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2. Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

Author

Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, Rivera, José M., Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., and Suárez Fernández, C.

Published
2018
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3. Factores asociados al mal control de la anticoagulación con antivitamina K en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author

Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, Rivera., José M., Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., and Suárez Fernández, C.

Published
2018
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4. MRI predicts intracranial hemorrhage in patients who receive long-term oral anticoagulation

Author

Martí-Fàbregas, Joan, Medrano-Martorell, Santiago, Merino, Elisa, Prats-Sánchez, Luis, Marín, Rebeca, Delgado-Mederos, Raquel, Martínez-Domeño, Alejandro, Camps-Renom, Pol, Jiménez-Xarrié, Elena, Zedde, Mariluisa, Gómez-Choco, Manuel, Lara, Lidia, Boix, Amèlia, Calleja, Ana, De Arce-Borda, Ana María, Bravo, Yolanda, Fuentes, Blanca, Hernández-Pérez, María, Cánovas, David, Llull, Laura, Zandio, Beatriz, Freijo, Marimar, Casado-Naranjo, Ignacio, Sanahuja, Jordi, Cocho, Dolores, Krupinski, Jerzy, Rodríguez-Campello, Ana, Palomeras, Ernest, De Felipe, Alicia, Serrano, Marta, Zapata-Arriaza, Elena, Zaragoza-Brunet, Josep, Díaz-Maroto, Inmaculada, Fernández-Domínguez, Jessica, Lago, Aida, Maestre, José, Rodríguez-Yáñez, Manuel, and Gich, Ignasi

Published
2019
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11. Infartos cerebrales intrahospitalarios: datos del registro multicéntrico de pacientes con infarto cerebral ingresados en Cardiología y Cirugía Cardiaca

Author

Vera, Rocío, Lago, Aída, Fuentes, Blanca, Gállego, Jaime, Tejada, Javier, Casado, Ignacio, Purroy, Francisco, Delgado, Pilar, Simal, Patricia, Martí-Fábregas, Joan, Vivancos, José, Díaz-Otero, Fernando, Freijo, Mar, Díez-Tejedor, Exuperio, Gil-Núñez, Antonio, Egido, Jose, Reig, Gemma, Calle, María Luisa, de Leciñana, María Alonso, and Masjuan, Jaime

Published
2011
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13. Combination of Thrombolysis and Statins in Acute Stroke Is Safe: Results of the STARS Randomized Trial (Stroke Treatment With Acute Reperfusion and Simvastatin)

Author

Montaner, Joan, Bustamante, Alejandro, García-Matas, Silvia, Martínez-Zabaleta, Maite, Jiménez, Carmen, de la Torre, Javier, Rubio, Francisco R., Segura, Tomás, Masjuán, Jaime, Cánovas, David, Freijo, Mar, Delgado-Mederos, Raquel, Tejada, Javier, Lago, Aida, Bravo, Yolanda, Corbeto, Natália, Giralt, Dolors, Vives-Pastor, Bárbara, de Arce, Anna, Moniche, Francisco, Delgado, Pilar, and Ribó, Marc

Published
2016
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16. Time Trends in Intracerebral Hemorrhage Associated with Oral Anticoagulation and Its Risks Factors in Spain from 2008 to 2015

Author

Quintas, Sonia, primary, Zapata-Wainberg, Gustavo, additional, Arias-Rivas, Susana, additional, Ximénez-Carrillo, Álvaro, additional, Castillo, Jose, additional, Benavente Fernández, Lorena, additional, Masjuan Vallejo, Jaime, additional, Freijó Guerrero, María del Mar, additional, Egido, José, additional, García Pastor, Andrés, additional, Cardona, Pere, additional, Lago, Aida, additional, Castellanos Rodrigo, Mar, additional, Fuentes, Blanca, additional, Sobrado, Mónica, additional, and Vivancos, Jose, additional

Published
2020
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17. Progression of carotid near-occlusion to complete occlusion: related factors and clinical implications

Author

García-Pastor, Andrés, primary, Gil-Núñez, Antonio, additional, Ramírez-Moreno, José María, additional, González-Nafría, Noelia, additional, Tejada, Javier, additional, Moniche, Francisco, additional, Portilla-Cuenca, Juan Carlos, additional, Martínez-Sánchez, Patricia, additional, Fuentes, Blanca, additional, Gamero-García, Miguel Ángel, additional, Alonso de Leciñana, María, additional, Masjuan, Jaime, additional, Cánovas, David, additional, Aladro, Yolanda, additional, Parkhutik, Vera, additional, Lago, Aida, additional, De Arce, Ana María, additional, Usero-Ruiz, María, additional, Delgado-Mederos, Raquel, additional, Pampliega, Ana, additional, Ximénez-Carrillo, Álvaro, additional, Bártulos-Iglesias, Mónica, additional, and Castro-Reyes, Enrique, additional

Published
2020
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23. Association of High Serum Levels of Growth Factors with Good Outcome in Ischemic Stroke : a Multicenter Study

Author

Sobrino, Tomás, Rodríguez-Yáñez, Manuel, Campos, Francisco, Iglesias-Rey, Ramón, Millán, Mónica, de la Ossa Pérez, Natàlia, Dávalos, Antoni, Delgado Mederos, Raquel, Martínez-Domeño, Alejandro, Martí-Fábregas, Joan, Castellanos, Mar, Serena, Joaquín, Lago, Aida, Díez-Tejedor, Exuperio, Castillo, José, Universitat Autònoma de Barcelona, UAM. Departamento de Medicina, and Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Neurology, Medicina, Gastroenterology, Lesion, 03 medical and health sciences, 0302 clinical medicine, Modified Rankin Scale, Internal medicine, medicine, Humans, Prospective Studies, Good outcome, Stroke, Aged, Ischemic stroke, business.industry, General Neuroscience, High serum, Middle Aged, medicine.disease, Prognosis, Chemokine CXCL12, 030104 developmental biology, Infarct volume, Multicenter study, Intercellular Signaling Peptides and Proteins, Original Article, Female, Neurology (clinical), medicine.symptom, Cardiology and Cardiovascular Medicine, business, Growth factors, 030217 neurology & neurosurgery, Growth factors, Infarct volume, Ischemic stroke, Prognosis
Abstract

