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17 results on '"Lallemant, Jean-Gabriel"'

6. Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse

Author

Raynal Caroline, Chambon Guillaume, Chapuis Heliette, Combescure Christophe, Evrard Alexandre, Lallemant Benjamin, Reynaud Christophe, Sabra Omar, Joubert Dominique, Hollande Frédéric, Lallemant Jean-Gabriel, Lumbroso Serge, and Brouillet Jean-Paul

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Analysis of 23 published transcriptome studies allowed us to identify nine genes displaying frequent alterations in HNSCC (FN1, MMP1, PLAU, SPARC, IL1RN, KRT4, KRT13, MAL, and TGM3). We aimed to independently confirm these dysregulations and to identify potential relationships with clinical data for diagnostic, staging and prognostic purposes either at the tissue level or in saliva rinse. Methods For a period of two years, we systematically collected tumor tissue, normal matched mucosa and saliva of patients diagnosed with primary untreated HNSCC. Expression levels of the nine genes of interest were measured by RT-qPCR in tumor and healthy matched mucosa from 46 patients. MMP1 expression level was measured by RT-qPCR in the salivary rinse of 51 HNSCC patients and 18 control cases. Results Dysregulation of the nine genes was confirmed by the Wilcoxon test. IL1RN, MAL and MMP1 were the most efficient diagnostic markers of HNSCC, with ROC AUC > 0.95 and both sensitivity and specificity above 91%. No clinically relevant correlation was found between gene expression level in tumor and T stage, N stage, tumor grade, global survival or disease-free survival. Our preliminary results suggests that with 100% specificity, MMP1 detection in saliva rinse is potentially useful for non invasive diagnosis of HNSCC of the oral cavity or oropharynx, but technical improvement is needed since sensitivity was only 20%. Conclusion IL1RN, MAL and MMP1 are prospective tumor diagnostic markers for HNSCC. MMP1 overexpression is the most promising marker, and its detection could help identify tumor cells in tissue or saliva.

Published
2009
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9. Clinical relevance of nine transcriptional molecular markers for the diagnosis of head and neck squamous cell carcinoma in tissue and saliva rinse

Author

Lallemant, Benjamin, primary, Evrard, Alexandre, additional, Combescure, Christophe, additional, Chapuis, Heliette, additional, Chambon, Guillaume, additional, Raynal, Caroline, additional, Reynaud, Christophe, additional, Sabra, Omar, additional, Joubert, Dominique, additional, Hollande, Frédéric, additional, Lallemant, Jean-Gabriel, additional, Lumbroso, Serge, additional, and Brouillet, Jean-Paul, additional

Published
2009
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10. Reference gene selection for head and neck squamous cell carcinoma gene expression studies

Author

Lallemant, Benjamin, primary, Evrard, Alexandre, additional, Combescure, Christophe, additional, Chapuis, Heliette, additional, Chambon, Guillaume, additional, Raynal, Caroline, additional, Reynaud, Christophe, additional, Sabra, Omar, additional, Joubert, Dominique, additional, Hollande, Frédéric, additional, Lallemant, Jean-Gabriel, additional, Lumbroso, Serge, additional, and Brouillet, Jean-Paul, additional

Published
2009
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16. Early Maturation of Evoked Otoacoustic Emissions and Medial Olivocochlear Reflex in Preterm Neonates

Author

Chabert, René, Guitton, Matthieu J, Amram, Daniel, Uziel, Alain, Pujol, Rémy, Lallemant, Jean-Gabriel, and Puel, Jean-Luc

Abstract

The present study was designed to investigate the early maturation of the brainstem regulation of the cochlear function in preterm neonates. Evoked otoacoustic emissions (EOAE) and their regulation via the medial olivocochlear efferent (MOC) reflex were investigated in a large population of preterm neonates and compared with full-term neonates and young babies from birth to 4 y and school-aged children. In 28-wk preterm neonates, EOAE were seen in the mid-frequency range. These responses extended both to the low (down to 1025 Hz) and high (up to 6152 Hz) frequency ranges at 38 wk of gestational age and remained stable up to 4 mo. At this stage, the amplitude of EOAE overlapped adult values. EOAE amplitudes then decreased to reach adult values at 3 y of age. Maturation of MOC efferents innervating the outer hair cells was investigated by studying the suppressive effect of contralateral sound on the EOAE amplitudes (MOC reflex). The first MOC responses were recorded in preterm neonates of 32–33 wk of gestational age, reaching adult-like values at 37 wk of gestational age. The maximum effect of MOC efferent activation occurred between 2000 and 4000 Hz. These results suggest that, in humans, MOC efferents mature in utero. Thus, testing the MOC reflex may have a clinical relevance to detect an abnormal development of the auditory pathways, particularly of a brainstem circuitry not explored through conventional testing.

Published
2006
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17. A dual nodular thyroid ectopy, presenting with massive bleeding during pregnancy, treated by Sistrunk procedure.

Author

Reynaud C, Sabra O, Chambon G, Lallemant JG, and Lallemant B

Subjects
Adult, Choristoma complications, Choristoma pathology, Female, Humans, Hyoid Bone pathology, Oral Hemorrhage etiology, Oral Hemorrhage pathology, Pregnancy, Pregnancy Complications etiology, Pregnancy Complications pathology, Tongue Diseases complications, Tongue Diseases pathology, Treatment Outcome, Choristoma surgery, Hyoid Bone surgery, Oral Hemorrhage surgery, Otorhinolaryngologic Surgical Procedures methods, Pregnancy Complications surgery, Thyroid Gland, Tongue Diseases surgery
Published
2010
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