416 results on '"Ladoire, S"'
Search Results
2. Delayed nephrectomy after immunotherapy for metastatic renal cell carcinoma: Oncological outcomes and predictive factors of surgical difficulties
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Pignot, G., primary, Margue, G., additional, Bigot, P., additional, Lang, H., additional, Balssa, L., additional, Roubaud, G., additional, Borchiellini, D., additional, Bensalah, K., additional, Schlürmann, F., additional, Ladoire, S., additional, Parier, B., additional, Bernhard, J.C., additional, Cassuto, O., additional, Albiges, L., additional, Thibault, C., additional, Ingels, A., additional, Cherifi, F., additional, Waeckel, T., additional, Walz, J., additional, Flippot, R., additional, Geoffrois, L., additional, Gravis, G., additional, and Barthelemy, P., additional
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- 2024
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3. EAU–ESMO consensus statements on the management of advanced and variant bladder cancer—an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees
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Horwich, A., Babjuk, M., Bellmunt, J., Bruins, H.M., De Reijke, T.M., De Santis, M., Gillessen, S., James, N., Maclennan, S., Palou, J., Powles, T., Ribal, M.J., Shariat, S.F., Van Der Kwast, T., Xylinas, E., Agarwal, N., Arends, T., Bamias, A., Birtle, A., Black, P.C., Bochner, B.H., Bolla, M., Boormans, J.L., Bossi, A., Briganti, A., Brummelhuis, I., Burger, M., Castellano, D., Cathomas, R., Chiti, A., Choudhury, A., Compérat, E., Crabb, S., Culine, S., De Bari, B., DeBlok, W., De Visschere, P.J.L., Decaestecker, K., Dimitropoulos, K., Dominguez-Escrig, J.L., Fanti, S., Fonteyne, V., Frydenberg, M., Futterer, J.J., Gakis, G., Geavlete, B., Gontero, P., Grubmüller, B., Hafeez, S., Hansel, D.E., Hartmann, A., Hayne, D., Henry, A.M., Hernandez, V., Herr, H., Herrmann, K., Hoskin, P., Huguet, J., Jereczek-Fossa, B.A., Jones, R., Kamat, A.M., Khoo, V., Kiltie, A.E., Krege, S., Ladoire, S., Lara, P.C., Leliveld, A., Linares-Espinós, E., Løgager, V., Lorch, A., Loriot, Y., Meijer, R., Carmen Mir, M., Moschini, M., Mostafid, H., Müller, A.-C., Müller, C.R., N’Dow, J., Necchi, A., Neuzillet, Y., Oddens, J.R., Oldenburg, J., Osanto, S., Oyen, W.J.G., Pacheco-Figueiredo, L., Pappot, H., Patel, M.I., Pieters, B.R., Plass, K., Remzi, M., Retz, M., Richenberg, J., Rink, M., Roghmann, F., Rosenberg, J.E., Rouprêt, M., Rouvière, O., Salembier, C., Salminen, A., Sargos, P., Sengupta, S., Sherif, A., Smeenk, R.J., Smits, A., Stenzl, A., Thalmann, G.N., Tombal, B., Turkbey, B., Vahr Lauridsen, S., Valdagni, R., Van Der Heijden, A.G., Van Poppel, H., Vartolomei, M.D., Veskimäe, E., Vilaseca, A., Vives Rivera, F.A., Wiegel, T., Wiklund, P., Williams, A., Zigeuner, R., and Witjes, J.A.
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- 2019
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4. Pourquoi l’urologue doit s’intéresser à l’immunothérapie, quelles sont les indications établies en 2018 et celles en perspectives ?
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Boissier, R. and Ladoire, S.
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- 2018
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5. Impact of contemporary patterns of chemotherapy utilization on survival in patients with advanced cancer of the urinary tract: a Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC)
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Bamias, A., Tzannis, K., Harshman, L.C., Crabb, S.J., Wong, Y.-N., Kumar Pal, S., De Giorgi, U., Ladoire, S., Agarwal, N., Yu, E.Y., Niegisch, G., Necchi, A., Sternberg, C.N., Srinivas, S., Alva, A., Vaishampayan, U., Cerbone, L., Liontos, M., Rosenberg, J., Powles, T., Bellmunt, J., and Galsky, M.D.
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- 2018
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6. A randomized, double-blind, placebo-controlled phase II study of maintenance therapy with tasquinimod in patients with metastatic castration-resistant prostate cancer responsive to or stabilized during first-line docetaxel chemotherapy
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Fizazi, K., Ulys, A., Sengeløv, L., Moe, M., Ladoire, S., Thiery-Vuillemin, A., Flechon, A., Guida, A., Bellmunt, J., Climent, M.A., Chowdhury, S., Dumez, H., Matouskova, M., Penel, N., Liutkauskiene, S., Stachurski, L., Sternberg, C.N., Baton, F., Germann, N., and Daugaard, G.
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- 2017
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7. 263P Cross-sectional nationwide population-based study of living conditions, and identification of sexual and fertility profiles among young women after breast cancer in France: A study of the French Network of Cancer Registries (FRANCIM)
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Assogba, E., primary, Mollevi, C., additional, Woronoff, A-S., additional, Dumas, A., additional, Coutant, C., additional, Desmoulins, I., additional, Ladoire, S., additional, and Dabakuyo-Yonli, S., additional
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- 2023
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8. 213MO Primary endpoint analysis of a randomized phase II of darolutamide or capecitabine in patients with triple-negative androgen receptor-positive advanced breast cancer (UCBG3-06 START trial)
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Arnedos, M., primary, Goncalves, A., additional, Pulido, M., additional, Lerebours, F., additional, Tredan, O., additional, Dalenc, F., additional, Guiu, S., additional, Mollon Grange, D., additional, Teixeira, L., additional, Levy, C., additional, Verret, B., additional, Dawood, H.A.S., additional, Augereau, P., additional, Deiana, L., additional, Ladoire, S., additional, Carola, E., additional, Mouret Reynier, M.A., additional, Guyonneau, C., additional, MacGrogan, G., additional, and Bonnefoi, H., additional
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- 2022
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9. 1480P Baseline levels of proinflammatory cytokines according to body mass index (BMI) and BMI impact on clinical outcomes in metastatic renal cell carcinoma (mRCC) patients (pts) treated with nivolumab (NIVO) within the NIVOREN trial
