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335 results on '"Lalle, Eleonora"'

1. Role of Direct Sexual Contact in Human Transmission of Monkeypox Virus, Italy

Author

Sberna, Giuseppe, Rozera, Gabriella, Minosse, Claudia, Bordi, Licia, Mazzotta, Valentina, D'Abramo, Alessandra, Girardi, Enrico, Antinori, Andrea, Maggi, Fabrizio, and Lalle, Eleonora

Subjects
Human monkeypox -- Genetic aspects -- Diagnosis -- Care and treatment, Sexual intercourse -- Health aspects, Messenger RNA -- Health aspects, Disease transmission -- Genetic aspects, Health
Abstract

Monkeypox virus (MPXV) is the etiologic agent of zoonotic mpox disease. Although the virus was first discovered in colonies of monkeys kept for research in 1958, MPXV is mainly transmitted [...]

Published
2024
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3. Epidemiological impact of human adenovirus as causative agent of respiratory infections: An Italian multicentre retrospective study, 2022–2023

Author

Giardina, Federica A.M., Pellegrinelli, Laura, Novazzi, Federica, Vian, Elisa, Biscaro, Valeria, Russo, Cristina, Ranno, Stefania, Pagani, Elisabetta, Masi, Elisa, Tiberio, Claudia, Esposito, Martina, Uceda Renteria, Sara, Callegaro, Annapaola, Piccirilli, Giulia, Lazzarotto, Tiziana, Rovida, Francesca, Galli, Cristina, Lalle, Eleonora, Maggi, Fabrizio, Mancini, Nicasio, Acciarri, Carla, Menzo, Stefano, Colacicco, Anna Maria, Scarasciulli, Maria, Piralla, Antonio, Baldanti, Fausto, and Pariani, Elena

Published
2024
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4. On the lookout for influenza viruses in Italy during the 2021-2022 season: Along came A(H3N2) viruses with a new phylogenetic makeup of their hemagglutinin

Author

Galli, Cristina, Pellegrinelli, Laura, Giardina, Federica, Ferrari, Guglielmo, Uceda Renteria, Sara Colonia, Novazzi, Federica, Masi, Elisa, Pagani, Elisabetta, Piccirilli, Giulia, Mauro, Maria Vittoria, Binda, Sandro, Corvaro, Benedetta, Tiberio, Claudia, Lalle, Eleonora, Maggi, Fabrizio, Russo, Cristina, Ranno, Stefania, Vian, Elisa, Pariani, Elena, Baldanti, Fausto, and Piralla, Antonio

Published
2023
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5. SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis

Author

Mastrorosa, Ilaria, Cozzi-Lepri, Alessandro, Colavita, Francesca, Lalle, Eleonora, Mazzotta, Valentina, Cimaglia, Claudia, Paulicelli, Jessica, Matusali, Giulia, Fabeni, Lavinia, Carletti, Fabrizio, Rosati, Silvia, Vita, Serena, Giannico, Giuseppina, Piselli, Pierluca, Biliotti, Elisa, Moghazi, Samir Al, Mosti, Silvia, Girardi, Enrico, Nicastri, Emanuele, Garbuglia, Anna Rosa, Maggi, Fabrizio, Vaia, Francesco, and Antinori, Andrea

Published
2022
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7. Autochthonous Dengue Fever in 2 Patients, Rome, Italy

Author

Vita, Serena, Bordi, Licia, Sberna, Giuseppe, Caputi, Priscilla, Lapa, Daniele, Corpolongo, Angela, Mija, Cosmina, D'Abramo, Alessandra, Maggi, Fabrizio, Vairo, Francesco, Specchiarello, Eliana, Girardi, Enrico, Lalle, Eleonora, and Nicastri, Emanuele

Subjects
Aedes albopictus -- Health aspects, Dengue -- Health aspects, Infection -- Health aspects, Travelers -- Health aspects, Disease transmission -- Health aspects, Health
Abstract

Dengue virus (DENV) infection is the most prevalent arthropodborne viral disease in humans, caused by 4 DENV serotypes widely spread in tropical and subtropical regions and transmitted mainly by Aedes [...]

Published
2024

8. Infectious Toscana Virus in Seminal Fluid of Young Man Returning from Elba Island, Italy

Author

Matusali, Giulia, D'Abramo, Alessandra, Terrosi, Chiara, Carletti, Fabrizio, Colavita, Francesca, Vairo, Francesco, Savellini, Gianni Gori, Gandolfo, Claudia, Anichini, Gabriele, Lalle, Eleonora, Bordi, Licia, Corpolongo, Angela, Maritti, Micaela, Marchioni, Luisa, Capobianchi, Maria Rosaria, Castilletti, Concetta, Cusi, Maria Grazia, and Nicastri, Emanuele

Subjects
Semen -- Case studies -- Health aspects, Bunyaviruses -- Case studies -- Identification and classification, RNA virus infections -- Case studies -- Risk factors -- Diagnosis, Viral meningitis -- Case studies -- Risk factors -- Diagnosis, Health
Abstract

Toscana virus (TOSV) is an arthropodborne virus, belonging to the genus Phlebovirus, that was first isolated in Monte Argentario in 1971 from the sand flies Phlebotomus perniciosus and P. perfiliewi [...]

