7 results on '"Laera, R."'
Search Results
2. Intracranial complications of sinogenic and otogenic infections in children:an ESPN survey on their occurrence in the pre-COVID and post-COVID era
- Author
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Massimi, L., Cinalli, G., Frassanito, P., Arcangeli, V., Auer, C., Baro, V., Bartoli, A., Bianchi, F., Dietvorst, S., Di Rocco, F., Gallo, P., Giordano, F., Hinojosa, J., Iglesias, S., Jecko, V., Kahilogullari, G., Knerlich-Lukoschus, F., Laera, R., Locatelli, D., Luglietto, D., Luzi, M., Messing-Jünger, M., Mura, R., Ragazzi, P., Riffaud, L., Roth, J., Sagarribay, A., Pinheiro, M. Santos, Spazzapan, P., Spennato, P., Syrmos, N., Talamonti, G., Valentini, L., Van Veelen, M. L., Zucchelli, M., Tamburrini, G., Massimi, L., Cinalli, G., Frassanito, P., Arcangeli, V., Auer, C., Baro, V., Bartoli, A., Bianchi, F., Dietvorst, S., Di Rocco, F., Gallo, P., Giordano, F., Hinojosa, J., Iglesias, S., Jecko, V., Kahilogullari, G., Knerlich-Lukoschus, F., Laera, R., Locatelli, D., Luglietto, D., Luzi, M., Messing-Jünger, M., Mura, R., Ragazzi, P., Riffaud, L., Roth, J., Sagarribay, A., Pinheiro, M. Santos, Spazzapan, P., Spennato, P., Syrmos, N., Talamonti, G., Valentini, L., Van Veelen, M. L., Zucchelli, M., and Tamburrini, G.
- Abstract
Background: COVID-19 pandemic is thought to have changed the epidemiology of some pediatric neurosurgical disease: among them are the intracranial complications of sinusitis and otitis (ICSO). According to some studies on a limited number of cases, both streptococci-related sinusitis and ICSO would have increased immediately after the pandemic, although the reason is not clear yet (seasonal changes versus pandemic-related effects). The goal of the present survey of the European Society for Pediatric Neurosurgery (ESPN) was to collect a large number of cases from different European countries encompassing the pre-COVID (2017–2019), COVID (2020–2021), and post-COVID period (2022–June 2023) looking for possible epidemiological and/or clinical changes. Material and methods: An English language questionnaire was sent to ESPN members about year of the event, patient’s age and gender, presence of immune-deficit or other favoring risk factors, COVID infection, signs and symptoms at onset, site of primary infection, type of intracranial complication, identified germ, type and number of surgical operations, type and duration of medical treatment, clinical and radiological outcome, duration of the follow-up. Results: Two hundred fifty-four cases were collected by 30 centers coming from 14 different European countries. There was a statistically significant difference between the post-COVID period (129 children, 86 cases/year, 50.7% of the whole series) and the COVID (40 children, 20 cases/year, 15.7%) or the pre-COVID period (85 children, 28.3 cases/year, 33.5%). Other significant differences concerned the presence of predisposing factors/concurrent diseases (higher in the pre-COVID period) and previous COVID infection (higher in the post-COVID period). No relevant differences occurred as far as demographic, microbiological, clinical, radiological, outcome, morbidity, and mortality data were concerned. Paranasal sinuses
- Published
- 2024
3. Idiopathic normal pressure hydrocephalus diagnosis: Quantitative and qualitative score predicting outcome of extended lumbar drainage.
- Author
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Laera R, Gorgoglione ML, Curcio A, Marzano G, Caruso G, Caffo M, and Germanò A
- Abstract
Image 1., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
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- 2024
- Full Text
- View/download PDF
4. Treatment of Chiari III Malformation in Infant with 4K 3D ORBEYE Exoscope.
- Author
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Gorgoglione ML, Laera R, Curcio A, Caruso G, Delia G, and Germanò AF
- Subjects
- Humans, Male, Infant, Child, Pregnancy, Female, Cesarean Section, Cerebellum, Shoulder Dystocia, Arnold-Chiari Malformation surgery, Hydrocephalus surgery
- Abstract
Chiari malformation (CM)-III is the rarest anomaly among CMs.
