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992 results on '"Lacroix, Ludovic"'

1. Genomic landscape of liquid biopsy mutations in TP53 and DNA damage genes in cancer patients

Author

Vasseur, Damien, Arbab, Ahmadreza, Giudici, Fabiola, Marzac, Christophe, Michiels, Stefan, Tagliamento, Marco, Bayle, Arnaud, Smolenschi, Cristina, Sakkal, Madona, Aldea, Mihaela, Sassi, Hela, Dall’Olio, Filippo Gustavo, Pata-Merci, Noémie, Cotteret, Sophie, Fiévet, Alice, Auger, Nathalie, Friboulet, Luc, Facchinetti, Francesco, Géraud, Arthur, Ponce, Santiago, Hollebecque, Antoine, Besse, Benjamin, Micol, Jean Baptiste, Italiano, Antoine, Lacroix, Ludovic, and Rouleau, Etienne

Published
2024
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2. Trastuzumab deruxtecan in metastatic breast cancer with variable HER2 expression: the phase 2 DAISY trial

Author

Mosele, Fernanda, Deluche, Elise, Lusque, Amelie, Le Bescond, Loïc, Filleron, Thomas, Pradat, Yoann, Ducoulombier, Agnes, Pistilli, Barbara, Bachelot, Thomas, Viret, Frederic, Levy, Christelle, Signolle, Nicolas, Alfaro, Alexia, Tran, Diep T. N., Garberis, Ingrid Judith, Talbot, Hugues, Christodoulidis, Stergios, Vakalopoulou, Maria, Droin, Nathalie, Stourm, Aurelie, Kobayashi, Maki, Kakegawa, Tomoya, Lacroix, Ludovic, Saulnier, Patrick, Job, Bastien, Deloger, Marc, Jimenez, Marta, Mahier, Celine, Baris, Vianney, Laplante, Pierre, Kannouche, Patricia, Marty, Virginie, Lacroix-Triki, Magali, Diéras, Veronique, and André, Fabrice

Published
2023
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4. Development of Novel Models of Aggressive Variants of Castration-resistant Prostate Cancer

Author

Bigot, Ludovic, Sabio, Jonathan, Poiraudeau, Loic, Annereau, Maxime, Menssouri, Naoual, Helissey, Carole, Déas, Olivier, Aglave, Marine, Ibrahim, Tony, Pobel, Cédric, Nobre, Catline, Nicotra, Claudio, Ngo-Camus, Maud, Lacroix, Ludovic, Rouleau, Etienne, Tselikas, Lambros, Judde, Jean-Gabriel, Chauchereau, Anne, Bernard-Tessier, Alice, Patrikidou, Anna, Naoun, Natacha, Flippot, Ronan, Colomba, Emeline, Fuerea, Alina, Albiges, Laurence, Lavaud, Pernelle, Massard, Christophe, Friboulet, Luc, Fizazi, Karim, Besse, Benjamin, Scoazec, Jean-Yves, and Loriot, Yohann

Published
2024
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6. Circulating tumor DNA landscape and prognostic impact of acquired resistance to targeted therapies in cancer patients: a national center for precision medicine (PRISM) study

Author

Bayle, Arnaud, Belcaid, Laila, Palmieri, Lola-Jade, Teysonneau, Diego, Cousin, Sophie, Spalato-Ceruso, Mariella, Aldea, Mihaela, Vasseur, Damien, Alame, Melissa, Blouin, Laura, Soubeyran, Isabelle, Nicotra, Claudio, Ngocamus, Maud, Hollebecque, Antoine, Loriot, Yohann, Besse, Benjamin, Lacroix, Ludovic, Rouleau, Etienne, Barlesi, Fabrice, Andre, Fabrice, and Italiano, Antoine

Published
2023
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7. A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors

Author

Marques Da Costa, Maria Eugénia, Zaidi, Sakina, Scoazec, Jean-Yves, Droit, Robin, Lim, Wan Ching, Marchais, Antonin, Salmon, Jerome, Cherkaoui, Sarah, Morscher, Raphael J., Laurent, Anouchka, Malinge, Sébastien, Mercher, Thomas, Tabone-Eglinger, Séverine, Goddard, Isabelle, Pflumio, Francoise, Calvo, Julien, Redini, Francoise, Entz-Werlé, Natacha, Soriano, Aroa, Villanueva, Alberto, Cairo, Stefano, Chastagner, Pascal, Moro, Massimo, Owens, Cormac, Casanova, Michela, Hladun-Alvaro, Raquel, Berlanga, Pablo, Daudigeos-Dubus, Estelle, Dessen, Philippe, Zitvogel, Laurence, Lacroix, Ludovic, Pierron, Gaelle, Delattre, Olivier, Schleiermacher, Gudrun, Surdez, Didier, and Geoerger, Birgit

Published
2023
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8. Hepatic arterial oxaliplatin plus intravenous 5-fluorouracil and cetuximab for first-line treatment of colorectal liver metastases: A multicenter phase II trial

Author

Malka, David, Verret, Benjamin, Faron, Matthieu, Guimbaud, Rosine, Caramella, Caroline, Edeline, Julien, Galais, Marie-Pierre, Bengrine-Lefevre, Leïla, Smith, Denis, Dupont-Bierre, Eric, De Baere, Thierry, Goéré, Diane, Dartigues, Peggy, Lacroix, Ludovic, Boige, Valérie, Gelli, Maximiliano, Pignon, Jean-Pierre, and Ducreux, Michel

Published
2023
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9. Clinical utility of plasma ctDNA sequencing in metastatic urothelial cancer