Published
2022
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9. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Abbonizio, Maria Alessandra, Abdeddaim, Amina, Agostini, Elisabetta, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonica, Maria Assunta, Antonini, Mario, Bartoli, Tommaso Ascoli, Baldini, Francesco, Barbaro, Raffaella, Bartolini, Barbara, Bellagamba, Rita, Benigni, Martina, Bevilacqua, Nazario, Biava, Gianluigi, Bibas, Michele, Bordi, Licia, Bordoni, Veronica, Boumis, Evangelo, Branca, Marta, Buonomo, Rosanna, Busso, Donatella, Camici, Marta, Campioni, Paolo, Canichella, Flaminia, Capobianchi, Maria Rosaria, Capone, Alessandro, Caporale, Cinzia, Caraffa, Emanuela, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Cataldo, Adriana, Cerilli, Stefano, Cerva, Carlotta, Chiappini, Roberta, Chinello, Pierangelo, Cianfarani, Maria Assunta, Ciaralli, Carmine, Cimaglia, Claudia, Cinicola, Nicola, Ciotti, Veronica, Cicalini, Stefania, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, De Palo, Maria Grazia, De Zottis, Federico, Di Bari, Virginia, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Donno, Davide, Evangelista, Francesca, Faraglia, Francesca, Farina, Anna, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Fusetti, Matteo, Galati, Vincenzo, Gagliardini, Roberta, Gallì, Paola, Garotto, Gabriele, Gaviano, Ilaria, Tekle, Saba Gebremeskel, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Granata, Guido, Greci, Maria Cristina, Grilli, Elisabetta, Grisetti, Susanna, Gualano, Gina, Iacomi, Fabio, Iaconi, Marta, Iannicelli, Giuseppina, Inversi, Carlo, Ippolito, Giuseppe, Lalle, Eleonora, Lamanna, Maria Elena, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Libertone, Raffaella, Lionetti, Raffaella, Liuzzi, Giuseppina, Loiacono, Laura, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Maffongelli, Gaetano, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Mastrobattista, Annelisa, Mastrorosa, Ilaria, Matusali, Giulia, Mazzotta, Valentina, Mencarini, Paola, Meschi, Silvia, Messina, Francesco, Micarelli, Sibiana, Mogavero, Giulia, Mondi, Annalisa, Montalbano, Marzia, Montaldo, Chiara, Mosti, Silvia, Murachelli, Silvia, Musso, Maria, Nardi, Michela, Navarra, Assunta, Nicastri, Emanuele, Nocioni, Martina, Noto, Pasquale, Noto, Roberto, Oliva, Alessandra, Onnis, Ilaria, Ottou, Sandrine, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Palombi, Giulio, Pareo, Carlo, Passeri, Virgilio, Pelliccioni, Federico, Penna, Giovanna, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pinnetti, Carmela, Pisciotta, Maria, Piselli, Pierluca, Pittalis, Silvia, Pontarelli, Agostina, Proietti, Costanza, Puro, Vincenzo, Ramazzini, Paolo Migliorisi, Rianda, Alessia, Rinonapoli, Gabriele, Rosati, Silvia, Rubino, Dorotea, Rueca, Martina, Ruggeri, Alberto, Sacchi, Alessandra, Sampaolesi, Alessandro, Sanasi, Francesco, Santagata, Carmen, Scarabello, Alessandra, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Strano, Giacomo, Taglietti, Fabrizio, Taibi, Chiara, Taloni, Giorgia, Nardi, Tetaj, Tonnarini, Roberto, Topino, Simone, Tozzi, Martina, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Vergori, Alessandra, Vincenzi, Laura, Visco-Comandini, Ubaldo, Vita, Serena, Vittozzi, Pietro, Zaccarelli, Mauro, Zanetti, Antonella, Zito, Sara, Lorenzini, Patrizia, Di Gennaro, Francesco, and Girardi, Enrico

Published
2021
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10. Saliva Is a Sensitive and Accessible Sample Both for SARS-CoV-2 Detection and for the Evaluation of Treatment Effectiveness in Follow-Up Studies.

Author

Lalle, Eleonora, Mazzotta, Valentina, Sberna, Giuseppe, Fabeni, Lavinia, Garbuglia, Anna Rosa, Mastrorosa, Ilaria, D'Abramo, Alessandra, Nicastri, Emanuele, Girardi, Enrico, Antinori, Andrea, Maggi, Fabrizio, and Bordi, Licia

Subjects
*TREATMENT effectiveness, *SALIVA analysis, *DRUG efficacy, *COVID-19 testing, *SALIVA
Abstract

Despite emerging evidence indicating that molecular SARS-CoV-2 tests performed on saliva have diagnostic sensitivity and specificity comparable to those observed with nasopharyngeal swabs (NPSs), most in vivo follow-up studies on the efficacy of drugs against SARS-CoV-2 have been performed on NPSs, not considering saliva as a possible alternative matrix. For this reason, in this study, we used, in parallel, saliva and NPS samples for the detection of SARS-CoV-2 by real-time RT-PCR in patients receiving Tixagevimab/Cilgavimab, Nirmatrelvir/Ritonavir, or Sotrovimab as a treatment against SARS-CoV-2. Our results showed a good correlation between the NPS and saliva samples for each drug; moreover, comparable changes in the cycle threshold (Ct) levels in saliva and NPSs were observed both 7 days and 30 days after treatment, thus confirming that the saliva represents a good matrix for in vivo follow-up studies verifying the effectiveness of treatments against SARS-CoV-2. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Rapid Determination of SARS-CoV-2 Integrity and Infectivity by Using Propidium Monoazide Coupled with Digital Droplet PCR.

