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139 results on '"Lainez, Nuria"'

1. Prospective Assessment of Bone Metabolism Biomarkers and Survival in Metastatic Castration-resistant Prostate Cancer Patients Treated with Radium-223: The PRORADIUM Study

Author

Romero-Laorden, Nuria, Lorente, David, de Velasco, Guillermo, Lozano, Rebeca, Herrera, Bernardo, Puente, Javier, López, Pedro P., Medina, Ana, Almagro, Elena, Gonzalez-Billalabeitia, Enrique, Villla-Guzman, Jose Carlos, González-del-Alba, Aránzazu, Borrega, Pablo, Laínez, Nuria, Fernández-Freire, Ana, Hernández, Amaia, Rodriguez-Vida, Alejo, Chirivella, Isabel, Fernandez-Parra, Eva, López-Campos, Fernando, Isabel Pacheco, Maria, Morales-Barrera, Rafael, Fernández, Ovidio, Villatoro, Rosa, Luque, Raquel, Hernando, Susana, Castellano, Daniel C., Castro, Elena, and Olmos, David

Published
2024
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2. Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03

Author

Garcia-Donas, Jesus, Hurtado, Alicia, Garrigos, Laia, Santaballa, Ana, Redondo, Andres, Vidal, Laura, Lainez, Nuria, Guerra, Eva, Rodriguez, Victor, Cueva, Juan, Bover, Isabel, Palacio, Isabel, Rubio, Maria Jesus, Prieto, Mario, Lopez-Guerrero, Jose Antonio, Rodriguez-Moreno, Juan Francisco, Garcia-Casado, Zaida, Garcia-Martinez, Elena, Taus, Alvaro, de Castro, Ignacio Pérez, Navarro, Paloma, and Grande, Enrique

Published
2023
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3. Real-world data (RWD) with avelumab in patients (pts) with locally advanced or metastatic urothelial cancer (la-mUC): The AVEBLADDER study.

Author

Sotelo, Marta, primary, Pelaez, Mireia, additional, Basterretxea, Laura, additional, Varga, Estrella, additional, Sánchez-Escribano, Ricardo, additional, Pujol, Eduardo, additional, Santander, Carmen, additional, Martinez-Kareaga, Mireia, additional, Arruti Ibarbia, Mikel, additional, Rodríguez Ledesma, Inma, additional, Álvarez-Fernández, Carlos, additional, Piedra, Pablo, additional, Calderero, Veronica, additional, Lainez, Nuria, additional, Verdun Aguilar, Juan Antonio, additional, Gil-Arnaiz, Irene, additional, Fernandez, Ricardo, additional, Mazas, Cristina, additional, and Duran, Ignacio, additional

Published
2024
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5. Clinical Factors Associated With Long-Term Benefit in Patients With Metastatic Renal Cell Carcinoma Treated With Axitinib: Real-World AXILONG Study

Author

Pinto, Álvaro, Reig, Oscar, Iglesias, Clara, Gallardo, Enrique, García-del Muro, Xavier, Alonso, Teresa, Anguera, Georgia, Suárez, Cristina, Muñoz-Langa, José, Villalobos-León, Laura, Rodríguez-Sánchez, Ángel, Lainez, Nuria, Martínez-Ortega, Esther, Campayo, Marc, Velastegui, Alejandro, Rodriguez-Vida, Alejo, Villa-Guzmán, José C., Méndez-Vidal, Maria J., Rubio, Gustavo, García, Iciar, Capdevila, Laia, Lambea, Julio, Vázquez, Sergio, Fernández, Ovidio, Hernando-Polo, Susana, Cerezo, Sara, Santander, Carmen, García-Marrero, Rosa, Zambrana, Francisco, González-del Alba, Aranzazu, Lazaro-Quintela, Martin, Castellano, Daniel, Chirivella, Isabel, Anido, Urbano, Viana, Antonio, García, Arancha, Sotelo, Miguel, Arévalo, María Garrido, García-Donas, Jesús, Hernández, Carolina, Bolós, M. Victoria, Llinares, Julia, and Climent, Miguel A.

Published
2022
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7. Supplementary Figure S1 from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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8. Supplementary Table S2 from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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9. Data from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
Full Text
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10. Supplementary Appendix S1 from Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Author

