Search

Your search keyword '"Lahortiga, Idoya"' showing total 163 results
Start Over Author "Lahortiga, Idoya"
163 results on '"Lahortiga, Idoya"'

1. Data from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
Full Text
View/download PDF

2. Supplementary Tables from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
Full Text
View/download PDF

3. Supplementary Figures from CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, primary, Osada, Hirotaka, primary, Sun, Ruping, primary, Menon, Roopika, primary, Leenders, Frauke, primary, Ortiz-Cuaran, Sandra, primary, Peifer, Martin, primary, Bos, Marc, primary, Daßler, Juliane, primary, Malchers, Florian, primary, Schöttle, Jakob, primary, Vogel, Wenzel, primary, Dahmen, Ilona, primary, Koker, Mirjam, primary, Ullrich, Roland T., primary, Wright, Gavin M., primary, Russell, Prudence A., primary, Wainer, Zoe, primary, Solomon, Benjamin, primary, Brambilla, Elisabeth, primary, Nagy-Mignotte, Hélène, primary, Moro-Sibilot, Denis, primary, Brambilla, Christian G., primary, Lantuejoul, Sylvie, primary, Altmüller, Janine, primary, Becker, Christian, primary, Nürnberg, Peter, primary, Heuckmann, Johannes M., primary, Stoelben, Erich, primary, Petersen, Iver, primary, Clement, Joachim H., primary, Sänger, Jörg, primary, Muscarella, Lucia A., primary, la Torre, Annamaria, primary, Fazio, Vito M., primary, Lahortiga, Idoya, primary, Perera, Timothy, primary, Ogata, Souichi, primary, Parade, Marc, primary, Brehmer, Dirk, primary, Vingron, Martin, primary, Heukamp, Lukas C., primary, Buettner, Reinhard, primary, Zander, Thomas, primary, Wolf, Jürgen, primary, Perner, Sven, primary, Ansén, Sascha, primary, Haas, Stefan A., primary, Yatabe, Yasushi, primary, and Thomas, Roman K., primary

Published
2023
Full Text
View/download PDF

6. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Author

De Keersmaecker, Kim, Atak, Zeynep Kalender, Li, Ning, Vicente, Carmen, Patchett, Stephanie, Girardi, Tiziana, Gianfelici, Valentina, Geerdens, Ellen, Clappier, Emmanuelle, Porcu, Michaël, Lahortiga, Idoya, Lucà, Rossella, Yan, Jiekun, Hulselmans, Gert, Vranckx, Hilde, Vandepoel, Roel, Sweron, Bram, Jacobs, Kris, Mentens, Nicole, Wlodarska, Iwona, Cauwelier, Barbara, Cloos, Jacqueline, Soulier, Jean, Uyttebroeck, Anne, Bagni, Claudia, Hassan, Bassem A, Vandenberghe, Peter, Johnson, Arlen W, Aerts, Stein, and Cools, Jan

Published
2013
Full Text
View/download PDF

7. Overexpression of sPRDM16 coupled with loss of p53 induces myeloid leukemias in mice

Author

Shing, Danielle C., Trubia, Maurizio, Marchesi, Francesco, Radaelli, Enrico, Belloni, Elena, Tapinassi, Cinzia, Scanziani, Eugenio, Mecucci, Cristina, Crescenzi, Barbara, Lahortiga, Idoya, Odero, Maria D., Zardo, Giuseppe, Gruszka, Alicja, Minucci, Saverio, Fiore, Pier Paolo Di, and Pelicci, Pier Giuseppe

Subjects
Chromosome abnormalities -- Complications and side effects, Chromosome abnormalities -- Research, Stem cells -- Health aspects
Abstract

