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14. Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

Author

Ladefoged Ole, Vogel Ulla, Jensen Keld, Møller Peter, Jacobsen Nicklas, Loft Steffen, and Wallin Håkan

Subjects
Toxicology. Poisons, RA1190-1270, Industrial hygiene. Industrial welfare, HD7260-7780.8
Abstract

Abstract Background The toxic and inflammatory potential of 5 different types of nanoparticles were studied in a sensitive model for pulmonary effects in apolipoprotein E knockout mice (ApoE-/-). We studied the effects instillation or inhalation Printex 90 of carbon black (CB) and compared CB instillation in ApoE-/- and C57 mice. Three and 24 h after pulmonary exposure, inflammation was assessed by mRNA levels of cytokines in lung tissue, cell composition, genotoxicity, protein and lactate dehydrogenase activity in broncho-alveolar lavage (BAL) fluid. Results Firstly, we found that intratracheal instillation of CB caused far more pulmonary toxicity in ApoE-/- mice than in C57 mice. Secondly, we showed that instillation of CB was more toxic than inhalation of a presumed similar dose with respect to inflammation in the lungs of ApoE-/- mice. Thirdly, we compared effects of instillation in ApoE-/- mice of three carbonaceous particles; CB, fullerenes C60 (C60) and single walled carbon nanotubes (SWCNT) as well as gold particles and quantum dots (QDs). Characterization of the instillation media revealed that all particles were delivered as agglomerates and aggregates. Significant increases in Il-6, Mip-2 and Mcp-1 mRNA were detected in lung tissue, 3 h and 24 h following instillation of SWCNT, CB and QDs. DNA damage in BAL cells, the fraction of neutrophils in BAL cells and protein in BAL fluid increased statistically significantly. Gold and C60 particles caused much weaker inflammatory responses. Conclusion Our data suggest that ApoE-/- model is sensitive for evaluating particle induced inflammation. Overall QDs had greatest effects followed by CB and SWCNT with C60 and gold being least inflammatory and DNA-damaging. However the gold was used at a much lower mass dose than the other particles. The strong effects of QDs were likely due to Cd release. The surface area of the instilled dose correlated well the inflammatory response for low toxicity particles.

Published
2009
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21. Gravid og hvad så?

Author

Mikkelsen, A. B., Schaumburg, I., and Ladefoged, Ole

Published
2003

25. Helhedssyn på fisk og fiskevarer

Author

Andersen, Jens Kirk, Andersen, Niels Lyhne, Bertelsen, Ulla, Bjergskov, Thyra, Brandt, Anne-Merete, Brix, Rikke, Büchert, Arne, Cederberg, Tommy Licht, Christensen, Tue, Dalgaard, Maiken, Duedahl-Olesen, Lene, Fabech, Bente, Fromberg, Arvid, Hansen, Hanne Kyhnau, Hansen, Mette B., Hartkopp, Henrik Bach, Hass, Ulla, Biltoft-Jensen, Anja Pia, Jørgensen, Kevin, Koch, Bente, Ladefoged, Ole, Lam, Henrik Rye, Larsen, John Christian, Leth, Torben, Licht, Dorthe, Ovesen, Lars, Pedersen, Agnes N., Rasmussen, Lone Banke, Rasmussen, Esben Egede, Schnipper, Anette, Sporon-Fiedler, Charlotte, Søndergaard, Camilla Bjerre, Trolle, Ellen, and Vedsted, Nicolai

Published
2003

26. Children and the unborn child, Exposure and susceptibility to chemical substances – an evaluation:Report to the Danish Environmental Protection Agency

Author

Nielsen, Elsa, Thorup, I., Schnipper, Anette, Hass, Ulla, Meyer, Otto A., Ladefoged, Ole, Larsen, John Christian, Østergaard, G., Sørensen, T. L., and Larsen, P. B.

Abstract

Children are at risk of exposure to a lot of high-production-volume synthetic chemical substances which have been introduced into the market within the past 50 years; these chemical substances are used widely in consumer products and are dispersed in the environment. Children as well as the unborn child have in some cases appeared to be uniquely vulnerable to chemical toxicants because of their biological growth and development. Furthermore, children may be more heavily exposed than adults to certain chemicals and pollutants in the environment. This report summarises and discusses the current knowledge about the biological susceptibility and exposure of chemical substances to children during the embryonic, foetal, and postnatal periods.

