., primary, Rosen, Neal, primary, Di Nicolantonio, Federica, primary, Bardelli, Alberto, primary, and Misale, Sandra, primary

Published
2023
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14. Data from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, Vito, primary, Yaeger, Rona, primary, Arcella, Pamela, primary, Cancelliere, Carlotta, primary, Lamba, Simona, primary, Lorenzato, Annalisa, primary, Arena, Sabrina, primary, Montone, Monica, primary, Mussolin, Benedetta, primary, Bian, Yu, primary, Whaley, Adele, primary, Pinnelli, Marika, primary, Murciano-Goroff, Yonina R., primary, Vakiani, Efsevia, primary, Valeri, Nicola, primary, Liao, Wei-Li, primary, Bhalkikar, Anuja, primary, Thyparambil, Sheeno, primary, Zhao, Hui-Yong, primary, de Stanchina, Elisa, primary, Marsoni, Silvia, primary, Siena, Salvatore, primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Li, Bob T., primary, Rosen, Neal, primary, Di Nicolantonio, Federica, primary, Bardelli, Alberto, primary, and Misale, Sandra, primary

Published
2023
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15. Supplementary Figure 4 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, Vito, primary, Yaeger, Rona, primary, Arcella, Pamela, primary, Cancelliere, Carlotta, primary, Lamba, Simona, primary, Lorenzato, Annalisa, primary, Arena, Sabrina, primary, Montone, Monica, primary, Mussolin, Benedetta, primary, Bian, Yu, primary, Whaley, Adele, primary, Pinnelli, Marika, primary, Murciano-Goroff, Yonina R., primary, Vakiani, Efsevia, primary, Valeri, Nicola, primary, Liao, Wei-Li, primary, Bhalkikar, Anuja, primary, Thyparambil, Sheeno, primary, Zhao, Hui-Yong, primary, de Stanchina, Elisa, primary, Marsoni, Silvia, primary, Siena, Salvatore, primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Li, Bob T., primary, Rosen, Neal, primary, Di Nicolantonio, Federica, primary, Bardelli, Alberto, primary, and Misale, Sandra, primary

Published
2023
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16. Supplementary Table 3 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, Vito, primary, Yaeger, Rona, primary, Arcella, Pamela, primary, Cancelliere, Carlotta, primary, Lamba, Simona, primary, Lorenzato, Annalisa, primary, Arena, Sabrina, primary, Montone, Monica, primary, Mussolin, Benedetta, primary, Bian, Yu, primary, Whaley, Adele, primary, Pinnelli, Marika, primary, Murciano-Goroff, Yonina R., primary, Vakiani, Efsevia, primary, Valeri, Nicola, primary, Liao, Wei-Li, primary, Bhalkikar, Anuja, primary, Thyparambil, Sheeno, primary, Zhao, Hui-Yong, primary, de Stanchina, Elisa, primary, Marsoni, Silvia, primary, Siena, Salvatore, primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Li, Bob T., primary, Rosen, Neal, primary, Di Nicolantonio, Federica, primary, Bardelli, Alberto, primary, and Misale, Sandra, primary

Published
2023
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17. Supplementary Table 1 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, Vito, primary, Yaeger, Rona, primary, Arcella, Pamela, primary, Cancelliere, Carlotta, primary, Lamba, Simona, primary, Lorenzato, Annalisa, primary, Arena, Sabrina, primary, Montone, Monica, primary, Mussolin, Benedetta, primary, Bian, Yu, primary, Whaley, Adele, primary, Pinnelli, Marika, primary, Murciano-Goroff, Yonina R., primary, Vakiani, Efsevia, primary, Valeri, Nicola, primary, Liao, Wei-Li, primary, Bhalkikar, Anuja, primary, Thyparambil, Sheeno, primary, Zhao, Hui-Yong, primary, de Stanchina, Elisa, primary, Marsoni, Silvia, primary, Siena, Salvatore, primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Li, Bob T., primary, Rosen, Neal, primary, Di Nicolantonio, Federica, primary, Bardelli, Alberto, primary, and Misale, Sandra, primary

Published
2023
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18. Supplementary Figure 1 from EGFR Blockade Reverts Resistance to KRASG12C Inhibition in Colorectal Cancer

