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9 results on '"Lam, M. G.E.H."'

1. Dose–effect relationships in neuroendocrine tumour liver metastases treated with [166Ho]-radioembolization

Author

Researchgr. Nucleaire Geneeskunde, Cancer, Arts-assistenten Radiologie, Fysica Radiologie, MS Radiologie, Other research (not in main researchprogram), Brain, Circulatory Health, Ramdhani, K., Beijer-Verduin, J., Ebbers, S. C., van Rooij, R., Smits, M. L.J., Bruijnen, R. C.G., de Jong, H. W.A.M., Lam, M. G.E.H., Braat, A. J.A.T., Researchgr. Nucleaire Geneeskunde, Cancer, Arts-assistenten Radiologie, Fysica Radiologie, MS Radiologie, Other research (not in main researchprogram), Brain, Circulatory Health, Ramdhani, K., Beijer-Verduin, J., Ebbers, S. C., van Rooij, R., Smits, M. L.J., Bruijnen, R. C.G., de Jong, H. W.A.M., Lam, M. G.E.H., and Braat, A. J.A.T.

Published
2024

2. Intra-arterial peptide-receptor radionuclide therapy for neuro-endocrine tumour liver metastases:an in-patient randomised controlled trial (LUTIA)

Author

Ebbers, S. C., Barentsz, M. W., de Vries-Huizing, D. M.V., Versleijen, M. W.J., Klompenhouwer, E. G., Tesselaar, M. E.T., Stokkel, M. P.M., Brabander, T., Hofland, J., Moelker, A., van Leeuwaarde, R. S., Smits, M. L.J., Braat, A. J.A.T., Lam, M. G.E.H., Ebbers, S. C., Barentsz, M. W., de Vries-Huizing, D. M.V., Versleijen, M. W.J., Klompenhouwer, E. G., Tesselaar, M. E.T., Stokkel, M. P.M., Brabander, T., Hofland, J., Moelker, A., van Leeuwaarde, R. S., Smits, M. L.J., Braat, A. J.A.T., and Lam, M. G.E.H.

Abstract

Purpose: Peptide receptor radionuclide therapy (PRRT) using [177Lu]Lu-DOTATATE has been shown to effectively prolong progression free survival in grade 1–2 gastroenteropancreatic neuroendocrine tumours (GEP-NET), but is less efficacious in patients with extensive liver metastases. The aim was to investigate whether tumour uptake in liver metastases can be enhanced by intra-arterial administration of [177Lu]Lu-DOTATATE into the hepatic artery, in order to improve tumour response without increasing toxicity. Methods: Twenty-seven patients with grade 1–2 GEP-NET, and bi-lobar liver metastases were randomized to receive intra-arterial PRRT in the left or right liver lobe for four consecutive cycles. The contralateral liver lobe and extrahepatic disease were treated via a “second-pass” effect and the contralateral lobe was used as the control lobe. Up to three metastases (> 3 cm) per liver lobe were identified as target lesions at baseline on contrast-enhanced CT. The primary endpoint was the tumour-to-non-tumour (T/N) uptake ratio on the 24 h post-treatment [177Lu]Lu-SPECT/CT after the first cycle. This was calculated for each target lesion in both lobes using the mean uptake. T/N ratios in both lobes were compared using paired-samples t-test. Findings: After the first cycle, a non-significant difference in T/N uptake ratio was observed: T/NIA = 17·4 vs. T/Ncontrol = 16·2 (p = 0·299). The mean increase in T/N was 17% (1·17; 95% CI [1·00; 1·37]). Of all patients, 67% (18/27) showed any increase in T/N ratio after the first cycle. Conclusion: Intra-arterial [177Lu]Lu-DOTATATE is safe, but does not lead to a clinically significant increase in tumour uptake.

Published
2024

4. Challenges in Von Hippel–Lindau’s disease: PRRT in patients on hemodialysis

Author

Unit Opleiding Aios, MS Radiologie, MS Endocriene Oncologie, Cancer, Ayub, N., Braat, A. J.A.T., Timmers, H. J.L.M., Lam, M. G.E.H., van Leeuwaarde, R. S., Unit Opleiding Aios, MS Radiologie, MS Endocriene Oncologie, Cancer, Ayub, N., Braat, A. J.A.T., Timmers, H. J.L.M., Lam, M. G.E.H., and van Leeuwaarde, R. S.

