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3. Eligibility of Asian and European registry patients for phase III trials in heart failure with reduced ejection fraction.

Author

Lim, Yvonne Mei Fong, Asselbergs, Folkert W., Bagheri, Ayoub, Denaxas, Spiros, Tay, Wan Ting, Voors, Adriaan, Lam, Carolyn Su Ping, Koudstaal, Stefan, Grobbee, Diederick E., and Vaartjes, Ilonca

Subjects
CLINICAL trials, HEART valve diseases, NATURAL language processing, ACUTE coronary syndrome, HEART failure patients, CLINICAL trial registries
Abstract

Aims: Traditional approaches to designing clinical trials for heart failure (HF) have historically relied on expertise and past practices. However, the evolving landscape of healthcare, marked by the advent of novel data science applications and increased data availability, offers a compelling opportunity to transition towards a data‐driven paradigm in trial design. This research aims to evaluate the scope and determinants of disparities between clinical trials and registries by leveraging natural language processing for the analysis of trial eligibility criteria. The findings contribute to the establishment of a robust design framework for guiding future HF trials. Methods and results: Interventional phase III trials registered for HF on ClinicalTrials.gov as of the end of 2021 were identified. Natural language processing was used to extract and structure the eligibility criteria for quantitative analysis. The most common criteria for HF with reduced ejection fraction (HFrEF) were applied to estimate patient eligibility as a proportion of registry patients in the ASIAN‐HF (N = 4868) and BIOSTAT‐CHF registries (N = 2545). Of the 375 phase III trials for HF, 163 HFrEF trials were identified. In these trials, the most frequently encountered inclusion criteria were New York Heart Association (NYHA) functional class (69%), worsening HF (23%), and natriuretic peptides (18%), whereas the most frequent comorbidity‐based exclusion criteria were acute coronary syndrome (64%), renal disease (55%), and valvular heart disease (47%). On average, 20% of registry patients were eligible for HFrEF trials. Eligibility distributions did not differ (P = 0.18) between Asian [median eligibility 0.20, interquartile range (IQR) 0.08–0.43] and European registry populations (median 0.17, IQR 0.06–0.39). With time, HFrEF trials became more restrictive, where patient eligibility declined from 0.40 in 1985–2005 to 0.19 in 2016–2022 (P = 0.03). When frequency among trials is taken into consideration, the eligibility criteria that were most restrictive were prior myocardial infarction, NYHA class, age, and prior HF hospitalization. Conclusions: Based on 14 trial criteria, only one‐fifth of registry patients were eligible for phase III HFrEF trials. Overall eligibility rates did not differ between the Asian and European patient cohorts. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore

Author

Ackers-Johnson, Matthew Andrew, Aliwarga, Edita, Ban, Kenneth Hon Kim, Bertrand, Denis, Chambers, John C., Chan, Dana Leng Hui, Chan, Cheryl Xue Li, Chee, Miao Li, Chee, Miao Ling, Chen, Pauline, Chen, Yunxin, Chew, Elaine Guo Yan, Chew, Wen Jie, Chiam, Lynn Hui Yun, Chong, Jenny Pek Ching, Chua, Ivan, Cook, Stuart A., Dai, Wei, Dorajoo, Rajkumar, Foo, Chuan-Sheng, Goh, Rick Siow Mong, Hillmer, Axel M., Irwan, Ishak D., Jaufeerally, Fazlur, Javed, Asif, Jeyakani, Justin, Koh, John Tat Hung, Koh, Jia Yu, Krishnaswamy, Pavitra, Kuan, Jyn Ling, Kumari, Neelam, Lee, Ai Shan, Lee, Seow Eng, Lee, Sheldon, Lee, Yen Ling, Leong, See Ting, Li, Zheng, Li, Peter Yiqing, Liew, Jun Xian, Liew, Oi Wah, Lim, Su Chi, Lim, Weng Khong, Lim, Chia Wei, Lim, Tingsen Benson, Lim, Choon Kiat, Loh, Seet Yoong, Lok, Au Wing, Chin, Calvin W.L., Majithia, Shivani, Maurer-Stroh, Sebastian, Meah, Wee Yang, Mok, Shi Qi, Nargarajan, Niranjan, Ng, Pauline, Ng, Sarah B., Ng, Zhenyuan, Ng, Jessica Yan Xia, Ng, Ebonne, Ng, Shi Ling, Nusinovici, Simon, Ong, Chin Thing, Pan, Bangfen, Pedergnana, Vincent, Poh, Stanley, Prabhakar, Shyam, Prakash, Kumar M., Quek, Ivy, Sabanayagam, Charumathi, See, Wei Qiang, Sia, Yee Yen, Sim, Xueling, Sim, Wey Cheng, So, Jimmy, Soon, Dinna K.N., Tai, E. Shyong, Tan, Nicholas Y., Tan, Louis C.S., Tan, Hong Chang, Tan, Wilson Lek Wen, Tandiono, Moses, Tay, Amanda, Thakur, Sahil, Tham, Yih Chung, Tiang, Zenia, Toh, Grace Li-Xian, Tsai, Pi Kuang, Veeravalli, Lavanya, Verma, Chandra S., Wang, Ling, Wang, Min Rui, Wong, Wing-Cheong, Xie, Zhicheng, Yeo, Khung Keong, Zhang, Liang, Zhai, Weiwei, Zhao, Yi, Wu, Degang, Dou, Jinzhuang, Chai, Xiaoran, Bellis, Claire, Wilm, Andreas, Shih, Chih Chuan, Soon, Wendy Wei Jia, Bertin, Nicolas, Lin, Clarabelle Bitong, Khor, Chiea Chuen, DeGiorgio, Michael, Cheng, Shanshan, Bao, Li, Karnani, Neerja, Hwang, William Ying Khee, Davila, Sonia, Tan, Patrick, Shabbir, Asim, Moh, Angela, Tan, Eng-King, Foo, Jia Nee, Goh, Liuh Ling, Leong, Khai Pang, Foo, Roger S.Y., Lam, Carolyn Su Ping, Richards, Arthur Mark, Cheng, Ching-Yu, Aung, Tin, Wong, Tien Yin, Ng, Huck Hui, Liu, Jianjun, and Wang, Chaolong

