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2. Factors Associated With Coronary Angiography Performed Within 6 Months of Randomization to the Conservative Strategy in the ISCHEMIA Trial
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Pracoń, Radosław, Spertus, John A., Broderick, Samuel, Bangalore, Sripal, Rockhold, Frank W., Ruzyllo, Witold, Demchenko, Elena, Nageh, Thuraia, Grossman, Gabriel Blacher, Mavromatis, Kreton, Manjunath, Cholenahally N., Smanio, Paola E.P., Stone, Gregg W., Mancini, G.B. 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Arunima, Huda, Zohra, Wall, Matthew, Boan, Araceli, Lenges De Rosen, Veronica, Alam, Mahboob, Turner, Michael C., Hinton, Christine R, Mulhearn, Thomas J., Good, Arnold P., Archer, Beth A., Dionne, Julia S., Allardyce, Cheryl A., Sikora, Lindsey N., Czerniak, Jennifer H., Mull, Jennifer A., Ferguson, Elizabeth, Laube, Frances, Shammas, Nicolas W., Shammas, Gail A, Christensen, Lori, Park, Holly, Chilton, Robert, Hecht, Joan, Nguyen, Patricia K., Vo, Davis, Hirsch, James, Jezior, Matthew, Bindeman, Jody, Salkind, Sara, Espinosa, Dalisa, Desimone, Lori-Ann, Gordon, Paul C., Felix-Stern, Lina, Crain, Thomas, Gomes, Jassira, Gordon, Catherine, Stenberg, Robert, Mann, Aimee, McCreary, Theresa, Pedalino, Ronald P., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Wiesel, Joseph, Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Juang, George J., Gopaul, Candace, Hultberg, Karen, Huk, Tauqir, Hussain, Afshan, Al-Amoodi, Mohammed, Zambrano, Yesenia, Medina Rodriguez, Sarah, Milner, Trudie, Wohns, David, Mulder, Abbey, Van Oosterhout, Stacie, Lader, Ellis W., Meyer, Martha, Mumma, Michael, Clapp, Nancy L., Barrentine, Heather, Dharmarajan, Lekshmi, Jose, Jenne M., Cobos, Stanley E., Dwyer, Raven R., Espinosa, Dalisa, Quiles, Kirsten J., Manchery, Jenne, McGarvey Jr, Joseph F.X., McKinney, Vera, Schwarz, Linda, Downes, Thomas R., Kaczkowski, Scott M., Luckasen, Gary J., Jaskowiak, Adam J., Klitch, Joel, Cheong, Benjamin, Dees, Debra, Potluri, Srinivasa, Vasquez, Precilia, Mastouri, Ronald A., Breall, Jeffery A., Hannemann, Elise L., Revtyak, George E., Mae Foltz, Judy, Bazeley, Jonathan W., Li, Dayuan, DeRosa, Emily, Jorgenson, Beth, Riestenberg-Smith, Joyce, Giedd, Kenneth, Old, Wayne, Bariciano, Rebecca, Burt, Francis, Sokhon, Kozhaya, Waldron, Jessica, Mayon, Michelle, Gopal, Deepika, Valeti, Uma S., Ann Peichel, Gretchen, Kobashigawa, Jon, Starks, Brandy, Garcia, Lucilla, Thottam, Maria, Bhargava, Balram, Anand, Anjali, Chakanalil Govindan, Sajeev, Raj, Janitha, Gopalan Nair, Rajesh, Ravindran, Reshma, Rajalekshmi, VS, Nataraj, Nandita, Moorthy, Nagaraja, Nayak, Soundarya, Mylarappa, Mahevamma, Narayanappa, Suryaprakash, Pandit, Neeraj, Bajaj, Sheromani, Kumar Nath, Ranjit, Yadav, Vandana, Mishra, Girish, Dwivedi, S.K., Tewari, Roma, Narain, V.S., Mishra, Meenakshi, Chandra, Sharad, Patel, Shivali, Singh, Suman, Wander, Gurpreet S., Tandon, Rohit, Ralhan, Sarju, Kaur, Baljeet, Aslam, Naved, Gupta, Sonika, Goyal, Abhishek, Bhargava, Balram, Suvarna, Chandini, Karthikeyan, G., Ramakrishnan, S., Seth, Sandeep, Yadav, Rakesh, Singh, Sandeep, Roy, Ambuj, Parakh, Neeraj, Kumar Verma, Sunil, Narang, Rajiv, Mishra, Sundeep, Naik, Nitish, Sharma, Gautam, Kumar Choudhary, Shiv, Patel, Chetan, Gulati, Gurpreet, Sharma, Sanjeev, Bahl, V K, Mathew, Anoop, Mannekkattukudy Kurian, Binoy, Punnoose, Eapen, Avdhoot Gadkari, Milind, Rupesh Karwa, Sheetal, Gadage, Siddharth, Kolhe, Suvarna, Umesh Pillay, Tapan, Satheesh, 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A., Oliveira, Natalia S, Lima, Rodolfo G. S. D, Figueiredo, Estevao, Edilena Paulino Azevedo, Bruna, Ricardo Caramori, Paulo, Bizzaro Santos, Marco, Germann, Amanda, Gomes, Vitor, Homem, Rosa, Magedanz, Ellen, Tumelero, Rogerio, Laimer, Rosane, Tognon, Alexandre, Dall’Orto, Frederico, Mesquita, Claudio T., Santos, Roberta P, Colafranseschi, Alexandre S., Oliveira, Amarino C., Carvalho, Luiz A., Palazzo, Isabella C., Sousa, Andre S., Eustáquio Ribeiro da Silva, Expedito, Gabriel Melo de Barros e Silva, Pedro, Yumi Okada, Mariana, de Pádua Silva Baptista, Luciana, Paula Batista, Ana, Jamus Rodrigues, Marcelo, Nogueira Rabaça, Aline, Valério Coimbra de Resende, Marcos, Francisco Saraiva, Jose, Miranda Trama, Larissa, Silva, Talita, Thais de Souza Ormundo, Camila, Vicente, Carla, Costantini, Costantino, Pinheiro, Caroline, Komar, Daniele, Szwed, Hanna, Demkow, Marcin, Kepka, Cezary, Teresinska, Anna, Walesiak, Olga, Kryczka, Karolina, Malinowska, Katarzyna, Henzel, Jan, Solecki, Mateusz, Kaczmarska, Edyta, Mazurek, Tomasz, Maksym, Jakub, Wojtera, Karolina, Fojt, Anna, Szczerba, Ewa, Drozdz, Jaroslaw, Czarniak, Bartosz, Frach, Malgorzata, Szymczyk, Konrad, Niedzwiecka, Iwona, Sobczak, Sebastian, Ciurus, Tomasz, Jakubowski, Piotr, Misztal-Teodorczyk, Magdalena, Teodorczyk, Dawid, Swiderek, Marta, Fratczak, Aleksandra, Wojtala, Ewelina, Szkopiak, Marcin, Lebioda, Patrycja, Wlodarczyk, Michal, Plachcinska, Anna, Kusmierek, Jacek, Miller, Magdalena, Marciniak, Halina, Wojtczak-Soska, Karolina, Łuczak, Katarzyna, Tarchalski, Tomasz, Cichocka-Radwan, Anna, Szwed, Hanna, Karwowski, Jaroslaw, Anna Szulczyk, Grazyna, Witkowski, Adam, Kukuła, Krzysztof, Celińska-Spodar, Małgorzta, Zalewska, Joanna, Gajos, Grzegorz, Bury, Krzysztof, Pruszczyk, Piotr, Łabyk, Andrzej, Roik, Marek, Szramowska, Agnieszka, Zdończyk, Olga, Łoboz-Grudzień, Krystyna, Jaroch, Joanna, Sokalski, Leszek, Brzezińska, Barbara, Lesiak, Maciej, Łanocha, Magdalena, Reczuch, Krzysztof W., Kolodziej, Adam, Kalarus, Zbigniew, Swiatkowski, Andrzej, Szulik, Mariola, Musial, Wlodzimierz J., Marcinkiewicz-Siemion, Marta, Bockeria, Olga, Bockeria, Leo, Bockeria, Olga, Petrosyan, Karen, Kudzoeva, Zalina, Trifonova, Tatiana, Aripova, Nodira, Chernyavskiy, Alexander M., Naryshkin, Ivan A., Kretov, Evgeniy I., Kuleshova, Alena, Grazhdankin, Igor O., Malaev, Dastan, Bershtein, Leonid L., Sayganov, Sergey A., Subbotina, Irina, Kuzmina-Krutetskaya, Anastasia M., Gumerova, Victoria, Zbyshevskaya, Elizaveta V., Katamadze, Nana O., Nikolaeva, Olga B., Kozlov, Pavel S., Kozulin, Vikentiy Y., Lubinskaya, Ekaterina I., Luis Lopez-Sendon, Jose, Castro, Almudena, Lopez-Sendon, Jose, Fernández-Figares, Virginia, Castro, Almudena, Refoyo