Author

Sberna, Giuseppe, Mija, Cosmina, Lalle, Eleonora, Rozera, Gabriella, Matusali, Giulia, Carletti, Fabrizio, Girardi, Enrico, and Maggi, Fabrizio

Subjects
PROPIDIUM monoazide, SARS-CoV-2, VIRAL load, COVID-19 pandemic, CIRCULATING tumor DNA
Abstract

SARS-CoV-2 is a highly infectious virus responsible for the COVID-19 pandemic. Therefore, it is important to assess the risk of SARS-CoV-2 infection, especially in persistently positive patients. Rapid discrimination between infectious and non-infectious viruses aids in determining whether prevention, control, and treatment measures are necessary. For this purpose, a method was developed and utilized involving a pre-treatment with 50 µM of propidium monoazide (PMAxx, a DNA intercalant) combined with a digital droplet PCR (ddPCR). The ddPCR method was performed on 40 nasopharyngeal swabs (NPSs) both before and after treatment with PMAxx, revealing a reduction in the viral load at a mean of 0.9 Log copies/mL (SD ± 0.6 Log copies/mL). Furthermore, six samples were stratified based on the Ct values of SARS-CoV-2 RNA (Ct < 20, 20 < Ct < 30, Ct > 30) and analyzed to compare the results obtained via a ddPCR with viral isolation and a negative-chain PCR. Of the five samples found positive via a ddPCR after the PMAxx treatment, two of the samples showed the highest post-treatment SARS-CoV-2 loads. The virus was isolated in vitro from both samples and the negative strand chains were detected. In three NPS samples, SARS CoV-2 was present post-treatment at a low level; it was not isolated in vitro, and, when detected, the strand was negative. Our results indicate that the established method is useful for determining whether the SARS-CoV-2 within positive NPS samples is intact and capable of causing infection. [ABSTRACT FROM AUTHOR]

Published
2024
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14. 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation

Author

Abbonizio, Maria Alessandra, Agrati, Chiara, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Castilletti, Concetta, Chiappini, Roberta, Ciaralli, Carmine, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, Angelis, Alessia De, Angelis, Giada De, Lorenzo, Rachele Di, Stefano, Federica Di, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Greci, Maria Cristina, Ippolito, Giuseppe, Lalle, Eleonora, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Marchioni, Luisa, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Montaldo, Francesco Messina Chiara, Murachelli, Silvia, Nicastri, Emanuele, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Scorzolini, Laura, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, Valli, Maria Beatrice, Di Stefano, Federica, Eskild, Petersen, and Zumla, Alimuddin

Published
2020
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16. In Vitro and In Vivo Crosstalk between Type I IFN and IL-8 Responses in SARS-CoV-2 Infection

Author

Biava, Mirella, primary, Notari, Stefania, additional, Grassi, Germana, additional, Bordi, Licia, additional, Tartaglia, Eleonora, additional, Agrati, Chiara, additional, Cimini, Eleonora, additional, Sberna, Giuseppe, additional, Nicastri, Emanuele, additional, Antinori, Andrea, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, Maggi, Fabrizio, additional, and Lalle, Eleonora, additional

Published
2023
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17. Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

Author

Agrati, Chiara, Sacchi, Alessandra, Bordoni, Veronica, Cimini, Eleonora, Notari, Stefania, Grassi, Germana, Casetti, Rita, Tartaglia, Eleonora, Lalle, Eleonora, D’Abramo, Alessandra, Castilletti, Concetta, Marchioni, Luisa, Shi, Yufang, Mariano, Andrea, Song, Jin-Wen, Zhang, Ji-Yuan, Wang, Fu-Sheng, Zhang, Chao, Fimia, Gian Maria, Capobianchi, Maria R., Piacentini, Mauro, Antinori, Andrea, Nicastri, Emanuele, Maeurer, Markus, Zumla, Alimuddin, and Ippolito, Giuseppe

Published
2020
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18. SARS-CoV-2 Phylogenetic Analysis, Lazio Region, Italy, February-March 2020

Author

Bartolini, Barbara, Rueca, Martina, Gruber, Cesare Ernesto Maria, Messina, Francesco, Carletti, Fabrizio, Giombini, Emanuela, Lalle, Eleonora, Bordi, Licia, Matusali, Giulia, Colavita, Francesca, Castilletti, Concetta, Vairo, Francesco, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, and Caro, Antonino Di

Subjects
Severe acute respiratory syndrome -- Health aspects -- Analysis, Coronaviruses -- Analysis -- Health aspects, Phylogeny -- Analysis -- Health aspects, Epidemiology -- Analysis -- Health aspects, COVID-19 -- Analysis -- Health aspects, Health
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised serious concerns because of its rapid dissemination worldwide. Italy is one of the countries with the highest number of coronavirus disease [...]