Published
2019
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7. Clinical implications of the universal definition for the prevention and treatment of heart failure

Author

Chandramouli, Chanchal, Stewart, Simon, Almahmeed, Wael, and Lam, Carolyn Su Ping

Subjects
Heart Failure, EUROPEAN ASSOCIATION, 2013 ACCF/AHA GUIDELINE, symptoms and signs, universal definition of heart failure, NATRIURETIC PEPTIDE, General Medicine, HFrEF, AMERICAN-COLLEGE, HFpEF, clinical syndrome, stakeholders, CARDIAC STRUCTURE, PRESERVED EJECTION FRACTION, NT-proBNP, MANAGEMENT, Humans, ASSOCIATION TASK-FORCE, RISK-ASSESSMENT, Cardiology and Cardiovascular Medicine, CHAMBER QUANTIFICATION, Forecasting
Abstract

The diagnosis of heart failure (HF) primarily relies on signs and symptoms that are neither sensitive nor specific. This impedes timely diagnosis and delays effective therapies or interventions, despite the availability of several evidence‐based treatments for HF. Through monumental collaborative efforts from representatives of HF societies worldwide, the universal definition of HF was published in 2021, to provide the necessary standardized framework required for clinical management, clinical trials, and research. This review elaborates the key concepts of the new universal definition of HF, highlighting the key merits and potential avenues, which can be nuanced further in future iterations. We also discuss the key implications of the universal definition document from the perspectives of various stakeholders within the healthcare framework, including patients, care providers, system/payers and policymakers.

Published
2022
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8. Empagliflozin in Heart Failure with a Preserved Ejection Fraction

Author

Anker, Stefan D., primary, Butler, Javed, additional, Filippatos, Gerasimos, additional, Ferreira, João P., additional, Bocchi, Edimar, additional, Böhm, Michael, additional, Brunner–La Rocca, Hans-Peter, additional, Choi, Dong-Ju, additional, Chopra, Vijay, additional, Chuquiure-Valenzuela, Eduardo, additional, Giannetti, Nadia, additional, Gomez-Mesa, Juan Esteban, additional, Janssens, Stefan, additional, Januzzi, James L., additional, Gonzalez-Juanatey, Jose R., additional, Merkely, Bela, additional, Nicholls, Stephen J., additional, Perrone, Sergio V., additional, Piña, Ileana L., additional, Ponikowski, Piotr, additional, Senni, Michele, additional, Sim, David, additional, Spinar, Jindrich, additional, Squire, Iain, additional, Taddei, Stefano, additional, Tsutsui, Hiroyuki, additional, Verma, Subodh, additional, Vinereanu, Dragos, additional, Zhang, Jian, additional, Carson, Peter, additional, Lam, Carolyn Su Ping, additional, Marx, Nikolaus, additional, Zeller, Cordula, additional, Sattar, Naveed, additional, Jamal, Waheed, additional, Schnaidt, Sven, additional, Schnee, Janet M., additional, Brueckmann, Martina, additional, Pocock, Stuart J., additional, Zannad, Faiez, additional, and Packer, Milton, additional

Published
2021
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9. Empagliflozin in Heart Failure with a Preserved Ejection Fraction

Author

Anker, Stefan D. Butler, Javed Filippatos, Gerasimos and Ferreira, Joao P. Bocchi, Edimar Boehm, Michael Brunner-La Rocca, Hans-Peter Choi, Dong-Ju Chopra, Vijay and Chuquiure-Valenzuela, Eduardo Giannetti, Nadia Gomez-Mesa, Juan Esteban Janssens, Stefan Januzzi, James L. and Gonzalez-Juanatey, Jose R. Merkely, Bela Nicholls, Stephen J. and Perrone, Sergio V. Pina, Ileana L. Ponikowski, Piotr and Senni, Michele Sim, David Spinar, Jindrich Squire, Iain and Taddei, Stefano Tsutsui, Hiroyuki Verma, Subodh Vinereanu, Dragos Zhang, Jian Carson, Peter Lam, Carolyn Su Ping and Marx, Nikolaus Zeller, Cordula Sattar, Naveed Jamal, Waheed and Schnaidt, Sven Schnee, Janet M. Brueckmann, Martina and Pocock, Stuart J. Zannad, Faiez Packer, Milton EMPEROR Preserved Trial

