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4. Decreased spermatogonial numbers in boys with severe haematological diseases

Author

Lahtinen, Atte K., primary, Funke, Miriam, additional, Krallmann, Claudia, additional, Wyrwoll, Margot J., additional, Jarisch, Andrea, additional, Yang, Yifan, additional, Bjarnason, Ragnar, additional, Romerius, Patrik, additional, Sundin, Mikael, additional, Norén‐Nyström, Ulrika, additional, Langenskiöld, Cecilia, additional, Cremers, Jann‐Frederik, additional, Kliesch, Sabine, additional, Stukenborg, Jan‐Bernd, additional, Neuhaus, Nina, additional, and Jahnukainen, Kirsi, additional

Published
2024
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6. Decreased spermatogonial numbers in boys with severe haematological diseases

Author

Lahtinen, Atte K., Funke, Miriam, Krallmann, Claudia, Wyrwoll, Margot J., Jarisch, Andrea, Yang, Yifan, Bjarnason, Ragnar, Romerius, Patrik, Sundin, Mikael, Norén-Nyström, Ulrika, Langenskiöld, Cecilia, Cremers, Jann-Frederik, Kliesch, Sabine, Stukenborg, Jan-Bernd, Neuhaus, Nina, Jahnukainen, Kirsi, Lahtinen, Atte K., Funke, Miriam, Krallmann, Claudia, Wyrwoll, Margot J., Jarisch, Andrea, Yang, Yifan, Bjarnason, Ragnar, Romerius, Patrik, Sundin, Mikael, Norén-Nyström, Ulrika, Langenskiöld, Cecilia, Cremers, Jann-Frederik, Kliesch, Sabine, Stukenborg, Jan-Bernd, Neuhaus, Nina, and Jahnukainen, Kirsi

Abstract

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.

Published
2024
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7. CHEK2 GERMLINE VARIANTS AND ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT OUTCOMES

Author

Lahtinen, Atte K, primary, Koski, Jessica, additional, Ritari, Jarmo, additional, Hyvärinen, Kati, additional, Koskela, Satu, additional, Partanen, Jukka, additional, Vettenranta, Kim, additional, Koskenvuo, Minna, additional, Niittyvuopio, Riitta, additional, Salmenniemi, Urpu, additional, Itälä-Remes, Maija, additional, Jahnukainen, Kirsi, additional, Kilpivaara, Outi, additional, Wartiovaara- Kautto, Ulla, additional, and Karu, Maarja, additional

Published
2023
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9. Clinically relevant germline variants in allogeneic hematopoietic stem cell transplant recipients

Author

Lahtinen, Atte K., primary, Koski, Jessica, additional, Ritari, Jarmo, additional, Hyvärinen, Kati, additional, Koskela, Satu, additional, Partanen, Jukka, additional, Vettenranta, Kim, additional, Koskenvuo, Minna, additional, Niittyvuopio, Riitta, additional, Salmenniemi, Urpu, additional, Itälä-Remes, Maija, additional, Jahnukainen, Kirsi, additional, Kilpivaara, Outi, additional, and Wartiovaara-Kautto, Ulla, additional

Published
2022
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10. Early testicular maturation is sensitive to depletion of spermatogonial pool in sickle cell disease

Author

Benninghoven-Frey, Klara M., primary, Neuhaus, Nina, additional, Lahtinen, Atte K., additional, Krallmann, Claudia, additional, Portela, Joana M.D., additional, Jarisch, Andrea, additional, Nordhoff, Verena, additional, Soave, Armin, additional, Ba Omar, Hajar A.M., additional, Sundin, Mikael, additional, Langenskiöld, Cecilia, additional, Kliesch, Sabine, additional, Stukenborg, Jan-Bernd, additional, and Jahnukainen, Kirsi, additional

Published
2021
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