1. Association between exposure to organophosphate flame retardants and epidermal growth factor receptor expression in lung cancer patients.
- Author
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Chen, Po‐Ju, Lai, Po‐Chen, Lu, Yueh‐Chien, Pan, Bo‐Lin, Huang, Wan‐Ting, Kung, Chia‐Te, Chiang, Jui‐Chin, Cheng, Fu‐Jen, Wang, Liang‐Jen, Li, Shau‐Hsuan, Lee, Wen‐Chin, Ou, Yu‐Che, and Wang, Chin‐Chou
- Subjects
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RISK assessment , *RESEARCH funding , *DATA analysis , *INHALATION injuries , *LOGISTIC regression analysis , *CANCER patients , *FIREPROOFING agents , *GENE expression , *LONGITUDINAL method , *CHRONIC kidney failure , *LUNG tumors , *ORGANOPHOSPHORUS compounds , *URINALYSIS , *STATISTICS , *COMPARATIVE studies , *EPIDERMAL growth factor receptors , *TOXICITY testing , *DISEASE risk factors - Abstract
Background: Organophosphate flame retardants (OPFRs) are extensively distributed in our environment, prompting concerns about potential health hazards, including lung injuries resulting from OPFR exposure. Methods: The present study recruited 125 lung cancer patients, assessing their exposure to 10 OPFR compounds through urine samples. The final analysis comprised 108 participants after excluding those lacking epidermal growth factor receptor (EGFR) status and those with chronic kidney disease. Demographic and clinical characteristics, as well as urinary OPFR concentrations, were compared based on OPFR detection. Spearman correlation was conducted to explore the relationship between OPFR compounds, while logistic regression was used to identify OPFR compounds associated with EGFR mutation. Results: The study revealed widespread OPFR exposure among lung cancer patients, with an overall detection frequency of 99.07%. Tris(2‐butoxyethyl) phosphate (TBEP) exhibited a strong correlation to its metabolite bis(2‐butoxyethyl) phosphate (r = 0.88, p < 0.01). Patients with TBEP in their urine had higher percentage of wild‐type EGFR and the detection of TBEP was associated with a reduced likelihood of mutant EGFR expression. Conclusions: OPFR exposure was prevalent in lung cancer patients, with TBEP detection identified as a factor with lower EGFR mutation expression. This study contributes to the understanding of OPFR exposure in lung cancer patients and underscores the significance of TBEP in evaluating EGFR mutation in this population. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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