Transgenic expression of the abnormal products of acute myeloid leukemia-associated (AML-associated) primary chromosomal translocations in hematopoietic stem/progenitor cells initiates leukemogenesis in mice, yet additional mutations are needed for leukemia development. We report here aberrant expression of PR domain containing 16 (PRDM16) in AML cells with either translocations of 1p36 or normal karyotype. These carried, respectively, relatively high prevalence of mutations in the TP53 tumor suppressor gene and in the nucleophosmin (NPM) gene, which regulates p53. Two protein isoforms are expressed from PRDM16, which differ in the presence or absence of the PR domain. Overexpression of the short isoform, sPRDM16, in mouse bone marrow induced AML with full penetrance, but only in the absence of p53. The mouse leukemias were characterized by multilineage cellular abnormalities and megakaryocyte dysplasia, a common feature of human AMLs with 1p36 translocations or NPM mutations. Overexpression of sPRDM16 increased the pool of HSCs in vivo, and in vitro blocked myeloid differentiation and prolonged progenitor life span. Loss of p53 augmented the effects of sPRDM16 on stem cell number and induced immortalization of progenitors. Thus, overexpression of sPRDM16 induces abnormal growth of stem cells and progenitors and cooperates with disruption of the p53 pathway in the induction of myeloid leukemia., Introduction Acute myeloid leukemia (AML) is initiated and maintained by a population of leukemic stem cells (SCs) that have an innate or acquired ability to self renew and is characterized [...]

Published
2007

13. Novel translocations that disrupt the platelet-derived growth factor receptor β (PDGFRB) gene in BCR–ABL-negative chronic myeloproliferative disorders

Author

BAXTER, E. JOANNA, KULKARNI, SHASHIKANT, VIZMANOS, JOSÉ-LUIS, JAJU, RINA, MARTINELLI, GIOVANNI, TESTONI, NICOLETTA, HUGHES, GEORGE, SALAMANCHUK, ZORYANA, CALASANZ, MARIA JOSÉ, LAHORTIGA, IDOYA, POCOCK, CHRISTOPHER F., DANG, RAYMOND, FIDLER, CARRIE, WAINSCOAT, JAMES S., BOULTWOOD, JACQUELINE, and CROSS, NICHOLAS C. P.

Published
2003

15. Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia

Author

Vázquez, Iria, Maicas, Miren, Cervera, José, Agirre, Xabier, Marin-Béjar, Oskar, Marcotegui, Nerea, Vicente, Carmen, Lahortiga, Idoya, Gomez-Benito, Maria, Carranza, Claudia, Valencia, Ana, Brunet, Salut, Lumbreras, Eva, Prosper, Felipe, Gomez Casares, Maria Teresa, Hernández Rivas, Jesús María, Calasanz, M.J, Sanz, Miguel A.., Sierra Gil, Jorge, Odero, María D., and Universitat Autònoma de Barcelona

Subjects
Male, Histone H3 Lysine 4, Down-Regulation, Kaplan-Meier Estimate, Epigenesis, Genetic, Histone H3, AML, Cell Line, Tumor, Proto-Oncogenes, Humans, Epigenetics, Cancer epigenetics, Aged, Regulation of gene expression, Aged, 80 and over, Gene Rearrangement, 3q, biology, epigenetics, Gene Expression Regulation, Leukemic, Gene Expression Profiling, Myeloid leukemia, HDAC8, Hematology, Original Articles, Middle Aged, Prognosis, MDS1 and EVI1 Complex Locus Protein, EVI1, DNA-Binding Proteins, Alternative Splicing, Leukemia, Myeloid, Acute, Histone, Cancer research, biology.protein, Female, Chromosomes, Human, Pair 3, overexpression, Transcription Factors
Abstract

