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672 results on '"Lai, Chien-Chen"'

5. Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation

Author

Xu, An, Liu, Mo, Huang, Mo-Fan, Zhang, Yang, Hu, Ruifeng, Gingold, Julian A., Liu, Ying, Zhu, Dandan, Chien, Chian-Shiu, Wang, Wei-Chen, Liao, Zian, Yuan, Fei, Hsu, Chih-Wei, Tu, Jian, Yu, Yao, Rosen, Taylor, Xiong, Feng, Jia, Peilin, Yang, Yi-Ping, Bazer, Danielle A., Chen, Ya-Wen, Li, Wenbo, Huff, Chad D., Zhu, Jay-Jiguang, Aguilo, Francesca, Chiou, Shih-Hwa, Boles, Nathan C., Lai, Chien-Chen, Hung, Mien-Chie, Zhao, Zhongming, Van Nostrand, Eric L., Zhao, Ruiying, and Lee, Dung-Fang

Published
2023
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11. Comparative proteomics analysis of female fibromyalgia and osteoarthritis using data‐independent acquisition sequential window acquisition of all theoretical mass spectra‐based mass spectrometry.

Author

Kuo, Cheng‐Yu, Tang, Kuo‐Tung, Wang, Wei‐Chen, Zheng, Yi‐Feng, Wu, Yi‐Ling, Chang, Chih‐Jui, and Lai, Chien‐Chen

Subjects
ACUTE phase reaction, ACUTE phase proteins, MYALGIA, COMPLEMENT activation, MASS spectrometry, SEROTONIN, DOPAMINE
Abstract

Fibromyalgia (FM) is a widespread muscle pain disorder that primarily affects females. Osteoarthritis (OA) is another common chronic condition. This study utilized sequential window acquisition of all theoretical mass spectra (SWATH)‐based proteomic analysis on the urine of patients with FM and OA. The study identified 54 differentially expressed proteins (DEPs) in the FM group compared to the healthy control (HC) group; 17 DEPs in the OA group compared to the HC group; and 47 DEPs in the FM group compared to the OA group, with a p‐value <0.05 and a fold change >1.5 or <0.67. The DEPs in both FM and OA groups were primarily involved in pathways related to coagulation and the complement system, as well as serotonin, dopamine, glutamate pathways, and acute phase reactions. The study suggests that FM and OA induce inflammatory reactions, significantly altering the expression of acute phase proteins and notably decreasing the expression of GNB2. This distinction between health and disease, and the differentiation between FM and OA, is facilitated through the coagulation and complement systems, with SERPING1 and EPCR being key markers. Through these pathways, a better understanding of the impact of FM and OA on the human proteome is achieved. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Salivary Gland Sonography in Patients with Primary Fibromyalgia—A Pilot Study.

Author

Lin, Ching-Tsai, Chen, Der-Yuan, Chen, Yi-Hsing, Lai, Chien-Chen, and Tang, Kuo-Tung

Subjects
SJOGREN'S syndrome, DRY eye syndromes, SLEEP quality, CHI-squared test, ULTRASONIC imaging
Abstract

Primary Sjogren's syndrome (pSS) is often concomitant with fibromyalgia (FM). Salivary gland sonography aids in the diagnosis of pSS. We aimed to discover, in primary FM patients, the presence of pSS in undiagnosed patients through salivary gland sonography. We prospectively recruited 42 primary FM patients. FM symptoms were evaluated based on the revised Fibromyalgia Impact Questionnaire (FIQR). Salivary gland sonography was performed. Patients with positive findings underwent salivary gland biopsy. Comparisons were undertaken using the Mann–Whitney U tests and Chi-squared test. In primary FM patients, the prevalence of dry eye was 83%, and dry mouth was 90%. The salivary gland sonographic score did not differ between patients with and without dry eye/mouth. One patient with a positive finding at salivary gland sonography had a positive result of salivary gland biopsy. In the other four patients who received salivary gland biopsy, despite negative findings in salivary gland sonography, only one had a positive result of salivary gland biopsy. To be noted, scores evaluated by salivary gland sonography were negatively associated with levels of pain (rho = −0.360, p= 0.023) and levels of sleep quality (rho = −0.447, p = 0.004). Our pilot study demonstrated the potential of salivary gland biopsy in detecting undiagnosed pSS in primary FM patients. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Exposure to Volatile Organic Compounds May Contribute to Atopic Dermatitis in Adults.