Author

Helal, Clara, Pobel, Cédric, Bayle, Arnaud, Vasseur, Damien, Nicotra, Claudio, Blanc-Durand, Félix, Naoun, Natacha, Bernard-Tessier, Alice, Patrikidou, Anna, Colomba, Emeline, Flippot, Ronan, Fuerea, Alina, Auger, Nathalie, Ngo Camus, Maud, Besse, Benjamin, Lacroix, Ludovic, Rouleau, Etienne, Ponce, Santiago, Italiano, Antoine, and Loriot, Yohann

Published
2023
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10. Genomics to select treatment for patients with metastatic breast cancer

Author

Andre, Fabrice, Filleron, Thomas, Kamal, Maud, Mosele, Fernanda, Arnedos, Monica, Dalenc, Florence, Sablin, Marie-Paule, Campone, Mario, Bonnefoi, Hervé, Lefeuvre-Plesse, Claudia, Jacot, William, Coussy, Florence, Ferrero, Jean-Marc, Emile, George, Mouret-Reynier, Marie-Ange, Thery, Jean-Christophe, Isambert, Nicolas, Mege, Alice, Barthelemy, Philippe, You, Benoit, Hajjaji, Nawale, Lacroix, Ludovic, Rouleau, Etienne, Tran-Dien, Alicia, Boyault, Sandrine, Attignon, Valery, Gestraud, Pierre, Servant, Nicolas, Le Tourneau, Christophe, Cherif, Linda Larbi, Soubeyran, Isabelle, Montemurro, Filippo, Morel, Alain, Lusque, Amelie, Jimenez, Marta, Jacquet, Alexandra, Gonçalves, Anthony, Bachelot, Thomas, and Bieche, Ivan

Published
2022
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11. An evaluation of cell-free tumor DNA from 20 mL of peritoneal fluid for homologous recombination deficiency (HRD) testing in newly diagnosed ovarian cancer (OC).

Author

Roussel-Simonin, Cyril, primary, Tang, Rosaline, additional, Blanc-Durand, Felix, additional, Vasseur, Damien, additional, Le Formal, Audrey, additional, Chardin, Laure, additional, Yaniz, Elisa, additional, Gouy, Sebastien, additional, Scherier, Stephanie, additional, Maulard, Amandine, additional, Pautier, Patricia, additional, Michels, Judith, additional, Lacroix, Ludovic, additional, Rouleau, Etienne, additional, and Leary, Alexandra, additional

Published
2024
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13. Epigenetic gene alterations in metastatic solid tumours: results from the prospective precision medicine MOSCATO and MATCH-R trials

Author

Martin-Romano, Patricia, Colmet-Daage, Leo, Morel, Daphne, Baldini, Capucine, Verlingue, Loic, Bahleda, Rastilav, Gazzah, Anas, Champiat, Stephan, Varga, Andree, Michot, Jean Marie, Ngo-Camus, Maud, Nicotra, Claudio, Marabelle, Aurelien, Soria, Jean Charles, Rouleau, Etienne, Lacroix, Ludovic, Hollebecque, Antoine, Massard, Christophe, and Postel-Vinay, Sophie

Published
2022
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14. Clinical Utility and Outcomes Impact of Crystal Digital PCR of Sensitizing and Resistance EGFR Mutations in Patients With Advanced Non-Small Cell Lung Cancer

Author

Riudavets, Mariona, Lamberts, Virginie, Vasseur, Damien, Auclin, Edouard, Aldea, Mihaela, Jovelet, Cécile, Naltet, Charles, Lavaud, Pernelle, Gazzah, Anas, Aboubakar, Frank, Dorta, Miriam, Remon, Jordi, Rouleau, Etienne, Ngocamus, Maud, Nicotra, Claudio, Lacroix, Ludovic, Besse, Benjamin, Mezquita, Laura, and Planchard, David

Published
2022
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16. Safety, recommended dose, efficacy and immune correlates for nintedanib in combination with pembrolizumab in patients with advanced cancers

Author

Baldini, Capucine, Danlos, Francois-Xavier, Varga, Andreea, Texier, Matthieu, Halse, Heloise, Mouraud, Severine, Cassard, Lydie, Champiat, Stéphane, Signolle, Nicolas, Vuagnat, Perrine, Martin-Romano, Patricia, Michot, Jean-Marie, Bahleda, Rastislav, Gazzah, Anas, Boselli, Lisa, Bredel, Delphine, Grivel, Jonathan, Mohamed-Djalim, Chifaou, Escriou, Guillaume, Grynszpan, Laetitia, Bigorgne, Amelie, Rafie, Saloomeh, Abbassi, Alae, Ribrag, Vincent, Postel-Vinay, Sophie, Hollebecque, Antoine, Susini, Sandrine, Farhane, Siham, Lacroix, Ludovic, Parpaleix, Aurelien, Laghouati, Salim, Zitvogel, Laurence, Adam, Julien, Chaput, Nathalie, Soria, Jean-Charles, Massard, Christophe, and Marabelle, Aurelien

Published
2022
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18. Clinical utility of comprehensive liquid molecular profiling in patients with advanced endometrial cancer.