Published
2001

28. Ladefoged, Ole

Author

Ladefoged, Ole and Ladefoged, Ole

Published
2012

29. Scientific Committee on Health and Environmental Risks opinion on: Voluntary Risk Assessment Report on Lead and its compounds, Environmental Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 27th plenary of 13 January 2009, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2009

30. Scientific Committee on Health and Environmental Risks opinion on: The need for non- human primates in biomedical research, production and testing of products and devices

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 27th plenary of 13 January 2009, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, There is also a popularised layman language version of the opinion, Non Animal Testing, info:eu-repo/semantics/published

Published
2009

31. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on nickel and its compounds, Environmental Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 27th plenary of 13 January 2009, 16p, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2009

32. SCCP (Scientific Committee on Consumer Products) / SCHER (Scientific Committee on Health& Environment Risks) / SCENIHR (Scientific Committee on Emerging and Newly- Identified Health Risks) opinion on: Risk assessment methodologies and approaches for genotoxic and carcinogenic substances

Author

Autrup, Herman, Bridges, James, Degen, Gisela H., Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Mangelsdorf, Inge, Platzek, Thomas, Rydzynski, Konrad, Sanner, Tore, Steenhout, Anne, Viluksela, Matti, Anundi, I., Knaap, A., Andrae, U., Calow, Peter, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Nuti, Marco, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Autrup, Herman, Bridges, James, Degen, Gisela H., Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Mangelsdorf, Inge, Platzek, Thomas, Rydzynski, Konrad, Sanner, Tore, Steenhout, Anne, Viluksela, Matti, Anundi, I., Knaap, A., Andrae, U., Calow, Peter, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Nuti, Marco, Tarazona, Jose, Testai, Emanuela, and Vighi, Marco

Abstract

Adopted by the SCHER during the 27th plenary of 13 January 2009 ,by SCENIHR ib 19 Jan2009; by SCCP on 21 Jan 2009. 47pp., http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, http://ec.europa.eu/health/archive/ph_risk/committees/04_scher/docs/scher_o_113.pdf, Others, info:eu-repo/semantics/published

Published
2009

33. Scientific Committee on Health and Environmental Risks opinion on: Voluntary Risk Assessment Report on lead and lead compounds, Human Health Part

Author

Dekant, Wolfgang, Steenhout, Anne, Autrup, Herman, Calow, Peter, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Dekant, Wolfgang, Steenhout, Anne, Autrup, Herman, Calow, Peter, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER by written procedure on 12 February 2009; 7 p, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, http://ec.europa.eu/health/archive/ph_risk/committees/04_scher/docs/scher_o_114.pdf, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2009

34. Scientific Committee on Health and Environmental Risks opinion on: Voluntary Risk Assessment Report on Copper and its compounds, Environmental Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Members of SCHERAdopted by the SCHER by written procedure on 12 February 2009, 15p.Chemicals under Reg.793/93, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, info:eu-repo/semantics/published

Published
2009

35. Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

Author

Jacobsen, Nicklas Raun, Møller, Peter, Jensen, Keld Alstrup, Vogel, Ulla, Ladefoged, Ole, Loft, Steffen, Wallin, Erik Håkan Richard, Jacobsen, Nicklas Raun, Møller, Peter, Jensen, Keld Alstrup, Vogel, Ulla, Ladefoged, Ole, Loft, Steffen, and Wallin, Erik Håkan Richard

Abstract

Udgivelsesdato: 2009-Jan-12, BACKGROUND: The toxic and inflammatory potential of 5 different types of nanoparticles were studied in a sensitive model for pulmonary effects in apolipoprotein E knockout mice (ApoE-/-). We studied the effects instillation or inhalation Printex 90 of carbon black (CB) and compared CB instillation in ApoE-/- and C57 mice. Three and 24 h after pulmonary exposure, inflammation was assessed by mRNA levels of cytokines in lung tissue, cell composition, genotoxicity, protein and lactate dehydrogenase activity in broncho-alveolar lavage (BAL) fluid. RESULTS: Firstly, we found that intratracheal instillation of CB caused far more pulmonary toxicity in ApoE-/- mice than in C57 mice. Secondly, we showed that instillation of CB was more toxic than inhalation of a presumed similar dose with respect to inflammation in the lungs of ApoE-/- mice. Thirdly, we compared effects of instillation in ApoE-/- mice of three carbonaceous particles; CB, fullerenes C60 (C60) and single walled carbon nanotubes (SWCNT) as well as gold particles and quantum dots (QDs). Characterization of the instillation media revealed that all particles were delivered as agglomerates and aggregates. Significant increases in Il-6, Mip-2 and Mcp-1 mRNA were detected in lung tissue, 3 h and 24 h following instillation of SWCNT, CB and QDs. DNA damage in BAL cells, the fraction of neutrophils in BAL cells and protein in BAL fluid increased statistically significantly. Gold and C60 particles caused much weaker inflammatory responses. CONCLUSIONS: Our data suggest that ApoE-/- model is sensitive for evaluating particle induced inflammation. Overall QDs had greatest effects followed by CB and SWCNT with C60 and gold being least inflammatory and DNA-damaging. However the gold was used at a much lower mass dose than the other particles. The strong effects of QDs were likely due to Cd release. The surface area of the instilled dose correlated well the inflammatory response for low toxicity particles.

