199 results on '"Laclaustra M"'
Search Results
2. Estándares SEA 2022 para el control global del riesgo cardiovascular
- Author
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Mostaza, Jose Maria, Pintó, Xavier, Armario, Pedro, Masana, Luis, Real, José T., Valdivielso, Pedro, Arrobas-Velilla, Teresa, Baeza-Trinidad, Ramón, Calmarza, Pilar, Cebollada, Jesús, Civera-Andrés, M., Cuende Melero, J.I., Díaz-Díaz, J.L., Fernández Pardo, J., Guijarro, C., Jericó, C., Laclaustra, M., Lahoz, C., López-Miranda, J., Martínez-Hervás, S., Muñiz-Grijalvo, O., Páramo, J.A., Pascual, V., Pedro-Botet, J., Pérez-Martínez, P., Plana, N., Puzo, J., Sánchez Chaparro, M.Á., and Vila, L.
- Published
- 2022
- Full Text
- View/download PDF
3. Contribution of apoe genetic variants to dyslipidemia
- Author
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Bea, A.M., primary, Civeira, F., additional, Marco-Benedí, V., additional, Lamiquiz-Moneo, I., additional, Mateo-Gallego, R., additional, Jarauta, E., additional, Laclaustra, M., additional, and Cenarro, A., additional
- Published
- 2022
- Full Text
- View/download PDF
4. Current causes of death in familial hypercholesterolemia
- Author
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Marco-Benedí, V., primary, Bea, A.M., additional, Cenarro, A., additional, Jarauta, E., additional, Laclaustra, M., additional, and Civeira, F., additional
- Published
- 2022
- Full Text
- View/download PDF
5. Triglyceride metabolism modifies lipoprotein(a) plasma concentration
- Author
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Lamiquiz Moneo, I., primary, Ramos-Cáceres, M., additional, Cenarro, A., additional, Calmarza, P., additional, Marco-Benedí, V., additional, Bea, A.M., additional, Mateo-Gallego, R., additional, Puzo, J., additional, Ordovás, J., additional, Civeira, F., additional, and Laclaustra, M., additional
- Published
- 2022
- Full Text
- View/download PDF
6. The novel Mechanical Ventilator Milano for the COVID-19 pandemic
- Author
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Abba, A, Accorsi, C, Agnes, P, Alessi, E, Amaudruz, P, Annovi, A, Desages, F, Back, S, Badia, C, Bagger, J, Basile, V, Batignani, G, Bayo, A, Bell, B, Beschi, M, Biagini, D, Bianchi, G, Bicelli, S, Bishop, D, Boccali, T, Bombarda, A, Bonfanti, S, Bonivento, W, Bouchard, M, Breviario, M, Brice, S, Brown, R, Calvo-Mozota, J, Camozzi, L, Camozzi, M, Capra, A, Caravati, M, Carlini, M, Ceccanti, A, Celano, B, Cela Ruiz, J, Charette, C, Cogliati, G, Constable, M, Crippa, C, Croci, G, Cudmore, S, Dahl, C, Dal Molin, A, Daley, M, Di Guardo, C, D'Avenio, G, Davignon, O, Del Tutto, M, De Ruiter, J, Devoto, A, Diaz Gomez Maqueo, P, Di Francesco, F, Dossi, M, Druszkiewicz, E, Duma, C, Elliott, E, Farina, D, Fernandes, C, Ferroni, F, Finocchiaro, G, Fiorillo, G, Ford, R, Foti, G, Fournier, R, Franco, D, Fricbergs, C, Gabriele, F, Galbiati, C, Garcia Abia, P, Gargantini, A, Giacomelli, L, Giacomini, F, Giarratana, L, Gillespie, S, Giorgi, D, Girma, T, Gobui, R, Goeldi, D, Golf, F, Gorel, P, Gorini, G, Gramellini, E, Grosso, G, Guescini, F, Guetre, E, Hackman, G, Hadden, T, Hawkins, W, Hayashi, K, Heavey, A, Hersak, G, Hessey, N, Hockin, G, Hudson, K, Ianni, A, Ienzi, C, Ippolito, V, James, C, Jillings, C, Kendziora, C, Khan, S, Kim, E, King, M, King, S, Kittmer, A, Kochanek, I, Kowalkowski, J, Krucken, R, Kushoro, M, Kuula, S, Laclaustra, M, Leblond, G, Lee, L, Lennarz, A, Leyton, M, Li, X, Liimatainen, P, Lim, C, Lindner, T, Lomonaco, T, Lu, P, Lubna, R, Lukhanin, G, Luzon, G, Macdonald, M, Magni, G, Maharaj, R, Manni, S, Mapelli, C, Margetak, P, Martin, L, Martin, S, Martinez, M, Massacret, N, Mcclurg, P, Mcdonald, A, Meazzi, E, Migalla, R, Mohayai, T, Tosatti, L, Monzani, G, Moretti, C, Morrison, B, Mountaniol, M, Muraro, A, Napoli, P, Nati, F, Natzke, C, Noble, A, Norrick, A, Olchanski, K, Ortiz De Solorzano, A, Padula, F, Pallavicini, M, Palumbo, I, Panontin, E, Papini, N, Parmeggiano, L, Parmeggiano, S, Patel, K, Patel, A, Paterno, M, Pellegrino, C, Pelliccione, P, Pesudo, V, Pocar, A, Pope, A, Pordes, S, Prelz, F, Putignano, O, Raaf, J, Ratti, C, Razeti, M, Razeto, A, Reed, D, Refsgaard, J, Reilly, T, Renshaw, A, Retriere, F, Riccobene, E, Rigamonti, D, Rizzi, A, Rode, J, Romualdez, J, Russel, L, Sablone, D, Sala, S, Salomoni, D, Salvo, P, Sandoval, A, Sansoucy, E, Santorelli, R, Savarese, C, Scapparone, E, Schaubel, T, Scorza, S, Settimo, M, Shaw, B, Shawyer, S, Sher, A, Shi, A, Skensved, P, Slutsky, A, Smith, B, Smith, N, Stenzler, A, Straubel, C, Stringari, P, Suchenek, M, Sur, B, Tacchino, S, Takeuchi, L, Tardocchi, M, Tartaglia, R, Thomas, E, Trask, D, Tseng, J, Tseng, L, Vanpagee, L, Vedia, V, Velghe, B, Viel, S, Visioli, A, Viviani, L, Vonica, D, Wada, M, Walter, D, Wang, H, Wang, M, Westerdale, S, Wood, D, Yates, D, Yue, S, Zambrano, V, Abba A., Accorsi C., Agnes P., Alessi E., Amaudruz P., Annovi A., Desages F. A., Back S., Badia C., Bagger J., Basile V., Batignani G., Bayo A., Bell B., Beschi M., Biagini D., Bianchi G., Bicelli S., Bishop D., Boccali T., Bombarda A., Bonfanti S., Bonivento W. M., Bouchard M., Breviario M., Brice S., Brown R., Calvo-Mozota J. M., Camozzi L., Camozzi M., Capra A., Caravati M., Carlini M., Ceccanti A., Celano B., Cela Ruiz J. M., Charette C., Cogliati G., Constable M., Crippa C., Croci G., Cudmore S., Dahl C. E., Dal Molin A., Daley M., Di Guardo C., D'Avenio G., Davignon O., Del Tutto M., De Ruiter J., Devoto A., Diaz Gomez Maqueo P., Di Francesco F., Dossi M., Druszkiewicz E., Duma C., Elliott E., Farina D., Fernandes C., Ferroni F., Finocchiaro G., Fiorillo G., Ford R., Foti G., Fournier R. D., Franco D., Fricbergs C., Gabriele F., Galbiati C., Garcia Abia P., Gargantini A., Giacomelli L., Giacomini F., Giarratana L. S., Gillespie S., Giorgi D., Girma T., Gobui R., Goeldi D., Golf F., Gorel P., Gorini G., Gramellini E., Grosso G., Guescini F., Guetre E., Hackman G., Hadden T., Hawkins W., Hayashi K., Heavey A., Hersak G., Hessey N., Hockin G., Hudson K., Ianni A., Ienzi C., Ippolito V., James C. C., Jillings C., Kendziora C., Khan S., Kim E., King M., King S., Kittmer A., Kochanek I., Kowalkowski J., Krucken R., Kushoro M., Kuula S., Laclaustra M., Leblond G., Lee L., Lennarz A., Leyton M., Li X., Liimatainen P., Lim C., Lindner T., Lomonaco T., Lu P., Lubna R., Lukhanin G. A., Luzon G., Macdonald M., Magni G., Maharaj R., Manni S., Mapelli C., Margetak P., Martin L., Martin S., Martinez M., Massacret N., McClurg P., McDonald A. B., Meazzi E., Migalla R., Mohayai T., Tosatti L. M., Monzani G., Moretti C., Morrison B., Mountaniol M., Muraro A., Napoli P., Nati F., Natzke C. R., Noble A. J., Norrick A., Olchanski K., Ortiz