Leman, Raphaël, primary, Muller, Etienne, primary, Legros, Angelina, primary, Goardon, Nicolas, primary, Chentli, Imène, primary, Atkinson, Alexandre, primary, Tranchant, Aurore, primary, Castera, Laurent, primary, Krieger, Sophie, primary, Ricou, Agathe, primary, Boulouard, Flavie, primary, Joly, Florence, primary, Boucly, Romain, primary, Dumont, Aurélie, primary, Basset, Noémie, primary, Coulet, Florence, primary, Chevalier, Louise-Marie, primary, Rouleau, Etienne, primary, Leitner, Katharina, primary, González-Martin, Antonio, primary, Gargiulo, Piera, primary, Lück, Hans-Joachim, primary, Genestie, Catherine, primary, Bogner, Gerhard, primary, Marth, Christian, primary, Petru, Edgar, primary, Reinthaller, Alexander, primary, Schauer, Christian, primary, Sevelda, Paul, primary, D'Hondt, Lionel, primary, Vergote, Ignace, primary, Vuylsteke, Peter, primary, Hietanen, Sakari, primary, Lindahl, Gabriel, primary, Mäenpää, Johanna, primary, Nøttrup, Trine Jakobi, primary, Puistola, Ulla, primary, Abadie-Lacourtoisie, Sophie, primary, Alexandre, Jérôme, primary, Boissier, Emilie, primary, Bourgeois, Hugues, primary, Chevalier-Place, Annick, primary, Combe, Pierre, primary, Costan, Cristina, primary, Dauba, Jérôme, primary, De Cock, Laure, primary, Desauw, Christophe, primary, Despax, Raymond, primary, Dohollou, Nadine, primary, Dubot, Coraline, primary, Fabbro, Michel, primary, Favier, Laure, primary, Floquet, Anne, primary, Follana, Philippe, primary, Tixidre, Claire Garnier, primary, Garnier, Georges, primary, Gladieff, Laurence, primary, Grenier, Julien, primary, Guillemet, Cécile, primary, Hardy-Bessard, Anne-Claire, primary, Kalbacher, Elsa, primary, Kaminsky, Marie-Christine, primary, Kurtz, Jean-Emmanuel, primary, Largillier, Rémy, primary, Lefeuvre-Plesse, Claudia, primary, Lesoin, Anne, primary, Levache, Charles-Briac, primary, L'Haridon, Tifenn, primary, Lortholary, Alain, primary, Lotz, Jean-Pierre, primary, Meunier, Jérôme, primary, Mousseau, Mirerille, primary, Mouret-Reynier, Marie-Ange, primary, Pautier, Patricia, primary, Petit, Thierry, primary, Provansal, Magali, primary, Pujade-Lauraine, Eric, primary, Raban, Nadia, primary, Ray-Coquard, Isabelle, primary, Rodrigues, Manuel, primary, Selle, Frédéric, primary, Sverdlin, Robert, primary, Tazi, Youssef, primary, You, Benoît, primary, Aktas, Bahriye, primary, Bauerschlag, Dirk Olaf, primary, Beck, Thomas, primary, Belau, Antje, primary, Bronger, Holger, primary, Buchholz, Stefan, primary, Buderath, Paul, primary, Burges, Alexander, primary, Canzler, Ulrich, primary, de Gregorio, Nikolaus, primary, Denschlag, Dominik, primary, Dieterich, Max, primary, Eichbaum, Michael, primary, El-Balat, Ahmed, primary, Emons, Günter, primary, Fasching, Peter, primary, Feisel-Schwickardi, Gabriele, primary, Frank, Matthias, primary, Friedrich, Michael, primary, Grischke, Eva-Maria, primary, Gropp-Meier, Martina, primary, Hanker, Lars, primary, Hannig, Carla, primary, Harter, Philipp, primary, Hasenburg, Annette, primary, Hellriegel, Martin, primary, Herwig, Uwe, primary, Heubner, Martin, primary, Hulde, Joachim, primary, Jackisch, Christian, primary, Kögel, Matthias, primary, Krieger, Peter, primary, Kühn, Thorsten, primary, Liebrich, Clemens, primary, Mallmann, Peter, primary, Marmé, Frederik, primary, Meier, Werner, primary, Möbus, Voker, primary, Mohamed, Omar Farag, primary, Nestle-Krämling, Carolin, primary, Neunhöffer, Tanja, primary, Oskay-Özcelik, Gülten, primary, Park-Simon, Tjoung-Won, primary, Rautenberg, Beate, primary, Rein, Daniel, primary, Ruhwedel, Wencke, primary, Runnebaum, Ingo, primary, Sagasser, Jacqueline, primary, Schmalfeldt, Barbara, primary, Schneeweiss, Andreas, primary, Schnelzer, Andreas, primary, Scholz, Heinz, primary, Sehouli, Jalid, primary, Sperfeld, Antje, primary, Steckkönig, Annette, primary, Strauß, Hans-Georg, primary, Tomé, Oliver, primary, Treustedt, Jörn, primary, Voß, Hermann, primary, Wischnik, Arthur, primary, Witteler, Ralf, primary, Wöckel, Achim, primary, Woeltjen, Hans-Heinrich, primary, Zorr, Andreas, primary, Bologna, Alessandra, primary, Colombo, Nicoletta, primary, Tognon, Germana, primary, Cinieri, Saverio, primary, Lorusso, Domenica, primary, Mosconi, Anna Maria, primary, Pignata, Sandro, primary, Savarese, Antonella, primary, Scambia, Giovanni, primary, Sorio, Roberto, primary, Zamagni, Claudio, primary, Fujiwara, Keiichi, primary, Fujiwara, Hiroyuki, primary, Kobayashi, Hiroaki, primary, Matsumoto, Takashi, primary, Nagao, Shoji, primary, Satoh, Toyomi, primary, Yonemori, Kan, primary, Yoshida, Hiroyuki, primary, Bratos, Raquel, primary, Caballero, Cristina, primary, Garica, Yolanda, primary, González-Martín, Antonio, primary, Alia, Eva Maria Guerra, primary, Hernando, Susana, primary, Herrero, Ana, primary, Lainez, Nuria, primary, Manso, Luis, primary, Martin, Cristina, primary, Murata, Eleonor, primary, Ortega, Eugenia, primary, Palacio, Isabel, primary, Poveda, Andres, primary, Romero, Ignacio, primary, Rubio, Maria Jesús, primary, and Vaur, Dominique, primary

