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2. Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study

Author

Chan, Chang-Chuan, Chan, Si-Wa, Chang, I-Shou, Chang, Jer-Hwa, Chao, Kun-San, Chen, Chi-Jen, Chen, Huei-Wen, Chiang, Chun-Ju, Chiou, Hung-Yi, Chou, Mei-Chun, Chung, Chi-Li, Chung, Ta-Jung, Guo, Yue Leon, Hsiao, Chin-Fu, Huang, Chien-Sheng, Ko, Sheung-Fat, Lee, Mei-Hsuan, Li, Yao-Jen, Liao, Yu-San, Lu, Yueh-Hsun, Ou, Hsin-You, Wu, Ping-An, Yang, Hwai-I, Yang, Shi-Yi, Yang, Szu-Chun, Chang, Gee-Chen, Chiu, Chao-Hua, Yu, Chong-Jen, Chang, Yeun-Chung, Chang, Ya-Hsuan, Hsu, Kuo-Hsuan, Wu, Yu-Chung, Chen, Chih-Yi, Hsu, Hsian-He, Wu, Ming-Ting, Yang, Cheng-Ta, Chong, Inn-Wen, Lin, Yu-Ching, Hsia, Te-Chun, Lin, Meng-Chih, Su, Wu-Chou, Lin, Chih-Bin, Lee, Kang-Yun, Wei, Yu-Feng, Lan, Gong-Yau, Chan, Wing P, Wang, Kao-Lun, Wu, Mei-Han, Tsai, Hao-Hung, Chian, Chih-Feng, Lai, Ruay-Sheng, Shih, Jin-Yuan, Wang, Chi-Liang, Hsu, Jui-Sheng, Chen, Kun-Chieh, Chen, Chun-Ku, Hsia, Jiun-Yi, Peng, Chung-Kan, Tang, En-Kuei, Hsu, Chia-Lin, Chou, Teh-Ying, Shen, Wei-Chih, Tsai, Ying-Huang, Tsai, Chun-Ming, Chen, Yuh-Min, Lee, Yu-Chin, Chen, Hsuan-Yu, Yu, Sung-Liang, Chen, Chien-Jen, Wan, Yung-Liang, Hsiung, Chao Agnes, and Yang, Pan-Chyr

Published
2024
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3. Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study

Author

Chang, Gee-Chen, primary, Chiu, Chao-Hua, additional, Yu, Chong-Jen, additional, Chang, Yeun-Chung, additional, Chang, Ya-Hsuan, additional, Hsu, Kuo-Hsuan, additional, Wu, Yu-Chung, additional, Chen, Chih-Yi, additional, Hsu, Hsian-He, additional, Wu, Ming-Ting, additional, Yang, Cheng-Ta, additional, Chong, Inn-Wen, additional, Lin, Yu-Ching, additional, Hsia, Te-Chun, additional, Lin, Meng-Chih, additional, Su, Wu-Chou, additional, Lin, Chih-Bin, additional, Lee, Kang-Yun, additional, Wei, Yu-Feng, additional, Lan, Gong-Yau, additional, Chan, Wing P, additional, Wang, Kao-Lun, additional, Wu, Mei-Han, additional, Tsai, Hao-Hung, additional, Chian, Chih-Feng, additional, Lai, Ruay-Sheng, additional, Shih, Jin-Yuan, additional, Wang, Chi-Liang, additional, Hsu, Jui-Sheng, additional, Chen, Kun-Chieh, additional, Chen, Chun-Ku, additional, Hsia, Jiun-Yi, additional, Peng, Chung-Kan, additional, Tang, En-Kuei, additional, Hsu, Chia-Lin, additional, Chou, Teh-Ying, additional, Shen, Wei-Chih, additional, Tsai, Ying-Huang, additional, Tsai, Chun-Ming, additional, Chen, Yuh-Min, additional, Lee, Yu-Chin, additional, Chen, Hsuan-Yu, additional, Yu, Sung-Liang, additional, Chen, Chien-Jen, additional, Wan, Yung-Liang, additional, Hsiung, Chao Agnes, additional, Yang, Pan-Chyr, additional, Chan, Chang-Chuan, additional, Chan, Si-Wa, additional, Chang, I-Shou, additional, Chang, Jer-Hwa, additional, Chao, Kun-San, additional, Chen, Chi-Jen, additional, Chen, Huei-Wen, additional, Chiang, Chun-Ju, additional, Chiou, Hung-Yi, additional, Chou, Mei-Chun, additional, Chung, Chi-Li, additional, Chung, Ta-Jung, additional, Guo, Yue Leon, additional, Hsiao, Chin-Fu, additional, Huang, Chien-Sheng, additional, Ko, Sheung-Fat, additional, Lee, Mei-Hsuan, additional, Li, Yao-Jen, additional, Liao, Yu-San, additional, Lu, Yueh-Hsun, additional, Ou, Hsin-You, additional, Wu, Ping-An, additional, Yang, Hwai-I, additional, Yang, Shi-Yi, additional, and Yang, Szu-Chun, additional