Author

Tang, Kuo-Tung, Chen, Yu-Sin, Lee, Mey-Fann, Chen, Tzu-Ting, Lai, Chien-Chen, Lin, Chi-Chien, and Chen, Yi-Hsing

Subjects
VOLATILE organic compounds, AIR pollutants, ATOPIC dermatitis, ALLERGIES, AIR pollution
Abstract

Background: Volatile organic compounds (VOC) are major indoor air pollutants. Previous studies reported an association between VOC exposure and allergic diseases. Here, we aimed to explore the relationship between VOC exposure and atopic dermatitis (AD) in adults. Methods: We prospectively enrolled 31 adult AD patients and 11 healthy subjects as controls. Urine metabolite levels of VOCs, including 1.3-butadiene, acrylamide, benzene, toluene, and xylene, were all determined with liquid chromatography–mass spectrometry. The relationship between AD and log-transformed urine levels of VOC metabolites were examined using a multivariate linear regression model adjusted for age and sex. We also treated mouse bone marrow-derived cells (BMMCs) with 1,3-butadiene and toluene and measured the release of β-hexosaminidase. Results: Our results demonstrated that creatinine-corrected urine levels of N-Acetyl-S- (3,4-dihydroxybutyl)-L-cysteine (DHBMA), N-Acetyl-S-(2-carbamoyl-2-hydroxyethyl)-L-cysteine (GAMA), and N-Acetyl-S-(benzyl)-L-cysteine (BMA) were all elevated in AD patients compared with controls. In a multivariate linear regression model, creatinine-corrected urine levels of BMA (a toluene metabolite) and DHBMA (a 1,3-butadiene metabolite) appeared elevated in AD patients, although statistical significance was not reached after correction for multiple comparisons. In addition, 1,3-butadiene and toluene could stimulate BMMCs to degranulate as much as compound 48/80. Conclusions: Some VOCs, such as 1,3-butadiene and toluene, might be associated with AD pathogenesis in adults. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Exon Junction Complex Mediates the Cap-Independent Translation of Circular RNA

Author

Lin, Hui-Hsuan, primary, Chang, Chiu-Yuan, additional, Huang, Yi-Ren, additional, Shen, Che-Hung, additional, Wu, Yu-Chen, additional, Chang, Kai-Li, additional, Lee, Yueh-Chun, additional, Lin, Ya-Chi, additional, Ting, Wen-Chien, additional, Chien, Han-Ju, additional, Zheng, Yi-Feng, additional, Lai, Chien-Chen, additional, and Hsiao, Kuei-Yang, additional

Published
2023
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27. Data from AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

Author

Li, Chia-Wei, primary, Xia, Weiya, primary, Lim, Seung-Oe, primary, Hsu, Jennifer L., primary, Huo, Longfei, primary, Wu, Yun, primary, Li, Long-Yuan, primary, Lai, Chien-Chen, primary, Chang, Shih-Shin, primary, Hsu, Yi-Hsin, primary, Sun, Hui-Lung, primary, Kim, Jongchan, primary, Yamaguchi, Hirohito, primary, Lee, Dung-Fang, primary, Wang, Hongmei, primary, Wang, Yan, primary, Chou, Chao-Kai, primary, Hsu, Jung-Mao, primary, Lai, Yun-Ju, primary, LaBaff, Adam M., primary, Ding, Qingqing, primary, Ko, How-Wen, primary, Tsai, Fuu-Jen, primary, Tsai, Chang-Hai, primary, Hortobagyi, Gabriel N., primary, and Hung, Mien-Chie, primary

Published
2023
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28. Data from Nuclear ErbB2 Enhances Translation and Cell Growth by Activating Transcription of Ribosomal RNA Genes

