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4. Thromboelastogram changes are associated with postoperative complications after cytoreductive surgery

Author

Goder Noam, Zac Lilach, Nevo Nadav, Gerstenhaber Fabian, Goren Or, Cohen Barak, Matot Idit, Lahat Guy, and Nizri Eran

Subjects
thromboelastogram, hyperthermic intraperitoneal chemotherapy, postoperative complications, Medicine, Specialties of internal medicine, RC581-951
Abstract

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is used to treat peritoneal surface malignancies. However, surgical morbidity is high, and prediction of severe postoperative complications (SPC) is limited. We hypothesized that the changes in thromboelastogram (TEG) values following CRS could be associated with SPC.

Published
2024
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24. Predictors of Poor Quality of Life in Patients with Gastroesophageal Reflux Disease Undergoing Sleeve Gastrectomy.

Author

Yuval, Jonathan B., Kanani, Fahim, Keidar, Andrei, Eldar, Shai Meron, Nizri, Eran, Lahat, Guy, and Abu-Abeid, Adam

Subjects
SLEEVE gastrectomy, SMOKING cessation, DATABASES, UNIVERSITY hospitals, QUALITY of life
Abstract

Background—Gastroesophageal reflux disease (GERD) is commonly diagnosed in patients with severe obesity. The outcomes of patients with preoperative GERD after sleeve gastrectomy (SG) are unclear, and some surgeons consider GERD a contraindication for SG. Methods—A retrospective analysis of a tertiary university hospital database was conducted. All patients with preoperative GERD undergoing SG between January 2012 and January 2020 and having at least two years of follow-up were included in the analysis. A validated GERD-associated quality of life questionnaire (GERD-HRQL) was completed by all patients. Results—During the study period, 116/1985 patients (5.8%) were diagnosed with GERD before SG. In total, 55 patients were available for a two-year follow-up and were included in the analysis. Median follow-up was 40 months (range 24–156 months). Mean total weight loss (TWL) was 24.0% ± 12.0%. On follow-up, 43 patients (78.1%) reported having GERD symptoms. In patients who underwent postoperative endoscopy, less than a third had esophagitis. The mean GERD-HRQL score was 25.2 ± 10.9. On univariable analysis, patients with poor GERD-HRQL had lower BMI at baseline (41.5 ± 12.4 vs. 44.9 ± 10.0 kg/m2, p = 0.03), were less commonly smokers at baseline (8.1% vs. 33.3%, p = 0.02), and had lower TWL at the end of the follow-up (22.2% ± 10.4% vs. 28.9% ± 13.7%, p = 0.05). On multivariable analysis, smoking status at baseline and TWL at last follow-up were independent predictors of better GERD-HRQL. Conclusions—In conclusion, most GERD patients after SG have a relatively high GERD-HRQL score, most patients still have GERD symptoms during the follow-up, and approximately a third of patients have endoscopic signs of esophagitis. There was an association between patients with higher TWL and smoking at baseline and better GERD-HRQL outcomes. The latter is potentially due to smoking cessation. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer

Author

Gavert, Nancy, Zwang, Yaara, Weiser, Roi, Greenberg, Orli, Halperin, Sharon, Jacobi, Oded, Mallel, Giuseppe, Sandler, Oded, Berger, Adi Jacob, Stossel, Erez, Rotin, Daniil, Grinshpun, Albert, Kamer, Iris, Bar, Jair, Pines, Guy, Saidian, Daniel, Bar, Ilan, Golan, Shay, Rosenbaum, Eli, Nadu, Andrei, Ben-Ami, Eytan, Weitzen, Rony, Nechushtan, Hovav, Golan, Talia, Brenner, Baruch, Nissan, Aviram, Margalit, Ofer, Hershkovitz, Dov, Lahat, Guy, and Straussman, Ravid

Published
2022
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28. Analysis of Differentiation Changes and Outcomes at Time of First Recurrence of Retroperitoneal Liposarcoma by Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Blay, Jean-Yves, Strauss, Dirk, Rutkowski, Piotr, Ahuja, Nita, Gonzalez, Ricardo, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, Lahat, Guy, De Paoli, Antonino, Pillarisetty, Venu G., Canter, Robert J., Mullen, John T., Pennacchioli, Elisabetta, van Houdt, Winan, Swallow, Carol J., Schrage, Yvonne, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Bagaria, Sanjay P.

Published
2021
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30. Postoperative Morbidity After Resection of Recurrent Retroperitoneal Sarcoma: A Report from the Transatlantic Australasian RPS Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Rutkowski, Piotr, Blay, Jean-Yves, Strauss, Dirk, Gonzalez, Ricardo, Ahuja, Nita, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, De Paoli, Antonino, Pillarisetty, Venu G., Swallow, Carol J., Bagaria, Sanjay P., Canter, Robert J., Mullen, John T., Schrage, Yvonne, Pennacchioli, Elisabetta, van Houdt, Winan, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Lahat, Guy

Published
2021
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32. Primary Versus Revisional Bariatric and Metabolic Surgery in Patients with a Body Mass Index ≥ 50 kg/m2—90-Day Outcomes and Risk of Perioperative Mortality.