Author

Blanc‐Durand, Félix, Camilleri, Geraldine M., Bayle, Arnaud, Aldea, Mihaela, Vasseur, Damien, Ouali, Kaissa, Michels, Judith, Pautier, Patricia, Nicotra, Claudio, Ngo‐Camus, Maud, Lacroix, Ludovic, Rouleau, Etienne, Ponce‐Aix, Santiago, Italiano, Antoine, and Leary, Alexandra

Subjects
CANCER patients, ENDOMETRIAL cancer, CELL-free DNA, MEDICAL societies, DRUG target
Abstract

Background: Molecular characterization has significantly improved the management of advanced endometrial cancer (EC). It distinguishes four molecular subclasses associated with prognosis and personalized therapeutic strategies. This study assesses the clinical utility of cell‐free DNA (cfDNA) profiling in EC to identify targetable alterations. Methods: Women with metastatic or recurrent EC were prospectively recruited within the framework of the STING trial (NCT04932525), during which cfDNA was analyzed. Genomic alterations were identified with the FoundationOne CDx assay. Each molecular report underwent review by a molecular tumor board. Alterations were categorized via the European Society of Medical Oncology Scale for Clinical Actionability of Molecular Targets (ESCAT). Results: A total of 61 patients were enrolled. The median age was 66.9 years, with 43% presenting frontline metastatic disease. All histologic subgroups were represented. Notably, 89% of patients yielded informative cfDNA analysis. Six tumors were classified with deficient mismatch repair/microsatellite instability (11%) and 37 as TP53 gene mutant (67%), and 12 had nonspecific molecular profiles (22%). Molecular classification based on liquid biopsy showed 87.5% accuracy in correlating with tissue results. Moreover, 65% of cases exhibited ≥1 actionable alteration, including 25% ESCAT I alterations and 13% ESCAT II alterations. Consequently, 16% of patients received a molecularly matched therapy, and presented with a 56% response rate and median progression‐free survival of 7.7 months. Conclusions: cfDNA sequencing in EC is a feasible approach that produces informative results in 89% of cases and accurately categorizes patients into the main molecular subclasses. It also reveals multiple actionable alterations, which offers the potential for personalized therapeutic strategies. Cell‐free DNA sequencing is a highly feasible assay that allows an accurate molecular characterization of patients with advanced endometrial cancer while detecting multiple actionable alterations. It serves as a valuable tool for tailoring the management of patients with metastatic endometrial cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Impact of Clonal Hematopoiesis–Associated Mutations in Phase I Patients Treated for Solid Tumors: An Analysis of the STING Trial.

Author

Rodriguez, Julieta, Baldini, Capucine, Bayle, Arnaud, Pages, Arnaud, Danlos, François Xavier, Vasseur, Damien, Rouleau, Etienne, Lacroix, Ludovic, Alonso de Castro, Beatriz, Goldschmidt, Vincent, Seknazi, Lauren, Hollebecque, Antoine, Michot, Jean-Marie, Champiat, Stephane, Marabelle, Aurelien, Ouali, Kaissa, Marzac, Christophe, Ponce, Santiago, Micol, Jean-Baptiste, and Chaput, Nathalie

Subjects
OVERALL survival, PROGRESSION-free survival, DRUG administration, GENE frequency, MEDICAL records
Abstract

PURPOSE: With liquid biopsy's widespread adoption in oncology, an increased number of clonal hematopoiesis–associated mutations (CHm) have been identified in patients with solid tumors. However, its impact on patient outcomes remains unclear. This study aimed to analyze and describe CHm in a cohort of phase I patients. METHODS: Retrospective data collection from medical records and molecular profiles (Foundation One Liquid CDx Assay) was performed before first study drug administration at the Drug Development Department of Gustave Roussy (France) within the STING trial (ClinicalTrials.gov identifier: NCT04932525). CHm prevalence was assessed using any and ≥1% variant allele frequency (VAF) in epigenetic modifier genes (DNMT3A , TET2 , and ASXL1). RESULTS: From January 2021 to December 2022, 255 patients were enrolled in a phase I clinical trial. A total of 55% were male, with a median age of 62 years (24-86). Principal tumor locations were GI (27%) and genitourinary (21%). Overall, 104 patients (41%) had at least one CHm in liquid biopsy, with 55 patients (22%) having a VAF of ≥ 1%. The most frequent mutation was DNMT3A 73% at any VAF (n = 76) and 22% at 1% VAF (n = 23). Median progression-free survival (PFS) and overall survival were 3.8 months (m) for the CHm group versus 3.2 m for nonclonal hematopoiesis (CH; P =.08) and 18.26 m CHm versus 15.8 m non-CH (P =.9), respectively. PFS increased in the CHm population treated with targeted therapy (hazard ratio, 0.6 [95% CI, 0.42 to 0.84]; P =.004). CONCLUSION: CHm was commonly found in patients with solid tumors treated in phase I trials, with a prevalence of 41% in our cohort. The most frequently mutated gene was DNMT3A. The presence of CHm had no impact on the population of patients treated in the phase I trials. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Circulating Tumor DNA Analysis for Patients with Oncogene-Addicted NSCLC With Isolated Central Nervous System Progression

Author

Aldea, Mihaela, Hendriks, Lizza, Mezquita, Laura, Jovelet, Cécile, Planchard, David, Auclin, Edouard, Remon, Jordi, Howarth, Karen, Benitez, Jose Carlos, Gazzah, Anas, Lavaud, Pernelle, Naltet, Charles, Lacroix, Ludovic, de Kievit, Frank, Morris, Clive, Green, Emma, Ngo-Camus, Maud, Rouleau, Etienne, Massard, Christophe, Caramella, Caroline, Friboulet, Luc, and Besse, Benjamin

Published
2020
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22. Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8 + T cells in patients with advanced NSCLC