Salicio, Elena, Guzman, Gabriela, Galeote, Gabriel, Valbuena, Silvia, Peteiro, Jesús, Dolores Martínez-Ruíz, María, Pérez-Fernández, Ruth, Blanco-Calvo, Moisés, Cuenca-Castillo, José J, Alonso-Álvarez, Encarnación, Flores-Ríos, Xacobe, García-González, Paula, Prada-Delgado, Óscar, Barge-Caballero, Gonzalo, Ramon Gonzalez Juanatey, Jose, Seijas Amigo, Jose, Souto Bayarri, Miguel, Pubull Nuñez, Virginia, Ocaranza Sanchez, Raymundo, Cid Alvarez, Belen, Peña Gil, Carlos, Martinez Monzonis, Amparo, Sionis, Alessandro, Fernández Martínez, Ana, Vila Perales, Montserrat, Maria Padró, Josep, Serra Peñaranda, Antonio, García Picart, Joan, Ginel Iglesias, Antonino, Garcia-Moll Marimon, Xavier, Pons Lladó, Guillem, Carreras Costa, Francesc, Miro, Vicente, Igual, Begoña, Diez, Jose L, Calvillo, Pilar, Ortuño, F. Marin, Valdés Chávarri, M., Quintana Giner, M., Tello Montolliu, A., Romero Aniorte, A.I., Pinar Bermudez, E., Rivera Caravaca, JM., De La Morena, G., Gracida Blancas, Montserrat, Cañavate, Olga, Guerrero, Sonia, Riera, Silvia, Enrique Castillo Luena, Jose, Enrique Castillo Luena, Jose, Lasala, Maria, Fernandez-Aviles, Francisco, Lorenzo, Maria, Sobrino, Olga, Vazquez, Alexandra, Jiang, Lixin, Chen, Jiyan, Dong, Haojian, He, Peiyu, Xia, Chunli, Yang, Junqing, Zhong, Qi, Wu, Yongjian, Tian, Yanmeng, Li, Dongze, Ma, Yitong, Li, Xiaomei, Yang, Yining, Ma, Xiang, Yu, Zixiang, Zhao, Qian, Ji, Zheng, Li, Chunguang, Zhang, Lei, Zhao, Yu, Zhu, Bolin, Yang, Xinchun, Chen, Mulei, Chi, Hongjie, Wang, Yang, Zhang, Jing, Lin, Wenhua, Jing, Rui, Liu, Jingjing, Zeng, Hesong, Zhou, Qiang, Xu, Chang, Li, Zhuxi, Li, Junhua, Xiong, Luyang, Fu, Xin, Gao, Dan, Jiang, Dengke, Leng, Ran, Wang, Xutong, Yuan, Qianqian, Zhang, Lili, Yang, Bin, Bai, Ziliang, Li, Jianhua, Qi, Jie, Wang, Fei, Wang, Haitao, Yang, 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Louis, Thuaire, Christophe, Tachot, Emilie, Dutoiu, Téodora, Laure, Christophe, Vassaliere, Christel, Steg, Philippe Gabriel, Abergel, Helene, Juliard, Jean-Michel, Fuentes, Axelle, Slama, Michel S., Eliahou, Ludivine, Cedex, Clamart, El Mahmoud, Rami, Dubourg, Olivier, Michaud, Pierre, Nicollet, Eric, Hadjih, Sarah, Cedex, Corbeil-Essonnes, Goube, Pascal, Brito, Patricia, Barone-Rochette, Gilles, Barone-Rochette, Gilles, Furber, Alain, Cornet, Charles, Bière, Loïc, Rautureau, Jeremy, Juceviciene, Agne, Kalibataite-Rutkauskiene, Irma, Keinaite, Laura, Laucevicius, Aleksandras, Laukyte, Monika, Celutkiene, Jelena, Mikolaitiene, Gelmina, Smigelskaite, Akvile, Tamasauskiene, Ilona, Urboniene, Agne, Kedhi, Elvin, Klinieken, Isala, Timmer, Jorik, Bouwhuis, Ilse, Hermanides, Rik, Nijmeijer, Lia, Kaplan, Eliza, Riezebos, Robert K., Samadi, Pouneh, Schoep Jeannette, J. M., Dongen, Elise van, Janzen, Elisabeth M., Niehe, Sander R., Suryapranata, Harry, Ahoud, Sandra, Vugt, Stijn van, Ramos, Ruben, Santa Marta, Hospital de, Cacela, Duarte, Santana, Ana, Fiarresga, Antonio, Sousa, Lidia, Marques, Hugo, Patricio, Lino, Selas, Mafalda, Bernanrdes, Luis, Silva, Filipa, Rio, Pedro, Freixo, Cláudia, Carvalho, Ramiro, Ferreira, Rui, Silva, Tiago, Rodrigues, Ines, Modas, Pedro, Portugal, Guilherme, Fragata, Jose, Pinto, Fausto J., Cabrita, Inês Zimbarra, Menezes, Miguel Nobre, Rocha, Andreia, Lopes, Guilhermina Cantinho, Figueiras, Francisca Patuleia, Almeida, Ana Gomes, Coelho, Andreia, CanVas Silva, Pedro, Capinha, Marta, Nobre, Angelo, Caetano, Maria Inês, Francisco, Ana Rita, Silva, Susana, Ferreira, Nuno, de Gaia, Vila Nova, Lopes, Ricardo L., Diaz, Rafael, Guzman, Luis, Tinnirello, Veronica, Figal, Julio César, Nicolás Mungo, Matías, Buenos Aires, Ciudad Autonoma de, Méndiz, Oscar, Cortés, Claudia, Favaloro, Roberto René, Alvarez, Carlos, Garcia, Marina, Blanca, Bahia, Courtis, Javier, Godoy, Valeria, Zeballos, Gabriela, Schiavi, Lilia, Actis, Maria Victoria, Rubio, Mariano, Scaro, Graciela, White, Harvey Douglas, Alsweiler, Caroline, Devlin, Gerard Patrick, Low, Liz, Fisher, Raewyn, Scales, Jayne, Abercrombie, Kirsty, Stewart, Ralph Alan Huston, Howell, Leah, White, Harvey Douglas, Patten, Cathrine, Benatar, Jocelyne, Kedev, Sasko, Mitevska, Irena Peovska, Kostovska, Elizabeta Srbinovska, Pejkov, Hristo, Held, Claes, Held, Claes, Eggers, Kai, Frostfelt, Gunnar, Björklund, Christina, Johnston, Nina, Andreasson, Maria, Olsowka, Maciej, Essermark, Marie, Åkerblom, Axel, Soveri, Inga, Aspberg, Johannes, Persson, Liselotte, Beyar, Rafael, Sharir, Tali, Nikolsky, Eugenia, Sharir, Tali, Harel, Or, Elian, Dan, Kerner, Arthur, Bentzvi, Margalit, Massalha, Samia, Helmer, Ludmila, Kohsaka, Shun, Fukuda, Keiichi, Ueda, Ikuko, Kohsaka, Shun, Fujita, Jun, Yasuda, Satoshi, Furukawa, Akemi, Hirase, Kanae, Nagai, Toshiyuki, Otsuka, Fumiyuki, Nishimura, Shigeyuki, Nakano, Shintaro, de Werf, Frans Van, Goetschalckx, Kaatje, Goetschalckx, Kaatje, Robesyn, Valerie, de Werf, Frans Van, Claes, Kathleen, White, Harvey Douglas, Alsweiler, Caroline, Hung, Chung-Lieh, Yang, Yi-Hsuan, Yun, Chun-Ho, Hou, Charles Jia-Yin, Kuo, Jen-Yuan, Yeh, Hung-I, Hung, Ta-Chuan, Li, Jiun-Yi, Chien, Chen-Yen, Tsai, Cheng-Ting, Liu, Chun-Chieh, Yu, Fa-Chang, Lin, Yueh-Hung, Lan, Wei-Ren, Yen, Chih-Hsuan, Tsai, Jui-Peng, Sung, Kuo-Tzu, Ntsekhe, Mpiko, Pandie, Shaheen, Philander (Nee Talliard), Constance, Viljoen, Charle A, Mtana, Noloyiso, De Andrade, Marianne, Maggioni, Aldo P., Moccetti, Tiziano, Anesini, Adriana, Rossi, M.Grazia, Maspoli, Simona, Mombelli, Manuela, Abdelhamid, Magdy, Talaat, Ahmed, Adel, Ahmed, Kamal, Ahmed, Mahrous, Hossam, Kaffas, Sameh El, Fishawy, Hussien El, Pop, Calin, Claudia, Matei, Popescu, Bogdan A., Ginghina, Carmen, Rosca, Monica, Deleanu, Dan, Beladan, Carmen C., Iliescu, Vlad A., Al-Mallah, Mouaz H., Zahrani, Sarah, Aljzeeri, Ahmed, Najm, Hani, Alghamdi, Ali, Mogrovejo Ramos, Walter Enrique, Monsalve Davila, Marco Antonio, White, Harvey Douglas, Alsweiler, Caroline, Kuanprasert, Srun, Mai, Chiang, Prommintikul, Arintaya, Nawarawong, Weerachai, Khwakhong, Supatchara, Woragidpoonpol, Surin, Chaiyasri, Anong, Tepsuwan, Thitipong, Mekara, Warangkana, Taksaudom, Noppon, Kulthawong, Supap, Rimsukcharoenchai, Chataroon, Amaritakomol, Anong, Euathrongchit, Juntima, Wannasopha, Yutthaphan, Yamwong, Sukit, Panpunuan, Pachara, Sritara, Piyamitr, Aramcharoen, Suthara, Meemuk, Krissada, White, Harvey Douglas, Alsweiler, Caroline, Khairuddin, Ahmad, Mokhtar, Noor