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357 results on '"Lacarelle B"'

1. From 3D spheroids to tumor bearing mice: efficacy and distribution studies of trastuzumab-docetaxel immunoliposome in breast cancer

Author

Rodallec A, Sicard G, Giacometti S, Carré M, Pourroy B, Bouquet F, Savina A, Lacarelle B, Ciccolini J, and Fanciullino R

Subjects
docetaxel, trastuzumab, breast cancer, immunoliposome, spheroids, distribution, tumor xenograft, Medicine (General), R5-920
Abstract

Anne Rodallec,1 Guillaume Sicard,1 Sarah Giacometti,1 Manon Carré,1 Bertrand Pourroy,2 Fanny Bouquet,3 Ariel Savina,3 Bruno Lacarelle,1 Joseph Ciccolini,1 Raphaelle Fanciullino1 1SMARTc Unit, Laboratory of Pharmacokinetics and Toxicology UFR Pharmacy, Center for Research on Cancer of Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille University, Marseille, France; 2Pharmacy Department, APHM La Conception, Marseille, France; 3Roche Institute, Boulogne Billancourt, France Purpose: Nanoparticles are of rising interest in cancer research, but in vitro canonical cell monolayer models are not suitable to evaluate their efficacy when prototyping candidates. Here, we developed three-dimensional (3D) spheroid models to test the efficacy of trastuzumab-docetaxel immunoliposomes in breast cancer prior to further testing them in vivo. Materials and methods: Immunoliposomes were synthesized using the standard thin film method and maleimide linker. Two human breast cancer cell lines varying in Her2 expression were tested: Her2+ cells derived from metastatic site: mammary breast MDA-MB-453 and triple-negative MDA-MB-231 cells. 3D spheroids were developed and tested with fluorescence detection to evaluate viability. In vivo efficacy and biodistribution studies were performed on xenograft bearing nude mice using fluorescent and bioluminescent imaging. Results: In vitro, antiproliferative efficacy was dependent upon cell type, size of the spheroids, and treatment scheduling, resulting in subsequent changes between tested conditions and in vivo results. Immunoliposomes performed better than free docetaxel + free trastuzumab and ado-trastuzumab emtansine (T-DM1). On MDA-MB-453 and MDA-MB-231 cell growth was reduced by 76% and 25%, when compared to free docetaxel + free trastuzumab and by 85% and 70% when compared to T-DM1, respectively. In vivo studies showed tumor accumulation ranging from 3% up to 15% of the total administered dose in MDA-MB-453 and MDA-MB-231 bearing mice. When compared to free docetaxel + free trastuzumab, tumor growth was reduced by 89% (MDA-MB-453) and 25% (MDA-MB-231) and reduced by 66% (MDA-MB-453) and 29% (MDA-MB-231) when compared to T-DM1, an observation in line with data collected from 3D spheroids experiments. Conclusion: We demonstrated the predictivity of 3D in vitro models when developing and testing nanoparticles in experimental oncology. In vitro and in vivo data showed efficient drug delivery with higher efficacy and prolonged survival with immunoliposomes when compared to current anti-Her2 breast cancer strategies. Keywords: docetaxel, trastuzumab, breast cancer, immunoliposome, spheroids, distribution, tumor xenograft

Published
2018

2. Docetaxel-trastuzumab stealth immunoliposome: development and in vitro proof of concept studies in breast cancer

Author

Rodallec A, Brunel JM, Giacometti S, Maccario H, Correard F, Mas E, Orneto C, Savina A, Bouquet F, Lacarelle B, Ciccolini J, and Fanciullino R

Subjects
immunoliposomes – biopharmaceutical development –breast cancer – docetaxel - trastuzumab - HER2, Medicine (General), R5-920
Abstract