Author

Naigeon, Marie, primary, Roulleaux Dugage, Matthieu, additional, Danlos, François-Xavier, additional, Boselli, Lisa, additional, Jouniaux, Jean-Mehdi, additional, de Oliveira, Caroline, additional, Ferrara, Roberto, additional, Duchemann, Boris, additional, Berthot, Caroline, additional, Girard, Lou, additional, Flippot, Ronan, additional, Albiges, Laurence, additional, Farhane, Siham, additional, Saulnier, Patrick, additional, Lacroix, Ludovic, additional, Griscelli, Frank, additional, Roman, Gabriel, additional, Hulett, Tyler, additional, Marabelle, Aurélien, additional, Cassard, Lydie, additional, Besse, Benjamin, additional, and Chaput, Nathalie, additional

Published
2023
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23. Supplementary Data S1 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors

Author

Menssouri, Naoual, primary, Poiraudeau, Loïc, primary, Helissey, Carole, primary, Bigot, Ludovic, primary, Sabio, Jonathan, primary, Ibrahim, Tony, primary, Pobel, Cédric, primary, Nicotra, Claudio, primary, Ngo-Camus, Maud, primary, Lacroix, Ludovic, primary, Rouleau, Etienne, primary, Tselikas, Lambros, primary, Chauchereau, Anne, primary, Blanc-Durand, Félix, primary, Bernard-Tessier, Alice, primary, Patrikidou, Anna, primary, Naoun, Natacha, primary, Flippot, Ronan, primary, Colomba, Emeline, primary, Fuerea, Alina, primary, Albiges, Laurence, primary, Lavaud, Pernelle, primary, van de Wiel, Paul, primary, den Biezen, Eveline, primary, Wesseling-Rozendaal, Yvonne, primary, Ponce, Santiago, primary, Michiels, Stefan, primary, Massard, Christophe, primary, Gautheret, Daniel, primary, Barlesi, Fabrice, primary, André, Fabrice, primary, Besse, Benjamin, primary, Scoazec, Jean-Yves, primary, Friboulet, Luc, primary, Fizazi, Karim, primary, and Loriot, Yohann, primary

Published
2023
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24. Supplementary Figure S2 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors

Author

Menssouri, Naoual, primary, Poiraudeau, Loïc, primary, Helissey, Carole, primary, Bigot, Ludovic, primary, Sabio, Jonathan, primary, Ibrahim, Tony, primary, Pobel, Cédric, primary, Nicotra, Claudio, primary, Ngo-Camus, Maud, primary, Lacroix, Ludovic, primary, Rouleau, Etienne, primary, Tselikas, Lambros, primary, Chauchereau, Anne, primary, Blanc-Durand, Félix, primary, Bernard-Tessier, Alice, primary, Patrikidou, Anna, primary, Naoun, Natacha, primary, Flippot, Ronan, primary, Colomba, Emeline, primary, Fuerea, Alina, primary, Albiges, Laurence, primary, Lavaud, Pernelle, primary, van de Wiel, Paul, primary, den Biezen, Eveline, primary, Wesseling-Rozendaal, Yvonne, primary, Ponce, Santiago, primary, Michiels, Stefan, primary, Massard, Christophe, primary, Gautheret, Daniel, primary, Barlesi, Fabrice, primary, André, Fabrice, primary, Besse, Benjamin, primary, Scoazec, Jean-Yves, primary, Friboulet, Luc, primary, Fizazi, Karim, primary, and Loriot, Yohann, primary

Published
2023
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25. Supplementary Methods S1 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors

Author

Menssouri, Naoual, primary, Poiraudeau, Loïc, primary, Helissey, Carole, primary, Bigot, Ludovic, primary, Sabio, Jonathan, primary, Ibrahim, Tony, primary, Pobel, Cédric, primary, Nicotra, Claudio, primary, Ngo-Camus, Maud, primary, Lacroix, Ludovic, primary, Rouleau, Etienne, primary, Tselikas, Lambros, primary, Chauchereau, Anne, primary, Blanc-Durand, Félix, primary, Bernard-Tessier, Alice, primary, Patrikidou, Anna, primary, Naoun, Natacha, primary, Flippot, Ronan, primary, Colomba, Emeline, primary, Fuerea, Alina, primary, Albiges, Laurence, primary, Lavaud, Pernelle, primary, van de Wiel, Paul, primary, den Biezen, Eveline, primary, Wesseling-Rozendaal, Yvonne, primary, Ponce, Santiago, primary, Michiels, Stefan, primary, Massard, Christophe, primary, Gautheret, Daniel, primary, Barlesi, Fabrice, primary, André, Fabrice, primary, Besse, Benjamin, primary, Scoazec, Jean-Yves, primary, Friboulet, Luc, primary, Fizazi, Karim, primary, and Loriot, Yohann, primary

Published
2023
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26. Supplementary Table S1 from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors

Author

Menssouri, Naoual, primary, Poiraudeau, Loïc, primary, Helissey, Carole, primary, Bigot, Ludovic, primary, Sabio, Jonathan, primary, Ibrahim, Tony, primary, Pobel, Cédric, primary, Nicotra, Claudio, primary, Ngo-Camus, Maud, primary, Lacroix, Ludovic, primary, Rouleau, Etienne, primary, Tselikas, Lambros, primary, Chauchereau, Anne, primary, Blanc-Durand, Félix, primary, Bernard-Tessier, Alice, primary, Patrikidou, Anna, primary, Naoun, Natacha, primary, Flippot, Ronan, primary, Colomba, Emeline, primary, Fuerea, Alina, primary, Albiges, Laurence, primary, Lavaud, Pernelle, primary, van de Wiel, Paul, primary, den Biezen, Eveline, primary, Wesseling-Rozendaal, Yvonne, primary, Ponce, Santiago, primary, Michiels, Stefan, primary, Massard, Christophe, primary, Gautheret, Daniel, primary, Barlesi, Fabrice, primary, André, Fabrice, primary, Besse, Benjamin, primary, Scoazec, Jean-Yves, primary, Friboulet, Luc, primary, Fizazi, Karim, primary, and Loriot, Yohann, primary