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Colomba, E., primary, Carril Ajuria, L., additional, Dalban, C., additional, Derosa, L., additional, Alves Costa Silva, C., additional, Rassy, E., additional, Negrier, S., additional, Chevreau, C.M., additional, Gravis Mescam, G., additional, Oudard, S., additional, Laguerre, B., additional, Barthelemy, P., additional, Gross Goupil, M., additional, Geoffrois, L., additional, Thiery-Vuillemin, A., additional, Joly Lobbedez, F., additional, Ladoire, S., additional, Tantot, F., additional, Escudier, B., additional, and Albiges, L., additional
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- 2022
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10. EAU-ESMO consensus statements on the management of advanced and variant bladder cancer
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Witjes JA, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Van der Kwast T, Xylinas E, Agarwal N, Arends T, Bamias A, Birtle A, Black PC, Bochner BH, Bolla M, Boormans JL, Bossi A, Briganti A, Brummelhuis I, Burger M, Castellano D, Cathomas R, Chiti A, Choudhury A, Comperat E, Crabb S, Culine S, De Bari B, De Blok W, De Visschere PJL, Decaestecker K, Dimitropoulos K, Dominguez-Escrig JL, Fanti S, Fonteyne V, Frydenberg M, Futterer JJ, Gakis G, Geavlete B, Gontero P, Grubmuller B, Hafeez S, Hansel DE, Hartmann A, Hayne D, Henry AM, Hernandez V, Herr H, Herrmann K, Hoskin P, Huguet J, Jereczek-Fossa BA, Jones R, Kamat AM, Khoo V, Kiltie AE, Krege S, Ladoire S, Lara PC, Leliveld A, Linares-Espinos E, Logager V, Lorch A, Loriot Y, Meijer R, Mir MC, Moschini M, Mostafid H, Muller AC, Muller CR, N'Dow J, Necchi A, Neuzillet Y, Oddens JR, Oldenburg J, Osanto S, Oyen WJG, Pacheco-Figueiredo L, Pappot H, Patel MI, Pieters BR, Plass K, Remzi M, Retz M, Richenberg J, Rink M, Roghmann F, Rosenberg JE, Roupret M, Rouviere O, Salembier C, Salminen A, Sargos P, Sengupta S, Sherif A, Smeenk RJ, Smits A, Stenzl A, Thalmann GN, Tombal B, Turkbey B, Lauridsen SV, Valdagni R, Van der Heijden AG, Van Poppel H, Vartolomei MD, Veskimae E, Vilaseca A, Rivera FAV, Wiegel T, Wiklund P, Williams A, Zigeuner R, Horwich A, Witjes JA, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Der Kwast TV, Xylinas E, Agarwal N, Arends T, Bamias A, Birtle A, Black PC, Bochner BH, Bolla M, Boormans JL, Bossi A, Briganti A, Brummelhuis I, Burger M, Castellano D, Cathomas R, Chiti A, Choudhury A, Compérat E, Crabb S, Culine S, De Bari B, De Blok W, J L De Visschere P, Decaestecker K, Dimitropoulos K, Dominguez-Escrig JL, Fanti S, Fonteyne V, Frydenberg M, Futterer JJ, Gakis G, Geavlete B, Gontero P, Grubmüller B, Hafeez S, Hansel DE, Hartmann A, Hayne D, Henry AM, Hernandez V, Herr H, Herrmann K, Hoskin P, Huguet J, Jereczek-Fossa BA, Jones R, Kamat AM, Khoo V, Kiltie AE, Krege S, Ladoire S, Lara PC, Leliveld A, Linares-Espinós E, Løgager V, Lorch A, Loriot Y, Meijer R, Mir MC, Moschini M, Mostafid H, Müller AC, Müller CR, N'Dow J, Necchi A, Neuzillet Y, Oddens JR, Oldenburg J, Osanto S, J G Oyen W, Pacheco-Figueiredo L, Pappot H, Patel MI, Pieters BR, Plass K, Remzi M, Retz M, Richenberg J, Rink M, Roghmann F, Rosenberg JE, Rouprêt M, Rouvière O, Salembier C, Salminen A, Sargos P, Sengupta S, Sherif A, Smeenk RJ, Smits A, Stenzl A, Thalmann GN, Tombal B, Turkbey B, Lauridsen SV, Valdagni R, Der Heijden AGV, Van Poppel H, Vartolomei MD, Veskimäe E, Vilaseca A, Rivera FAV, Wiegel T, Wiklund P, Williams A, Zigeuner R, Horwich A., UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, UCL - (SLuc) Service d'urologie, Witjes, Ja, Babjuk, M, Bellmunt, J, Bruins, Hm, De Reijke, Tm, De Santis, M, Gillessen, S, James, N, Maclennan, S, Palou, J, Powles, T, Ribal, Mj, Shariat, Sf, Van der Kwast, T, Xylinas, E, Agarwal, N, Arends, T, Bamias, A, Birtle, A, Black, Pc, Bochner, Bh, Bolla, M, Boormans, Jl, Bossi, A, Briganti, A, Brummelhuis, I, Burger, M, Castellano, D, Cathomas, R, Chiti, A, Choudhury, A, Comperat, E, Crabb, S, Culine, S, De Bari, B, De Blok, W, De Visschere, Pjl, Decaestecker, K, Dimitropoulos, K, Dominguez-Escrig, Jl, Fanti, S, Fonteyne, V, Frydenberg, M, Futterer, Jj, Gakis, G, Geavlete, B, Gontero, P, Grubmuller, B, Hafeez, S, Hansel, De, Hartmann, A, Hayne, D, Henry, Am, Hernandez, V, Herr, H, Herrmann, K, Hoskin, P, Huguet, J, Jereczek-Fossa, Ba, Jones, R, Kamat, Am, Khoo, V, Kiltie, Ae, Krege, S, Ladoire, S, Lara, Pc, Leliveld, A, Linares-Espinos, E, Logager, V, Lorch, A, Loriot, Y, Meijer, R, Mir, Mc, Moschini, M, Mostafid, H, Muller, Ac, Muller, Cr, N'Dow, J, Necchi, A, Neuzillet, Y, Oddens, Jr, Oldenburg, J, Osanto, S, Oyen, Wjg, Pacheco-Figueiredo, L, Pappot, H, Patel, Mi, Pieters, Br, Plass, K, Remzi, M, Retz, M, Richenberg, J, Rink, M, Roghmann, F, Rosenberg, Je, Roupret, M, Rouviere, O, Salembier, C, Salminen, A, Sargos, P, Sengupta, S, Sherif, A, Smeenk, Rj, Smits, A, Stenzl, A, Thalmann, Gn, Tombal, B, Turkbey, B, Lauridsen, Sv, Valdagni, R, Van der Heijden, Ag, Van Poppel, H, Vartolomei, Md, Veskimae, E, Vilaseca, A, Rivera, Fav, Wiegel, T, Wiklund, P, Williams, A, Zigeuner, R, and Horwich, A
- Subjects
Treatment ,Consensus ,Follow-up ,education ,Bladder cancer ,Diagnosis ,Consensu ,Delphi ,Diagnosi - Abstract
Background: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial.Objective: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management.Design: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts prior to voting during a consensus conference.Setting: Online Delphi survey and consensus conference.Participants: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management.Outcome measurements and statistical analysis: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), and 7-9 (agree). A priori (level 1) consensus was defined as >= 70% agreement and
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- 2020
11. FOXP3 expression in cancer cells and anthracyclines efficacy in patients with primary breast cancer treated with adjuvant chemotherapy in the phase III UNICANCER-PACS 01 trial
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Ladoire, S., Mignot, G., Dalban, C., Chevriaux, A., Arnould, L., Rébé, C., Apetoh, L., Boidot, R., Penault-Llorca, F., Fumoleau, P., Roché, H., Spielmann, M., Levy, C., Lortholary, A., Eichler, F., Mesleard, C., Bonnetain, F., and Ghiringhelli, F.
