1. A single-cell transcriptomic atlas characterizes ageing tissues in the mouse
- Author
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Nicholas Schaum, Ashley Maynard, Kenneth I. Weinberg, Ishita Bansal, Annie Lo, Christin S. Kuo, Hamid Ebadi, Norma Neff, Bryan D. Merrill, Gunsagar S. Gulati, Michelle B. Chen, Nathalie Khoury, Song E. Lee, Martin J. Zhang, Michael N. Wosczyna, Linda J. van Weele, Lakshmi P. Yerra, James Zou, Matt Fish, Michael F. Clarke, Antoine de Morrée, Lucas M. Waldburger, Kyle J. Travaglini, Maria F. Lugo-Fagundo, Yan Hang, Rasika Patkar, Kerwyn Casey Huang, Weng Chuan Peng, Wan Jin Lu, Astrid Gillich, Andrew May, Aaron Demers, Tony Wyss-Coray, Benoit Lehallier, William Kong, Douglas Brownfield, Robert C. Jones, Katharine M. Ng, Ankit S. Baghel, Patricia K. Nguyen, Rafael Gòmez-Sjöberg, Katherine S. Pollard, Ling Liu, Kevin S. Kao, Róbert Pálovics, Taichi Isobe, Chunyu Zhao, Roel Nusse, Eric J. Rulifson, Maya E. Kumar, Bruce Wang, Philip A. Beachy, Tessa Divita, Ross J. Metzger, Cristina M. Tato, Thomas A. Rando, Marina McKay, Hui Zhang, Oliver Hahn, Jinyi Xiang, Jane Antony, Aaron McGeever, Daniel Staehli, Macy E. Zardeneta, Tal Iram, Olivia Leventhal, Qingyun Li, Angela Oliveira Pisco, Lolita Penland, Krissie Tellez, Marco Mignardi, Brian Yu, Shaheen S. Sikandar, Lincoln Harris, Nicole Almanzar, Corey Cain, Geraldine Genetiano, Foad Green, Davis P. Lee, Carolina Tropini, Laughing Bear Torrez Dulgeroff, Rahul Sinha, Zhen Qi, Stephen R. Quake, Charles Chan, Irving L. Weissman, Sean M. Wu, Jim Karkanias, Ahmad N. Nabhan, Andreas Keller, Margaret Tsui, Alexander Zee, Guruswamy Karnam, Michael S. Haney, Haley du Bois, Robert Puccinelli, Ben A. Barres, Justin L. Sonnenburg, F. Hernan Espinoza, Fabio Zanini, Qiang Gan, Joseph Noh, Lu Zhou, Isaac Bakerman, Aaron M. Kershner, Mark A. Krasnow, Kubilay Demir, Feather Ives, Benson M. George, Guang Li, Dullei Min, Justin Youngyunpipatkul, Mu He, Rene V. Sit, Bernhard M. Kiss, Stephanie D. Conley, Seung K. Kim, Weilun Tan, Soso Xue, M. Windy McNerney, Andrew C. Yang, Kevin A. Yamauchi, Albin Huang, Joe M. Segal, Krzysztof Szade, Michelle Tan, Biter Bilen, Fan Zhang, Spyros Darmanis, Shayan Hosseinzadeh, Xueying Gu, Jonathan K. Lam, Anoop Manjunath, and Daniela Berdnik
- Subjects
Male ,Aging ,T-Lymphocytes ,DNA Mutational Analysis ,Cell ,Computational biology ,Biology ,Article ,Genomic Instability ,Transcriptome ,Mice ,medicine ,Animals ,Cellular Senescence ,Multidisciplinary ,Atlas (topology) ,Immunity ,Gene Expression Regulation, Developmental ,medicine.anatomical_structure ,Liver ,Organ Specificity ,Ageing ,Models, Animal ,Female ,Single-Cell Analysis - Abstract
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death(1). Despite rapid advances over recent years, many of the molecular and cellular processes which underlie progressive loss of healthy physiology are poorly understood(2). To gain a better insight into these processes we have created a single cell transcriptomic atlas across the life span of Mus musculus which includes data from 23 tissues and organs. We discovered cell-specific changes occurring across multiple cell types and organs, as well as age related changes in the cellular composition of different organs. Using single-cell transcriptomic data we were able to assess cell type specific manifestations of different hallmarks of aging, such as senescence(3), genomic instability(4) and changes in the organism’s immune system(2). This Tabula Muris Senis provides a wealth of new molecular information about how the most significant hallmarks of aging are reflected in a broad range of tissues and cell types.
- Published
- 2020