450 results on '"Ladds, Graham"'
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2. Binding kinetics drive G protein subtype selectivity at the β1-adrenergic receptor
3. GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
4. Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow
5. Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression
6. ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism.
7. Hit-to-Lead Optimization of Heterocyclic Carbonyloxycarboximidamides as Selective Antagonists at Human Adenosine A3 Receptor.
8. Intracellular pathways of calcitonin gene‐related peptide‐induced relaxation of human coronary arteries: A key role for Gβγ subunit instead of cAMP.
9. Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain.
10. RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis
11. Novel mathematical and computational models of G protein–coupled receptor signalling
12. Proposed model of the Dictyostelium cAMP receptors bound to cAMP
13. Computational Workflow for Refining AlphaFold Models in Drug Design Using Kinetic and Thermodynamic Binding Calculations: A Case Study for the Unresolved Inactive Human Adenosine A3 Receptor
14. Agonist efficacy at the B2AR is driven by agonist-induced differences in receptor affinity for the Gs protein, not ligand binding kinetics.
15. Cancer-Associated Mutations Enhance the Sensitivity of the Trupath Gαq/11 System
16. GLP-1 metabolite GLP-1(9–36) is a systemic inhibitor of mouse and human pancreatic islet glucagon secretion
17. A Computational Workflow for Refining AF2 Models in Drug Design Using Kinetic and Thermodynamic Binding Calculations: A Case Study for the Unresolved Inactive human Adenosine A3 Receptor
18. Combinatorial expression of GPCR isoforms affects signalling and drug responses
19. Parameter identification problems in the modelling of cell motility
20. Structure‐based identification of dual ligands at the A2AR and PDE10A with anti‐proliferative effects in lung cancer cell‐lines
21. Accelerating cryoprotectant diffusion kinetics improves cryopreservation of pancreatic islets
22. CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells
23. Measuring the rapid kinetics of receptor-ligand interactions in live cells using NanoBRET
24. Exploring bias in platelet P2Y1 signalling: Host defence versus haemostasis.
25. Binding kinetics drive G protein subtype selectivity at the β1-adrenergic receptor.
26. Structurally similar G protein complexes with β1-adrenergic receptor active state show differential binding kinetics, mediating selectivity
27. Pharmacological characterisation of novel adenosine A3 receptor antagonists
28. Exploring bias in platelet P2Y1 signalling: host defence versus haemostasis.
29. Integrated biorefinery approach to valorise Saccharina latissima biomass: Combined sustainable processing to produce biologically active fucoxanthin, mannitol, fucoidans and alginates
30. Integrated biorefinery approach to valorise Saccharina latissima biomass : Combined sustainable processing to produce biologically active fucoxanthin, mannitol, fucoidans and alginates
31. Adaptation with the fission yeast Schizosaccharomyces pombe : the characterisation of the secreted serine carboxypeptidase Sxa2
32. Screening microbially produced Δ9-tetrahydrocannabinol using a yeast biosensor workflow
33. Discovery of a High Affinity Adenosine A1/A3 Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold
34. Exploring bias in platelet P2Y1 signalling: host defence versus haemostasis
35. Species-dependent actions of the Goαb selective adenosine A1receptor agonist BnOCPA
36. Author Correction: Combinatorial expression of GPCR isoforms affects signalling and drug responses
37. Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias
38. Discovery and Structure–Activity Relationship Studies of Novel Adenosine A1 Receptor-Selective Agonists
39. Dual A1/A3 Adenosine Receptor Antagonists: Binding Kinetics and Structure−Activity Relationship Studies Using Mutagenesis and Alchemical Binding Free Energy Calculations
40. Cancer-Associated Mutations Enhance The Sensitivity Of The Trupath GαQ/11 System
41. Discovery and Structure-Activity Relationship Studies of Novel Adenosine A1 Receptor-Selective Agonists
42. BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
43. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation
44. Discovery of a High Affinity Adenosine A1/A3 Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold
45. Processing Proteases in S. pombe
46. Parameter identification problems in the modelling of cell motility
47. Species-dependent actions of the Goαb selective adenosine A1 receptor agonist BnOCPA
48. The Role of ICL1 and H8 in Class B1 GPCRs; Implications for Receptor Activation
49. Novel Pyrazolo[3,4-c]pyridine Antagonists with Nanomolar affinity for A1 / A3 Adenosine Receptors: Binding Kinetics and Exploration of their Binding Profile Using Mutagenesis Experiments, MD simulations and TI/MD calculations
50. Discovery and Structure–Activity Relationship Studies of Novel Adenosine A1 Receptor-Selective Agonists.
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