Published
2022

5. Treating infections with ionizing radiation: a historical perspective and emerging techniques

Author

van Dijk, B., Lemans, J. V.C., Hoogendoorn, R. M., Dadachova, E., de Klerk, J. M.H., Vogely, H. C., Weinans, H.H., Lam, M. G.E.H., and van der Wal, B. C.H.

Subjects
Inflammation, Radiation, Radiotherapy, Anti-inflammation, Biofilm, X-rays, Orthopaedic infection, Periprosthetic joint infection, Radioimmunotherapy, Infection
Abstract

BACKGROUND: Widespread use and misuse of antibiotics have led to a dramatic increase in the emergence of antibiotic resistant bacteria, while the discovery and development of new antibiotics is declining. This has made certain implant-associated infections such as periprosthetic joint infections, where a biofilm is formed, very difficult to treat. Alternative treatment modalities are needed to treat these types of infections in the future. One candidate that has been used extensively in the past, is the use of ionizing radiation. This review aims to provide a historical overview and future perspective of radiation therapy in infectious diseases with a focus on orthopedic infections. METHODS: A systematic search strategy was designed to select studies that used radiation as treatment for bacterial or fungal infections. A total of 216 potentially relevant full-text publications were independently reviewed, of which 182 focused on external radiation and 34 on internal radiation. Due to the large number of studies, several topics were chosen. The main advantages, disadvantages, limitations, and implications of radiation treatment for infections were discussed. RESULTS: In the pre-antibiotic era, high mortality rates were seen in different infections such as pneumonia, gas gangrene and otitis media. In some cases, external radiation therapy decreased the mortality significantly but long-term follow-up of the patients was often not performed so long term radiation effects, as well as potential increased risk of malignancies could not be investigated. Internal radiation using alpha and beta emitting radionuclides show great promise in treating fungal and bacterial infections when combined with selective targeting through antibodies, thus minimizing possible collateral damage to healthy tissue. CONCLUSION: The novel prospects of radiation treatment strategies against planktonic and biofilm-related microbial infections seem feasible and are worth investigating further. However, potential risks involving radiation treatment must be considered in each individual patient.

Published
2020

6. Treating infections with ionizing radiation: a historical perspective and emerging techniques

Author

van Dijk, B. (author), Lemans, J. V.C. (author), Hoogendoorn, R. M. (author), Dadachova, E. (author), de Klerk, J. M.H. (author), Vogely, H. C. (author), Weinans, H.H. (author), Lam, M. G.E.H. (author), van der Wal, B. C.H. (author), van Dijk, B. (author), Lemans, J. V.C. (author), Hoogendoorn, R. M. (author), Dadachova, E. (author), de Klerk, J. M.H. (author), Vogely, H. C. (author), Weinans, H.H. (author), Lam, M. G.E.H. (author), and van der Wal, B. C.H. (author)

Abstract

BACKGROUND: Widespread use and misuse of antibiotics have led to a dramatic increase in the emergence of antibiotic resistant bacteria, while the discovery and development of new antibiotics is declining. This has made certain implant-associated infections such as periprosthetic joint infections, where a biofilm is formed, very difficult to treat. Alternative treatment modalities are needed to treat these types of infections in the future. One candidate that has been used extensively in the past, is the use of ionizing radiation. This review aims to provide a historical overview and future perspective of radiation therapy in infectious diseases with a focus on orthopedic infections. METHODS: A systematic search strategy was designed to select studies that used radiation as treatment for bacterial or fungal infections. A total of 216 potentially relevant full-text publications were independently reviewed, of which 182 focused on external radiation and 34 on internal radiation. Due to the large number of studies, several topics were chosen. The main advantages, disadvantages, limitations, and implications of radiation treatment for infections were discussed. RESULTS: In the pre-antibiotic era, high mortality rates were seen in different infections such as pneumonia, gas gangrene and otitis media. In some cases, external radiation therapy decreased the mortality significantly but long-term follow-up of the patients was often not performed so long term radiation effects, as well as potential increased risk of malignancies could not be investigated. Internal radiation using alpha and beta emitting radionuclides show great promise in treating fungal and bacterial infections when combined with selective targeting through antibodies, thus minimizing possible collateral damage to healthy tissue. CONCLUSION: The novel prospects of radiation treatment strategies against planktonic and biofilm-related microbial infections seem feasible and are worth investigating further. Ho, Biomaterials & Tissue Biomechanics

Published
2020
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8. Preoperative image-guided identification of response to neoadjuvant chemoradiotherapy in esophageal cancer (PRIDE): A multicenter observational study