Published
2023
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27. Alkylating Agent-Induced High Tumor Mutational Burden in Medullary Thyroid Cancer and Response to Immune Checkpoint Inhibitors: Two Case Reports

Author

Moog, Sophie, primary, Lamartina, Livia, additional, Bani, Mohamed-Amine, additional, Al Ghuzlan, Abir, additional, Friboulet, Luc, additional, Italiano, Antoine, additional, Lacroix, Ludovic, additional, Postel Vinay, Sophie, additional, Tselikas, Lambros, additional, Deschamps, Frédéric, additional, Bonnet, Baptiste, additional, Pani, Fabiana, additional, Baudin, Eric, additional, and Hadoux, Julien, additional

Published
2023
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28. Association of the Genomic Profile of Medullary Thyroid Carcinoma with Tumor Characteristics and Clinical Outcomes in an International Multicenter Study

Author

Xu, Bin, primary, Viswanathan, Kartik, additional, Ahadi, Mahsa S., additional, Ahmadi, Sara, additional, Alzumaili, Bayan, additional, Bani, Mohamed-Amine, additional, Baudin, Eric, additional, Behrman, David Blake, additional, Capelletti, Marzia, additional, Chau, Nicole G, additional, Chiarucci, Federico, additional, Chou, Angela, additional, Clifton-Bligh, Roderick, additional, Coluccelli, Sara, additional, de Biase, Dario, additional, De Leo, Antonio, additional, Dogan, Snjezana, additional, Fagin, James A, additional, Fuchs, Talia, additional, Glover, Anthony Robert, additional, Hadoux, Julien, additional, Lacroix, Ludovic, additional, Lamartina, Livia, additional, Lubin, Daniel J., additional, Luxford, Catherine, additional, Magliocca, Kelly, additional, Maloberti, Thais, additional, Mohanty, Abhinita S., additional, Najdawi, Fedaa, additional, Nigam, Aradhya, additional, Papachristos, Alexander James, additional, Repaci, Andrea, additional, Robinson, Bruce, additional, Scoazec, Jean-Yves, additional, Shi, Qiuying, additional, Sidhu, Stan, additional, Solaroli, Erica, additional, Sywak, Mark, additional, Tuttle, R Michael, additional, Untch, Brian R, additional, Barletta, Justine A, additional, Al Ghuzlan, Abir, additional, Gill, Anthony J, additional, Ghossein, Ronald, additional, Tallini, Giovanni, additional, and Ganly, Ian, additional

Published
2023
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29. Development of Novel Models of Aggressive Variants of Castration-resistant Prostate Cancer

Author

Bigot, Ludovic, primary, Sabio, Jonathan, additional, Poiraudeau, Loic, additional, Annereau, Maxime, additional, Menssouri, Naoual, additional, Helissey, Carole, additional, Déas, Olivier, additional, Aglave, Marine, additional, Ibrahim, Tony, additional, Pobel, Cédric, additional, Nobre, Catline, additional, Nicotra, Claudio, additional, Ngo-Camus, Maud, additional, Lacroix, Ludovic, additional, Rouleau, Etienne, additional, Tselikas, Lambros, additional, Judde, Jean-Gabriel, additional, Chauchereau, Anne, additional, Bernard-Tessier, Alice, additional, Patrikidou, Anna, additional, Naoun, Natacha, additional, Flippot, Ronan, additional, Colomba, Emeline, additional, Fuerea, Alina, additional, Albiges, Laurence, additional, Lavaud, Pernelle, additional, Massard, Christophe, additional, Friboulet, Luc, additional, Fizazi, Karim, additional, Besse, Benjamin, additional, Scoazec, Jean-Yves, additional, and Loriot, Yohann, additional

Published
2023
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30. Determinants of the outcomes of patients with cancer infected with SARS-CoV-2: results from the Gustave Roussy cohort

Author

Albiges, Laurence, Foulon, Stéphanie, Bayle, Arnaud, Gachot, Bertrand, Pommeret, Fanny, Willekens, Christophe, Stoclin, Annabelle, Merad, Mansouria, Griscelli, Frank, Lacroix, Ludovic, Netzer, Florence, Hueso, Thomas, Balleyguier, Corinne, Ammari, Samy, Colomba, Emeline, Baciarello, Giulia, Perret, Audrey, Hollebecque, Antoine, Hadoux, Julien, Michot, Jean-Marie, Chaput, Nathalie, Saada, Veronique, Hauchecorne, Mathilde, Micol, Jean-Baptiste, Sun, Roger, Valteau-Couanet, Dominique, André, Fabrice, Scotte, Florian, Besse, Benjamin, Soria, Jean-Charles, and Barlesi, Fabrice

Published
2020
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31. Implementing the European Society for Medical Oncology Scale for Clinical Actionability of Molecular Targets in a Comprehensive Profiling Program: Impact on Precision Medicine Oncology

Author

Martin-Romano, Patricia, Mezquita, Laura, Hollebecque, Antoine, Lacroix, Ludovic, Rouleau, Etienne, Gazzah, Anas, Bahleda, Rastilav, Planchard, David, Varga, Andrea, Baldini, Capucine, Postel-Vinay, Sophie, Friboulet, Luc, Loriot, Yohann, Verlingue, Loic, Geraud, Arthur, Camus, Maud Ngo, Nicotra, Claudio, Soria, Jean Charles, André, Fabrice, Besse, Benjamin, Massard, Christophe, and Italiano, Antoine