Themain objective of this researchwork was to study the association of serumlevels of growth factors (GF) and SDF-1α with the functional outcome and reduction of lesion volume in ischemic stroke patients. In this multicenter study, 552 patients with nonlacunar stroke (male, 62.1%; mean age, 68.2 ± 11.4) were included within 24 h from symptom onset. The main outcome variable was good functional outcome (modified Rankin Scale [mRS] ≤ 2) at 12 months. Secondary outcome variable was infarct volume (inmL) after 6 ± 3 months. Serum levels of VEGF, Ang-1,G-CSF, BDNF, and SDF-1α were measured by ELISA at admission, 7 ± 1 days, at 3 ± 1 months, and 12 ± 3 months. Except for BDNF, all GF and SDF-1α serum levels showed a peak value at day 7 and remained elevated during the first 3 months (all p < 0.01).High serumlevels at day 7 ofVEGF (OR, 19.3),Ang-1 (OR, 14.7), G-CSF (OR, 9.6), and SDF-1α (OR, 28.5) were independently associated with good outcome at 12 months (all p < 0.0001).On the other hand, serum levels of VEGF (B, − 21.4), G-CSF (B, − 14.0), Ang-1 (B, − 13.3), and SDF-1α (B, − 44.6) measured at day 7 were independently associated with lesion volume at 6 months (p < 0.01). In summary, high serum levels of VEGF, Ang-1, G-CSF, and SDF-1α at day 7 and 3 months after ischemic stroke are associated with good functional outcome and smallerresidual lesion at 1 year of follow-up., This project was partially supported by grants from the Spanish Ministry of Economy and Competitiveness (SAF2014-56336-R; RTI2018-102165-B-I00 and SAF2017-84267-R), Xunta de Galicia (Consellería Educación: GRC2014/027 and IN607A2018/3), Instituto de Salud Carlos III (PI13/00292, PI14/01879 and PI17/01103), Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS PLUS (RD16/0019), and by the European Union FEDER program. T. Sobrino (CP12/03121 &CPII17/00027) and F. Campos (CP14/00154 & CPII19/ 00020) are recipients of research contracts from Miguel Servet Program of Instituto de Salud Carlos III.

Published
2019

27. Time Trends in Intracerebral Hemorrhage Associated with Oral Anticoagulation and Its Risks Factors in Spain from 2008 to 2015.

Author

Quintas, Sonia, Zapata-Wainberg, Gustavo, Arias-Rivas, Susana, Ximénez-Carrillo, Álvaro, Castillo, Jose, Benavente Fernández, Lorena, Masjuan Vallejo, Jaime, Freijó Guerrero, María del Mar, Egido, José, García Pastor, Andrés, Cardona, Pere, Lago, Aida, Castellanos Rodrigo, Mar, Fuentes, Blanca, Sobrado, Mónica, and Vivancos, Jose

Subjects
CEREBRAL hemorrhage, ANTICOAGULANTS, DYSLIPIDEMIA, POPULATION aging, DATA analysis
Abstract

Background: Intracerebral hemorrhage (ICH) is 7- to 10-fold higher in anticoagulated patients. Given the more extended use of oral anticoagulants, an increase in the prevalence of ICH associated with oral anticoagulation (ICH-OAC) could be expected. However, there is no previous study that assesses the time trends of ICH-OAC in Spain. Methods: We conducted a combined data analysis after creating a joint database of the 3 most important epidemiological studies on ICH-OAC of our country: the EPICES study (2008–2009), the TAC Registry (TR) study (2012–2013) and the TAC Registry 2 (TR2) study (2015). We finally included 65, 235, and 366 patients from the EPICES, TR, and TR2 studies, respectively. Results: We have observed a 3.73-fold increase in the crude annual incidence of ICH-OAC throughout the period of study, with proportion of ICH-OAC out of total ICH increasing from 8.4% in 2008 to 18.2% in 2015. Age, dyslipidemia, and prior antiplatelet treatment increased during the study, but we found no statistically significant differences in other risk factors for ICH-OAC. Conclusions: The incidence of ICH-OAC is increasing in our country. It might at least be partly explained by aging of the population, with mean age at presentation being higher in the last years. [ABSTRACT FROM AUTHOR]

Published
2021
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28. Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

