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7. Prevalence and Clinical Correlations of Antibodies Against Six β2-Glycoprotein-I-Related Peptides in the Antiphospholipid Syndrome

Author

Shoenfeld, Y., Krause, I., Kvapil, F., Sulkes, J., Lev, S., Von Landenberg, P., Font, J., Zaech, J., Cervera, R., Piette, J. C., Boffa, M. C., Khamashta, M. A., Bertolaccini, M. L., Hughes, G. R. V., Youinou, P., Meroni, P. L., Pengo, V., Alves, J. D., Tincani, A., Szegedi, G., Lakos, G., Sturfelt, G., Jönsen, A., Koike, T., Sanmarco, M., Ruffatti, A., Ulcova-Gallova, Z., Praprotnik, S., Rozman, B., Lorber, M., Vriezman, V. B., and Blank, M.

Published
2003
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17. ANTIPHOSPHOLIPID SYNDROME (APS): PATTERNS OF DISEASE EXPRESSION IN A COHORT OF 1,000 PATIENTS.

Author

Cervera, R, Piette, J C, Font, J, Khamashta, M A, Shoenfeld, Y, Camps, M T, Jacobsen, S, Lakos, G, Tincani, A, Kontopoulo-Griva, I, Galeazzi, M, Meroni, P L, Derksen, R HWM, de Groot, F G, Gromnica-Ihle, E, Baleva, M, Bombardieri, S, Houssiau, F, Gris, J C, Quere, I, Hachulla, E, Vasconcelos, C, Roch, B, Fernandez-Nebro, A, Boffa, M, Hughes, G RV C, and Ingelmo, M

Published
2001

26. International multi-center evaluation of a novel chemiluminescence assay for the detection of anti-dsDNA antibodies

Author

Bentow, C., Lakos, G., Martis, P., Wahl, E., Garcia, M., Vinas, O., Espinosa, G., Cervera, R., Sjöwall, Christopher, Carmona-Fernandes, D., Santos, M. J., Hanly, J. G., Mahler, M., Bentow, C., Lakos, G., Martis, P., Wahl, E., Garcia, M., Vinas, O., Espinosa, G., Cervera, R., Sjöwall, Christopher, Carmona-Fernandes, D., Santos, M. J., Hanly, J. G., and Mahler, M.

Abstract

Objective: Anti-double stranded desoxyribonucleic acid (anti-dsDNA) antibodies are considered fairly specific for systemic lupus erythematosus (SLE) and their quantification is useful for the clinical management of SLE patients. We assessed the diagnostic performance of the QUANTA Flash dsDNA chemiluminescent immunoassay (CIA) in comparison to an ELISA, using patients from five participating countries. The main focus was to evaluate the correlation between anti-dsDNA antibody results from the CIA and global SLE disease activity, as measured by the SLE Disease Activity Index 2000 (SLEDAI-2K). Patients and methods: A total of 1431 samples (SLE, n=843; disease controls, n=588) from five countries (Canada, USA, Portugal, Sweden and Spain) were tested with QUANTA Flash dsDNA (Inova Diagnostics, San Diego, CA, USA). Data obtained with the QUANTA Lite dsDNA SC ELISA (Inova Diagnostics) were available for samples from three sites (Canada, USA and Sweden, n=566). The SLEDAI-2K scores were available for 805 SLE patients and a cut-off ofamp;gt;4 was used to define active disease. Results: QUANTA Flash dsDNA had a sensitivity of 54.3% for the diagnosis of SLE, combined with 89.8% specificity. Anti-dsDNA antibody levels were significantly higher (pamp;lt;0.0001) in active SLE (SLEDAI-2Kamp;gt;4; n=232; median value 83.0IU/mL) versus the inactive patients (n=573; median value 22.3IU/mL), and the SLEDAI-2K scoring correlated with their dsDNA antibody levels (Spearmans rho=0.44, pamp;lt;0.0001). Similar but less pronounced findings were also found for the ELISA, in relation to disease activity. Conclusions: The QUANTA Flash dsDNA assay showed good clinical performance in a large international multi-center study. Additionally, the strong correlation between anti-dsDNA antibody results and SLEDAI-2K scores supported the potential utility of QUANTA Flash dsDNA for monitoring disease activity.

Published
2016
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32. Features associated with epilepsy in the antiphospholipid syndrome

Author

Shoenfeld, Y, Lev, S, Blatt, I, Blank, M, Font, J, von Landenberg, P, Lev, N, Zaech, J, Cervera, R, Piette, Jc, Bertolaccini, Ml, Hughes, Gr, Youinou, P, Meroni, Pl, Pengo, V, Alves, Jd, Tincani, Angela, Szegedi, G, Lakos, G, Sturfelt, G, Jonsen, A, Koike, T, Sanmarco, M, Ruffatti, A, Ulcova Gallova, Z, Praprotnik, S, Rozman, B, Lorber, M, Chapman, J, van Breda Vriezman PJ, and Damoiseaux, J.

