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841 results on '"Lam, Marnix G. E. H."'

1. Holmium-166 radioembolisation dosimetry in HCC

Author

Reinders, Margot T. M., Braat, Arthur J. A. T., van Erpecum, Karel J., de Bruijne, Joep, Bruijnen, Rutger C. G., Sprengers, Dave, de Man, Rob, Vegt, Erik, IJzermans, Jan N. M., Elias, Sjoerd G., Lam, Marnix G. E. H., and Smits, Maarten L. J.

Published
2025
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4. Dose finding study for unilobar radioembolization using holmium-166 microspheres to improve resectability in patients with HCC: the RALLY protocol

Author

Andel, Daan, Lam, Marnix G. E. H., de Bruijne, Joep, Smits, Maarten L. J., Braat, Arthur J. A. T., Moelker, Adriaan, Vegt, Erik, Ruiter, Simeon J. S., Noordzij, Walter, Grazi, Gianluca, Vallati, Giulio E., Bennink, Roel J., van Delden, Otto M., Kranenburg, Onno W., Ijzermans, Jan N. M., Nijkamp, Maarten W., Erdmann, Joris I., Sciuto, Rosa, Hagendoorn, Jeroen, and Borel Rinkes, Inne H. M.

Published
2023
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7. Interventieradiologie

Author

van Delden, Otto M., Schreuder, Sanne M., Bennink, Roel J., Lam, Marnix G. E. H., Maas, Mario, editor, Nusman, Charlotte, editor, Smithuis, Frank, editor, and Bennink, Roel, editor

Published
2023
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20. Radioembolization

Author

van Roekel, Caren, Braat, Arthur J. A. T., Smits, Maarten L. J., Bruijnen, Rutger C. G., de Keizer, Bart, Lam, Marnix G. E. H., Ahmadzadehfar, Hojjat, editor, Biersack, Hans-Jürgen, editor, Freeman, Leonard M., editor, and Zuckier, Lionel S., editor

Published
2020
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22. Additional holmium-166 radioembolisation after lutetium-177-dotatate in patients with neuroendocrine tumour liver metastases (HEPAR PLuS): a single-centre, single-arm, open-label, phase 2 study

Author

Braat, Arthur J A T, Bruijnen, Rutger C G, van Rooij, Rob, Braat, Manon N G J A, Wessels, Frank J, van Leeuwaarde, Rachel S, van Treijen, Mark J C, de Herder, Wouter W, Hofland, Johannes, Tesselaar, Margot E T, de Jong, Hugo W A M, and Lam, Marnix G E H

Published
2020
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24. Holmium-166 radioembolisation dosimetry in HCC

Author

Reinders, Margot T. M., Braat, Arthur J. A. T., van Erpecum, Karel J., de Bruijne, Joep, Bruijnen, Rutger C. G., Sprengers, Dave, de Man, Rob, Vegt, Erik, Ijzermans, Jan N. M., Elias, Sjoerd G., Lam, Marnix G. E. H., Smits, Maarten L. J., Reinders, Margot T. M., Braat, Arthur J. A. T., van Erpecum, Karel J., de Bruijne, Joep, Bruijnen, Rutger C. G., Sprengers, Dave, de Man, Rob, Vegt, Erik, Ijzermans, Jan N. M., Elias, Sjoerd G., Lam, Marnix G. E. H., and Smits, Maarten L. J.

Abstract

PurposeTo evaluate dosimetry, dose-response and dose-toxicity relationships for holmium-166 (166Ho) radioembolisation in patients with hepatocellular carcinoma (HCC).MethodsThirty-one patients with hepatocellular carcinoma were included in the HEPAR Primary study (NCT03379844, registered on December 20th, 2017) and underwent 166Ho-microspheres radioembolisation. Linear mixed models assessed the association between tumour absorbed doses and response based on mRECIST both on tumour and patient level. Preliminary tumour absorbed dose thresholds were estimated based on predictive value. Linear regression models assessed the association between non-tumour absorbed dose and Common Terminology Criteria for Adverse Events version 4.03.ResultsMedian tumour absorbed dose (tumour level) was 95.5 Gy (range 44-332 Gy). Median non-tumour absorbed dose based on whole liver volume was 19 Gy (range 3 - 48 Gy) and based on target liver volume was 30 Gy (range 13 - 54 Gy). There was a significant association between non-tumour absorbed dose and toxicity. Tumours with partial response/complete response (PR/CR, responders) received a 41% higher absorbed dose than tumours with progressive disease/stable disease (PD/SD, non-responders) (95%CI: 2%-93%, p = 0.04). A predictive value of 90% for tumour response was observed at a tumour absorbed dose threshold of 155 Gy, 100% predictive value was achieved at 184.5 Gy.ConclusionThis study confirms a positive relationship between tumour absorbed dose and response and between non-tumour absorbed dose and toxicity. Dose thresholds found in this study can serve as a basis for personalized dosimetry in HCC patients treated with 166Ho-microspheres.