De Solorzano A., Padula F., Pallavicini M., Palumbo I., Panontin E., Papini N., Parmeggiano L., Parmeggiano S., Patel K., Patel A., Paterno M., Pellegrino C., Pelliccione P., Pesudo V., Pocar A., Pope A., Pordes S., Prelz F., Putignano O., Raaf J. L., Ratti C., Razeti M., Razeto A., Reed D., Refsgaard J., Reilly T., Renshaw A., Retriere F., Riccobene E., Rigamonti D., Rizzi A., Rode J., Romualdez J., Russel L., Sablone D., Sala S., Salomoni D., Salvo P., Sandoval A., Sansoucy E., Santorelli R., Savarese C., Scapparone E., Schaubel T., Scorza S., Settimo M., Shaw B., Shawyer S., Sher A., Shi A., Skensved P., Slutsky A., Smith B., Smith N. J. T., Stenzler A., Straubel C., Stringari P., Suchenek M., Sur B., Tacchino S., Takeuchi L., Tardocchi M., Tartaglia R., Thomas E., Trask D., Tseng J., Tseng L., Vanpagee L., Vedia V., Velghe B., Viel S., Visioli A., Viviani L., Vonica D., Wada M., Walter D., Wang H., Wang M. H. L. S., Westerdale S., Wood D., Yates D., Yue S., Zambrano V., Abba, A, Accorsi, C, Agnes, P, Alessi, E, Amaudruz, P, Annovi, A, Desages, F, Back, S, Badia, C, Bagger, J, Basile, V, Batignani, G, Bayo, A, Bell, B, Beschi, M, Biagini, D, Bianchi, G, Bicelli, S, Bishop, D, Boccali, T, Bombarda, A, Bonfanti, S, Bonivento, W, Bouchard, M, Breviario, M, Brice, S, Brown, R, Calvo-Mozota, J, Camozzi, L, Camozzi, M, Capra, A, Caravati, M, Carlini, M, Ceccanti, A, Celano, B, Cela Ruiz, J, Charette, C, Cogliati, G, Constable, M, Crippa, C, Croci, G, Cudmore, S, Dahl, C, Dal Molin, A, Daley, M, Di Guardo, C, D'Avenio, G, Davignon, O, Del Tutto, M, De Ruiter, J, Devoto, A, Diaz Gomez Maqueo, P, Di Francesco, F, Dossi, M, Druszkiewicz, E, Duma, C, Elliott, E, Farina, D, Fernandes, C, Ferroni, F, Finocchiaro, G, Fiorillo, G, Ford, R, Foti, G, Fournier, R, Franco, D, Fricbergs, C, Gabriele, F, Galbiati, C, Garcia Abia, P, Gargantini, A, Giacomelli, L, Giacomini, F, Giarratana, L, Gillespie, S, Giorgi, D, Girma, T, Gobui, R, Goeldi, D, Golf, F, Gorel, P, Gorini, G, Gramellini, E, Grosso, G, Guescini, F, Guetre, E, Hackman, G, Hadden, T, Hawkins, W, Hayashi, K, Heavey, A, Hersak, G, Hessey, N, Hockin, G, Hudson, K, Ianni, A, Ienzi, C, Ippolito, V, James, C, Jillings, C, Kendziora, C, Khan, S, Kim, E, King, M, King, S, Kittmer, A, Kochanek, I, Kowalkowski, J, Krucken, R, Kushoro, M, Kuula, S, Laclaustra, M, Leblond, G, Lee, L, Lennarz, A, Leyton, M, Li, X, Liimatainen, P, Lim, C, Lindner, T, Lomonaco, T, Lu, P, Lubna, R, Lukhanin, G, Luzon, G, Macdonald, M, Magni, G, Maharaj, R, Manni, S, Mapelli, C, Margetak, P, Martin, L, Martin, S, Martinez, M, Massacret, N, Mcclurg, P, Mcdonald, A, Meazzi, E, Migalla, R, Mohayai, T, Tosatti, L, Monzani, G, Moretti, C, Morrison, B, Mountaniol, M, Muraro, A, Napoli, P, Nati, F, Natzke, C, Noble, A, Norrick, A, Olchanski, K, Ortiz De Solorzano, A, Padula, F, Pallavicini, M, Palumbo, I, Panontin, E, Papini, N, Parmeggiano, L, Parmeggiano, S, Patel, K, Patel, A, Paterno, M, Pellegrino, C, Pelliccione, P, Pesudo, V, Pocar, A, Pope, A, Pordes, S, Prelz, F, Putignano, O, Raaf, J, Ratti, C, Razeti, M, Razeto, A, Reed, D, Refsgaard, J, Reilly, T, Renshaw, A, Retriere, F, Riccobene, E, Rigamonti, D, Rizzi, A, Rode, J, Romualdez, J, Russel, L, Sablone, D, Sala, S, Salomoni, D, Salvo, P, Sandoval, A, Sansoucy, E, Santorelli, R, Savarese, C, Scapparone, E, Schaubel, T, Scorza, S, Settimo, M, Shaw, B, Shawyer, S, Sher, A, Shi, A, Skensved, P, Slutsky, A, Smith, B, Smith, N, Stenzler, A, Straubel, C, Stringari, P, Suchenek, M, Sur, B, Tacchino, S, Takeuchi, L, Tardocchi, M, Tartaglia, R, Thomas, E, Trask, D, Tseng, J, Tseng, L, Vanpagee, L, Vedia, V, Velghe, B, Viel, S, Visioli, A, Viviani, L, Vonica, D, Wada, M, Walter, D, Wang, H, Wang, M, Westerdale, S, Wood, D, Yates, D, Yue, S, Zambrano, V, Abba A., Accorsi C., Agnes P., Alessi E., Amaudruz P., Annovi A., Desages F. A., Back S., Badia C., Bagger J., Basile V., Batignani G., Bayo A., Bell B., Beschi M., Biagini D., Bianchi G., Bicelli S., Bishop D., Boccali T., Bombarda A., Bonfanti S., Bonivento W. M., Bouchard M., Breviario M., Brice S., Brown R., Calvo-Mozota J. M., Camozzi L., Camozzi M., Capra A., Caravati M., Carlini M., Ceccanti A., Celano B., Cela Ruiz J. M., Charette C., Cogliati G., Constable M., Crippa C., Croci G., Cudmore S., Dahl C. E., Dal Molin A., Daley M., Di Guardo C., D'Avenio G., Davignon O., Del Tutto M., De Ruiter J., Devoto A., Diaz Gomez Maqueo P., Di Francesco F., Dossi M., Druszkiewicz E., Duma C., Elliott E., Farina D., Fernandes C., Ferroni F., Finocchiaro G., Fiorillo G., Ford R., Foti G., Fournier R. D., Franco D., Fricbergs C., Gabriele F., Galbiati C., Garcia Abia P., Gargantini A., Giacomelli L., Giacomini F., Giarratana L. S., Gillespie S., Giorgi D., Girma T., Gobui R., Goeldi D., Golf F., Gorel P., Gorini G., Gramellini E., Grosso G., Guescini F., Guetre E., Hackman G., Hadden T., Hawkins W., Hayashi K., Heavey A., Hersak G., Hessey N., Hockin G., Hudson K., Ianni A., Ienzi C., Ippolito V., James C. C., Jillings C., Kendziora C., Khan S., Kim E., King M., King S., Kittmer A., Kochanek I., Kowalkowski J., Krucken R., Kushoro M., Kuula S., Laclaustra M., Leblond G., Lee L., Lennarz A., Leyton M., Li X., Liimatainen P., Lim C., Lindner T., Lomonaco T., Lu P., Lubna R., Lukhanin G. A., Luzon G., Macdonald M., Magni G., Maharaj R., Manni S., Mapelli C., Margetak P., Martin L., Martin S., Martinez M., Massacret N., McClurg P., McDonald A. B., Meazzi E., Migalla R., Mohayai T., Tosatti L. M., Monzani G., Moretti C., Morrison B., Mountaniol M., Muraro A., Napoli P., Nati F., Natzke C. R., Noble A. J., Norrick A., Olchanski K., Ortiz De Solorzano A., Padula F., Pallavicini M., Palumbo I., Panontin E., Papini N., Parmeggiano L., Parmeggiano S., Patel K., Patel A., Paterno M., Pellegrino C., Pelliccione P., Pesudo V., Pocar A., Pope A., Pordes S., Prelz F., Putignano O., Raaf J. L., Ratti C., Razeti M., Razeto A., Reed D., Refsgaard J., Reilly T., Renshaw A., Retriere F., Riccobene E., Rigamonti D., Rizzi A., Rode J., Romualdez J., Russel L., Sablone D., Sala S., Salomoni D., Salvo P., Sandoval A., Sansoucy E., Santorelli R., Savarese C., Scapparone E., Schaubel T., Scorza S., Settimo M., Shaw B., Shawyer S., Sher A., Shi A., Skensved P., Slutsky A., Smith B., Smith N. J. T., Stenzler A., Straubel C., Stringari P., Suchenek M., Sur B., Tacchino S., Takeuchi L., Tardocchi M., Tartaglia R., Thomas E., Trask D., Tseng J., Tseng L., Vanpagee L., Vedia V., Velghe B., Viel S., Visioli A., Viviani L., Vonica D., Wada M., Walter D., Wang H., Wang M. H. L. S., Westerdale S., Wood D., Yates D., Yue S., and Zambrano V.
- Abstract
This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world.