Abstract

BACKGROUND Sodium-glucose cotransporter 2 inhibitors reduce the risk of hospitalization for heart failure in patients with heart failure and a reduced ejection fraction, but their effects in patients with heart failure and a preserved ejection fraction are uncertain. METHODS In this double-blind trial, we randomly assigned 5988 patients with class II-IV heart failure and an ejection fraction of more than 40% to receive empagliflozin (10 mg once daily) or placebo, in addition to usual therapy. The primary outcome was a composite of cardiovascular death or hospitalization for heart failure. RESULTS Over a median of 26.2 months, a primary outcome event occurred in 415 of 2997 patients (13.8%) in the empagliflozin group and in 511 of 2991 patients (17.1%) in the placebo group (hazard ratio, 0.79; 95% confidence interval [CI], 0.69 to 0.90; P

Published
2021

10. Socioeconomic Status and Outcomes in Heart Failure With Reduced Ejection Fraction From Asia

Author

Teng, Tiew-Hwa K., primary, Tay, Wan Ting, additional, Richards, Arthur Mark, additional, Chew, Timothy Shi Ming, additional, Anand, Inder, additional, Ouwerkerk, Wouter, additional, Chandramouli, Chanchal, additional, Huang, Weiting, additional, Lawson, Claire A., additional, Kadam, Umesh T., additional, Yap, Jonathan, additional, Lim, Shirlynn, additional, Hung, Chung-Lieh, additional, MacDonald, Michael Ross, additional, Loh, Seet Yoong, additional, Shimizu, Wataru, additional, Tromp, Jasper, additional, Lam, Carolyn Su Ping, additional, Ling, Lieng Hsi, additional, Liew, Houng Bang, additional, Narasimhan, Calambur, additional, Ngarmukos, Tachapong, additional, Park, Sang Weon, additional, Reyes, Eugenio, additional, Siswanto, Bambang B., additional, Zhang, Shu, additional, Fan, Xiaohan, additional, Chen, Keping, additional, Wu, Liqun, additional, Xie, Yucai, additional, Jin, Qi, additional, Ling, Tianyou, additional, Li, Xinli, additional, Zhou, Fang, additional, Zhou, Yanli, additional, Xu, Dongjie, additional, Zhang, Haifeng, additional, Su, Yangang, additional, Chen, Xueying, additional, Qin, Shengmei, additional, Wang, Jingfeng, additional, Gong, Xue, additional, Wu, Zhaodi, additional, Yu, Cheuk Man, additional, Sastry, B K S, additional, Gopi, Arun, additional, Raghu, K, additional, Sridevi, C, additional, Kaur, Daljeet, additional, Naik, Ajay, additional, Parikh, Keyur, additional, Chandarana, Anish, additional, Shah, Urmil, additional, Chag, Milan, additional, Baxi, Hemang, additional, Gupta, Satya, additional, Bhatia, Jyoti, additional, Khakhkhar, Vaishali, additional, Sankhla, Vineet, additional, Patel, Tejas, additional, Kapoor, Vipul, additional, Wander, Gurpreet Singh, additional, Tandon, Rohit, additional, Chopra, Vijay, additional, Kumar, Manoj, additional, Singh Sethi, Hatinder Jeet, additional, Verma, Rashmi, additional, Mittal, Sanjay, additional, Sawhney, Jitendra, additional, Sharma, Manish Kr., additional, Purayil, Mohanan Padinhare, additional, Siswanto, Bambang Budi, additional, Sadikin, RS Dr Hasan, additional, Tedjokusumo, Pintoko, additional, Martanto, Erwan, additional, Munawar, Muhammad, additional, Pambudi, Jimmy Agung, additional, Karawaci, RS Siloam, additional, Lukito, Antonia, additional, Pardede, Ingrid, additional, Thengker, Alvin, additional, Damay, Vito, additional, Danny, Siska Suridanda, additional, Surarso, Rarsari, additional, Noda, Takashi, additional, Nakajima, Ikutaro, additional, Wada, Mitsuru, additional, Ishibashi, Kohei, additional, Kurita, Takashi, additional, Yasuoka, Ryoubun, additional, Asai, Kuniya, additional, Murai, Kohji, additional, Kubota, Yoshiaki, additional, Izumi, Yuki, additional, Ikeda, Takanori, additional, Hisatake, Shinji, additional, Kabuki, Takayuki, additional, Kiuchi, Shunsuke, additional, Hagiwara, Nobuhisa, additional, Suzuki, Atsushi, additional, Suzuki, Dr Tsuyoshi, additional, Park, Sang-Weon, additional, Hong, Suk Keun, additional, Lee, SookJin, additional, Soo, Lim