Author

Borggreve, A. S., Mook, S., Verheij, M., Mul, V. E.M., Bergman, J. J., Bartels-Rutten, A., Ter Beek, L. C., Beets-Tan, R. G.H., Bennink, R. J., Van Berge Henegouwen, M. I., Brosens, L. A.A., Defize, I. L., Van Dieren, J. M., Dijkstra, H., Van Hillegersberg, R., Hulshof, M. C., Van Laarhoven, H. W.M., Lam, M. G.E.H., Van Lier, A. L.H.M.W., Muijs, C. T., Nagengast, W. B., Nederveen, A. J., Noordzij, W., Plukker, J. T.M., Van Rossum, P. S.N., Ruurda, J. P., Van Sandick, J. W., Weusten, B. L.A.M., Voncken, F. E.M., Yakar, D., Meijer, G. J., Aleman, B. M.P., Borra, R. J.H., Van Etten, B., Gisbertz, S. S., Goense, L., Haj Mohammad, N., Hartemink, K. J., Kappert, P., Kats-Ugurlu, G., Kodach, L. L., Korteweg, T., Krishnadath, K. K., Langendijk, J. A., De Leng, W. W.J., Meijer, S. L., Potze, J. H., Stoker, J., Vegt, E., Verkooijen, H. M., Vollenbrock, S. E., Wessels, F., Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Gastroenterology and Hepatology, AGEM - Re-generation and cancer of the digestive system, Nuclear Medicine, Radiology and Nuclear Medicine, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery, CCA - Imaging and biomarkers, Radiotherapy, Oncology, ACS - Diabetes & metabolism, AMS - Restoration & Development, ANS - Brain Imaging, Pathology, and AGEM - Digestive immunity

Subjects
Cancer Research, Esophageal Neoplasms, PREDICTION, SURGERY, medicine.medical_treatment, Esophageal cancer, FREE DNA, Study Protocol, 0302 clinical medicine, Positron Emission Tomography Computed Tomography, Pathologic complete response, PATHOLOGICAL COMPLETE RESPONSE, FDG-PET, medicine.diagnostic_test, Image-guided, Chemoradiotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Primary tumor, Neoadjuvant Therapy, Neoadjuvant chemoradiotherapy, medicine.anatomical_structure, Fine-needle aspiration, Treatment Outcome, Oncology, Positron emission tomography, Esophagectomy, 030220 oncology & carcinogenesis, GASTROESOPHAGEAL CANCER, Adenocarcinoma, 030211 gastroenterology & hepatology, Radiology, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], MRI, medicine.medical_specialty, DCE-MRI, PET-CT, lcsh:RC254-282, 03 medical and health sciences, POSITRON-EMISSION-TOMOGRAPHY, DW-MRI, Preoperative Care, medicine, Genetics, Humans, Esophagus, JUNCTIONAL CANCER, business.industry, PERIOPERATIVE CHEMOTHERAPY, ctDNA, medicine.disease, CIRCULATING TUMOR-CELLS, business, Follow-Up Studies
Abstract

Contains fulltext : 200332.pdf (Publisher’s version ) (Open Access) BACKGROUND: Nearly one third of patients undergoing neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer have a pathologic complete response (pCR) of the primary tumor upon histopathological evaluation of the resection specimen. The primary aim of this study is to develop a model that predicts the probability of pCR to nCRT in esophageal cancer, based on diffusion-weighted magnetic resonance imaging (DW-MRI), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and (18)F-fluorodeoxyglucose positron emission tomography with computed tomography ((18)F-FDG PET-CT). Accurate response prediction could lead to a patient-tailored approach with omission of surgery in the future in case of predicted pCR or additional neoadjuvant treatment in case of non-pCR. METHODS: The PRIDE study is a prospective, single arm, observational multicenter study designed to develop a multimodal prediction model for histopathological response to nCRT for esophageal cancer. A total of 200 patients with locally advanced esophageal cancer - of which at least 130 patients with adenocarcinoma and at least 61 patients with squamous cell carcinoma - scheduled to receive nCRT followed by esophagectomy will be included. The primary modalities to be incorporated in the prediction model are quantitative parameters derived from MRI and (18)F-FDG PET-CT scans, which will be acquired at fixed intervals before, during and after nCRT. Secondary modalities include blood samples for analysis of the presence of circulating tumor DNA (ctDNA) at 3 time-points (before, during and after nCRT), and an endoscopy with (random) bite-on-bite biopsies of the primary tumor site and other suspected lesions in the esophagus as well as an endoscopic ultrasonography (EUS) with fine needle aspiration of suspected lymph nodes after finishing nCRT. The main study endpoint is the performance of the model for pCR prediction. Secondary endpoints include progression-free and overall survival. DISCUSSION: If the multimodal PRIDE concept provides high predictive performance for pCR, the results of this study will play an important role in accurate identification of esophageal cancer patients with a pCR to nCRT. These patients might benefit from a patient-tailored approach with omission of surgery in the future. Vice versa, patients with non-pCR might benefit from additional neoadjuvant treatment, or ineffective therapy could be stopped. TRIAL REGISTRATION: The article reports on a health care intervention on human participants and was prospectively registered on March 22, 2018 under ClinicalTrials.gov Identifier: NCT03474341 .

