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270 results on '"Lam, Marnix G.E.H."'

2. Extrahepatic perfusion and incomplete hepatic perfusion after hepatic arterial infusion pump implantation: incidence and clinical implications

Author

Filipe, Wills F., Buisman, Florian Buismanz, Koerkamp, Bas Groot, Grunhagen, Dirk J., Homs, Marjolein Y.V., Verhoef, Cornelis, Moelker, Adriaan, Graven, Laura, Franssen, Stijn, Gobardhan, Paul D., Loosveld, Olaf J.L., Pool, Stefan, Mieog, J. Sven D., Speetjens, Frank M., Rietbergen, Daphne D.D., Burgmans, Mark C., Doornesbosch, Pascal G., Patijn, Gijs A., de Groot, Jan Willem B., Meier, Mark A.J., Oostdijk, Ad H.J., Boluis, Karen, Grootscholten, Cecile, klompenhouwer, Elizabeth G., Kok, Niels F.M., kuhlmann, Koert, F.D., Krul, Myrtle F., Versleijen, Michelle W.J., Bruijnen, Rutger C.G., Hagendoorn, Jroen, Lam, Marnix G.E.H., Roodhart, Jeanine M.L., Bennink, Roel J., van Delden, Otto M., Swijnenburg, Rutger-Jan, Buffart, Tineke E., Borel Rinkes, Inne H.M., Cercek, Andrea, Kemeny, Nancy E., Peter Kingham, T., D’Angelica, Michael, van Bommel, Christian P.H., van Doorn, Leni, Ayez, Ninos, Vermaas, Maarten, Nieuwenhuijse, Vincent B., Buisman, Florian E., Grünhagen, Dirk J., Bolhuis, Karen, Doornebosch, Pascal G., Hagendoorn, Jeroen, Harmsen, Paul, Klompenhouwer, Elizabeth G., Outmani, Loubna, Swijnenburg, Rutger Jan, Kuhlmann, Koert F.D., and Groot Koerkamp, Bas

Published
2024
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5. Hepatic Radioembolization

Author

Ramdhani, K., primary, Lam, Marnix G.E.H., additional, Braat, Arthur J.A.T., additional, Smits, Maarten L.J., additional, and El-Haddad, Ghassan, additional

Published
2024
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11. The additional value of 68Ga-PSMA PET/CT SUVmax in predicting ISUP GG ≥ 2 and ISUP GG ≥ 3 prostate cancer in biopsy

Author

Researchgr. Nucleaire Geneeskunde, Cancer, Heetman, Joris G., Paulino Pereira, Leonor J., Kelder, Johannes C., Soeterik, Timo F.W., Wever, Lieke, Lavalaye, Jules, van der Hoeven, Erik J.R.J., Lam, Marnix G.E.H., van Melick, Harm H.E., van den Bergh, Roderick C.N., Researchgr. Nucleaire Geneeskunde, Cancer, Heetman, Joris G., Paulino Pereira, Leonor J., Kelder, Johannes C., Soeterik, Timo F.W., Wever, Lieke, Lavalaye, Jules, van der Hoeven, Erik J.R.J., Lam, Marnix G.E.H., van Melick, Harm H.E., and van den Bergh, Roderick C.N.

Published
2024

12. Hepatic Radioembolization: A Multistep Theragnostic Procedure

Author

Researchgr. Nucleaire Geneeskunde, Cancer, MS Radiologie, Ramdhani, K., Lam, Marnix G.E.H., Braat, Arthur J.A.T., Smits, Maarten L.J., El-Haddad, Ghassan, Researchgr. Nucleaire Geneeskunde, Cancer, MS Radiologie, Ramdhani, K., Lam, Marnix G.E.H., Braat, Arthur J.A.T., Smits, Maarten L.J., and El-Haddad, Ghassan

Published
2024

13. Advances in Radionuclide Therapies for Patients with Neuro-endocrine Tumors

Author

MS Endocriene Oncologie, Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, Hoogenkamp, Denise S., de Wit–van der Veen, Linda J., Huizing, Daphne M.V., Tesselaar, Margot E.T., van Leeuwaarde, Rachel S., Stokkel, Marcel P.M., Lam, Marnix G.E.H., Braat, Arthur J.A.T., MS Endocriene Oncologie, Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, Hoogenkamp, Denise S., de Wit–van der Veen, Linda J., Huizing, Daphne M.V., Tesselaar, Margot E.T., van Leeuwaarde, Rachel S., Stokkel, Marcel P.M., Lam, Marnix G.E.H., and Braat, Arthur J.A.T.