Dal, additional, Kim, Dong-Hyeok, additional, Shim, Jaemin, additional, Park, Seong-Mi, additional, Roh, Seung-Young, additional, Kim, Young Hoon, additional, Kim, Mina, additional, Choi, Jong-Il, additional, Na, Jin Oh, additional, Rha, Seung Woon, additional, Seo, Hong Seog, additional, Oh, Dong Joo, additional, Park, Chang Gyu, additional, Kim, Eung Ju, additional, Lee, Sunki, additional, Joung, Boyoung, additional, Uhm, Jae-Sun, additional, Lee, Moon Hyoung, additional, Cho, In-Jeong, additional, Park, Hui-Nam, additional, Park, Hyung-Wook, additional, Cho, Jeong-Gwan, additional, Yoon, Namsik, additional, Lee, KiHong, additional, Kim, Kye Hun, additional, Kim, Seong Hwan, additional, Saharudin, Sahrin, additional, Beh, Boon Cong, additional, Lee, Yu Wei, additional, Yen, Chia How, additional, Othman, Mohd Khairi, additional, Augustine, Amie-Anne, additional, Mohd Asnawi, Mohd Hariz, additional, Mojolou, Roberto Angelo, additional, Tan, You Zhuan, additional, Arbain, Aida Nurbaini, additional, Wong, Chii Koh, additional, Omar, Razali, additional, Ghazi, Azmee Mohd, additional, Khelae, Surinder Kaur, additional, Chew, David S.P., additional, Yap, Lok Bin, additional, Hussin, Azlan, additional, Muhammad, Zulkeflee, additional, Azmee, Mohd. Ghazi, additional, Abidin, Imran Zainal, additional, Mahmood Zhudi, Ahmad Syadi Bin, additional, Md Sari, Nor Ashikin, additional, Sridhar, Ganiga Srinivasaiah, additional, Mahmood Zuhdi, Ahmad Syadi, additional, Ismail, Muhammad Dzafir, additional, Ong, Tiong Kiam, additional, Cham, Yee Ling, additional, Khiew, Ning Zan, additional, Said, Asri Bin, additional, Yip Fong, Alan Yean, additional, Mohd Amin, Nor Hanim, additional, Seng, Keong Chua, additional, Tan, Sian Kong, additional, Yew, Kuan Leong, additional, Santos, Jones, additional, Lim, Allan, additional, Lapitan, Raul, additional, Andal, Ryan, additional, Lopez, Eleanor, additional, David Sim, Kheng Leng, additional, Tan, Boon Yew, additional, Lim, Choon Pin, additional, Teo, Louis L.Y., additional, Chan, Laura L.H., additional, Chai, Ping, additional, Raymond Wong, Ching Chiew, additional, Poh, Kian Keong, additional, Daniel Yeo, Poh Shuan, additional, Lee, Evelyn M., additional, Ching, Min Er, additional, Khoo, Deanna Z.L., additional, Yew, Min Sen, additional, Huang, Wenjie, additional, Gerard Leong, Kui Toh, additional, Jason See, Jia Hao, additional, Lim, Yaozong Benji, additional, Tan, Svenszeat, additional, Yeo, Colin, additional, Chai, Siang Chew, additional, Jaufeerally, Fazlur Rehman, additional, Tulsidas, Haresh, additional, Aung, Than, additional, Ong, Hean Yee, additional, Ling, Lee Fong, additional, Soon, Dinna Kar Nee, additional, Yeh, Hung-I, additional, Kuo, Jen-Yuan, additional, Yen, Chih-Hsuan, additional, Hwang, Juey-Jen, additional, Chien, Kuo-Liong, additional, Su, Ta-Chen, additional, Lin, Lian-Yu, additional, Juang, Jyh-Ming, additional, Lin, Yen-Hung, additional, Chiang, Fu-Tien, additional, Lin, Jiunn-Lee, additional, Ho, Yi-Lwun, additional, Lee, Chii-Ming, additional, Lin, Po-Chih, additional, Hung, Chi-Sheng, additional, Chang, Sheng-Nan, additional, Lin, Jou-Wei, additional, Hsu, Chih-Neng, additional, Yu, Wen-Chung, additional, Chao, Tze-Fan, additional, Sung, Shih-Hsien, additional, Wang, Kang-Ling, additional, Leu, Hsin-Bang, additional, Lin, Yenn-Jiang, additional, Chang, Shih-Lin, additional, Huang, Po-Hsun, additional, Lo, Li-Wei, additional, Wu, Cheng-Hsueh, additional, Liang, Hsin-Yueh, additional, Chang, Shih-Sheng, additional, Hsiao, Lien-Cheng, additional, Wang, Yu-Chen, additional, Lu, Chiung-Ray, additional, Wu, Hung-Pin, additional, Lin, Yen-Nien, additional, Chen, Ke-Wei, additional, Lo, Ping-Han, additional, Hsu, Chung-Ho, additional, Hsieh, Li-Chuan, additional, Chandavimol, Mann, additional, Yingchoncharoen, Teerapat, additional, Laothavorn, Prasart, additional, Tiyanon, Waraporn, additional, Wongcharoen, Wanwarang, additional, and Phrommintikul, Arintaya, additional

Published
2021
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13. Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore

