1. p53 Codon 72 Polymorphism Interactions with Dietary and Tobacco Related Habits and Risk of Stomach Cancer in Mizoram, India
- Author
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Kanwar Narain, Sanjib Kumar Rajguru, Manab Deka, Tanvir Kaur, Jagadish Mahanta, Mridul Malakar, Rup Kumar Phukan, T Lalhmangaihi, Lalhriat Puia, K. Rekha Devi, Debajit Barua, and Lalrinliana Sailo
- Subjects
Male ,Cancer Research ,Alcohol Drinking ,Genotype ,Epidemiology ,India ,Physiology ,Biology ,Polymerase Chain Reaction ,Risk Factors ,Stomach Neoplasms ,Polymorphism (computer science) ,medicine ,Humans ,Gene–environment interaction ,Codon ,Stomach cancer ,Neoplasm Staging ,Genetics ,Polymorphism, Genetic ,Healthy population ,Smoking ,Public Health, Environmental and Occupational Health ,Case-control study ,Feeding Behavior ,Middle Aged ,Prognosis ,medicine.disease ,Increased risk ,Oncology ,Case-Control Studies ,Codon 72 polymorphism ,Female ,Gene-Environment Interaction ,Tumor Suppressor Protein p53 ,Polymorphism, Restriction Fragment Length ,Follow-Up Studies - Abstract
Background: This study was carried out to investigate the interaction of p53 codon 72 polymorphism, dietary and tobacco habits with reference to risk of stomach cancer in Mizoram, India. A total of 105 histologically confirmed stomach cancer cases and 210 age, sex and ethnicity matched healthy population controls were included in this study. Materials and Methods: The p53 codon 72 polymorphism was detected by PCR-RFLP and sequencing. H. pylori infection status was determined by ELISA. Information on various dietary and tobacco related habits was recorded with a standard questionnaire. Results: This study revealed that overall, the Pro/ Pro genotype was significantly associated with a higher risk of stomach cancer (OR, 2.54; 95%CI, 1.01-6.40) as compared to the Arg/Arg genotype. In gender stratified analysis, the Pro/Pro genotype showed higher risk (OR, 7.50; 95%CI, 1.20-47.0) than the Arg/Arg genotype among females. Similarly, the Pro/Pro genotype demonstrated higher risk of stomach cancer (OR, 6.30; 95%CI, 1.41-28.2) among older people (>60 years). However, no such associations were observed in males and in individuals
- Published
- 2014
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