Published
2024

16. Preoperative Prediction of Pathologic Response to Neoadjuvant Chemoradiotherapy in Patients With Esophageal Cancer Using 18F-FDG PET/CT and DW-MRI: A Prospective Multicenter Study

Author

Borggreve, Alicia S., Goense, Lucas, van Rossum, Peter S.N., Heethuis, Sophie E., van Hillegersberg, Richard, Lagendijk, Jan J.W., Lam, Marnix G.E.H., van Lier, Astrid L.H.M.W., Mook, Stella, Ruurda, Jelle P., van Vulpen, Marco, Voncken, Francine E.M., Aleman, Berthe M.P., Bartels-Rutten, Annemarieke, Ma, Jingfei, Fang, Penny, Musall, Benjamin C., Lin, Steven H., and Meijer, Gert J.

Published
2020
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28. Dose finding study for unilobar radioembolization using holmium-166 microspheres to improve resectability in patients with HCC:the RALLY protocol

Author

Andel, Daan, Lam, Marnix G.E.H., de Bruijne, Joep, Smits, Maarten L.J., Braat, Arthur J.A.T., Moelker, Adriaan, Vegt, Erik, Ruiter, Simeon J.S., Noordzij, Walter, Grazi, Gianluca, Vallati, Giulio E., Bennink, Roel J., van Delden, Otto M., Kranenburg, Onno W., Ijzermans, Jan N.M., Nijkamp, Maarten W., Erdmann, Joris I., Sciuto, Rosa, Hagendoorn, Jeroen, Borel Rinkes, Inne H.M., Andel, Daan, Lam, Marnix G.E.H., de Bruijne, Joep, Smits, Maarten L.J., Braat, Arthur J.A.T., Moelker, Adriaan, Vegt, Erik, Ruiter, Simeon J.S., Noordzij, Walter, Grazi, Gianluca, Vallati, Giulio E., Bennink, Roel J., van Delden, Otto M., Kranenburg, Onno W., Ijzermans, Jan N.M., Nijkamp, Maarten W., Erdmann, Joris I., Sciuto, Rosa, Hagendoorn, Jeroen, and Borel Rinkes, Inne H.M.

Abstract

Background: High dose unilobar radioembolization (also termed ‘radiation lobectomy’)—the transarterial unilobar infusion of radioactive microspheres as a means of controlling tumour growth while concomitantly inducing future liver remnant hypertrophy—has recently gained interest as induction strategy for surgical resection. Prospective studies on the safety and efficacy of the unilobar radioembolization-surgery treatment algorithm are lacking. The RALLY study aims to assess the safety and toxicity profile of holmium-166 unilobar radioembolization in patients with hepatocellular carcinoma ineligible for surgery due to insufficiency of the future liver remnant. Methods: The RALLY study is a multicenter, interventional, non-randomized, open-label, non-comparative safety study. Patients with hepatocellular carcinoma who are considered ineligible for surgery due to insufficiency of the future liver remnant (< 2.7%/min/m2 on hepatobiliary iminodiacetic acid scan will be included. A classical 3 + 3 dose escalation model will be used, enrolling three to six patients in each cohort. The primary objective is to determine the maximum tolerated treated non-tumourous liver-absorbed dose (cohorts of 50, 60, 70 and 80 Gy). Secondary objectives are to evaluate dose–response relationships, to establish the safety and feasibility of surgical resection following unilobar radioembolization, to assess quality of life, and to generate a biobank. Discussion: This will be the first clinical study to assess the unilobar radioembolization-surgery treatment algorithm and may serve as a stepping stone towards its implementation in routine clinical practice. Trial registration: Netherlands Trial Register NL8902 , registered on 2020–09-15.

Published
2023

29. Evaluating the Targeting of a Staphylococcus-aureus-Infected Implant with a Radiolabeled Antibody In Vivo

Author

van Dijk, Bruce (author), Hooning van Duyvenbode, J. Fred F. (author), de Vor, Lisanne (author), Nurmohamed, F. Ruben H.A. (author), Lam, Marnix G.E.H. (author), Poot, Alex J. (author), Ramakers, R.M. (author), Koustoulidou, Sofia (author), Beekman, F.J. (author), Weinans, Harrie (author), van Dijk, Bruce (author), Hooning van Duyvenbode, J. Fred F. (author), de Vor, Lisanne (author), Nurmohamed, F. Ruben H.A. (author), Lam, Marnix G.E.H. (author), Poot, Alex J. (author), Ramakers, R.M. (author), Koustoulidou, Sofia (author), Beekman, F.J. (author), and Weinans, Harrie (author)