Published
2009

36. Lung inflammation and genotoxicity following pulmonary exposure to nanoparticles in ApoE-/- mice

Author

Raun Jacobsen, Nicklas, Møller, Peter, Alstrup Jensen, Keld, Vogel, Ulla Birgitte, Ladefoged, Ole, Loft, Steffen, Wallin, Håkan, Raun Jacobsen, Nicklas, Møller, Peter, Alstrup Jensen, Keld, Vogel, Ulla Birgitte, Ladefoged, Ole, Loft, Steffen, and Wallin, Håkan

Abstract

Background: The toxic and inflammatory potential of 5 different types of nanoparticles were studied in a sensitive model for pulmonary effects in apolipoprotein E knockout mice (ApoE(-/-)). We studied the effects instillation or inhalation Printex 90 of carbon black ( CB) and compared CB instillation in ApoE-/- and C57 mice. Three and 24 h after pulmonary exposure, inflammation was assessed by mRNA levels of cytokines in lung tissue, cell composition, genotoxicity, protein and lactate dehydrogenase activity in broncho-alveolar lavage (BAL) fluid. Results: Firstly, we found that intratracheal instillation of CB caused far more pulmonary toxicity in ApoE-/- mice than in C57 mice. Secondly, we showed that instillation of CB was more toxic than inhalation of a presumed similar dose with respect to inflammation in the lungs of ApoE(-/-) mice. Thirdly, we compared effects of instillation in ApoE-/- mice of three carbonaceous particles; CB, fullerenes C-60 (C-60) and single walled carbon nanotubes (SWCNT) as well as gold particles and quantum dots (QDs). Characterization of the instillation media revealed that all particles were delivered as agglomerates and aggregates. Significant increases in Il-6, Mip-2 and Mcp-1 mRNA were detected in lung tissue, 3 h and 24 h following instillation of SWCNT, CB and QDs. DNA damage in BAL cells, the fraction of neutrophils in BAL cells and protein in BAL fluid increased statistically significantly. Gold and C-60 particles caused much weaker inflammatory responses. Conclusion: Our data suggest that ApoE(-/-) model is sensitive for evaluating particle induced inflammation. Overall QDs had greatest effects followed by CB and SWCNT with C-60 and gold being least inflammatory and DNA-damaging. However the gold was used at a much lower mass dose than the other particles. The strong effects of QDs were likely due to Cd release. The surface area of the instilled dose correlated well the inflammatory response for low toxicity particles.

Published
2009

37. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on 2,4-dinitrotoluene Human Health Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 21st plenary of 15 January 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

38. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on Diphenylamine Human Health Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 21st plenary of 15 January 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

39. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on 2-furaldehyde (furfural) Environmental Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 21st plenary of 15 January 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

40. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on HEXABROMOCYCLODODECANE (HBCDD) Human Health Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 21st plenary of 15 January 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

41. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on N-CYCLOHEXYLBENZOTHIAZOL-2-SULFENAMIDE Human Health Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 21st plenary of 15 January 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

42. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on sodium hypochlorite, Human Health Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 21st plenary of 15 January 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

43. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on 1,3,4,6,7,8-HEXAHYDRO- 4,6,6,7,8,8-HEXAMETHYLCYCLOPENTA-γ-2-BENZOPYRAN (HHCB) Human Health Part (indirect exposure)

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 23rd plenary of 06 May 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

44. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on 4-tert- Butylbenzoic acid (PTBBA) Environmental Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 23rd plenary of 06 May 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

45. Scientific Committee on Health and Environmental Risks opinion on: The environmental risks and indirect health effects of mercury in dental amalgam

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 23rd plenary of 06 May 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, There is also a popularised layman language version of the opinion, Risk Assessment, info:eu-repo/semantics/published

Published
2008

46. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on p-tert-butylphenol Human Health Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 25th plenary of 9 September 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

47. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on 1-(5,6,7,8-tetrahydo-3.5.56.8.8- hexamethyl-2-naphthyl)ethan-1-one (AHTN) Human Health Part (indirect exposure)

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 23rd plenary of 06 May 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

48. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on 4-methyl-m-phenylenediamine Environmental Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 23rd plenary of 06 May 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

49. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on hexabromocyclododecane Environmental Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 23rd plenary of 06 May 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

50. Scientific Committee on Health and Environmental Risks opinion on: Risk Assessment Report on styrene Human Health Part

Author

Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, Viluksela, Matti, Autrup, Herman, Calow, Peter, Dekant, Wolfgang, Greim, Helmut, Wojciech, Hanke, Janssen, Colin, Jansson, Bo, Komulainen, Hannu, Ladefoged, Ole, Linders, Jan, Mangelsdorf, Inge, Nuti, Marco, Steenhout, Anne, Tarazona, Jose, Testai, Emanuela, Vighi, Marco, and Viluksela, Matti

Abstract

Adopted by the SCHER during the 23rd plenary of 06 May 2008, http://ec.europa.eu/health/scientific_committees/environmental_risks/scher_04-09/index_en.htm, http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/scher_opinions_en.htm, Chemicals under Reg.793/93, info:eu-repo/semantics/published

Published
2008

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