Author

Contreras Muruaga, M.M., primary, Reig, G., additional, Vivancos, J., additional, González, A., additional, Cardona, P., additional, Ramírez-Moreno, J.M., additional, Martí-Fábregas, J., additional, Suárez Fernández, C., additional, Pose, Antonio, additional, Díaz, José Antonio, additional, Rodríguez, Manuel, additional, Pena, Marta, additional, Arias, Susana, additional, Larrosa, Davinia, additional, González, Álvaro, additional, Rodríguez, Elisa, additional, González, Montserrat, additional, Fernández, Dolores, additional, Barbagelata, Cristina, additional, Raña, Natividad, additional, Freire, Santiago, additional, Cerqueiro, J. Manuel, additional, Guerrero, Héctor, additional, Ramos, Laura, additional, Álvarez, Leticia, additional, de Lis, José M., additional, Caro, Carmen, additional, Seijo, Manuel, additional, Mederer, Susana, additional, de Zarraga, Miguel Alberto, additional, Ferreiro, José, additional, Terrero, José M., additional, Arias, Mónica, additional, Pérez, Roberto, additional, Sánchez, Joaquín, additional, Maciñeiras, José, additional, Fernández, Julián, additional, Jaén, Fernando, additional, Esteva, David, additional, Zamora, Mónica, additional, Navarrete, Nuria, additional, García, Javier, additional, Mérida, Luis, additional, Corrales, Miguel Ángel, additional, Quirós, Raúl, additional, Cantero, Jesús, additional, Barrero, Francisco Javier, additional, Villegas, Inmaculada, additional, Castro, José, additional, Foronda, Jesús, additional, Carrillo, Dionisio, additional, Vega, Jesús, additional, Trujillo, José Antonio, additional, Montero, Manuel, additional, Jurado, Ana, additional, Sánchez, Carlos, additional, Agüera-Morales, Eduardo, additional, Sánchez, María, additional, Durán, Purificación, additional, Fernández de la Puerta, Rafael, additional, Pérez de la Blanca, María, additional, Martínez, María Paz, additional, Fernández, Óscar, additional, Tamayo, José Antonio, additional, Bustamante, Rafael, additional, Serrano, Pedro Jesús, additional, Arjona, Antonio, additional, Fernández, Javier, additional, Payan, Manuel, additional, Gómez, Ricardo, additional, Peña, Daniel, additional, Cabrerizo, Enrique, additional, Salgado, Fernando, additional, Ivanova Georgieva, Radka, additional, Gil-Núñez, Antonio, additional, Bello, Elena, additional, Díaz, Fernando, additional, Medina, Antonio, additional, Castellano, Ana, additional, Miranda, Yesica, additional, Fabre, Óscar, additional, García Polo, Iluminada, additional, Ibáñez, Patricia, additional, Sainz, Clara, additional, Sierra, Fernando, additional, Aragón, Esther, additional, Díaz, Jaime, additional, Aguilar, Fernando, additional, Ortega, María Ángeles, additional, Egido, José Antonio, additional, Pontes, José Carlos, additional, García, Miguel Ángel, additional, Cabrera, Francisco, additional, Batalla, Blanca, additional, Culla, Alex, additional, Molina, Carlos, additional, Flores, Alan, additional, Seró, Laia, additional, Muchada, Marian, additional, Meler, Pilar, additional, Boned-Riera, Sandra, additional, Cánovas, David, additional, Estela, Jordi, additional, Font, Juli, additional, Purroy, Francisco, additional, Benabdelhak, Ikram, additional, Sanahuja, Jordi, additional, Roquer, Jaume, additional, Rodríguez, Ana, additional, Ois, Ángel, additional, Cuadrado, Elisa, additional, Jiménez, Jordi, additional, Nogués, Xavier, additional, Kuprinski, Jerzy, additional, German, Antoni, additional, Irigoyen, Daniel, additional, Cara, Juan José, additional, Font, Maria Àngels, additional, Huertas, Sonia, additional, Martínez-Domeño, Alejandro, additional, Arroyo, Juan Antonio, additional, Delgado-Mederos, Raquel, additional, Gómez-Choco, Manuel Jesús, additional, Mengual, Juan José, additional, García, Sonia M., additional, Castellanos, M. del Mar, additional, van Eedenburg, Cecile, additional, Cañas, Imma, additional, Espinosa, Jordi, additional, Montull, Santiago, additional, Quesada, Helena, additional, Ustrell, Xavier, additional, Homedes, Christian, additional, Navalpotro, Irene, additional, Casanova, Jordi, additional, Lago, Aida Pilar, additional, Morata, Carmen, additional, Gorriz, David, additional, Moreno, Iván, additional, Tembl, José, additional, Ponz, Alejandro, additional, Fonseca, M. José, additional, Chamarro, Raquel, additional, Gil, Rosario, additional, Oliver, Vicente, additional, Pampliega, Ana, additional, Artero, Arturo, additional, Puchades, Francesc, additional, Landete, Lamberto, additional, Vilar, Carlos, additional, Jiménez, Carmen, additional, Vives, Bárbara, additional, Moragues, M. Dolores, additional, Díaz, Rosa, additional, Tur, Silvia, additional, Escribano, José Bernardo, additional, Lucas, César, additional, Martínez, Francisco, additional, Pons, José Miguel, additional, Romero, Amparo, additional, García, David, additional, Pérez, José, additional, Villaverde, Ramón, additional, Martínez, Salvadora, additional, Rodríguez, Aida, additional, Tejero, Carlos, additional, Pérez, Cristina, additional, Mostacero, Enrique, additional, Fernández, Covadonga, additional, Luna, Alain, additional, Pérez, Tomás, additional, González, Félix, additional, de Arce, Ana, additional, Martínez, Maite, additional, Díez, Noemí, additional, Gállego, Jaime, additional, Zandio, Beatriz, additional, Herrera, María, additional, Aymerich, Nuria, additional, Muñoz, Roberto, additional, Marta, Javier, additional, Artal, Jorge, additional, Errea, José M., additional, Timiraos, Juan José, additional, Moreno, M. Pilar, additional, Freijo, Mar, additional, García, Juan Manuel, additional, Gil, M. Carmen, additional, Revilla, M. Ángeles, additional, Palacio, Enrique, additional, Vázquez, José Luis, additional, Bestué, María, additional, Latorre, Ana, additional, Calvo, Eva, additional, Ballester, Laura, additional, Serrano, Marta, additional, Juega, Jesús M., additional, López, M. Ángeles, additional, Irimia, Pablo, additional, Imaz, Laura, additional, Fuentes, Blanca, additional, Sanz, Borja Enrique, additional, Beltrán, Luis, additional, Ruiz, Gerardo, additional, Martínez, Patricia, additional, Sánchez, Demetrio, additional, Barroso, Emilio, additional, Molina, Igor, additional, Budiño, Marco Antonio, additional, Masjuan, Jaime, additional, de Felipe, Alicia, additional, Matute, Consuelo, additional, Tejada, Javier, additional, Morán, Alberto, additional, Fernández, Esther, additional, Riveira, M. del Carmen, additional, Carnedo, Joaquín, additional, Manquillo, Antonio, additional, González, Raquel, additional, Fernández, José Carlos, additional, Guillan, Marta, additional, Yebra, Miguel, additional, Trejo, José M., additional, Saiz, Jesús, additional, Martínez-Acitores, Juan Carlos, additional, Bravo, Yolanda, additional, Arenillas, Juan Francisco, additional, Calleja, Ana, additional, Cortijo, Elisa, additional, Reyes, Javier, additional, López, Luis, additional, Muñoz, Pedro Luis, additional, Fidalgo, M. Ángeles, additional, Hernández, Jacinto, additional, Gómez, José Carlos, additional, Morán, José Carlos, additional, Gonzalo, Sonia, additional, Marrero, Jorge, additional, Satué, José Ángel, additional, Belinchón, Juan Carlos, additional, Moniche, Francisco, additional, Calderón, Enrique, additional, Escudero, Irene, additional, de la Torre, Javier, additional, Casado, Ignacio, additional, Antón, Joaquín, additional, Portilla, Juan Carlos, additional, Luengo, Juan, additional, Rosal, Joan, additional, Calzado, Elena, additional, Anglada, Juan Carlos, additional, Girón, Juan, additional, Ramírez, José M., additional, Pijierro, Agustín, additional, Roa, Ana, additional, Romero, Jorge, additional, Aguayo, Mariano, additional, Borrachero, Cristina, additional, Sanz, Gema, additional, Gómez, M. José, additional, Rico, Miguel Ángel, additional, Cayon, Antonio, additional, Carmona, Eduardo, additional, Cerro, Román, additional, López, Rafael, additional, Aguirre, Alfonso, additional, Lozano, Francisco, additional, and Rivera, José M., additional