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- 2012
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12. Tratamiento del cáncer de mama infiltrante localizado: nuevos desafíos
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Jankowski, C., primary, Fumet, J.-D., additional, Kaderbhai, C., additional, Peignaux, K., additional, Arnould, L., additional, Ladoire, S., additional, and Coutant, C., additional
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- 2021
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13. 670P Cabozantinib associated with concomitant radiotherapy or a bone targeted agent (multimodal approach, results from the CABOREAL study post-hoc analysis)
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Gross-Goupil, M., primary, Fléchon, A., additional, Mourey, L., additional, Topart, D., additional, Gravis, G., additional, Oudard, S.M., additional, Tourani, J-M., additional, Geoffrois, L., additional, Meriaux, E., additional, Thiery-Vuillemin, A., additional, Barthelemy, P., additional, Ladoire, S., additional, Laguerre, B., additional, Zara, L., additional, Perrot, V., additional, Escudier, B., additional, and Albiges, L., additional
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- 2021
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14. 697P Impact of β-blockers (BB) on outcomes of metastatic renal cell carcinoma (mRCC) patients treated with nivolumab (N)
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Alves Costa Silva, C., primary, Derosa, L., additional, Dalban, C., additional, Colomba, E., additional, Negrier, S., additional, Chevreau, C.M., additional, Gravis, G., additional, Oudard, S.M., additional, Laguerre, B., additional, Barthelemy, P., additional, Borchiellini, D., additional, Gross-Goupil, M., additional, Geoffrois, L., additional, Rolland, F., additional, Thiery-Vuillemin, A., additional, Joly, F., additional, Ladoire, S., additional, Tantot, F., additional, Escudier, B., additional, and Albiges, L., additional
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- 2021
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15. 657MO Antibiotic (ATB) therapy and outcome from nivolumab (N) in metastatic renal cell carcinoma (mRCC) patients (pts): Results of the GETUG-AFU 26 NIVOREN multicentric phase II study
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Derosa, L., primary, Alves Costa Silva, C., additional, Dalban, C., additional, Colomba, E., additional, Negrier, S., additional, Chevreau, C.M., additional, Gravis, G., additional, Oudard, S.M., additional, Laguerre, B., additional, Barthelemy, P., additional, Borchiellini, D., additional, Gross-Goupil, M., additional, Geoffrois, L., additional, Rolland, F., additional, Thiery-Vuillemin, A., additional, Joly, F., additional, Ladoire, S., additional, Tantot, F., additional, Escudier, B., additional, and Albiges, L., additional
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- 2021
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16. LBA15 Primary outcome of the phase III SYD985.002/TULIP trial comparing [vic-]trastuzumab duocarmazine to physician’s choice treatment in patients with pre-treated HER2-positive locally advanced or metastatic breast cancer
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Saura Manich, C., primary, O'Shaughnessy, J., additional, Aftimos, P.G., additional, van den Tweel, E., additional, Oesterholt, M., additional, Escrivá-de-Romaní, S.I., additional, Quenel Tueux, N., additional, Tan, T.J., additional, Lim, J.S., additional, Ladoire, S., additional, Armstrong, A., additional, Crook, T., additional, Stradella, A., additional, Bianchi, G., additional, Mulder, R., additional, Koper, N., additional, and Turner, N., additional
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- 2021
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17. 1707P A single G-CSF administration is enough to limit neutropenia in patients treated by eribulin
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Schmitt, A., primary, Reda, M., additional, Macaire, P., additional, Bellio, H., additional, Uwer, L., additional, Ilie, S.M., additional, Lorgis, V., additional, Hennequin, A., additional, Ladoire, S., additional, Rederstorff, E., additional, Fumoleau, P., additional, Isambert, N., additional, Bonnin, N., additional, You, B., additional, Freyer, G., additional, and Desmoulins, I., additional
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- 2021
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18. 165P Pathologic and immunohistochemical prognostic score in residual triple-negative breast cancer after neoadjuvant chemotherapy
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Ilie, S.M., primary, Arnould, L., additional, Briot, N., additional, Desmoulins, I., additional, Hennequin, A., additional, Kaderbhai, C., additional, Bertaut, A., additional, Coutant, C., additional, Causeret, S., additional, Loustalot, C., additional, Ilie, A., additional, Derangere, V., additional, and Ladoire, S., additional
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- 2021
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19. 386MO Trastuzumab duocarmazine versus physician's choice therapy in pre-treated HER2-positive metastatic breast cancer: Final results of the phase III TULIP trial
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Aftimos, P.G., Turner, N., O'Shaughnessy, J., van den Tweel, E., Oesterholt, M., Escrivá-de-Romaní, S., Tueux, N. Quenel, Tan, T.J.Y., Lim, J., Ladoire, S., Armstronh, A.C., Stradella, A., Bianchi, G.V., Colleoni, M.A., Kaczmarek, E., Punie, K., Song, X., Koper, N., and Manich, C. Saura
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- 2023
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20. 255P Prognostic stratification capacity of the CPS+EG scoring system in HER2-low and HER2-zero early breast cancer treated with neoadjuvant chemotherapy
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Roussot, N., Constantin, G., Desmoulins, I., Kaderbhai, C., Hennequin, A., Mayeur, D., Ilie, S.M., Arnould, L., Bertaut, A., Eymard, J-C., Jouannaud, C., Savoye, A.M., Yazbek, G., Allouache, D., Delcambre, C., Hrab, I., Levy, C., Djezzer, C. Segura, Deblock, M., and Ladoire, S.
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- 2023
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21. 736P Residual masses after salvage chemotherapy in men with metastatic seminoma: The Semi-ResMass multicenter retrospective study
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Baciarello, G., Brard, C., Baumert, H., De Giorgi, U.F.F., Flechon, A., Giannatempo, P., Gravis, G., Morelli, F., Pouessel, D., Vincenzi, B., Oing, C., Secondino, S., Ladoire, S., Crouzet, L., Naoun, N., Foulon, S., and Fizazi, K.
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- 2023
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22. Combining immunotherapy and anticancer agents: the right path to achieve cancer cure?
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Apetoh, L., Ladoire, S., Coukos, G., and Ghiringhelli, F.