Published
2018

9. Preoperative image-guided identification of response to neoadjuvant chemoradiotherapy in esophageal cancer (PRIDE): A multicenter observational study

Author

Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Pathologie Pathologen staf, Fysica Radiotherapie Research, Divisie Beeld & Oncologie, Researchgr. Nucleaire Geneeskunde, Arts-assistenten Radiotherapie, MS CGO, MS MDL 1, Klinische Fysica RT, Verpleegafdeling Hematologie, Unit D (laboranten rath), Trialbureau Beeld, Epi Kanker Team A, Circulatory Health, JC onderzoeksprogramma Kanker, MS Radiologie, Borggreve, A. S., Mook, S., Verheij, M., Mul, V. E.M., Bergman, J. J., Bartels-Rutten, A., Ter Beek, L. C., Beets-Tan, R. G.H., Bennink, R. J., Van Berge Henegouwen, M. I., Brosens, L. A.A., Defize, I. L., Van Dieren, J. M., Dijkstra, H., Van Hillegersberg, R., Hulshof, M. C., Van Laarhoven, H. W.M., Lam, M. G.E.H., Van Lier, A. L.H.M.W., Muijs, C. T., Nagengast, W. B., Nederveen, A. J., Noordzij, W., Plukker, J. T.M., Van Rossum, P. S.N., Ruurda, J. P., Van Sandick, J. W., Weusten, B. L.A.M., Voncken, F. E.M., Yakar, D., Meijer, G. J., Aleman, B. M.P., Borra, R. J.H., Van Etten, B., Gisbertz, S. S., Goense, L., Haj Mohammad, N., Hartemink, K. J., Kappert, P., Kats-Ugurlu, G., Kodach, L. L., Korteweg, T., Krishnadath, K. K., Langendijk, J. A., De Leng, W. W.J., Meijer, S. L., Potze, J. H., Stoker, J., Vegt, E., Verkooijen, H. M., Vollenbrock, S. E., Wessels, F., Onderzoek Radiotherapie, MS Radiotherapie, Cancer, Pathologie Pathologen staf, Fysica Radiotherapie Research, Divisie Beeld & Oncologie, Researchgr. Nucleaire Geneeskunde, Arts-assistenten Radiotherapie, MS CGO, MS MDL 1, Klinische Fysica RT, Verpleegafdeling Hematologie, Unit D (laboranten rath), Trialbureau Beeld, Epi Kanker Team A, Circulatory Health, JC onderzoeksprogramma Kanker, MS Radiologie, Borggreve, A. S., Mook, S., Verheij, M., Mul, V. E.M., Bergman, J. J., Bartels-Rutten, A., Ter Beek, L. C., Beets-Tan, R. G.H., Bennink, R. J., Van Berge Henegouwen, M. I., Brosens, L. A.A., Defize, I. L., Van Dieren, J. M., Dijkstra, H., Van Hillegersberg, R., Hulshof, M. C., Van Laarhoven, H. W.M., Lam, M. G.E.H., Van Lier, A. L.H.M.W., Muijs, C. T., Nagengast, W. B., Nederveen, A. J., Noordzij, W., Plukker, J. T.M., Van Rossum, P. S.N., Ruurda, J. P., Van Sandick, J. W., Weusten, B. L.A.M., Voncken, F. E.M., Yakar, D., Meijer, G. J., Aleman, B. M.P., Borra, R. J.H., Van Etten, B., Gisbertz, S. S., Goense, L., Haj Mohammad, N., Hartemink, K. J., Kappert, P., Kats-Ugurlu, G., Kodach, L. L., Korteweg, T., Krishnadath, K. K., Langendijk, J. A., De Leng, W. W.J., Meijer, S. L., Potze, J. H., Stoker, J., Vegt, E., Verkooijen, H. M., Vollenbrock, S. E., and Wessels, F.

Published
2018

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