Syamira, Hadi, Hafidz Abd, Basri, Nor Asiah, Yahaya, Shaiful Azmi, Yusnida, Irni, Hashim, Humayrah, Harrington, Robert, Williams, David, Alexander, Karen P., Berger, Jeffrey, Harrington, Robert, Mark, Daniel, O’Brien, Sean M., Rosenberg, Yves, Shaw, Leslee J., Ballantyne, Christie, Berman, Daniel, Beyar, Rafael, Bhargava, Balram, Buller, Chris, (Tony) Carvalho*, Antonio, Chaitman, Bernard R., Diaz, Rafael, Doerr, Rolf, Dzavik, Vladimir, Goodman, Shaun, Gosselin, Gilbert, Hachamovitch, Rory, Hamm, Christian, Held, Claes, Helm, Malte, Huber, Kurt, Jiang, Lixin, Keltai, Matyas, Kohsaka, Shun, Lang, Irene, Lopes, Renato, Lopez-Sendon, Jose, Maggioni, Aldo, Bairey Merz, C. Noel, Min, James, Peterson, Eric, Picard, Michael H., Selvanayagam, Joseph, Senior, Roxy, Sharir, Tali, Steg, Gabriel, Szwed, Hanna, de Werf, Frans Van, Weintraub, William, White, Harvey, Williams, David, Ballantyne, Christie, Calfas*, Karen, Chaitman, Bernard R., Champagne, Mary Ann, Davidson, Michael, Fleg, Jerome, McCullough, Peter A., Stone, Peter, Menasche, Philippe, Davidson*, Michael, Fremes, Stephen, Guyton, Robert, Mack, Michael, Mohr, Fred, Rao, Anupama, Sabik, Joe, Shapira, Oz, Taggart, David, Tatoulis, James, Williams, David, Blankenship, Jim, Brener, Sorin, Buller, Chris, Colombo, Antonio, Bruyne, Bernard de, Généreux, Philippe, Harrington, Robert, Kereiakes, Dean, Lefevre, Thierry, Moses, Jeffrey, Chaitman, Bernard R., Alexander, Karen P., Mahaffey, Ken, White, Harvey, Chaitman, Bernard R., Cruz-Flores, Salvador, Danchin, Nicholas, Feen, Eli, Garcia, Mario J., Hauptman, Paul, Laddu, Abhay A., Passamani, Eugene, Pina, Ileana L., Simoons, Maarten, Skali, Hicham, Thygesen, Kristian, Waters, David, Alexander, Karen P., Endsley, Patricia, Esposito, Gerard, Kanters, Jeffrey, Pownall, John, Stournaras, Dimitrios, Shaw, Leslee J., Berman, Daniel, Friedrich, Matthias, Hachamovitch, Rory, Kwong, Raymond, Min, James, Oliver, Dana, Picard, Michael H., Harrell, Frank, Blume, Jeffrey, Lee, Kerry, O’Brien, Sean M., Berger, Jeffrey, Held, Claes, Kullo, Iftikhar, McManus, Bruce, Newby, Kristin, Mark, Daniel, Cohen, David, Weintraub, William, Merz, C. Noel Bairey, Bugiardini, Raffaele, Celutkiene, Jelena, Escobedo, Jorge, Hoye, Angela, Lyubarova, Radmila, Mattina, Deirdre, Peteiro, Jesus, Alexander, Karen P., Berger, Jeffrey, Harrington, Robert, O’Brien, Sean M., Rosenberg, Yves, Mark, Daniel, Mark, Daniel, Shaw, Leslee J., Berman, Dan, Chaitman, Bernard R., Fleg, Jerome, Kwong, Raymond, Picard, Michael H., Senior, Roxy, Min, James, Leipsic, Jonathan, Ali, Ziad, Williams, David, Fleg, Jerome, Berger, Jeffrey, Chaitman, Bernard R., Alexander, Karen P., Alexander, Karen P., Fleg, Jerome, Mathew, Roy, O’Brien, Sean M., Sidhu, Mandeep, Friedman, Lawrence, Anderson, Jeffrey, Berg, Jessica, DeMets, David, Gibson, C. Michael, Lamas, Gervasio, Deming, Nicole, Himmelfarb, Jonathan, Ouyang, Pamela, Woodard, Pamela, Harrell, Frank, Nwosu, Samuel, Rosenberg, Yves, Fleg, Jerome, Kirby, Ruth, Jeffries, Neal, Berger, Jeffrey, Sidhu, Mandeep, Denaro*, Jean E., Mavromichalis, Stephanie, Chan, Kevin, Cobb, Gia, Contreras, Aira, Cukali, Diana, Ferket, Stephanie, Gabriel, Andre, Hansen, Antonietta, Roberts, Arline, Chang, Michelle, Islam, Sharder, Wayser, Graceanne, Yakubov, Solomon, Yee, Michelle, Callison, Caroline, Hogan, Isabelle, Qelaj, Albertina, Pirro, Charlotte, Loo, Kerrie Van, Wisniewski, Brianna, Gilsenan, Margaret, Lang, Bevin, Mohamed, Samaa, Esquenazi-Karonika, Shari, Mathews, Patenne, Naumova, Anna, Lyo, Jihyun, Setang, Vincent, Xavier, Mark, O’Brien, Sean M., Alexander, Karen P., Mark, Daniel B., Anstrom, Kevin, Baloch, Khaula, Blount, Janet, Cowper, Patricia, Davidson-Ray, Linda, Drew, Laura, Harding, Tina, Knight, J David, Liu, Diane Minshall, O’Neal, Betsy, Redick, Thomas, Jones, Philip, Nugent, Karen, Wang, Grace Jingyan, Shaw, Leslee J., Phillips, Lawrence, Goyal, Abhinav, Hetrick, Holly, Oliver, Dana, Berman, Daniel, Hayes, Sean W., Friedman, John D., Gerlach, R. James, Hyun, Mark, Miranda-Peats, Romalisa, Slomka, Piotr, Thomson, Louise, Kwong, Raymond Y., Friedrich, Matthias, Mongeon, Francois Pierre, Michael, Steven, Picard, Michael H., Hung, Judy, Scherrer-Crosbie, Marielle, Zeng, Xin, Chaitman, Bernard R., Eckstein, Jane, Guruge, Bandula, Streif, Mary, Ali, Ziad, Genereux, Philippe, Alfonso, Maria A., Corral, Maria P., Garcia, Javier J., Horst, Jennifer, Jankovic, Ivana, Konigstein, Maayan, Lustre, Mitchel B., Peralta, Yolayfi, Sanchez, Raquel, Min, James, Arsanjani, Reza, Budoff, Matthew, Elmore, Kimberly, Gomez, Millie, Hague, Cameron, Hindoyan, Niree, Leipsic, Jonathan, Nakanishi, Rine, Srichai-Parsia, M. Barbara, Yeoh, Eunice, Youn, Tricia, Maggioni, Aldo P., Bianchini, Francesca, Ceseri, Martina, Lorimer, Andrea, Magnoni, Marco, Orso, Francesco, Sarti, Laura, Tricoli, Martinia, Carvalho, Antonio, Lopes, Renato, Barbosa, Lilian Mazza, Duarte, Tauane Bello, Soares, Tamara Colaiácovo, Aveiro Morata, Julia de, Carvalho, Pedro, Carvalho Maffei, Natalia de, Egydio, Flávia, Kawakami, Anelise, Oliveira, Janaina, Piloto, Elissa Restelli, Pozzibon, Jaqueline, Goodman, Shaun, Camara, Diane, Mowafy, Neamat, Spindler, Caroline, Jiang, Lixin, Dai, Hao, Feng, Fang, Li, Jia, Li, Li, Liu, Jiamin, Xie, Qiulan, Zhang, Haibo, Zhang, Jianxin, Zhang, Lihua, Zhang, Liping, Zhang, Ning, Zhong, Hui, Diaz, Rafael, Escobar, Claudia, Martin, Maria Eugenia, Pascual, Andrea, Lopez-Sendon, José, Moraga, Paloma, Hernandez, Victoria, Castro, Almudena, Posada, Maria, Fernandez, Sara, Villanueva, José Luis Narro, Selgas, Rafael, Steg, Gabriel, Abergel, Helene, Juliard, Jean Michel, White, Harvey, Alsweiler, Caroline, de Werf, Frans Van, Claes, Kathleen, Goetschalckx, Kaatje, Luyten, Ann, Robesyn, Valerie, Selvanayagam, Joseph B., Murphy, Deirdre, Ahmed, Asker, Bhatt, Richa, Chadha, Nitika, Kumar, Vijay, Lubna, Sadath, Naik, Pushpa, Pandey, Shruti, Ramasamy, Karthik, Saleem, Mohammed, Sharma, Pratiksha, and Siddaram, Hemalata
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- 2024
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- View/download PDF
3. Environment and cardiovascular health: causes, consequences and opportunities in prevention and treatment
- Author