- Published
- 2021
7. SEA 2022 Standards for Global Control of Cardiovascular Risk
- Author
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Universitat Rovira i Virgili, Mostaza JM; Pintó X; Armario P; Masana L; Real JT; Valdivielso P; Arrobas-Velilla T; Baeza-Trinidad R; Calmarza P; Cebollada J; Civera-Andrés M; Cuende Melero JI; Díaz-Díaz JL; Fernández Pardo J; Guijarro C; Jericó C; Laclaustra M; Lahoz C; López-Miranda J; Martínez-Hervás S; Muñiz-Grijalvo O; Páramo JA; Pascual V; Pedro-Botet J; Pérez-Martínez P; Plana N; Puzo J; Sánchez Chaparro M; Vila L, Universitat Rovira i Virgili, and Mostaza JM; Pintó X; Armario P; Masana L; Real JT; Valdivielso P; Arrobas-Velilla T; Baeza-Trinidad R; Calmarza P; Cebollada J; Civera-Andrés M; Cuende Melero JI; Díaz-Díaz JL; Fernández Pardo J; Guijarro C; Jericó C; Laclaustra M; Lahoz C; López-Miranda J; Martínez-Hervás S; Muñiz-Grijalvo O; Páramo JA; Pascual V; Pedro-Botet J; Pérez-Martínez P; Plana N; Puzo J; Sánchez Chaparro M; Vila L
- Abstract
One of the objectives of the Spanish Society of Arteriosclerosis is to contribute to better knowledge of vascular disease, its prevention and treatment. It is well known that cardiovascular diseases are the leading cause of death in our country and entail a high degree of disability and health care costs. Arteriosclerosis is a multifactorial disease and therefore its prevention requires a global approach that takes into account the different risk factors with which it is associated. Therefore, this document summarizes the current level of knowledge and includes recommendations and procedures to be followed in patients with established cardiovascular disease or at high vascular risk. Specifically, this document reviews the main symptoms and signs to be evaluated during the clinical visit, the laboratory and imaging procedures to be routinely requested or requested for those in special situations. It also includes vascular risk estimation, the diagnostic criteria of the different entities that are cardiovascular risk factors, and makes general and specific recommendations for the treatment of the different cardiovascular risk factors and their final objectives. Finally, the document includes aspects that are not usually referenced in the literature, such as the organization of a vascular risk consultation.
- Published
- 2022
8. Toxic Metals and Subclinical Atherosclerosis in Carotid, Femoral, and Coronary Vascular Territories: The Aragon Workers Health Study
- Author
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Grau-Perez M, Caballero-Mateos M, Domingo-Relloso A, Navas-Acien A, Gomez-Ariza J, Garcia-Barrera T, Leon-Latre M, Soriano-Gil Z, Jarauta E, Cenarro A, Moreno-Franco B, Laclaustra M, Civeira F, Casasnovas J, Guallar E, and Tellez-Plaza M
- Subjects
inorganic chemicals - Abstract
OBJECTIVE: Studies evaluating the association of metals with subclinical atherosclerosis are mostly limited to carotid arteries. We assessed individual and joint associations of nonessential metals exposure with subclinical atherosclerosis in 3 vascular territories. Approach and Results: One thousand eight hundred seventy-three Aragon Workers Health Study participants had urinary determinations of inorganic arsenic species, barium, cadmium, chromium, antimony, titanium, uranium, vanadium, and tungsten. Plaque presence in carotid and femoral arteries was determined by ultrasound. Coronary Agatston calcium score =1 was determined by computed tomography scan. Median arsenic, barium, cadmium, chromium, antimony, titanium, uranium, vanadium, and tungsten levels were 1.83, 1.98, 0.27, 1.18, 0.05, 9.8, 0.03, 0.66, and 0.23 mug/g creatinine, respectively. The adjusted odds ratio (95% CI) for subclinical atherosclerosis presence in at least one territory was 1.25 (1.03-1.51) for arsenic, 1.67 (1.22-2.29) for cadmium, and 1.26 (1.04-1.52) for titanium. These associations were driven by arsenic and cadmium in carotid, cadmium and titanium in femoral, and titanium in coronary territories and mostly remained after additional adjustment for the other relevant metals. Titanium, cadmium, and antimony also showed positive associations with alternative definitions of increased coronary calcium. Bayesian Kernel Machine Regression analysis simultaneously evaluating metal associations suggested an interaction between arsenic and the joint cadmium-titanium exposure.; CONCLUSIONS: Our results support arsenic and cadmium and identify titanium and potentially antimony as atherosclerosis risk factors. Exposure reduction and mitigation interventions of these metals may decrease cardiovascular risk in individuals without clinical disease.
- Published
- 2022
9. SEA 2022 Standards for Global Control of Cardiovascular Risk
- Author
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Mostaza, Jose Maria, Pintó, Xavier, Armario, Pedro, Masana, Luis, Real, José T, Valdivielso, Pedro, Arrobas-Velilla, Teresa, Baeza-Trinidad, Ramón, Calmarza, Pilar, Cebollada, Jesús, Civera-Andrés, M, Cuende Melero, J I, Díaz-Díaz, J L, Fernández Pardo, J, Guijarro, C, Jericó, C, Laclaustra, M, Lahoz, C, López-Miranda, J, Martínez-Hervás, S, Muñiz-Grijalvo, O, Páramo, J A, Pascual, V, Pedro-Botet, J, Pérez-Martínez, P, Plana, N, Puzo, J, Sánchez Chaparro, M Á, and Vila, L
- Subjects
Arterial hypertension ,Dyslipidaemia ,Arteriosclerosis ,Diabetes ,Smoking ,Tabaquismo ,Fibrilación auricular ,Hipertensión arterial ,Cardiovascular prevention ,Dislipemia ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Risk Factors ,Atrial Fibrillation ,Prevención cardiovascular ,Humans - Abstract
One of the objectives of the Spanish Society of Arteriosclerosis is to contribute to better knowledge of vascular disease, its prevention and treatment. It is well known that cardiovascular diseases are the leading cause of death in our country and entail a high degree of disability and health care costs. Arteriosclerosis is a multifactorial disease and therefore its prevention requires a global approach that takes into account the different risk factors with which it is associated. Therefore, this document summarizes the current level of knowledge and includes recommendations and procedures to be followed in patients with established cardiovascular disease or at high vascular risk. Specifically, this document reviews the main symptoms and signs to be evaluated during the clinical visit, the laboratory and imaging procedures to be routinely requested or requested for those in special situations. It also includes vascular risk estimation, the diagnostic criteria of the different entities that are cardiovascular risk factors, and makes general and specific recommendations for the treatment of the different cardiovascular risk factors and their final objectives. Finally, the document includes aspects that are not usually referenced in the literature, such as the organization of a vascular risk consultation. Copyright © 2021 The Authors. Publicado por Elsevier Espana, S.L.U. All rights reserved.
- Published
- 2021
10. Lipoprotein(a) in heterozygous familial hypercholesterolemias. Influence of the causative gene and type of mutation
- Author
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Marco, V., primary, Cenarro, A., additional, Laclaustra, M., additional, Larrea, A., additional, Jarauta, E., additional, Lamiquiz-Moneo, I., additional, Calmarza, P., additional, Bea, A.M., additional, Martín, C., additional, and Civeira, F., additional
- Published
- 2021
- Full Text
- View/download PDF
11. Non-HDL cholesterol/apolipoprotein B ratio in the diagnosis of dysbetalipoproteinemia
- Author
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Bea, A.M., primary, Cenarro, A., additional, Marco, V., additional, Mateo-Gallego, R., additional, Jarauta, E., additional, Gracia-Rubio, I., additional, Laclaustra, M., additional, and Civeira, F., additional
- Published
- 2021
- Full Text
- View/download PDF
12. Consumption of high-quality carbohydrates is associated with lower prevalence of subclinical atherosclerosis in femoral arteries: The AWHS study.