Published
2023
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13. #66 Survival of PARP inhibitor (PARPi) naïve ovarian cancer patients with a BRCA-mutation receiving maintenance olaparib after chemotherapy for first recurrence. An exploratory analysis of the solo2/engot-ov21 trial

Author

Ledermann, Jonathan A, primary, Ray-Coquard, Isabelle, additional, Penson, Richard, additional, Lee, Chee, additional, Oza, Amit, additional, Korach, Jacob, additional, Lainez, Nuria, additional, Scambia, Giovanni, additional, Gebski, Val, additional, Colombo, Nicoletta, additional, Welz, Julia, additional, Fujiwara, Keiichi, additional, Lowe, Elizabeth S, additional, and Pujade-Lauraine, Eric, additional

Published
2023
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14. Results of the FLAC European Database of Metastatic Castration-Resistant Prostate Cancer Patients Treated With Docetaxel, Cabazitaxel, and Androgen Receptor–Targeted Agents

Author

Angelergues, Antoine, Efstathiou, Eleni, Gyftaki, Revekka, Wysocki, Piotr Jan, Lainez, Nuria, Gonzalez, Iria, Castellano, Daniel E., Ozguroglu, Mustafa, Carbonero, Iciar Garcia, Flechon, Aude, Borrega, Pablo, Guillot, Aline, Balea, Begona Campos, Le Moulec, Sylvestre, Esteban, Emilio, Munarriz, Javier, Rubio, Gustavo, Birtle, Alison J., Delanoy, Nicolas, Bellmunt, Joaquim, and Oudard, Stéphane

Published
2018
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15. Recent advances in genitourinary tumors: A review focused on biology and systemic treatment

Author

González del Alba, Aránzazu, Arranz, José Ángel, Puente, Javier, Méndez-Vidal, María José, Gallardo, Enrique, Grande, Enrique, Pérez-Valderrama, Begoña, González-Billalabeitia, Enrique, Lázaro-Quintela, Martín, Pinto, Álvaro, Lainez, Nuria, Piulats, Josep M., Esteban, Emilio, Maroto Rey, José Pablo, García, Jorge A., and Suárez, Cristina

Published
2017
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16. Maintenance therapy with vinflunine plus best supportive care versus best supportive care alone in patients with advanced urothelial carcinoma with a response after first-line chemotherapy (MAJA; SOGUG 2011/02): a multicentre, randomised, controlled, open-label, phase 2 trial

Author

García-Donas, Jesus, Font, Albert, Pérez-Valderrama, Begoña, Virizuela, José Antonio, Climent, Miquel Ángel, Hernando-Polo, Susana, Arranz, José Ángel, del Mar Llorente, Maria, Lainez, Nuria, Villa-Guzmán, José Carlos, Mellado, Begoña, del Alba, Aránzazu González, Castellano, Daniel, Gallardo, Enrique, Anido, Urbano, del Muro, Xavier García, Domènech, Montserrat, Puente, Javier, Morales-Barrera, Rafael, Pérez-Gracia, Jose Luis, and Bellmunt, Joaquim

Published
2017
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17. Time without symptoms or toxicity (TWiST) in patients with newly diagnosed advanced ovarian cancer receiving maintenance olaparib or placebo plus bevacizumab: Analysis of PAOLA-1/ENGOT-ov25 phase III trial.

Author

Joly, Florence, primary, Chabaud, Sylvie, additional, Cropet, Claire, additional, Anota, Amélie, additional, Demarchi, Martin, additional, Atasevan, Beyhan, additional, Pisano, Carmen, additional, Lainez, Nuria, additional, Tsibulak, Irina, additional, Yonemori, Kan, additional, Vergote, Ignace, additional, Lapresa, Maria, additional, Mirza, Mansoor Raza, additional, Guillemet, Cecile, additional, Burges, Alexander, additional, Scambia, Giovanni, additional, Ortega Izquierdo, Eugenia, additional, Pujade-Lauraine, Eric, additional, Kurtz, Jean Emmanuel, additional, and Ray-Coquard, Isabelle Laure, additional

Published
2022
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18. Role of Surgery in Patients with Recurrent, Metastatic, or Unresectable Locally Advanced Gastrointestinal Stromal Tumors Sensitive to Imatinib: A Retrospective Analysis of the Spanish Group for Research on Sarcoma (GEIS)

Author

Rubió-Casadevall, Jordi, Martinez-Trufero, Javier, Garcia-Albeniz, Xabier, Calabuig, Silvia, Lopez-Pousa, Antonio, del Muro, Javier Garcia, Fra, Joaquin, Redondo, Andrés, Lainez, Nuria, Poveda, Andrés, Valverde, Claudia, De Juan, Ana, Sevilla, Isabel, Casado, Antonio, Andres, Raquel, Cruz, Josefina, Martin-Broto, Javier, Maurel, Joan, and the Spanish Group for Research on Sarcoma (GEIS)

Published
2015
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19. Comprehensive molecular characterization of muscle-invasive bladder cancer (MIBC) treated with durvalumab plus olaparib in the neoadjuvant setting: Neodurvarib trial.