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- 2015
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23. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
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Klionsky, DJ, Abdel-Aziz, AK, Abdelfatah, S, Abdellatif, M, Abdoli, A, Abel, S, Abeliovich, H, Abildgaard, MH, Abudu, YP, Acevedo-Arozena, A, Adamopoulos, IE, Adeli, K, Adolph, TE, Adornetto, A, Aflaki, E, Agam, G, Agarwal, A, Aggarwal, BB, Agnello, M, Agostinis, P, Agrewala, JN, Agrotis, A, Aguilar, PV, Ahmad, ST, Ahmed, ZM, Ahumada-Castro, U, Aits, S, Aizawa, S, Akkoc, Y, Akoumianaki, T, Akpinar, HA, Al-Abd, AM, Al-Akra, L, Al-Gharaibeh, A, Alaoui-Jamali, MA, Alberti, S, Alcocer-Gómez, E, Alessandri, C, Ali, M, Alim Al-Bari, MA, Aliwaini, S, Alizadeh, J, Almacellas, E, Almasan, A, Alonso, A, Alonso, GD, Altan-Bonnet, N, Altieri, DC, Álvarez, ÉMC, Alves, S, Alves da Costa, C, Alzaharna, MM, Amadio, M, Amantini, C, Amaral, C, Ambrosio, S, Amer, AO, Ammanathan, V, An, Z, Andersen, SU, Andrabi, SA, Andrade-Silva, M, Andres, AM, Angelini, S, Ann, D, Anozie, UC, Ansari, MY, Antas, P, Antebi, A, Antón, Z, Anwar, T, Apetoh, L, Apostolova, N, Araki, T, Araki, Y, Arasaki, K, Araújo, WL, Araya, 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Yuan, S-SF, Yuan, Y, Yuan, Z, Yue, J, Yue, Z, Yun, J, Yung, RL, Zacks, DN, Zaffagnini, G, Zambelli, VO, Zanella, I, Zang, QS, Zanivan, S, Zappavigna, S, Zaragoza, P, Zarbalis, KS, Zarebkohan, A, Zarrouk, A, Zeitlin, SO, Zeng, J, Zeng, J-D, Žerovnik, E, Zhan, L, Zhang, B, Zhang, DD, Zhang, H, Zhang, H-L, Zhang, J, Zhang, J-P, Zhang, KYB, Zhang, LW, Zhang, L, Zhang, M, Zhang, P, Zhang, S, Zhang, W, Zhang, X, Zhang, X-W, Zhang, XD, Zhang, Y, Zhang, Y-D, Zhang, Y-Y, Zhang, Z, Zhao, H, Zhao, L, Zhao, S, Zhao, T, Zhao, X-F, Zhao, Y, Zheng, G, Zheng, K, Zheng, L, Zheng, S, Zheng, X-L, Zheng, Y, Zheng, Z-G, Zhivotovsky, B, Zhong, Q, Zhou, A, Zhou, B, Zhou, C, Zhou, G, Zhou, H, Zhou, J, Zhou, K, Zhou, R, Zhou, X-J, Zhou, Y, Zhou, Z-Y, Zhou, Z, Zhu, B, Zhu, C, Zhu, G-Q, Zhu, H, Zhu, W-G, Zhu, Y, Zhuang, H, Zhuang, X, Zientara-Rytter, K, Zimmermann, CM, Ziviani, E, Zoladek, T, Zong, W-X, Zorov, DB, Zorzano, A, Zou, W, Zou, Z, Zuryn, S, Zwerschke, W, Brand-Saberi, B, Dong, XC, Kenchappa, CS, Lin, Y, Oshima, S, Rong, Y, Sluimer, JC, Stallings, CL, and Tong, C-K
- Abstract
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.
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- 2021
24. Treatment of Metastatic Urothelial Carcinoma After Previous Cisplatin-based Chemotherapy for Localized Disease: A Retrospective Comparison of Different Chemotherapy Regimens
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Do, O.A. Ferris, L.A. Holt, S.K. Ramos, J.D. Harshman, L.C. Plimack, E.R. Crabb, S.J. Pal, S.K. De Giorgi, U. Ladoire, S. Baniel, J. Necchi, A. Vaishampayan, U.N. Bamias, A. Bellmunt, J. Srinivas, S. Dorff, T.B. Galsky, M.D. Yu, E.Y.
- Abstract
Background: Optimal chemotherapy for patients who received cisplatin for localized urothelial carcinoma (UC) and develop metastatic disease is unclear. We compared the efficacy of platinum-based (PBC) versus non–platinum-based (NPBC) first-line chemotherapy for metastasis. Patients and Methods: Data were collected from the Retrospective International Study of Cancers of the Urothelial Tract (RISC), a database of 3024 patients from 28 international academic centers from 2005 to 2012. Patient inclusion criteria included: (1) predominant UC; (2) any primary tumor site; (3) cT2-4, cN0-N2, cM0; (4) prior receipt of perioperative/radiation cisplatin-containing chemotherapy; and (5) receipt of cytotoxic chemotherapy in the first-line metastatic setting. Multivariate Cox proportional hazards models were used to show progression-free survival (PFS) and overall survival (OS) from the first day of chemotherapy for metastatic disease to date of censor. Results: Eligibility criteria was met by 132 patients (n = 74 PBC; n = 58 NPBC). The median OS was 8.13 months (interquartile range, 4.87-16.64 months) and 8.77 months (interquartile range, 4.01-13.49 months) for PBC and NPBC, respectively. Neither OS (hazard ratio [HR], 1.04; 95% confidence interval [CI], 0.64-1.69; P =.87) nor PFS (HR, 0.86; 95% CI, 0.56-1.31; P =.48) differed for PBC versus NPBC. However, for patients who received chemotherapy more than a year after perioperative/radiation chemotherapy, OS was superior for PBC over NPBC (HR, 0.31; 95% CI, 0.10-0.92; P =.03). Conclusions: There is no significant outcome difference between PBC and NPBC in patients with metastatic UC who previously received cisplatin-based chemotherapy for localized disease. However, if over a year has elapsed, return to PBC is associated with superior OS. © 2020 Elsevier Inc.
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- 2021
25. Tendances de prescription de l’hormonothérapie et survie chez les femmes atteintes d’un cancer du sein non métastatique à récepteurs hormonaux positifs traitées par hormonothérapie - Étude sur base de données populationnelle
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Mamguem Kamga, A., primary, Billa, O., additional, Ladoire, S., additional, Poillot, M., additional, Jolimoy, G., additional, Roignot, P., additional, Coutant, C., additional, Desmoulin, I., additional, Maynadie, M., additional, and Dabakuyo-Yonli, S., additional
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- 2021
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26. Nephrectomy after complete response to immune checkpoint inhibitors for Metastatic Renal Cell Carcinoma (mRCC): A surgical challenge allowing favorable oncological outcomes
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Pignot, G., primary, Thiery-Vuillemin, A., additional, Walz, J., additional, Lang, H., additional, Balssa, L., additional, Geoffrois, L., additional, Leblanc, L., additional, Albiges, L., additional, Bensalah, K., additional, Ladoire, S., additional, Bigot, P., additional, Ingels, A., additional, Saldana, C., additional, Roubaud, G., additional, Piechaud, T., additional, Cassuto, O., additional, Klifa, D., additional, Parier, B., additional, Bernhard, J.C., additional, Malouf, G., additional, Gravis, G., additional, and Barthelemy, P., additional
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- 2021
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27. 147P When a single G-CSF administration is better than longer duration: Example in patients treated by eribulin
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Schmitt, A., primary, Reda, M., additional, Macaire, P., additional, Bellio, H., additional, Uwer, L., additional, Ilie, S.M., additional, Lorgis, V., additional, Hennequin, A., additional, Ladoire, S., additional, Rederstorff, E., additional, Fumoleau, P., additional, Isambert, N., additional, Bonnin, N., additional, You, B., additional, Freyer, G., additional, and Desmoulins, I., additional
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- 2021
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28. Human FOXP3 and cancer
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Martin, F, Ladoire, S, Mignot, G, Apetoh, L, and Ghiringhelli, F
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- 2010
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29. Erratum: Impact of contemporary patterns of chemotherapy utilization on survival in patients with advanced cancer of the urinary tract: a Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC) (Annals of Oncology (2018) 29(2) (361–369), (S0923753419350392), (10.1093/annonc/mdx692))
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Bamias A., Tzannis K., Harshman L. C., Crabb S. J., Wong Y. -N., Kumar Pal S., De Giorgi U., Ladoire S., Agarwal N., Yu E. Y., Niegisch G., Necchi A., Sternberg C. N., Srinivas S., Alva A., Vaishampayan U., Cerbone L., Liontos M., Rosenberg J., Powles T., Bellmunt J., Galsky M. D., Bamias, A., Tzannis, K., Harshman, L. C., Crabb, S. J., Wong, Y. -N., Kumar Pal, S., De Giorgi, U., Ladoire, S., Agarwal, N., Yu, E. Y., Niegisch, G., Necchi, A., Sternberg, C. N., Srinivas, S., Alva, A., Vaishampayan, U., Cerbone, L., Liontos, M., Rosenberg, J., Powles, T., Bellmunt, J., and Galsky, M. D.