Published
2018
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29. Factores asociados al mal control de la anticoagulación con antivitamina K en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author

Contreras Muruaga, M.M., primary, Reig, G., additional, Vivancos, J., additional, González, A., additional, Cardona, P., additional, Ramírez-Moreno, J.M., additional, Martí-Fábregas, J., additional, Suárez Fernández, C., additional, Pose, Antonio, additional, Díaz, José Antonio, additional, Rodríguez, Manuel, additional, Pena, Marta, additional, Arias, Susana, additional, Larrosa, Davinia, additional, González, Álvaro, additional, Rodríguez, Elisa, additional, González, Montserrat, additional, Fernández, Dolores, additional, Barbagelata, Cristina, additional, Raña, Natividad, additional, Freire, Santiago, additional, Cerqueiro, J. Manuel, additional, Guerrero, Héctor, additional, Ramos, Laura, additional, Álvarez, Leticia, additional, de Lis, José M., additional, Caro, Carmen, additional, Seijo, Manuel, additional, Mederer, Susana, additional, de Zarraga, Miguel Alberto, additional, Ferreiro, José, additional, Terrero, José M., additional, Arias, Mónica, additional, Pérez, Roberto, additional, Sánchez, Joaquín, additional, Maciñeiras, José, additional, Fernández, Julián, additional, Jaén, Fernando, additional, Esteva, David, additional, Zamora, Mónica, additional, Navarrete, Nuria, additional, García, Javier, additional, Mérida, Luis, additional, Corrales, Miguel Ángel, additional, Quirós, Raúl, additional, Cantero, Jesús, additional, Barrero, Francisco Javier, additional, Villegas, Inmaculada, additional, Castro, José, additional, Foronda, Jesús, additional, Carrillo, Dionisio, additional, Vega, Jesús, additional, Trujillo, José Antonio, additional, Montero, Manuel, additional, Jurado, Ana, additional, Sánchez, Carlos, additional, Agüera-Morales, Eduardo, additional, Sánchez, María, additional, Durán, Purificación, additional, Fernández de la Puerta, Rafael, additional, Pérez de la Blanca, María, additional, Martínez, María Paz, additional, Fernández, Óscar, additional, Tamayo, José Antonio, additional, Bustamante, Rafael, additional, Serrano, Pedro Jesús, additional, Arjona, Antonio, additional, Fernández, Javier, additional, Payan, Manuel, additional, Gómez, Ricardo, additional, Peña, Daniel, additional, Cabrerizo, Enrique, additional, Salgado, Fernando, additional, Ivanova Georgieva, Radka, additional, Gil-Núñez, Antonio, additional, Bello, Elena, additional, Díaz, Fernando, additional, Medina, Antonio, additional, Castellano, Ana, additional, Miranda, Yesica, additional, Fabre, Óscar, additional, García Polo, Iluminada, additional, Ibáñez, Patricia, additional, Sainz, Clara, additional, Sierra, Fernando, additional, Aragón, Esther, additional, Díaz, Jaime, additional, Aguilar, Fernando, additional, Ortega, María Ángeles, additional, Egido, José Antonio, additional, Pontes, José Carlos, additional, García, Miguel Ángel, additional, Cabrera, Francisco, additional, Batalla, Blanca, additional, Culla, Alex, additional, Molina, Carlos, additional, Flores, Alan, additional, Seró, Laia, additional, Muchada, Marian, additional, Meler, Pilar, additional, Boned-Riera, Sandra, additional, Cánovas, David, additional, Estela, Jordi, additional, Font, Juli, additional, Purroy, Francisco, additional, Benabdelhak, Ikram, additional, Sanahuja, Jordi, additional, Roquer, Jaume, additional, Rodríguez, Ana, additional, Ois, Ángel, additional, Cuadrado, Elisa, additional, Jiménez, Jordi, additional, Nogués, Xavier, additional, Kuprinski, Jerzy, additional, German, Antoni, additional, Irigoyen, Daniel, additional, Cara, Juan José, additional, Font, Maria Àngels, additional, Huertas, Sonia, additional, Martínez-Domeño, Alejandro, additional, Arroyo, Juan Antonio, additional, Delgado-Mederos, Raquel, additional, Gómez-Choco, Manuel Jesús, additional, Mengual, Juan José, additional, García, Sonia M., additional, Castellanos, M. del Mar, additional, van Eedenburg, Cecile, additional, Cañas, Imma, additional, Espinosa, Jordi, additional, Montull, Santiago, additional, Quesada, Helena, additional, Ustrell, Xavier, additional, Homedes, Christian, additional, Navalpotro, Irene, additional, Casanova, Jordi, additional, Lago, Aida Pilar, additional, Morata, Carmen, additional, Gorriz, David, additional, Moreno, Iván, additional, Tembl, José, additional, Ponz, Alejandro, additional, Fonseca, M. José, additional, Chamarro, Raquel, additional, Gil, Rosario, additional, Oliver, Vicente, additional, Pampliega, Ana, additional, Artero, Arturo, additional, Puchades, Francesc, additional, Landete, Lamberto, additional, Vilar, Carlos, additional, Jiménez, Carmen, additional, Vives, Bárbara, additional, Moragues, M. Dolores, additional, Díaz, Rosa, additional, Tur, Silvia, additional, Escribano, José