Author

Rodriguez-Moreno, Juan Francisco, primary, Ruiz-Llorente, Sergio, additional, De Velasco, Guillermo, additional, Alvarez-Fernandez, Carlos, additional, Collado Martín, Ricardo, additional, Fernandez, Ricardo, additional, Vazquez-Estevez, Sergio, additional, Virizuela, Juan Antonio, additional, Gajate, Pablo, additional, Font, Albert, additional, Lainez, Nuria, additional, Barquin, Arantzazu, additional, Beltran, Luis, additional, Rodriguez-Antona, Cristina, additional, Berraondo, Pedro, additional, and García-Donas, Jesús, additional

Published
2022
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20. Epithelial-to-Mesenchymal Transition Mediates Resistance to Maintenance Therapy with Vinflunine in Advanced Urothelial Cell Carcinoma

Author

Font, Albert, primary, Ruiz de Porras, Vicenç, additional, Valderrama, Begoña P., additional, Ramirez, Jose Luis, additional, Nonell, Lara, additional, Virizuela, José Antonio, additional, Anido, Urbano, additional, González-del-Alba, Aránzazu, additional, Lainez, Nuria, additional, Llorente, Maria del Mar, additional, Jiménez, Natalia, additional, Mellado, Begoña, additional, García-Donas, Jesus, additional, and Bellmunt, Joaquim, additional

Published
2021
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25. Supplementary_data – Supplemental material for Expert recommendations on the management of patients with metastatic castration-resistant prostate cancer who progress after CHAARTED or LATITUDE

Author

Puente, Javier, Anido, Urbano, Climent, Miguel Ángel, Gonzalez-Billalabeitia, Enrique, Lainez, Nuria, Lambea, Julio, Maroto, José Pablo, Mendez-Vidal, Maria Jose, Montesa, Álvaro, Rodriguez, Angel, Curro Zambrana, and González-Del-Alba, Aránzazu

Subjects
110203 Respiratory Diseases, FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, Supplementary_data for Expert recommendations on the management of patients with metastatic castration-resistant prostate cancer who progress after CHAARTED or LATITUDE by Javier Puente, Urbano Anido, Miguel Ángel Climent, Enrique Gonzalez-Billalabeitia, Nuria Lainez, Julio Lambea, José Pablo Maroto, Maria Jose Mendez-Vidal, Álvaro Montesa, Angel Rodriguez, Curro Zambrana and Aránzazu González-del-Alba in Therapeutic Advances in Medical Oncology

Published
2020
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26. Association Between Second Progression-free Survival (PFS2) and Overall Survival in Metastatic Castration-resistant Prostate Cancer

Author

Lorente, David, primary, Castro, Elena, additional, Lozano, Rebeca, additional, Puente, Javier, additional, Romero-Laorden, Nuria, additional, Rodríguez-Vida, Alejo, additional, Lainez, Nuria, additional, Villatoro, Rosa, additional, Llácer, Casilda, additional, Cattrini, Carlo, additional, Hernández, Amaia, additional, Domenech, Montserrat, additional, Zambrana, Francisco, additional, Almagro, Elena, additional, Luque, Raquel, additional, Martinez, Esther, additional, López-Campos, Fernando, additional, Gonzalez, Belen, additional, Méndez-Vidal, Maria Jose, additional, Medina, Ana, additional, Piulats, Josep Maria, additional, and Olmos, David, additional

Published
2020
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27. Cabazitaxel versus enzalutamide/abiraterone in CARD eligible mCRPC patients with or without germline HRR defects.

Author

Romero-Laorden, Nuria, primary, Lozano, Rebeca, additional, Llacer Perez, Casilda, additional, Piulats Rodriguez, Jose Maria M., additional, Puente, Javier, additional, Lorente, David, additional, Medina, Ana, additional, Cattrini, Carlo, additional, Vitrone, Francesca, additional, Almagro, Elena, additional, Borrega, Pablo, additional, Lainez, Nuria, additional, Rivera, Leticia, additional, Villatoro, Rosa, additional, Hernandez, Amaia, additional, Rodriguez-Vida, Alejo, additional, López-Casas, Pedro P., additional, Gallardo Diaz, Enrique, additional, Castro, Elena, additional, and Olmos, David, additional

Published
2020
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28. Retrospective study to identify clinical factors related to a high benefit of axitinib in mRCC: Results from AXILONG Spanish real-world study.

Author

Pinto, Alvaro, primary, Iglesias Gomez, Clara, additional, Climent, Miguel Ángel, additional, Gallardo Diaz, Enrique, additional, Garcia del Muro, Xavier, additional, Alonso Gordoa, Teresa, additional, Llinares Legido, Julia Inmaculada, additional, Suarez Rodriguez, Cristina, additional, Anguera, Georgia, additional, Muñoz-Langa, José, additional, Lainez, Nuria, additional, Rodriguez Sanchez, Angel, additional, Martínez Ortega, Esther, additional, Villalobos, Maria L., additional, and Reig Torras, Oscar, additional

Published
2020
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29. Atezolizumab (atezo) therapy for upper tract (UT) urothelial carcinoma (UC): Subgroup analysis of the single-arm international SAUL study in pretreated locally advanced/metastatic urinary tract carcinoma.

