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2. Data from Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers

Author

Bialucha, Carl U., primary, Collins, Scott D., primary, Li, Xiao, primary, Saxena, Parmita, primary, Zhang, Xiamei, primary, Dürr, Clemens, primary, Lafont, Bruno, primary, Prieur, Pierric, primary, Shim, Yeonju, primary, Mosher, Rebecca, primary, Lee, David, primary, Ostrom, Lance, primary, Hu, Tiancen, primary, Bilic, Sanela, primary, Rajlic, Ivana Liric, primary, Capka, Vladimir, primary, Jiang, Wei, primary, Wagner, Joel P., primary, Elliott, GiNell, primary, Veloso, Artur, primary, Piel, Jessica C., primary, Flaherty, Meghan M., primary, Mansfield, Keith G., primary, Meseck, Emily K., primary, Rubic-Schneider, Tina, primary, London, Anne Serdakowski, primary, Tschantz, William R., primary, Kurz, Markus, primary, Nguyen, Duc, primary, Bourret, Aaron, primary, Meyer, Matthew J., primary, Faris, Jason E., primary, Janatpour, Mary J., primary, Chan, Vivien W., primary, Yoder, Nicholas C., primary, Catcott, Kalli C., primary, McShea, Molly A., primary, Sun, Xiuxia, primary, Gao, Hui, primary, Williams, Juliet, primary, Hofmann, Francesco, primary, Engelman, Jeffrey A., primary, Ettenberg, Seth A., primary, Sellers, William R., primary, and Lees, Emma, primary

Published
2023
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3. Supplementary Figure Legends from Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers

Author

Bialucha, Carl U., primary, Collins, Scott D., primary, Li, Xiao, primary, Saxena, Parmita, primary, Zhang, Xiamei, primary, Dürr, Clemens, primary, Lafont, Bruno, primary, Prieur, Pierric, primary, Shim, Yeonju, primary, Mosher, Rebecca, primary, Lee, David, primary, Ostrom, Lance, primary, Hu, Tiancen, primary, Bilic, Sanela, primary, Rajlic, Ivana Liric, primary, Capka, Vladimir, primary, Jiang, Wei, primary, Wagner, Joel P., primary, Elliott, GiNell, primary, Veloso, Artur, primary, Piel, Jessica C., primary, Flaherty, Meghan M., primary, Mansfield, Keith G., primary, Meseck, Emily K., primary, Rubic-Schneider, Tina, primary, London, Anne Serdakowski, primary, Tschantz, William R., primary, Kurz, Markus, primary, Nguyen, Duc, primary, Bourret, Aaron, primary, Meyer, Matthew J., primary, Faris, Jason E., primary, Janatpour, Mary J., primary, Chan, Vivien W., primary, Yoder, Nicholas C., primary, Catcott, Kalli C., primary, McShea, Molly A., primary, Sun, Xiuxia, primary, Gao, Hui, primary, Williams, Juliet, primary, Hofmann, Francesco, primary, Engelman, Jeffrey A., primary, Ettenberg, Seth A., primary, Sellers, William R., primary, and Lees, Emma, primary

Published
2023
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4. Supplementary Figures 1 through 7 from Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers

Author

Bialucha, Carl U., primary, Collins, Scott D., primary, Li, Xiao, primary, Saxena, Parmita, primary, Zhang, Xiamei, primary, Dürr, Clemens, primary, Lafont, Bruno, primary, Prieur, Pierric, primary, Shim, Yeonju, primary, Mosher, Rebecca, primary, Lee, David, primary, Ostrom, Lance, primary, Hu, Tiancen, primary, Bilic, Sanela, primary, Rajlic, Ivana Liric, primary, Capka, Vladimir, primary, Jiang, Wei, primary, Wagner, Joel P., primary, Elliott, GiNell, primary, Veloso, Artur, primary, Piel, Jessica C., primary, Flaherty, Meghan M., primary, Mansfield, Keith G., primary, Meseck, Emily K., primary, Rubic-Schneider, Tina, primary, London, Anne Serdakowski, primary, Tschantz, William R., primary, Kurz, Markus, primary, Nguyen, Duc, primary, Bourret, Aaron, primary, Meyer, Matthew J., primary, Faris, Jason E., primary, Janatpour, Mary J., primary, Chan, Vivien W., primary, Yoder, Nicholas C., primary, Catcott, Kalli C., primary, McShea, Molly A., primary, Sun, Xiuxia, primary, Gao, Hui, primary, Williams, Juliet, primary, Hofmann, Francesco, primary, Engelman, Jeffrey A., primary, Ettenberg, Seth A., primary, Sellers, William R., primary, and Lees, Emma, primary

Published
2023
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5. Supplementary Material and Methods from Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers

Author

Bialucha, Carl U., primary, Collins, Scott D., primary, Li, Xiao, primary, Saxena, Parmita, primary, Zhang, Xiamei, primary, Dürr, Clemens, primary, Lafont, Bruno, primary, Prieur, Pierric, primary, Shim, Yeonju, primary, Mosher, Rebecca, primary, Lee, David, primary, Ostrom, Lance, primary, Hu, Tiancen, primary, Bilic, Sanela, primary, Rajlic, Ivana Liric, primary, Capka, Vladimir, primary, Jiang, Wei, primary, Wagner, Joel P., primary, Elliott, GiNell, primary, Veloso, Artur, primary, Piel, Jessica C., primary, Flaherty, Meghan M., primary, Mansfield, Keith G., primary, Meseck, Emily K., primary, Rubic-Schneider, Tina, primary, London, Anne Serdakowski, primary, Tschantz, William R., primary, Kurz, Markus, primary, Nguyen, Duc, primary, Bourret, Aaron, primary, Meyer, Matthew J., primary, Faris, Jason E., primary, Janatpour, Mary J., primary, Chan, Vivien W., primary, Yoder, Nicholas C., primary, Catcott, Kalli C., primary, McShea, Molly A., primary, Sun, Xiuxia, primary, Gao, Hui, primary, Williams, Juliet, primary, Hofmann, Francesco, primary, Engelman, Jeffrey A., primary, Ettenberg, Seth A., primary, Sellers, William R., primary, and Lees, Emma, primary