[Background]: The EVI1 gene (3q26) codes for a zinc finger transcription factor with important roles in both mammalian development and leukemogenesis. Over-expression of EVI1 through either 3q26 rearrangements, MLL fusions, or other unknown mechanisms confers a poor prognosis in acute myeloid leukemia. [Design and Methods]: We analyzed the prevalence and prognostic impact of EVI1 over-expression in a series of 476 patients with acute myeloid leukemia, and investigated the epigenetic modifications of the EVI1 locus which could be involved in the transcriptional regulation of this gene. [Results]: Our data provide further evidence that EVI1 over-expression is a poor prognostic marker in acute myeloid leukemia patients less than 65 years old. Moreover, we found that patients with no basal expression of EVI1 had a better prognosis than patients with expression/over-expression (P=0.036). We also showed that cell lines with over-expression of EVI1 had no DNA methylation in the promoter region of the EVI1 locus, and had marks of active histone modifications: H3 and H4 acetylation, and trimethylation of histone H3 lysine 4. Conversely, cell lines with no expression of EVI1 have DNA hypermethylation and are marked by repressive trimethylation of histone H3 lysine 27 at the EVI1 promoter. [Conclusions]: Our results identify EVI1 over-expression as a poor prognostic marker in a large, independent cohort of acute myeloid leukemia patients less than 65 years old, and show that the total absence of EVI1 expression has a prognostic impact on the outcome of such patients. Furthermore, we demonstrated for the first time that an aberrant epigenetic pattern involving DNA methylation, H3 and H4 acetylation, and trimethylation of histone H3 lysine 4 and histone H3 lysine 27 might play a role in the transcriptional regulation of EVI1 in acute myeloid leukemia. This study opens new avenues for a better understanding of the regulation of EVI1 expression at a transcriptional level., This work was supported by a grant of Ministerio Educación y Ciencia (SAF2005/06425), Ministerio Ciencia e Innovación (PI081687), AECC, Departamento Salud del Gobierno de Navarra (14/2008), Generalitat de Catalunya (2009-SGR-1246), Fundación Cellex, SACYL (355/4/09), ISCIII-RTICC (RD06/0020/0078, RD06/0020/0101, RD06/0020/0006, RD06/0020/0031), and Fundación para la Investigación Médica Aplicada y UTE (Spain).

Published
2011

16. Quantitative Phosphoproteomics Analysis of ERBB3/ERBB4 Signaling

Author

Wandinger, Sebastian K., primary, Lahortiga, Idoya, additional, Jacobs, Kris, additional, Klammer, Martin, additional, Jordan, Nicole, additional, Elschenbroich, Sarah, additional, Parade, Marc, additional, Jacoby, Edgar, additional, Linders, Joannes T. M., additional, Brehmer, Dirk, additional, Cools, Jan, additional, and Daub, Henrik, additional

Published
2016
Full Text
View/download PDF

17. Molecular heterogeneity in AML/MDS patients with 3q21q26 rearrangements

Author

Lahortiga, Idoya, Vázquez, Iria, Agirre, Xabier, Larrayoz, María J., Vizmanos, José L., Gozzetti, Alessandro, Calasanz, María J., and Odero, María D.

Subjects
Myeloid, Adult, Male, Megakaryoblastic, Cancer Research, Acute, Chromosomes, Fluorescence, Leukemia, Myelomonocytic, Acute, Genetic Heterogeneity, Genetic, Leukemia, Megakaryoblastic, Acute, Genetics, Humans, In Situ Hybridization, In Situ Hybridization, Fluorescence, Aged, Leukemic, Recombination, Genetic, Leukemia, Monocytic, Acute Disease, Chromosome Banding, Chromosomes, Human, Pair 3, Female, Gene Expression Regulation, Leukemic, Karyotyping, Leukemia, Monocytic, Acute, Leukemia, Myeloid, Leukemia, Myeloid, Acute, Middle Aged, Myelodysplastic Syndromes, Myelomonocytic, Recombination, Gene Expression Regulation, Pair 3, Human
Abstract

Patients with 3q21q26 rearrangements seem to share similar clinicopathologic features and a common molecular mechanism, leading to myelodysplasia or acute myeloid leukemia (AML). The ectopic expression of EVI1 (3q26) has been implicated in the dysplasia that characterizes this subset of myeloid neoplasias. However, lack of EVI1 expression has been reported in several cases, and overexpression of EVI1 was detected in 9% of AML cases without 3q26 abnormalities. We report the molecular characterization of seven patients with inv(3)(q21q26), t(3;3)(q21;q26) or related abnormalities. EVI1 expression was detected in only one case, and thus ectopic expression of this gene failed to explain all of these cases. GATA2 (3q21) was found to be overexpressed in 5 of the 7 patients. GATA2 is highly expressed in stem cells, and its expression dramatically decreases when erythroid and megakaryocytic differentiation proceeds. No mutations in GATA1 were found in any patient, excluding loss of function of GATA1 as the cause of GATA2 overexpression. We report finding molecular heterogeneity in patients with 3q21q26 rearrangements in both breakpoints and in the expression pattern of the genes near these breakpoints. Our data suggest that a unique mechanism is not likely to be involved in 3q21q26 rearrangements.