Author

Sternberg, Cora N., primary, Loriot, Yohann, additional, Tambaro, Rosa, additional, Buttigliero, Consuelo, additional, Morelli, Franco, additional, Papai, Zsuzsanna, additional, Retz, Margitta, additional, Necchi, Andrea, additional, Van Der Heijden, Michiel Simon, additional, Faust, Guy, additional, Cardona Zorrilla, Andres Felipe, additional, Lainez, Nuria, additional, Panni, Stefano, additional, Etxaniz, Olatz, additional, Krieger, Laurence, additional, Mendez Vidal, Maria Jose José, additional, Los, Maartje, additional, de Ducla, Sabine, additional, Fear, Simon, additional, and Merseburger, Axel Stuart, additional

Published
2020
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30. Expert recommendations on the management of patients with metastatic castration-resistant prostate cancer who progress after CHAARTED or LATITUDE

Author

Puente, Javier, primary, Anido, Urbano, additional, Climent, Miguel Ángel, additional, Gonzalez-Billalabeitia, Enrique, additional, Lainez, Nuria, additional, Lambea, Julio, additional, Maroto, José Pablo, additional, Mendez-Vidal, Maria Jose, additional, Montesa, Álvaro, additional, Rodriguez, Angel, additional, Zambrana, Curro, additional, and González-del-Alba, Aránzazu, additional

Published
2020
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31. Treatment sequence in elderly metastatic castration-resistant prostate cancer (mCRPC) patients (pts) in a prospective cohort study.

Author

Mendez-Vidal, Maria Jose, primary, Lozano, Rebeca, additional, Castro, Elena, additional, Romero-Laorden, Nuria, additional, Rodriguez-Vida, Alejo, additional, Lainez, Nuria, additional, Hernandez, Amaia, additional, Villatoro, Rosa, additional, Zambrana, Francisco, additional, Guzman, Jose Carlos Villa, additional, García Domínguez, Rocío, additional, Galvan Ruiz, Saray, additional, Escribano, Ricardo, additional, Gallardo Díaz, Enrique, additional, Querol, Rosa, additional, Luque, Raquel, additional, Gonzalez del Alba, Aránzazu, additional, Puente, Javier, additional, Olmos, David, additional, and Lorente, David, additional

Published
2019
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32. Identification of prognostic variables in advanced ovarian cancer based on real-world patients from big data analytics.

Author

García-Donas, Jesús, primary, Sevillano, Elena, additional, Muñoz, Sergio, additional, Bote, Luis, additional, Yagüe, Monica, additional, Lainez, Nuria, additional, Guerra, Eva Mª, additional, Garrido, Maria, additional, Garcia-Donas, Teresa, additional, Amarilla, Sandra, additional, Navarro, Paloma, additional, Ruiz, Sergio, additional, Fenor, MD, additional, Rodriguez-Moreno, Juan Francisco, additional, and Rojo, Jose Luis, additional

Published
2019
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33. Correlation between time to PSA progression (TTPP), radiographic progression-free survival (rPFS) and overall survival (OS) in first-line abiraterone/enzalutamide (Abi/Enza) and docetaxel (Doc) treated patients in a prospective cohort study.

Author

Lorente, David, primary, Castro, Elena, additional, Lozano, Rebeca, additional, Puente, Javier, additional, Romero-Laorden, Nuria, additional, Morales-Barrera, Rafael, additional, Rodriguez Vida, Alejo, additional, Sáez, M Isabel, additional, Mendez-Vidal, Maria Jose, additional, Fernandez, Eva, additional, Almagro, Elena, additional, Hernandez, Amaia, additional, Hernando Polo, Susana, additional, Pérez-Valderrama, Begoña, additional, López-Campos, Fernando, additional, Llacer Perez, Casilda, additional, Montesa, A., additional, Lainez, Nuria, additional, Piulats, Josep M., additional, and Olmos, David, additional

Published
2019
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34. Open Label Phase III Clinical Trial of Ketoconazole as CYP17 Inhibitor in Metastatic or Advanced Non-Resectable Granulosa Cell Ovarian Tumors. The GREKO (GRanulosa Et KetOconazole) Trial. GETHI 2011-03

Author

Garcia-Donas, Jesus, primary, Hurtado, Alicia, additional, Garrigos, Laia, additional, Santaballa, Ana, additional, Redondo, Andres, additional, Vidal, Laura, additional, Lainez, Nuria, additional, Guerra, Eva, additional, Rodriguez, Victor, additional, Cueva, Juan, additional, Bover, Isabel, additional, Palacio, Isabel, additional, Rubio, Maria Jesus, additional, Prieto, Mario, additional, Lopez-Guerrero, Jose Antonio, additional, Rodriguez-Moreno, Juan Francisco, additional, Garcia-Casado, Zaida, additional, Garcia-Martinez, Elena, additional, Taus, Alvaro, additional, Pérez de Castro, Ignacio, additional, Navarro, Paloma, additional, Hernando, Susana, additional, and Grande, Enrique, additional

Published
2019
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35. PTEN expression and mutations in TSC1, TSC2 and MTOR are associated with response to rapalogs in patients with renal cell carcinoma.