Published
2023
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7. Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study

Author

Chang, Gee-Chen, Chiu, Chao-Hua, Yu, Chong-Jen, Chang, Yeun-Chung, Chang, Ya-Hsuan, Hsu, Kuo-Hsuan, Wu, Yu-Chung, Chen, Chih-Yi, Hsu, Hsian-He, Wu, Ming-Ting, Yang, Cheng-Ta, Chong, Inn-Wen, Lin, Yu-Ching, Hsia, Te-Chun, Lin, Meng-Chih, Su, Wu-Chou, Lin, Chih-Bin, Lee, Kang-Yun, Wei, Yu-Feng, Lan, Gong-Yau, Chan, Wing P, Wang, Kao-Lun, Wu, Mei-Han, Tsai, Hao-Hung, Chian, Chih-Feng, Lai, Ruay-Sheng, Shih, Jin-Yuan, Wang, Chi-Liang, Hsu, Jui-Sheng, Chen, Kun-Chieh, Chen, Chun-Ku, Hsia, Jiun-Yi, Peng, Chung-Kan, Tang, En-Kuei, Hsu, Chia-Lin, Chou, Teh-Ying, Shen, Wei-Chih, Tsai, Ying-Huang, Tsai, Chun-Ming, Chen, Yuh-Min, Lee, Yu-Chin, Chen, Hsuan-Yu, Yu, Sung-Liang, Chen, Chien-Jen, Wan, Yung-Liang, Hsiung, Chao Agnes, Yang, Pan-Chyr, Chan, Chang-Chuan, Chan, Si-Wa, Chang, I-Shou, Chang, Jer-Hwa, Chao, Kun-San, Chen, Chi-Jen, Chen, Huei-Wen, Chiang, Chun-Ju, Chiou, Hung-Yi, Chou, Mei-Chun, Chung, Chi-Li, Chung, Ta-Jung, Guo, Yue Leon, Hsiao, Chin-Fu, Huang, Chien-Sheng, Ko, Sheung-Fat, Lee, Mei-Hsuan, Li, Yao-Jen, Liao, Yu-San, Lu, Yueh-Hsun, Ou, Hsin-You, Wu, Ping-An, Yang, Hwai-I, Yang, Shi-Yi, and Yang, Szu-Chun

Abstract

In Taiwan, lung cancers occur predominantly in never-smokers, of whom nearly 60% have stage IV disease at diagnosis. We aimed to assess the efficacy of low-dose CT (LDCT) screening among never-smokers, who had other risk factors for lung cancer.

Published
2024
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9. BTEX exposure and its body burden pose differential risks for asthma and its phenotypic clusters

Author

Hsu, Yuan‐Ting, primary, Wu, Chao‐Chien, additional, Wang, Chin‐Chou, additional, Chung, Wen‐Yu, additional, Sheu, Chau‐Chyun, additional, Yang, Yi‐Hsin, additional, Cheng, Ming‐Yen, additional, Lai, Ruay‐Sheng, additional, Leung, Sum‐Yee, additional, Lin, Chi‐Cheng, additional, Wei, Yu‐Feng, additional, Lin, Ching‐Hsiung, additional, Lin, Sheng‐Hao, additional, Hsu, Jeng‐Yuan, additional, Huang, Wei‐Chang, additional, Tseng, Chia‐Cheng, additional, Lai, Yung‐Fa, additional, Cheng, Meng‐Hsuan, additional, Chen, Huang‐Chi, additional, Yang, Chih‐Jen, additional, Su, Chian‐Heng, additional, Wang, Chien‐Jen, additional, Hsu, Shih‐Chang, additional, Hung, Chih‐Hsing, additional, Lee, Chon‐Lin, additional, Huang, Ming‐Shyan, additional, and Huang, Shau‐Ku, additional