Published
2004

33. Features associated with epilepsy in the antiphospholipid syndrome

Author

Shoenfeld, Y., Lev, S., Blatt, I., Font, J., VON LANDENBERG, P., Lev, N., Zaech, J., Cervera, R., Piette, J. C., Bertolaccini, M. L., Hughes, G. R., Youinou, P., Meroni, P. L., Pengo, Vittorio, Alves, J. D., Tincani, A., Szegedi, G., Lakos, G., Sturfelt, G., Jonsen, A., Koike, T., Sanmarco, M., Ruffatti, Amelia, ULCOVA GALLOVA, Z., Praprotnik, S., Rozman, B., Lorber, M., Chapman, J., VAN BREDA VRIEZMAN, P. J., and Damoiseaux, J.

Published
2004

34. Prevalence and clinical correlations of antibodies against six beta2-glycoprotein-I-related peptides in the antiphospholipid syndrome

Author

Shoenfeld, Y., Krause, I., Kvapil, F., Sulkes, J., Lev, S., Landenberg, P., Font, J., Zaech, J., Cervera, R., Piette, J. C., Boffa, M. C., Khamashta, M. A., Maria Laura Bertolaccini, Hughes, G. R. V., Youinou, P., Meroni, P. L., Pengo, V., Alves, J. D., Tincani, A., Szegedi, G., Lakos, G., Sturfelt, G., Jönsen, A., Koike, T., Sanmarco, M., Ruffatti, A., Ulcova-Gallova, Z., Praprotnik, S., Rozman, B., Lorber, M., Vriezman, V. B., and Blank, M.

Subjects
Adult, Adolescent, beta 2-Glycoprotein I, Molecular Sequence Data, Humans, Lupus Erythematosus, Systemic, Amino Acid Sequence, Middle Aged, Antiphospholipid Syndrome, Peptides, Antibodies, Glycoproteins
Abstract

Two-hundred ninety five patients with the antiphospholipid syndrome (APS) were studied for the presence of antibodies against six anti-beta2GPI-related peptides Abs. The prevalence of a wide spectrum of clinical and laboratory parameters of APS was evaluated in all patients, and correlated with the presence of each anti-beta2GPI peptide antibody. The rates of the various antipeptides Abs ranged from 18.0 to 63.7%. Altogether, 87.1% of the patients had antibody reactivity against at least one of the six beta2GPI-related peptides. A high degree of simultaneous reactivity against several beta2GPI-peptides was found. Positive and negative correlations were found between several antipeptides Abs and the rates of thrombosis and fetal loss. Our results point to a heterogeneous activity of antiphospholipid Abs in APS patients, directed, often concurrently, against various epitopes of the beta2GPI molecule. Evaluation of APS patients for the presence of specific antipeptides Abs may be of a value in predicting the risk for future thrombotic and obstetrical complication, as well as for specific therapeutic purposes.

Published
2003

35. Prevalence and clinical correlations of antibodies against six beta2-Glycoprotein-I related peptides in the antiphospholipid syndrome

Author

Shoenfeld, Y, Krause, I, Kvapil, F, Sulkes, J, Lev, S, VON LANDENBERG, P, Font, J, Zaech, J, Cervera, R, Piette, Jc, Boffa, Mc, Khamashta, Ma, Bertolaccini, Ml, Hughes, Gr, Youinou, P, Meroni, Pl, Pengo, Vittorio, Alves, Jd, Tincani, A, Szegedi, G, Lakos, G, Sturfelt, G, Jonsen, A, Koike, T, Sanmarco, M, Ruffatti, Amelia, ULCOVA GALLOVA, Z, Praprotnik, S, Rozman, B, Lorber, M, Vriezman, Vb, and Blank, M.

Published
2003

36. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients

Author

Cervera, R, Piette, Jc, Font, J, Khamashta, Ma, Shoenfeld, Y, Camps, Mt, Jacobsen, S, Lakos, G, Tincani, Angela, Kontopoulou Griva, I, Galeazzi, M, Meroni, Pl, Derksen, Rh, de Groot PG, Gromnica Ihle, E, Baleva, M, Mosca, M, Bombardieri, S, Houssiau, F, Gris, Jc, Quere, I, Hachulla, E, Vasconcelos, C, Roch, B, Fernandez Nebro, A, Boffa, Mc, Hughes, Gr, and Ingelmo, M.