Author

Roldan‐Romero, Juan M., Beuselinck, Benoit, Santos, María, Rodriguez‐Moreno, Juan F., Lanillos, Javier, Calsina, Bruna, Gutierrez, Ana, Tang, Karin, Lainez, Nuria, Puente, Javier, Castellano, Daniel, Esteban, Emilio, Climent, Miguel A., Arranz, Jose A., Albersen, Maarten, Oudard, Stephane, Couchy, Gabrielle, Caleiras, Eduardo, Montero‐Conde, Cristina, and Cascón, Alberto

Subjects
RENAL cell carcinoma, NUCLEOTIDE sequencing
Abstract

The mammalian target of rapamycin (mTOR) pathway inhibitors are key drugs for the treatment of many tumor types, however, there are no predictive biomarkers in clinical use. Here, we performed a molecular and immunohistochemical characterization of key mTOR pathway components in a series of 105 renal cell carcinoma patients treated with rapalogs, aimed at identifying markers of treatment response. Mutational analysis in MTOR, TSC1 and TSC2 was performed through targeted next‐generation sequencing (NGS), and immunohistochemistry (IHC) was performed for PTEN, pAKT, pS6K1, pS6 and p21. Among patients with NGS data, 11 of 87 (13%) had mTOR pathway mutations (8 in MTOR, 1 in TSC1 and 2 in TSC2). When comparing the molecular data to the response of the patients, we found that partial response was more frequent in cases with mTOR pathway mutations than in those without mutations (odds ratio [OR] = 0.08, 95% confidence interval [CI] = 0.008–0.79, p = 0.030 univariate; p = 0.038 multivariable). Regarding IHC, negative PTEN staining was detected in 58% of the tumors, and it was more frequent in rapalog responder patients (OR = 0.24, 95% CI = 0.065–0.86, p = 0.029 univariate; p = 0.029 multivariable). Mutations and PTEN IHC were not mutually exclusive events and its combination improved response prediction (OR = 0.16, 95% CI = 0.04–0.62, p = 0.008 univariate; p = 0.013 multivariable). The staining of other proteins did not show and association with response and no association with PFS was observed in unselected patients. In conclusion, our findings suggest that mTOR pathway mutations, negative PTEN IHC and their combination are potential markers of rapalog response. What's new? Inhibitors of the mammalian Target of Rapamycin (mTOR) are key drugs for the treatment of renal cell carcinoma. However, only a subset of patients benefits clinically, and it is unclear why. Here the authors identified mutations in mTOR pathway, as well as loss of expression of the tumor suppressor PTEN, as markers of favorable outcome, underscoring the potential of these markers– either alone or in combination – to serve as clinical tools for patient stratification. [ABSTRACT FROM AUTHOR]

Published
2020
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36. Gene expression analyses determine two different subpopulations in KIT-negative GIST-like (KNGL) patients

Author

Moura, David S., primary, Ramos, Rafael, additional, Fernandez-Serra, Antonio, additional, Serrano, Teresa, additional, Cruz, Julia, additional, Alvarez-Alegret, Ramiro, additional, Ortiz-Duran, Rosa, additional, Vicioso, Luis, additional, Gomez-Dorronsoro, Maria Luisa, additional, Garcia del Muro, Xavier, additional, Martinez-Trufero, Javier, additional, Rubio-Casadevall, Jordi, additional, Sevilla, Isabel, additional, Lainez, Nuria, additional, Gutierrez, Antonio, additional, Serrano, Cesar, additional, Lopez-Alvarez, Maria, additional, Hindi, Nadia, additional, Taron, Miguel, additional, López-Guerrero, José Antonio, additional, and Martin-Broto, Javier, additional

Published
2018
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37. Outcomes of metastatic castration resistant prostate cancer (mCRPC) patients with DNA repair germline mutations (gDDR) following first taxane-based treatment.

Author

Puente, Javier, primary, Romero-Laorden, Nuria, additional, Vallespin Garcia, Elena, additional, Piulats, Josep M., additional, Saez, M Isabel, additional, Fernandez Parra, Eva, additional, Perez Valderrama, Begona, additional, Borrega, Pablo, additional, Cendon, Ylenia, additional, Ibáñez, Kristina, additional, Lainez, Nuria, additional, Heras, Lucia, additional, Velez, Edelmira, additional, Almagro, Elena, additional, Zambrana, Francisco, additional, García Domínguez, Rocío, additional, Contreras, Jose Antonio, additional, Lapunzina, Pablo, additional, Olmos, David, additional, and Castro, Elena, additional

Published
2018
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38. Novel potential predictive markers of sunitinib outcomes in long-term responders versus primary refractory patients with metastatic clear-cell renal cell carcinoma

Author

Puente, Javier, Lainez, Nuria, Dueñas, Marta, Méndez-Vidal, María José, Esteban, Emilio, Castellano, Daniel, Martínez-Fernández, Mónica, Basterretxea, Laura, Juan-Fita, María José, Antón-Aparicio, Luis M., León, Luis, Lambea, Julio, Pérez-Valderrama, Begoña, Vázquez, Sergio, Suárez, Cristina, García del Muro, Xavier, Gallardo, Enrique, Maroto, José Pablo, Samaniego, M. Luz, Suárez-Paniagua, Beatriz, Sanz, Julián, Paramio, Jesús M., Puente, Javier, Lainez, Nuria, Dueñas, Marta, Méndez-Vidal, María José, Esteban, Emilio, Castellano, Daniel, Martínez-Fernández, Mónica, Basterretxea, Laura, Juan-Fita, María José, Antón-Aparicio, Luis M., León, Luis, Lambea, Julio, Pérez-Valderrama, Begoña, Vázquez, Sergio, Suárez, Cristina, García del Muro, Xavier, Gallardo, Enrique, Maroto, José Pablo, Samaniego, M. Luz, Suárez-Paniagua, Beatriz, Sanz, Julián, and Paramio, Jesús M.