Published
2023
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6. Supplementary Tables 1 through 11 from Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers

Author

Bialucha, Carl U., primary, Collins, Scott D., primary, Li, Xiao, primary, Saxena, Parmita, primary, Zhang, Xiamei, primary, Dürr, Clemens, primary, Lafont, Bruno, primary, Prieur, Pierric, primary, Shim, Yeonju, primary, Mosher, Rebecca, primary, Lee, David, primary, Ostrom, Lance, primary, Hu, Tiancen, primary, Bilic, Sanela, primary, Rajlic, Ivana Liric, primary, Capka, Vladimir, primary, Jiang, Wei, primary, Wagner, Joel P., primary, Elliott, GiNell, primary, Veloso, Artur, primary, Piel, Jessica C., primary, Flaherty, Meghan M., primary, Mansfield, Keith G., primary, Meseck, Emily K., primary, Rubic-Schneider, Tina, primary, London, Anne Serdakowski, primary, Tschantz, William R., primary, Kurz, Markus, primary, Nguyen, Duc, primary, Bourret, Aaron, primary, Meyer, Matthew J., primary, Faris, Jason E., primary, Janatpour, Mary J., primary, Chan, Vivien W., primary, Yoder, Nicholas C., primary, Catcott, Kalli C., primary, McShea, Molly A., primary, Sun, Xiuxia, primary, Gao, Hui, primary, Williams, Juliet, primary, Hofmann, Francesco, primary, Engelman, Jeffrey A., primary, Ettenberg, Seth A., primary, Sellers, William R., primary, and Lees, Emma, primary

Published
2023
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9. Use of BRASS in sedated critically-ill patients as a predictable mortality factor: BRASS-ICU.

Author

Legros, Vincent, Mourvillier, Bruno, Floch, Thierry, Candelier, Quentin, Rosman, Jeremy, Lafont, Bruno, Farkas, Jean-Christophe, Bard, Mathieu, Kanagaratnam, Lukshe, and Mateu, Philippe

Subjects
BRASS, MORTALITY, ARTIFICIAL respiration, SUFENTANIL, BRAIN stem
Abstract

Objectives: To demonstrate that a BRASS score≥ 3 at admission of intubated, ventilated and sedated patients is predictive of mortality Methods: we have realized an Observational prospective multicenter study. All Major patients without neurological history, admitted to ICU for a non-neurological cause, sedated and admitted under mechanical ventilation were included. Results: One hundred and ten patients were included, the BRASS score as well as the FOUR and RASS scores were collected. At day 28, patients with a BRASS score ≥ 3 had an excess mortality (OR 3.29 – CI 95% [1.42–7.63], p = 0.005) as well as day 90 (OR 2.65 – CI 95% [1.19–5.88], p = 0.02), without impact on the delirium measured by CAM-ICU (OR 1.8 – CI 95% [0.68–4.77], p = 0.023). After adjustment with SAPS II, FOUR and RASS, difference in mortality was not any more different. It is also noted that patients with BRASS ≥ 3 are more sedated (RASS: −5 [−5 – −5] vs −4 [−5 – −3], p < 0.0001) and more comatose (FOUR: 2 [1–4] vs 6 [4–9], p < 0.0001), and have higher doses of midazolam (10 mg/h [5–15] vs 7.5 mg/h [5–10], p = 0.02) and sufentanil (20 μg/h [15–22.5] vs 10 [10–12.5], p = 0.01). Conclusions: The early alteration of brainstem reflexes measured by the BRASS score was not independently predictable in terms of mortality in the non-neurological ICU patients, admitted under sedation and mechanical ventilation. Trial registration: ClinicalTrials.gov Identifier: NCT03835091,Registered 8 February 2019 – prospectively registered, [ABSTRACT FROM AUTHOR]

Published
2021
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10. Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers

Author

Bialucha, Carl U., primary, Collins, Scott D., additional, Li, Xiao, additional, Saxena, Parmita, additional, Zhang, Xiamei, additional, Dürr, Clemens, additional, Lafont, Bruno, additional, Prieur, Pierric, additional, Shim, Yeonju, additional, Mosher, Rebecca, additional, Lee, David, additional, Ostrom, Lance, additional, Hu, Tiancen, additional, Bilic, Sanela, additional, Rajlic, Ivana Liric, additional, Capka, Vladimir, additional, Jiang, Wei, additional, Wagner, Joel P., additional, Elliott, GiNell, additional, Veloso, Artur, additional, Piel, Jessica C., additional, Flaherty, Meghan M., additional, Mansfield, Keith G., additional, Meseck, Emily K., additional, Rubic-Schneider, Tina, additional, London, Anne Serdakowski, additional, Tschantz, William R., additional, Kurz, Markus, additional, Nguyen, Duc, additional, Bourret, Aaron, additional, Meyer, Matthew J., additional, Faris, Jason E., additional, Janatpour, Mary J., additional, Chan, Vivien W., additional, Yoder, Nicholas C., additional, Catcott, Kalli C., additional, McShea, Molly A., additional, Sun, Xiuxia, additional, Gao, Hui, additional, Williams, Juliet, additional, Hofmann, Francesco, additional, Engelman, Jeffrey A., additional, Ettenberg, Seth A., additional, Sellers, William R., additional, and Lees, Emma, additional

Published
2017
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