Published
2024

26. Lung Mean Dose Prediction in Transarterial Radioembolization (TARE): Superiority of [ 166Ho]-Scout Over [ 99mTc]MAA in a Prospective Cohort Study

Author

Researchgr. Nucleaire Geneeskunde, MS Radiologie, Cancer, Fysica Radiologie, Other research (not in main researchprogram), MS Radiotherapie, Brain, Wagemans, Martijn E H M, Braat, Arthur J A T, van Rooij, Rob, Smits, Maarten L J, Bruijnen, Rutger C G, Prince, Jip F, Bol, Guus M, de Jong, Hugo W A M, Lam, Marnix G E H, Researchgr. Nucleaire Geneeskunde, MS Radiologie, Cancer, Fysica Radiologie, Other research (not in main researchprogram), MS Radiotherapie, Brain, Wagemans, Martijn E H M, Braat, Arthur J A T, van Rooij, Rob, Smits, Maarten L J, Bruijnen, Rutger C G, Prince, Jip F, Bol, Guus M, de Jong, Hugo W A M, and Lam, Marnix G E H

Published
2024

27. Comparison of 3 Different Therapeutic Particles in Radioembolization of Locally Advanced Intrahepatic Cholangiocarcinoma

Author

Researchgr. Nucleaire Geneeskunde, Cancer, Fysica Radiologie, Brain, MS Radiologie, Wagemans, Martijn E H M, Kunnen, Britt, Stella, Martina, van Rooij, Rob, Lam, Marnix G E H, de Jong, Hugo W A M, Braat, Arthur J A T, Researchgr. Nucleaire Geneeskunde, Cancer, Fysica Radiologie, Brain, MS Radiologie, Wagemans, Martijn E H M, Kunnen, Britt, Stella, Martina, van Rooij, Rob, Lam, Marnix G E H, de Jong, Hugo W A M, and Braat, Arthur J A T

Published
2024

28. Extrahepatic perfusion and incomplete hepatic perfusion after hepatic arterial infusion pump implantation:incidence and clinical implications

Author

Filipe, Wills F, Buisman, Florian E, Franssen, Stijn, Krul, Myrtle F, Grünhagen, Dirk J, Bennink, Roel J, Bolhuis, Karen, Bruijnen, Rutger C G, Buffart, Tineke E, Burgmans, Mark C, van Delden, Otto M, Doornebosch, Pascal G, Gobardhan, Paul D, Graven, Laura, de Groot, Jan Willem B, Grootscholten, Cecile, Hagendoorn, Jeroen, Harmsen, Paul, Homs, Marjolein Y V, Klompenhouwer, Elizabeth G, Kok, Niels F M, Lam, Marnix G E H, Loosveld, Olaf J L, Meier, Mark A J, Mieog, J Sven D, Oostdijk, Ad H J, Outmani, Loubna, Patijn, Gijs A, Pool, Stefan, Rietbergen, Daphne D D, Roodhart, Jeanine M L, Speetjens, Frank M, Swijnenburg, Rutger Jan, Versleijen, Michelle W J, Verhoef, Cornelis, Kuhlmann, Koert F D, Moelker, Adriaan, Groot Koerkamp, Bas, Filipe, Wills F, Buisman, Florian E, Franssen, Stijn, Krul, Myrtle F, Grünhagen, Dirk J, Bennink, Roel J, Bolhuis, Karen, Bruijnen, Rutger C G, Buffart, Tineke E, Burgmans, Mark C, van Delden, Otto M, Doornebosch, Pascal G, Gobardhan, Paul D, Graven, Laura, de Groot, Jan Willem B, Grootscholten, Cecile, Hagendoorn, Jeroen, Harmsen, Paul, Homs, Marjolein Y V, Klompenhouwer, Elizabeth G, Kok, Niels F M, Lam, Marnix G E H, Loosveld, Olaf J L, Meier, Mark A J, Mieog, J Sven D, Oostdijk, Ad H J, Outmani, Loubna, Patijn, Gijs A, Pool, Stefan, Rietbergen, Daphne D D, Roodhart, Jeanine M L, Speetjens, Frank M, Swijnenburg, Rutger Jan, Versleijen, Michelle W J, Verhoef, Cornelis, Kuhlmann, Koert F D, Moelker, Adriaan, and Groot Koerkamp, Bas