Abstract

Implant infections caused by Staphylococcus aureus are difficult to treat due to biofilm formation, which complicates surgical and antibiotic treatment. We introduce an alternative approach using monoclonal antibodies (mAbs) targeting S. aureus and provide evidence of the specificity and biodistribution of S.-aureus-targeting antibodies in a mouse implant infection model. The monoclonal antibody 4497-IgG1 targeting wall teichoic acid in S. aureus was labeled with indium-111 using CHX-A”-DTPA as a chelator. Single Photon Emission Computed Tomography/computed tomographyscans were performed at 24, 72 and 120 h after administration of the 111In-4497 mAb in Balb/cAnNCrl mice with a subcutaneous implant that was pre-colonized with S. aureus biofilm. The biodistribution of this labelled antibody over various organs was visualized and quantified using SPECT/CT imaging, and was compared to the uptake at the target tissue with the implanted infection. Uptake of the 111In-4497 mAbs at the infected implant gradually increased from 8.34 %ID/cm3 at 24 h to 9.22 %ID/cm3 at 120 h. Uptake at the heart/blood pool decreased over time from 11.60 to 7.58 %ID/cm3, whereas the uptake in the other organs decreased from 7.26 to less than 4.66 %ID/cm3 at 120 h. The effective half-life of 111In-4497 mAbs was determined to be 59 h. In conclusion, 111In-4497 mAbs were found to specifically detect S. aureus and its biofilm with excellent and prolonged accumulation at the site of the colonized implant. Therefore, it has the potential to serve as a drug delivery system for the diagnostic and bactericidal treatment of biofilm., RST/Technici Pool, RST/Biomedical Imaging, Biomaterials & Tissue Biomechanics

Published
2023
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30. A meta-analysis on the diagnostic performance of whole-body MRI for the initial staging of Hodgkin lymphoma in children and adults using FDG-PET/CT as a reference standard

Author

Onderzoek Beeld, MS Radiologie, Cancer, PMC Medisch specialisten, Researchgr. Nucleaire Geneeskunde, Child Health, Arts-assistenten Radiologie, Spijkers, Suzanne, Littooij, Annemieke S., Beishuizen, Auke, Lam, Marnix G.E.H., Nievelstein, Rutger A.J., Onderzoek Beeld, MS Radiologie, Cancer, PMC Medisch specialisten, Researchgr. Nucleaire Geneeskunde, Child Health, Arts-assistenten Radiologie, Spijkers, Suzanne, Littooij, Annemieke S., Beishuizen, Auke, Lam, Marnix G.E.H., and Nievelstein, Rutger A.J.

Published
2023

31. Current status of yttrium-90 microspheres radioembolization in primary and metastatic liver cancer

Author

Researchgr. Nucleaire Geneeskunde, Cancer, MS Radiologie, Other research (not in main researchprogram), Anbari, Yasaman, Veerman, Floortje E., Keane, Grace, Braat, Arthur J.A.T., Smits, Maarten L.J., Bruijnen, Rutger C.G., Tan, Wenle, Li, Ye, Duan, Feng, Lam, Marnix G.E.H., Researchgr. Nucleaire Geneeskunde, Cancer, MS Radiologie, Other research (not in main researchprogram), Anbari, Yasaman, Veerman, Floortje E., Keane, Grace, Braat, Arthur J.A.T., Smits, Maarten L.J., Bruijnen, Rutger C.G., Tan, Wenle, Li, Ye, Duan, Feng, and Lam, Marnix G.E.H.

Published
2023

32. Dose finding study for unilobar radioembolization using holmium-166 microspheres to improve resectability in patients with HCC: the RALLY protocol