- Author
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Cabrejas, A. Muñoz, primary, Laclaustra, M., additional, Guallar-Castillón, P., additional, Casasnovas, J.A., additional, Jarauta, E., additional, Sandoval-Insausti, H., additional, Donat-Vargas, C., additional, and Moreno-Franco, B., additional
- Published
- 2021
- Full Text
- View/download PDF
13. High-quality intake of carbohydrates is associated with lower prevalence of subclinical atherosclerosis in femoral arteries: The AWHS study
- Author
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Muñoz-Cabrejas, A., primary, Laclaustra, M., additional, Guallar-Castillón, P., additional, Casasnovas, J.A., additional, Jarauta, E., additional, Sandoval-Insausti, H., additional, Donat-Vargas, C., additional, and Moreno-Franco, B., additional
- Published
- 2021
- Full Text
- View/download PDF
14. The novel Mechanical Ventilator Milano for the COVID-19 pandemic
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Abba, A., primary, Accorsi, C., additional, Agnes, P., additional, Alessi, E., additional, Amaudruz, P., additional, Annovi, A., additional, Desages, F. Ardellier, additional, Back, S., additional, Badia, C., additional, Bagger, J., additional, Basile, V., additional, Batignani, G., additional, Bayo, A., additional, Bell, B., additional, Beschi, M., additional, Biagini, D., additional, Bianchi, G., additional, Bicelli, S., additional, Bishop, D., additional, Boccali, T., additional, Bombarda, A., additional, Bonfanti, S., additional, Bonivento, W. M., additional, Bouchard, M., additional, Breviario, M., additional, Brice, S., additional, Brown, R., additional, Calvo-Mozota, J. M., additional, Camozzi, L., additional, Camozzi, M., additional, Capra, A., additional, Caravati, M., additional, Carlini, M., additional, Ceccanti, A., additional, Celano, B., additional, Cela Ruiz, J. M., additional, Charette, C., additional, Cogliati, G., additional, Constable, M., additional, Crippa, C., additional, Croci, G., additional, Cudmore, S., additional, Dahl, C. E., additional, Dal Molin, A., additional, Daley, M., additional, Di Guardo, C., additional, D'Avenio, G., additional, Davignon, O., additional, Del Tutto, M., additional, De Ruiter, J., additional, Devoto, A., additional, Diaz Gomez Maqueo, P., additional, Di Francesco, F., additional, Dossi, M., additional, Druszkiewicz, E., additional, Duma, C., additional, Elliott, E., additional, Farina, D., additional, Fernandes, C., additional, Ferroni, F., additional, Finocchiaro, G., additional, Fiorillo, G., additional, Ford, R., additional, Foti, G., additional, Fournier, R. D., additional, Franco, D., additional, Fricbergs, C., additional, Gabriele, F., additional, Galbiati, C., additional, Garcia Abia, P., additional, Gargantini, A., additional, Giacomelli, L., additional, Giacomini, F., additional, Giarratana, L. S., additional, Gillespie, S., additional, Giorgi, D., additional, Girma, T., additional, Gobui, R., additional, Goeldi, D., additional, Golf, F., additional, Gorel, P., additional, Gorini, G., additional, Gramellini, E., additional, Grosso, G., additional, Guescini, F., additional, Guetre, E., additional, Hackman, G., additional, Hadden, T., additional, Hawkins, W., additional, Hayashi, K., additional, Heavey, A., additional, Hersak, G., additional, Hessey, N., additional, Hockin, G., additional, Hudson, K., additional, Ianni, A., additional, Ienzi, C., additional, Ippolito, V., additional, James, C. C., additional, Jillings, C., additional, Kendziora, C., additional, Khan, S., additional, Kim, E., additional, King, M., additional, King, S., additional, Kittmer, A., additional, Kochanek, I., additional, Kowalkowski, J., additional, Krücken, R., additional, Kushoro, M., additional, Kuula, S., additional, Laclaustra, M., additional, Leblond, G., additional, Lee, L., additional, Lennarz, A., additional, Leyton, M., additional, Li, X., additional, Liimatainen, P., additional, Lim, C., additional, Lindner, T., additional, Lomonaco, T., additional, Lu, P., additional, Lubna, R., additional, Lukhanin, G. A., additional, Luzón, G., additional, MacDonald, M., additional, Magni, G., additional, Maharaj, R., additional, Manni, S., additional, Mapelli, C., additional, Margetak, P., additional, Martin, L., additional, Martin, S., additional, Martínez, M., additional, Massacret, N., additional, McClurg, P., additional, McDonald, A. B., additional, Meazzi, E., additional, Migalla, R., additional, Mohayai, T., additional, Tosatti, L. M., additional, Monzani, G., additional, Moretti, C., additional, Morrison, B., additional, Mountaniol, M., additional, Muraro, A., additional, Napoli, P., additional, Nati, F., additional, Natzke, C. R., additional, Noble, A. J., additional, Norrick, A., additional, Olchanski, K., additional, Ortiz de Solorzano, A., additional, Padula, F., additional, Pallavicini, M., additional, Palumbo, I., additional, Panontin, E., additional, Papini, N., additional, Parmeggiano, L., additional, Parmeggiano, S., additional, Patel, K., additional, Patel, A., additional, Paterno, M., additional, Pellegrino, C., additional, Pelliccione, P., additional, Pesudo, V., additional, Pocar, A., additional, Pope, A., additional, Pordes, S., additional, Prelz, F., additional, Putignano, O., additional, Raaf, J. L., additional, Ratti, C., additional, Razeti, M., additional, Razeto, A., additional, Reed, D., additional, Refsgaard, J., additional, Reilly, T., additional, Renshaw, A., additional, Retriere, F., additional, Riccobene, E., additional, Rigamonti, D., additional, Rizzi, A., additional, Rode, J., additional, Romualdez, J., additional, Russel, L., additional, Sablone, D., additional, Sala, S., additional, Salomoni, D., additional, Salvo, P., additional, Sandoval, A., additional, Sansoucy, E., additional, Santorelli, R., additional, Savarese, C., additional, Scapparone, E., additional, Schaubel, T., additional, Scorza, S., additional, Settimo, M., additional, Shaw, B., additional, Shawyer, S., additional, Sher, A., additional, Shi, A., additional, Skensved, P., additional, Slutsky, A., additional, Smith, B., additional, Smith, N. J. T., additional, Stenzler, A., additional, Straubel, C., additional, Stringari, P., additional, Suchenek, M., additional, Sur, B., additional, Tacchino, S., additional, Takeuchi, L., additional, Tardocchi, M., additional, Tartaglia, R., additional, Thomas, E., additional, Trask, D., additional, Tseng, J., additional, Tseng, L., additional, VanPagee, L., additional, Vedia, V., additional, Velghe, B., additional, Viel, S., additional, Visioli, A., additional, Viviani, L., additional, Vonica, D., additional, Wada, M., additional, Walter, D., additional, Wang, H., additional, Wang, M. H. L. S., additional, Westerdale, S., additional, Wood, D., additional, Yates, D., additional, Yue, S., additional, and Zambrano, V., additional
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- 2021
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15. Risk of cataract surgery in subjects with heterozygous familial hypercholesterolemia in prolonged treatment with statins
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Benedí, V. Marco, primary, Laclaustra, M., additional, Casado-Dominguez, J.M., additional, Pobo, R. Villa, additional, Mateo-Gallego, R., additional, Sánchez-Hernández, C.R.M., additional, Nuez, M. Blanco, additional, Ortega-Martínez De Victoria, E., additional, Sitges, M., additional, Pedro-Botet, J., additional, Puzo, J., additional, Villarroel, T., additional, and Civeira, F., additional
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- 2020
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16. Selenium status and blood lipids: the cardiovascular risk in young finns study
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Stranges, S., Tabák, A. G., Guallar, E., Rayman, M. P., Akbaraly, T. N., Laclaustra, M., Alfthan, G., Mussalo-Rauhamaa, H., Viikari, J. S. A., Raitakari, O. T., and Kivimäki, M.
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- 2011
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17. Effect of lipid-lowering treatment in cardiovascular disease prevalence in familial hypercholesterolemia
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Universitat Rovira i Virgili, Perez-Calahorra S, Laclaustra M, Marco-Benedí V, Lamiquiz-Moneo I, Pedro-Botet J, Plana N, Sanchez-Hernandez RM, Amor AJ, Almagro F, Fuentes F, Suarez-Tembra M, Civeira F, Dyslipemia Registry of Spanish Arteriosclerosis Society, Universitat Rovira i Virgili, and Perez-Calahorra S, Laclaustra M, Marco-Benedí V, Lamiquiz-Moneo I, Pedro-Botet J, Plana N, Sanchez-Hernandez RM, Amor AJ, Almagro F, Fuentes F, Suarez-Tembra M, Civeira F, Dyslipemia Registry of Spanish Arteriosclerosis Society
- Abstract
The impact on heterozygous familial hypercholesterolemia (HeFH) health led by high-intensity lipid-lowering therapy (HILLT) is unknown, and the question remains if there is still an unacceptably high residual risk to justify treatment with new lipid-lowering drugs.This observational, retrospective, multicenter, national study in Spain, whose information was obtained from a national dyslipemia registry, was designed to establish the current prevalence of cardiovascular disease (CVD) in HeFH and to define the impact of HILLT on CVD in this population. Odds were estimated using several logistic regression models with progressive adjustment.1958 HeFH, mean age 49.3?±?14.3 years, were included in the analysis. At inclusion in the registry, 295 patients (15.1%) had suffered CVD and 164 (55.6%) had suffered the first event before the onset lipid-lowering treatment. Exposition to treatment associated more than ten times lower odds for CVD than in subjects naïve to treatment (OR 0.085, 95% CI 0.063-0.114, p?0.001). A first CVD event after a mean treatment period of 9.1?±?7.2 years occurred in 131 out of 1615 (8.1%) HeFH subjects, and 115 (87.8%) of them were on HILLT.Current prevalence of CVD among HeFH is one third of that reported before the statins era. Early initiation and prolonged lipid-lowering treatment was associated with a reduction in CVD. New cases of CVD, in spite of HILLT, appeared mostly among patients accumulating risk factors and probably they may be considered for further lipid-lowering drugs.Copyright © 2019 Elsevier B.V. All rights reserved.
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- 2019
18. Association Between Snvs In Apob, Apoe, Ldlr, Nr5a2, Pcsk9, Ppargc1a And Srebf2 Genes With Desmosterol Concentrations In Patients With Hypercholesterolemia Without Mutations In Candidate Genes
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Baila-Rueda, L., primary, Lamiquiz-Moneo, I., additional, Bea, A.M., additional, Marco-Benedi, V., additional, Mateo-Gallego, R., additional, Jarauta, E., additional, Laclaustra, M., additional, Cenarro, A., additional, and Civeira, F., additional
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- 2019
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19. Sensitivity Of The Clinical Criteria For Suspected Familial Hypercholesterolemia In The Detection Of Diagnostic Mutations Of The Disease
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Cenarro, A., primary, Lamiquiz-Moneo, I., additional, Bea, A.M., additional, Mateo-Gallego, R., additional, Laclaustra, M., additional, Osaba, L., additional, Martín, C., additional, and Civeira, F., additional
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- 2019
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20. Effect of an alcohol-free beer enriched with isomaltulose and a resistant dextrin on insulin resistance in diabetic patients with overweight or obesity.