Author

Li, Long-Yuan, primary, Chen, Hsiuyi, primary, Hsieh, Yi-Hsien, primary, Wang, Ying-Nai, primary, Chu, Hsiao-Ju, primary, Chen, Ya-Huey, primary, Chen, Hui-Yu, primary, Chien, Peng-Ju, primary, Ma, Haou-Tzong, primary, Tsai, Ho-Cheng, primary, Lai, Chien-Chen, primary, Sher, Yuh-Pyng, primary, Lien, Huang-Chun, primary, Tsai, Chang-Hai, primary, and Hung, Mien-Chie, primary

Published
2023
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29. Supplementary Methods, Figures 1-5 from Nuclear ErbB2 Enhances Translation and Cell Growth by Activating Transcription of Ribosomal RNA Genes

Author

Li, Long-Yuan, primary, Chen, Hsiuyi, primary, Hsieh, Yi-Hsien, primary, Wang, Ying-Nai, primary, Chu, Hsiao-Ju, primary, Chen, Ya-Huey, primary, Chen, Hui-Yu, primary, Chien, Peng-Ju, primary, Ma, Haou-Tzong, primary, Tsai, Ho-Cheng, primary, Lai, Chien-Chen, primary, Sher, Yuh-Pyng, primary, Lien, Huang-Chun, primary, Tsai, Chang-Hai, primary, and Hung, Mien-Chie, primary

Published
2023
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30. Data from Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

Author

Ding, Qingqing, primary, Huo, Longfei, primary, Yang, Jer-Yen, primary, Xia, Weiya, primary, Wei, Yongkun, primary, Liao, Yong, primary, Chang, Chun-Ju, primary, Yang, Yan, primary, Lai, Chien-Chen, primary, Lee, Dung-Fang, primary, Yen, Chia-Jui, primary, Chen, Yun-Ju Rita, primary, Hsu, Jung-Mao, primary, Kuo, Hsu-Ping, primary, Lin, Chun-Yi, primary, Tsai, Fuu-Jen, primary, Li, Long-Yuan, primary, Tsai, Chang-Hai, primary, and Hung, Mien-Chie, primary

Published
2023
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31. Supplementary Materials and Methods from AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

Author

Li, Chia-Wei, primary, Xia, Weiya, primary, Lim, Seung-Oe, primary, Hsu, Jennifer L., primary, Huo, Longfei, primary, Wu, Yun, primary, Li, Long-Yuan, primary, Lai, Chien-Chen, primary, Chang, Shih-Shin, primary, Hsu, Yi-Hsin, primary, Sun, Hui-Lung, primary, Kim, Jongchan, primary, Yamaguchi, Hirohito, primary, Lee, Dung-Fang, primary, Wang, Hongmei, primary, Wang, Yan, primary, Chou, Chao-Kai, primary, Hsu, Jung-Mao, primary, Lai, Yun-Ju, primary, LaBaff, Adam M., primary, Ding, Qingqing, primary, Ko, How-Wen, primary, Tsai, Fuu-Jen, primary, Tsai, Chang-Hai, primary, Hortobagyi, Gabriel N., primary, and Hung, Mien-Chie, primary

Published
2023
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32. Supplementary Figure 3 from Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

Author

Ding, Qingqing, primary, Huo, Longfei, primary, Yang, Jer-Yen, primary, Xia, Weiya, primary, Wei, Yongkun, primary, Liao, Yong, primary, Chang, Chun-Ju, primary, Yang, Yan, primary, Lai, Chien-Chen, primary, Lee, Dung-Fang, primary, Yen, Chia-Jui, primary, Chen, Yun-Ju Rita, primary, Hsu, Jung-Mao, primary, Kuo, Hsu-Ping, primary, Lin, Chun-Yi, primary, Tsai, Fuu-Jen, primary, Li, Long-Yuan, primary, Tsai, Chang-Hai, primary, and Hung, Mien-Chie, primary

Published
2023
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33. Supplementary Figure Legends from AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