Published
2020
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20. Emerging Zika Virus Infection: A Rapidly Evolving Situation

Author

Bordi, Licia, Avsic-Zupanc, Tatjana, Lalle, Eleonora, Vairo, Francesco, Rosaria Capobianchi, Maria, da Costa Vasconcelos, Pedro Fernando, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Rezza, Giovanni, editor, and Ippolito, Giuseppe, editor

Published
2017
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23. Comparison of SARS-CoV-2 Detection in Nasopharyngeal Swab and Saliva Samples from Patients Infected with Omicron Variant

Author

Bordi, Licia, primary, Sberna, Giuseppe, additional, Lalle, Eleonora, additional, Fabeni, Lavinia, additional, Mazzotta, Valentina, additional, Lanini, Simone, additional, Corpolongo, Angela, additional, Garbuglia, Anna Rosa, additional, Nicastri, Emanuele, additional, Girardi, Enrico, additional, Vaia, Francesco, additional, Antinori, Andrea, additional, and Maggi, Fabrizio, additional

Published
2023
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25. Passengers screening for SARS-CoV-2 infection at Rome Fiumicino Airport: a strategy aimed at limiting the spreading of the infection through COVID-free air flights revealed the airport role as a formidable sentinel center for monitoring pandemic trends and viral variants circulation

Author

Amendola, Alessandra, primary, Minosse, Claudia, additional, Carletti, Fabrizio, additional, Specchiarello, Elena, additional, Lalle, Eleonora, additional, Bordi, Licia, additional, Castilletti, Concetta, additional, Forbici, Federica, additional, Pisciotta, Maria, additional, Rossi, Fabrizio, additional, Scarparo, Tiziano, additional, Garbuglia, Anna Rosa, additional, and Vaia, Francesco, additional

Published
2022
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27. Molecular Characterization of Autochthonous Chikungunya Cluster in Latium Region, Italy

Author

Bordi, Licia, Carletti, Fabrizio, Lalle, Eleonora, Colavita, Francesca, Meschi, Silvia, Caro, Antonino Di, Nicastri, Emanuele, Scognamiglio, Paola, Vairo, Francesco, Lallo, Domenico Di, Panella, Vincenzo, Capobianchi, Maria R., Ippolito, Giuseppe, and Castilletti, Concetta

Subjects
Mosquitoes -- Health aspects, Epidemics -- Health aspects, Infection -- Health aspects, Health
Abstract

Local transmission of chikungunya virus (CHIKV) has been confirmed in the Lazio region of Italy, with 2 related autochthonous clusters in the cities of Anzio and Rome (1). This event [...]

Published
2018
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29. Erratum: Emerging Zika Virus Infection: A Rapidly Evolving Situation

Author

Bordi, Licia, Avsic-Zupanc, Tatjana, Lalle, Eleonora, Vairo, Francesco, Rosaria Capobianchi, Maria, da Costa Vasconcelos, Pedro Fernando, COHEN, IRUN R., Series editor, LAJTHA, ABEL, Series editor, LAMBRIS, JOHN D., Series editor, PAOLETTI, RODOLFO, Series editor, Rezza, Giovanni, editor, and Ippolito, Giuseppe, editor

Published
2017
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31. Emulation of a Target Trial From Observational Data to Compare Effectiveness of Casirivimab/Imdevimab and Bamlanivimab/Etesevimab for Early Treatment of Non-Hospitalized Patients With COVID-19

Author

Mazzotta, Valentina, primary, Cozzi-Lepri, Alessandro, additional, Colavita, Francesca, additional, Lanini, Simone, additional, Rosati, Silvia, additional, Lalle, Eleonora, additional, Mastrorosa, Ilaria, additional, Cimaglia, Claudia, additional, Vergori, Alessandra, additional, Bevilacqua, Nazario, additional, Lapa, Daniele, additional, Mariano, Andrea, additional, Bettini, Aurora, additional, Agrati, Chiara, additional, Piselli, Pierluca, additional, Girardi, Enrico, additional, Castilletti, Concetta, additional, Garbuglia, Anna Rosa, additional, Vaia, Francesco, additional, Nicastri, Emanuele, additional, and Antinori, Andrea, additional

Published
2022
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33. Measles cases during Ebola outbreak, West Africa, 2013-2106

Author

Colavita, Francesca, Biava, Mirella, Castilletti, Concetta, Quartu, Serena, Vairo, Francesco, Caglioti, Claudia, Agrati, Chiara, Lalle, Eleonora, Bordi, Licia, Lanini, Simone, Guanti, Michela Delli, Miccio, Rossella, Ippolito, Giuseppe, Capobianchi, Maria R., and Di Caro, Antonino

Subjects
Ebola hemorrhagic fever -- Risk factors, Epidemics -- Research, Health
Abstract

The Ebola virus disease (EVD) outbreak in West Africa during 2013-2016 was one of the worst public health disasters in recent history; it caused >28,646 cases and 11,323 deaths (1). [...]