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Mateo-Gallego, R., primary, Pérez-Calahorra, S., additional, Lamiquiz-Moneo, I., additional, Marco-Benedí, V., additional, Bea, A.M., additional, Fumanal, A.J., additional, Prieto-Martín, A., additional, Laclaustra, M., additional, Cenarro, A., additional, and Civeira, F., additional
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- 2019
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21. Predictive value of 3d intima-media thickness for coronary calcium score in subjects with intermediate cardiovascular risk
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Jarauta, E., primary, Laclaustra, M., additional, Langarita, R., additional, Marco-Benedi, V., additional, Bea, A., additional, Villa-Pobo, R., additional, Leon-Latre, M., additional, Casasnovas, J.A., additional, and Civeira, F., additional
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- 2018
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22. Association of LP(a) concentration with the variability in the lipid-lowering response of PCSK9 inhibitors
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Marco Benedí, M.V., primary, Perez Calahorra, S., additional, Bea, A.M., additional, Baila Rueda, L., additional, Lamiquiz Moneo, I., additional, Cenarro, A., additional, Jarauta, E., additional, Laclaustra, M., additional, and Civeira, F., additional
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- 2018
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23. Plaque burden in carotid and femoral arteries measured by 3D versus 2D ultrasound and association with coronary calcium in men with intermedian cardiovascular risk
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Jarauta, E., primary, Laclaustra, M., additional, Villa-Pobo, R., additional, Langarita, R., additional, Marco-Benedi, V., additional, Bea, A., additional, Leon-Latre, M., additional, Casasnovas, Ja, additional, and Civeira, F., additional
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- 2018
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24. Metabolic syndrome prevalence is increased with increasing thyroid hormone resistance levels among normothyroid subjects
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Laclaustra, M., primary, Moreno-Franco, B., additional, Mateo-Gallego, R., additional, Perez-Calahorra, S., additional, Lamiquiz-Moneo, I., additional, Marco-Benedi, V., additional, Cenarro, A., additional, Casasnovas, J.A., additional, and Civeira, F., additional
- Published
- 2018
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25. Genetic and environmental factors predictors of the modification of weight in subjects with overweight and obesity
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Lamiquiz-moneo, I., primary, Mateo-Gallego, R., additional, Dehesa-García, B., additional, Bea, A.M., additional, Perez-Calahorra, S., additional, Marco-Benedi, V., additional, Baila-Rueda, L., additional, Laclaustra, M., additional, Cenarro, A., additional, and Civeira, F., additional
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- 2018
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26. Different protein composition of low-calorie diet differently impacts adipokine profile irrespective of weight loss in overweight and obese women
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Mateo-Gallego, R., primary, Lamiquiz-Moneo, I., additional, Perez-Calahorra, S., additional, Marco-Benedí, V., additional, Bea, A.M., additional, Baila-Rueda, L., additional, Laclaustra, M., additional, Peñalvo, J.L., additional, Civeira, F., additional, and Cenarro, A., additional
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- 2018
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27. Two-generation cardiovascular disease prevalence in familial hypercholesterolemia
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Mateo-Gallego, R., primary, Perez-Calahorra, S., additional, Laclaustra, M., additional, Plana, N., additional, Lahoz, C., additional, Pedro-Botet, J., additional, Ascaso, J.F., additional, Belmonte, A. Vila, additional, Valdivielso, P., additional, Brea, Á., additional, and Civeira, F., additional
- Published
- 2016
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28. La velocidad de la onda del pulso en la prevención cardiovascular
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Civeira, F., primary and Laclaustra, M., additional
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- 2016
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29. Lower-normal TSH is associated with better metabolic risk factors: A cross-sectional study on Spanish men
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Laclaustra, M., primary, Hurtado-Roca, Y., additional, Sendin, M., additional, Leon, M., additional, Ledesma, M., additional, Andres, E., additional, Fernandez-Ortiz, A., additional, Guallar, E., additional, Ordovas, J.M., additional, and Casasnovas, J.A., additional
- Published
- 2015
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30. Selenium Status and Blood Lipids: The Cardiovascular Risk in Young Finns Study
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Stranges, S, Tabák, AG, Guallar, E, Rayman, MP, Akbaraly, TN, Laclaustra, M, Alfthan, G, Mussalo-Rauhamaa, H, Viikari, JS, Raitakari, OT, and Kivimäki, M
- Subjects
Male ,Adolescent ,Cholesterol, HDL ,Cholesterol, LDL ,Article ,Selenium ,Cross-Sectional Studies ,Cardiovascular Diseases ,Risk Factors ,Child, Preschool ,Humans ,Female ,Child ,Finland ,Triglycerides ,Follow-Up Studies - Abstract
Stranges S, Tabák AG, Guallar E, Rayman MP, Akbaraly TN, Laclaustra M, Alfthan G, Mussalo-Rauhamaa H, Viikari JSA, Raitakari OT, Kivimäki M (Health Sciences Research Institute, University of Warwick Medical School, Coventry; University College London, London, UK; Semmelweis University Faculty of Medicine, Budapest, Hungary; Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; National Center for Cardiovascular Research (CNIC), Madrid, Spain; University of Surrey, UK; National Institute of Health and Medical Research (Inserm) U888. F-34000 Montpellier, France; National Institute for Health and Welfare, Helsinki, Finland; Hjelt Institute, University of Helsinki, Helsinki; University of Turku and Turku University Hospital, Turku; University of Turku, Turku; Finnish Institute of Occupational Health and University of Helsinki, Helsinki, Finland). Selenium status and blood lipids: the cardiovascular risk in young finns study. J Intern Med 2011; doi: 10.1111/j.1365-2796.2011.02398.x. Background. Concern has been recently raised about possible adverse cardio-metabolic effects of high selenium status, such as increased risks of diabetes and hyperlipidaemia. However, most of the evidence comes from selenium-replete populations such as that of the United States. Objectives. To examine cross-sectional and longitudinal associations of serum selenium with cardiovascular risk factors in Finland where selenium levels were amongst the lowest in the world until the early 1980s before the implementation of a nationwide selenium fertilization programme. Methods. Serum selenium was measured in 1235 young Finns aged 3-18 years at baseline in 1980 (prefertilization) and in a subgroup (N = 262) at the 6-year follow-up (1986, postfertilization). During the 27-year follow-up, serum lipids, blood pressure, body mass index and smoking were assessed five times (1980, 1983, 1986, 2001 and 2007). Results. Mean (±SD) serum selenium concentrations were 74.3 ± 14.0 ng mL(-1) in 1980 and 106.6 ± 12.5 ng mL(-1) in 1986 (average increase 32.3 ng mL(-1) ; 95% CI: 30.3 to 34.3, P
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- 2011
31. Modifications of leg swing related to the probability of being moved
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Castellote, J.M., primary and Laclaustra, M., additional
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- 2015
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32. Prospective Association of High Dietary Selenium Intake with Increased Risk of Type 2 Diabetes in Women: The Ordet Cohort Study
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Stranges, S, Sieri, S, Vinceti, Marco, Grioni, S, Guallar, E, Laclaustra, M, Muti, P, Berrino, F, and Krogh, V.
- Published
- 2010
33. Study of sedentary time definitions and risk of metabolic syndrome in a middle-aged working population: The AWHS cohort
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Moreno-Franco, B., primary, Andrés-Esteban, E.M., additional, Ledesma, M., additional, Laclaustra, M., additional, Peñalvo, J.L., additional, Pocoví, M., additional, Ordovás, J.M., additional, Casasnovas, J.A., additional, and León-Latre, M., additional
- Published
- 2014
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34. Metabolic syndrome and coronary heart disease among Spanish male workers: A case-control study of MESYAS
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Laclaustra, M., primary, Ordoñez, B., additional, Leon, M., additional, Andres, E.M., additional, Cordero, A., additional, Pascual-Calleja, I., additional, Grima, A., additional, Luengo, E., additional, Alegria, E., additional, Pocovi, M., additional, Civeira, F., additional, and Casasnovas-Lenguas, J.A., additional
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- 2012
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35. Abstract: P370 PHYSICAL INACTIVITY INTERACTS WITH AN ENDOTHELIAL LIPASE POLYMORPHISM TO MODULATE HIGH DENSITY LIPOPROTEIN IN THE GOLDN STUDY
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Smith, C, primary, Arnett, D, additional, Tsai, M, additional, Lai, C, additional, Parnell, L, additional, Shen, J, additional, Junyent, M, additional, Laclaustra, M, additional, and Ordovas, J, additional
- Published
- 2009
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36. Serum Selenium and Peripheral Arterial Disease: Results From the National Health and Nutrition Examination Survey, 2003-2004
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Bleys, J., primary, Navas-Acien, A., additional, Laclaustra, M., additional, Pastor-Barriuso, R., additional, Menke, A., additional, Ordovas, J., additional, Stranges, S., additional, and Guallar, E., additional
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- 2009
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37. Prehypertension Is Associated With Insulin Resistance State and Not With an Initial Renal Function ImpairmentA Metabolic Syndrome in Active Subjects in Spain (MESYAS) Registry Substudy
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CORDERO, A, primary, LACLAUSTRA, M, additional, LEON, M, additional, GRIMA, A, additional, CASASNOVAS, J, additional, LUENGO, E, additional, DELRIO, A, additional, FERREIRA, I, additional, and ALEGRIA, E, additional
- Published
- 2006
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38. Mo-P6:385 Familial hypercholesterolemia screening program using a novel DNA-array in Spain
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Alonso, R., primary, Forga, L., additional, Mata, N., additional, Gomez-Enterria, P., additional, Laclaustra, M., additional, Zabala, S., additional, Saenz, P., additional, Castillo, S., additional, Tejedor, D., additional, and Mata, P., additional
- Published
- 2006
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39. A registration-based approach to quantify flow-mediated dilation (FMD) of the brachial artery in ultrasound image sequences
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Frangi, A.F., primary, Laclaustra, M., additional, and Lamata, P., additional
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- 2003
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40. Effectiveness of atorvastatin 10 mg in reaching EAS LDL-c target in secondary prevention
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Serrano, P., primary, González, P., additional, Boudet, M., additional, Ramo, M.J., additional, Laclaustra, M., additional, Casasnovas, J.A., additional, Del Río, A., additional, Díaz, R., additional, Pueyo, C., additional, Hernández, G., additional, and Ferreira, I.J., additional
- Published
- 2000
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41. Higher selenium status is associated with adverse blood lipid profile in British adults.