- Abstract
Ann Oncol 2018; 29: 361–369 (doi: 10.1093/annonc/mdx692) In the original abstract, the sentence “About 1794 patients treated between 2000 and 2013 at 29 centers were analyzed. Median follow-up was 29.1 months.” Has been corrected to: “1794 patients treated between 2000 and 2013 at 29 centers were analyzed. Median follow-up was 29.1 months.” Table 2 has also been corrected as below (the last three lines of numbers have been moved down one line)
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- 2019
30. Corrigendum to ‘EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer—An International Collaborative Multistakeholder Effort Under the Auspices of the EAU-ESMO Guidelines Committees’ [European Urology 77 (2020) 223–250](S0302283819307638)(10.1016/j.eururo.2019.09.035)
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Witjes, J.A. Babjuk, M. Bellmunt, J. Bruins, H.M. De Reijke, T.M. De Santis, M. Gillessen, S. James, N. Maclennan, S. Palou, J. Powles, T. Ribal, M.J. Shariat, S.F. Van Der Kwast, T. Xylinas, E. Agarwal, N. Arends, T. Bamias, A. Birtle, A. Black, P.C. Bochner, B.H. Bolla, M. Boormans, J.L. Bossi, A. Briganti, A. Brummelhuis, I. Burger, M. Castellano, D. Cathomas, R. Chiti, A. Choudhury, A. Compérat, E. Crabb, S. Culine, S. De Bari, B. De Blok, W. De Visschere, P.J.L. Decaestecker, K. Dimitropoulos, K. Dominguez-Escrig, J.L. Fanti, S. Fonteyne, V. Frydenberg, M. Futterer, J.J. Gakis, G. Geavlete, B. Gontero, P. Grubmüller, B. Hafeez, S. Hansel, D.E. Hartmann, A. Hayne, D. Henry, A.M. Hernandez, V. Herr, H. Herrmann, K. Hoskin, P. Huguet, J. Jereczek-Fossa, B.A. Jones, R. Kamat, A.M. Khoo, V. Kiltie, A.E. Krege, S. Ladoire, S. Lara, P.C. Leliveld, A. Linares-Espinós, E. Løgager, V. Lorch, A. Loriot, Y. Meijer, R. Mir, M.C. Moschini, M. Mostafid, H. Müller, A.-C. Müller, C.R. N'Dow, J. Necchi, A. Neuzillet, Y. Oddens, J.R. Oldenburg, J. Osanto, S. Oyen, W.J.G. Pacheco-Figueiredo, L. Pappot, H. Patel, M.I. Pieters, B.R. Plass, K. Remzi, M. Retz, M. Richenberg, J. Rink, M. Roghmann, F. Rosenberg, J.E. Rouprêt, M. Rouvière, O. Salembier, C. Salminen, A. Sargos, P. Sengupta, S. Sherif, A. Smeenk, R.J. Smits, A. Stenzl, A. Thalmann, G.N. Tombal, B. Turkbey, B. Lauridsen, S.V. Valdagni, R. Van Der Heijden, A.G. Van Poppel, H. Vartolomei, M.D. Veskimäe, E. Vilaseca, A. Rivera, F.A.V. Wiegel, T. Wiklund, P. Willemse, P.-P.M. Williams, A. Zigeuner, R. Horwich, A.
- Abstract
The authors regret that a co-author was mistakenly missed from the authorship. The following co-author should have been included in the authorship: Peter-Paul M. Willemse Department of Oncological Urology, University Medical Center, Utrecht Cancer Center, Utrecht, The Netherlands © 2019 European Society of Medical Oncology and European Association of Urology
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- 2020
31. Impact of timing of adjuvant chemotherapy following radical cystectomy for bladder cancer on patient survival
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Grunewald, C.M. Henn, A. Galsky, M.D. Plimack, E.R. Harshman, L.C. Yu, E.Y. Crabb, S.J. Pal, S.K. Alva, A.S. Powles, T. De Giorgi, U. Agarwal, N. Bamias, A. Ladoire, S. Necchi, A. Vaishampayan, U.N. Sternberg, C.N. Bellmunt, J. Baniel, J. Niegisch, G.
- Abstract
Background: Trials of adjuvant chemotherapy following radical cystectomy generally require chemotherapy to start within 90 days postoperatively. However, it is unclear, whether the interval between surgery and start of adjuvant therapy (S-AC-interval) impacts the oncological outcome. Methods: Using the Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC) data base, we identified patients who underwent radical cystectomy for muscle invasive bladder cancer and subsequent adjuvant chemotherapy. Univariate analysis of patient characteristics, surgical factors and tumor characteristics regarding their impact on S-AC-interval was performed using Kruskal-Wallis testing and Fisher's exact test. Analysis of progression-free (PFS) and overall survival (OS) (follow-up time beginning with the start date of adjuvant chemotherapy) was analyzed in relation to S-AC-interval (continuous and dichotomous with a cut-off at 90 days) using Kaplan-Meier method and COX regression analysis. Results: We identified 238 eligible patients (83.5% male, mean age: 63.4 years, 76.1% T3/T4, 66.4% pN+, 14.7% R+, 70.6% urothelial carcinoma, 71% cisplatin-based adjuvant chemotherapy). The majority of patients (n = 207, 87%) started chemotherapy within 90 days after surgery. Median S-AC-interval was 57 days (interquartile range 32.8). S-AC-interval did not have consistent association with any patient/tumor characteristics or surgery related factors (type of surgery, urinary diversion). Survival analysis using continuous S-AC-interval revealed a trend toward an impact of S-AC-interval on OS (hazard ratio 1.004, 95% confidence ratio 0.9997–1.0084, P = 0.071). With regards to PFS, that impact was shown to be statistically significant (hazard ratio 1.004, 95% confidence ratio 1.0003–1.0075, P = 0.032). In multivariate analysis, however, S-AC-interval was negated by tumor and patient related factors (pathological T-stage, N-stage, ECOG performance status). Accounting for eligibility criteria defined in some clinical trials, we extended our analysis dividing S-AC-interval in ≤90 and >90 days. Although we could confirm the trend toward better outcome in patients with a shorter S-AC interval in dichotomous analysis, neither differences in OS nor in PFS reached statistical significance (P = 0.438 and P = 0.056). Conclusions: In a large multi-institutional experience, 87% of patients who received adjuvant chemotherapy received it within the guideline recommended window of 90 days. While it was not possible to determine whether this is the optimal cut-off, early start of adjuvant chemotherapy seems to be reasonable. Regarding prognosis, tumor-related pathological factors abrogated the importance of the S-AC-interval in our analysis. © 2020 Elsevier Inc.