Abstract

[Abstract] Background: Several potential predictive markers of efficacy of targeted agents in patients with metastatic renal cell carcinoma (mRCC) have been identified. Interindividual heterogeneity warrants further investigation. Patients and methods: Multicenter, observational, retrospective study in patients with clear-cell mRCC treated with sunitinib. Patients were classified in two groups: long-term responders (LR) (progression-free survival (PFS)≥22 months and at least stable disease), and primary refractory (PR) (progressive disease within 3-months of sunitinib onset). Objectives were to compare baseline clinical factors in both populations and to correlate tumor expression of selected signaling pathways components with sunitinib PFS. Results: 123 patients were analyzed (97 LR, 26 PR). In the LR cohort, overall response rate was 79% and median duration of best response was 30 months. Median PFS and overall survival were 43.2 (95% confidence intervals[CI]:37.2-49.3) and 63.5 months (95%CI:55.1-71.9), respectively. At baseline PR patients had a significantly lower proportion of nephrectomies, higher lactate dehydrogenase and platelets levels, lower hemoglobin, shorter time to and higher presence of metastases, and increased Fuhrman grade. Higher levels of HEYL, HEY and HES1 were observed in LR, although only HEYL discriminated populations significantly (AUC[ROC]=0.704; cut-off=34.85). Increased levels of hsa-miR-27b, hsa-miR-23b and hsa-miR-628-5p were also associated with prolonged survival. No statistical significant associations between hsa-miR-23b or hsa-miR-27b and the expression of c-Met were found. Conclusions: Certain mRCC patients treated with sunitinib achieve extremely long-term responses. Favorable baseline hematology values and longer time to metastasis may predict longer PFS. HEYL, hsa-miR-27b, hsa-miR-23b and hsa-miR-628-5p could be potentially used as biomarkers of sunitinib response.

Published
2017

40. Sequencing in metastatic castration-resistant prostate cancer (mCRPC): Updated results of the FLAC International Database.

Author

Delanoy, Nicolas, primary, Angelergues, Antoine, additional, Efstathiou, Eleni, additional, Gyftaki, Revekka, additional, Wysocki, Piotr Jan, additional, Lainez, Nuria, additional, Gonzalez, Iria, additional, Castellano, Daniel E., additional, Ozguroglu, Mustafa, additional, Garcia Carbonero, Iciar, additional, Flechon, Aude, additional, Borrega, Pablo, additional, Guillot, Aline, additional, Campos Balea, Begona, additional, Le Moulec, Sylvestre, additional, Esteban, Emilio, additional, Munarriz, Javier, additional, Barker, Claire, additional, Birtle, Alison J., additional, and Oudard, Stephane, additional

Published
2017
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41. Predictors for survival with cabazitaxel (CBZ) in metastatic, castration-resistant prostate cancer (mCRPC): Long term follow-up of the Spanish registry.

Author

González-Maeso, Iria, primary, Lainez, Nuria, additional, Castellano, Daniel, additional, Garcia Carbonero, Iciar, additional, Borrega, Pablo, additional, Campos Balea, Begona, additional, Garcia Marrero, Rosa, additional, Esteban, Emilio, additional, Rodriguez Vida, Alejo, additional, Munarriz, Javier, additional, Garcia-Bueno, Jose Maria, additional, Villalobos, Maria L., additional, Viciana, Ruth, additional, Rubio, Gustavo, additional, Perez-Valderrama, Begoña, additional, Garcia Sanchez, Jose, additional, Pelaez Lorenzo, Beatriz, additional, Cumplido Buron, Jose David, additional, Martin, Almudena, additional, and Bellmunt, Joaquim, additional

Published
2017
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42. Functional PTGS2 polymorphism-based models as novel predictive markers in metastatic renal cell carcinoma patients receiving first-line sunitinib

Author

Cebrián, Arancha, primary, Gómez del Pulgar, Teresa, additional, Méndez-Vidal, María José, additional, Gonzálvez, María Luisa, additional, Lainez, Nuria, additional, Castellano, Daniel, additional, García-Carbonero, Iciar, additional, Esteban, Emilio, additional, Sáez, Maria Isabel, additional, Villatoro, Rosa, additional, Suárez, Cristina, additional, Carrato, Alfredo, additional, Munárriz-Ferrándiz, Javier, additional, Basterrechea, Laura, additional, García-Alonso, Mirta, additional, González-Larriba, José Luis, additional, Perez-Valderrama, Begoña, additional, Cruz-Jurado, Josefina, additional, González del Alba, Aránzazu, additional, Moreno, Fernando, additional, Reynés, Gaspar, additional, Rodríguez-Remírez, María, additional, Boni, Valentina, additional, Mahillo-Fernández, Ignacio, additional, Martin, Yolanda, additional, Viqueira, Andrea, additional, and García-Foncillas, Jesús, additional