Published
2004

18. CD74-NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, Plenker, Dennis, Osada, Hirotaka, Sun, Ruping, Menon, Roopika, Leenders, Frauke, Ortiz-Cuaran, Sandra, Peifer, Martin, Bos, Marc, Dassler, Juliane, Malchers, Florian, Schottle, Jakob, Vogel, Wenzel, Dahmen, Ilona, Koker, Mirjam, Ullrich, Roland T., Wright, Gavin M., Russell, Prudence A., Wainer, Zoe, Solomon, Benjamin, Brambilla, Elisabeth, Nagy-Mignotte, Helene, Moro-Sibilot, Denis, Brambilla, Christian G., Lantuejoul, Sylvie, Altmuller, Janine, Becker, Christian, Nurnberg, Peter, Heuckmann, Johannes M., Stoelben, Erich, Petersen, Iver, Clement, Joachim H., Saenger, Joerg, Muscarella, Lucia A., la Torre, Annamaria, Fazio, Vito M., Lahortiga, Idoya, Perera, Timothy, Ogata, Souichi, Parade, Marc, Brehmer, Dirk, Vingron, Martin, Heukamp, Lukas C., Buettner, Reinhard, Zander, Thomas, Wolf, Jurgen, Perner, Sven, Ansen, Sascha, Haas, Stefan A., Yatabe, Yasushi, Thomas, Roman K., Fernandez-Cuesta, Lynnette, Plenker, Dennis, Osada, Hirotaka, Sun, Ruping, Menon, Roopika, Leenders, Frauke, Ortiz-Cuaran, Sandra, Peifer, Martin, Bos, Marc, Dassler, Juliane, Malchers, Florian, Schottle, Jakob, Vogel, Wenzel, Dahmen, Ilona, Koker, Mirjam, Ullrich, Roland T., Wright, Gavin M., Russell, Prudence A., Wainer, Zoe, Solomon, Benjamin, Brambilla, Elisabeth, Nagy-Mignotte, Helene, Moro-Sibilot, Denis, Brambilla, Christian G., Lantuejoul, Sylvie, Altmuller, Janine, Becker, Christian, Nurnberg, Peter, Heuckmann, Johannes M., Stoelben, Erich, Petersen, Iver, Clement, Joachim H., Saenger, Joerg, Muscarella, Lucia A., la Torre, Annamaria, Fazio, Vito M., Lahortiga, Idoya, Perera, Timothy, Ogata, Souichi, Parade, Marc, Brehmer, Dirk, Vingron, Martin, Heukamp, Lukas C., Buettner, Reinhard, Zander, Thomas, Wolf, Jurgen, Perner, Sven, Ansen, Sascha, Haas, Stefan A., Yatabe, Yasushi, and Thomas, Roman K.

Abstract

We discovered a novel somatic gene fusion, CD74-NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas negative for known oncogenic alterations, we found four additional fusion-positive tumors, all of which were of the invasive mucinous subtype. Mechanistically, CD74-NRG1 leads to extracellular expression of the EGF-like domain of NRG1 III- ss 3, thereby providing the ligand for ERBB2-ERBB3 receptor complexes. Accordingly, ERBB2 and ERBB3 expression was high in the index case, and expression of phospho-ERBB3 was specifically found in tumors bearing the fusion ( P < 0.0001). Ectopic expression of CD74-NRG1 in lung cancer cell lines expressing ERBB2 and ERBB3 activated ERBB3 and the PI3K-AKT pathway, and led to increased colony formation in soft agar. Thus, CD74-NRG1 gene fusions are activating genomic alterations in invasive mucinous adenocarcinomas and may offer a therapeutic opportunity for a lung tumor subtype with, so far, no effective treatment. SIGNIFICANCE: CD74-NRG1 fusions may represent a therapeutic opportunity for invasive mucinous lung adenocarcinomas, a tumor with no effective treatment that frequently presents with multifocal unresectable disease. Cancer Discov; 4(4); 415- 22. (c) 2014 AACR.