Author

Amodio, Vito, primary, Yaeger, Rona, primary, Arcella, Pamela, primary, Cancelliere, Carlotta, primary, Lamba, Simona, primary, Lorenzato, Annalisa, primary, Arena, Sabrina, primary, Montone, Monica, primary, Mussolin, Benedetta, primary, Bian, Yu, primary, Whaley, Adele, primary, Pinnelli, Marika, primary, Murciano-Goroff, Yonina R., primary, Vakiani, Efsevia, primary, Valeri, Nicola, primary, Liao, Wei-Li, primary, Bhalkikar, Anuja, primary, Thyparambil, Sheeno, primary, Zhao, Hui-Yong, primary, de Stanchina, Elisa, primary, Marsoni, Silvia, primary, Siena, Salvatore, primary, Bertotti, Andrea, primary, Trusolino, Livio, primary, Li, Bob T., primary, Rosen, Neal, primary, Di Nicolantonio, Federica, primary, Bardelli, Alberto, primary, and Misale, Sandra, primary

Published
2023
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19. Supplementary Figure 2 from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

Author

Gilles, Maud-Emmanuelle, primary, Maione, Federica, primary, Cossutta, Mélissande, primary, Carpentier, Gilles, primary, Caruana, Laure, primary, Di Maria, Silvia, primary, Houppe, Claire, primary, Destouches, Damien, primary, Shchors, Ksenya, primary, Prochasson, Christopher, primary, Mongelard, Fabien, primary, Lamba, Simona, primary, Bardelli, Alberto, primary, Bouvet, Philippe, primary, Couvelard, Anne, primary, Courty, José, primary, Giraudo, Enrico, primary, and Cascone, Ilaria, primary

Published
2023
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20. Supplementary Figure 3 from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

Author

Gilles, Maud-Emmanuelle, primary, Maione, Federica, primary, Cossutta, Mélissande, primary, Carpentier, Gilles, primary, Caruana, Laure, primary, Di Maria, Silvia, primary, Houppe, Claire, primary, Destouches, Damien, primary, Shchors, Ksenya, primary, Prochasson, Christopher, primary, Mongelard, Fabien, primary, Lamba, Simona, primary, Bardelli, Alberto, primary, Bouvet, Philippe, primary, Couvelard, Anne, primary, Courty, José, primary, Giraudo, Enrico, primary, and Cascone, Ilaria, primary

Published
2023
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21. Data from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

Author

Gilles, Maud-Emmanuelle, primary, Maione, Federica, primary, Cossutta, Mélissande, primary, Carpentier, Gilles, primary, Caruana, Laure, primary, Di Maria, Silvia, primary, Houppe, Claire, primary, Destouches, Damien, primary, Shchors, Ksenya, primary, Prochasson, Christopher, primary, Mongelard, Fabien, primary, Lamba, Simona, primary, Bardelli, Alberto, primary, Bouvet, Philippe, primary, Couvelard, Anne, primary, Courty, José, primary, Giraudo, Enrico, primary, and Cascone, Ilaria, primary

Published
2023
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22. Supplementary Figure from Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer

Author

Durinikova, Erika, primary, Reilly, Nicole M., primary, Buzo, Kristi, primary, Mariella, Elisa, primary, Chilà, Rosaria, primary, Lorenzato, Annalisa, primary, Dias, João M. L., primary, Grasso, Gaia, primary, Pisati, Federica, primary, Lamba, Simona, primary, Corti, Giorgio, primary, Degasperi, Andrea, primary, Cancelliere, Carlotta, primary, Mauri, Gianluca, primary, Andrei, Pietro, primary, Linnebacher, Michael, primary, Marsoni, Silvia, primary, Siena, Salvatore, primary, Sartore-Bianchi, Andrea, primary, Nik-Zainal, Serena, primary, Di Nicolantonio, Federica, primary, Bardelli, Alberto, primary, and Arena, Sabrina, primary

Published
2023
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23. Supplementary Material from BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer

Author

Bartolini, Alice, primary, Cardaci, Sabrina, primary, Lamba, Simona, primary, Oddo, Daniele, primary, Marchiò, Caterina, primary, Cassoni, Paola, primary, Amoreo, Carla Azzurra, primary, Corti, Giorgio, primary, Testori, Alessandro, primary, Bussolino, Federico, primary, Pasqualini, Renata, primary, Arap, Wadih, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, and Marchiò, Serena, primary

Published
2023
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24. Data from BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS-Mutant Colorectal Cancer