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Bañeras, Jordi, Iglesies-Grau, Josep, Téllez-Plaza, María, Arrarte, Vicente, Báez-Ferrer, Néstor, Benito, Begoña, Campuzano Ruiz, Raquel, Cecconi, Alberto, Domínguez-Rodríguez, Alberto, Rodríguez-Sinovas, Antonio, Ujueta, Francisco, Vozzi, Carlos, Lamas, Gervasio A., and Navas-Acién, Ana
- Published
- 2022
- Full Text
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4. Medioambiente y salud cardiovascular: causas, consecuencias y oportunidades en prevención y tratamiento
- Author
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Bañeras, Jordi, Iglesies-Grau, Josep, Téllez-Plaza, María, Arrarte, Vicente, Báez-Ferrer, Néstor, Benito, Begoña, Campuzano Ruiz, Raquel, Cecconi, Alberto, Domínguez-Rodríguez, Alberto, Rodríguez-Sinovas, Antonio, Ujueta, Francisco, Vozzi, Carlos, Lamas, Gervasio A., and Navas-Acién, Ana
- Published
- 2022
- Full Text
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5. The trial to assess chelation therapy 2 (TACT2): Rationale and design
- Author
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Lamas, Gervasio A., Anstrom, Kevin J., Navas-Acien, Ana, Boineau, Robin, Kim, Hwasoon, Rosenberg, Yves, Stylianou, Mario, Jones, Teresa L.Z., Joubert, Bonnie R., Santella, Regina M., Escolar, Esteban, Aude, Y. Wady, Fonseca, Vivian, Elliott, Thomas, Lewis, Eldrin F., Farkouh, Michael E., Nathan, David M., Mon, Ana C., Gosnell, Leigh, Newman, Jonathan D., and Mark, Daniel B.
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- 2022
- Full Text
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6. Edetate Disodium–Based Chelation for Patients With a Previous Myocardial Infarction and Diabetes: TACT2 Randomized Clinical Trial.
- Author
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Lamas, Gervasio A., Anstrom, Kevin J., Navas-Acien, Ana, Boineau, Robin, Nemeth, Hayley, Huang, Zhen, Wen, Jun, Rosenberg, Yves, Stylianou, Mario, Jones, Teresa L. Z., Joubert, Bonnie R., Yu, Qilu, Santella, Regina M., Mon, Ana C., Ujueta, Francisco, Escolar, Esteban, Nathan, David M., Fonseca, Vivian A., Aude, Y. Wady, and Ehrman, Jonathan K.
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MAJOR adverse cardiovascular events , *MYOCARDIAL infarction , *CORONARY artery disease , *MINERAL supplements , *CHELATION therapy - Abstract
Key Points: Question: Does therapy with edetate disodium (EDTA)–based chelation reduce major adverse cardiovascular events compared with placebo infusions among patients with diabetes and prior myocardial infarction (MI)? Findings: EDTA-based chelation did not reduce major adverse cardiovascular events compared with placebo infusion, with a hazard ratio of 0.93 (95% CI, 0.76-1.16; P =.53). Chelation infusions did reduce the median blood lead levels from 9.0 μg/L at baseline to 3.5 μg/L at infusion 40 (P <.001). Meaning: Among patients with diabetes and prior MI, EDTA-based chelation decreased median blood lead levels by 61% from baseline but did not reduce major adverse cardiovascular events. Importance: In 2013, the Trial to Assess Chelation Therapy (TACT) reported that edetate disodium (EDTA)–based chelation significantly reduced cardiovascular disease (CVD) events by 18% in 1708 patients with a prior myocardial infarction (MI). Objective: To replicate the finding of TACT in individuals with diabetes and previous MI. Design, Setting, and Participants: A 2 × 2 factorial, double-masked, placebo-controlled, multicenter trial at 88 sites in the US and Canada, involving participants who were 50 years or older, had diabetes, and had experienced an MI at least 6 weeks before recruitment compared the effect of EDTA-based chelation vs placebo infusions on CVD events and compared the effect of high doses of oral multivitamins and minerals with oral placebo. This article reports on the chelation vs placebo infusion comparisons. Interventions: Eligible participants were randomly assigned to 40 weekly infusions of an EDTA-based chelation solution or matching placebo and to twice daily oral, high-dose multivitamin and mineral supplements or matching placebo for 60 months. This article addresses the chelation study. Main Outcomes and Measures: The primary end point was the composite of all-cause mortality, MI, stroke, coronary revascularization, or hospitalization for unstable angina. Median follow-up was 48 months. Primary comparisons were made from patients who received at least 1 assigned infusion. Results: Of the 959 participants (median age, 67 years [IQR, 60-72 years]; 27% females; 78% White, 10% Black, and 20% Hispanic), 483 received at least 1 chelation infusion and 476 at least 1 placebo infusion. A primary end point event occurred in 172 participants (35.6%) in the chelation group and in 170 (35.7%) in the placebo group (adjusted hazard ratio [HR], 0.93; 95% CI, 0.76-1.16; P =.53). The 5-year primary event cumulative incidence rates were 45.8% for the chelation group and 46.5% for the placebo group. CV death, MI, or stroke events occurred in 89 participants (18.4%) in the chelation group and in 94 (19.7%) in the placebo group (adjusted HR, 0.89; 95% CI, 0.66-1.19). Death from any cause occurred in 84 participants (17.4%) in the chelation group and in 84 (17.6%) in the placebo group (adjusted HR, 0.96; 95% CI, 0.71-1.30). Chelation reduced median blood lead levels from 9.03 μg/L at baseline to 3.46 μg/L at infusion 40 (P <.001). Corresponding levels in the placebo group were 9.3 μg/L and 8.7 μg/L, respectively. Conclusions and Relevance: Despite effectively reducing blood lead levels, EDTA chelation was not effective in reducing cardiovascular events in stable patients with coronary artery disease who have diabetes and a history of MI. Trial Registration: ClinicalTrials.gov Identifier: NCT02733185 This randomized clinical trial assesses whether edetate disodium–based chelation infusions decrease cardiovascular disease events compared with placebo among patients with diabetes and prior myocardial infarction. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Differential Outcomes With Edetate Disodium-Based Treatment Among Stable Post Anterior vs. Non-Anterior Myocardial Infarction Patients
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Lewis, Eldrin F., Ujueta, Francisco, Lamas, Gervasio A., Roberts, Rhonda S., Mark, Daniel B., Nahin, Richard L., Goertz, Christine, Stylianou, Mario, and Lee, Kerry L.