Published
2023
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10. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment Response in Advanced Lung Adenocarcinomas with G719X/L861Q/S768I Mutations

Author

Chiu, Chao-Hua, Yang, Cheng-Ta, Shih, Jin-Yuan, Huang, Ming-Shyan, Su, Wu-Chou, Lai, Ruay-Sheng, Wang, Chin-Chou, Hsiao, Shih-Hsin, Lin, Yu-Ching, Ho, Ching-Liang, Hsia, Te-Chun, Wu, Ming-Fang, Lai, Chun-Liang, Lee, Kang-Yun, Lin, Chih-Bin, Yu-Wung Yeh, Diana, Chuang, Chi-Yuan, Chang, Fu-Kang, Tsai, Chun-Ming, Perng, Reury-Perng, and Chih-Hsin Yang, James

Published
2015
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12. Environmental risks and sphingolipid signatures in adult asthma and its phenotypic clusters: a multicentre study

Author

Wu, Chao-Chien, primary, Wang, Chin-Chou, additional, Chung, Wen-Yu, additional, Sheu, Chau-Chyun, additional, Yang, Yi-Hsin, additional, Cheng, Ming-Yen, additional, Lai, Ruay-Sheng, additional, Leung, Sum-Yee, additional, Lin, Chi-Cheng, additional, Wei, Yu-Feng, additional, Lin, Ching-Hsiung, additional, Lin, Sheng-Hao, additional, Hsu, Jeng-Yuan, additional, Huang, Wei-Chang, additional, Tseng, Chia-Cheng, additional, Lai, Yung-Fa, additional, Cheng, Meng-Hsuan, additional, Chen, Huang-Chi, additional, Yang, Chih-Jen, additional, Hsu, Shih-Chang, additional, Su, Chian-Heng, additional, Wang, Chien-Jen, additional, Liu, Huei-Ju, additional, Chen, Hua-Ling, additional, Hsu, Yuan-Ting, additional, Hung, Chih-Hsing, additional, Lee, Chon-Lin, additional, Huang, Ming-Shyan, additional, and Huang, Shau-Ku, additional

Published
2022
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13. High efficacy of erlotinib in Taiwanese NSCLC patients in an expanded access program study previously treated with chemotherapy

Author

Perng, Reury-Perng, Yang, Chih-Hsin, Chen, Yuh-Min, Chang, Gee-Chen, Lin, Meng-Chih, Hsieh, Ruey-Kuen, Chu, Nei-Min, Lai, Ruay-Sheng, Su, Wu-Chou, Tsao, Chao-Jung, Hsia, Te-Chun, Chen, Hao-Cheng, Chen, Chih-Hung, Huang, Ming-Shyan, Wang, Jui-Long, Ho, Ming-Lin, Chung, Chih-Yuan, Yu, Chong-Jen, Chang, Wen-Cheng, Kuo, Han-Pin, Yu, Chih-Teng, Lin, Zhong-Zhe, and Kao, Woei-Yau

Published
2008
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14. Environmental risks and sphingolipid signatures in adult asthma and its phenotypic clusters: a multicentre study

Author

Wu, Chao-Chien, Wang, Chin-Chou, Chung, Wen-Yu, Sheu, Chau-Chyun, Yang, Yi-Hsin, Cheng, Ming-Yen, Lai, Ruay-Sheng, Leung, Sum-Yee, Lin, Chi-Cheng, Wei, Yu-Feng, Lin, Ching-Hsiung, Lin, Sheng-Hao, Hsu, Jeng-Yuan, Huang, Wei-Chang, Tseng, Chia-Cheng, Lai, Yung-Fa, Cheng, Meng-Hsuan, Chen, Huang-Chi, Yang, Chih-Jen, Hsu, Shih-Chang, Su, Chian-Heng, Wang, Chien-Jen, Liu, Huei-Ju, Chen, Hua-Ling, Hsu, Yuan-Ting, Hung, Chih-Hsing, Lee, Chon-Lin, Huang, Ming-Shyan, and Huang, Shau-Ku