Author

Wu, Degang, primary, Dou, Jinzhuang, additional, Chai, Xiaoran, additional, Bellis, Claire, additional, Wilm, Andreas, additional, Shih, Chih Chuan, additional, Soon, Wendy Wei Jia, additional, Bertin, Nicolas, additional, Lin, Clarabelle Bitong, additional, Khor, Chiea Chuen, additional, DeGiorgio, Michael, additional, Cheng, Shanshan, additional, Bao, Li, additional, Karnani, Neerja, additional, Hwang, William Ying Khee, additional, Davila, Sonia, additional, Tan, Patrick, additional, Shabbir, Asim, additional, Moh, Angela, additional, Tan, Eng-King, additional, Foo, Jia Nee, additional, Goh, Liuh Ling, additional, Leong, Khai Pang, additional, Foo, Roger S.Y., additional, Lam, Carolyn Su Ping, additional, Richards, Arthur Mark, additional, Cheng, Ching-Yu, additional, Aung, Tin, additional, Wong, Tien Yin, additional, Ng, Huck Hui, additional, Liu, Jianjun, additional, Wang, Chaolong, additional, Ackers-Johnson, Matthew Andrew, additional, Aliwarga, Edita, additional, Ban, Kenneth Hon Kim, additional, Bertrand, Denis, additional, Chambers, John C., additional, Chan, Dana Leng Hui, additional, Chan, Cheryl Xue Li, additional, Chee, Miao Li, additional, Chee, Miao Ling, additional, Chen, Pauline, additional, Chen, Yunxin, additional, Chew, Elaine Guo Yan, additional, Chew, Wen Jie, additional, Chiam, Lynn Hui Yun, additional, Chong, Jenny Pek Ching, additional, Chua, Ivan, additional, Cook, Stuart A., additional, Dai, Wei, additional, Dorajoo, Rajkumar, additional, Foo, Chuan-Sheng, additional, Goh, Rick Siow Mong, additional, Hillmer, Axel M., additional, Irwan, Ishak D., additional, Jaufeerally, Fazlur, additional, Javed, Asif, additional, Jeyakani, Justin, additional, Koh, John Tat Hung, additional, Koh, Jia Yu, additional, Krishnaswamy, Pavitra, additional, Kuan, Jyn Ling, additional, Kumari, Neelam, additional, Lee, Ai Shan, additional, Lee, Seow Eng, additional, Lee, Sheldon, additional, Lee, Yen Ling, additional, Leong, See Ting, additional, Li, Zheng, additional, Li, Peter Yiqing, additional, Liew, Jun Xian, additional, Liew, Oi Wah, additional, Lim, Su Chi, additional, Lim, Weng Khong, additional, Lim, Chia Wei, additional, Lim, Tingsen Benson, additional, Lim, Choon Kiat, additional, Loh, Seet Yoong, additional, Lok, Au Wing, additional, Chin, Calvin W.L., additional, Majithia, Shivani, additional, Maurer-Stroh, Sebastian, additional, Meah, Wee Yang, additional, Mok, Shi Qi, additional, Nargarajan, Niranjan, additional, Ng, Pauline, additional, Ng, Sarah B., additional, Ng, Zhenyuan, additional, Ng, Jessica Yan Xia, additional, Ng, Ebonne, additional, Ng, Shi Ling, additional, Nusinovici, Simon, additional, Ong, Chin Thing, additional, Pan, Bangfen, additional, Pedergnana, Vincent, additional, Poh, Stanley, additional, Prabhakar, Shyam, additional, Prakash, Kumar M., additional, Quek, Ivy, additional, Sabanayagam, Charumathi, additional, See, Wei Qiang, additional, Sia, Yee Yen, additional, Sim, Xueling, additional, Sim, Wey Cheng, additional, So, Jimmy, additional, Soon, Dinna K.N., additional, Tai, E. Shyong, additional, Tan, Nicholas Y., additional, Tan, Louis C.S., additional, Tan, Hong Chang, additional, Tan, Wilson Lek Wen, additional, Tandiono, Moses, additional, Tay, Amanda, additional, Thakur, Sahil, additional, Tham, Yih Chung, additional, Tiang, Zenia, additional, Toh, Grace Li-Xian, additional, Tsai, Pi Kuang, additional, Veeravalli, Lavanya, additional, Verma, Chandra S., additional, Wang, Ling, additional, Wang, Min Rui, additional, Wong, Wing-Cheong, additional, Xie, Zhicheng, additional, Yeo, Khung Keong, additional, Zhang, Liang, additional, Zhai, Weiwei, additional, and Zhao, Yi, additional

Published
2019
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14. Cognitive impairment in Asian patients with heart failure: prevalence, biomarkers, clinical correlates, and outcomes

Author

Dong, YanHong, primary, Teo, Shuan Yong, additional, Kang, Kathleen, additional, Tan, Melissa, additional, Ling, Lieng Hsi, additional, Yeo, Poh Shuan Daniel, additional, Sim, David, additional, Jaufeerally, Fazlur, additional, Leong, Kui Toh Gerard, additional, Ong, Hean Yee, additional, Soon, Dinna, additional, Lee, Sheldon, additional, Loh, Seet Yoong, additional, Tan, Ru San, additional, Chan, Siew Pang, additional, Richards, Arthur Mark, additional, and Lam, Carolyn Su Ping, additional

Published
2019
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15. Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore

Author

Wu, Degang, Dou, Jinzhuang, Chai, Xiaoran, Bellis, Claire, Wilm, Andreas, Shih, Chih Chuan, Soon, Wendy Wei Jia, Bertin, Nicolas, Lin, Clarabelle Bitong, Khor, Chiea Chuen, DeGiorgio, Michael, Cheng, Shanshan, Bao, Li, Karnani, Neerja, Hwang, William Ying Khee, Davila, Sonia, Tan, Patrick, Shabbir, Asim, Moh, Angela, Tan, Eng King, Foo, Jia Nee, Goh, Liuh Ling, Leong, Khai Pang, Foo, Roger S.Y., Lam, Carolyn Su Ping, Richards, Arthur Mark, Cheng, Ching Yu, Aung, Tin, Wong, Tien Yin, Ng, Huck Hui, Ackers-Johnson, Matthew Andrew, Aliwarga, Edita, Ban, Kenneth Hon Kim, Bertrand, Denis, Chambers, John C., Chan, Dana Leng Hui, Chan, Cheryl Xue Li, Chee, Miao Li, Chee, Miao Ling, Chen, Pauline, Chen, Yunxin, Chew, Elaine Guo Yan, Chew, Wen Jie, Chiam, Lynn Hui Yun, Chong, Jenny Pek Ching, Chua, Ivan, Cook, Stuart A., Dai, Wei, Dorajoo, Rajkumar, Foo, Chuan Sheng, Goh, Rick Siow Mong, Hillmer, Axel M., Irwan, Ishak D., Jaufeerally, Fazlur, Javed, Asif, Jeyakani, Justin, Koh, John Tat Hung, Koh, Jia Yu, Krishnaswamy, Pavitra, Kuan, Jyn Ling, Kumari, Neelam, Lee, Ai Shan, Lee, Seow Eng, Lee, Sheldon, Lee, Yen Ling, Leong, See Ting, Li, Zheng, Li, Peter Yiqing, Liew, Jun Xian, Liew, Oi Wah, Lim, Su Chi, Lim, Weng Khong, Lim, Chia Wei, Lim, Tingsen Benson, Lim, Choon Kiat, Loh, Seet Yoong, Lok, Au Wing, Chin, Calvin W.L., Majithia, Shivani, Maurer-Stroh, Sebastian, Meah, Wee Yang, Mok, Shi Qi, Nargarajan, Niranjan, Ng, Pauline, Ng, Sarah B., Ng, Zhenyuan, Ng, Jessica Yan Xia, Ng, Ebonne, Ng, Shi Ling, Nusinovici, Simon, Ong, Chin Thing, Pan, Bangfen, Pedergnana, Vincent, Poh, Stanley, Prabhakar, Shyam, Prakash, Kumar M., Quek, Ivy, Sabanayagam, Charumathi, See, Wei Qiang, Sia, Yee Yen, Sim, Xueling, Sim, Wey Cheng, So, Jimmy, Soon, Dinna K.N., Tai, E. Shyong, Tan, Nicholas Y., Tan, Louis C.S., Tan, Hong Chang, Tan, Wilson Lek Wen, Tandiono, Moses, Tay, Amanda, Thakur, Sahil, Tham, Yih Chung, Tiang, Zenia, Toh, Grace Li Xian, Tsai, Pi Kuang, Veeravalli, Lavanya, Verma, Chandra S., Wang, Ling, Wang, Min Rui, Wong, Wing Cheong, Xie, Zhicheng, Yeo, Khung Keong, Zhang, Liang, Zhai, Weiwei, Zhao, Yi, Liu, Jianjun, Wang, Chaolong, other, and, Wu, Degang, Dou, Jinzhuang, Chai, Xiaoran, Bellis, Claire, Wilm, Andreas, Shih, Chih Chuan, Soon, Wendy Wei Jia, Bertin, Nicolas, Lin, Clarabelle Bitong, Khor, Chiea Chuen, DeGiorgio, Michael, Cheng, Shanshan, Bao, Li, Karnani, Neerja, Hwang, William Ying Khee, Davila, Sonia, Tan, Patrick, Shabbir, Asim, Moh, Angela, Tan, Eng King, Foo, Jia Nee, Goh, Liuh Ling, Leong, Khai Pang, Foo, Roger S.Y., Lam, Carolyn Su Ping, Richards, Arthur Mark, Cheng, Ching Yu, Aung, Tin, Wong, Tien Yin, Ng, Huck Hui, Ackers-Johnson, Matthew Andrew, Aliwarga, Edita, Ban, Kenneth Hon Kim, Bertrand, Denis, Chambers, John C., Chan, Dana Leng Hui, Chan, Cheryl Xue Li, Chee, Miao Li, Chee, Miao Ling, Chen, Pauline, Chen, Yunxin, Chew, Elaine Guo Yan, Chew, Wen Jie, Chiam, Lynn Hui Yun, Chong, Jenny Pek Ching, Chua, Ivan, Cook, Stuart A., Dai, Wei, Dorajoo, Rajkumar, Foo, Chuan Sheng, Goh, Rick Siow Mong, Hillmer, Axel M., Irwan, Ishak D., Jaufeerally, Fazlur, Javed, Asif, Jeyakani, Justin, Koh, John Tat Hung, Koh, Jia Yu, Krishnaswamy, Pavitra, Kuan, Jyn Ling, Kumari, Neelam, Lee, Ai Shan, Lee, Seow Eng, Lee, Sheldon, Lee, Yen Ling, Leong, See Ting, Li, Zheng, Li, Peter Yiqing, Liew, Jun Xian, Liew, Oi Wah, Lim, Su Chi, Lim, Weng Khong, Lim, Chia Wei, Lim, Tingsen Benson, Lim, Choon Kiat, Loh, Seet Yoong, Lok, Au Wing, Chin, Calvin W.L., Majithia, Shivani, Maurer-Stroh, Sebastian, Meah, Wee Yang, Mok, Shi Qi, Nargarajan, Niranjan, Ng, Pauline, Ng, Sarah B., Ng, Zhenyuan, Ng, Jessica Yan Xia, Ng, Ebonne, Ng, Shi Ling, Nusinovici, Simon, Ong, Chin Thing, Pan, Bangfen, Pedergnana, Vincent, Poh, Stanley, Prabhakar, Shyam, Prakash, Kumar M., Quek, Ivy, Sabanayagam, Charumathi, See, Wei Qiang, Sia, Yee Yen, Sim, Xueling, Sim, Wey Cheng, So, Jimmy, Soon, Dinna K.N., Tai, E. Shyong, Tan, Nicholas Y., Tan, Louis C.S., Tan, Hong Chang, Tan, Wilson Lek Wen, Tandiono, Moses, Tay, Amanda, Thakur, Sahil, Tham, Yih Chung, Tiang, Zenia, Toh, Grace Li Xian, Tsai, Pi Kuang, Veeravalli, Lavanya, Verma, Chandra S., Wang, Ling, Wang, Min Rui, Wong, Wing Cheong, Xie, Zhicheng, Yeo, Khung Keong, Zhang, Liang, Zhai, Weiwei, Zhao, Yi, Liu, Jianjun, Wang, Chaolong, and other, and