Published
2017
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35. Virological and Serological Characterisation of SARS-CoV-2 Infections Diagnosed After mRNA BNT162b2 Vaccination Between December 2020 and March 2021

Author

Colavita, Francesca, primary, Meschi, Silvia, additional, Gruber, Cesare Ernesto Maria, additional, Rueca, Martina, additional, Vairo, Francesco, additional, Matusali, Giulia, additional, Lapa, Daniele, additional, Giombini, Emanuela, additional, De Carli, Gabriella, additional, Spaziante, Martina, additional, Messina, Francesco, additional, Bonfiglio, Giulia, additional, Carletti, Fabrizio, additional, Lalle, Eleonora, additional, Fabeni, Lavinia, additional, Berno, Giulia, additional, Puro, Vincenzo, additional, Bartolini, Barbara, additional, Di Caro, Antonino, additional, Ippolito, Giuseppe, additional, Capobianchi, Maria Rosaria, additional, and Castilletti, Concetta, additional

Published
2022
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36. SARS-CoV-2 Nasopharyngeal Viral Load in Individuals Infected with BA.2, Compared to Alpha, Gamma, Delta and BA.1 Variants: A Single-Center Comparative Analysis

Author

Mastrorosa, Ilaria, primary, Lepri, Alessandro Cozzi, additional, Colavita, Francesca, additional, Lalle, Eleonora, additional, Mazzotta, Valentina, additional, Cimaglia, Claudia, additional, Paulicelli, Jessica, additional, Matusali, Giulia, additional, Fabeni, Lavinia, additional, Carletti, Fabrizio, additional, Rosati, Silvia, additional, Vita, Serena, additional, Giannico, Giuseppina, additional, Piselli, Pierluca, additional, Biliotti, Elisa, additional, Al Moghazi, Samir, additional, Mosti, Silvia, additional, Girardi, Enrico, additional, Nicastri, Emanuele, additional, Garbuglia, Anna Rosa, additional, Maggi, Fabrizio, additional, Vaia, Francesco, additional, and Antinori, Andrea, additional

Published
2022
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37. Measles in Italy: Co-circulation of B3 variants during 2014

Author

Magurano, Fabio, Baggieri, Melissa, Bordi, Licia, Lalle, Eleonora, Chironna, Maria, Lazzarotto, Tiziana, Amendola, Antonella, Baldanti, Fausto, Ansaldi, Filippo, Filia, Antonietta, Declich, Silvia, Iannazzo, Stefania, Pompa, Maria Grazia, Bucci, Paola, Marchi, Antonella, and Nicoletti, Loredana

Published
2016
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38. Viral load decrease in SARS‐CoV‐2 BA.1 and BA.2 Omicron sublineages infection after treatment with monoclonal antibodies and direct antiviral agents.

Author

Mazzotta, Valentina, Cozzi Lepri, Alessandro, Colavita, Francesca, Rosati, Silvia, Lalle, Eleonora, Cimaglia, Claudia, Paulicelli, Jessica, Mastrorosa, Ilaria, Vita, Serena, Fabeni, Lavinia, Vergori, Alessandra, Maffongelli, Gaetano, Carletti, Fabrizio, Lanini, Simone, Caraffa, Emanuela, Milozzi, Eugenia, Libertone, Raffaella, Piselli, Pierluca, Girardi, Enrico, and Garbuglia, AnnaRosa

Subjects
ANTIVIRAL agents, MONOCLONAL antibodies, SARS-CoV-2 Omicron variant, VIRAL load, SARS-CoV-2
Abstract

The efficacy on the Omicron variant of the approved early coronavirus disease‐2019 (COVID‐19) therapies, especially monoclonal antibodies, has been challenged by in vitro neutralization data, while data on in vivo antiviral activity are lacking. We assessed potential decrease from Day 1 to Day 7 viral load (VL) in nasopharyngeal swabs of outpatients receiving Sotrovimab, Molnupiravir, Remdesivir, or Nirmatrelvir/ritonavir for mild‐to‐moderate COVID‐19 due to sublineages BA.1 or BA.2, and average treatment effect by weighted marginal linear regression models. A total of 521 patients (378 BA.1 [73%], 143 [27%] BA.2) received treatments (Sotrovimab 202, Molnupiravir 117, Nirmatrelvir/ritonavir 84, and Remdesivir 118): median age 66 years, 90% vaccinated, median time from symptoms onset 3 days. Day 1 mean VL was 4.12 log2 (4.16 for BA.1 and 4.01 for BA.2). The adjusted analysis showed that Nirmatrelvir/ritonavir significantly reduced VL compared to all the other drugs, except versus Molnupiravir in BA.2. Molnupiravir was superior to Remdesivir in both BA.1 and BA.2, and to Sotrovimab in BA.2. Sotrovimab had better activity than Remdesivir only against BA.1. Nirmatrelvir/ritonavir showed the greatest antiviral activity against Omicron variant, comparable to Molnupiravir only in the BA.2 subgroup. VL decrease could be a valuable surrogate of drug activity in the context of the high prevalence of vaccinated people and low probability of hospital admission. [ABSTRACT FROM AUTHOR]

Published
2023
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40. Virological and Serological Characterization of SARS-CoV-2 Infections Diagnosed After mRNA BNT162b2 Vaccination