Published
2014

19. CD74–NRG1 Fusions in Lung Adenocarcinoma

Author

Fernandez-Cuesta, Lynnette, primary, Plenker, Dennis, additional, Osada, Hirotaka, additional, Sun, Ruping, additional, Menon, Roopika, additional, Leenders, Frauke, additional, Ortiz-Cuaran, Sandra, additional, Peifer, Martin, additional, Bos, Marc, additional, Daßler, Juliane, additional, Malchers, Florian, additional, Schöttle, Jakob, additional, Vogel, Wenzel, additional, Dahmen, Ilona, additional, Koker, Mirjam, additional, Ullrich, Roland T., additional, Wright, Gavin M., additional, Russell, Prudence A., additional, Wainer, Zoe, additional, Solomon, Benjamin, additional, Brambilla, Elisabeth, additional, Nagy-Mignotte, Hélène, additional, Moro-Sibilot, Denis, additional, Brambilla, Christian G., additional, Lantuejoul, Sylvie, additional, Altmüller, Janine, additional, Becker, Christian, additional, Nürnberg, Peter, additional, Heuckmann, Johannes M., additional, Stoelben, Erich, additional, Petersen, Iver, additional, Clement, Joachim H., additional, Sänger, Jörg, additional, Muscarella, Lucia A., additional, la Torre, Annamaria, additional, Fazio, Vito M., additional, Lahortiga, Idoya, additional, Perera, Timothy, additional, Ogata, Souichi, additional, Parade, Marc, additional, Brehmer, Dirk, additional, Vingron, Martin, additional, Heukamp, Lukas C., additional, Buettner, Reinhard, additional, Zander, Thomas, additional, Wolf, Jürgen, additional, Perner, Sven, additional, Ansén, Sascha, additional, Haas, Stefan A., additional, Yatabe, Yasushi, additional, and Thomas, Roman K., additional

Published
2014
Full Text
View/download PDF

20. JAK2 Rearrangements, Including the Novel SEC31A-JAK2 Fusion, Are Recurrent in Classical Hodgkin Lymphoma

Author

UCL - Autre, Van Roosbroeck, Katrien, Cox, Luk, Lahortiga, Idoya, Gielen, Olga, Tousseyn, Thomas, Cauwelier, Barbara, De Paepe, Pascale, Vandenberghe, Peter, Marynen, Peter, De Wolf-Peeters, Chris, Cools, Jan, Wlodarska, Iwona, 51st Annual Meeting of the American-Society-of-Hematology, UCL - Autre, Van Roosbroeck, Katrien, Cox, Luk, Lahortiga, Idoya, Gielen, Olga, Tousseyn, Thomas, Cauwelier, Barbara, De Paepe, Pascale, Vandenberghe, Peter, Marynen, Peter, De Wolf-Peeters, Chris, Cools, Jan, Wlodarska, Iwona, and 51st Annual Meeting of the American-Society-of-Hematology

Published
2009

21. Characterization of Nup214-abl1 Positive T-cell Acute Lymphoblastic Leukemia Reveals Genomic Heterogeneity of the Fusion Gene Presentation

Author

UCL - Cliniques universitaires Saint-Luc, UCL - MD/MINT - Département de médecine interne, UCL - MD/BICL - Département de biochimie et de biologie cellulaire, UCL - (MGD) Service d'hématologie, Graux, Carlos, Michaux, Lucienne, Poirel, Hélène, Dastugue, N., Lafage, M., Mugneret, Francine, Struski, S., Gregoire, Michel, Nadal, N., Lippert, E., Stevens-Kroef, M., Vandenberghe, Peter, Bosly, André, Wlodarska, Iwona, Lahortiga, Idoya, De Keersmaecker, Kim, Cools, Jan, Hagemeijer, Anne, UCL - Cliniques universitaires Saint-Luc, UCL - MD/MINT - Département de médecine interne, UCL - MD/BICL - Département de biochimie et de biologie cellulaire, UCL - (MGD) Service d'hématologie, Graux, Carlos, Michaux, Lucienne, Poirel, Hélène, Dastugue, N., Lafage, M., Mugneret, Francine, Struski, S., Gregoire, Michel, Nadal, N., Lippert, E., Stevens-Kroef, M., Vandenberghe, Peter, Bosly, André, Wlodarska, Iwona, Lahortiga, Idoya, De Keersmaecker, Kim, Cools, Jan, and Hagemeijer, Anne

