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9. Optimization of Sample Preparation for Pesticide Analysis in Oil-Based Cannabis Products Using LipiFiltr[R]

Author

Kinsella, Brian, Bhattarai, Bikash, Kowalski, Julie, Laine, Derek, Minier, Sara, Soule, Aimee, and Bode, Gwen

Subjects
Chemistry
Abstract

This application note outlines the performance benefits achieved with UCT's LipiFiltr cleanup cartridge for the analysis of pesticides in oil-based cannabis products using LC-MS/MS analysis. The pesticides evaluated in this [...]

Published
2018

14. Enhanced Reactivity of Superoxide in Water--Solid Matrices.

Author

FURMAN, OLHA, LAINE, DEREK F., BLUMENFELD, ALEXANDER, TEEL, AMY L., SHIMIZU, KENICHI, CHENG, I. FRANCIS, and WATTS, RICHARD J.

Subjects
*SURFACE chemistry, *REACTIVITY (Chemistry), *SUPEROXIDES, *ALIPHATIC compounds, *HYDROGEN peroxide, *HEXACHLOROETHANE, *ELECTRON paramagnetic resonance spectroscopy, *FENTON'S reagent, *CHEMISTRY experiments
Abstract

Superoxide is unreactive in deionized water, but aqueous systems containing added solvents, including H2O2 at >100 mM, show significantly increased reactivity of superoxide with oxidized organic compounds such as highly chlorinated aliphatics. The potential for solid surfaces to similarly increase the reactivity of superoxide in water was investigated. Heterogeneous birnessite (γ-MnO2)-catalyzed decomposition of H2O2 promoted the degradation of the superoxide probe hexachloroethane (HCA) at H2O2 concentrations as low as 7.5 mM, while no measurable HCA degradation was found in parallel homogeneous iron(III)-EDTA-H2O2 systems at H2O2 concentrations <100 mM. Electron spin resonance spectroscopy confirmed that superoxide was the dominant reactive species generated in the birnessite-catalyzed decomposition of H2O2. Increased superoxide reactivity was also found in aqueous superoxide-glass bead heterogeneous systems, and the rates of HCA degradation increased as a function of the surface area of the glass beads. The results of this research show that, similar to the addition of solvents, the presence of surfaces also enhances the reactivity of superoxide in water, possibly by altering the superoxide solvation shell. On the basis of these findings, superoxide generated in catalyzed H2O2 propagations (CHP; modified Fenton's reagent) used for in situ chemical oxidation (ISCO) may have greater reactivity with highly oxidized contaminants than previously thought. [ABSTRACT FROM AUTHOR]

Published
2009
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15. Evaluation of Modified QuEChERS for Pesticide Analysis in Cannabis.

Author

Kowalski, Julie, Dahl, Jeffrey H., Rigdon, Amanda, Cochran, Jack, Laine, Derek, and Fagras, Gordon

Subjects
PESTICIDE analysis, SOLID phase extraction, ELECTROSPRAY ionization mass spectrometry, MASS spectrometry, FORTIFICATION
Abstract

Although systems for growing, production, and sale of cannabis and cannabis related products are well established, regulation and enforcement of quality and safety testing have lagged behind. However, state governments and private laboratories are focusing on product safety testing with special emphasis on pesticide analysis. This focus is partially the result of various product recalls, media attention, and concern from patient advocacy groups. We evaluated a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation method followed by liquid chromatography–tandem mass spectrometry (LC–MS/MS) for the analysis of multiresidue pesticides. The Association of Analytical Communities International (AOAC) QuEChERS method was used for a reduced 1.5-g amount of plant material and processed with a universal dispersive solid-phase extraction (dSPE) formulation. LC–MS/MS analysis used constant polarity switching electrospray ionization (ESI) and monitored at least two transitions per analyte. Matrix-matched calibration was used for quantitation and both method and instrument internal standards were used. Analyte recovery validation was performed according to the United States Food and Drug Administration (US FDA) guidelines by testing three matrices at three fortification levels in triplicate for more than 200 pesticides. For the large majority of pesticides, in all three matrices and at all three fortification levels, recovery was 70-120%. [ABSTRACT FROM AUTHOR]

Published
2017

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