Author

Colavita, Francesca, primary, Meschi, Silvia, additional, Maria Gruber, Cesare Ernesto, additional, Rueca, Martina, additional, Vairo, Francesco, additional, Matusali, Giulia, additional, Lapa, Daniele, additional, Giombini, Emanuela, additional, Carli, Gabriella De, additional, Spaziante, Martina, additional, Messina, Francesco, additional, Bonfiglio, Giulia, additional, Carletti, Fabrizio, additional, Lalle, Eleonora, additional, Fabeni, Lavinia, additional, Berno, Giulia, additional, Puro, Vincenzo, additional, Caro, Antonino Di, additional, Bartolini, Barbara, additional, Ippolito, Giuseppe, additional, Capobianchi, Maria Rosaria, additional, and Castilletti, Concetta, additional

Published
2021
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44. Lumipulse G SARS-CoV-2 Ag assay evaluation using clinical samples from different testing groups

Author

Menchinelli, Giulia, primary, Bordi, Licia, additional, Liotti, Flora Marzia, additional, Palucci, Ivana, additional, Capobianchi, Maria Rosaria, additional, Sberna, Giuseppe, additional, Lalle, Eleonora, additional, Romano, Lucio, additional, De Angelis, Giulia, additional, Marchetti, Simona, additional, Sanguinetti, Maurizio, additional, Cattani, Paola, additional, and Posteraro, Brunella, additional

Published
2021
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45. Risk and predictive factors of prolonged viral RNA shedding in upper respiratory specimens in a large cohort of COVID-19 patients admitted to an Italian reference hospital

Author

Mondi, Annalisa, primary, Lorenzini, Patrizia, additional, Castilletti, Concetta, additional, Gagliardini, Roberta, additional, Lalle, Eleonora, additional, Corpolongo, Angela, additional, Valli, Maria Beatrice, additional, Taglietti, Fabrizio, additional, Cicalini, Stefania, additional, Loiacono, Laura, additional, Di Gennaro, Francesco, additional, D’Offizi, Gianpiero, additional, Palmieri, Fabrizio, additional, Nicastri, Emanuele, additional, Agrati, Chiara, additional, Petrosillo, Nicola, additional, Ippolito, Giuseppe, additional, Vaia, Francesco, additional, Girardi, Enrico, additional, Capobianchi, Maria Rosaria, additional, Antinori, Andrea, additional, Zito, Sara, additional, Abbonizio, Maria Alessandra, additional, Abdeddaim, Amina, additional, Agostini, Elisabetta, additional, Albarello, Fabrizio, additional, Amadei, Gioia, additional, Amendola, Alessandra, additional, Antonica, Maria Assunta, additional, Antonini, Mario, additional, Bartoli, Tommaso Ascoli, additional, Baldini, Francesco, additional, Barbaro, Raffaella, additional, Bartolini, Barbara, additional, Bellagamba, Rita, additional, Benigni, Martina, additional, Bevilacqua, Nazario, additional, Biava, Gianluigi, additional, Bibas, Michele, additional, Bordi, Licia, additional, Bordoni, Veronica, additional, Boumis, Evangelo, additional, Branca, Marta, additional, Buonomo, Rosanna, additional, Busso, Donatella, additional, Camici, Marta, additional, Campioni, Paolo, additional, Canichella, Flaminia, additional, Capone, Alessandro, additional, Caporale, Cinzia, additional, Caraffa, Emanuela, additional, Caravella, Ilaria, additional, Carletti, Fabrizio, additional, Cataldo, Adriana, additional, Cerilli, Stefano, additional, Cerva, Carlotta, additional, Chiappini, Roberta, additional, Chinello, Pierangelo, additional, Cianfarani, Maria Assunta, additional, Ciaralli, Carmine, additional, Cimaglia, Claudia, additional, Cinicola, Nicola, additional, Ciotti, Veronica, additional, Colavita, Francesca, additional, Cristofaro, Massimo, additional, Curiale, Salvatore, additional, D’Abramo, Alessandra, additional, Dantimi, Cristina, additional, De Angelis, Alessia, additional, De Angelis, Giada, additional, De Palo, Maria Grazia, additional, De Zottis, Federico, additional, Di Bari, Virginia, additional, Di Lorenzo, Rachele, additional, Di Stefano, Federica, additional, Donno, Davide, additional, Evangelista, Francesca, additional, Faraglia, Francesca, additional, Farina, Anna, additional, Ferraro, Federica, additional, Fiorentini, Lorena, additional, Frustaci, Andrea, additional, Fusetti, Matteo, additional, Galati, Vincenzo, additional, Gallì, Paola, additional, Garotto, Gabriele, additional, Gaviano, Ilaria, additional, Tekle, Saba Gebremeskel, additional, Giancola, Maria Letizia, additional, Giansante, Filippo, additional, Giombini, Emanuela, additional, Granata, Guido, additional, Greci, Maria Cristina, additional, Grilli, Elisabetta, additional, Grisetti, Susanna, additional, Gualano, Gina, additional, Iacomi, Fabio, additional, Iaconi, Marta, additional, Iannicelli, Giuseppina, additional, Inversi, Carlo, additional, Lamanna, Maria Elena, additional, Lanini, Simone, additional, Lapa, Daniele, additional, Lepore, Luciana, additional, Libertone, Raffaella, additional, Lionetti, Raffaella, additional, Liuzzi, Giuseppina, additional, Lucia, Andrea, additional, Lufrani, Franco, additional, Macchione, Manuela, additional, Maffongelli, Gaetano, additional, Marani, Alessandra, additional, Marchioni, Luisa, additional, Mariano, Andrea, additional, Marini, Maria Cristina, additional, Maritti, Micaela, additional, Mastrobattista, Annelisa, additional, Mastrorosa, Ilaria, additional, Matusali, Giulia, additional, Mazzotta, Valentina, additional, Mencarini, Paola, additional, Meschi, Silvia, additional, Messina, Francesco, additional, Micarelli, Sibiana, additional, Mogavero, Giulia, additional, Mondi, Annalisa, additional, Montalbano, Marzia, additional, Montaldo, Chiara, additional, Mosti, Silvia, additional, Murachelli, Silvia, additional, Musso, Maria, additional, Nardi, Michela, additional, Navarra, Assunta, additional, Nocioni, Martina, additional, Noto, Pasquale, additional, Noto, Roberto, additional, Oliva, Alessandra, additional, Onnis, Ilaria, additional, Ottou, Sandrine, additional, Palazzolo, Claudia, additional, Pallini, Emanuele, additional, Palombi, Giulio, additional, Pareo, Carlo, additional, Passeri, Virgilio, additional, Pelliccioni, Federico, additional, Penna, Giovanna, additional, Petrecchia, Antonella, additional, Petrone, Ada, additional, Pianura, Elisa, additional, Pinnetti, Carmela, additional, Pisciotta, Maria, additional, Piselli, Pierluca, additional, Pittalis, Silvia, additional, Pontarelli, Agostina, additional, Proietti, Costanza, additional, Puro, Vincenzo, additional, Ramazzini, Paolo Migliorisi, additional, Rianda, Alessia, additional, Rinonapoli, Gabriele, additional, Rosati, Silvia, additional, Rubino, Dorotea, additional, Rueca, Martina, additional, Ruggeri, Alberto, additional, Sacchi, Alessandra, additional, Sampaolesi, Alessandro, additional, Sanasi, Francesco, additional, Santagata, Carmen, additional, Scarabello, Alessandra, additional, Scarcia, Silvana, additional, Schininà, Vincenzo, additional, Scognamiglio, Paola, additional, Scorzolini, Laura, additional, Stazi, Giulia, additional, Strano, Giacomo, additional, Taibi, Chiara, additional, Taloni, Giorgia, additional, Nardi, Tetaj, additional, Tonnarini, Roberto, additional, Topino, Simone, additional, Tozzi, Martina, additional, Vairo, Francesco, additional, Vergori, Alessandra, additional, Vincenzi, Laura, additional, Visco-Comandini, Ubaldo, additional, Vita, Serena, additional, Vittozzi, Pietro, additional, Zaccarelli, Mauro, additional, and Zanetti, Antonella, additional