Bernardo, additional, Lucas, César, additional, Martínez, Francisco, additional, Pons, José Miguel, additional, Romero, Amparo, additional, García, David, additional, Pérez, José, additional, Villaverde, Ramón, additional, Martínez, Salvadora, additional, Rodríguez, Aida, additional, Tejero, Carlos, additional, Pérez, Cristina, additional, Mostacero, Enrique, additional, Fernández, Covadonga, additional, Luna, Alain, additional, Pérez, Tomás, additional, González, Félix, additional, de Arce, Ana, additional, Martínez, Maite, additional, Díez, Noemí, additional, Gállego, Jaime, additional, Zandio, Beatriz, additional, Herrera, María, additional, Aymerich, Nuria, additional, Muñoz, Roberto, additional, Marta, Javier, additional, Artal, Jorge, additional, Errea, José M., additional, Timiraos, Juan José, additional, Moreno, M. Pilar, additional, Freijo, Mar, additional, García, Juan Manuel, additional, Gil, M. Carmen, additional, Revilla, M. Ángeles, additional, Palacio, Enrique, additional, Vázquez, José Luis, additional, Bestué, María, additional, Latorre, Ana, additional, Calvo, Eva, additional, Ballester, Laura, additional, Serrano, Marta, additional, Juega, Jesús M., additional, López, M. Ángeles, additional, Irimia, Pablo, additional, Imaz, Laura, additional, Fuentes, Blanca, additional, Sanz, Borja Enrique, additional, Beltrán, Luis, additional, Ruiz, Gerardo, additional, Martínez, Patricia, additional, Sánchez, Demetrio, additional, Barroso, Emilio, additional, Molina, Igor, additional, Budiño, Marco Antonio, additional, Masjuan, Jaime, additional, de Felipe, Alicia, additional, Matute, Consuelo, additional, Tejada, Javier, additional, Morán, Alberto, additional, Fernández, Esther, additional, Riveira, M. del Carmen, additional, Carnedo, Joaquín, additional, Manquillo, Antonio, additional, González, Raquel, additional, Fernández, José Carlos, additional, Guillan, Marta, additional, Yebra, Miguel, additional, Trejo, José M., additional, Saiz, Jesús, additional, Martínez-Acitores, Juan Carlos, additional, Bravo, Yolanda, additional, Arenillas, Juan Francisco, additional, Calleja, Ana, additional, Cortijo, Elisa, additional, Reyes, Javier, additional, López, Luis, additional, Muñoz, Pedro Luis, additional, Fidalgo, M. Ángeles, additional, Hernández, Jacinto, additional, Gómez, José Carlos, additional, Morán, José Carlos, additional, Gonzalo, Sonia, additional, Marrero, Jorge, additional, Satué, José Ángel, additional, Belinchón, Juan Carlos, additional, Moniche, Francisco, additional, Calderón, Enrique, additional, Escudero, Irene, additional, de la Torre, Javier, additional, Casado, Ignacio, additional, Antón, Joaquín, additional, Portilla, Juan Carlos, additional, Luengo, Juan, additional, Rosal, Joan, additional, Calzado, Elena, additional, Anglada, Juan Carlos, additional, Girón, Juan, additional, Ramírez, José M., additional, Pijierro, Agustín, additional, Roa, Ana, additional, Romero, Jorge, additional, Aguayo, Mariano, additional, Borrachero, Cristina, additional, Sanz, Gema, additional, Gómez, M. José, additional, Rico, Miguel Ángel, additional, Cayon, Antonio, additional, Carmona, Eduardo, additional, Cerro, Román, additional, López, Rafael, additional, Aguirre, Alfonso, additional, Lozano, Francisco, additional, and Rivera., José M., additional

Published
2018
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30. Abstract 153: Prior Statin Therapy is Not Associated With Cerebral Bleeding-prone Angiopathies in Patients With Ischemic Stroke Who Start Long-term Oral Anticoagulation

Author

Martí-Fàbregas, Joan, primary, Prats-Sánchez, Luis, additional, Camps-Renom, Pol, additional, Marín, Rebeca, additional, Delgado-Mederos, Raquel, additional, Martínez-Domeño, Alejandro, additional, Medrano, Santiago, additional, Merino, Elisa, additional, González de Echavarri, José María, additional, Rodriguez-Campello, Ana, additional, Cocho, Dolores, additional, Casado-Naranjo, Ignacio, additional, Fuentes, Blanca, additional, Gómez-Choco, Manuel, additional, Freijo, Mari Mar, additional, De Felipe, Alicia, additional, Canovas, David, additional, Bravo, Yolanda, additional, Lara, Lidia, additional, Calleja, Ana, additional, Sanahuja, Jordi, additional, Llull, Laura, additional, Hernández, María, additional, Zandio, Beatriz, additional, Lago, Aida, additional, Zedde, Marialuisa, additional, Boix, Amelia, additional, Reverté, Silvia, additional, De Arce-Bordas, Ana María, additional, and Palomeras, Ernest, additional

