1. A Probiotic Lactobacillus gasseri Alleviates Escherichia coli -Induced Cognitive Impairment and Depression in Mice by Regulating IL-1β Expression and Gut Microbiota.
- Author
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Yun SW, Kim JK, Lee KE, Oh YJ, Choi HJ, Han MJ, and Kim DH
- Subjects
- Animals, Behavior, Animal, Cognitive Dysfunction, Colitis psychology, Depression, Dysbiosis psychology, Dysbiosis therapy, Escherichia coli immunology, Feces microbiology, Gastrointestinal Microbiome immunology, Hippocampus drug effects, Hippocampus metabolism, Lactobacillus gasseri immunology, Lipopolysaccharides, Male, Mice, Mice, Inbred C57BL, NF-kappa B metabolism, Probiotics administration & dosage, Colitis therapy, Escherichia coli physiology, Gastrointestinal Microbiome physiology, Interleukin-1beta metabolism, Lactobacillus gasseri physiology, Microbial Interactions physiology
- Abstract
Excessive expression of interleukin (IL)-1β in the brain causes depression and cognitive dysfunction. Herein, we investigated the effect of Lactobacillus gasseri NK109, which suppressed IL-1β expression in activated macrophages, on Escherichia coli K1-induced cognitive impairment and depression in mice. Germ-free and specific pathogen-free mice with neuropsychiatric disorders were prepared by oral gavage of K1. NK109 alleviated K1-induced cognition-impaired and depressive behaviors, decreased the expression of IL-1β and populations of NF-κB
+ /Iba1+ and IL-1R+ cells, and increased the K1-suppressed population of BDNF+ /NeuN+ cells in the hippocampus. However, its effects were partially attenuated by celiac vagotomy. NK109 treatment mitigated K1-induced colitis and gut dysbiosis. Tyndallized NK109, even if lysed, alleviated cognitive impairment and depression. In conclusion, NK109 alleviated neuropsychiatric disorders and colitis by modulating IL-1β expression, gut microbiota, and vagus nerve-mediated gut-brain signaling. more...- Published
- 2020
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