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- 2020
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8. Possible differential benefits of edetate disodium in post-myocardial infarction patients with diabetes treated with different hypoglycemic strategies in the Trial to Assess Chelation Therapy (TACT)
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Escolar, Esteban, Ujueta, Francisco, Kim, Hwasoon, Mark, Daniel B., Boineau, Robin, Nahin, Richard L., Goertz, Christine, Lee, Kerry L., Anstrom, Kevin J., and Lamas, Gervasio A.
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- 2020
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9. Low-Level Cadmium Exposure and Atherosclerosis
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Diaz, Denisse, Ujueta, Francisco, Mansur, Gisell, Lamas, Gervasio A., Navas-Acien, Ana, and Arenas, Ivan A.
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- 2021
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10. The effect of EDTA-based chelation on patients with diabetes and peripheral artery disease in the Trial to Assess Chelation Therapy (TACT)
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Ujueta, Francisco, Arenas, Ivan A., Escolar, Esteban, Diaz, Denisse, Boineau, Robin, Mark, Daniel B., Golden, Patrick, Lindblad, Lauren, Kim, Hwasoon, Lee, Kerry L., and Lamas, Gervasio A.
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- 2019
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11. A Personal Account of the Trials to Assess Chelation Therapy--The End of the Beginning?
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Lamas, Gervasio A.
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United States. National Institutes of Health ,United States. National Heart, Lung and Blood Institute ,Clinical trials ,EDTA ,Health - Abstract
Introduction To the reader: This is meant to be a scientific article but written in a narrative style for the Townsend Letter to improve its readability and decrease boredom. I [...]
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- 2020
12. Effect of high-dose oral multivitamins and minerals in participants not treated with statins in the randomized Trial to Assess Chelation Therapy (TACT)
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Issa, Omar M., Roberts, Rhonda, Mark, Daniel B., Boineau, Robin, Goertz, Christine, Rosenberg, Yves, Lewis, Eldrin F., Guarneri, Erminia, Drisko, Jeanne, Magaziner, Allan, Lee, Kerry L., and Lamas, Gervasio A.
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- 2018
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13. Response to, "Atrial fibrillation and quality of life"
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Fleischmann, Kirsten E, Lamas, Gervasio A, Mangione, Carol M, and Goldman, Lee
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Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology - Published
- 2009
14. Atrial fibrillation and quality of life Response
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Fleischmann, Kirsten E, Lamas, Gervasio A, Mangione, Carol M, and Goldman, Lee
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Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services - Published
- 2009
15. Atrial fibrillation and quality of life after pacemaker implantation for sick sinus syndrome: Data from the Mode Selection Trial (MOST)
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Fleischmann, Kirsten E, Orav, E John, Lamas, Gervasio A, Mangione, Carol M, Schron, Eleanor B, Lee, Kerry L, Goldman, Lee, and investigators, for the MOST
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Cardiovascular ,Heart Disease ,Clinical Trials and Supportive Activities ,Aged ,Aged ,80 and over ,Atrial Fibrillation ,Cohort Studies ,Cross-Over Studies ,Female ,Follow-Up Studies ,Humans ,Male ,Middle Aged ,Multivariate Analysis ,Outcome Assessment ,Health Care ,Pacemaker ,Artificial ,Prosthesis Design ,Quality of Life ,Randomized Controlled Trials as Topic ,Sick Sinus Syndrome ,MOST investigators ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundIn the Mode Selection Trial (MOST) of 2,010 patients with sinus node dysfunction, dual-chamber-paced patients had less atrial fibrillation (AF) and heart failure and had slightly improved health-related quality of life (QOL) compared with rate modulated right ventricular-paced patients. Our objective was to assess the impact of AF on QOL within MOST.MethodsWe analyzed serial QOL measures (Short Form-36, Specific Activity Scale, time trade-off) in 3 groups: (1) those without AF; (2) those with paroxysmal AF (PAF), but not chronic AF (CAF); and (3) those with CAF. We carried forward the last known QOL before crossover for all subsequent time points in patients randomized to rate modulated right ventricular pacing who crossed over to dual-chamber pacing for severe pacemaker syndrome.ResultsThree hundred seventeen patients (15.8%) had AF in the year after implantation, 206 patients within 3 months (191 PAF, 15 CAF), and another 159 (124 PAF, 35 CAF) between 3 and 12 months. There were no significant differences among groups in individual Short Form-36 subscales or time trade-off scores at 12 months as compared with baseline or 3 months. Cardiovascular health status was better at 12 months as compared with baseline or 3 months in those without AF.ConclusionsAtrial fibrillation after pacemaker implantation in elderly patients with sick sinus syndrome was not a major determinant of QOL. However, there was a trend toward better cardiovascular functional status in patients without AF.
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- 2009
16. Enhanced vasculotoxic metal excretion in post-myocardial infarction patients following a single edetate disodium-based infusion
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Arenas, Ivan A., Navas-Acien, Ana, Ergui, Ian, and Lamas, Gervasio A.
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- 2017
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17. Pacemaker implantation and quality of life in the Mode Selection Trial (MOST)
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Fleischmann, Kirsten E, Orav, E John, Lamas, Gervasio A, Mangione, Carol M, Schron, Eleanor, Lee, Kerry L, and Goldman, Lee
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Biomedical and Clinical Sciences ,Clinical Sciences ,Aging ,Cardiovascular ,Clinical Research ,Aged ,Cardiac Pacing ,Artificial ,Equipment Design ,Female ,Humans ,Longitudinal Studies ,Male ,Pacemaker ,Artificial ,Quality of Life ,Randomized Controlled Trials as Topic ,Sick Sinus Syndrome ,Treatment Outcome ,pacemakers ,pacing ,sinoatrial node ,arrhythmia ,Biomedical Engineering ,Cardiorespiratory Medicine and Haematology ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundDual-chamber pacemakers restore AV synchrony compared with ventricular pacemakers, but the effects on health-related quality of life (QOL) are uncertain.ObjectivesThe purpose of this study was to assess the effect of pacemaker implantation, clinical factors, and pacing mode on QOL.MethodsThe Mode Selection Trial (MOST) randomized 2,010 patients with sinus node dysfunction to rate-modulated right ventricular (VVIR) or dual-chamber (DDDR) pacing. A longitudinal analysis of serial QOL measures (Short Form-36 [SF-36], Specific Activity Scale, and time trade-off utility) was performed. In patients who crossed over from VVIR to DDDR because of severe pacemaker syndrome, the last known QOL prior to crossover was carried forward.ResultsPacemaker implantation resulted in substantial improvement in almost all QOL measures. Subjects 75 years or older experienced significantly less improvement in functional status and physical component summary scores than did younger subjects. In longitudinal analyses of the effect of pacing mode on QOL, significant improvement in three SF-36 subscales was observed with DDDR pacing compared with VVIR pacing: role physical [62.8 points (95% confidence interval [CI] 60.2, 65.5) vs 56.4 (95% CI 53.7, 59.1)], role emotional [85.0 (95% CI 82.9, 87.0) vs 81.9 (95% CI 79.9, 84.0)], and vitality [51.8 (95% CI 50.3, 53.3) vs 49.3 (95% CI 47.8, 50.7)], but not in other SF-36 subscales, the Specific Activity Scale, or utilities. The gains in QOL were larger than the declines associated with 1 year of aging but smaller than those associated with heart failure.ConclusionPacemaker implantation improved health-related QOL. The mode selected was associated with much smaller, but significant, improvements in several domains, particularly role physical function.