Abstract

BackgroundAdult asthma is phenotypically heterogeneous with unclear aetiology. We aimed to evaluate the potential contribution of environmental exposure and its ensuing response to asthma and its heterogeneity.MethodsEnvironmental risk was evaluated by assessing the records of National Health Insurance Research Database (NHIRD) and residence-based air pollution (particulate matter with diameter less than 2.5 micrometers (PM2.5) and PM2.5-bound polycyclic aromatic hydrocarbons (PAHs)), integrating biomonitoring analysis of environmental pollutants, inflammatory markers and sphingolipid metabolites in case–control populations with mass spectrometry and ELISA. Phenotypic clustering was evaluated by t-distributed stochastic neighbor embedding (t-SNE) integrating 18 clinical and demographic variables.FindingsIn the NHIRD dataset, modest increase in the relative risk with time-lag effect for emergency (N=209 837) and outpatient visits (N=638 538) was observed with increasing levels of PM2.5and PAHs. Biomonitoring analysis revealed a panel of metals and organic pollutants, particularly metal Ni and PAH, posing a significant risk for current asthma (ORs=1.28–3.48) and its severity, correlating with the level of oxidative stress markers, notably Nε-(hexanoyl)-lysine (r=0.108–0.311, p<0.05), but not with the accumulated levels of PM2.5exposure. Further, levels of circulating sphingosine-1-phosphate and ceramide-1-phosphate were found to discriminate asthma (p<0.001 and p<0.05, respectively), correlating with the levels of PAH (r=0.196, p<0.01) and metal exposure (r=0.202–0.323, p<0.05), respectively, and both correlating with circulating inflammatory markers (r=0.186–0.427, p<0.01). Analysis of six phenotypic clusters and those cases with comorbid type 2 diabetes mellitus (T2DM) revealed cluster-selective environmental risks and biosignatures.InterpretationThese results suggest the potential contribution of environmental factors from multiple sources, their ensuing oxidative stress and sphingolipid remodeling to adult asthma and its phenotypic heterogeneity.

Published
2023
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15. Environmental Risks and Sphingolipid Signatures in Adult Asthma and Its Phenotypic Clusters: A Multi-Center Exploratory Study

Author

Wu, Chao-Chien, primary, Wang, Chin-Chou, additional, Chung, Wen-Yu, additional, Sheu, Chau-Chyun, additional, Yang, Yi-Hsin, additional, Cheng, Ming-Yen, additional, Lai, Ruay-Sheng, additional, Leung, Sum-Yee, additional, Lin, Chi-Cheng, additional, Wei, Yu-Feng, additional, Lin, Ching-Hsiung, additional, Lin, Sheng-Hao, additional, Hsu, Jeng-Yuan, additional, Huang, Wei-Chang, additional, Zheng, Jia-Cheng, additional, Lai, Yung-Fa, additional, Cheng, Meng-Hsuan, additional, Chen, Huang-Chi, additional, Yang, Zhi-Ren, additional, Hsu, Shih-Chang, additional, Su, Chian-Heng, additional, Wang, Chien-Jen, additional, Liu, Huei-Ju, additional, Chen, Hua-Ling, additional, Hsu, Yuan-Ting, additional, Hung, Chih-Hsing, additional, Lee, Chon-Lin, additional, Huang, Ming-Shyan, additional, Huang, Shau-Ku, additional, and Study, The Consortium for Taiwan Asthma, additional

Published
2021
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22. Ambiguous presentation of Mycobacterium avium complex‐associated Rasmussen aneurysm

Author

Chiu, Hsin‐Wei, Kuo, Shu‐Hung, Lai, Ruay‐Sheng, Wu, Ming‐Ting, and Wu, Hsiu‐Fu

Subjects
Rasmussen aneurysm, respiratory infections (non‐tuberculous), Case Report, Case Reports, Angiographic embolization, glue, computed tomography angiography
Abstract

A 77‐year‐old man with a progressively dry cough (two months duration) was admitted with hemoptysis. Chest computed tomography (CT) revealed left lingular lobe consolidation and one thick‐walled cavity lesion over the left lower lobe, which was accompanied by satellite micro‐nodules in a tree‐in‐bud pattern. CT‐guided biopsy confirmed mycobacterial infection, and subsequent culture yielded Mycobacterium avium complex (MAC). Unremitting hemoptysis was present despite treatment (14 days) with ethambutol, rifampin, clarithromycin, and streptomycin. Initial CT angiography (CTA) to determine the source of the hemoptysis revealed a suspected aneurysm in the consolidated left lingular lobe; however, this could not be localized via catheter angiography during the pulmonary and bronchial arterial phases. Two weeks later, a massive hemoptysis episode led to haemodynamic instability and serious consequences. Follow‐up CTA confirmed the previously detected aneurysm, and glue embolization was performed successfully. This case report highlights a rare but catastrophic MAC‐associated pseudoaneurysm and relevant treatment options.