Author

Abu-Abeid, Adam, Dvir, Nadav, Lessing, Yonatan, Eldar, Shai Meron, Lahat, Guy, Keidar, Andrei, and Yuval, Jonathan Benjamin

Abstract

Background: Bariatric and metabolic surgery (BMS) is an effective treatment for patients with severe obesity. Patients with higher body mass index (BMI) and patients undergoing revisional surgery have a higher rate of major complications. This study purpose is to evaluate perioperative outcomes of patients with BMI ≥ 50 kg/m2. Materials and Methods: A retrospective analysis of patients with a BMI ≥ 50 kg/m2 undergoing BMS between 2015 and 2023 was conducted. A comparative analysis was performed between patients undergoing primary versus revisional surgery. Results: A total of 263 patients were included in the study. Primary procedures were performed in 220 patients (83.7%) and revisional procedures in 43 patients (16.3%). BMS included one anastomosis gastric bypass (n = 183), sleeve gastrectomy (n = 63), and other procedures (n = 17). Mean BMI was 54.6 with no difference between groups. There was no difference in baseline characteristics except the revisional group was older (44.8 ± 9.6 versus 39 ± 13 years; p = 0.006), had higher rates of gastroesophageal reflux disease (21% vs 7.3%; p = 0.005), and fatty liver disease (74% vs 55%; p = 0.02). There was perioperative mortality in three cases (1.1%) with no significant difference between groups. Leak rates were higher, and length of stay (LOS) was longer in the revisional group (4.6% vs 0.45%; p = 0.018 and 2.9 vs 3.7; p = 0.006, respectively). Conclusion: Revisional BMS in patients with a BMI ≥ 50 kg/m2 is associated with increased leak rates and LOS. Mortality rate is 1.1% and is insignificantly different between groups. Further prospective and large-scale studies are needed to clarify the optimal surgical approach to patients with extreme BMI including revisional surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Correction to: Postoperative Morbidity After Resection of Recurrent Retroperitoneal Sarcoma: A Report from the Transatlantic Australasian RPS Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Rutkowski, Piotr, Blay, Jean-Yves, Strauss, Dirk, Gonzalez, Ricardo, Ahuja, Nita, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, De Paoli, Antonino, Pillarisetty, Venu G., Swallow, Carol J., Bagaria, Sanjay P., Canter, Robert J., Mullen, John T., Schrage, Yvonne, Pennacchioli, Elisabetta, van Houdt, Winan, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Lahat, Guy

Published
2022
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37. Correction: ASO Visual Abstract: An Analysis of Differentiation Changes and Outcomes at the First Recurrence of Retroperitoneal Liposarcoma by the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Blay, Jean-Yves, Strauss, Dirk, Rutkowski, Piotr, Ahuja, Nita, Gonzalez, Ricardo, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, Lahat, Guy, De Paoli, Antonino, Pillarisetty, Venu G., Canter, Robert J., Mullen, John T., Pennacchioli, Elisabetta, van Houdt, Winan, Swallow, Carol J., Schrage, Yvonne, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Bagaria, Sanjay P.

Published
2022
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38. Correction to: Analysis of Differentiation Changes and Outcomes at Time of First Recurrence of Retroperitoneal Liposarcoma by Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Blay, Jean-Yves, Strauss, Dirk, Rutkowski, Piotr, Ahuja, Nita, Gonzalez, Ricardo, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, Lahat, Guy, De Paoli, Antonino, Pillarisetty, Venu G., Canter, Robert J., Mullen, John T., Pennacchioli, Elisabetta, van Houdt, Winan, Swallow, Carol J., Schrage, Yvonne, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Bagaria, Sanjay P.

Published
2022
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39. ASO Visual Abstract: An Analysis of Differentiation Changes and Outcomes at the First Recurrence of Retroperitoneal Liposarcoma by the Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG)

Author

Nessim, Carolyn, Raut, Chandrajit P., Callegaro, Dario, Barretta, Francesco, Miceli, Rosalba, Fairweather, Mark, Blay, Jean-Yves, Strauss, Dirk, Rutkowski, Piotr, Ahuja, Nita, Gonzalez, Ricardo, Grignani, Giovanni, Quagliuolo, Vittorio, Stoeckle, Eberhard, Lahat, Guy, De Paoli, Antonino, Pillarisetty, Venu G., Canter, Robert J., Mullen, John T., Pennacchioli, Elisabetta, van Houdt, Winan, Swallow, Carol J., Schrage, Yvonne, Cardona, Kenneth, Fiore, Marco, Gronchi, Alessandro, and Bagaria, Sanjay P.

Published
2021
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41. Primary versus Revisional One Anastomosis Gastric Bypass: Outcomes of Patients with at Least 8-Year Follow-Up.

