47 results on '"Lakshminarayana, Suresh B."'
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2. Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors
3. Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections
4. A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
5. Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)
6. Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria
7. Spiroindolones, a Potent Compound Class for the Treatment of Malaria
8. An Adenosine Nucleoside Inhibitor of Dengue Virus
9. Combination of α-glucosidase inhibitor and ribavirin for the treatment of dengue virus infection in vitro and in vivo
10. Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents
11. Practical Anticipation of Human Efficacious Doses and Pharmacokinetics Using In Vitro and Preclinical In Vivo Data
12. NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models
13. Differences in the pharmacokinetics of currently approved antimalarial drugs in uncomplicated malaria patients compared to healthy subjects
14. A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′- C -Methylguanosine for the Treatment of Dengue Virus Infection
15. A Cyclic Phosphoramidate Prodrug of 2’-deoxy-2’-fluoro-2’-C-methylguanosine for the Treatment of Dengue Infection
16. Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure–Activity Relationship Studies, and Biological Assessment
17. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
18. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites
19. Mutations in Genes for the F 420 Biosynthetic Pathway and a Nitroreductase Enzyme Are the Primary Resistance Determinants in Spontaneous In Vitro -Selected PA-824-Resistant Mutants of Mycobacterium tuberculosis
20. Discovery of Dengue Virus NS4B Inhibitors
21. Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model
22. Direct inhibitors of InhA are active against Mycobacterium tuberculosis
23. Comprehensive physicochemical, pharmacokinetic and activity profiling of anti-TB agents
24. Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis
25. Lead Optimization of Imidazopyrazines: A New Class of Antimalarial with Activity on Plasmodium Liver Stages
26. Corrrection to Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Novel Antitubercular Agents
27. Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis
28. Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides: A Promising Class of Antituberculosis Agents
29. Discovery of Tetrahydropyrazolopyrimidine Carboxamide Derivatives As Potent and Orally Active Antitubercular Agents
30. Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents
31. A CryptosporidiumPI(4)K inhibitor is a drug candidate for cryptosporidiosis
32. A Translation Inhibitor That Suppresses Dengue Virus In Vitro and In Vivo
33. Structure–Activity Relationships of Antitubercular Nitroimidazoles. 3. Exploration of the Linker and Lipophilic Tail of ((S)-2-Nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-(4-trifluoromethoxybenzyl)amine (6-Amino PA-824).
34. Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents
35. Inhibition of Dengue Virus by an Ester Prodrug of an Adenosine Analog
36. Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria
37. Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N ′6′-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate
38. Design, Synthesis, and BiologicalEvaluation of Indole-2-carboxamides:A Promising Class of Antituberculosis Agents.
39. Mutations in Genes for the F420Biosynthetic Pathway and a Nitroreductase Enzyme Are the Primary Resistance Determinants in Spontaneous In Vitro-Selected PA-824-Resistant Mutants of Mycobacterium tuberculosis
40. Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model
41. A Translation Inhibitor That Suppresses Dengue Virus In Vitroand In Vivo
42. Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N′6′-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate
43. Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of african trypanosomiasis
44. Discovery of Dengue Virus NS4B Inhibitors.
45. Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria.
46. Mutations in genes for the F420 biosynthetic pathway and a nitroreductase enzyme are the primary resistance determinants in spontaneous in vitro-selected PA-824-resistant mutants of Mycobacterium tuberculosis.
47. Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.
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