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- 2020
32. EAU-ESMO Consensus Statements on the Management of Advanced and Variant Bladder Cancer-An International Collaborative Multistakeholder Effort†: Under the Auspices of the EAU-ESMO Guidelines Committees
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Witjes JA, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Der Kwast TV, Xylinas E, Agarwal N, Arends T, Bamias A, Birtle A, Black PC, Bochner BH, Bolla M, Boormans JL, Bossi A, Briganti A, Brummelhuis I, Burger M, Castellano D, Cathomas R, Chiti A, Choudhury A, Compérat E, Crabb S, Culine S, De Bari B, De Blok W, J L De Visschere P, Decaestecker K, Dimitropoulos K, Dominguez-Escrig JL, Fanti S, Fonteyne V, Frydenberg M, Futterer JJ, Gakis G, Geavlete B, Gontero P, Grubmüller B, Hafeez S, Hansel DE, Hartmann A, Hayne D, Henry AM, Hernandez V, Herr H, Herrmann K, Hoskin P, Huguet J, Jereczek-Fossa BA, Jones R, Kamat AM, Khoo V, Kiltie AE, Krege S, Ladoire S, Lara PC, Leliveld A, Linares-Espinós E, Løgager V, Lorch A, Loriot Y, Meijer R, Mir MC, Moschini M, Mostafid H, Müller AC, Müller CR, N'Dow J, Necchi A, Neuzillet Y, Oddens JR, Oldenburg J, Osanto S, J G Oyen W, Pacheco-Figueiredo L, Pappot H, Patel MI, Pieters BR, Plass K, Remzi M, Retz M, Richenberg J, Rink M, Roghmann F, Rosenberg JE, Rouprêt M, Rouvière O, Salembier C, Salminen A, Sargos P, Sengupta S, Sherif A, Smeenk RJ, Smits A, Stenzl A, Thalmann GN, Tombal B, Turkbey B, Lauridsen SV, Valdagni R, Van Der Heijden AG, Van Poppel H, Vartolomei MD, Veskimäe E, Vilaseca A, Rivera FAV, Wiegel T, Wiklund P, Williams A, Zigeuner R, Horwich A.
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Consensus ,Follow-up ,education ,Bladder cancer ,Diagnosis ,Treatment ,Delphi - Abstract
Background: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. Objective: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management. Design: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts prior to voting during a consensus conference. Setting: Online Delphi survey and consensus conference. Participants: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management. Outcome measurements and statistical analysis: Statements were ranked by experts according to their level of agreement: 1-3 (disagree), 4-6 (equivocal), and 7-9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus). Results and limitations: Overall, 116 statements were included in the Delphi survey. Of these statements, 33 (28%) achieved level 1 consensus and 49 (42%) achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease, and the evolving role of checkpoint inhibitor therapy in metastatic disease. Conclusions: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time when further evidence is available to guide our approach. Patient summary: This report summarises findings from an international, multistakeholder project organised by the EAU and ESMO. In this project, a steering committee identified areas of bladder cancer management where there is currently no good-quality evidence to guide treatment decisions. From this, they developed a series of proposed statements, 71 of which achieved consensus by a large group of experts in the field of bladder cancer. It is anticipated that these statements will provide further guidance to health care professionals and could help improve patient outcomes until a time when good-quality evidence is available.
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- 2020
33. 712P Primary tumour response in patients treated with nivolumab for metastatic renal cell carcinoma (mRCC): Results of the GETUG-AFU 26 NIVOREN trial
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Courcier, J., primary, Dalban, C., additional, Laguerre, B., additional, Ladoire, S., additional, Barthélémy, P., additional, Oudard, S., additional, Joly, F., additional, Gravis Mescam, G., additional, Chevreau, C.M., additional, Geoffrois, L., additional, Deluche, E., additional, Rolland, F., additional, Topart, D., additional, Culine, S., additional, Négrier, S., additional, Mahammedi, H., additional, Tantot, F., additional, Escudier, B., additional, Flippot, R., additional, and Albiges, L., additional
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- 2020
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34. 722P Cabozantinib in elderly patients: Results from a subanalysis of the CABOREAL study
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Gross-Goupil, M., primary, Fléchon, A., additional, Mourey, L., additional, Topart, D., additional, Gravis, G., additional, Oudard, S., additional, Tourani, J.M., additional, Geoffrois, L., additional, Meriaux, E., additional, Thiery-Vuillemin, A., additional, Barthélémy, P., additional, Ladoire, S., additional, Laguerre, B., additional, Bourouina, R., additional, Perrot, V., additional, Escudier, B., additional, and Albiges, L., additional
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- 2020
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35. 732P Cabozantinib in non-clear cell metastatic renal cell carcinoma and sarcomatoid renal cell carcinoma: Real-world data from the CABOREAL study
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Fléchon, A., primary, Chevreau, C.M., additional, Topart, D., additional, Gravis, G., additional, Oudard, S., additional, Tourani, J.M., additional, Geoffrois, L., additional, Meriaux, E., additional, Thiery-Vuillemin, A., additional, Barthélémy, P., additional, Ladoire, S., additional, Laguerre, B., additional, Bourouina, R., additional, Perrot, V., additional, Escudier, B., additional, Gross-Goupil, M., additional, and Albiges, L., additional
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- 2020
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36. 1878P Health-related quality of life (HRQoL) assessment for patients with advanced renal cell carcinoma (aRCC) treated with a tyrosine kinase inhibitor (TKI) using electronic patient reported outcomes in daily clinical practice: QUANARIE trial
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Mouillet, G., primary, Falcoz, A., additional, Barthélémy, P., additional, Geoffrois, L., additional, Ladoire, S., additional, Eymard, J-C., additional, Plaza, J., additional, Viel, E., additional, Maurina, T., additional, Calcagno, F., additional, Stein, U., additional, Fritzsch, J., additional, Djoumakh, O., additional, Paget-Bailly, S., additional, and Thiery-Vuillemin, A., additional
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- 2020
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37. 1710P International multicentric evaluation of breast cancer patients’ satisfaction and experience with oncology telemedicine visits (TV) during the COVID-19 outbreak
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Bizot, A., primary, Heudel, P-E., additional, Karimi, M., additional, Levy, C., additional, Vanlemmens, L., additional, Uzan, C., additional, Deluche, E., additional, Genet, D., additional, Saghatchian, M., additional, Giacchetti, S., additional, Grenier, J., additional, Patsouris, A., additional, Dieras, V.C., additional, Pierga, J-Y., additional, Petit, T., additional, Ladoire, S., additional, Jacot, W., additional, Delaloge, S., additional, Lambertini, M., additional, and Pistilli, B., additional
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- 2020
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38. Nephrectomy after complete response to immune checkpoint inhibitors for metastatic Renal Cell Carcinoma (mRCC): A new surgical challenge?