Abstract

Because of Singapore's unique history of immigration, whole-genome sequence analysis of 4,810 Singaporeans provides a snapshot of the genetic diversity across East, Southeast, and South Asia.

Published
2019

16. Novel insights into heart failure with preserved ejection fraction

Author

Lam, Carolyn Su Ping, Lam, Carolyn Su Ping, Lam, Carolyn Su Ping, and Lam, Carolyn Su Ping

Abstract

Tot 2 decennia geleden stond hartfalen synoniem voor “pompfalen”, waarbij de pompfunctie niet in staat was om voldoende eigen volume bloed (ejectiefractie) uit te pompen. Inmiddels is het bekend dat er ook hartfalen kan bestaan bij een situatie waarbij de ejectiefractie normaal is. Dit syndroom, dat in ongeveer 50% van alle patiënten met hartfalen bestaat, wordt ook wel “hartfalen met behouden ejectiefractie genoemd. Dit syndroom treft vooral oudere vrouwen en neemt in sterke mate toe, vanwege het ouder worden van de populatie. Hartfalen met behouden ejectiefractie is een dodelijke aandoening, waarbij patiënten ernstige klachten ervaren, maar tot op heden zijn er nog steeds geen effectieve behandelingsopties gevonden. Dit komt vooral omdat er nog onvoldoende kennis is over de achtergrond een de oorzaak van de aandoening. Daarom is hartfalen met behouden ejectiefractie een van de belangrijkste uitdagingen voor het onderzoek naar hart- en vaatziekten. Dit proefschrift beschrijft deze uitdaging en geeft meer inzicht in ziektemechanismen van hartfalen met behouden ejectiefractie. Er wordt gesuggereerd dat dit niet alleen een ziekte is van het hart, maar tevens van de bloedvaten en van andere organen in het lichaam. Het is opvallend dat veel van deze ziektemechanismen meer uitgesproken zijn bij vrouwen dan bij mannen. Het bewijs begint zich op te stapelen dat de binnenbekleding van alle bloedvaten (het endotheel) en stikstofoxide, een belangrijke rol spelen bij dit ziektebeeld. Deze kennis zal bijdragen aan het ontwikkelen van specifieke geneesmiddelen, waarvan op dit moment de werking bij patiënten met hartfalen en behouden ejectiefractie wordt onderzocht. Dit proefschrift geeft tevens een overzicht van de toekomstperspectieven en het vinden van betere behandelingsmethoden voor deze belangrijke aandoening.

Published
2016

17. Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction

Author

Pharmaceutics, Afd Pharmaceutics, Allijn, Iris E., Czarny, Bertrand M S, Wang, Xiaoyuan, Chong, Suet Yen, Weiler, Marek, da Silva, Acarilia Eduardo, Metselaar, Josbert M., Lam, Carolyn Su Ping, Pastorin, Giorgia, de Kleijn, Dominique P V, Storm, G, Wang, Jiong Wei, Schiffelers, Raymond M., Pharmaceutics, Afd Pharmaceutics, Allijn, Iris E., Czarny, Bertrand M S, Wang, Xiaoyuan, Chong, Suet Yen, Weiler, Marek, da Silva, Acarilia Eduardo, Metselaar, Josbert M., Lam, Carolyn Su Ping, Pastorin, Giorgia, de Kleijn, Dominique P V, Storm, G, Wang, Jiong Wei, and Schiffelers, Raymond M.

Published
2017

18. Liposome encapsulated berberine treatment attenuates cardiac dysfunction after myocardial infarction

Author

Infection & Immunity, Circulatory Health, Zorgeenheid Vaatchirurgie Medisch, CDL Staf Research, Allijn, Iris E., Czarny, Bertrand M S, Wang, Xiaoyuan, Chong, Suet Yen, Weiler, Marek, da Silva, Acarilia Eduardo, Metselaar, Josbert M., Lam, Carolyn Su Ping, Pastorin, Giorgia, de Kleijn, Dominique P V, Storm, Gert, Wang, Jiong Wei, Schiffelers, Raymond M., Infection & Immunity, Circulatory Health, Zorgeenheid Vaatchirurgie Medisch, CDL Staf Research, Allijn, Iris E., Czarny, Bertrand M S, Wang, Xiaoyuan, Chong, Suet Yen, Weiler, Marek, da Silva, Acarilia Eduardo, Metselaar, Josbert M., Lam, Carolyn Su Ping, Pastorin, Giorgia, de Kleijn, Dominique P V, Storm, Gert, Wang, Jiong Wei, and Schiffelers, Raymond M.