Author

MS HOD, Lab Translational Oncology, Researchgr. Nucleaire Geneeskunde, Cancer, MS MDL 1, MS Radiologie, Regenerative Medicine and Stem Cells, MS CGO, Andel, Daan, Lam, Marnix G.E.H., de Bruijne, Joep, Smits, Maarten L.J., Braat, Arthur J.A.T., Moelker, Adriaan, Vegt, Erik, Ruiter, Simeon J.S., Noordzij, Walter, Grazi, Gianluca, Vallati, Giulio E., Bennink, Roel J., van Delden, Otto M., Kranenburg, Onno W., Ijzermans, Jan N.M., Nijkamp, Maarten W., Erdmann, Joris I., Sciuto, Rosa, Hagendoorn, Jeroen, Borel Rinkes, Inne H.M., MS HOD, Lab Translational Oncology, Researchgr. Nucleaire Geneeskunde, Cancer, MS MDL 1, MS Radiologie, Regenerative Medicine and Stem Cells, MS CGO, Andel, Daan, Lam, Marnix G.E.H., de Bruijne, Joep, Smits, Maarten L.J., Braat, Arthur J.A.T., Moelker, Adriaan, Vegt, Erik, Ruiter, Simeon J.S., Noordzij, Walter, Grazi, Gianluca, Vallati, Giulio E., Bennink, Roel J., van Delden, Otto M., Kranenburg, Onno W., Ijzermans, Jan N.M., Nijkamp, Maarten W., Erdmann, Joris I., Sciuto, Rosa, Hagendoorn, Jeroen, and Borel Rinkes, Inne H.M.

Published
2023

33. Lutetium-177-PSMA bij gemetastaseerd prostaatcarcinoom

Author

Researchgr. Nucleaire Geneeskunde, Cancer, van Golen, Larissa W., Vogel, Wouter, Lam, Marnix G.E.H., Researchgr. Nucleaire Geneeskunde, Cancer, van Golen, Larissa W., Vogel, Wouter, and Lam, Marnix G.E.H.

Published
2023

35. Evaluating the Targeting of a Staphylococcus-aureus-Infected Implant with a Radiolabeled Antibody In Vivo

Author

ORT Research, MMB Research line 1, Infection & Immunity, Researchgr. Nucleaire Geneeskunde, Cancer, Radionuclide Apotheek, Translational Neuroscience, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Orthopaedie Opleiding, van Dijk, Bruce, Hooning van Duyvenbode, J. Fred F., de Vor, Lisanne, Nurmohamed, F. Ruben H.A., Lam, Marnix G.E.H., Poot, Alex J., Ramakers, Ruud M., Koustoulidou, Sofia, Beekman, Freek J., van Strijp, Jos, Rooijakkers, Suzan H.M., Dadachova, Ekaterina, Vogely, H. Charles, Weinans, Harrie, van der Wal, Bart C.H., ORT Research, MMB Research line 1, Infection & Immunity, Researchgr. Nucleaire Geneeskunde, Cancer, Radionuclide Apotheek, Translational Neuroscience, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Orthopaedie Opleiding, van Dijk, Bruce, Hooning van Duyvenbode, J. Fred F., de Vor, Lisanne, Nurmohamed, F. Ruben H.A., Lam, Marnix G.E.H., Poot, Alex J., Ramakers, Ruud M., Koustoulidou, Sofia, Beekman, Freek J., van Strijp, Jos, Rooijakkers, Suzan H.M., Dadachova, Ekaterina, Vogely, H. Charles, Weinans, Harrie, and van der Wal, Bart C.H.

Published
2023

36. PSMA-PET: aanwinst voor de prostaatkankerdiagnostiek

Author

Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, van der Sar, Esmée C.A., Lavalaye, Jules, Braat, Arthur J.A.T., de Klerk, John M.H., Lam, Marnix G.E.H., de Keizer, Bart, Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, van der Sar, Esmée C.A., Lavalaye, Jules, Braat, Arthur J.A.T., de Klerk, John M.H., Lam, Marnix G.E.H., and de Keizer, Bart

Published
2023

37. [18F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study

Author

Radionuclide Apotheek, Cancer, MS Radiologie, Fysica Radiologie, Onderzoek Beeld, Researchgr. Nucleaire Geneeskunde, Samim, Atia, Blom, Thomas, Poot, Alex J., Windhorst, Albert D., Fiocco, Marta, Tolboom, Nelleke, Braat, Arthur J.A.T., Viol, Sebastiaan L.Meyer, van Rooij, Rob, van Noesel, Max M., Lam, Marnix G.E.H., Tytgat, Godelieve A.M., de Keizer, Bart, Radionuclide Apotheek, Cancer, MS Radiologie, Fysica Radiologie, Onderzoek Beeld, Researchgr. Nucleaire Geneeskunde, Samim, Atia, Blom, Thomas, Poot, Alex J., Windhorst, Albert D., Fiocco, Marta, Tolboom, Nelleke, Braat, Arthur J.A.T., Viol, Sebastiaan L.Meyer, van Rooij, Rob, van Noesel, Max M., Lam, Marnix G.E.H., Tytgat, Godelieve A.M., and de Keizer, Bart