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- 2006
18. Health values before and after pacemaker implantation
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Lopez-Jimenez, Francisco, Goldman, Lee, Orav, E John, Ellenbogen, Kenneth, Stambler, Bruce, Marinchak, Roger, Wilkoff, Bruce L, Mangione, Carol M, Yoon, Catherine, Vitale, Kimberly, and Lamas, Gervasio A
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Biomedical and Clinical Sciences ,Clinical Sciences ,Clinical Research ,Good Health and Well Being ,Aged ,Costs and Cost Analysis ,Female ,Health Status ,Humans ,Male ,Pacemaker ,Artificial ,Prospective Studies ,Quality of Life ,Quality-Adjusted Life Years ,Single-Blind Method ,Cardiorespiratory Medicine and Haematology ,Public Health and Health Services ,Cardiovascular System & Hematology ,Cardiovascular medicine and haematology - Abstract
BackgroundHealth value or utility is the abstracted magnitude of a person's preference for quality and quantity of life. It reflects how much lifetime with the patient's current health condition a patient is willing to exchange for a life in excellent health. Health values are used in cost-effectiveness analysis as a means of calculating quality-adjusted years of life.ObjectiveThis study assessed the health values of elderly patients before and after pacemaker implantation.MethodsWe prospectively examined 398 patients from the Pacemaker Selection in the Elderly study, in which patients were randomized to either VVIR or DDDR mode. Health values were estimated with the time tradeoff method before implantation and at 3, 9, and 18 months after implantation.ResultsThe mean age of patients was 76 +/- 6 years; 234 patients (59%) were male. At baseline, patients were, on average, willing to exchange 5 years of current health for approximately 4 years in perfect health (value 0.76 +/- 0.06). There was no difference in baseline health values with implant diagnosis (sinus node dysfunction n = 172, 0.72, atrioventricular block n = 227, 0.75, other diagnoses n = 39, 0.78, P = not significant). The overall improvement in health values at 3 months after pacemaker implantation was 0.165 +/- 0.4 (P =.0001). The improvement in health values was independent of pacing mode (P =.6). The time tradeoff score was modestly correlated with other measurements of health-related quality of life. The change in time tradeoff score with time was not influenced by demographic characteristics such as age and sex, diagnoses, pacing mode, employment status, or history of angina. Patients with a lower functional class at enrollment (III or IV on the Specific Activity Scale) demonstrated an absolute improvement of 23% in their health values, whereas patients in class I or II improved only by 12%, (P =.03).ConclusionsPermanent pacemaker implantation for standard indications improves health values and descriptive health status measures. The values reported here may be used as a means of calculating the cost-effectiveness of different pacing modalities.
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- 2002
19. Outcome and cost-effectiveness of cardiopulmonary resuscitation after in-hospital cardiac arrest in octogenarians.
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Paniagua, David, Lopez-Jimenez, Francisco, Londoño, Juan C, Mangione, Carol M, Fleischmann, Kirsten, and Lamas, Gervasio A
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Humans ,Heart Arrest ,Treatment Outcome ,Cardiopulmonary Resuscitation ,Hospitalization ,Survival Rate ,Retrospective Studies ,Cohort Studies ,Age Factors ,Quality-Adjusted Life Years ,Aged ,Aged ,80 and over ,Cost-Benefit Analysis ,Health Care Costs ,Female ,Male ,cardiac arrest ,cardiopulmonary resuscitation ,cost-effectiveness ,octogenarians ,geriatrics ,Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology - Abstract
Octogenarians are the fastest growing segment of the population and little is known about the results of cardiopulmonary resuscitation (CPR) after in-hospital cardiac arrest in this population.We sought to investigate the clinical benefit and cost-effectiveness of CPR after in-hospital cardiac arrest in octogenarians.Years of life saved.Effectiveness data were obtained from a review of 91,372 hospital discharges from January 1st, 1993 until June 30th, 1996. Cardiac arrest was reported in 956 patients. The study group consisted of 474 patients > or = 80 years old. CPR costs included equipment and training, physician and nursing time and medications. Post-CPR expenses included in-hospital true cost, repeat hospitalizations, physician office visits, nursing home, rehabilitation, and chronic care hospital costs. Life expectancy of the patients who were still alive at the end of the study was estimated from census data. A utility of 0.8 was used to calculate quality-adjusted-life years saved (QALYS). We used a societal perspective for analysis.The study population was 86 +/- 4.8 years old (range 80-103), and 42% were male. Fifty-four patients (11%) were discharged alive, 35 to a chronic care facility and 19 to their home. Assuming that a cardiac arrest without CPR has 100% mortality, 12 octogenarians required treatment with CPR in order to save one life to hospital discharge. Similarly, 29 octogenarian patients with cardiac arrest have to be treated with CPR to net one long-term survivor (mean survival 21 months, with a range from 9 to 48 months). The cost-effectiveness ratio, after estimating the life expectancy of octogenarian survivors, was USD 50,412 per year of life saved, and USD 63,015 per QALYS. However, a utility of 0.5 yielded a cost of USD 100,825 per QALYS.In comparison with other life-saving strategies, CPR in octogenarians is effective. The favorable cost-effectiveness ratio is highly dependent on the patients' preference for quality rather than quantity of life, as expressed by the utility assumptions.
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- 2002
20. Outcomes, Trends, and Healthcare Disparities in Patients Hospitalized with Chronic Limb Threatening Ischemia
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Torres, Christian, primary, Ujueta, Francisco, additional, Rogers, Everett, additional, Ghazzal, Amre, additional, Santos, Radleigh, additional, Koelbl, Christian, additional, Escolar, Esteban, additional, Lamas, Gervasio A., additional, Parikh, Sahil A, additional, and Beohar, Nirat, additional
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- 2023
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21. Simplified prediction of postoperative cardiac surgery outcomes with a novel score: R2CHADS2
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Peguero, Julio G., Lo Presti, Saberio, Issa, Omar, Podesta, Carlos, Parise, Helen, Layka, Ayman, Brenes, Juan C., Lamelas, Joseph, and Lamas, Gervasio A.
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- 2016
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22. Effect of Spinal Manipulation of Upper Cervical Vertebrae on Blood Pressure: Results of a Pilot Sham-Controlled Trial
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Goertz, Christine M., Salsbury, Stacie A., Vining, Robert D., Long, Cynthia R., Pohlman, Katherine A., Weeks, William B., and Lamas, Gervasio A.
