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9 results on '"Lago, Alexsandro S."'

1. Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity

Author

Farias Amorim, Camila, primary, Lovins, Victoria M., additional, Singh, Tej Pratap, additional, Novais, Fernanda O., additional, Harris, Jordan C., additional, Lago, Alexsandro S., additional, Carvalho, Lucas P., additional, Carvalho, Edgar M., additional, Beiting, Daniel P., additional, Scott, Phillip, additional, and Grice, Elizabeth A., additional

Published
2023
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2. Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies

Author

Pilling, Olivia A., primary, Reis-Cunha, João L., additional, Grace, Cooper A., additional, Berry, Alexander S. F., additional, Mitchell, Matthew W., additional, Yu, Jane A., additional, Malekshahi, Clara R., additional, Krespan, Elise, additional, Go, Christina K., additional, Lombana, Cláudia, additional, Song, Yun S., additional, Amorim, Camila F., additional, Lago, Alexsandro S., additional, Carvalho, Lucas P., additional, Carvalho, Edgar M., additional, Brisson, Dustin, additional, Scott, Phillip, additional, Jeffares, Daniel C., additional, and Beiting, Daniel P., additional

Published
2023
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3. The skin microbiome enhances disease through IL-1b and delays healing in cutaneous leishmaniasis patients

Author

Farias Amorim, Camila, primary, Lovins, Victoria M., additional, Singh, Tej Pratap, additional, Novais, Fernanda O., additional, Harris, Jordan C., additional, Lago, Alexsandro S., additional, Carvalho, Lucas P., additional, Carvalho, Edgar M., additional, Beiting, Daniel P., additional, Scott, Phillip, additional, and Grice, Elizabeth A., additional

Published
2023
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4. Selective whole-genome amplification reveals population genetics of Leishmania braziliensis directly from patient skin biopsies

Author

Pilling, Olivia A., primary, Reis-Cunha, Joao L, additional, Grace, Cooper A, additional, Berry, Alexander SF, additional, Mitchell, Matthew W, additional, Yu, Jane A, additional, Malekshahi, Clara, additional, Krespan, Elise, additional, Go, Christina K, additional, Lombana, Claudia, additional, Song, Yun S, additional, Amorim, Camila F, additional, Lago, Alexsandro S, additional, Carvalho, Lucas P, additional, Carvalho, Edgar M, additional, Brisson, Dustin, additional, Scott, Phillip, additional, Jeffares, Daniel C, additional, and Beiting, Daniel P., additional

Published
2022
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7. Diabetes Modifies the Clinic Presentation of Cutaneous Leishmaniasis

Author

Lago, Alexsandro S, primary, Lima, Filipe R, additional, Carvalho, Augusto M, additional, Sampaio, Camilla, additional, Lago, Neuza, additional, Guimarães, Luiz H, additional, Lago, Jamile, additional, Machado, Paulo R L, additional, Carvalho, Lucas P, additional, Arruda, Sérgio, additional, and Carvalho, Edgar M, additional

Published
2020
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9. The skin microbiome enhances disease through IL-1b and delays healing in cutaneous leishmaniasis patients.

Author

Farias Amorim C, Lovins VM, Singh TP, Novais FO, Harris JC, Lago AS, Carvalho LP, Carvalho EM, Beiting DP, Scott P, and Grice EA

Abstract

Leishmania braziliensis infection results in inflammation and skin injury, with highly variable and unpredictable clinical outcomes. Here, we investigated the potential impact of microbiota on infection-induced inflammatory responses and disease resolution by conducting an integrated analysis of the skin microbiome and host transcriptome on a cohort of 62 L. braziliensis -infected patients. We found that overall bacterial burden and microbiome configurations dominated with Staphylococcus spp. were associated with delayed healing and enhanced inflammatory responses, especially by IL-1 family members. Dual RNA-seq of human lesions revealed that high lesional S. aureus transcript abundance was associated with delayed healing and increased expression of IL-1β. This cytokine was critical for modulating disease outcome in L. braziliensis -infected mice colonized with S. aureus , as its neutralization reduced pathology and inflammation. These results implicate the microbiome in cutaneous leishmaniasis disease outcomes in humans and suggest host-directed therapies to mitigate the inflammatory consequences.

Published
2023
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