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15 results on '"Lalumera M"'

3. The 'switch-off' mechanism of spontaneous resolution of acute gout attack

Author

Marcolongo R, Aa, Calabria, Lalumera M, Gerli R, Alessandrini C, and Cavallo G

Subjects
Inflammation, Gout, Neutrophils, Remission, Spontaneous, Calorimetry, Uric Acid, Kinetics, Durapatite, Superoxides, Acute Disease, Luminescent Measurements, Microscopy, Electron, Scanning, Urea, Humans, Hydroxyapatites, Lymphocytes, Allantoin, Acute-Phase Reaction, Crystallization
Abstract

Urate crystal size change and the modification of coated proteins by oxygen radicals released by stimulated polymorphonuclear cells (PMN) could represent a likely "switch-off" mechanism of the spontaneous resolution of acute gout attack. The absorption spectra and the uric acid, allantoin and urea concentrations were determined before and after in vitro exposition of monosodium urate (MSU) crystals to superoxide anion (O2) photochemically generated. The results showed a complete dissolution of MSU crystals after incubation under O2-, with decrease of uric acid and increase of allantoin and urea concentrations. Our results were confirmed by polarizing, electron microscopy and calorimetric techniques. The results obtained seem to confirm that the spontaneous resolution of acute gout attack could be attributed to the dissolving effect on urate crystals and the modification of coated proteins by O2- released by phagocytizing PMN.

Published
1988

4. [Possible mechanism of action of drugs in the basic therapy of rheumatoid arthritis: effect on platelet aggregation]

Author

Fioravanti A, Lolatte V, Nicola Giordano, Frati E, Ml, Castagna, Morozzi G, Lalumera M, and Marcolongo R

Subjects
Adenosine Diphosphate, Adult, Arthritis, Rheumatoid, Aurothioglucose, Time Factors, Platelet Aggregation, Auranofin, Penicillamine, Humans, Gold, Gold Sodium Thiomalate
Abstract

As it is known that platelets play an important role in arising and maintaining the inflammation, the authors have studied "in vitro", the effect on platelet aggregation of three drugs (Sodium Aurothiomalate, Auranofin and Penicillamine) used in basic therapy of Rheumatoid Arthritis (RA). The drugs are used in different concentrations and at different times of preincubation. The study was based on the principle of Born and using the Coagg-Salus aggregometer. The platelet aggregation was induced by ADP 2.5 microM. The authors have demonstrated that the above-named drugs inhibit the platelet aggregation induced by ADP in different percentile, according to the concentrations adopted and the time of preincubation with platelets rich plasma. This study seems particularly interesting because it can offer a possible interpretation on the mechanism of action of basic therapy in RA.

6. The "switch-off" mechanism of spontaneous resolution of acute gout attack.

Author

Marcolongo R, Calabria AA, Mazzullo G, Lalumera M, Morozzi G, and Cavallo G

Subjects
Acute Disease, Allantoin blood, Crystallization, Durapatite, Humans, Hydroxyapatites, Kinetics, Luminescent Measurements, Microscopy, Electron, Scanning, Neutrophils physiology, Neutrophils ultrastructure, Superoxides blood, Urea blood, Uric Acid blood, Gout physiopathology
Published
1986
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7. [In vitro effects of non-steroidal anti-inflammatory drugs on production of oxygen radicals evaluated by the chemiluminescent response of polymorphonuclear leukocytes].

Author

Mazzullo G, Calabria AA, Lalumera M, Fioravanti A, Bacarelli MR, Pucci G, and Renieri A

Subjects
Arthritis, Rheumatoid pathology, Aspirin pharmacology, Cell Membrane drug effects, Diclofenac pharmacology, Free Radicals, Humans, Indomethacin pharmacology, Luminescent Measurements, Neutrophils drug effects, Piroxicam, Thiazines pharmacology, Zymosan pharmacology, Anti-Inflammatory Agents pharmacology, Neutrophils metabolism, Oxygen metabolism
Published
1985

8. [The production of superoxide anion (O2-) by polymorphonuclear cells in patients with rheumatoid arthritis].

Author

Lalumera M, Berti C, Pellegrini R, Morozzi G, and Marcolongo R

Subjects
Adult, Aged, Herpesvirus 4, Human metabolism, Humans, Middle Aged, Mycoplasma metabolism, Rheumatoid Factor pharmacology, Synovial Fluid metabolism, Synovial Membrane metabolism, Zymosan pharmacology, Arthritis, Rheumatoid blood, Neutrophils metabolism, Oxygen blood, Superoxides blood
Abstract

Superoxide anion production has been determined in controls and RA patients PMNs stimulated with zymosan, rheumatoid synovial membrane, nodule and synovial fluid, rheumatoid factor, aggregated gamma-globulins, Mycoplasma and Epstein-Barr virus. Patients with RA showed an increased production of O2- after incubation with zymosan and rheumatoid tissue extracts or synovial fluid in comparison to normal controls. The findings indicate that rheumatoid PMNs become activated by different stimuli to produce an excess of O2- which can contribute to chronic inflammatory process.

Published
1982

9. [Possible mechanism of action of drugs in the basic therapy of rheumatoid arthritis: effect on platelet aggregation].