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Stranges S, Laclaustra M, Ji C, Cappuccio FP, Navas-Acien A, Ordovas JM, Rayman M, Guallar E, Stranges, Saverio, Laclaustra, Martin, Ji, Chen, Cappuccio, Francesco P, Navas-Acien, Ana, Ordovas, Jose M, Rayman, Margaret, and Guallar, Eliseo
- Abstract
Recent findings have raised concern about possible associations of high selenium exposure with diabetes and hyperlipidemia in the US, a population with high selenium status. In the UK, a population with lower selenium status, there is little data on the association of selenium status with cardio-metabolic risk factors in the general population. We examined the association of plasma selenium concentration with blood lipids in a nationally representative sample of British adults. A cross-sectional study was conducted among 1042 white participants (aged 19-64 y) in the 2000-2001 UK National Diet and Nutrition Survey. Plasma selenium was measured by inductively coupled-plasma mass spectrometry. Total and HDL cholesterol were measured in nonfasting plasma samples. Mean plasma selenium concentration was 1.10 +/- 0.19 micromol/L. The multivariate adjusted differences between the highest (> or =1.20 micromol/L) and lowest (<0.98 micromol/L) quartiles of plasma selenium were 0.39 (95% CI 0.18, 0.60) mmol/L for total cholesterol, 0.38 (0.17, 0.59) for non-HDL cholesterol, and 0.01 (-0.05, 0.07) for HDL cholesterol. Higher plasma selenium (i.e., > or =1.20 micromol/L) was associated with increased total and non-HDL cholesterol levels but not with HDL in the UK adult population. These findings raise additional concern about potential adverse cardio-metabolic effects of high selenium status. Randomized and mechanistic evidence is necessary to assess causality and to evaluate the impact of this association on cardiovascular risk. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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42. Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004.
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Laclaustra M, Navas-Acien A, Stranges S, Ordovas JM, and Guallar E
- Abstract
BACKGROUND: Increasing evidence suggests that high selenium levels are associated with diabetes and other cardiometabolic risk factors. OBJECTIVES: We evaluated the association of serum selenium concentrations with fasting plasma glucose, glycosylated hemoglobin levels, and diabetes in the most recently available representative sample of the U.S. population. METHODS: We used a cross-sectional analysis of 917 adults > or = 40 years of age who had a fasting morning blood sample in the National Health and Nutrition Examination Survey 2003-2004. We evaluated the association of serum selenium, measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry, and diabetes, defined as a self-report of current use of hypoglycemic agents or insulin or as fasting plasma glucose > or = 126 mg/dL. RESULTS: Mean serum selenium was 137.1 microg/L. The multivariable adjusted odds ratio [95% confidence interval (CI)] for diabetes comparing the highest quartile of serum selenium (> or = 147 microg/L) with the lowest (< 124 microg/L) was 7.64 (3.34-17.46). The corresponding average differences (95% CI) in fasting plasma glucose and glycosylated hemoglobin were 9.5 mg/dL (3.4-15.6 mg/dL) and 0.30% (0.14-0.46%), respectively. In spline regression models, the prevalence of diabetes as well as glucose and glycosylated hemoglobin levels increased with increasing selenium concentrations up to 160 microg/L. CONCLUSIONS: In U.S. adults, high serum selenium concentrations were associated with higher prevalence of diabetes and higher fasting plasma glucose and glycosylated hemoglobin levels. Given high selenium intake in the U.S. population, further research is needed to determine the role of excess selenium levels in the development or the progression of diabetes. [ABSTRACT FROM AUTHOR]
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- 2009
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43. Estándares SEA 2022 para el control global del riesgo cardiovascular
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Mostaza, J.M., Pintó, X., Armario, P., Masana, L., Real, J.T., Valdivielso, P., Arrobas-Velilla, T., Baeza-Trinidad, R., Calmarza, P., Cebollada, J., Civera-Andrés, M., Melero, J.I. Cuende, Díaz-Díaz, J.L., Fernández Pardo, J., Guijarro, C., Jericó, C., Laclaustra, M., Lahoz, C., López-Miranda, J., Martínez-Hervás, S., Muñiz-Grijalvo, O., Páramo, J.A., Pascual, V., Pedro-Botet, J., Pérez-Martínez, P., Plana, N., Puzo, J., Sánchez Chaparro, M.Á., and Vila, L.
- Abstract
La Sociedad Española de Arteriosclerosis tiene entre sus objetivos contribuir al mayor y mejor conocimiento de la enfermedad vascular, su prevención y su tratamiento. Es de sobra conocido que las enfermedades cardiovasculares son la primera causa de muerte en nuestro país y conllevan además un elevado grado de discapacidad y gasto sanitario. La arteriosclerosis es una enfermedad de causa multifactorial y es por ello que su prevención exige un abordaje global que contemple los distintos factores de riesgo con los que se asocia. Así, este documento resume el nivel actual de conocimientos e incluye recomendaciones y procedimientos a seguir ante el paciente que presenta enfermedad cardiovascular establecida o se encuentra con elevado riesgo vascular. En concreto, este documento revisa los principales síntomas y signos a evaluar durante la visita clínica, los procedimientos de laboratorio y de imagen a solicitar de forma rutinaria o aquellos en situaciones especiales. Igualmente, incluye la estimación del riesgo vascular, los criterios diagnósticos de las distintas entidades que son factores de riesgo cardiovascular, plantea recomendaciones generales y específicas para el tratamiento de los distintos factores de riesgo cardiovascular y sus objetivos finales. Por último, el documento recoge aspectos habitualmente poco referenciados en la literatura como son la organización de una consulta de riesgo vascular.
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- 2021
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44. Presence of low flow-mediated dilation in subjects with low blood pressure
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Laclaustra, M., Kaski, Jc, Masci, P., Alejandro Frangi, Casasnovas, Ja, Ferreira, Ij, and Cia, P.
45. Cardiovascular risk factors and metabolic syndrome associated with subclinical renal failure,Factores de riesgo cardiovascular y síndrome metabólico asociados a la disfunción renal subclínica: Subanálisis del Registro MESYAS
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Alberto Cordero, Laclaustra, M., León, M., Casasnovas, J. A., Grima, A., Nájar, M., Luengo, E., Del Río, A., Ferreira, I., and Alegría, E.
46. Aragon workers’ health study – design and cohort description
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Casasnovas José A, Alcaide Victor, Civeira Fernando, Guallar Eliseo, Ibañez Borja, Borreguero Jesús, Laclaustra Martin, León Montserrat, Peñalvo José, Ordovás José M, Pocovi Miguel, Sanz Ginés, and Fuster Valentín
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Abstract Background Spain, a Mediterranean country with relatively low rates of coronary heart disease, has a high prevalence of traditional cardiovascular risk factors and is experiencing a severe epidemic of overweight/obesity. We designed the Aragon Workers’ Health Study (AWHS) to characterize the factors associated with metabolic abnormalities and subclinical atherosclerosis in a middle aged population in Spain free of clinical cardiovascular disease. The objective of this paper is to describe the study design, aims and baseline characteristics of participants in the AWHS. Methods/Design Longitudinal cohort study based on the annual health exams of 5,400 workers of a car assembly plant in Figueruelas (Zaragoza, Spain). Study participants were recruited during a standardized clinical exam in 2009–2010 (participation rate 95.6%). Study participants will undergo annual clinical exams and laboratory assays, and baseline and triennial collection of biological materials for biobanking and cardiovascular imaging exams (carotid, femoral and abdominal ultrasonography, coronary calcium score, and ankle-arm blood pressure index). Participants will be followed-up for 10 years. Results The average (SD) age, body mass index, and waist circumference were 49.3 (8.7) years, 27.7 (3.6) kg/m2 and 97.2 (9.9) cm, respectively, among males (N = 5,048), and 40.8 (11.6) years, 24.4 (3.8) kg/m2, and 81.9 (9.9) cm, among females (N = 351). The prevalence of overweight, obesity, current smoking, hypertension, hypercholesterolemia, and diabetes were 55.0, 23.1, 37.1, 40.3, 75.0, and 7.4%, respectively, among males, and 23.7, 8.3, 45.0, 12.1, 59.5, and 0.6%, respectively, among females. In the initial 587 study participants who completed all imaging exams (94.5% male), the prevalence of carotid plaque, femoral plaque, coronary calcium score >1 to 100, and coronary calcium score >100 was 30.3, 56.9, 27.0, and 8.8%, respectively. 67.7% of study participants had at least one plaque in the carotid or femoral arteries. Discussion Baseline data from the AWHS show a high prevalence of cardiovascular risk factors and of sublinical atherosclerosis. Follow-up of this cohort will allow the assessment of subclinical atherosclerosis progression and the link of disease progression to traditional and emergent risk factors.