Published
2023

44. Improving the Diagnostic Performance of 18F-Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography in Prosthetic Heart Valve Endocarditis

Author

Swart, Laurens E., Gomes, Anna, Scholtens, Asbjørn M., Sinha, Bhanu, Tanis, Wilco, Lam, Marnix G.E.H., van der Vlugt, Maureen J., Streukens, Sebastian A.F., Aarntzen, Erik H.J.G., Bucerius, Jan, van Assen, Sander, Bleeker-Rovers, Chantal P., van Geel, Peter Paul, Krestin, Gabriel P., van Melle, Joost P., Roos-Hesselink, Jolien W., Slart, Riemer H.J.A., Glaudemans, Andor W.J.M., and Budde, Ricardo P.J.

Published
2018
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49. Inflammatory markers and long term hematotoxicity of holmium-166-radioembolization in liver-dominant metastatic neuroendocrine tumors after initial peptide receptor radionuclide therapy

Author

Ebbers, Sander C., Brabander, Tessa, Tesselaar, Margot E.T., Hofland, Johannes, Braat, Manon N.G.J.A., Wessels, Frank J., Barentsz, Maarten W., Lam, Marnix G.E.H., Braat, Arthur J.A.T., Ebbers, Sander C., Brabander, Tessa, Tesselaar, Margot E.T., Hofland, Johannes, Braat, Manon N.G.J.A., Wessels, Frank J., Barentsz, Maarten W., Lam, Marnix G.E.H., and Braat, Arthur J.A.T.

Abstract

Purpose: In patients with neuroendocrine tumor liver metastases, additional tumor reduction can be achieved by sequential treatment with [166Ho]-radioembolization after peptide receptor radionuclide therapy (PRRT). The aim of this study was to analyze hematotoxicity profiles, (i.e. lymphocyte and neutrophile toxicity) and the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and thrombocyte-to-lymphocyte ratio (TLR). Methods: All patients included in the prospective HEPAR PLuS study were included in this study. Blood testing was performed at baseline (before radioembolization) and at regular intervals during 1-year follow-up. Radiological response was assessed at 3, 6, 9, and 12 months according to RECIST 1.1. Logistic regression was used to analyze the prognostic value of NLR and TLR on response. Results: Thirty-one patients were included in the toxicity analysis; thirty were included in the response analysis. Three weeks after radioembolization, a significant decrease in lymphocyte count (mean change − 0.26 × 109/L) was observed. Ten patients (32.2%) experienced grade 3–4 lymphocyte toxicity. This normalized at 6 weeks and 3 months after treatment, while after 6 months a significant increase in lymphocyte count was observed. An increase in NLR and TLR at 3 weeks, compared to baseline, significantly predicted response at 3 months (AUC = 0.841 and AUC = 0.839, respectively) and at 6 months (AUC = 0.779 and AUC = 0.765). No significant relation with survival was found. Conclusions: Toxicity after sequential treatment with PRRT and [166Ho]-radioembolization is limited and temporary, while significant additional benefit can be expected. Change in NLR and TLR at 3-weeks follow-up may be valuable early predictors of response. Trial registration ClinicalTrials.gov, NCT02067988. Registered 20 February 2014, https://clinicaltrials.gov/ct2/show/record/NCT02067988.

Published
2022

50. Safety and Efficacy of 166Ho Radioembolization in Hepatocellular Carcinoma: The HEPAR Primary Study

Author

Cancer, Researchgr. Nucleaire Geneeskunde, MS MDL 1, Infection & Immunity, MS Radiologie, Other research (not in main researchprogram), Reinders, Margot T.M., van Erpecum, Karel J., Smits, Maarten L.J., Braat, Arthur J.A.T., Bruijne, Joep de, Bruijnen, Rutger, Sprengers, Dave, Man, Robert A.de, Vegt, Erik, IJzermans, Jan N.M., Moelker, Adriaan, Lam, Marnix G.E.H., Cancer, Researchgr. Nucleaire Geneeskunde, MS MDL 1, Infection & Immunity, MS Radiologie, Other research (not in main researchprogram), Reinders, Margot T.M., van Erpecum, Karel J., Smits, Maarten L.J., Braat, Arthur J.A.T., Bruijne, Joep de, Bruijnen, Rutger, Sprengers, Dave, Man, Robert A.de, Vegt, Erik, IJzermans, Jan N.M., Moelker, Adriaan, and Lam, Marnix G.E.H.

Published
2022

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