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- 2016
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23. Age‐Related Differences in Management of Heart Disease: A Study of Cardiac Medication Use in an Older Cohort
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Ganz, David A, Lamas, Gervasio A, Orav, E John, Goldman, Lee, Gutierrez, Peter R, and Mangione, Carol M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Health Sciences ,Aging ,Heart Disease - Coronary Heart Disease ,Clinical Research ,Heart Disease ,Cardiovascular ,2.4 Surveillance and distribution ,Aetiology ,Aged ,Aged ,80 and over ,Atrial Fibrillation ,Cardiovascular Agents ,Combined Modality Therapy ,Comorbidity ,Diabetes Mellitus ,Drug Therapy ,Combination ,Drug Utilization ,Female ,Frail Elderly ,Humans ,Male ,Myocardial Infarction ,Pacemaker ,Artificial ,Retrospective Studies ,Single-Blind Method ,Ventricular Dysfunction ,Left ,variation in care ,age ,cardiovascular disease treatment ,Medical and Health Sciences ,Geriatrics ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
BackgroundPrevious studies have suggested suboptimal use of cardiac medications for secondary prevention after myocardial infarction (MI) and atrial fibrillation (AF), especially among older people.ObjectiveTo determine whether patients older than 75 years are less likely than those aged 65 to 74 to be prescribed medications with evidence-based indications, including angiotensin-converting enzyme (ACE) inhibitors for left ventricular dysfunction (LVD) and/or diabetes mellitus (DM), aspirin and/or beta-blockers for those with a history of MI, and warfarin for chronic AF.DesignA retrospective cohort study.SettingTwenty-nine hospitals, predominantly tertiary-care institutions.ParticipantsA total of 407 patients randomized to ventricular or dual-chamber pacing from February 26, 1993, to September 30, 1994, in the Pacemaker Selection in the Elderly (PASE) trial.MeasurementsA review of the patient's medical history and a physical exam at study enrollment, three follow-up timepoints, and a study closeout.ResultsPatients older than 75 years with LVD and/or DM were less likely to be prescribed ACE inhibitors (OR = .56 (0.31-1.00)); patients older than 75 with a history of MI were less likely to be taking aspirin (OR = .43 (0.19-.95)), and patients older than 75 with AF were less likely to be prescribed warfarin (OR = .18 (0.05-.61)). Patients older than 75 years of age with any or all of the conditions studied were less likely to be prescribed indicated medications than those ages 65 to 74 (OR = .35 (0.18-.70)), after controlling for between-group differences in comorbidity, gender, and number of noncardiac medications.ConclusionOlder age is a significant independent negative correlate of evidence-based cardiac medication use in this cohort. Causes for this finding need to be explored.
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- 1999
24. Quality of Life and Clinical Outcomes in Elderly Patients Treated with Ventricular Pacing as Compared with Dual-Chamber Pacing
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Lamas, Gervasio A, Orav, E John, Stambler, Bruce S, Ellenbogen, Kenneth A, Sgarbossa, Elena B, Huang, Shoei K Stephen, Marinchak, Roger A, Estes, NA Mark, Mitchell, Gary F, Lieberman, Eric H, Mangione, Carol M, Goldman, Lee, Griffin, John J, Maloney, James D, Rizo-Patrón, Carlos, Venditti, Ferdinand J, and Wilkoff, Bruce L
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Heart Disease ,Neurosciences ,Clinical Research ,Cardiovascular ,Aging ,Bioengineering ,Clinical Trials and Supportive Activities ,Assistive Technology ,Evaluation of treatments and therapeutic interventions ,6.3 Medical devices ,Good Health and Well Being ,Aged ,Aged ,80 and over ,Bradycardia ,Cardiac Pacing ,Artificial ,Equipment Design ,Female ,Heart Block ,Humans ,Male ,Pacemaker ,Artificial ,Quality of Life ,Single-Blind Method ,Survival Analysis ,Treatment Outcome ,Medical and Health Sciences ,General & Internal Medicine - Abstract
BackgroundStandard clinical practice permits the use of either single-chamber ventricular pacemakers or dual-chamber pacemakers for most patients who require cardiac pacing. Ventricular pacemakers are less expensive, but dual-chamber pacemakers are believed to be more physiologic. However, it is not known whether either type of pacemaker results in superior clinical outcomes.MethodsThe Pacemaker Selection in the Elderly study was a 30-month, single-blind, randomized, controlled comparison of ventricular pacing and dual-chamber pacing in 407 patients 65 years of age or older in 29 centers. Patients received a dual-chamber pacemaker that had been randomly programmed to either ventricular pacing or dual-chamber pacing. The primary end point was health-related quality of life as measured by the 36-item Medical Outcomes Study Short-Form General Health Survey.ResultThe average age of the patients was 76 years (range, 65 to 96), and 60 percent were men. Quality of life improved significantly after pacemaker implantation (P
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- 1998
25. Abstract P170: The Association of Urinary Cadmium and Zinc With Lower Extremity Amputations. Evidence From the Strong Heart Study
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Galvez-Fernandez, Marta, primary, Bhatt, Kishan A, additional, Ravalli, Filippo, additional, Goessler, Walter, additional, Zhang, Ying, additional, Fretts, Amanda M, additional, Umans, Jason G, additional, Sanchez, Tiffany, additional, Ujueta, Francisco, additional, Lamas, Gervasio A, additional, Fabsitz, Richard R, additional, and Navas-Acien, Ana, additional
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- 2023
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26. Response to: Letter to the editor by Yen
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Lamas, Gervasio A., primary
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- 2023
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27. CHA2DS2-VASC and CHADS2 Scores Predict Adverse Clinical Events in Patients With Pacemakers and Sinus Node Dysfunction Independent of Atrial Fibrillation
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Glotzer, Taya V., Hellkamp, Anne S., Lee, Kerry L., and Lamas, Gervasio A.
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- 2015
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28. Usefulness of the CHA2DS2VASc Score to Predict Postoperative Stroke in Patients Having Cardiac Surgery Independent of Atrial Fibrillation
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Peguero, Julio G., Issa, Omar, Podesta, Carlos, Elmahdy, Hany M., Santana, Orlando, and Lamas, Gervasio A.
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- 2015
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29. Metal pollutants and cardiovascular disease: Mechanisms and consequences of exposure
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Solenkova, Natalia V., Newman, Jonathan D., Berger, Jeffrey S., Thurston, George, Hochman, Judith S., and Lamas, Gervasio A.
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- 2014
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30. Chelation therapy and cardiovascular disease: Connecting scientific silos to benefit cardiac patients
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Peguero, Julio G., Arenas, Ivan, and Lamas, Gervasio A.
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- 2014
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31. Incidence of cerebrovascular accidents in patients undergoing minimally invasive valve surgery
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LaPietra, Angelo, Santana, Orlando, Mihos, Christos G., DeBeer, Steven, Rosen, Gerald P., Lamas, Gervasio A., and Lamelas, Joseph
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- 2014
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32. EDTA chelation therapy alone and in combination with oral high-dose multivitamins and minerals for coronary disease: The factorial group results of the Trial to Assess Chelation Therapy
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Lamas, Gervasio A., Boineau, Robin, Goertz, Christine, Mark, Daniel B., Rosenberg, Yves, Stylianou, Mario, Rozema, Theodore, Nahin, Richard L., Terry Chappell, L., Lindblad, Lauren, Lewis, Eldrin F., Drisko, Jeanne, and Lee, Kerry L.
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- 2014
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33. Effects of timing, location and definition of reinfarction on mortality in patients with totally occluded infarct related arteries late after myocardial infarction
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Adlbrecht, Christopher, Huber, Kurt, Reynolds, Harmony R., Carvalho, Antonio C., Džavík, Vladimír, Steg, Philippe Gabriel, Liu, Li, Marino, Paolo, Pearte, Camille A., Rankin, James M., White, Harvey D., Lamas, Gervasio A., and Hochman, Judith S.
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- 2014
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34. Hybrid Approach of Percutaneous Coronary Intervention Followed by Minimally Invasive Valve Operations
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Santana, Orlando, Pineda, Andrés M., Cortes-Bergoderi, Mery, Mihos, Christos G., Beohar, Nirat, Lamas, Gervasio A., and Lamelas, Joseph
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- 2014
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35. Chelation therapy to prevent diabetes-associated cardiovascular events
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Diaz, Denisse, Fonseca, Vivian, Aude, Yamil W., and Lamas, Gervasio A.
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- 2018
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36. Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association.
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Lamas, Gervasio A., Bhatnagar, Aruni, Jones, Miranda R., Mann, Koren K., Nasir, Khurram, Tellez-Plaza, Maria, Ujueta, Francisco, and Navas-Acien, Ana
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- 2023
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37. Chronic Toxic Metal Exposure and Cardiovascular Disease: Mechanisms of Risk and Emerging Role of Chelation Therapy
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Aneni, Ehimen C., Escolar, Esteban, and Lamas, Gervasio A.
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- 2016
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38. Edetate Disodium-Based Treatment for Secondary Prevention in Post-Myocardial Infarction Patients
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Lamas, Gervasio A. and Issa, Omar M.