Published
2021
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46. COVID-19 Rapid Antigen Test as Screening Strategy at Points of Entry: Experience in Lazio Region, Central Italy, August–October 2020

Author

Colavita, Francesca, primary, Vairo, Francesco, additional, Meschi, Silvia, additional, Valli, Maria Beatrice, additional, Lalle, Eleonora, additional, Castilletti, Concetta, additional, Fusco, Danilo, additional, Spiga, Giuseppe, additional, Bartoletti, Pierluigi, additional, Ursino, Simona, additional, Sanguinetti, Maurizio, additional, Di Caro, Antonino, additional, Vaia, Francesco, additional, Ippolito, Giuseppe, additional, and Capobianchi, Maria Rosaria, additional

Published
2021
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47. Performance of a novel diagnostic assay for rapid SARS-CoV-2 antigen detection in nasopharynx samples

Author

Liotti, Flora Marzia, primary, Menchinelli, Giulia, additional, Lalle, Eleonora, additional, Palucci, Ivana, additional, Marchetti, Simona, additional, Colavita, Francesca, additional, La Sorda, Marilena, additional, Sberna, Giuseppe, additional, Bordi, Licia, additional, Sanguinetti, Maurizio, additional, Cattani, Paola, additional, Capobianchi, Maria Rosaria, additional, and Posteraro, Brunella, additional

Published
2021
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48. Dermatological manifestations during COVID‐19 and histological picture: Description of two clinical cases

Author

Mencarini, Paola, primary, Scarabello, Alessandra, additional, Del Nonno, Franca, additional, Lalle, Eleonora, additional, Falasca, Laura, additional, Gualano, Gina, additional, Nardacci, Roberta, additional, Mosti, Silvia, additional, Musso, Maria, additional, Libertone, Raffaella, additional, Di Bari, Virginia, additional, Rosati, Silvia, additional, Colombo, Daniele, additional, Castilletti, Concetta, additional, and Palmieri, Fabrizio, additional

Published
2021
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49. SARS-CoV-2 Early Screening at the Point of Entry: Travelers From Bangladesh to Italy–July 2020

Author

Rueca, Martina, primary, Di Caro, Antonino, additional, Gruber, Cesare Ernesto Maria, additional, Messina, Francesco, additional, Giombini, Emanuela, additional, Valli, Maria Beatrice, additional, Lalle, Eleonora, additional, Lanini, Simone, additional, Vairo, Francesco, additional, Capobianchi, Maria Rosaria, additional, and Bartolini, Barbara, additional