Published
2022
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32. Association of metastatic pattern and molecular status in stage IV non-small cell lung cancer adenocarcinoma

Author

Dormieux, Alison, Mezquita, Laura, Cournede, Paul Henry, Remon, Jordi, Tazdait, Melodie, Lacroix, Ludovic, Rouleau, Etienne, Adam, Julien, Bluthgen, Maria-Virginia, Facchinetti, Francesco, Tselikas, Lambros, Aboubakar, Frank, Naltet, Charles, Lavaud, Pernelle, Gazzah, Anas, Le Pechoux, Cécile, Lassau, Nathalie, Balleyguier, Corinne, Planchard, David, Besse, Benjamin, and Caramella, Caroline

Published
2020
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34. A simplified interventional mapping system (SIMS) for the selection of combinations of targeted treatments in non-small cell lung cancer

Author

Lazar, Vladimir, Rubin, Eitan, Depil, Stephane, Pawitan, Yudi, Martini, Jean-François, Gomez-Navarro, Jesus, Yver, Antoine, Kan, Zhengyin, Dry, Jonathan R, Kehren, Jeanne, Validire, Pierre, Rodon, Jordi, Vielh, Philippe, Ducreux, Michel, Galbraith, Susan, Lehnert, Manfred, Onn, Amir, Berger, Raanan, Pierotti, Marco A, Porgador, Angel, Pramesh, CS, Ye, Ding-wei, Carvalho, Andre L, Batist, Gerald, Le Chevalier, Thierry, Morice, Philippe, Besse, Benjamin, Vassal, Gilles, Mortlock, Andrew, Hansson, Johan, Berindan-Neagoe, Ioana, Dann, Robert, Haspel, Joel, Irimie, Alexandru, Laderman, Steve, Nechushtan, Hovav, Omari, Amal S Al, Haywood, Trent, Bresson, Catherine, Soo, Khee Chee, Osman, Iman, Mata, Hilario, Lee, Jack J, Jhaveri, Komal, Meurice, Guillaume, Palmer, Gary, Lacroix, Ludovic, Koscielny, Serge, Eterovic, Karina Agda, Blay, Jean-Yves, Buller, Richard, Eggermont, Alexander, Schilsky, Richard L, Mendelsohn, John, Soria, Jean-Charles, Rothenberg, Mace, Scoazec, Jean-Yves, Hong, Waun Ki, and Kurzrock, Razelle

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Lung, Biotechnology, Cancer, Lung Cancer, Adult, Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Non-Small-Cell Lung, Female, Humans, Lung Neoplasms, Male, Middle Aged, Molecular Targeted Therapy, Precision Medicine, Transcriptome, Tri-therapy, NSCLC, targeted therapies, algorithm, pathway, tri-therapy, Oncology and carcinogenesis
Abstract

Non-small cell lung cancer (NSCLC) is a leading cause of death worldwide. Targeted monotherapies produce high regression rates, albeit for limited patient subgroups, who inevitably succumb. We present a novel strategy for identifying customized combinations of triplets of targeted agents, utilizing a simplified interventional mapping system (SIMS) that merges knowledge about existent drugs and their impact on the hallmarks of cancer. Based on interrogation of matched lung tumor and normal tissue using targeted genomic sequencing, copy number variation, transcriptomics, and miRNA expression, the activation status of 24 interventional nodes was elucidated. An algorithm was developed to create a scoring system that enables ranking of the activated interventional nodes for each patient. Based on the trends of co-activation at interventional points, combinations of drug triplets were defined in order to overcome resistance. This methodology will inform a prospective trial to be conducted by the WIN consortium, aiming to significantly impact survival in metastatic NSCLC and other malignancies.

Published
2015

36. Patterns of Treatment Failure After Selective Rearranged During Transfection (RET) Inhibitors in Patients With Metastatic Medullary Thyroid Carcinoma

Author

Hadoux, Julien, primary, Al Ghuzlan, Abir, additional, Lamartina, Livia, additional, Bani, Mohamed-Amine, additional, Moog, Sophie, additional, Attard, Marie, additional, Scoazec, Jean Yves, additional, Hartl, Dana, additional, Aldea, Mihaela, additional, Friboulet, Luc, additional, Jules-Clement, Gerome, additional, Italiano, Antoine, additional, Besse, Benjamin, additional, Lacroix, Ludovic, additional, and Baudin, Eric, additional

Published
2023
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37. #64 Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid of patient with epithelial ovarian cancer

Author

Roussel-Simonin, Cyril, primary, Blanc-Durand, Felix, additional, Tang, Roseline, additional, Vasseur, Damien, additional, Formal, Audrey Le, additional, Chardin, Laure, additional, Gouy, Sebastien, additional, Maulard, Amandine, additional, Scherier, Stephanie, additional, Sanson, Claire, additional, Lacroix, Ludovic, additional, Cotteret, Sophie, additional, Mauny, Lea, additional, Zaccarini, Francois, additional, Rouleau, Etienne, additional, and Leary, Alexandra, additional

Published
2023
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38. MERAIODE: A Phase II Redifferentiation Trial with Trametinib and 131I in Metastatic Radioactive Iodine Refractory RAS Mutated Differentiated Thyroid Cancer