Published
2017

24. Impact of the joint association between sex, age and diabetes on long-term mortality after acute myocardial infarction

Author

Gao, Fei, primary, Lam, Carolyn Su Ping, additional, Sim, Ling Ling, additional, Koh, Tian Hai, additional, Foo, David, additional, Ong, Hean Yee, additional, Tong, Khim Leng, additional, Tan, Huay Cheem, additional, Machin, David, additional, Wong, Kok Seng, additional, Chan, Mark Yan Yee, additional, and Chua, Terrance Siang Jin, additional

Published
2015
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25. Vascular Health Indices and Cognitive Domain Function: Singapore Longitudinal Ageing Studies.

Author

Shir Lynn Lim, Qi Gao, Ma Shwe Zin Nyunt, Lingli Gong, Lunaria, Josephine B., May Li Lim, Ling, Audrey, Carolyn Su-Ping Lam, Richards, Arthur Mark, Lieng Hsi Ling, Tze Pin Ng, Lim, Shir Lynn, Gao, Qi, Nyunt, Ma Shwe Zin, Gong, Lingli, Lim, May Li, Lam, Carolyn Su-Ping, Ling, Lieng Hsi, and Ng, Tze Pin

Subjects
MILD cognitive impairment, NEUROPSYCHOLOGICAL tests, UNILATERAL neglect, HEART diseases, COGNITION disorders, DIAGNOSIS, BLOOD flow measurement, BLOOD pressure, CARDIOVASCULAR diseases, CARDIOVASCULAR system physiology, HEMODYNAMICS, LONGITUDINAL method, QUESTIONNAIRES, CAROTID intima-media thickness
Abstract

Background: Few studies have comprehensively evaluated the relationship between vascular disease and cognition of older adults without cardiac disease.Objective: We explored the associations of structural atherosclerosis, vascular stiffness, and reactivity with global, memory, attention, language, visuospatial ability, and executive function in community-dwelling, non-demented older Asians without cardiac diseases.Methods: Cognition was assessed by Mini-Mental State Examination (MMSE) (n = 308) and detailed neuropsychological tests (n = 155). Vascular measures included carotid intima-media thickness; aortic stiffness [carotid-femoral pulse wave velocity (CFPWV), aortic augmentation index (AI), and aortic pulse pressure (PP)]; carotid stiffness [elasticity modulus (Ep), beta index (β), arterial compliance (AC), carotid AI]; and endothelial function [reactive hyperemia index (RHI)]. Multivariable analyses controlled for potential confounding by demographics, apolipoprotein E genotype and cardiovascular risk factors.Results: The participants' mean age was 63.0 ± 6.1 years. Inverse associations with MMSE were found for AC (β= 0.128, p = 0.019), Ep (β= -0.151, p = 0.008), β index (β= -0.122, p = 0.029), carotid stiffness z-score (β= -0.154, p = 0.007); with executive function for CFPWV (β= -0.209, p = 0.026), AC (β= 0.214, p = 0.005), Ep (β= -0.160, p = 0.050), β index (β= -0.165, p = 0.041), and both aortic (β= -0.229, p = 0.010) and carotid (β= -0.208, p = 0.010) stiffness z-scores; with verbal memory for AI (β= -0.229, p = 0.004) and aortic (β= -0.263, p = 0.004) stiffness z-score; with language for AI (β= -0.155, p = 0.025), aortic stiffness z-score (β= -0.196, p = 0.011). RHI positively correlated with visuospatial ability (β= 0.195, p = 0.013) and executive function (β= 0.151, p = 0.045).Conclusion: The results support a link between systemic vascular health and neurocognitive function in older Asian adults. Subclinical noninvasive measures of arterial stiffness and reactivity may identify individuals vulnerable to cognitive impairment. [ABSTRACT FROM AUTHOR]

Published
2016
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26. Breakthrough in heart failure with preserved ejection fraction: are we there yet?

Author

Lim SL and Lam CS

Subjects
Animals, Heart Failure diagnosis, Heart Failure metabolism, Heart Failure therapy, Humans, Inflammation diagnosis, Inflammation metabolism, Inflammation therapy, Inflammation Mediators metabolism, Prognosis, Risk Factors, Signal Transduction, Endothelium, Vascular physiopathology, Heart Failure physiopathology, Inflammation physiopathology, Stroke Volume, Ventricular Function, Left
Abstract

Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective therapies underscores our incomplete understanding of this complex heterogeneous syndrome. A novel paradigm has recently emerged, in which central roles are ascribed to systemic inflammation and generalized endothelial dysfunction in the pathophysiology of HFPEF. In this review, we discuss the role of the endothelium in cardiovascular homeostasis and how deranged endothelial-related signaling pathways contribute to the development of HFPEF. We also review the novel therapies in various stages of research and development that target different components of this signaling pathway.

Published
2016
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