886 results on '"Lai, Liangxue"'
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2. An optimized culture system for efficient derivation of porcine expanded potential stem cells from preimplantation embryos and by reprogramming somatic cells
3. Exonuclease editor promotes precision of gene editing in mammalian cells
4. Enhancing prime editor flexibility with coiled-coil heterodimers
5. Unraveling the role of Xist in X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A
6. Targeted mutagenesis in mice via an engineered AsCas12f1 system
7. A spatiotemporal atlas of mouse liver homeostasis and regeneration
8. Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing
9. Mild phototherapy mediated by IR780-Gd-OPN nanomicelles suppresses atherosclerotic plaque progression through the activation of the HSP27-regulated NF-κB pathway
10. A strategy for Cas13 miniaturization based on the structure and AlphaFold
11. Engineered domain-inlaid Nme2Cas9 adenine base editors with increased on-target DNA editing and targeting scope
12. A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9
13. Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation
14. Base editors: development and applications in biomedicine
15. A-to-G/C/T and C-to-T/G/A dual-function base editor for creating multi-nucleotide variants
16. Cas9-mediated replacement of expanded CAG repeats in a pig model of Huntington’s disease
17. Development of a highly efficient prime editor system in mice and rabbits
18. Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos
19. Multiple gene modifications of pigs for overcoming obstacles of xenotransplantation
20. YIPF5 (p.W218R) mutation induced primary microcephaly in rabbits
21. Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression
22. Transcriptome-wide identification of 5-methylcytosine by deaminase and reader protein-assisted sequencing
23. Dogs lacking Apolipoprotein E show advanced atherosclerosis leading to apparent clinical complications
24. Author Correction: Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
25. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing.
26. α-Gal antigen-deficient rabbits with GGTA1 gene disruption via CRISPR/Cas9
27. Multiplexed base editing through Cas12a variant-mediated cytosine and adenine base editors
28. Inhibition of base editors with anti-deaminases derived from viruses
29. Human induced-T-to-natural killer cells have potent anti-tumour activities
30. Versatile and efficient genome editing with Neisseria cinerea Cas9
31. Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites
32. Live imaging of RNA and RNA splicing in mammalian cells via the dcas13a-SunTag-BiFC system
33. Highly efficient A-to-G base editing by ABE8.17 in rabbits
34. A modified glycosylase base editor without predictable DNA off‐target effects.
35. Improvement of TaC9‐ABE mediated correction of human SMN2 gene.
36. MiR‐106a targets ATG7 to inhibit autophagy and angiogenesis after myocardial infarction
37. Precise large-fragment deletions in mammalian cells and mice generated by dCas9-controlled CRISPR/Cas3
38. Efficient and high-fidelity base editor with expanded PAM compatibility for cytidine dinucleotide
39. In vivo evaluation of guide-free Cas9-induced safety risks in a pig model.
40. Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase
41. In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers
42. Efficient and precise generation of Tay–Sachs disease model in rabbit by prime editing system
43. Author Correction: Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing
44. Generation of permanent neonatal diabetes mellitus dogs with glucokinase point mutations through base editing
45. Genetic deletion of a short fragment of glucokinase in rabbit by CRISPR/Cas9 leading to hyperglycemia and other typical features seen in MODY-2
46. Mutations of GADD45G in rabbits cause cleft lip by the disorder of proliferation, apoptosis and epithelial-mesenchymal transition (EMT)
47. Programmable RNA 5-methylcytosine (m5C) modification of cellular RNAs by dCasRx conjugated methyltransferase and demethylase.
48. Unraveling the role ofXistin X chromosome inactivation: insights from rabbit model and deletion analysis of exons and repeat A
49. Generation of a homozygous RANGRF knockout hiPSC line by CRISPR/Cas9 system
50. Expanded targeting scope and enhanced base editing efficiency in rabbit using optimized xCas9(3.7)
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