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9. Superconductivity in Ba_2Sn_3Sb_6 and SrSn_3Sb_4

Author

Deakin, Laura, Lam, Robert, Marsiglio, Frank, and Mar, Arthur

Subjects
Condensed Matter - Superconductivity, Condensed Matter - Materials Science
Abstract

Resistivity and ac magnetic susceptibility measurements on Ba2Sn3Sb6 and SrSn3Sb4 indicate that these Zintl compounds display a transition to a superconducting phase at Tc = 3.9 K. The Meissner effect was observed for Ba2Sn3Sb6 under an applied field of 25 Oe. The signatures for superconductivity, such as high and low velocity conduction electrons and lone pairs, are present for both of these compounds., Comment: 11 pages, 3 figures

Published
2002

16. Design of Nanodiamond Based Drug Delivery Patch for Cancer Therapeutics and Imaging Applications

Author

Liu, Wing Kam, Adnan, Ashfaq, Kopacz, Adrian M., Hallikainen, Michelle, Ho, Dean, Lam, Robert, Lee, Jessica, Belytschko, Ted, Schatz, George, Tzeng, Yonhua, Kim, Young-Jin, Baik, Seunghyun, Kim, Moon Ki, Kim, Taesung, Lee, Junghoon, Hwang, Eung-Soo, Im, Seyoung, Ōsawa, Eiji, Barnard, Amanda, Chang, Huan-Cheng, Chang, Chia-Ching, Oñate, Eugenio, and Ho, Dean, editor

Published
2010
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21. Evaluation of a Student-Older Adult Telephone Befriending Program to Reduce Social Isolation during the COVID-19 Pandemic: A Pilot Evaluation