Anne Rodallec,1 Jean-Michel Brunel,2 Sarah Giacometti,1 Helene Maccario,3 Florian Correard,3 Eric Mas,3 Caroline Orneto,4 Ariel Savina,5 Fanny Bouquet,5 Bruno Lacarelle,1 Joseph Ciccolini,1 Raphaelle Fanciullino11SMARTc Unit, Pharmacokinetics Laboratory, CRCM UMR U1068 CNRS UMR 7258 Aix Marseille Université, Marseille, France; 2CRCM CNRS UMR 7258 Aix Marseille Université, Marseille, France; 3CRO2 UMR S_911 Aix Marseille Université, Marseille, France; 4Biopharmacy Laboratory, Aix Marseille Université, Marseille, France; 5Institut Roche, Boulogne Billancourt Cedex, FranceBackground: Trastuzumab plus docetaxel is a mainstay to treat HER2-positive breast cancers. However, developing nanoparticles could help to improve the efficacy/toxicity balance of this doublet by improving drug trafficking and delivery to tumors. This project aimed to develop an immunoliposome in breast cancer, combining docetaxel encapsulated in a stealth liposome engrafted with trastuzumab, and comparing its performances on human breast cancer cell lines with standard combination of docetaxel plus trastuzumab.Methods: Several strategies to engraft trastuzumab to pegylated liposomes were tested. Immunoliposomes made of natural (antibody nanoconjugate-1 [ANC-1]) and synthetic lipids (ANC-2) were synthesized using standard thin film method and compared in size, morphology, docetaxel encapsulation, trastuzumab engraftment rates and stability. Antiproliferative activity was tested on human breast cancer models ranging from almost negative (MDA-MB-231), positive (MDA-MB-453) to overexpressing (SKBR3) HER2. Finally, cell uptake of ANC-1 was studied by electronic microscopy.Results: ANC-1 showed a greater docetaxel encapsulation rate (73%±6% vs 53%±4%) and longer stability (up to 1 week) as compared with ANC-2. Both ANC presented particle size ≤150 nm and showed similar or higher in vitro antiproliferative activities than standard treatment, ANC-1 performing better than ANC-2. The IC50s for docetaxel combined to free trastuzumab were 8.7±4, 2±0.7 and 6±2 nM with MDA-MB-231, MDA-MB-453 and SKBR3, respectively. The IC50s for ANC-1 were 2.5±1, 1.8±0.6 and 3.4±0.8 nM and for ANC-2 were 1.8±0.3 nM, 2.8±0.8 nM and 6.8±1.8 nM with MDA-MB-231, MDA-MB-453 and SKBR3, respectively. Cellular uptake appeared to depend on HER2 expression, the higher the expression, the higher the uptake.Conclusion: In vitro results suggest that higher antiproliferative efficacy and efficient drug delivery can be achieved in breast cancer models using nanoparticles.Keywords: immunoliposomes, biopharmaceutical development, breast cancer, docetaxel, trastuzumab, HER2

Published
2018

4. First results on ProtoDUNE-SP liquid argon time projection chamber performance from a beam test at the CERN Neutrino Platform