Published
2017

25. A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor

Author

Wong, Tzu-Hsuan, primary, Lee, Chon-Lin, additional, Su, Hsiang-Han, additional, Lee, Chin-Lai, additional, Wu, Chao-Chien, additional, Wang, Chin-Chou, additional, Sheu, Chau-Chyun, additional, Lai, Ruay-Sheng, additional, Leung, Sum-Yee, additional, Lin, Chi-Cheng, additional, Wei, Yu-Feng, additional, Wang, Chien-Jen, additional, Lin, Yu-Chun, additional, Chen, Hua-Ling, additional, Huang, Ming-Shyan, additional, Yen, Jeng-Hsien, additional, Huang, Shau-Ku, additional, and Suen, Jau-Ling, additional

Published
2018
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26. Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma

Author

Hung, Chih-Hsing, primary, Wang, Chin-Chou, additional, Suen, Jau-Ling, additional, Sheu, Chau-Chyun, additional, Kuo, Chang-Hung, additional, Liao, Wei-Ting, additional, Yang, Yi-Hsin, additional, Wu, Chao-Chien, additional, Leung, Sum-Yee, additional, Lai, Ruay-Sheng, additional, Lin, Chi-Cheng, additional, Wei, Yu-Feng, additional, Lee, Chong-Yeh, additional, Huang, Ming-Shyan, additional, and Huang, Shau-Ku, additional

Published
2018
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29. An Integrative Index for Predicting Extubation Outcomes After Successful Completion of a Spontaneous Breathing Trial in an Adult Medical Intensive Care Unit.

Author

Wu, Tsung-Ju, Shiao, Judith Shu-Chu, Yu, Hsin-Liang, and Lai, Ruay-Sheng

Subjects
ARTIFICIAL respiration, CONFIDENCE intervals, HEMOGLOBINS, INTENSIVE care units, LONGITUDINAL method, SCIENTIFIC observation, HEALTH outcome assessment, SERUM albumin, MECHANICAL ventilators, LOGISTIC regression analysis, ENDOTRACHEAL tubes, GLASGOW Coma Scale, ODDS ratio, ADULTS
Abstract

Background: Among respiratory predictors, rapid shallow breathing index (RSBI) has been a commonly used respiratory parameter to predict extubation outcomes. However, the outcome of prediction remains inconsistent. Regarding nonrespiratory predictors, serum albumin, hemoglobin, bicarbonate, and patients' alertness have been reported to be associated with successful weaning or extubation. We aimed to develop an integrative index combining commonly used predictors in the adult medical intensive care units (MICUs) and to compare the predictability of the index with RSBI. Methods: This prospective observational study with retrospective data collection of planned extubations was conducted in a 14-bed adult MICU. We enrolled patients who received mechanical ventilation via an endotracheal tube in the adult MICU for >24 hours and passed a 2-hour spontaneous breathing trial and underwent extubation. Extubation failure was defined as reinstitution of invasive mechanical ventilation within 48 hours of extubation. Respiratory parameters and Glasgow Coma Scale (GCS) scores of patients were recorded prospectively. Nonrespiratory parameters were recorded retrospectively. Logistic regression was used to determine significant predictors of extubation outcomes. Results: Fifty-nine patients comprising 70 extubations were enrolled. Extubation failure was significantly and positively associated with lower serum albumin (albumin < 2.6 g/dL, odds ratio [OR] = 5.1; 95% confidence interval [CI], 1.04-24.66), lower hemoglobin (hemoglobin < 10.0 g/dL, OR = 10.8; 95% CI, 2.00-58.04), and lower GCS scores (GCS score ≤ 8, OR = 6.1; 95% CI = 1.15-32.34). By using an integrative index combining the 3 parameters together, the sensitivity and specificity to predict extubation outcomes were 78.6% and 75.9%, respectively. The area under the receiver operating characteristic curve of the index was significantly higher than RSBI (0.84 vs 0.61, P =.026). Conclusion: The integrative index combining serum albumin, hemoglobin, and GCS scores could predict extubation outcomes better than RSBI in an adult MICU. [ABSTRACT FROM AUTHOR]