Author

Ahuja, Manan, Lewis, Kaitlin, Kim, Leanne, Owais, Sawayra, Compagnone, Jordana, Fallico, Laura, Fishbein, Francine, Stefanova, Isabella, Xu, Kai Man, Boulos, Mary, Gui, Shannon, Basu, Monisha, Cooper, Tracy, Kay, Kelly, Hogan, David B., Morais, José A., Molnar, Frank, Lam, Robert E., Borrie, Michael J., Koerber, Raphaelle, Vaccarello, Linh, Ho, Allan, MacKay, Scott, Ebert, Patricia, Harbridge, Cathy, Hogan, David, Mukharyamova, Alfiya, Foster, Nicoda, Wang, Irene, Kabitsis, Pauline P., Hamelin, Mary Ann, Troung, Nga, Lee, Janny, Sinha, Samir K., Thompson, Cody, Bharadia, Morgan, Sadowski, Cheryl, Chuen, Victoria, Chan, Adrian, Alibhai, Shabbir, Chau, Vicky, Dholakia, Saumil, Bagheri, Alireza, Simpson, Alexander (Sandy), Hewitt, David, Ratcliffe, Michael, Booth, Dr Malcolm, Lafleur, Benoit, Jibb, Samantha, Gingrich, Shaen, Lane, Susan, Clarke, Jo-Anne, Fat, Guillaume Lim, Gopaul, Aquila, Pananos, Demetri, Taabazuing, Mary-Margaret, Schnarr, Lindsay, Bater, Marilyn, Dai, Serina, Freedman, Amy, Degan, Sophie Del, Forget, Marie-France, Leblanc, Julie, Desjardins, Michaël, Durand, Madeleine, Vu, Thien Tuong Minh, Nguyen, Quoc Dinh, Desmarais, Philippe, Miles, Amy, Norris, Mireille, Reppas-Rindlisbacher, Christina, Finlay, Jessica M, Mahar, Alyson, Siddhpuria, Shailee, Hallet, Julie, Rochon, Paula, Kobayashi, Lindsay C, Wong, Eric, Gormley, Jessica, Lee, Justin, Conroy, Maeve, Patterson, Christopher, Xu, Victoria YY, Sham, Rosalind, Moy, Sally, Naglie, Gary, Smith, Jagger, Mahon, Joel, Almeida, Quincy, Bherer, Louis, Burhan, Amer, Liu-Ambrose, Teresa, Middleton, Laura, Nagamatsu, Lindsay, Speechley, Mark, Montero-Odasso, Manuel, Osman, Abdelhady, Ali, Shehzad, Payen, Anaïs, Beuscart, Jean-Baptiste, Soula, Julien, Verloop, David, Defebvre, Marguerite-Marie, Dambre, Delphine, Godard-Sebillotte, Claire, Pieruccini-Faria, Frederico, Haddad, Seyyed, Cornish, Ben, McIlroy, Bill, Bartha, Rob, Investigators, All ONDRI, Searle, Samuel, Walsh, Steve, Davis, Giselle, Mercier, Tara, Rockwood, Kenneth, Davis, Daniel, Haroon, Babar, Sultana, Munira, Campbell, Karen, Jennings, Morgan, Orange, Joseph B., Knowlton, Jill, George, Armin St., Bryant, Dianne, Akter, Ripa, Kim, Kristine, Huang, Allen, Arsenault-Lapierre, Geneviève, Bui, Tammy, Sourial, Nadia, Quesnel-Vallée, Amélie, Massamba, Victoria, Rochette, Louis, Morgan, Debra, Kosteniuk, Julie, Vedel, Isabelle, Aubin, Vincent, Paquet, Steve, Durand, Pierre J., Pageau, Félix, Bharaj, Neetika, Suárez, Pablo Solla, Obrand, Jeremy, Chetrit, Jessica, Ahmad, Fayeza, Lantagne, Sarah, Morrison, David, Xue, Xiaoqing, Afilalo, Marc, Richards, Brent, Afilalo, Jonathan, Bray, Nick W, Witt, Suzanne T, Bartha, Robert, Doherty, Timothy J, Nagamatsu, Lindsay S, Almeida, Quincy J, Arsenault-Lapierre, Genevieve, Cameron, Julie, Kolomitro, Klodiana, Dalgarno, Nancy, Turnnidge, Jennifer, Pelland, Lucie, Auais, Mohammad, Carr, Frances, Morgan, Angela, Devapura, Shehani, Williams, Christina, Symon, Jennifer, Howe-Riddell, Carolyn, Miller, Angela, Boone, Jennifer, Ebbage, Kevin, Jadaviji, Shalmin, Mathura, Pamela, Charles, Lesley, Parmar, Jasneet, Suzette, Brémault-Phillips, Pike, Ashley, Dobbs, Bonnie, Tian, Peter George, Piazza, Nicolo, Goldfarb, Michael, Martucci, Giuseppe, Rudski, Lawrence, Spaziano, Marco, Morin, Jean-Francois, Lachapelle, Kevin, Langlois, Yves, D’Amico, Danielle, Yusupov, Iris, Zhu, Lynn, Lass, Jordan W., Levine, Brian, Vandermorris, Susan, Troyer, Angela K., Ewa, Vivian, Lee, Jennifer, Jones, Chris, Gutscher, Abram, Feng, Chengying, Adebero, Tony, DePaul, Vincent, Vafaei, Afshin, Norman, Kathleen, Gallibois, Molly, Rogers, Kyle, Folkins, Chris, Jarrett, Pamela, Magalhaes, Sandra, Gibson, Kirstian, Gao, Yuchen, Ottley, Katherine M., Qiao, Thomas, Myge, Ivy, Compton, Roslyn M., Wickson-Griffiths, Abigail, Hunter, Paulette V., Network, Saskatchewan Long-Term Care, Gill, Navjot, Connelly, Denise, Godwin, Bradley, Hanson, Natasha, Kervin, Emily, Skerry, Leanne, McCloskey, Rose, Hassanabadi, Nazila, Berger, Claudie, Papaioannou, Alexandra, Cheung, Angela M, Rahme, Elham, Leslie, William D, Goltzman, David, Morin, Suzanne, Hogeveen, Sophie, Heckman, George, Milne, Kelly, Hirdes, John, Horne, Natalie, Marshall, Emily, Andrew, Melissa, Hunter, Susan, Somerville, Lyndsay, Lanting, Brent, Ivo, Jessica, Pitre, Teresa, Faisal, Sadaf, Antunes, Kristen, Oda, Kasumi, Patel, Tejal, Jacob, Gabriella, Sherwood, Malcolm, Malik, Shabhaz, Baker, Jacquie, Bhangu, Jaspreet, Khoury, Lara, Moors, Joy, Lampron, Jacynthe, Figueira, Sonshire, Nemnom, Marie-Joe, Eagles, Debra, Koop, Jennifer, Lee, Linda, Hillier, Loretta M., Gregg, Susie, Hickman, Kathy, Agla, Caitlin, Carducci, Jillian, Skimson, Kara, Dillon-Martin, Sharon, Kuzych, Lissa, Beuermann, Lindsay, Parikh, Ruchi, Lee, Catherine, Lee, Ahreum, McArthur, Caitlin, Ioannidis, George, Adachi, Jonathan D, Griffith, Lauren E, Thabane, Lehana, Giangregorio, Lora, Morin, Suzanne N, Madden, Kenneth, Feldman, Boris, Arishenkoff, Shane, Meneilly, Graydon, Mah, Jasmine, Godin, Judith, Stevens, Susan, Keefe, Janice, Sun, Michael, Goodwin, Josh, Cheung, Bonnie, von Maltzahn, Maia, Mailhot, Tanya, Clausen, Christina, Crump, Laura, Leblanc, Marie-Eve, Sanzone, Lia, Marr, Sharon, Doherty, Michelle, Siemon, Jennifer, Hillier, Loretta, Milroy, Desmond, Marrone, Erica, Maalouf, Mona, Moorhouse, Paige, Shetty, Nabha, Mallery, Laurie, Miller, Ashley, VonMaltzahn, Maia, Naug, Anne Marie Krueger, Tinning, Amanda, Buckler, Melissa, Stasiulis, Elaine, Sandhu, Harvir, Brookes, Jahnel, Vrkljan, Brenda, Mariano, Claudia, Gélinas, Isabelle, Byszewski, Anna, Rapoport, Mark J., Sanford, Sarah, Bédard, Michel, Belchior, Patricia, Crizzle, Alexander, Marshall, Shawn, Rapoport, Mark, Nene, Sofia, Bennett, Roxanne, Morin, Suzanne N., Nixon, Lara, Sampson, Megan, Punungwe, Fadzai Moreblessing, Kelly, Martina, Nuique, Kate, Papillon-Ferland, Louise, Castonguay, Valérie, Anderson, Sharon, Pollard, Cheryl, Poole, Lisa, Leslie, Myles, McGhan, Gwen, Weir, Carolyn, Pooler, Charlotte, Stickney-Lee, Jennifer, Shapkin, Kimberly, Peyrusqué, Eva, Kergoat, Marie-Jeanne, Bolduc, Aline, Buckinx, Fanny, Law, Caroline, Veillette, Nathalie, Fonseca, Raquel, Aubertin-Leheudre, Mylène, Quan, Samuel, Menec, Verena, O’Connell, Megan, Cloutier, Denise, Newall, Nancy, Tate, Robert, John, Philip St., Qureshi, Natasha, Djekic-Ivankovic, Maria, Wall, Michelle, Berry, Gregory, Mayo, Nancy, Gélinas, Céline, Funnell, Larry, Racey, Megan, Markle-Reid, Maureen, Fitzpatrick-Lewis, Donna, Ali, Muhammad Usman, Gagné, Hélène, Ploeg, Jenny, Sztramko, Richard, Harrison, Lisa, Sherifali, Diana, Sacco, Veronica, Stolee, Paul, Boscart, Veronique, MacEachen, Ellen, Malik, Shabaz, Borrie, Micheal, Fogarty, Jennifer, Savage, Rachel, Sirisegaram, Luxey, Thain, Jenny, Diachun, Laura, Lingard, Lorelei, Cristancho, Sayra, Triscott, Jean, Huang, James, Moores, David, Tian, Peter George Jaminal, and Cerna, Judith