Author

Bartolini, Alice, primary, Cardaci, Sabrina, primary, Lamba, Simona, primary, Oddo, Daniele, primary, Marchiò, Caterina, primary, Cassoni, Paola, primary, Amoreo, Carla Azzurra, primary, Corti, Giorgio, primary, Testori, Alessandro, primary, Bussolino, Federico, primary, Pasqualini, Renata, primary, Arap, Wadih, primary, Corà, Davide, primary, Di Nicolantonio, Federica, primary, and Marchiò, Serena, primary

Published
2023
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25. Supplementary Materials and Methods and Supplementary Figure Legends from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

Author

Gilles, Maud-Emmanuelle, primary, Maione, Federica, primary, Cossutta, Mélissande, primary, Carpentier, Gilles, primary, Caruana, Laure, primary, Di Maria, Silvia, primary, Houppe, Claire, primary, Destouches, Damien, primary, Shchors, Ksenya, primary, Prochasson, Christopher, primary, Mongelard, Fabien, primary, Lamba, Simona, primary, Bardelli, Alberto, primary, Bouvet, Philippe, primary, Couvelard, Anne, primary, Courty, José, primary, Giraudo, Enrico, primary, and Cascone, Ilaria, primary

Published
2023
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26. Supplementary Figure 5 from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

Author

Gilles, Maud-Emmanuelle, primary, Maione, Federica, primary, Cossutta, Mélissande, primary, Carpentier, Gilles, primary, Caruana, Laure, primary, Di Maria, Silvia, primary, Houppe, Claire, primary, Destouches, Damien, primary, Shchors, Ksenya, primary, Prochasson, Christopher, primary, Mongelard, Fabien, primary, Lamba, Simona, primary, Bardelli, Alberto, primary, Bouvet, Philippe, primary, Couvelard, Anne, primary, Courty, José, primary, Giraudo, Enrico, primary, and Cascone, Ilaria, primary

Published
2023
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27. Supplementary Table 1 from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

Author

Gilles, Maud-Emmanuelle, primary, Maione, Federica, primary, Cossutta, Mélissande, primary, Carpentier, Gilles, primary, Caruana, Laure, primary, Di Maria, Silvia, primary, Houppe, Claire, primary, Destouches, Damien, primary, Shchors, Ksenya, primary, Prochasson, Christopher, primary, Mongelard, Fabien, primary, Lamba, Simona, primary, Bardelli, Alberto, primary, Bouvet, Philippe, primary, Couvelard, Anne, primary, Courty, José, primary, Giraudo, Enrico, primary, and Cascone, Ilaria, primary

Published
2023
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28. Supplementary Figure 4 from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

Author

Gilles, Maud-Emmanuelle, primary, Maione, Federica, primary, Cossutta, Mélissande, primary, Carpentier, Gilles, primary, Caruana, Laure, primary, Di Maria, Silvia, primary, Houppe, Claire, primary, Destouches, Damien, primary, Shchors, Ksenya, primary, Prochasson, Christopher, primary, Mongelard, Fabien, primary, Lamba, Simona, primary, Bardelli, Alberto, primary, Bouvet, Philippe, primary, Couvelard, Anne, primary, Courty, José, primary, Giraudo, Enrico, primary, and Cascone, Ilaria, primary

Published
2023
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29. Supplementary Figure 1 from Nucleolin Targeting Impairs the Progression of Pancreatic Cancer and Promotes the Normalization of Tumor Vasculature

Author

Gilles, Maud-Emmanuelle, primary, Maione, Federica, primary, Cossutta, Mélissande, primary, Carpentier, Gilles, primary, Caruana, Laure, primary, Di Maria, Silvia, primary, Houppe, Claire, primary, Destouches, Damien, primary, Shchors, Ksenya, primary, Prochasson, Christopher, primary, Mongelard, Fabien, primary, Lamba, Simona, primary, Bardelli, Alberto, primary, Bouvet, Philippe, primary, Couvelard, Anne, primary, Courty, José, primary, Giraudo, Enrico, primary, and Cascone, Ilaria, primary

Published
2023
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30. Supplementary Figure 4 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis

Author

Martini, Miriam, primary, Russo, Mariangela, primary, Lamba, Simona, primary, Vitiello, Elisa, primary, Crowley, Emily Hannah, primary, Sassi, Francesco, primary, Romanelli, Davide, primary, Frattini, Milo, primary, Marchetti, Antonio, primary, and Bardelli, Alberto, primary