Author

Leboulleux, Sophie, primary, Benisvy, Daniele, additional, Taieb, David, additional, Attard, Marie, additional, Bournaud, Claire, additional, Terroir-Cassou-Mounat, Marie, additional, Lacroix, Ludovic, additional, Anizan, Nadege, additional, Schiazza, Aurelie, additional, Garcia, Marie Eve, additional, Ghuzlan, Abir Al, additional, Lamartina, Livia, additional, Schlumberger, Martin, additional, Godbert, Yann, additional, and Borget, Isabelle, additional

Published
2023
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39. Data from Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors

Author

Menssouri, Naoual, primary, Poiraudeau, Loïc, primary, Helissey, Carole, primary, Bigot, Ludovic, primary, Sabio, Jonathan, primary, Ibrahim, Tony, primary, Pobel, Cédric, primary, Nicotra, Claudio, primary, Ngo-Camus, Maud, primary, Lacroix, Ludovic, primary, Rouleau, Etienne, primary, Tselikas, Lambros, primary, Chauchereau, Anne, primary, Blanc-Durand, Félix, primary, Bernard-Tessier, Alice, primary, Patrikidou, Anna, primary, Naoun, Natacha, primary, Flippot, Ronan, primary, Colomba, Emeline, primary, Fuerea, Alina, primary, Albiges, Laurence, primary, Lavaud, Pernelle, primary, van de Wiel, Paul, primary, den Biezen, Eveline, primary, Wesseling-Rozendaal, Yvonne, primary, Ponce, Santiago, primary, Michiels, Stefan, primary, Massard, Christophe, primary, Gautheret, Daniel, primary, Barlesi, Fabrice, primary, André, Fabrice, primary, Besse, Benjamin, primary, Scoazec, Jean-Yves, primary, Friboulet, Luc, primary, Fizazi, Karim, primary, and Loriot, Yohann, primary

Published
2023
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40. Genomic Profiling of Metastatic Castration-Resistant Prostate Cancer Samples Resistant to Androgen Receptor Pathway Inhibitors

Author

Menssouri, Naoual, primary, Poiraudeau, Loïc, additional, Helissey, Carole, additional, Bigot, Ludovic, additional, Sabio, Jonathan, additional, Ibrahim, Tony, additional, Pobel, Cédric, additional, Nicotra, Claudio, additional, Ngo-Camus, Maud, additional, Lacroix, Ludovic, additional, Rouleau, Etienne, additional, Tselikas, Lambros, additional, Chauchereau, Anne, additional, Blanc-Durand, Félix, additional, Bernard-Tessier, Alice, additional, Patrikidou, Anna, additional, Naoun, Natacha, additional, Flippot, Ronan, additional, Colomba, Emeline, additional, Fuerea, Alina, additional, Albiges, Laurence, additional, Lavaud, Pernelle, additional, van de Wiel, Paul, additional, den Biezen, Eveline, additional, Wesseling-Rozendaal, Yvonne, additional, Ponce, Santiago, additional, Michiels, Stefan, additional, Massard, Christophe, additional, Gautheret, Daniel, additional, Barlesi, Fabrice, additional, André, Fabrice, additional, Besse, Benjamin, additional, Scoazec, Jean-Yves, additional, Friboulet, Luc, additional, Fizazi, Karim, additional, and Loriot, Yohann, additional

Published
2023
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41. Combined Tumor-Based BRCA1/2 and TP53 Mutation Testing in Ovarian Cancer

Author

Borcoman, Edith, primary, Santana dos Santos, Elizabeth, additional, Genestie, Catherine, additional, Pautier, Patricia, additional, Lacroix, Ludovic, additional, Caputo, Sandrine M., additional, Cabaret, Odile, additional, Guillaud-Bataille, Marine, additional, Michels, Judith, additional, Auguste, Aurelie, additional, Leary, Alexandra, additional, and Rouleau, Etienne, additional

Published
2023
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43. Human epidermal receptor family inhibitors in patients with ERBB3 mutated cancers: Entering the back door

Author

Verlingue, Loic, Hollebecque, Antoine, Lacroix, Ludovic, Postel-Vinay, Sophie, Varga, Andrea, El Dakdouki, Yolla, Baldini, Capucine, Balheda, Rastilav, Gazzah, Anas, Michot, Jean-Marie, Marabelle, Aurélien, Mir, Olivier, Arnedos, Monica, Rouleau, Etienne, Solary, Eric, De Baere, Thierry, Angevin, Eric, Armand, Jean-Pierre, Michiels, Stefan, André, Fabrice, Deutsch, Eric, Scoazec, Jean-Yves, Soria, Jean-Charles, and Massard, Christophe

Published
2018
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45. Precision medicine for patients with advanced biliary tract cancers: An effective strategy within the prospective MOSCATO-01 trial

Author

Verlingue, Loic, Malka, David, Allorant, Adrien, Massard, Christophe, Ferté, Charles, Lacroix, Ludovic, Rouleau, Etienne, Auger, Nathalie, Ngo, Maud, Nicotra, Claudio, De Baere, Thierry, Tselikas, Lambros, Ba, Bakar, Michiels, Stefan, Scoazec, Jean-Yves, Boige, Valérie, Ducreux, Michel, Soria, Jean-Charles, and Hollebecque, Antoine

Published
2017
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46. Supplementary Table S5 from A Phase II Redifferentiation Trial with Dabrafenib-Trametinib and 131I in Metastatic Radioactive Iodine Refractory BRAF p.V600E-Mutated Differentiated Thyroid Cancer