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- 2012
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47. A prospective study of dietary selenium intake and risk of type 2 diabetes
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Laclaustra Martin, Guallar Eliseo, Vinceti Marco, Grioni Sara, Sieri Sabina, Stranges Saverio, Muti Paola, Berrino Franco, and Krogh Vittorio
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Growing evidence raises concern about possible associations of high selenium exposure with diabetes in selenium-replete populations such as the US. In countries with lower selenium status, such as Italy, there is little epidemiological evidence on the association between selenium and diabetes. This study examined the prospective association between dietary selenium intake and risk of type 2 diabetes. Methods The ORDET cohort study comprised a large sample of women from Northern Italy (n = 7,182). Incident type 2 diabetes was defined as a self-report of a physician diagnosis, use of antidiabetic medication, or a hospitalization discharge. Dietary selenium intake was measured by a semi-quantitative food-frequency questionnaire at the baseline examination (1987-1992). Participants were divided in quintiles based on their baseline dietary selenium intake. Results Average selenium intake at baseline was 55.7 μg/day. After a median follow-up of 16 years, 253 women developed diabetes. In multivariate logistic regression analyses, the odds ratio for diabetes comparing the highest to the lowest quintile of selenium intake was 2.39, (95% CI: 1.32, 4.32; P for linear trend = 0.005). The odds ratio for diabetes associated with a 10 μg/d increase in selenium intake was 1.29 (95% CI: 1.10, 1.52). Conclusions In this population, increased dietary selenium intake was associated with an increased risk of type 2 diabetes. These findings raise additional concerns about the association of selenium intake above the Recommended Dietary Allowance (55 μg/day) with diabetes risk.
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- 2010
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48. The novel Mechanical Ventilator Milano for the COVID-19 pandemic
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M. Tardocchi, P. Lu, Silvia Bonfanti, C. Fricbergs, J. M. Cela Ruiz, M. Del Tutto, R. Brown, D. Salomoni, C. Jillings, A. Visioli, A. Abba, B. Smith, P. Stringari, Valerio Ippolito, K. Olchanski, S. Yue, A. Razeto, L. Parmeggiano, M. Beschi, I. Palumbo, C. C. James, M. Daley, Andrea Bombarda, Eugenio Scapparone, T. Boccali, D. Vonica, G. Luzón, E. Panontin, Nigel Hessey, E. Elliott, O. Putignano, R. Maharaj, M. H. L. S. Wang, M. Laclaustra, A. Sher, E. Gramellini, P. Napoli, S. Parmeggiano, E. Meazzi, S. Sala, A. Muraro, T. Girma, D. Trask, A. Lennarz, F. Golf, G. Magni, C. Di Guardo, A. S. Slutsky, C. Lim, B. Shaw, C. Duma, V. Pesudo, S. Gillespie, A. Devoto, E. Guetre, L. Camozzi, B. Bell, C. E. Dahl, M. Dossi, E. Alessi, M. MacDonald, A. J. Noble, F. Ardellier Desages, O. Davignon, B. Morrison, R. D. Fournier, Alberto Annovi, S. Kuula, Elvinia Riccobene, A. Rizzi, G. Hersak, J. Bagger, S. Brice, S. Khan, L. VanPagee, P. Salvo, R. Lubna, A. Bayo, M. Bouchard, J. Romualdez, G. Bianchi, H. Wang, S. Bicelli, T. A. Mohayai, A. Dal Molin, M. Breviario, C. Ienzi, M. Carlini, K. Hayashi, G. Monzani, G. A. Lukhanin, R. J. Ford, D. Yates, B. Velghe, G. Finocchiaro, C. Charette, M.H. Kushoro, E. Sansoucy, D. Reed, Pierre-Andre Amaudruz, A. Pocar, S. Scorza, M. Camozzi, T. Reilly, C. Crippa, S. Pordes, F. Padula, S. Westerdale, C. Straubel, P. Garcia Abia, A. Shi, D. Giorgi, A. Capra, S. Shawyer, S. Martin, F. Prelz, S. Back, D. Sablone, L. Takeuchi, D. Franco, L. Martin, An. Ianni, L. Tseng, P. McClurg, M. I. Martínez, D. Wood, A. Norrick, C. Pellegrino, J. Tseng, C. Ratti, M. Constable, V. Vedia, L. M. Tosatti, L. S. Giarratana, G. Fiorillo, M. Razeti, A. Patel, C. R. Natzke, S. Manni, M. Wada, S. Tacchino, M. Paterno, P. Gorel, P. Diaz Gomez Maqueo, N. Massacret, S. Cudmore, Marco Pallavicini, A. Heavey, Gabriele Croci, E. Kim, B. Celano, G. Batignani, E. Druszkiewicz, A. L. Renshaw, L. Giacomelli, D. Walter, S. Viel, Angelo Gargantini, D. Goeldi, P. Liimatainen, N. J. T. Smith, T. Schaubel, G. Cogliati, G. Foti, C. Mapelli, F. Retriere, Giuseppe Gorini, K. Patel, R. Tartaglia, N. Papini, M. Settimo, P. Pelliccione, P. Skensved, M. Leyton, V. Basile, A. Kittmer, G. D'Avenio, D. Rigamonti, R. Krücken, F. Guescini, F. Giacomini, E. Thomas, K. Hudson, Claudio Moretti, R. Santorelli, G. Hackman, R. Gobui, L. Viviani, C. Savarese, I. Kochanek, R. Migalla, J. Rode, F. Gabriele, D. Farina, F. Ferroni, F. Di Francesco, J. M. Calvo-Mozota, M. Suchenek, G. Hockin, J. Refsgaard, J. Kowalkowski, A. Pope, T. Lomonaco, S. King, Bhaskar Sur, C. L. Kendziora, M. Caravati, A. Ceccanti, W. Hawkins, W. Bonivento, C. Fernandes, G. Leblond, M. Mountaniol, A. B. McDonald, C. Accorsi, A. Stenzler, Federico Nati, V. Zambrano, D. Bishop, M. King, A. Sandoval, X. Li, P. Margetak, P. Agnes, J. L. Raaf, J. De Ruiter, Cristiano Galbiati, Giovanni Grosso, L. Lee, A. Ortiz de Solórzano, T. Hadden, T. Lindner, D. Biagini, L. Russel, C. Badia, Abba, A., Accorsi, C., Agnes, P., Alessi, E., Amaudruz, P., Annovi, A., Desages, F. A., Back, S., Badia, C., Bagger, J., Basile, V., Batignani, G., Bayo, A., Bell, B., Beschi, M., Biagini, D., Bianchi, G., Bicelli, S., Bishop, D., Boccali, T., Bombarda, A., Bonfanti, S., Bonivento, W. M., Bouchard, M., Breviario, M., Brice, S., Brown, R., Calvo-Mozota, J. M., Camozzi, L., Camozzi, M., Capra, A., Caravati, M., Carlini, M., Ceccanti, A., Celano, B., Cela Ruiz, J. M., Charette, C., Cogliati, G., Constable, M., Crippa, C., Croci, G., Cudmore, S., Dahl, C. E., Dal Molin, A., Daley, M., Di Guardo, C., D'Avenio, G., Davignon, O., Del Tutto, M., De Ruiter, J., Devoto, A., Diaz Gomez Maqueo, P., Di Francesco, F., Dossi, M., Druszkiewicz, E., Duma, C., Elliott, E., Farina, D., Fernandes, C., Ferroni, F., Finocchiaro, G., Fiorillo, G., Ford, R., Foti, G., Fournier, R. D., Franco, D., Fricbergs, C., Gabriele, F., Galbiati, C., Garcia Abia, P., Gargantini, A., Giacomelli, L., Giacomini, F., Giarratana, L. S., Gillespie, S., Giorgi, D., Girma, T., Gobui, R., Goeldi, D., Golf, F., Gorel, P., Gorini, G., Gramellini, E., Grosso, G., Guescini, F., Guetre, E., Hackman, G., Hadden, T., Hawkins, W., Hayashi, K., Heavey, A., Hersak, G., Hessey, N., Hockin, G., Hudson, K., Ianni, A., Ienzi, C., Ippolito, V., James, C. C., Jillings, C., Kendziora, C., Khan, S., Kim, E., King, M., King, S., Kittmer, A., Kochanek, I., Kowalkowski, J., Krucken, R., Kushoro, M., Kuula, S., Laclaustra, M., Leblond, G., Lee, L., Lennarz, A., Leyton, M., Li, X., Liimatainen, P., Lim, C., Lindner, T., Lomonaco, T., Lu, P., Lubna, R., Lukhanin, G. A., Luzon, G., Macdonald, M., Magni, G., Maharaj, R., Manni, S., Mapelli, C., Margetak, P., Martin, L., Martin, S., Martinez, M., Massacret, N., Mcclurg, P., Mcdonald, A. B., Meazzi, E., Migalla, R., Mohayai, T., Tosatti, L. M., Monzani, G., Moretti, C., Morrison, B., Mountaniol, M., Muraro, A., Napoli, P., Nati, F., Natzke, C. R., Noble, A. J., Norrick, A., Olchanski, K., Ortiz De Solorzano, A., Padula, F., Pallavicini, M., Palumbo, I., Panontin, E., Papini, N., Parmeggiano, L., Parmeggiano, S., Patel, K., Patel, A., Paterno, M., Pellegrino, C., Pelliccione, P., Pesudo, V., Pocar, A., Pope, A., Pordes, S., Prelz, F., Putignano, O., Raaf, J. L., Ratti, C., Razeti, M., Razeto, A., Reed, D., Refsgaard, J., Reilly, T., Renshaw, A., Retriere, F., Riccobene, E., Rigamonti, D., Rizzi, A., Rode, J., Romualdez, J., Russel, L., Sablone, D., Sala, S., Salomoni, D., Salvo, P., Sandoval, A., Sansoucy, E., Santorelli, R., Savarese, C., Scapparone, E., Schaubel, T., Scorza, S., Settimo, M., Shaw, B., Shawyer, S., Sher, A., Shi, A., Skensved, P., Slutsky, A., Smith, B., Smith, N. J. T., Stenzler, A., Straubel, C., Stringari, P., Suchenek, M., Sur, B., Tacchino, S., Takeuchi, L., Tardocchi, M., Tartaglia, R., Thomas, E., Trask, D., Tseng, J., Tseng, L., Vanpagee, L., Vedia, V., Velghe, B., Viel, S., Visioli, A., Viviani, L., Vonica, D., Wada, M., Walter, D., Wang, H., Wang, M. H. L. S., Westerdale, S., Wood, D., Yates, D., Yue, S., Zambrano, V., AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), École des Mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Abba, A, Accorsi, C, Agnes, P, Alessi, E, Amaudruz, P, Annovi, A, Desages, F, Back, S, Badia, C, Bagger, J, Basile, V, Batignani, G, Bayo, A, Bell, B, Beschi, M, Biagini, D, Bianchi, G, Bicelli, S, Bishop, D, Boccali, T, Bombarda, A, Bonfanti, S, Bonivento, W, Bouchard, M, Breviario, M, Brice, S, Brown, R, Calvo-Mozota, J, Camozzi, L, Camozzi, M, Capra, A, Caravati, M, Carlini, M, Ceccanti, A, Celano, B, Cela Ruiz, J, Charette, C, Cogliati, G, Constable, M, Crippa, C, Croci, G, Cudmore, S, Dahl, C, Dal Molin, A, Daley, M, Di Guardo, C, D'Avenio, G, Davignon, O, Del Tutto, M, De Ruiter, J, Devoto, A, Diaz Gomez Maqueo, P, Di Francesco, F, Dossi, M, Druszkiewicz, E, Duma, C, Elliott, E, Farina, D, Fernandes, C, Ferroni, F, Finocchiaro, G, Fiorillo, G, Ford, R, Foti, G, Fournier, R, Franco, D, Fricbergs, C, Gabriele, F, Galbiati, C, Garcia Abia, P, Gargantini, A, Giacomelli, L, Giacomini, F, Giarratana, L, Gillespie, S, Giorgi, D, Girma, T, Gobui, R, Goeldi, D, Golf, F, Gorel, P, Gorini, G, Gramellini, E, Grosso, G, Guescini, F, Guetre, E, Hackman, G, Hadden, T, Hawkins, W, Hayashi, K, Heavey, A, Hersak, G, Hessey, N, Hockin, G, Hudson, K, Ianni, A, Ienzi, C, Ippolito, V, James, C, Jillings, C, Kendziora, C, Khan, S, Kim, E, King, M, King, S, Kittmer, A, Kochanek, I, Kowalkowski, J, Krucken, R, Kushoro, M, Kuula, S, Laclaustra, M, Leblond, G, Lee, L, Lennarz, A, Leyton, M, Li, X, Liimatainen, P, Lim, C, Lindner, T, Lomonaco, T, Lu, P, Lubna, R, Lukhanin, G, Luzon, G, Macdonald, M, Magni, G, Maharaj, R, Manni, S, Mapelli, C, Margetak, P, Martin, L, Martin, S, Martinez, M, Massacret, N, Mcclurg, P, Mcdonald, A, Meazzi, E, Migalla, R, Mohayai, T, Tosatti, L, Monzani, G, Moretti, C, Morrison, B, Mountaniol, M, Muraro, A, Napoli, P, Nati, F, Natzke, C, Noble, A, Norrick, A, Olchanski, K, Ortiz De Solorzano, A, Padula, F, Pallavicini, M, Palumbo, I, Panontin, E, Papini, N, Parmeggiano, L, Parmeggiano, S, Patel, K, Patel, A, Paterno, M, Pellegrino, C, Pelliccione, P, Pesudo, V, Pocar, A, Pope, A, Pordes, S, Prelz, F, Putignano, O, Raaf, J, Ratti, C, Razeti, M, Razeto, A, Reed, D, Refsgaard, J, Reilly, T, Renshaw, A, Retriere, F, Riccobene, E, Rigamonti, D, Rizzi, A, Rode, J, Romualdez, J, Russel, L, Sablone, D, Sala, S, Salomoni, D, Salvo, P, Sandoval, A, Sansoucy, E, Santorelli, R, Savarese, C, Scapparone, E, Schaubel, T, Scorza, S, Settimo, M, Shaw, B, Shawyer, S, Sher, A, Shi, A, Skensved, P, Slutsky, A, Smith, B, Smith, N, Stenzler, A, Straubel, C, Stringari, P, Suchenek, M, Sur, B, Tacchino, S, Takeuchi, L, Tardocchi, M, Tartaglia, R, Thomas, E, Trask, D, Tseng, J, Tseng, L, Vanpagee, L, Vedia, V, Velghe, B, Viel, S, Visioli, A, Viviani, L, Vonica, D, Wada, M, Walter, D, Wang, H, Wang, M, Westerdale, S, Wood, D, Yates, D, Yue, S, and Zambrano, V
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ventilator ,Emergency Use Authorization ,Coronavirus disease 2019 (COVID-19) ,Fault conditions ,Computational Mechanics ,Certification ,01 natural sciences ,010305 fluids & plasmas ,law.invention ,Mechanical parts ,Food and drug administration ,Compressed oxygen ,Food and Drug Administration ,Health care professionals ,Industrial partners ,Intensive therapy ,Ventilation mode ,Mechanical ventilator ,law ,0103 physical sciences ,Pandemic ,medicine ,010306 general physics ,Fluid Flow and Transfer Processes ,Physics ,[PHYS]Physics [physics] ,Mechanical Engineering ,healthcare ,Articles ,Condensed Matter Physics ,medicine.disease ,3. Good health ,Medical gas supply ,Mechanical Ventilation, COVID-19 Pandemic ,covid-19 ,Mechanics of Materials ,Others ,Ventilation (architecture) ,Medical emergency ,Settore ING-INF/05 - Sistemi di Elaborazione delle Informazioni ,[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph] - Abstract
International audience; This paper presents the Mechanical Ventilator Milano (MVM), a novel intensive therapy mechanical ventilator designed for rapid, large-scale, low-cost production for the COVID-19 pandemic. Free of moving mechanical parts and requiring only a source of compressed oxygen and medical air to operate, the MVM is designed to support the long-term invasive ventilation often required for COVID-19 patients and operates in pressure-regulated ventilation modes, which minimize the risk of furthering lung trauma. The MVM was extensively tested against ISO standards in the laboratory using a breathing simulator, with good agreement between input and measured breathing parameters and performing correctly in response to fault conditions and stability tests. The MVM has obtained Emergency Use Authorization by U.S. Food and Drug Administration (FDA) for use in healthcare settings during the COVID-19 pandemic and Health Canada Medical Device Authorization for Importation or Sale, under Interim Order for Use in Relation to COVID-19. Following these certifications, mass production is ongoing and distribution is under way in several countries. The MVM was designed, tested, prepared for certification, and mass produced in the space of a few months by a unique collaboration of respiratory healthcare professionals and experimental physicists, working with industrial partners, and is an excellent ventilator candidate for this pandemic anywhere in the world
- Published
- 2021
49. Usefulness of triglycerides-to-high-density lipoprotein cholesterol ratio for predicting the first coronary event in men.
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Cordero A, Andrés E, Ordoñez B, León M, Laclaustra M, Grima A, Luengo E, Moreno J, Bes M, Pascual I, Civeira F, Pocoví M, Alegría E, Casasnovas JA, and MEtabolic Syndrome Active Subjects Study Investigators
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- 2009
- Full Text
- View/download PDF
50. Urinary Phosphate and Subclinical Atherosclerosis: The AWHS Study.
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Torrijo-Belanche C, Moreno-Franco B, Laclaustra M, Gimeno-Ruiz S, Calvo-Galiano N, Rey-García J, and Guallar-Castillón P
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- Humans, Male, Middle Aged, Cross-Sectional Studies, Risk Factors, Femoral Artery, Plaque, Atherosclerotic urine, Plaque, Atherosclerotic epidemiology, Prevalence, Adult, Coronary Artery Disease urine, Coronary Artery Disease epidemiology, Coronary Artery Disease etiology, Spain epidemiology, Phosphates urine, Atherosclerosis urine, Atherosclerosis epidemiology
- Abstract
(1) Background: Atherosclerosis is a leading cause of vascular death worldwide. High urinary phosphate has recently been identified as a cardiovascular risk factor, but its role has not been fully established. The aim of this study was to investigate the association between urinary phosphate and subclinical atherosclerosis in the carotid, femoral as well as coronary territories; (2) Methods: We performed a cross-sectional analysis of a sample of 1169 middle-aged men, aged 50.9 years (SD 3.7), without previous cardiovascular disease, belonging to the Aragon Workers Health Study (AWHS). Urinary phosphate was analyzed in urine samples using the Fiske-Subbarow method. The presence of carotid plaque and femoral plaque was assessed by ultrasound and coronary artery calcium score (CACS) by computed tomography. Demographic, anthropometric and clinical data were collected at annual medical examinations. Logistic regression models were used to estimate the prevalence of adjusted atherosclerosis in the different vascular arteries; (3) Results: A significant inverse association was observed between urinary phosphate and subclinical atherosclerosis in the carotid [OR 95% CI 0.69 (0.49-0.99)] and coronary (CACS > 200) [OR 95% CI 0.46 (0.23-0.88)] arteries; however, no statistically significant association was found between urinary phosphate and the presence of atheroma plaques in the femoral territory [OR 1.02 (0.72-1.45)]; (4) Conclusions: In middle-aged men, a higher urinary phosphate concentration is associated with a lower prevalence of subclinical carotid and coronary atherosclerosis compared with those with a lower urinary phosphate concentration.
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- 2024
- Full Text
- View/download PDF
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