1. Relaxometry and contrast-free cerebral microvascular quantification using balanced Steady-State Free Precession MR Fingerprinting
- Author
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Coudert, Thomas, Delphin, Aurélien, Barrier, Antoine, Legris, Loïc, Warnking, Jan M, Lamalle, Laurent, Doneva, Mariya, Lemasson, Benjamin, Barbier, Emmanuel L, and Christen, Thomas
- Subjects
Physics - Medical Physics - Abstract
This study proposes a novel, contrast-free Magnetic Resonance Fingerprinting (MRF) method using balanced Steady-State Free Precession (bSSFP) sequences for the quantification of cerebral blood volume (CBV), vessel radius (R), and relaxometry parameters (T1, T2 T2*) in the brain. The technique leverages the sensitivity of bSSFP sequences to intra-voxel frequency distributions in both transient and steady-state regimes. A dictionary-matching process is employed, using simulations of realistic mouse microvascular networks to generate the MRF dictionary. The method is validated through in silico studies and in vivo experiments on six healthy subjects, comparing results with standard MRF methods and literature values. The proposed method shows strong correlation and agreement with standard MRF methods for T1 and T2 values. High-resolution maps provide detailed visualizations of CBV and microvascular structures, highlighting differences in white matter (WM) and grey matter (GM) regions. The measured GM/WM ratio for CBV is 1.91, consistent with literature values. This contrast-free bSSFP-based MRF method offers an innovative approach for quantifying CBV, vessel radius, and relaxometry parameters. Further validation against DSC imaging and clinical studies in pathological conditions is warranted to confirm its clinical utility., Comment: Main text : 24 pages. 9 main Figures, 1 main Table, Supplementary material : 9 pages, 8 figures and 1 table
- Published
- 2024
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