Published
2008

22. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Author

UCL, Lahortiga, Idoya, De Keersmaecker, Kim, Van Vlierberghe, Pieter, Graux, Carlos, Cauwelier, Barbara, Lambert, Frederic, Mentens, Nicole, Beverloo, H. Berna, Pieters, Rob, Speleman, Frank, Odero, Maria D., Bauters, Marijke, Froyen, Guy, Marynen, Peter, Vandenberghe, Peter, Wlodarska, Iwona, Meijerink, Jules P. P., Cools, Jan, UCL, Lahortiga, Idoya, De Keersmaecker, Kim, Van Vlierberghe, Pieter, Graux, Carlos, Cauwelier, Barbara, Lambert, Frederic, Mentens, Nicole, Beverloo, H. Berna, Pieters, Rob, Speleman, Frank, Odero, Maria D., Bauters, Marijke, Froyen, Guy, Marynen, Peter, Vandenberghe, Peter, Wlodarska, Iwona, Meijerink, Jules P. P., and Cools, Jan

Abstract

We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

Published
2007

24. Array-CGH analysis of T-ALL patients and cell lines.

Author

UCL - Autre, Lahortiga, Idoya, Graux, Carlos, Mentens, Nicole, Van Roosbroeck, Katrien, De Keersmaecker, Kim, Lambert, Frederic, Vandenberghe, Peter, Wlodarska, Iwona, Froyen, Guy, Odero, Maria D., Marynen, Peter, Cools, Jan, UCL - Autre, Lahortiga, Idoya, Graux, Carlos, Mentens, Nicole, Van Roosbroeck, Katrien, De Keersmaecker, Kim, Lambert, Frederic, Vandenberghe, Peter, Wlodarska, Iwona, Froyen, Guy, Odero, Maria D., Marynen, Peter, and Cools, Jan

Published
2006

25. Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Author

De Keersmaecker, Kim, primary, Atak, Zeynep Kalender, additional, Li, Ning, additional, Vicente, Carmen, additional, Patchett, Stephanie, additional, Girardi, Tiziana, additional, Gianfelici, Valentina, additional, Geerdens, Ellen, additional, Clappier, Emmanuelle, additional, Porcu, Michaël, additional, Lahortiga, Idoya, additional, Lucà, Rossella, additional, Yan, Jiekun, additional, Hulselmans, Gert, additional, Vranckx, Hilde, additional, Vandepoel, Roel, additional, Sweron, Bram, additional, Jacobs, Kris, additional, Mentens, Nicole, additional, Wlodarska, Iwona, additional, Cauwelier, Barbara, additional, Cloos, Jacqueline, additional, Soulier, Jean, additional, Uyttebroeck, Anne, additional, Bagni, Claudia, additional, Hassan, Bassem A, additional, Vandenberghe, Peter, additional, Johnson, Arlen W, additional, Aerts, Stein, additional, and Cools, Jan, additional

Published
2012
Full Text
View/download PDF

26. High Accuracy Mutation Detection in Leukemia on a Selected Panel of Cancer Genes

Author

Kalender Atak, Zeynep, primary, De Keersmaecker, Kim, additional, Gianfelici, Valentina, additional, Geerdens, Ellen, additional, Vandepoel, Roel, additional, Pauwels, Daphnie, additional, Porcu, Michaël, additional, Lahortiga, Idoya, additional, Brys, Vanessa, additional, Dirks, Willy G., additional, Quentmeier, Hilmar, additional, Cloos, Jacqueline, additional, Cuppens, Harry, additional, Uyttebroeck, Anne, additional, Vandenberghe, Peter, additional, Cools, Jan, additional, and Aerts, Stein, additional

Published
2012
Full Text
View/download PDF

27. JAK2, As Well As PDL1 and PDL2, are Recurrently Targeted by 9p24 Structural and Numerical Aberrations in Lymphoid Neoplasms of Both B- and T-Cell Origin