Subjects
Abstracts, Eligible for the Edmund V. Cowdry Award, Finalists for the Willard and Phoebe Thompson Award, Posters, Eligible for the Réjean Hébert Canadian Institutes of Health Research - Institute on Aging Prize, Eligible for the Dr. Jack & Dr. ASA Award
Published
2021

22. Concurrent PANK2 and OCA2 variants in a patient with retinal dystrophy, hypopigmented irides and neurodegeneration.

Author

Wong, Eva Wai Nam, Cheng, Shirley S.W., Woo, Tiffany T.Y., Lam, Robert F., and Lai, Frank H.P.

Subjects
DYSTROPHY, RETINAL degeneration, NEURODEGENERATION, MISSENSE mutation, OCULAR manifestations of general diseases, GENETIC testing
Abstract

To report a case of concurrent pantothenate kinase-associated neurodegeneration (PKAN) and oculocutaneous albinism (OCA) with dual PANK2 and OCA2 variants in a Chinese patient who presented with early-onset reduced vision, nyctalopia, and neurological symptoms. Based on the ocular phenotype and provisional diagnosis of rod-cone dystrophy, genetic testing was pursued. Peripheral blood DNA extraction was carried out with the next-generation sequencing technique, which involved a population-specific medical exome virtual panel. Pre- and post-test counseling were carried out by clinical geneticists. Homozygous missense variants in PANK2 {NM_153638.3}:c.655 G>A (p.(Gly219Ser)) and OCA2{NM_025160.6}:c.1327 G>A(p.(Val443Ile)) were identified. The molecular diagnoses of pantothenate kinase associated neurodegeneration (OMIM#234200) and albinism, oculocutaneous, type II (OMIM#203200) were supported by clinical findings. Two rare autosomal recessive diseases, pantothenate kinase-associated neurodegeneration (PKAN) and oculocutaneous albinism (OCA) were detected in our patient. Ocular and systemic manifestations, as well as neuroimaging findings were compatible with the diseases identified. Genetic analysis is imperative in making an accurate molecular diagnosis in these rare conditions to allow timely counseling, disease prognostication and management. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Contributors