Published
2021
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50. Pharmacokinetics of remdesivir and GS-441524 in two critically ill patients who recovered from COVID-19

Author

Tempestilli, Massimo, Caputi, Priscilla, Avataneo, Valeria, Notari, Stefania, Forini, Olindo, Scorzolini, Laura, Marchioni, Luisa, Ascoli Bartoli, Tommaso, Castilletti, Concetta, Lalle, Eleonora, Capobianchi, Maria R, Nicastri, Emanuele, D’Avolio, Antonio, Ippolito, Giuseppe, Agrati, Chiara, Abbonizio, Maria Alessandra, Albarello, Fabrizio, Amadei, Gioia, Amendola, Alessandra, Antinori, Andrea, Antonini, Mario, Barbaro, Raffaella, Bartolini, Barbara, Benigni, Martina, Bevilacqua, Nazario, Bordi, Licia, Bordoni, Veronica, Branca, Marta, Campioni, Paolo, Capobianchi, Maria Rosaria, Caporale, Cinzia, Caravella, Ilaria, Carletti, Fabrizio, Casetti, Rita, Chiappini, Roberta, Ciaralli, Carmine, Cimini, Eleonora, Colavita, Francesca, Corpolongo, Angela, Cristofaro, Massimo, Curiale, Salvatore, D’Abramo, Alessandra, Dantimi, Cristina, De Angelis, Alessia, De Angelis, Giada, Di Lorenzo, Rachele, Di Stefano, Federica, D’Offizi, Gianpiero, Ferraro, Federica, Fiorentini, Lorena, Frustaci, Andrea, Gallì, Paola, Garotto, Gabriele, Giancola, Maria Letizia, Giansante, Filippo, Giombini, Emanuela, Grassi, Germana, Greci, Maria Cristina, Lanini, Simone, Lapa, Daniele, Lepore, Luciana, Lucia, Andrea, Lufrani, Franco, Macchione, Manuela, Marani, Alessandra, Mariano, Andrea, Marini, Maria Cristina, Maritti, Micaela, Matusali, Giulia, Meschi, Silvia, Messina, Francesco, Montaldo, Chiara, Murachelli, Silvia, Noto, Roberto, Palazzolo, Claudia, Pallini, Emanuele, Palmieri, Fabrizio, Passeri, Virgilio, Pelliccioni, Federico, Petrecchia, Antonella, Petrone, Ada, Petrosillo, Nicola, Pianura, Elisa, Pisciotta, Maria, Pittalis, Silvia, Proietti, Costanza, Puro, Vincenzo, Rinonapoli, Gabriele, Rueca, Martina, Sacchi, Alessandra, Sanasi, Francesco, Santagata, Carmen, Scarcia, Silvana, Schininà, Vincenzo, Scognamiglio, Paola, Stazi, Giulia, Vaia, Francesco, Vairo, Francesco, and Valli, Maria Beatrice

Subjects
0301 basic medicine, Drug, Male, Microbiology (medical), medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), COVID19, media_common.quotation_subject, Critical Illness, 030106 microbiology, Pneumonia, Viral, remdesivir, Loading dose, Gastroenterology, Antiviral Agents, NO, 03 medical and health sciences, Betacoronavirus, Adenosine Triphosphate, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Pandemics, media_common, EC50, Original Research, Aged, Pharmacology, Lung, Alanine, Nucleoside analogue, business.industry, SARS-CoV-2, COVID-19, Recovery of Function, Prodrug, Adenosine Monophosphate, 030104 developmental biology, medicine.anatomical_structure, Infectious Diseases, Pharmacokinetics, COVID19, remdesivir, Female, business, Coronavirus Infections, medicine.drug
Abstract

Background Remdesivir is a prodrug of the nucleoside analogue GS-441524 and is under evaluation for treatment of SARS-CoV-2-infected patients. Objectives To evaluate the pharmacokinetics of remdesivir and GS-441524 in plasma, bronchoalveolar aspirate (BAS) and CSF in two critically ill COVID-19 patients. Methods Remdesivir was administered at 200 mg loading dose on the first day followed by 12 days of 100 mg in two critically ill patients. Blood samples were collected immediately after (C0) and at 1 (C1) and 24 h (C24) after intravenous administration on day 3 until day 9. BAS samples were collected on Days 4, 7 and 9 from both patients while one CSF on Day 7 was obtained in one patient. Remdesivir and GS-441524 concentrations were measured in these samples using a validated UHPLC-MS/MS method. Results We observed higher concentrations of remdesivir at C0 (6- to 7-fold higher than EC50 from in vitro studies) and a notable decay at C1. GS-441524 plasma concentrations reached a peak at C1 and persisted until the next administration. Higher concentrations of GS-441524 were observed in the patient with mild renal dysfunction. Mean BAS/plasma concentration ratios of GS-441524 were 2.3% and 6.4% in Patient 1 and Patient 2, respectively. The CSF concentration found in Patient 2 was 25.7% with respect to plasma. GS-441524 levels in lung and CNS suggest compartmental differences in drug exposure. Conclusions We report the first pharmacokinetic evaluation of remdesivir and GS-441524 in recovered COVID-19 patients. Further study of the pharmacokinetic profile of remdesivir, GS-441524 and the intracellular triphosphate form are required.

Published
2020
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