Published
2023
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32. Supplementary Table 1 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis

Author

Martini, Miriam, primary, Russo, Mariangela, primary, Lamba, Simona, primary, Vitiello, Elisa, primary, Crowley, Emily Hannah, primary, Sassi, Francesco, primary, Romanelli, Davide, primary, Frattini, Milo, primary, Marchetti, Antonio, primary, and Bardelli, Alberto, primary

Published
2023
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33. Supplementary Figure 3 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis

Author

Martini, Miriam, primary, Russo, Mariangela, primary, Lamba, Simona, primary, Vitiello, Elisa, primary, Crowley, Emily Hannah, primary, Sassi, Francesco, primary, Romanelli, Davide, primary, Frattini, Milo, primary, Marchetti, Antonio, primary, and Bardelli, Alberto, primary

Published
2023
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34. Supplementary Table 2 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis

Author

Martini, Miriam, primary, Russo, Mariangela, primary, Lamba, Simona, primary, Vitiello, Elisa, primary, Crowley, Emily Hannah, primary, Sassi, Francesco, primary, Romanelli, Davide, primary, Frattini, Milo, primary, Marchetti, Antonio, primary, and Bardelli, Alberto, primary

Published
2023
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36. Supplementary Figure 1 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis

Author

Martini, Miriam, primary, Russo, Mariangela, primary, Lamba, Simona, primary, Vitiello, Elisa, primary, Crowley, Emily Hannah, primary, Sassi, Francesco, primary, Romanelli, Davide, primary, Frattini, Milo, primary, Marchetti, Antonio, primary, and Bardelli, Alberto, primary

Published
2023
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37. Supplementary Figure 2 from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis

Author

Martini, Miriam, primary, Russo, Mariangela, primary, Lamba, Simona, primary, Vitiello, Elisa, primary, Crowley, Emily Hannah, primary, Sassi, Francesco, primary, Romanelli, Davide, primary, Frattini, Milo, primary, Marchetti, Antonio, primary, and Bardelli, Alberto, primary

Published
2023
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38. Supplementary Figure Legend from Mixed Lineage Kinase MLK4 Is Activated in Colorectal Cancers Where It Synergistically Cooperates with Activated RAS Signaling in Driving Tumorigenesis

Author

Martini, Miriam, primary, Russo, Mariangela, primary, Lamba, Simona, primary, Vitiello, Elisa, primary, Crowley, Emily Hannah, primary, Sassi, Francesco, primary, Romanelli, Davide, primary, Frattini, Milo, primary, Marchetti, Antonio, primary, and Bardelli, Alberto, primary

Published
2023
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41. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth

Author

Germano, Giovanni, Lamba, Simona, Rospo, Giuseppe, Barault, Ludovic, Magrì, Alessandro, Maione, Federica, Russo, Mariangela, Crisafulli, Giovanni, Bartolini, Alice, Lerda, Giulia, Siravegna, Giulia, Mussolin, Benedetta, Frapolli, Roberta, Montone, Monica, Morano, Federica, de Braud, Filippo, Amirouchene-Angelozzi, Nabil, Marsoni, Silvia, D’Incalci, Maurizio, Orlandi, Armando, Giraudo, Enrico, Sartore-Bianchi, Andrea, Siena, Salvatore, Pietrantonio, Filippo, Di Nicolantonio, Federica, and Bardelli, Alberto

Published
2017
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42. Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

Author

Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B., Nicolantonio, Federica Di, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, and Bardelli, Alberto

Subjects
Care and treatment, Physiological aspects, Development and progression, Genetic aspects, Research, Epidermal growth factor receptors -- Physiological aspects -- Genetic aspects -- Research, Colorectal cancer -- Development and progression -- Genetic aspects -- Care and treatment -- Research
Abstract