1 Treatment of choice is surgical repair,2 although poor outcome and postoperative mortality has been reported.3 Surgical timing is still debated.4 , 5 We present the case of a male infant with a prenatal diagnosis of encephalocele. Presentation was characterized by hemodynamic instability, horizontal nystagmus, and left shoulder dystocia due to caesarean section, with a 64 mm × 49 mm × 76 mm soft, fluctuant, and translucent suboccipital-cervical sac. Magnetic resonance imaging revealed a median occipital bone defect with the meningoencephalic sac communicating with the vermian cistern and the fourth ventricle, moderate hydrocephalus, reduction of the posterior cranial fossa volume, hypoplasia of cerebellar hemispheric, vermian structures, and corpus callosum hypoplasia. The patient underwent surgery on day 4 with the use of a 4K 3D ORBEYE exoscope (Video 1). Surgery consisted of disengagement of nervous structures and repair of the neurocutaneous defect, followed on day 12 by a ventriculoperitoneal shunt with a programmable valve. The procedures were well tolerated. At the 14-month follow-up visit he was in range with growth charts (weight, height, and cranic circumference) and gained the physiologic stages of growth. He had no motor impairment but still present were convergent strabismus and mild left C5-C6 radiculopathy, secondary to shoulder dystocia. This is the first case reported in the literature of CM-III treated with the 4K 3D ORBEYE exoscope. Advantages of the exoscope were ergonomic positions for operative staff, possibility for the team to assist in the 4K 3D view, especially in cases with a narrow operative field, with a clear and detailed vision, although a learning curve is required6 to become a valid alternative in pediatric neurosurgery., (Copyright © 2023 Elsevier Inc. All rights reserved.)- Published
- 2023
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5. The Role of Nanotechnology in Spinal Cord Tumors.
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Caffo M, Caruso G, Laera R, Curcio A, Cacciola F, Esposito E, and Germanò A
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- Humans, Drug Delivery Systems, Nanotechnology, Blood-Brain Barrier, Peptides chemistry, Pharmaceutical Preparations, Spinal Cord Neoplasms, Nanoparticles therapeutic use, Nanoparticles chemistry
- Abstract
The efficacy of current multimodal therapeutic strategies in spinal cord tumors is limited by the lack of specific therapies. Importantly, sufficient amount of therapeutic materials should be concentrated in tumors in order to be efficient. Overcoming the blood-brain barrier is the major obstacle for chemotherapeutics, which cannot reach the tumor bed in efficacious doses. The intrinsic properties of nanoparticles make them suitable for activating numerous processes both at the cellular and subcellular levels, making them good candidates to be used for different purposes in medicine. Furthermore, the adaptability characteristic of NPs may enable them to pass through the blood-brain barrier and transport different pharmacological compounds. Nanoparticle systems provide prolonged drug delivery directly to the tumor or by functionalizing the material surface with peptides and ligands allowing the drug-loaded material to specifically target the tumor cells. In this chapter, various preclinical and/or clinical studies in treatment of spinal cord tumors are discussed., (© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
- Published
- 2023
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6. The Role of Nanotechnologies in Brain Tumors.
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Caffo M, Caruso G, Curcio A, Laera R, Crisafulli C, Fazzari E, Passalacqua M, and Germanò A
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- Humans, Drug Delivery Systems methods, Blood-Brain Barrier metabolism, Nanotechnology, Pharmaceutical Preparations metabolism, Brain Neoplasms pathology, Glioma pathology, Glioblastoma pathology, Antineoplastic Agents therapeutic use, Antineoplastic Agents pharmacology, Nanoparticles therapeutic use
- Abstract
The treatment of glioma remains one of the most interesting topics in neurooncology. Glioblastoma multiforme is the most aggressive and prevalent malignant brain tumor. Nowadays, technologies and new tools are helping the neurosurgeons to define a tailored surgery. However, there are few pharmaceutical strategies in operated and nonoperated patients. There are still few anticancer drugs approved by FDA and EMA. Moreover, these drugs are not so effective and have a lot of side effects due to their toxicity. Nanoparticles are a new strategy which could help to create and carry new drugs. In fact, NPs improve the pharmacokinetic properties of anticancer drugs, reduce side-effects, and increase drug half-life and its selectivity. Nanoparticle drug delivery system has been studied for targeting different molecular biomarkers and signaling pathways. Furthermore, the first problem of anticancer drugs in the treatment of gliomas is penetrating the blood brain barrier which represents an insurmountable wall for most of synthetic and natural particles. In the last 15 years, a lot of researches tried to design a perfect nanoparticle both able to cross blood-brain barrier and to selectively target glioma cells, unfortunately, without great results. In vivo human trials are still ongoing and many of them have already failed. In this chapter we evaluate the effectiveness of nanotechnologies in the treatment of brain tumors. There is not yet, currently, a nanoparticle drug designed for the treatment of gliomas approved by FDA and EMA. Advancements in discovery of molecular characteristics of tumors lead to the development of targeted nanoparticles that are tested in numerous in vitro and in vivo studies on gliomas. Novel and repurposed drugs, as well as novel drug combinations, have also been already studied but those are not included in this chapter because the carried drugs (active substances) are not included among the approved anticancer drug used in the treatment of gliomas., (© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
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- 2023
- Full Text
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7. Comment on "Terson's syndrome, the current concepts and management strategies: A review of literature".
- Author
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Passalacqua M, Curcio A, Laera R, and Caruso G
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- Humans, Review Literature as Topic, Subarachnoid Hemorrhage, Vitreous Hemorrhage
- Published
- 2022
- Full Text
- View/download PDF
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