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Lupus Vasculitis, Central Nervous System, Infant, Newborn, Infant, Middle Aged, Antiphospholipid Syndrome, Cohort Studies, Diagnosis, Differential, Age Distribution, Child, Preschool, Prevalence, Humans, Female, Sex Distribution, Child, Aged, Autoantibodies
Abstract

To analyze the clinical and immunologic manifestations of antiphospholipid syndrome (APS) in a large cohort of patients and to define patterns of disease expression.The clinical and serologic features of APS (Sapporo preliminary criteria) in 1,000 patients from 13 European countries were analyzed using a computerized database.The cohort consisted of 820 female patients (82.0%) and 180 male patients (18.0%) with a mean +/- SD age of 42 +/- 14 years at study entry. "Primary" APS was present in 53.1% of the patients; APS was associated with systemic lupus erythematosus (SLE) in 36.2%, with lupus-like syndrome in 5.0%, and with other diseases in 5.9%. A variety of thrombotic manifestations affecting the majority of organs were recorded. A catastrophic APS occurred in 0.8% of the patients. Patients with APS associated with SLE had more episodes of arthritis and livedo reticularis, and more frequently exhibited thrombocytopenia and leukopenia. Female patients had a higher frequency of arthritis, livedo reticularis, and migraine. Male patients had a higher frequency of myocardial infarction, epilepsy, and arterial thrombosis in the lower legs and feet. In 28 patients (2.8%), disease onset occurred before age 15; these patients had more episodes of chorea and jugular vein thrombosis than the remaining patients. In 127 patients (12.7%), disease onset occurred after age 50; most of these patients were men. These patients had a higher frequency of stroke and angina pectoris, but a lower frequency of livedo reticularis, than the remaining patients.APS may affect any organ of the body and display a broad spectrum of manifestations. An association with SLE, the patient's sex, and the patient's age at disease onset can modify the disease expression and define specific subsets of APS.

Published
2002

37. Membranous glomerulonephritis in a patient with inherited activated protein C resistance

Author

Regéczy N, Lakos G, Istvan Balogh, Kappelmayer J, and Kiss E

Subjects
Adult, Risk Factors, Humans, Thrombophilia, Female, Antiphospholipid Syndrome, Glomerulonephritis, Membranous, Activated Protein C Resistance
Abstract

We present a patient with membranous glomerulonephritis, several clinical complications of the antiphospholipid syndrome and ulcerative colitis, but without lupus anticoagulant and antiphospholipid/cofactor antibodies. Immunological studies--other antibodies--were negative and failed to show enough criteria for any autoimmune diseases. Evaluation of her laboratory tests for hereditary thrombophilia revealed a heterozygous form of the Leiden mutation that might be associated with widespread vasculopathy. An interesting possibility is that the inherited activated protein C resistance could be an additional risk factor for vaso-occlusive manifestations appearing as a clinical sign of cardiovascular diseases and nephropathy.

Published
2001

42. ‘Criteria’ aPL tests: Report of a Task Force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas, April 2010

Author

Pierangeli, SS, primary, Groot, PG de, additional, Dlott, J, additional, Favaloro, E, additional, Harris, EN, additional, Lakos, G, additional, Ortel, T, additional, Meroni, PL, additional, Otomo, K, additional, Pengo, V, additional, Tincani, A, additional, Wong, R, additional, and Roubey, R, additional

Published
2011
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44. P285 COMPARING CONVENTIONAL AND GASCA TESTS FOR THE DIAGNOSIS AND DETERMINATION OF CLINICAL PHENOTYPE IN CROHN'S DISEASE

Author

Lakatos, P.L., primary, Altorjay, I., additional, Dotan, N., additional, Tumpek, J., additional, Sipka, S., additional, Lakos, G., additional, Palatka, K., additional, Lakatos, L., additional, Kovacs, A., additional, Molnar, T., additional, Tulassay, Z., additional, Miheller, P., additional, Norman, G.L., additional, Szamosi, T., additional, and Maria, P., additional

Published
2008
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49. P002 SERO-REACTIVITY TO MICROBIAL COMPONENTS IN CROHN'S DISEASE IS ASSOCIATED WITH ILEAL INVOLVEMENT, NON-INFLAMMATORY DISEASE BEHAVIOUR AND NOD2/CARD15 GENOTYPE, BUT NOT RESPONSE TO MEDICAL THERAPY OR RISK FOR SURGERY

Author

Papp, M., primary, Altorjay, I., additional, Norman, G.L., additional, Palatka, K., additional, Lakos, G., additional, Fischer, S., additional, Lakatos, L., additional, Bene, L., additional, Molnar, T., additional, Tulassay, Z., additional, Miheller, P., additional, and LakatosL, P., additional

Published
2007
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