Author

Leboulleux, Sophie, primary, Do Cao, Christine, primary, Zerdoud, Slimane, primary, Attard, Marie, primary, Bournaud, Claire, primary, Lacroix, Ludovic, primary, Benisvy, Danielle, primary, Taïeb, David, primary, Bardet, Stéphane, primary, Terroir-Cassou-Mounat, Marie, primary, Anizan, Nadège, primary, Bouvier-Morel, Emilie, primary, Lamartina, Livia, primary, Lion, Georges, primary, Betrian, Sarah, primary, Sajous, Christophe, primary, Schiazza, Aurélie, primary, Garcia, Marie-Eve, primary, Ciappuccini, Renaud, primary, Schlumberger, Martin, primary, Al Ghuzlan, Abir, primary, Godbert, Yann, primary, and Borget, Isabelle, primary

Published
2023
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47. Supplementary Figure S2 from A Phase II Redifferentiation Trial with Dabrafenib-Trametinib and 131I in Metastatic Radioactive Iodine Refractory BRAF p.V600E-Mutated Differentiated Thyroid Cancer

Author

Leboulleux, Sophie, primary, Do Cao, Christine, primary, Zerdoud, Slimane, primary, Attard, Marie, primary, Bournaud, Claire, primary, Lacroix, Ludovic, primary, Benisvy, Danielle, primary, Taïeb, David, primary, Bardet, Stéphane, primary, Terroir-Cassou-Mounat, Marie, primary, Anizan, Nadège, primary, Bouvier-Morel, Emilie, primary, Lamartina, Livia, primary, Lion, Georges, primary, Betrian, Sarah, primary, Sajous, Christophe, primary, Schiazza, Aurélie, primary, Garcia, Marie-Eve, primary, Ciappuccini, Renaud, primary, Schlumberger, Martin, primary, Al Ghuzlan, Abir, primary, Godbert, Yann, primary, and Borget, Isabelle, primary

Published
2023
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48. Data from A Phase II Redifferentiation Trial with Dabrafenib-Trametinib and 131I in Metastatic Radioactive Iodine Refractory BRAF p.V600E-Mutated Differentiated Thyroid Cancer

Author

Leboulleux, Sophie, primary, Do Cao, Christine, primary, Zerdoud, Slimane, primary, Attard, Marie, primary, Bournaud, Claire, primary, Lacroix, Ludovic, primary, Benisvy, Danielle, primary, Taïeb, David, primary, Bardet, Stéphane, primary, Terroir-Cassou-Mounat, Marie, primary, Anizan, Nadège, primary, Bouvier-Morel, Emilie, primary, Lamartina, Livia, primary, Lion, Georges, primary, Betrian, Sarah, primary, Sajous, Christophe, primary, Schiazza, Aurélie, primary, Garcia, Marie-Eve, primary, Ciappuccini, Renaud, primary, Schlumberger, Martin, primary, Al Ghuzlan, Abir, primary, Godbert, Yann, primary, and Borget, Isabelle, primary

Published
2023
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49. Supplementary Material SM2 from Comprehensive Genome Profiling in Patients With Metastatic Non–Small Cell Lung Cancer: The Precision Medicine Phase II Randomized SAFIR02-Lung/IFCT 1301 Trial

Author

Barlesi, Fabrice, primary, Tomasini, Pascale, primary, Karimi, Maryam, primary, Michiels, Stefan, primary, Raimbourg, Judith, primary, Daniel, Catherine, primary, Janicot, Henri, primary, Madroszyk, Anne, primary, Audigier-Valette, Clarisse, primary, Quoix, Elisabeth, primary, Mazieres, Julien, primary, Moro-Sibilot, Denis, primary, Dansin, Eric, primary, Molinier, Olivier, primary, Morel, Hugues, primary, Pichon, Eric, primary, Cortot, Alexis, primary, Otto, Josiane, primary, Chomy, François, primary, Souquet, Pierre-Jean, primary, Cloarec, Nicolas, primary, Giroux-Leprieur, Etienne, primary, Bieche, Ivan, primary, Lacroix, Ludovic, primary, Boyault, Sandrine, primary, Attignon, Valery, primary, Soubeyran, Isabelle, primary, Morel, Alain, primary, Tran-Dien, Alicia, primary, Jacquet, Alexandra, primary, Dall'Olio, Filippo Gustavo, primary, Jimenez, Marta, primary, Soria, Jean-Charles, primary, and Besse, Benjamin, primary

Published
2023
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50. Supplementary Table TS1 from Comprehensive Genome Profiling in Patients With Metastatic Non–Small Cell Lung Cancer: The Precision Medicine Phase II Randomized SAFIR02-Lung/IFCT 1301 Trial

Author

Barlesi, Fabrice, primary, Tomasini, Pascale, primary, Karimi, Maryam, primary, Michiels, Stefan, primary, Raimbourg, Judith, primary, Daniel, Catherine, primary, Janicot, Henri, primary, Madroszyk, Anne, primary, Audigier-Valette, Clarisse, primary, Quoix, Elisabeth, primary, Mazieres, Julien, primary, Moro-Sibilot, Denis, primary, Dansin, Eric, primary, Molinier, Olivier, primary, Morel, Hugues, primary, Pichon, Eric, primary, Cortot, Alexis, primary, Otto, Josiane, primary, Chomy, François, primary, Souquet, Pierre-Jean, primary, Cloarec, Nicolas, primary, Giroux-Leprieur, Etienne, primary, Bieche, Ivan, primary, Lacroix, Ludovic, primary, Boyault, Sandrine, primary, Attignon, Valery, primary, Soubeyran, Isabelle, primary, Morel, Alain, primary, Tran-Dien, Alicia, primary, Jacquet, Alexandra, primary, Dall'Olio, Filippo Gustavo, primary, Jimenez, Marta, primary, Soria, Jean-Charles, primary, and Besse, Benjamin, primary

Published
2023
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