Published
2017
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35. Factores asociados al mal control de la anticoagulación con antivitaminaK en pacientes con fibrilación auricular no valvular atendidos en consultas de Medicina Interna y Neurología. Estudio ALADIN

Author

Contreras Muruaga, M.M., Reig, G., Vivancos, J., González, A., Cardona, P., Ramírez-Moreno, J.M., Martí-Fábregas, J., Suárez Fernández, C., Pose, Antonio, Díaz, José Antonio, Rodríguez, Manuel, Pena, Marta, Arias, Susana, Larrosa, Davinia, González, Álvaro, Rodríguez, Elisa, González, Montserrat, Fernández, Dolores, Barbagelata, Cristina, Raña, Natividad, Freire, Santiago, Cerqueiro, J. Manuel, Guerrero, Héctor, Ramos, Laura, Álvarez, Leticia, de Lis, José M., Caro, Carmen, Seijo, Manuel, Mederer, Susana, de Zarraga, Miguel Alberto, Ferreiro, José, Terrero, José M., Arias, Mónica, Pérez, Roberto, Sánchez, Joaquín, Maciñeiras, José, Fernández, Julián, Jaén, Fernando, Esteva, David, Zamora, Mónica, Navarrete, Nuria, García, Javier, Mérida, Luis, Corrales, Miguel Ángel, Quirós, Raúl, Cantero, Jesús, Barrero, Francisco Javier, Villegas, Inmaculada, Castro, José, Foronda, Jesús, Carrillo, Dionisio, Vega, Jesús, Trujillo, José Antonio, Montero, Manuel, Jurado, Ana, Sánchez, Carlos, Agüera-Morales, Eduardo, Sánchez, María, Durán, Purificación, Fernández de la Puerta, Rafael, Pérez de la Blanca, María, Martínez, María Paz, Fernández, Óscar, Tamayo, José Antonio, Bustamante, Rafael, Serrano, Pedro Jesús, Arjona, Antonio, Fernández, Javier, Payan, Manuel, Gómez, Ricardo, Peña, Daniel, Cabrerizo, Enrique, Salgado, Fernando, Ivanova Georgieva, Radka, Gil-Núñez, Antonio, Bello, Elena, Díaz, Fernando, Medina, Antonio, Castellano, Ana, Miranda, Yesica, Fabre, Óscar, García Polo, Iluminada, Ibáñez, Patricia, Sainz, Clara, Sierra, Fernando, Aragón, Esther, Díaz, Jaime, Aguilar, Fernando, Ortega, María Ángeles, Egido, José Antonio, Pontes, José Carlos, García, Miguel Ángel, Cabrera, Francisco, Batalla, Blanca, Culla, Alex, Molina, Carlos, Flores, Alan, Seró, Laia, Muchada, Marian, Meler, Pilar, Boned-Riera, Sandra, Cánovas, David, Estela, Jordi, Font, Juli, Purroy, Francisco, Benabdelhak, Ikram, Sanahuja, Jordi, Roquer, Jaume, Rodríguez, Ana, Ois, Ángel, Cuadrado, Elisa, Jiménez, Jordi, Nogués, Xavier, Kuprinski, Jerzy, German, Antoni, Irigoyen, Daniel, Cara, Juan José, Font, Maria Àngels, Huertas, Sonia, Martínez-Domeño, Alejandro, Arroyo, Juan Antonio, Delgado-Mederos, Raquel, Gómez-Choco, Manuel Jesús, Mengual, Juan José, García, Sonia M., Castellanos, M. del Mar, van Eedenburg, Cecile, Cañas, Imma, Espinosa, Jordi, Montull, Santiago, Quesada, Helena, Ustrell, Xavier, Homedes, Christian, Navalpotro, Irene, Casanova, Jordi, Lago, Aida Pilar, Morata, Carmen, Gorriz, David, Moreno, Iván, Tembl, José, Ponz, Alejandro, Fonseca, M. José, Chamarro, Raquel, Gil, Rosario, Oliver, Vicente, Pampliega, Ana, Artero, Arturo, Puchades, Francesc, Landete, Lamberto, Vilar, Carlos, Jiménez, Carmen, Vives, Bárbara, Moragues, M. Dolores, Díaz, Rosa, Tur, Silvia, Escribano, José Bernardo, Lucas, César, Martínez, Francisco, Pons, José Miguel, Romero, Amparo, García, David, Pérez, José, Villaverde, Ramón, Martínez, Salvadora, Rodríguez, Aida, Tejero, Carlos, Pérez, Cristina, Mostacero, Enrique, Fernández, Covadonga, Luna, Alain, Pérez, Tomás, González, Félix, de Arce, Ana, Martínez, Maite, Díez, Noemí, Gállego, Jaime, Zandio, Beatriz, Herrera, María, Aymerich, Nuria, Muñoz, Roberto, Marta, Javier, Artal, Jorge, Errea, José M., Timiraos, Juan José, Moreno, M. Pilar, Freijo, Mar, García, Juan Manuel, Gil, M. Carmen, Revilla, M. Ángeles, Palacio, Enrique, Vázquez, José Luis, Bestué, María, Latorre, Ana, Calvo, Eva, Ballester, Laura, Serrano, Marta, Juega, Jesús M., López, M. Ángeles, Irimia, Pablo, Imaz, Laura, Fuentes, Blanca, Sanz, Borja Enrique, Beltrán, Luis, Ruiz, Gerardo, Martínez, Patricia, Sánchez, Demetrio, Barroso, Emilio, Molina, Igor, Budiño, Marco Antonio, Masjuan, Jaime, de Felipe, Alicia, Matute, Consuelo, Tejada, Javier, Morán, Alberto, Fernández, Esther, Riveira, M. del Carmen, Carnedo, Joaquín, Manquillo, Antonio, González, Raquel, Fernández, José Carlos, Guillan, Marta, Yebra, Miguel, Trejo, José M., Saiz, Jesús, Martínez-Acitores, Juan Carlos, Bravo, Yolanda, Arenillas, Juan Francisco, Calleja, Ana, Cortijo, Elisa, Reyes, Javier, López, Luis, Muñoz, Pedro Luis, Fidalgo, M. Ángeles, Hernández, Jacinto, Gómez, José Carlos, Morán, José Carlos, Gonzalo, Sonia, Marrero, Jorge, Satué, José Ángel, Belinchón, Juan Carlos, Moniche, Francisco, Calderón, Enrique, Escudero, Irene, de la Torre, Javier, Casado, Ignacio, Antón, Joaquín, Portilla, Juan Carlos, Luengo, Juan, Rosal, Joan, Calzado, Elena, Anglada, Juan Carlos, Girón, Juan, Ramírez, José M., Pijierro, Agustín, Roa, Ana, Romero, Jorge, Aguayo, Mariano, Borrachero, Cristina, Sanz, Gema, Gómez, M. José, Rico, Miguel Ángel, Cayon, Antonio, Carmona, Eduardo, Cerro, Román, López, Rafael, Aguirre, Alfonso, Lozano, Francisco, and Rivera., José M.