Abstract

INTRODUCTION: This study investigates the incidence of extrahepatic perfusion and incomplete hepatic perfusion at intraoperative methylene blue testing and on postoperative nuclear imaging in patients undergoing hepatic arterial infusion pump (HAIP) chemotherapy.METHODS:The first 150 consecutive patients who underwent pump implantation in the Netherlands were included. All patients underwent surgical pump implantation with the catheter in the gastroduodenal artery. All patients underwent intraoperative methylene blue testing and postoperative nuclear imaging ( 99mTc-Macroaggregated albumin SPECT/CT) to determine perfusion via the pump. RESULTS: Patients were included between January-2018 and December-2021 across eight centers. During methylene blue testing, 29.3% had extrahepatic perfusion, all successfully managed intraoperatively. On nuclear imaging, no clinically relevant extrahepatic perfusion was detected (0%, 95%CI: 0.0-2.5%). During methylene blue testing, 2.0% had unresolved incomplete hepatic perfusion. On postoperative nuclear imaging, 8.1% had incomplete hepatic perfusion, leading to embolization in only 1.3%.CONCLUSION: Methylene blue testing during pump placement for intra-arterial chemotherapy identified extrahepatic perfusion in 29.3% of patients, but could be resolved intraoperatively in all patients. Postoperative nuclear imaging found no clinically relevant extrahepatic perfusion and led to embolization in only 1.3% of patients. The role of routine nuclear imaging after HAIP implantation should be studied in a larger cohort.

Published
2024

34. Prophylactic Medication during Radioembolization in Metastatic Liver Disease: Is It Really Necessary? A Retrospective Cohort Study and Systematic Review of the Literature

Author

Braat, Manon N. G. J. A., primary, Ebbers, Sander C., additional, Alsultan, Ahmed A., additional, Neek, Atal O., additional, Bruijnen, Rutger C. G., additional, Smits, Maarten L. J., additional, de Bruijne, Joep, additional, Lam, Marnix G. E. H., additional, and Braat, Arthur J. A. T., additional

Published
2023
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40. Lung Mean Dose Prediction in Transarterial Radioembolization (TARE): Superiority of [166Ho]-Scout Over [99mTc]MAA in a Prospective Cohort Study.

Author

Wagemans, Martijn E. H. M., Braat, Arthur J. A. T., van Rooij, Rob, Smits, Maarten L. J., Bruijnen, Rutger C. G., Prince, Jip F., Bol, Guus M., de Jong, Hugo W. A. M., and Lam, Marnix G. E. H.

Subjects
RADIOEMBOLIZATION, LONGITUDINAL method, RADIATION pneumonitis, LUNGS, COHORT analysis
Abstract

Purpose: Radiation pneumonitis is a serious complication of radioembolization. In holmium-166 ([166Ho]) radioembolization, the lung mean dose (LMD) can be estimated (eLMD) using a scout dose with either technetium-99 m-macroaggregated albumin ([99mTc]MAA) or [166Ho]-microspheres. The accuracy of eLMD based on [99mTc]MAA (eLMDMAA) was compared to eLMD based on [166Ho]-scout dose (eLMDHo-scout) in two prospective clinical studies. Materials and Methods: Patients were included if they received both scout doses ([99mTc]MAA and [166Ho]-scout), had a posttreatment [166Ho]-SPECT/CT (gold standard) and were scanned on the same hybrid SPECT/CT system. The correlation between eLMDMAA/eLMDHo-scout and LMDHo-treatment was assessed by Spearman's rank correlation coefficient (r). Wilcoxon signed rank test was used to analyze paired data. Results: Thirty-seven patients with unresectable liver metastases were included. During follow-up, none developed symptoms of radiation pneumonitis. Median eLMDMAA (1.53 Gy, range 0.09–21.33 Gy) was significantly higher than median LMDHo-treatment (0.00 Gy, range 0.00–1.20 Gy; p < 0.01). Median eLMDHo-scout (median 0.00 Gy, range 0.00–1.21 Gy) was not significantly different compared to LMDHo-treatment (p > 0.05). In all cases, eLMDMAA was higher than LMDHo-treatment (p < 0.01). While a significant correlation was found between eLMDHo-scout and LMDHo-treatment (r = 0.43, p < 0.01), there was no correlation between eLMDMAA and LMDHo-treatment (r = 0.02, p = 0.90). Conclusion: [166Ho]-scout dose is superior in predicting LMD over [99mTc]MAA, in [166Ho]-radioembolization. Consequently, [166Ho]-scout may limit unnecessary patient exclusions and avoid unnecessary therapeutic activity reductions in patients eligible for radioembolization. Trail registration: NCT01031784, registered December 2009. NCT01612325, registered June 2012. [ABSTRACT FROM AUTHOR]