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Pignot, G., primary, Thiery-Vuillemin, A., additional, Walz, J., additional, Lang, H., additional, Werle, P., additional, Balssa, L., additional, Geoffrois, L., additional, Leblanc, L., additional, Albigès, L., additional, Di Nunno, V., additional, Bensalah, K., additional, Ladoire, S., additional, Gravis, G., additional, and Barthélémy, P., additional
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- 2020
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39. Étude des performances de la TEP-TDM au 18F-FDG dans les premières suspicions de récidive chez les femmes atteintes d’un adénocarcinome lobulaire du sein
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Bonnin, D., primary, Ladoire, S., additional, Briot, N., additional, Bertaut, A., additional, Drouet, C., additional, Silva, Y.E., additional, Nodari, G., additional, Cochet, A., additional, and Alberini, J.L., additional
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- 2020
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40. ADHERENCE TO ORAL ANTICANCER THERAPIES IN A CLINICAL CANCER CENTRE
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De Gregori, J., primary, Coudert, B., additional, Desmoulins, I., additional, Favier, L., additional, Isambert, N., additional, Zanetta, S., additional, Ghiringhelli, F., additional, Vincent, J., additional, Ladoire, S., additional, Hennequin, A., additional, Lagrange, A., additional, Hervieu, A., additional, Di Martino, C., additional, Gallet, M., additional, Quipourt, V., additional, Lefevre, L.Bengrine, additional, and Schmitt, A., additional
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- 2019
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41. Impact of contemporary patterns of chemotherapy utilization on survival in patients with advanced cancer of the urinary tract: a Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC)
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Bamias, A., primary, Tzannis, K., additional, Harshman, L.C., additional, Crabb, S.J., additional, Wong, Y.-N., additional, Kumar Pal, S., additional, De Giorgi, U., additional, Ladoire, S., additional, Agarwal, N., additional, Yu, E.Y., additional, Niegisch, G., additional, Necchi, A., additional, Sternberg, C.N., additional, Srinivas, S., additional, Alva, A., additional, Vaishampayan, U., additional, Cerbone, L., additional, Liontos, M., additional, Rosenberg, J., additional, Powles, T., additional, Bellmunt, J., additional, and Galsky, M.D., additional
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- 2019
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42. Emergence of ESR1 mutation in cell-free DNA during first line aromatase inhibitor and palbociclib: An exploratory analysis of the PADA-1 trial
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Bidard, F.-C., primary, Callens, C., additional, Pistilli, B., additional, Dalenc, F., additional, de La Motte Rouge, T., additional, Sabatier, R., additional, Frenel, J.-S., additional, Ladoire, S., additional, Dubot, C., additional, Ferrero, J.-M., additional, Clatot, F., additional, Nierges, D., additional, Everhard, S., additional, Lemonnier, J., additional, Bieche, I., additional, Pradines, A., additional, Pierga, J.-Y., additional, Berger, F., additional, Bachelot, T., additional, and Delaloge, S., additional
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- 2019
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43. Impact of corticosteroids on nivolumab activity in metastatic clear cell renal cell carcinoma
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Lefort, F., primary, Dalban, C., additional, Gross-Goupil, M., additional, Laguerre, B., additional, Barthelemy, P., additional, Sarradin, V., additional, Chanez, B., additional, Negrier, S., additional, Geoffrois, L., additional, Gillon, P., additional, De Vries, M., additional, Ladoire, S., additional, Bolognini, C., additional, Laramas, M., additional, Priou, F., additional, Oudard, S., additional, Chabot, S., additional, Tantot, F., additional, Escudier, B., additional, and Albiges, L., additional
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- 2019
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44. Response to neoadjuvant chemotherapy in HER2 non-overexpressing breast cancer subtypes
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Ilie, S.M., primary, Desmoulins, I., additional, Hennequin, A., additional, Courèche-Guillaume, K., additional, Arnould, L., additional, Nathalie, B., additional, Bertaut, A., additional, and Ladoire, S., additional
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- 2019
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45. Metastatic cancer whole-exome sequencing in daily practice
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Réda, M., primary, Richard, C., additional, Niogret, J., additional, Fumet, J.-D., additional, Bertaut, A., additional, Blanc, J., additional, Truntzer, C., additional, Desmoulins, I., additional, Ladoire, S., additional, Bengrine-Lefevre, L., additional, Isambert, N., additional, Hervieu, A., additional, Lepage, C., additional, Foucher, P., additional, Borg, C., additional, Arnould, L., additional, Nambot, S., additional, Faivre, L., additional, Boidot, R., additional, and Ghiringhelli, F., additional
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- 2019
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46. Prise en charge des cancers solides et des hémopathies malignes du sujet âgé : l'oncogériatrie, une discipline en devenir. Seconde partie : traitement des cancers solides (partie 2) et des hémopathies malignes du sujet âgé
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Ladoire, S., Ghiringhelli, F., Manckoundia, P., Casasnovas, R.O., Solary, E., Besancenot, J.F., and Pfitzenmeyer, P.
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- 2005
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47. Prise en charge des cancers solides et des hémopathies malignes du sujet âgé : l’oncogériatrie une discipline en devenir: Première partie : l’évaluation gériatrique et la prise en charge des cancers solides
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Ghiringhelli, F., Ladoire, S., Manckoundia, P., Chauffert, B., Solary, E., Besancenot, J.F., and Pfitzenmeyer, P.
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- 2005
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48. EAU–ESMO consensus statements on the management of advanced and variant bladder cancer—an international collaborative multi-stakeholder effort: under the auspices of the EAU and ESMO Guidelines Committees
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Horwich, A. Babjuk, M. Bellmunt, J. Bruins, H.M. De Reijke, T.M. De Santis, M. Gillessen, S. James, N. Maclennan, S. Palou, J. Powles, T. Ribal, M.J. Shariat, S.F. Van Der Kwast, T. Xylinas, E. Agarwal, N. Arends, T. Bamias, A. Birtle, A. Black, P.C. Bochner, B.H. Bolla, M. Boormans, J.L. Bossi, A. Briganti, A. Brummelhuis, I. Burger, M. Castellano, D. Cathomas, R. Chiti, A. Choudhury, A. Compérat, E. Crabb, S. Culine, S. De Bari, B. DeBlok, W. De Visschere, P.J.L. Decaestecker, K. Dimitropoulos, K. Dominguez-Escrig, J.L. Fanti, S. Fonteyne, V. Frydenberg, M. Futterer, J.J. Gakis, G. Geavlete, B. Gontero, P. Grubmüller, B. Hafeez, S. Hansel, D.E. Hartmann, A. Hayne, D. Henry, A.M. Hernandez, V. Herr, H. Herrmann, K. Hoskin, P. Huguet, J. Jereczek-Fossa, B.A. Jones, R. Kamat, A.M. Khoo, V. Kiltie, A.E. Krege, S. Ladoire, S. Lara, P.C. Leliveld, A. Linares-Espinós, E. Løgager, V. Lorch, A. Loriot, Y. Meijer, R. Carmen Mir, M. Moschini, M. Mostafid, H. Müller, A.-C. Müller, C.R. N'Dow, J. Necchi, A. Neuzillet, Y. Oddens, J.R. Oldenburg, J. Osanto, S. Oyen, W.J.G. Pacheco-Figueiredo, L. Pappot, H. Patel, M.I. Pieters, B.R. Plass, K. Remzi, M. Retz, M. Richenberg, J. Rink, M. Roghmann, F. Rosenberg, J.E. Rouprêt, M. Rouvière, O. Salembier, C. Salminen, A. Sargos, P. Sengupta, S. Sherif, A. Smeenk, R.J. Smits, A. Stenzl, A. Thalmann, G.N. Tombal, B. Turkbey, B. Vahr Lauridsen, S. Valdagni, R. Van Der Heijden, A.G. Van Poppel, H. Vartolomei, M.D. Veskimäe, E. Vilaseca, A. Vives Rivera, F.A. Wiegel, T. Wiklund, P. Williams, A. Zigeuner, R. Witjes, J.A.