Abstract

Identificar los factores asociados con el mal control de la anticoagulación con antagonistas de la vitaminaK (AVK) en pacientes con fibrilación auricular no valvular (FANV) atendidos en consultas de Neurología y Medicina Interna de España.

Published
2018
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41. Late clinical and radiological complications of stereotactical radiosurgery of arteriovenous malformations of the brain.

Author

Parkhutik, Vera, Lago, Aida, Aparici, Fernando, Vazquez, Juan, Tembl, Jose, Guillen, Lourdes, Mainar, Esperanza, and Vazquez, Victor

Subjects
*BRAIN surgery, *CONFIDENCE intervals, *LONGITUDINAL method, *HEALTH outcome assessment, *RADIATION injuries, *RADIOSURGERY, *STATISTICS, *SURGICAL complications, *MULTIPLE regression analysis, *TREATMENT effectiveness, *ARTERIOVENOUS malformation, *DESCRIPTIVE statistics, *KAPLAN-Meier estimator
Abstract

Introduction: Post-radiation injury of patients with brain arteriovenous malformations (AVM) include blood-brain barrier breakdown (BBBB), edema, and necrosis. Prevalence, clinical relevance, and response to treatment are poorly known. We present a series of consecutive brain AVM treated with stereotactic radiosurgery describing the appearance of radiation injury and clinical complications. Methods: Consecutive patients with annual clinical and radiological follow-up (median length 63 months). Edema and BBBB were classified in four groups (minimal, perilesional, moderate, or severe), and noted together with necrosis. Clinical symptoms of interest were intracranial hypertension, new neurological deficits, new seizures, and brain hemorrhages. Results: One hundred two cases, median age 34 years, 52 % male. Median irradiated volume 3.8 cc, dose to the margin of the nidus 18.5 Gy. Nineteen patients underwent a second radiosurgery. Only 42.2 % patients remained free from radiation injury. Edema was found in 43.1 %, blood-brain barrier breakdown in 20.6 %, necrosis in 6.9 %. Major injury (moderate or severe edema, moderate or severe BBBB, or necrosis) was found in 20 of 102 patients (19.6 %). AVM diameter >3 cm and second radiosurgery were independent predictors. Time to the worst imaging was 60 months. Patients with major radiation injury had a hazard ratio for appearance of focal deficits of 7.042 ( p = 0.04), of intracranial hypertension 2.857 ( p = 0.025), hemorrhage into occluded nidus 9.009 ( p = 0.079), appearance of new seizures not significant. Conclusions: Major radiation injury is frequent and increases the risk of neurological complications. Its late appearance implies that current follow-up protocols need to be extended in time. [ABSTRACT FROM AUTHOR]

Published
2013
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42. Long-term outcome in patients with carotid artery stenting and contralateral carotid occlusion: a single neurovascular center prospective analysis.

Author

Lago, Aida, Parkhutik, Vera, Tembl, Jose, Aparici, Fernando, Mainar, Esperanza, Alcalá, Carmen, and Vázquez-Añón, Víctor

Subjects
*ASPIRIN, *CEREBRAL angiography, *CHI-squared test, *LONGITUDINAL method, *MAGNETIC resonance imaging, *MYOCARDIAL infarction, *HEALTH outcome assessment, *RESEARCH funding, *SEX distribution, *SURGICAL stents, *SURVIVAL analysis (Biometry), *T-test (Statistics), *DISEASE relapse, *TREATMENT effectiveness, *CLOPIDOGREL, *DESCRIPTIVE statistics, *KAPLAN-Meier estimator, CAROTID artery stenosis
Abstract

Introduction: The aim of this study was to analyze the clinical features and early and late outcome of patients treated with carotid artery stenting for carotid stenosis with occlusion of the contralateral vessel (CAS-CCO), and compare them to patients without occlusion (CAS-NO). Methods: From 1999 through 2010, 426 patients with 479 procedures were prospectively recorded, 61 patients (14.3%) CAS-CCO, and 365 patients CAS-NO. Immediate CAS complications, complications within the first 30 days and long-term complications were documented through annual clinical and ultrasonological follow-up visits. Stenosis rate was recorded. Results: Patients with mean age of 68.4 years, 80% men had: (1) periprocedural stroke in three cases (0.7%), (2) cumulative 30-day stroke, ischemic cardiopathy, and death in 4.2%, without differences between groups (CAS-CCO 3.3%, CAS-NO 4.4%). Mean follow-up period was 55 ± 32.78 months, median 56 months. (3) Stroke during the follow-up in 8%, without differences between CAS-CCO and CAS-NO groups (3.7% and 8.8%). (4) Myocardial infarction in 11.2% and (5) global mortality in 24.3%, without statistical differences between groups. Of the 254 cases enrolled in the restenosis analysis, 44 patients (17.3%) had restenosis of any grade during a mean follow-up period of 52 months, without statistical differences between CAS-CCO and CAS-NO groups. Only 7.5% presented restenosis ≥ 50%. Its occurrence was statistically associated with previous neck radiation. Conclusions: Periprocedural risks and long-term outcomes of patients treated with CAS and presenting a contralateral carotid occlusion does not differ from regular patients treated with CAS. Based on the low stenosis rate of our study, our results do not give credit to extra surveillance measures in patients with contralateral carotid occlusion. [ABSTRACT FROM AUTHOR]

Published
2012
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44. Migraine, patent foramen ovale and migraine triggers.