An improved understanding of the underlying molecular pathology of CRC has enabled tailored treatment regimens and helped optimize outcomes. CRC tissue is currently used to define the molecular status of [...], Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and clonal evolution. The molecular profile of CRC is routinely assessed in surgical or bioptic samples (1). Genotyping of CRC tissue has inherent limitations; a tissue sample represents a single snapshot in time, and it is subjected to spatial selection bias owing to tumor heterogeneity. Repeated tissue samples are difficult to obtain and cannot be used for dynamic monitoring of disease progression and response to therapy. We exploited circulating tumor DNA (ctDNA) to genotype colorectal tumors and track clonal evolution during treatment with the epidermal growth factor receptor (EGFR)-specific antibodies cetuximab or panitumumab. We identified alterations in ctDNA of patients with primary or acquired resistance to EGFR blockade in the following genes: KRAS, NRAS, MET, ERBB2, FLT3, EGFR and MAP2K1. Mutated KRAS clones, which emerge in blood during EGFR blockade, decline upon withdrawal of EGFR-specific antibodies, indicating that clonal evolution continues beyond clinical progression. Pharmacogenomic analysis of CRC cells that had acquired resistance to cetuximab reveals that upon antibody withdrawal KRAS clones decay, whereas the population regains drug sensitivity. ctDNA profiles of individuals who benefit from multiple challenges with anti-EGFR antibodies exhibit pulsatile levels of mutant KRAS. These results indicate that the CRC genome adapts dynamically to intermittent drug schedules and provide a molecular explanation for the efficacy of rechallenge therapies based on EGFR blockade.

Published
2015

43. Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer

Author

Durinikova, Erika, primary, Reilly, Nicole M., additional, Buzo, Kristi, additional, Mariella, Elisa, additional, Chilà, Rosaria, additional, Lorenzato, Annalisa, additional, Dias, João M. L., additional, Grasso, Gaia, additional, Pisati, Federica, additional, Lamba, Simona, additional, Corti, Giorgio, additional, Degasperi, Andrea, additional, Cancelliere, Carlotta, additional, Mauri, Gianluca, additional, Andrei, Pietro, additional, Linnebacher, Michael, additional, Marsoni, Silvia, additional, Siena, Salvatore, additional, Sartore-Bianchi, Andrea, additional, Nik-Zainal, Serena, additional, Di Nicolantonio, Federica, additional, Bardelli, Alberto, additional, and Arena, Sabrina, additional

Published
2022
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44. Abstract 1593: Genetic and pharmacological modulation of DNA mismatch repair promotes immune surveillance in murine colorectal cancer

Author

Amodio, Vito, primary, Germano, Giovanni, additional, Mussolin, Benedetta, additional, Lamba, Simona, additional, Chilà, Rosaria, additional, Rospo, Giuseppe, additional, Marchiò, Caterina, additional, Marsoni, Silvia, additional, Mauri, Gianluca, additional, Di Nicolantonio, Federica, additional, and Bardelli, Alberto, additional

Published
2022
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48. Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab

Author

Roock, Wendy De, Jonker, Derek J., Nicolantonio, Federica Di, Sartore-Bianchi, Andrea, Dongsheng Tu, Lamba, Simona, Siena, Salvatore, Arena, Sabrina, Frattini, Milo, Piessevaux, Hubert, Cutsem, Eric Van, O'Callaghan, Chris J., Khambata-Ford, Shirin, Zalcberg, John R., Simes, John, Karapetis, Christos S., Bardelli, Alberto, and Tejpar, Sabine

Subjects
Colorectal cancer -- Drug therapy, Colorectal cancer -- Genetic aspects, Colorectal cancer -- Patient outcomes, Gene mutations -- Analysis
Abstract

Pooled data sets from patients with chemotherapy-refractory colorectal cancer treated with cetuximab between 2001 and 2008 was used to study the association between KRAS condon 13 mutations and response and survival after treatment with cetuximab compared to those observed with other KRAS mutations. Cetuximab was found to be associated with longer overall and progression-free survival among patients with chemotherapy-refractory colorectal cancer with p.G13D-mutated tumors than with other KRAS-mutated tumors and suggested a need for further randomized trials.

Published
2010

49. CD4 T Cell–Dependent Rejection of Beta-2 Microglobulin Null Mismatch Repair–Deficient Tumors

Author

Germano, Giovanni, primary, Lu, Steve, additional, Rospo, Giuseppe, additional, Lamba, Simona, additional, Rousseau, Benoit, additional, Fanelli, Sonia, additional, Stenech, Denise, additional, Le, Dung T., additional, Hays, John, additional, Totaro, Maria Grazia, additional, Amodio, Vito, additional, Chilà, Rosaria, additional, Mondino, Anna, additional, Diaz, Luis A., additional, Di Nicolantonio, Federica, additional, and Bardelli, Alberto, additional

Published
2021
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