Author

Fioravanti A, Lolatte V, Giordano N, Frati E, Castagna ML, Morozzi G, Lalumera M, and Marcolongo R

Subjects
Adenosine Diphosphate pharmacology, Adult, Arthritis, Rheumatoid blood, Auranofin, Aurothioglucose therapeutic use, Humans, Time Factors, Arthritis, Rheumatoid drug therapy, Aurothioglucose analogs & derivatives, Gold analogs & derivatives, Gold Sodium Thiomalate therapeutic use, Penicillamine therapeutic use, Platelet Aggregation drug effects
Abstract

As it is known that platelets play an important role in arising and maintaining the inflammation, the authors have studied "in vitro", the effect on platelet aggregation of three drugs (Sodium Aurothiomalate, Auranofin and Penicillamine) used in basic therapy of Rheumatoid Arthritis (RA). The drugs are used in different concentrations and at different times of preincubation. The study was based on the principle of Born and using the Coagg-Salus aggregometer. The platelet aggregation was induced by ADP 2.5 microM. The authors have demonstrated that the above-named drugs inhibit the platelet aggregation induced by ADP in different percentile, according to the concentrations adopted and the time of preincubation with platelets rich plasma. This study seems particularly interesting because it can offer a possible interpretation on the mechanism of action of basic therapy in RA.

Published
1984

11. [In vitro study on the possible inflammatory mechanism of ferrous ions: effect on the production of oxygen free radicals].

Author

Calabria AA, Lalumera M, Mazzullo G, Giordano N, Cavallo G, Morozzi G, and Marcolongo R

Subjects
Arthritis, Rheumatoid pathology, Deferoxamine pharmacology, Humans, Hydroxides, Hydroxyl Radical, In Vitro Techniques, Luminescent Measurements, Zymosan pharmacology, Ferric Compounds pharmacology, Ferrous Compounds pharmacology, Iron pharmacology, Neutrophils drug effects, Oxygen metabolism
Published
1985

12. [Effect of inflammation mediators and antirheumatic drugs on the production of superoxide anion (O2-) by polymorphonuclear cells in normals and rheumatoid arthritis].

Author

Pellegrini R, Lalumera M, Berti C, Morozzi G, and Marcolongo R

Subjects
Adrenal Cortex Hormones pharmacology, Alprostadil, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Cyclic AMP pharmacology, Cyclic GMP pharmacology, Humans, Neutrophils drug effects, Prostaglandins E pharmacology, Theophylline pharmacology, Arthritis, Rheumatoid blood, Neutrophils metabolism, Oxygen blood, Superoxides blood
Published
1982

13. [Inhibition of fructose-induced hyperuricacidemia by pretreatment with phosphates].

Author

Morozzi G, Berti C, Pellegrini R, Lalumera M, and Marcolongo R

Subjects
Acidosis chemically induced, Adenine Nucleotides metabolism, Adenosine Triphosphate metabolism, Humans, Liver metabolism, Acidosis prevention & control, Fructose, Phosphates therapeutic use, Uric Acid blood
Abstract

To test the hypothesis that intravenous injections of fructose rapidly decreases liver ATP and Pi and results in the rapid degradation of adenine nucleotides and hyperuricemia, fructose was administered intravenously to a group of normal and gouty subjects; 4 gouty patients were treated with a phosphate solution prior fructose loading. The results obtained show that fructose administration plus phosphate solution prevents Pi depletion and inhibits fructose-induced hyperuricemia.

Published
1982

14. In vitro and ex vivo effects of different corticosteroids on polymorphonuclear leukocyte functions.

Author

Marcolongo R, Lalumera M, Calabria A, and Imbimbo B

Subjects
Adult, Arthritis, Rheumatoid blood, Arthritis, Rheumatoid physiopathology, Cells, Cultured, Chemotaxis, Leukocyte drug effects, Dose-Response Relationship, Drug, Female, Humans, Kinetics, Luminescent Measurements, Middle Aged, Neutrophils physiology, Superoxides metabolism, Zymosan pharmacology, Betamethasone pharmacology, Methylprednisolone pharmacology, Neutrophils drug effects, Pregnenediones pharmacology
Published
1984

15. [Drug-induced changes in chemotaxis under normal conditions and in rheumatoid arthritis].

Author

Berti C, Pellegrini R, Lalumera M, Morozzi G, and Marcolongo R

Subjects
Alprostadil, Anti-Inflammatory Agents, Non-Steroidal pharmacology, Arthritis, Rheumatoid drug therapy, Cyclic AMP pharmacology, Cyclic GMP pharmacology, Humans, Immunosuppressive Agents pharmacology, Neutrophils, Prostaglandins E pharmacology, Arthritis, Rheumatoid blood, Chemotaxis, Leukocyte drug effects
Abstract

The effects of agents used in RA treatment, various drugs, RF, rheumatoid nodule and synovial fluid was studied on chemotaxis of PMNs. NSAIDS, corticosteroids, theophylline, colchicine, SOD, RF, rheumatoid nodule and synovial fluid were found to inhibit the chemotactic responsiveness while AMPc, GMPc, PGEI and immunodulator drugs enhanced chemotaxis. The results support the hypothesis that drugs tested may modulate chemotactic function by affecting cellular microtubules assembly and/or GMPc accumulation.

Published
1982

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