Author

Van Roosbroeck, Katrien, primary, Tousseyn, Thomas, additional, Ferreiro, Julio Finalet, additional, Lahortiga, Idoya, additional, Michaux, Lucienne, additional, Cauwelier, Barbara, additional, Pienkowska-Grela, Barbara, additional, Verhoef, Gregor, additional, Doyen, Chantal, additional, Theate, Ivan, additional, De Wolf-Peeters, Christiane, additional, Vandenberghe, Peter, additional, and Wlodarska, Iwona, additional

Published
2011
Full Text
View/download PDF

28. Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia

Author

Kleppe, Maria, primary, Lahortiga, Idoya, additional, El Chaar, Tiama, additional, De Keersmaecker, Kim, additional, Mentens, Nicole, additional, Graux, Carlos, additional, Van Roosbroeck, Katrien, additional, Ferrando, Adolfo A, additional, Langerak, Anton W, additional, Meijerink, Jules P P, additional, Sigaux, François, additional, Haferlach, Torsten, additional, Wlodarska, Iwona, additional, Vandenberghe, Peter, additional, Soulier, Jean, additional, and Cools, Jan, additional

Published
2010
Full Text
View/download PDF

29. JAK2 Rearrangements, Including the Novel SEC31A-JAK2 Fusion, Are Recurrent in Classical Hodgkin Lymphoma.

Author

Van Roosbroeck, Katrien, primary, Cox, Luk, additional, Lahortiga, Idoya, additional, Gielen, Olga, additional, Tousseyn, Thomas, additional, Cauwelier, Barbara, additional, De Paepe, Pascale, additional, Vandenberghe, Peter, additional, Marynen, Peter, additional, De Wolf-Peeters, Chris, additional, Cools, Jan, additional, and Wlodarska, Iwona, additional

Published
2009
Full Text
View/download PDF

30. Deletion of the Protein Tyrosine Phosphatase Gene PTPN2 in T-Cell Acute Lymphoblastic Leukemia.

Author

Kleppe, Maria, primary, Lahortiga, Idoya, additional, El Chaar, Tiama, additional, De Keersmaecker, Kim, additional, Mentens, Nicole, additional, Graux, Carlos, additional, Van Roosbroeck, Katrien, additional, Ferrando, Adolfo A., additional, Langerak, Anton W, additional, Meijerink, Jules P.P., additional, Sigaux, Francois, additional, Haferlach, Torsten, additional, Wlodarska, Iwona, additional, Vandenberghe, Peter, additional, Soulier, Jean, additional, and Cools, Jan, additional

Published
2009
Full Text
View/download PDF

33. Simultaneous translocations of FGFR3/MMSET and CCND1 into two different IGH alleles in multiple myeloma: lack of concurrent activation of both proto-oncogenes

Author

Sáez, Borja, primary, Martín-Subero, José I., additional, Lahortiga, Idoya, additional, Largo, Cristina, additional, Larrayoz, María J., additional, Odero, María D., additional, Prosper, Felipe, additional, Cigudosa, Juan C., additional, Siebert, Reiner, additional, and Calasanz, María J., additional

Published
2007
Full Text
View/download PDF

34. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Author

Lahortiga, Idoya, primary, De Keersmaecker, Kim, additional, Van Vlierberghe, Pieter, additional, Graux, Carlos, additional, Cauwelier, Barbara, additional, Lambert, Frederic, additional, Mentens, Nicole, additional, Beverloo, H Berna, additional, Pieters, Rob, additional, Speleman, Frank, additional, Odero, Maria D, additional, Bauters, Marijke, additional, Froyen, Guy, additional, Marynen, Peter, additional, Vandenberghe, Peter, additional, Wlodarska, Iwona, additional, Meijerink, Jules P P, additional, and Cools, Jan, additional

Published
2007
Full Text
View/download PDF

36. Array-CGH Analysis of T-ALL Patients and Cell Lines.

Author

Lahortiga, Idoya, primary, Graux, Carlos, primary, Mentens, Nicole, primary, Van Roosbroeck, Katrien, primary, De Keersmaecker, Kim, primary, Lambert, Frederic, primary, Vandenberghe, Peter, primary, Wlodarska, Iwona, primary, Froyen, Guy, primary, Odero, Maria D., primary, Marynen, Peter, primary, and Cools, Jan, primary

Published
2006
Full Text
View/download PDF

37. GATA2 Is Overexpressed in 46% of Patients with AML and Normal Karyotype. The Mutational Pattern FLT3-ITD/GATA2/WT1 Could Define a Group of Patients with Normal Karyotype and AML-M1 Subtype.