Published
2024
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47. Prophylactic Medication during Radioembolization in Metastatic Liver Disease: Is It Really Necessary? A Retrospective Cohort Study and Systematic Review of the Literature

Author

Cancer, MS Radiologie, Researchgr. Nucleaire Geneeskunde, Other research (not in main researchprogram), MS MDL 1, Braat, Manon N G J A, Ebbers, Sander C, Alsultan, Ahmed A, Neek, Atal O, Bruijnen, Rutger C G, Smits, Maarten L J, de Bruijne, Joep, Lam, Marnix G E H, Braat, Arthur J A T, Cancer, MS Radiologie, Researchgr. Nucleaire Geneeskunde, Other research (not in main researchprogram), MS MDL 1, Braat, Manon N G J A, Ebbers, Sander C, Alsultan, Ahmed A, Neek, Atal O, Bruijnen, Rutger C G, Smits, Maarten L J, de Bruijne, Joep, Lam, Marnix G E H, and Braat, Arthur J A T

Published
2023

48. Tolerability of concurrent external beam radiotherapy and [ 177Lu]Lu-PSMA-617 for node-positive prostate cancer in treatment naïve patients, phase I study (PROQURE-I trial).

Author

Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, MS Radiotherapie, van der Sar, Esmée C A, Braat, Arthur J A T, van der Voort-van Zyp, Jochem R N, van der Veen, Betty S, van Leeuwen, Pim J, de Vries-Huizing, Daphne M V, Hendrikx, Jeroen M A, Lam, Marnix G E H, Vogel, Wouter V, Cancer, Researchgr. Nucleaire Geneeskunde, MS Radiologie, MS Radiotherapie, van der Sar, Esmée C A, Braat, Arthur J A T, van der Voort-van Zyp, Jochem R N, van der Veen, Betty S, van Leeuwen, Pim J, de Vries-Huizing, Daphne M V, Hendrikx, Jeroen M A, Lam, Marnix G E H, and Vogel, Wouter V

Published
2023

49. Automatic healthy liver segmentation for holmium-166 radioembolization dosimetry

Author

Cancer, Researchgr. Nucleaire Geneeskunde, Fysica Radiologie, Brain, MS Radiologie, Stella, Martina, van Rooij, Rob, Lam, Marnix G E H, de Jong, Hugo W A M, Braat, Arthur J A T, Cancer, Researchgr. Nucleaire Geneeskunde, Fysica Radiologie, Brain, MS Radiologie, Stella, Martina, van Rooij, Rob, Lam, Marnix G E H, de Jong, Hugo W A M, and Braat, Arthur J A T

Published
2023

50. Impact of uptake time on image quality of [68 Ga]Ga-PSMA-11 PET/CT

Author

Researchgr. Nucleaire Geneeskunde, Cancer, MS Radiologie, Fysica Radiologie, Brain, van der Sar, Esmée C A, Viol, Sebastiaan L Meyer, Braat, Arthur J A T, van Rooij, Rob, Lam, Marnix G E H, de Jong, Hugo W A M, de Keizer, Bart, Researchgr. Nucleaire Geneeskunde, Cancer, MS Radiologie, Fysica Radiologie, Brain, van der Sar, Esmée C A, Viol, Sebastiaan L Meyer, Braat, Arthur J A T, van Rooij, Rob, Lam, Marnix G E H, de Jong, Hugo W A M, and de Keizer, Bart

Published
2023

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