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- 2016
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39. Incidence of postoperative acute kidney injury in patients with chronic kidney disease undergoing minimally invasive valve surgery
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Valdez, Gerson D., Mihos, Christos G., Santana, Orlando, Heimowitz, Todd B., Goldszer, Robert, Lamas, Gervasio A., and Lamelas, Joseph
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- 2013
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40. Incidence of postoperative atrial fibrillation in patients undergoing minimally invasive versus median sternotomy valve surgery
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Mihos, Christos G., Santana, Orlando, Lamas, Gervasio A., and Lamelas, Joseph
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- 2013
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41. Percutaneous revascularization and long term clinical outcomes of diabetic patients randomized in the Occluded Artery Trial (OAT)
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Overgaard, Christopher B., Džavík, Vladimír, Buller, Christopher E., Liu, Li, Banasiak, Waldemar, Devlin, Gerard, Maggioni, Aldo P., Leor, Jonathan, Burton, Jeffery R., Reis, Gilmar, Ruzyllo, Witold, Forman, Sandra A., Lamas, Gervasio A., and Hochman, Judith S.
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- 2013
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42. Infarct Artery Distribution and Clinical Outcomes in Occluded Artery Trial Subjects Presenting With Non–ST-Segment Elevation Myocardial Infarction (from the Long-Term Follow-up of Occluded Artery Trial [OAT])
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Menon, Venu, Ruzyllo, Witold, Carvalho, Antonio C., Almeida de Sousa, Jose Marconi, Forman, Sandra A., Jaworska, Krystyna, Lamas, Gervasio A., Roik, Marek, Thuaire, Christophe, Turgeman, Yoav, and Hochman, Judith S.
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- 2013
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43. Angiotensin Converting Enzyme Inhibitors After and During Acute Coronary Syndromes, and, in Particular, Myocardial Infarction
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Carrillo-Jimenez, Rodolfo, Hennekens, Charles H., Lamas, Gervasio A., and Cannon, Christopher P., editor
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- 2003
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44. Effect of Thromboprophylaxis on Clinical Outcomes After COVID-19 Hospitalization.
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Wang, Tracy Y., Wahed, Abdus S., Morris, Alison, Kreuziger, Lisa Baumann, Quigley, John G., Lamas, Gervasio A., Weissman, Alexandra J., Lopez-Sendon, Jose, Knudson, M. Margaret, Siegal, Deborah M., Kasthuri, Raj S., Alexander, Andrew J., Wahid, Lana, Atassi, Bassel, Miller, Peter J., Lawson, Janice W., Patel, Bela, Krishnan, Jerry A., Shapiro, Nancy L., and Martin, Deborah E.
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COVID-19 ,SARS-CoV-2 Omicron variant ,SARS-CoV-2 Delta variant ,HOSPITAL care ,COVID-19 vaccines - Abstract
Thromboembolism is an important complication in hospitalized patients with COVID-19. This trial sought to determine whether extended thromboprophylaxis after hospital discharge would reduce deaths and thromboembolic events. The trial was done during a time when the Omicron and Delta variants were circulating and COVID-19 hospitalization rates were decreasing. Visual Abstract. Thromboprophylaxis After COVID-19 Hospitalization.: Thromboembolism is an important complication in hospitalized patients with COVID-19. This trial sought to determine whether extended thromboprophylaxis after hospital discharge would reduce deaths and thromboembolic events. The trial was done during a time when the Omicron and Delta variants were circulating and COVID-19 hospitalization rates were decreasing. Background: Patients hospitalized with COVID-19 have an increased incidence of thromboembolism. The role of extended thromboprophylaxis after hospital discharge is unclear. Objective: To determine whether anticoagulation is superior to placebo in reducing death and thromboembolic complications among patients discharged after COVID-19 hospitalization. Design: Prospective, randomized, double-blind, placebo-controlled clinical trial. (ClinicalTrials.gov: NCT04650087) Setting: Done during 2021 to 2022 among 127 U.S. hospitals. Participants: Adults aged 18 years or older hospitalized with COVID-19 for 48 hours or more and ready for discharge, excluding those with a requirement for, or contraindication to, anticoagulation. Intervention: 2.5 mg of apixaban versus placebo twice daily for 30 days. Measurements: The primary efficacy end point was a 30-day composite of death, arterial thromboembolism, and venous thromboembolism. The primary safety end points were 30-day major bleeding and clinically relevant nonmajor bleeding. Results: Enrollment was terminated early, after 1217 participants were randomly assigned, because of a lower than anticipated event rate and a declining rate of COVID-19 hospitalizations. Median age was 54 years, 50.4% were women, 26.5% were Black, and 16.7% were Hispanic; 30.7% had a World Health Organization severity score of 5 or greater, and 11.0% had an International Medical Prevention Registry on Venous Thromboembolism risk prediction score of greater than 4. Incidence of the primary end point was 2.13% (95% CI, 1.14 to 3.62) in the apixaban group and 2.31% (CI, 1.27 to 3.84) in the placebo group. Major bleeding occurred in 2 (0.4%) and 1 (0.2%) and clinically relevant nonmajor bleeding occurred in 3 (0.6%) and 6 (1.1%) apixaban-treated and placebo-treated participants, respectively. By day 30, thirty-six (3.0%) participants were lost to follow-up, and 8.5% of apixaban and 11.9% of placebo participants permanently discontinued the study drug treatment. Limitations: The introduction of SARS-CoV-2 vaccines decreased the risk for hospitalization and death. Study enrollment spanned the peaks of the Delta and Omicron variants in the United States, which influenced illness severity. Conclusion: The incidence of death or thromboembolism was low in this cohort of patients discharged after hospitalization with COVID-19. Because of early enrollment termination, the results were imprecise and the study was inconclusive. Primary Funding Source: National Institutes of Health. [ABSTRACT FROM AUTHOR]
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- 2023
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45. Angiotensin-Converting Enzyme Inhibitors in Acute Coronary Syndromes
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Rosado, Antonio, Lamas, Gervasio A., and Cannon, Christopher P., editor
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- 1999
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46. Heart Failure in Post-MI Patients With Persistent IRA Occlusion: Prevalence, Risk Factors, and the Long-Term Effect of PCI in the Occluded Artery Trial (OAT)
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Jhaveri, Rahul R., Reynolds, Harmony R., Katz, Stuart D., Jeger, Raban, Zinka, Elzbieta, Forman, Sandra A., Lamas, Gervasio A., and Hochman, Judith S.
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- 2012
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47. Effect of Late Revascularization of a Totally Occluded Coronary Artery After Myocardial Infarction on Mortality Rates in Patients With Renal Impairment
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Hastings, Ramin S., Hochman, Judith S., Dzavik, Vladimir, Lamas, Gervasio A., Forman, Sandra A., Schiele, Francois, Michalis, Lampros K., Nikas, Dimitris, Jaroch, Joanna, and Reynolds, Harmony R.
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- 2012
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48. Staged percutaneous coronary intervention and minimally invasive valve surgery: Results of a hybrid approach to concomitant coronary and valvular disease
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Santana, Orlando, Funk, Michael, Zamora, Carlos, Escolar, Esteban, Lamas, Gervasio A., and Lamelas, Joseph
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- 2012
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49. Long-term outcomes after a strategy of percutaneous coronary intervention of the infarct-related artery with drug-eluting stents or bare metal stents vs medical therapy alone in the Occluded Artery Trial (OAT)
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Freixa, Xavier, Džavík, Vladimír, Forman, Sandra A., Rankin, James M., Buller, Christopher E., Cantor, Warren J., Ruzyllo, Witold, Reynolds, Harmony R., Lamas, Gervasio A., and Hochman, Judith S.
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- 2012
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50. Reinfarction after percutaneous coronary intervention or medical management using the universal definition in patients with total occlusion after myocardial infarction: Results from long-term follow-up of the Occluded Artery Trial (OAT) cohort
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White, Harvey D., Reynolds, Harmony R., Carvalho, Antonio C., Pearte, Camille A., Liu, Li, Martin, C. Edwin, Knatterud, Genell L., Džavík, Vladimír, Kruk, Mariusz, Steg, Philippe Gabriel, Cantor, Warren J., Menon, Venu, Lamas, Gervasio A., and Hochman, Judith S.
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- 2012
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