Author

Abu-Abeid, Adam, Bendayan, Anat, Yuval, Jonathan B., Eldar, Shai Meron, Lahat, Guy, and Lessing, Yonatan

Subjects
GASTRIC bypass, SURGICAL anastomosis, WEIGHT loss, TYPE 2 diabetes, MEDICAL registries, DISEASE complications
Abstract

Introduction: One anastomosis gastric bypass (OAGB) prevalence is increasing worldwide and shows good mid- to long-term results. Data on long-term outcomes of revisional OAGB (rOAGB) is limited. This study's objective was to evaluate the long-term outcomes of patients undergoing primary OAGB (pOAGB) and rOAGB. Methods: A retrospective analysis of a prospectively maintained patient registry at a single-tertiary center. Patients undergoing OAGB from January 2015 to May 2016 were included and grouped into pOAGB and rOAGB. Results: There were 424 patients, of which 363 underwent pOAGB, and 61 underwent rOAGB. Baseline characteristics were insignificantly different between groups except for the type 2 diabetes (T2D) rate which was higher in pOAGB (26% vs. 11.5%, p = 0.01). The mean follow-up time was 98.5 ± 3.9 months, and long-term follow-up data were available for 52.5% of patients. The mean total weight loss (TWL) was higher in the pOAGB group (31.3 ± 14 vs. 24.1 ± 17.6, p = 0.006); however, TWL was comparable when relating to the weight at primary surgery for rOAGB. The rate of T2D and hypertension resolution was 79% and 72.7% with no difference between groups. Thirteen patients (5.9%) underwent OAGB revision during follow-up, with no difference between groups. Two deaths occurred during follow-up, both non-related to OAGB. Conclusion: OAGB is effective as a primary and as a revisional procedure for severe obesity with good long-term results in terms of weight loss and resolution of associated diseases. In addition, the revisional surgery rates and chronic complications are acceptable. Further large prospective studies are required to clarify these data. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Treatment of Peritoneal Surface Malignancies with Cytoreductive Surgery and Hyperthermic Intra-peritoneal Chemotherapy (HIPEC): Experience in Israel

Author

Ben-Yaacov, Almog, Nizri, Eran, Lahat, Guy, Berger, Yaniv, Sadot, Eran, Lavi, Ron, Zippel, Dov, Sebbag, Gilbert, Avital, Itzhak, Hoffman, Aviad, Gutman, Mordechai, Halevy, Ariel, Schneibaum, Shlomo, Ben-Ari, Gur, Benchimol, Daniel, Klausner, Joseph, Nissan, Aviram, and For the Israeli Peritoneal Oncology Research Group

Published
2019
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46. Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma.

Author

Mito, Jeffrey K, Riedel, Richard F, Dodd, Leslie, Lahat, Guy, Lazar, Alexander J, Dodd, Rebecca D, Stangenberg, Lars, Eward, William C, Hornicek, Francis J, Yoon, Sam S, Brigman, Brian E, Jacks, Tyler, Lev, Dina, Mukherjee, Sayan, and Kirsch, David G

Subjects
Animals, Humans, Mice, Sarcoma, Soft Tissue Neoplasms, Neoplasm Metastasis, Disease Models, Animal, Microarray Analysis, Gene Expression Profiling, Genomics, Species Specificity, Genotype, Genes, p53, Genome, Histiocytoma, Malignant Fibrous, Disease Models, Animal, Genes, p53, Histiocytoma, Malignant Fibrous, General Science & Technology
Abstract

Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras(G12D); Trp53(Flox/Flox) mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of Foxm1 is elevated in mouse sarcomas that metastasize to the lung and tissue microarray analysis of human MFH correlates overexpression of FOXM1 with metastasis. These results suggest that genomic alterations present in human MFH are conserved in the LSL-Kras(G12D); p53(Flox/Flox) mouse model of soft tissue sarcoma and demonstrate the utility of this pre-clinical model.

Published
2009

50. Supplementary Figure 1B from Predicting Survival in Patients Undergoing Resection for Locally Recurrent Retroperitoneal Sarcoma: A Study and Novel Nomogram from TARPSWG

Author

Raut, Chandrajit P., primary, Callegaro, Dario, primary, Miceli, Rosalba, primary, Barretta, Francesco, primary, Rutkowski, Piotr, primary, Blay, Jean-Yves, primary, Lahat, Guy, primary, Strauss, Dirk C., primary, Gonzalez, Ricardo, primary, Ahuja, Nita, primary, Grignani, Giovanni, primary, Quagliuolo, Vittorio, primary, Stoeckle, Eberhard, primary, De Paoli, Antonino, primary, Pillarisetty, Venu G., primary, Nessim, Carolyn, primary, Swallow, Carol J., primary, Bagaria, Sanjay, primary, Canter, Robert, primary, Mullen, John, primary, Gelderblom, Hans J., primary, Pennacchioli, Elisabetta, primary, van Coevorden, Frits, primary, Cardona, Kenneth, primary, Fiore, Marco, primary, Fairweather, Mark, primary, and Gronchi, Alessandro, primary

Published
2023
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