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3. Effect of neutron-gamma radiation on dopamine and serotonin metabolism in the rat brain: a regional analysis.

Author

Foulon O, Lalouette F, Lambert F, Martin S, Fatôme M, and Martin C

Subjects
3,4-Dihydroxyphenylacetic Acid metabolism, Animals, Brain metabolism, Corpus Striatum radiation effects, Dose-Response Relationship, Radiation, Frontal Lobe radiation effects, Homovanillic Acid metabolism, Hydroxyindoleacetic Acid metabolism, Hypothalamus radiation effects, Male, Nucleus Accumbens radiation effects, Organ Specificity, Rats, Rats, Sprague-Dawley, Substantia Nigra radiation effects, Brain radiation effects, Dopamine metabolism, Gamma Rays, Neutrons, Serotonin metabolism
Abstract

The concentrations of dopamine (DA) and its metabolites and the levels of 5-hydroxyindoleacetic acid (5-HIAA), the metabolite of serotonin, were determined in discrete cerebral areas of rats 3 hr after (neutron-gamma) irradiation at 4 and 7 Gy. After the 7 Gy irradiation, no significant effect was observed. After the 4 Gy exposure, the most marked difference between irradiated and control rats was in the levels of DA and its metabolites in the striatum. We observed a decrease of DA, HVA, and DOPAC levels in the striatum and an opposite pattern in the substantia nigra. Whatever the brain area observed, an increase of 5-HIAA levels was noted.

Published
1999
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