Author

Lahortiga, Idoya, primary, Vazquez, Iria, primary, Marcotegui, Nerea, primary, Bandres, Eva, primary, Malumbres, Raquel, primary, Larrayoz, Maria J., primary, Vicente, Carmen, primary, Cervera, Jose, primary, Hernandez, Jesus M., primary, Garcia-Foncillas, Jesus, primary, Ardanaz, Maria T., primary, Floristan, Filomena, primary, Calasanz, Maria J., primary, and Odero, Maria D., primary

Published
2005
Full Text
View/download PDF

40. Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia

Author

Agirre, Xabier, primary, Román‐Gómez, José, additional, Vázquez, Iria, additional, Jiménez‐Velasco, Antonio, additional, Garate, Leire, additional, Montiel‐Duarte, Cristina, additional, Artieda, Paula, additional, Cordeu, Lucia, additional, Lahortiga, Idoya, additional, Calasanz, María José, additional, Heiniger, Anabel, additional, Torres, Antonio, additional, Minna, John D., additional, and Prósper, Felipe, additional

Published
2005
Full Text
View/download PDF

41. FISH analysis of hematological neoplasias with 1p36 rearrangements allows the definition of a cluster of 2.5�Mb included in the minimal region deleted in 1p36 deletion syndrome

Author

Lahortiga, Idoya, primary, V�zquez, Iria, additional, Belloni, Elena, additional, Rom�n, Jos� P., additional, Gasparini, Patrizia, additional, Novo, Francisco J., additional, Zudaire, Isabel, additional, Pelicci, Pier G., additional, Hern�ndez, Jes�s M., additional, Calasanz, Mar�a J., additional, and Odero, Mar�a D., additional

Published
2005
Full Text
View/download PDF

42. NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2

Author

Lahortiga, Idoya, primary, Belloni, Elena, additional, Vázquez, Iria, additional, Agirre, Xabier, additional, Larrayoz, María J., additional, Vizmanos, Jose L., additional, Valgañón, Mikel, additional, Zudaire, Isabel, additional, Sáez, Borja, additional, Mateos, María C., additional, Di Fiore, Pier Paolo, additional, Calasanz, María J., additional, and Odero, María D., additional

Published
2005
Full Text
View/download PDF

44. NIN , a Gene Encoding a CEP110-Like Centrosomal Protein, Is Fused toPDGFRBin a Patient with a t(5;14)(q33;q24) and an Imatinib-Responsive Myeloproliferative Disorder

Author

Vizmanos, José L., primary, Novo, Francisco J., additional, Román, José P., additional, Baxter, E. Joanna, additional, Lahortiga, Idoya, additional, Larráyoz, María J., additional, Odero, María D., additional, Giraldo, Pilar, additional, Calasanz, María J., additional, and Cross, Nicholas C. P., additional

Published
2004
Full Text
View/download PDF

45. A new complex rearrangement involving theETV6,LOC115548, andMN1 genes in a case of acute myeloid leukemia

Author

Belloni, Elena, primary, Trubia, Maurizio, additional, Mancini, Marco, additional, Derme, Valentina, additional, Nanni, Mauro, additional, Lahortiga, Idoya, additional, Riccioni, Roberta, additional, Confalonieri, Stefano, additional, Lo-Coco, Francesco, additional, Di Fiore, Pier Paolo, additional, and Pelicci, Pier Giuseppe, additional

Published
2004
Full Text
View/download PDF

50. Insertion (22;9)(q11;q34q21) in a patient with chronic myeloid leukemia characterized by fluorescence in situ hybridization

Author

Martı́n-Subero, José I, primary, Lahortiga, Idoya, additional, Gómez, Emilio, additional, Ferreira, Carmen, additional, Larrayoz, Marı́a José, additional, Odero, Marı́a Dolores, additional, Garcı́a-Delgado, Marina, additional, Novo, Francisco Javier, additional, Giraldo, Pilar, additional, and Calasanz, Marı́a José, additional

Published
2001
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results