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education - Abstract
Background: Although guidelines exist for advanced and variant bladder cancer management, evidence is limited/conflicting in some areas and the optimal approach remains controversial. Objective: To bring together a large multidisciplinary group of experts to develop consensus statements on controversial topics in bladder cancer management. Design: A steering committee compiled proposed statements regarding advanced and variant bladder cancer management which were assessed by 113 experts in a Delphi survey. Statements not reaching consensus were reviewed; those prioritised were revised by a panel of 45 experts before voting during a consensus conference. Setting: Online Delphi survey and consensus conference. Participants: The European Association of Urology (EAU), the European Society for Medical Oncology (ESMO), experts in bladder cancer management. Outcome measurements and statistical analysis: Statements were ranked by experts according to their level of agreement: 1–3 (disagree), 4–6 (equivocal), 7–9 (agree). A priori (level 1) consensus was defined as ≥70% agreement and ≤15% disagreement, or vice versa. In the Delphi survey, a second analysis was restricted to stakeholder group(s) considered to have adequate expertise relating to each statement (to achieve level 2 consensus). Results and limitations: Overall, 116 statements were included in the Delphi survey. Of these, 33 (28%) statements achieved level 1 consensus and 49 (42%) statements achieved level 1 or 2 consensus. At the consensus conference, 22 of 27 (81%) statements achieved consensus. These consensus statements provide further guidance across a broad range of topics, including the management of variant histologies, the role/limitations of prognostic biomarkers in clinical decision making, bladder preservation strategies, modern radiotherapy techniques, the management of oligometastatic disease and the evolving role of checkpoint inhibitor therapy in metastatic disease. Conclusions: These consensus statements provide further guidance on controversial topics in advanced and variant bladder cancer management until a time where further evidence is available to guide our approach. © 2019 European Society for Medical Oncology
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- 2019
49. The Impact of Cisplatin- or Non-Cisplatin-Containing Chemotherapy on Long-Term and Conditional Survival of Patients with Advanced Urinary Tract Cancer
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Bamias, A. Tzannis, K. Bamia, C. Harshman, L.C. Crabb, S. Plimack, E.R. Pal, S. De Giorgi, U. Ladoire, S. Theodore, C. Agarwal, N. Yu, E.Y. Niegisch, G. Sternberg, C.N. Srinivas, S. Vaishampayan, U. Necchi, A. Liontos, M. Rosenberg, J.E. Powles, T. Bellmunt, J. Galsky, M.D.
- Abstract
Background: The impact of cisplatin use on long-term survival of unselected patients with advanced urinary tract cancer (aUTC) has not been adequately investigated. We used a multinational database to study long-term survival and the impact of treatment type in unselected patients with aUTC. Materials and Methods: A total of 1,333 patients with aUTC (cT4bN0M0, cTanyN+M0, cTanyNanyM+), transitional-cell, squamous, or adenocarcinoma histology who received systemic chemotherapy and had available survival data were selected. Long-term survival was defined as alive at 3 years following initiation of first-line chemotherapy. Conditional overall survival (COS) analysis was employed to study change in prognosis given time survived from initiation of first-line chemotherapy. Results: Median follow-up was 31.7 months. The combination of cisplatin use and cisplatin eligibility accurately predicted long-term survival. Eligible patients treated with cisplatin conferred a 31.6% probability of 3-year survival (95% confidence interval [CI]: 25.1–38.3), and 2-year COS for patients surviving 3 years after initiation of cisplatin-based chemotherapy was 83% (95% CI: 59.7–93.5). The respective probabilities for patients who were ineligible for cisplatin or not treated with cisplatin despite eligibility were 14% (95% CI: 10.8–17.6) and 49.3% (95% CI: 28.2–67.4). Two-year COS remained significantly different between these two groups up to 3 years after chemotherapy initiation. Conclusion: Cisplatin-based therapy was associated with the highest likelihood of long-term survival in patients with aUTC and should be used in patients who fulfill the established eligibility criteria. Novel therapies are necessary to increase long-term survival in cisplatin-ineligible patients. Implications for Practice: Long-term, disease-free survival is possible in one in four eligible-for-cisplatin patients with advanced urinary tract cancer (aUTC) treated with cisplatin-based combination chemotherapy. Therefore, deviations from eligibility criteria should be avoided. Consolidation surgery should be considered in responders. These data provide benchmarks for the study of novel therapies in aUTC. © AlphaMed Press 2019
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- 2019
50. Lack of Effectiveness of Postchemotherapy Lymphadenectomy in Bladder Cancer Patients with Clinical Evidence of Metastatic Pelvic or Retroperitoneal Lymph Nodes Only: A Propensity Score-based Analysis
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Necchi, A. Mariani, L. Lo Vullo, S. Yu, E.Y. Woods, M.E. Wong, Y.-N. Harshman, L.C. Alva, A. Sternberg, C.N. Bamias, A. Grivas, P. Koshkin, V.S. Roghmann, F. Dobruch, J. Eigl, B.J. Nappi, L. Milowsky, M.I. Niegisch, G. Pal, S.K. De Giorgi, U. Recine, F. Vaishampayan, U. Berthold, D.D. Bowles, D.W. Baniel, J. Theodore, C. Ladoire, S. Srinivas, S. Agarwal, N. Crabb, S. Sridhar, S. Golshayan, A.-R. Ohlmann, C. Xylinas, E. Powles, T. Rosenberg, J.E. Bellmunt, J. van Rhijn, B. Galsky, M.D. Hendricksen, K.
- Abstract
Background: Limited data is available on the role, and extent of, postchemotherapy lymphadenectomy (PC-LND) in patients with clinical evidence of pelvic (cN1–3) or retroperitoneal (RP) lymph node spread from urothelial bladder carcinoma. Objective: To compare the outcomes of operated versus nonoperated patients after first-line chemotherapy. Design, setting, and participants: Data from 34 centers was collected, totaling 522 patients, treated between January 2000 and June 2015. Criteria for patient selection were the following: bladder primary tumor, lymph node metastases (pelvic ± RP) only, first-line platinum-based chemotherapy given. Intervention: LND (with cystectomy) versus observation after first-line chemotherapy for metastatic urothelial bladder carcinoma. Outcome measures and statistical analysis: Overall survival (OS) was the primary endpoint. Multiple propensity score techniques were adopted, including 1:1 propensity score matching and inverse probability of treatment weighting. Additionally, the inverse probability of treatment weighting analysis was performed with the inclusion of the covariates, that is, with doubly robust estimation. Results and limitations: Overall, 242 (46.4%) patients received PC-LND and 280 (53.6%) observation after chemotherapy. There were 177 (33.9%) and 345 (66.1%) patients with either RP or pelvic LND only, respectively. Doubly robust estimation-adjusted comparison was not significant for improved OS for PC-LND (hazard ratio [HR]: 0.86, 95% confidence interval [CI]: 0.56–1.31, p = 0.479), confirmed by matched analysis (HR: 0.91, 95% CI: 0.60–1.36, p = 0.628). This was also observed in the RP subgroup (HR: 1.12, 95% CI: 0.68–1.84). The retrospective nature of the data and the heterogeneous patient population were the major limitations. Conclusions: Although there were substantial differences between the two groups, after accounting for major confounders we report a nonsignificant OS difference with PC-LND compared with observation only. These findings may be hypothesis-generating for future prospective trials. Patient summary: We found no differences in survival by adding postchemotherapy lymphadenectomy in patients with pelvic or retroperitoneal lymph node metastatic bladder cancer. The indication to perform postchemotherapy lymphadenectomy in the most suitable patients requires additional studies. © 2017 European Association of Urology In contemporary cohorts of patients with metastatic pelvic or retroperitoneal lymph nodes from bladder cancer, we found no survival benefit from postchemotherapy surgery versus observation in a retrospective study. Performing postchemotherapy lymphadenectomy remains investigational in patients with metastatic bladder cancer. © 2017 European Association of Urology
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- 2019
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