Author

Balogun, Oluwafemi O., Banini, Bubu A., Beier, Juliane I., Cheng, Katherine, Corey, Kathleen E., Crocombe, Dominic, Di Bartolomeo, Anna, Do, Albert, Fan, Jian-Gao, Fan, Weiguo, George, Jacob, Goens, Donald, Golabi, Pegah, Henry, Linda, Horn, Paul, Huang, Jee-Fu, Huang, Daniel Q., Ito, Takanori, Johnson-Mann, Crystal N., Jun, Dae Won, Kaya, Eda, Kim, Sun H., Kwo, Paul Y., Lam, Robert, Li, Guanlin, Lim, Joseph K., Lin, Huapeng, Medici, Valentina, Muthiah, Mark, Newsome, Philip N., Ng, Cheng Han, Nguyen, Mindie H., Oh, Joo Hyun, Patton, Heather, Rosenthal, Philip, Shaikh, Emad S., Spencer, Sean, Takahashi, Hirokazu, Teng, Margaret L.P., Tsochatzis, Emmanuel A., Török, Natalie J., Wong, Vincent Wai-Sun, Wong, Grace Lai-Hung, Yang, Rui-Xu, Yeh, Ming-Lun, Yeo, Yee Hui, Yilmaz, Yusuf, Younossi, Zobair M., Yu, Ming-Lung, Zarrinpar, Amir, and Zhang, Xinrong

Published
2024
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32. Signal transfer in human protein tyrosine phosphatase PTP1B from allosteric inhibitor P00058

Author

Chirgadze, Yuri N., primary, Battaile, Kevin P., additional, Likhachev, Ilya V., additional, Balabaev, Nikolay K., additional, Gordon, Roni D., additional, Romanov, Vladimir, additional, Lin, Andres, additional, Karisch, Robert, additional, Lam, Robert, additional, Ruzanov, Max, additional, Brazhnikov, Evgeniy V., additional, Pai, Emil F., additional, Neel, Benjamin G., additional, and Chirgadze, Nickolay Y., additional

Published
2021
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39. Advancements in ophthalmic imaging for better understanding of pachychoroid spectrum diseases: perspective.

Author

Eva Wai Nam Wong, Fung Lam, Robert, and Hiu Ping Lai, Frank

Subjects
EYE diseases, COMPUTED tomography, FLUORESCENCE angiography, OPTICAL coherence tomography, NEOVASCULARIZATION
Abstract

Pachychoroid disease spectrum encompasses entities with pathogenesis of choroidal circulatory dysfunction. Advancements in ophthalmic imaging enables better understanding of its structural and functional implications. This perspective article covers clinical features, ocular imaging findings, and management options of pachychoroid spectrum diseases including central serous chorioretinopathy, pachychoroid pigment epitheliopathy, pachychoroid neovasculopathy, polypoidal choroidal vasculopathy or aneurysmal type 1 neovascularization, focal choroidal excavation, and peripapillary pachychoroid syndrome. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Structure and protein-protein interaction studies on Chlamydia trachomatis protein CT670 (YscO homolog)

Author

Lorenzini, Emily, Singer, Alexander, Singh, Bhag, Lam, Robert, Skarina, Tatiana, Chirgadze, Nickolay Y., Savchenko, Alexei, and Gupta, Radhey S.

Subjects
Chlamydia trachomatis -- Genetic aspects, Chlamydia trachomatis -- Research, Protein-protein interactions -- Research, Proteins -- Structure, Proteins -- Research, Biological sciences
Abstract

Comparative genomic studies have identified many proteins that are found only in various Chlamydiae species and exhibit no significant sequence similarity to any protein in organisms that do not belong to this group. The CT670 protein of Chlamydia trachomatis is one of the proteins whose genes are in one of the type III secretion gene clusters but whose cellular functions are not known. CT670 shares several characteristics with the YscO protein of Yersinia pestis, including the neighboring genes, size, charge, and secondary structure, but the structures and/or functions of these proteins remain to be determined. Although a BLAST search with CT670 did not identify YscO as a related protein, our analysis indicated that these two proteins exhibit significant sequence similarity. In this paper, we report that the CT670 crystal, solved at a resolution of 2 [Angstrom], consists of a single coiled coil containing just two long helices. Gel filtration and analytical ultracentrifugation studies showed that in solution CT670 exists in both monomeric and dimeric forms and that the monomer predominates at lower protein concentrations. We examined the interaction of CT670 with many type III secretion system-related proteins (viz., CT091, CT665, CT666, CT667, CT668, CT669, CT671, CT672, and CT673) by performing bacterial two-hybrid assays. In these experiments, CT670 was found to interact only with the CT671 protein (YscP homolog), whose gene is immediately downstream of ct670. A specific interaction between CT670 and CT671 was also observed when affinity chromatography pull-down experiments were performed. These results suggest that CT670 and CT671 are putative homologs of the YcoO and YscP proteins, respectively, and that they likely form a chaperone-effector pair. doi: 10.1128/JB.01479-09

Published
2010

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