Published
2019
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30. High frequency of unusual gastric/duodenal ulcers in patients with Behçet's disease in Taiwan: a possible correlation of MHC molecules with the development of gastric/duodenal ulcers

Author

Lai Ruay-Sheng, Lai Ning-Sheng, and Tseng Kuo-Chih

Subjects
Adult, Male, medicine.medical_specialty, Peptic, Prevalence, Taiwan, Rapid urease test, Disease, Behcet's disease, Gastroenterology, Major Histocompatibility Complex, Rheumatology, Internal medicine, medicine, Humans, Stomach Ulcer, Aged, Gastrointestinal tract, business.industry, Behcet Syndrome, General Medicine, Middle Aged, medicine.disease, digestive system diseases, Duodenal Ulcer, Female, Vasculitis, business
Abstract

The gastrointestinal (GI) involvement of Behcet's disease (BD) mainly affects the ileocecal region and colon. The gastroduodenal mucosa appears to be the least frequently involved segment of the gastrointestinal tract. The objective of this study was to assess the severity of gastric/duodenal involvement in BD patients in Taiwan. Behcet's disease was diagnosed according to the diagnostic criteria issued by the International Study Group for Behcet's Disease. We obtained and recorded clinical and laboratory data. A routine endoscopic examination with a urease test for Helicobacter pylori infection was arranged. Furthermore, HLA tissue typing was also performed by polymerase chain reaction with sequence-specific primers to evaluate the possible genetic loads associated with ulcer development. A total 28 BD patients, diagnosed at DaLin TzuChi hospital from 1999 to 2002, were enrolled in this study. The prevalence rate of gastric/duodenal ulceration was 43% (six patients had combined gastric and duodenal ulcers, three patients had simple gastric ulcers, and three patients had simple duodenal ulcers). No risk factors of nonsteroidal anti-inflammatory drug (NSAID) or H. pylori infection were found to be associated with gastrointestinal ulcers in our BD patients. All patients with peptic ulcers responded well to systemic steroids and immunosuppressant treatment in this preliminary observation. Furthermore, 7 of 12 gastric/duodenal ulcer patients (58%) carried an A2/B46/Cw1 or A11/B46/Cw1 genotype. Our data indicated that gastric/duodenal ulcers were a common manifestation in Chinese patients with BD in Taiwan in close association with the distinct genotypes of A2/B46/Cw1 or A11/B46/Cw1. A good response to systemic steroids, rather than conventional H2 blockers, might be due to downregulation of the vasculitis.

Published
2004

32. ASPIRATION: Phase II study of continued erlotinib beyond RECIST progression in Asian patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC).

Author

Park, Keunchil, primary, Tsai, Chun-Ming, additional, Ahn, Myung-ju, additional, Yu, Chong-Jen, additional, Kim, Sang-We, additional, Sriuranpong, Virote, additional, Kuo, Han Pin, additional, Lee, Jong-Seok, additional, Kang, Jin Hyoung, additional, Lin, Meng-Chih, additional, Geater, Sarayut Lucien, additional, Chang, Gee-Chen, additional, Seetalarom, Kasan, additional, So, Ping Fai Peter, additional, Lai, Ruay-Sheng, additional, Cheng, Ashley Chi Kin, additional, Cho, Eun Kyung, additional, Chen, Shang-Hung, additional, Hsia, Te-Chun, additional, and Mok, Tony, additional

Published
2012
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39. Association of Sauropus androgynus and Bronchiolitis Obliterans Syndrome: A Hospital-based Case-Control Study.