Author

Li, Chia-Wei, primary, Xia, Weiya, primary, Lim, Seung-Oe, primary, Hsu, Jennifer L., primary, Huo, Longfei, primary, Wu, Yun, primary, Li, Long-Yuan, primary, Lai, Chien-Chen, primary, Chang, Shih-Shin, primary, Hsu, Yi-Hsin, primary, Sun, Hui-Lung, primary, Kim, Jongchan, primary, Yamaguchi, Hirohito, primary, Lee, Dung-Fang, primary, Wang, Hongmei, primary, Wang, Yan, primary, Chou, Chao-Kai, primary, Hsu, Jung-Mao, primary, Lai, Yun-Ju, primary, LaBaff, Adam M., primary, Ding, Qingqing, primary, Ko, How-Wen, primary, Tsai, Fuu-Jen, primary, Tsai, Chang-Hai, primary, Hortobagyi, Gabriel N., primary, and Hung, Mien-Chie, primary

Published
2023
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34. Supplementary Figure 2 from Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

Author

Ding, Qingqing, primary, Huo, Longfei, primary, Yang, Jer-Yen, primary, Xia, Weiya, primary, Wei, Yongkun, primary, Liao, Yong, primary, Chang, Chun-Ju, primary, Yang, Yan, primary, Lai, Chien-Chen, primary, Lee, Dung-Fang, primary, Yen, Chia-Jui, primary, Chen, Yun-Ju Rita, primary, Hsu, Jung-Mao, primary, Kuo, Hsu-Ping, primary, Lin, Chun-Yi, primary, Tsai, Fuu-Jen, primary, Li, Long-Yuan, primary, Tsai, Chang-Hai, primary, and Hung, Mien-Chie, primary

Published
2023
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35. Supplementary Figure 1 from Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

Author

Ding, Qingqing, primary, Huo, Longfei, primary, Yang, Jer-Yen, primary, Xia, Weiya, primary, Wei, Yongkun, primary, Liao, Yong, primary, Chang, Chun-Ju, primary, Yang, Yan, primary, Lai, Chien-Chen, primary, Lee, Dung-Fang, primary, Yen, Chia-Jui, primary, Chen, Yun-Ju Rita, primary, Hsu, Jung-Mao, primary, Kuo, Hsu-Ping, primary, Lin, Chun-Yi, primary, Tsai, Fuu-Jen, primary, Li, Long-Yuan, primary, Tsai, Chang-Hai, primary, and Hung, Mien-Chie, primary

Published
2023
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36. Supplementary Tables and Figures from AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation

Author

Li, Chia-Wei, primary, Xia, Weiya, primary, Lim, Seung-Oe, primary, Hsu, Jennifer L., primary, Huo, Longfei, primary, Wu, Yun, primary, Li, Long-Yuan, primary, Lai, Chien-Chen, primary, Chang, Shih-Shin, primary, Hsu, Yi-Hsin, primary, Sun, Hui-Lung, primary, Kim, Jongchan, primary, Yamaguchi, Hirohito, primary, Lee, Dung-Fang, primary, Wang, Hongmei, primary, Wang, Yan, primary, Chou, Chao-Kai, primary, Hsu, Jung-Mao, primary, Lai, Yun-Ju, primary, LaBaff, Adam M., primary, Ding, Qingqing, primary, Ko, How-Wen, primary, Tsai, Fuu-Jen, primary, Tsai, Chang-Hai, primary, Hortobagyi, Gabriel N., primary, and Hung, Mien-Chie, primary

Published
2023
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40. Determination of adulteration, geographical origins, and species of food by mass spectrometry.

Author

Chien, Han‐Ju, Zheng, Yi‐Feng, Wang, Wei‐Chen, Kuo, Cheng‐Yu, Hsu, Yu‐Ming, and Lai, Chien‐Chen

Subjects
FOOD adulteration, ADULTERATIONS, FOOD labeling, FRAUD, METABOLOMICS
Abstract

Food adulteration, mislabeling, and fraud, are rising global issues. Therefore, a number of precise and reliable analytical instruments and approaches have been proposed to ensure the authenticity and accurate labeling of food and food products by confirming that the constituents of foodstuffs are of the kind and quality claimed by the seller and manufacturer. Traditional techniques (e.g., genomics‐based methods) are still in use; however, emerging approaches like mass spectrometry (MS)‐based technologies are being actively developed to supplement or supersede current methods for authentication of a variety of food commodities and products. This review provides a critical assessment of recent advances in food authentication, including MS‐based metabolomics, proteomics and other approaches. [ABSTRACT FROM AUTHOR]

Published
2023
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