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759 results on '"Lai, Po-Liang"'

31. Composite bone graft of CaO–MgO–SiO2 glass–ceramics and CaSO4 ceramics for boosting bone formation rate.

Author

Hung, Guan-Yi, Wang, Chi-Yun, Hsiao, Hui-Yi, Tu, Chi-Shun, Mana-ay, Haidee, Chen, Ching-Ting, Lai, Po-Liang, Feng, Kuei-Chih, and Chen, Pin-Yi

Abstract

This study develops a composite bone graft of CaO–MgO–SiO2 glass–ceramic and CaSO4 [abbreviated as (CMS)3−x(CS)x] via the sponge replication technique with weight fractions of x = 0, 1, 1.5, 2, and 3. The (CMS)1.5(CS)1.5 composite displays a superior degradability and, a suitable compressive strength of ∼3 MPa, and excellent cell proliferation and differentiation. The in vivo rat femur test in the hybrid-pore (CMS)1.5(CS)1.5 composite granules achieves a higher rate of bone formation, which is ∼2.7 times better than that of the commercial HAP/β-TCP at 12 weeks. Improved expressions of osteocyte and mature osteocyte marker genes, namely (Spp1, Dmp1, and Fgf23), were observed in the (CMS)1.5(CS)1.5 group, indicating a faster differentiation into mature bone tissue. The ions release of (CMS)1.5(CS)1.5 through the ERK1/2 signaling pathway promotes osteogenic differentiation. The high bone generation rate can be attributed to faster active ions release and modified surface topography. This work highlights an excellent bone graft candidate for clinical applications in orthopedic surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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44. The Effect of Different Size of Slicing Spheres of Polyaxial Screw Head on Static Compression Mechanical Test

Author

Liu, Po-Yi, Wang, Yu-Tzu, Wang, Hsien-Wen, Huang, Shao-Fu, Lin, Yang-Sung, Lai, Po-Liang, Lin, Chun-Li, Magjarevic, Ratko, Editor-in-chief, Ładyżyński, Piotr, Series editor, Ibrahim, Fatimah, Series editor, Lacković, Igor, Series editor, Rock, Emilio Sacristan, Series editor, Usman, Juliana, editor, Ahmad, Mohd Yazed, editor, Hamzah, Norhamizan, editor, and Teh, Swe Jyan, editor

Published
2018
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49. Local application of zoledronate inhibits early bone resorption and promotes bone formation.

Author

Hsieh, Ming-Kai, Wang, Chi-Yun, Kao, Fu-Cheng, Su, Hui-Ting, Chen, Mei-Feng, Tsai, Tsung-Ting, and Lai, Po-Liang

Subjects
BONE regeneration, BONE resorption, BONE growth, MESENCHYMAL stem cells, ZOLEDRONIC acid, C-Jun N-terminal kinases
Abstract

Nonunion resulting from early bone resorption is common after bone transplantation surgery. In these patients, instability or osteoporosis causes hyperactive catabolism relative to anabolism, leading to graft resorption instead of fusion. Systemic zoledronate administration inhibits osteoclastogenesis and is widely used to prevent osteoporosis; however, evidence on local zoledronate application is controversial due to osteoblast cytotoxicity, uncontrolled dosing regimens, and local release methods. We investigated the effects of zolendronate on osteoclastogenesis and osteogenesis and explored the corresponding signaling pathways. In vitro cytotoxicity and differentiation of MC3T3E1 cells, rat bone marrow stromal cells (BMSCs) and preosteoclasts (RAW264.7 cells) were evaluated with different zolendronate concentrations. In vivo bone regeneration ability was tested by transplanting different concentrations of zolendronate with β-tricalcium phosphate (TCP) bone substitute into rat femoral critical-sized bone defects. In vitro , zolendronate concentrations below 2.5 × 10-7 M did not compromise viability in the three cell lines and did not promote osteogenic differentiation in MC3T3E1 cells and BMSCs. In RAW264.7 cells, zoledronate inhibited extracellular regulated protein kinases and c-Jun n-terminal kinase signaling, downregulating c-Fos and NFATc1 expression, with reduced expression of fusion-related dendritic cell‑specific transmembrane protein and osteoclast-specific Ctsk and tartrate-resistant acid phosphatase (. In vivo , histological staining revealed increased osteoid formation and neovascularization and reduced fibrotic tissue with 500 μM and 2000 μM zolendronate. More osteoclasts were found in the normal saline group after 6 weeks, and sequential osteoclast formation occurred after zoledronate treatment, indicating inhibition of bone resorption during early callus formation without inhibition of late-stage bone remodeling. In vivo , soaking β-TCP artificial bone with 500 μM or 2000 μM zoledronate is a promising approach for bone regeneration, with potential applications in bone transplantation. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Microstructural characterization of Ce-TZP/Al2O3 after degradation in water.

Author

Tung, Che-Lun, Cheng, Yung-Shin, Tien, Chi-Shan, Hsu, Pei-Yi, Tuan, Wei-Hsing, Chen, Jin-Ren, Lai, Po-Liang, Wu, Ying-Ying, Shih, Shao-Ju, and Galusek, Dusan

Subjects
TRANSMISSION electron microscopy, SCANNING electron microscopy, ACOUSTIC emission testing
Abstract

In this study, the long-term resistance of Ce-TZP/Al2O3 specimens to hydrothermal treatment is evaluated in terms of their microstructure. Treatment of the specimens is carried out in an autoclave with water at 134°C for up to 360 h. The biaxial strength and Weibull modulus of the specimens remains unchanged after 120 h of hydrothermal treatment, and their pseudo-plasticity is preserved. However, after 360 h of hydrothermal treatment the biaxial strength decreases by 12% and the Weibull modulus is also decreased. The transformation surface layer is observed through scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The thickness of the transformation layer can be estimated only through TEM analysis, revealing minimal microcrack formation at the surface layer. For comparison, several Y-TZP specimens are also prepared. After 24 h of hydrothermal treatment, the monoclinic phase content in the Y-TZP specimen reached 60%, resulting in a 40% decrease in strength. This strength decrease can be attributed to microcrack formation in the surface layer. [ABSTRACT FROM AUTHOR]

Published
2024
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