Author

Ger, Luo-Ping, Chiang, Ambrose A., Lai, Ruay-Sheng, Chen, Su-Mei, and Tseng, Ching-Jiunn

Subjects
RESPIRATORY diseases, UNIVARIATE analysis, COOKING, LOGISTIC regression analysis
Abstract

In late April 1995, an outbreak of a poorly defined respiratory illness related to the ingestion of leaves of Sauropus androgynus was observed in southern Taiwan. To further evaluate the association between S. androgynus and bronchiolitis obliterans syndrome, a hospital-based case-control study was conducted with one case group and three different control groups at Veterans General Hospital-Kaohsiung between April and September 1995. A total of 54 cases (50 females, 4 males), 54 age- and sex- matched neighborhood controls, 54 matched routine physical check-up controls, and 54 matched self-referred patron controls (who had ingested S. androgynus yet without obstructive physiology) were interviewed for clinical symptoms, history of S. androgynus consumption, and potential confounding factors. All 54 cases (100%) ingested S. androgynus compared with only five (9%) neighborhood controls (matched odds ratio (OR) incalculable, p < 0.001) and two (4%) physical check-up controls (matched OR incalculable, p < 0.001). In the univariate analysis of 54 cases and 54 self-referred patron controls, factors associated with an increased risk of bronchiolitis obliterans syndrome were methods of food preparation (uncooked juice vs. stir fried or boiled dishes, matched OR 10.3 (95% confidence interval (Cl) 1.3–84.4)); preparer of the S. androgynus-containing food (vendor only vs. patient only or patient plus vendor, matched OR 2.8 (95% Cl 1.1–7.1)); total S. androgynus consumption quantity (>4, 500 vs. 413–2, 063 g, matched OR 10.0 (95% Cl 1.9–53.0)); duration of consumption (>45 vs. 6–24 days, matched OR 2.1 (95% Cl 1.2–3.8)); and midterm interruption (<2 vs. 2–5 days per week, matched OR 2.6 (95% Cl 1.1–6.1)). Additionally, multiple conditional logistic regression analysis of cases and self-referred patron controls revealed that a larger total amount of S. androgynus consumption, preparation of S. androgynus food without cooking, and ingesting S. androgynus food prepared by a vendor were the significant risk factors associated with bronchiolitis obliterans syndrome. Am J Epidemiol 1997; 145: 842-9. [ABSTRACT FROM AUTHOR]

Published
1997
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40. Churg-Strauss syndrome presenting with pulmonary capillaritis and diffuse alveolar hemorrhage.

Author

Lai, Ruay-Sheng, Lin, Shong-Ling, Lai, Ning-Sheng, Lee, Pei-Ching, Lai, R S, Lin, S L, Lai, N S, and Lee, P C

Subjects
*CHURG-Strauss syndrome, *PULMONARY circulation disorders, *ALVEOLAR process, *DISEASES, *ANTIGENS, *AUTOANTIBODIES, *CAPILLARIES, *HEMORRHAGE, *LUNGS, *LUNG diseases, *PROTEOLYTIC enzymes, *PULMONARY alveoli, *VASCULITIS, *DISEASE complications
Abstract

Churg-Strauss syndrome (CSS) is a rare disorder characterized by the histopathological triad of systemic necrotizing vasculitis, extravascular granuloma, and eosinophilic infiltrate, occurring in individuals with asthma or a history of allergy. We report a case of CSS with rare presentation of diffuse pulmonary hemorrhage. A transbronchial lung biopsy showed necrotizing vasculitis, pulmonary capillaritis, and prominent eosinophilic infiltrate. At autopsy, necrotizing granuloma and diffuse alveolar hemorrhage were found in the lungs. Laboratory data showed hypereosinophilia, disseminated intravascular coagulopathy, and positive anti-proteinase 3 antineutrophil cytoplasmic antibody (ANCA). This case emphasize that CSS should be considered in the differential diagnosis of ANCA-positive vasculitis with diffuse alveolar hemorrhage. [ABSTRACT FROM AUTHOR]

Published
1998
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42. Images in cardiovascular medicine. Scimitar syndrome with esophageal varices: magnetic resonance angiography detects anomalous pulmonary venous return.

Author

Wu MT, Lai RS, Huang YL, and Hsiao SH

Subjects
Adolescent, Angiography, Digital Subtraction, Esophagoscopy, Heart Atria surgery, Humans, Male, Pulmonary Veins surgery, Scimitar Syndrome complications, Scimitar Syndrome diagnostic imaging, Scimitar Syndrome pathology, Scimitar Syndrome surgery, Esophageal and Gastric Varices etiology, Gastrointestinal Hemorrhage etiology, Imaging, Three-Dimensional, Magnetic Resonance Angiography, Scimitar Syndrome diagnosis
Published
2004
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