Published
2017
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43. Phosphorylated-insulin growth factor I receptor (p-IGF1R) and metalloproteinase-3 (MMP3) expression in advanced gastrointestinal stromal tumors (GIST). A GEIS 19 study

Author

Maurel, Joan, primary, López-Pousa, Antonio, additional, Calabuig, Silvia, additional, Bagué, Silvia, additional, del Muro, Xavier Garcia, additional, Sanjuan, Xavier, additional, Rubió-Casadevall, Jordi, additional, Cuatrecasas, Miriam, additional, Martinez-Trufero, Javier, additional, Horndler, Carlos, additional, Fra, Joaquin, additional, Valverde, Claudia, additional, Redondo, Andrés, additional, Poveda, Andrés, additional, Sevilla, Isabel, additional, Lainez, Nuria, additional, Rubini, Michele, additional, García-Albéniz, Xabier, additional, Martín-Broto, Javier, additional, and de Alava, Enrique, additional

Published
2016
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44. Integrated analysis of mRNA and miRNA to unravel novel mechanisms of sunitinib long term response in mRCC.

Author

Puente, Javier, primary, Lainez, Nuria, additional, Dueñas, Marta, additional, Méndez-Vidal, María José, additional, Esteban, Emilio, additional, Castellano, Daniel E., additional, Basterrechea, Laura, additional, Juan Fita, María José, additional, Antón Aparicio, L. M., additional, Anido, Urbano, additional, Lambea- Sorrosal, Julio Jose, additional, Perez-Valderrama, Begoña, additional, Vazquez-Estevez, Sergio, additional, Suárez, Cristina, additional, Garcia del Muro, Xavier, additional, Diaz, Enrique Gallardo, additional, Maroto, Pablo, additional, Samaniego, Luz, additional, Suárez, Beatriz, additional, and Paramio, Jesus, additional

Published
2016
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45. SNPs associated with activity and toxicity of cabazitaxel in patients with advanced urothelial cell carcinoma

Author

Duran, Ignacio, primary, Hagen, Carlos, additional, Arranz, José Ángel, additional, Apellaniz-Ruiz, María, additional, Pérez-Valderrama, Begoña, additional, Sala, Nuria, additional, Lainez, Nuria, additional, García-Del Muro, Xavier, additional, Noguerón, Esther, additional, Climent, Miguel Ángel, additional, Maroto, Pablo, additional, Font, Albert, additional, García-Donas, Jesús, additional, Gallardo, Enrique, additional, López-Criado, Pilar, additional, González Del Alba, Aránzazu, additional, Sáez, María Isabel, additional, Vázquez, Sergio, additional, Luque, Raquel, additional, and Rodríguez-Antona, Cristina, additional

Published
2016
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46. Impact on clinical practice of the implementation of guidelines for the toxicity management of targeted therapies in kidney cancer. The protect-2 study

Author

Lainez, Nuria, primary, García-Donas, Jesús, additional, Esteban, Emilio, additional, Puente, Javier, additional, Sáez, M. Isabel, additional, Gallardo, Enrique, additional, Pinto-Marín, Álvaro, additional, Vázquez-Estévez, Sergio, additional, León, Luis, additional, García-Carbonero, Icíar, additional, Suárez-Rodríguez, Cristina, additional, Molins, Carmen, additional, Climent-Duran, Miguel A., additional, Lázaro-Quintela, Martín, additional, González del Alba, Aranzazu, additional, Méndez-Vidal, María José, additional, Chirivella, Isabel, additional, Afonso, Francisco J., additional, López-Brea, Marta, additional, Sala-González, Nuria, additional, Domenech, Montserrat, additional, Basterretxea, Laura, additional, Santander-Lobera, Carmen, additional, Gil-Arnáiz, Irene, additional, Fernández, Ovidio, additional, Caballero-Díaz, Cristina, additional, Mellado, Begoña, additional, Marrupe, David, additional, García-Sánchez, José, additional, Sánchez-Escribano, Ricardo, additional, Fernández Parra, Eva, additional, Villa Guzmán, José C., additional, Martínez-Ortega, Esther, additional, Belén González, María, additional, Morán, Marina, additional, Suarez-Paniagua, Beatriz, additional, Lecumberri, María J., additional, and Castellano, Daniel, additional

Published
2016
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49. Vinflunine maintenance therapy versus best supportive care after platinum combination in advanced bladder cancer: A phase II, randomized, open label, study (MAJA study, SOGUG 2011-02)—Interim analysis on safety.

Author

Polo, Susana Hernando, primary, Gonzalez del Alba, Aranzazu, additional, Perez-Valderrama, Begoña, additional, Villa Guzman, José Carlos, additional, Climent, Miguel Angel, additional, Lainez, Nuria, additional, Font, Albert, additional, Duran, Ignacio, additional, Mellado, Begoña, additional, Castellano, Daniel, additional, García-Donas, Jesús, additional, Virizuela, Juan Antonio, additional, Leon, Luis, additional, LLorente, Maria del Mar, additional, Domenech, Montserrat, additional, Morales, Rafael, additional, Gallardo, Enrique, additional, Puente, Javier, additional, Maciá, Sonia, additional, and Bellmunt, Joaquim, additional

Published
2014
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