Author

Tembl, Jose, Lago, Aida, Sevilla, Teresa, Solis, Pilar, and Vilchez, Juan

Subjects
*MIGRAINE aura, *VISION disorders, *NEUROLOGIC manifestations of general diseases, *HEADACHE, MIGRAINE complications
Abstract

Little information exists about a causal association between PFO and migraine. Some patients identify Valsalva-provoking activities (VPA) as migraine triggers. Therefore, we speculate about a pathogenic connection. The object of the study is to investigate the prevalence of right-to-left shunt (RLS) in a cohort of patients suffering migraine with aura (MA) and its possible association with migraine attacks triggered by VPA. We investigated the circumstances triggering the migraine attacks, in a consecutive series of 72 MA patients and in a series of migraine without aura age and gender-matched. The presence and extent of RLS was assessed by transcranial Doppler. Massive RLS appeared in 38.9% of MA and in 6.5% of migraine without aura ( p<0.001). MA patients identified at least one VPA as headache trigger in 45.8%. A trend was found between these triggering activities and massive RLS, both in MAgroup OR 2.7 [1.02–7.17] and in all migraine patients OR 2.5 [1.01–6.11]. According to our results, patients with migraine who have larger RLS tend to recognize activities that increase the extent of the shunt as a trigger of their migraine attacks. [ABSTRACT FROM AUTHOR]

Published
2007
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46. [Long-term development of carotid stenosis treated by endovascular means: a prospective study in a neurovascular unit].

Author

Lago A, Aparici-Robles F, Parkhutik V, Tembl JI, Mainar E, Vázquez-Añón V, and Claramonte B

Subjects
Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Postoperative Complications epidemiology, Prospective Studies, Recurrence, Time Factors, Carotid Stenosis surgery, Endarterectomy, Carotid adverse effects, Endovascular Procedures adverse effects
Abstract

Aims: Even today, unlike endarterectomy, long-term development in carotid angioplasty has still not been well defined. The aim of this study is to describe both the short- and long-term development and the rate of restenosis in a consecutive series of patients with carotid stenosis who underwent endovascular treatment at the Hospital Universitario La Fe; a distinction is made between patients with and without symptoms., Patients and Methods: From 1999 to 2010, 426 patients were submitted to a carotid angioplasty (25.5% were asymptomatic patients). Clinical follow-ups were conducted in the case of 374 patients. They had annual check-ups and every year a neurosonological study was performed. The aim was to determine what complications occurred during the first 30 days, as well as the long-term complications, to establish the rate of restenosis and to evaluate possible differences between patients with and without symptoms., Results: The morbidity and mortality rate in the first month was 4.2% (4.4% in symptomatic patients and 3.8% in asymptomatic patients). The mean follow-up time was 55 months: 8% of patients presented strokes, 11% suffered from myocardial infarct and 24.3% died, with no significant differences between patients with or without symptoms. The rate of restenosis was 17.3% at five years, 7.5% equal to or above 50% and, of those, 1.1% were symptomatic. Five patients with significant restenosis were successfully treated with endovascular techniques., Conclusions: Carotid angioplasty is an effective, safe technique in the hands of an experienced professional; our findings are good, both in the short and the long term, with a low rate of restenosis. If this latter condition occurs, vascular intervention techniques are safe and efficient.

Published
2011

47. [Who controls arteriovenous malformations of the brain without surgery in Spain?].

Author

Parkhutik V, Lago A, Tembl JI, Sahuquillo P, and Freire-Alvarez E

Subjects
Arteriovenous Malformations diagnosis, Humans, Neurosurgical Procedures adverse effects, Spain, Treatment Outcome, Arteriovenous Malformations therapy, Brain abnormalities, Radiosurgery methods, Radiosurgery statistics & numerical data
Published
2010

48. [Clinical usefulness of transcranial Doppler in diagnosis of brain death].

Author

Fages E, Tembl JI, Fortea G, López P, Lago A, Vicente JL, and Vilchez JJ

Subjects
Adolescent, Adult, Aged, Humans, Male, Middle Aged, Brain Death diagnostic imaging, Ultrasonography, Doppler, Transcranial
Abstract

Background and Objective: The use of transcranial doppler (TD) for the assessment of critical neurological patients and brain death (BD) is steadily growing. In this study we describe the daily clinical practice around BD diagnosis and compare the usefulness of TD, including advantages and shortcomings, with that of other tests., Patients and Method: A series of 100 patients diagnosed of brain death is presented including the demographic and clinical data as well as the results of ancillary tests (CE)., Results: Fifty eight patients were males with a mean age of 46. The most frequent etiology of coma was spontaneous cerebral hemorrhage. Central nervous system depressants had been administered to 62 patients within a few hours prior to the diagnosis. When ancillary tests were performed, only 55% patients fulfilled the currently accepted clinical criteria for brain death. TD was performed in 44 patients and 80% of them showed a pattern supporting a brain death diagnosis. Definitive diagnostic tests were electroencephalogram (EEG) in 53% patients and TD in 35% of them. In ten cases, discrepancies were observed between the results offered by these tests., Conclusions: Transcraneal Doppler stands out as a safe, fast, inexpensive and bloodless method of assessment of the critical neurological patient and for BD diagnosis. It is the choice test in the presence of central nervous system depressant drugs, abuse of substances or coma of unknown etiology. The main limitations of this technique are the presence of extensive craniotomies and the absence of an adequate acoustic window.

Published
2004
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