Author

DUNE Collaboration, Abi, B., Abud, A. Abed, Acciarri, R., Acero, M. A., Adamov, G., Adamowski, M., Adams, D., Adrien, P., Adinolfi, M., Ahmad, Z., Ahmed, J., Alion, T., Monsalve, S. Alonso, Alt, C., Anderson, J., Andreopoulos, C., Andrews, M. P., Andrianala, F., Andringa, S., Ankowski, A., Antonova, M., Antusch, S., Aranda-Fernandez, A., Ariga, A., Arnold, L. O., Arroyave, M. A., Asaadi, J., Aurisano, A., Aushev, V., Autiero, D., Azfar, F., Back, H., Back, J. J., Backhouse, C., Baesso, P., Bagby, L., Bajou, R., Balasubramanian, S., Baldi, P., Baller, B., Bambah, B., Barao, F., Barenboim, G., Barker, G. J., Barkhouse, W., Barnes, C., Barr, G., Monarca, J. Barranco, Barros, N., Barrow, J. L., Bashyal, A., Basque, V., Bay, F., Alba, J. L. Bazo, Beacom, J. F., Bechetoille, E., Behera, B., Bellantoni, L., Bellettini, G., Bellini, V., Beltramello, O., Belver, D., Benekos, N., Neves, F. Bento, Berger, J., Berkman, S., Bernardini, P., Berner, R. M., Berns, H., Bertolucci, S., Betancourt, M., Bezawada, Y., Bhattacharjee, M., Bhuyan, B., Biagi, S., Bian, J., Biassoni, M., Biery, K., Bilki, B., Bishai, M., Bitadze, A., Blake, A., Siffert, B. Blanco, Blaszczyk, F. D. M., Blazey, G. C., Blucher, E., Boissevain, J., Bolognesi, S., Bolton, T., Bonesini, M., Bongrand, M., Bonini, F., Booth, A., Booth, C., Bordoni, S., Borkum, A., Boschi, T., Bostan, N., Bour, P., Boyd, S. B., Boyden, D., Bracinik, J., Braga, D., Brailsford, D., Brandt, A., Bremer, J., Brew, C., Brianne, E., Brice, S. J., Brizzolari, C., Bromberg, C., Brooijmans, G., Brooke, J., Bross, A., Brunetti, G., Buchanan, N., Budd, H., Caiulo, D., Calafiura, P., Calcutt, J., Calin, M., Calvez, S., Calvo, E., Camilleri, L., Caminata, A., Campanelli, M., Caratelli, D., Carini, G., Carlus, B., Carniti, P., Terrazas, I. Caro, Carranza, H., Castillo, A., Castromonte, C., Cattadori, C., Cavalier, F., Cavanna, F., Centro, S., Cerati, G., Cervelli, A., Villanueva, A. Cervera, Chalifour, M., Chang, C., Chardonnet, E., Charitonidis, N., Chatterjee, A., Chattopadhyay, S., Chatzidaki, P., Chaves, J., Chen, H., Chen, M., Chen, Y., Cherdack, D., Chi, C., Childress, S., Chiriacescu, A., Cho, K., Choubey, S., Christensen, A., Christian, D., Christodoulou, G., Church, E., Clarke, P., Coan, T. E., Cocco, A. G., Coelho, J. A. B., Conley, E., Conrad, J. M., Convery, M., Corwin, L., Cotte, P., Cremaldi, L., Cremonesi, L., Crespo-Anadón, J. I., Cristaldo, E., Cross, R., Cuesta, C., Cui, Y., Cussans, D., Dabrowski, M., da Motta, H., Peres, L. Da Silva, David, C., David, Q., Davies, G. S., Davini, S., Dawson, J., De, K., De Almeida, R. M., Debbins, P., De Bonis, I., Decowski, M. P., de Gouvêa, A., De Holanda, P. C., Astiz, I. L. De Icaza, Deisting, A., De Jong, P., Delbart, A., Delepine, D., Delgado, M., Dell'Acqua, A., De Lurgio, P., Neto, J. R. T. de Mello, DeMuth, D. M., Dennis, S., Densham, C., Deptuch, G., De Roeck, A., De Romeri, V., De Vries, J. J., Dharmapalan, R., Dias, M., Diaz, F., Díaz, J. S., Di Domizio, S., Di Giulio, L., Ding, P., Di Noto, L., Distefano, C., Diurba, R., Diwan, M., Djurcic, Z., Dokania, N., Dolinski, M. J., Domine, L., Douglas, D., Drake, G., Drielsma, F., Duchesneau, D., Duffy, K., Dunne, P., Durkin, T., Duyang, H., Dvornikov, O., Dwyer, D. A., Dyshkant, A. S., Eads, M., Edmunds, D., Eisch, J., Emery, S., Ereditato, A., Escobar, C. O., Sanchez, L. Escudero, Evans, J. J., Ewart, E., Ezeribe, A. C., Fabre, C., Fahey, K., Falcone, A., Farnese, C., Farzan, Y., Felix, J., Fernandez-Martinez, E., Menendez, P. Fernandez, Ferraro, F., Fields, L., Filkins, A., Filthaut, F., Fitzpatrick, R. S., Flanagan, W., Fleming, B., Flight, R., Fowler, J., Fox, W., Franc, J., Francis, K., Franco, D., Freeman, J., Freestone, J., Fried, J., Friedland, A., Fuess, S., Furic, I., Furmanski, A. P., Gago, A., Gallagher, H., Gallego-Ros, A., Gallice, N., Galymov, V., Gamberini, E., Gamble, T., Gandhi, R., Gandrajula, R., Gao, S., Garcia-Gamez, D., García-Peris, M. Á., Gardiner, S., Gastler, D., Ge, G., Gelli, B., Gendotti, A., Gent, S., Ghorbani-Moghaddam, Z., Gibin, D., Gil-Botella, I., Girerd, C., Giri, A. K., Gnani, D., Gogota, O., Gold, M., Gollapinni, S., Gollwitzer, K., Gomes, R. A., Bermeo, L. V. Gomez, Fajardo, L. S. Gomez, Gonnella, F., Gonzalez-Cuevas, J. A., Goodman, M. C., Goodwin, O., Goswami, S., Gotti, C., Goudzovski, E., Grace, C., Graham, M., Gramellini, E., Gran, R., Granados, E., Grant, A., Grant, C., Gratieri, D., Green, P., Green, S., Greenler, L., Greenwood, M., Greer, J., Griffith, W. C., Groh, M., Grudzinski, J., Grzelak, K., Gu, W., Guarino, V., Guenette, R., Guglielmi, A., Guo, B., Guthikonda, K. K., Gutierrez, R., Guzowski, P., Guzzo, M. M., Gwon, S., Haaf, K., Habig, A., Hackenburg, A., Hadavand, H., Haenni, R., Hahn, A., Haigh, J., Haiston, J., Hamernik, T., Hamilton, P., Han, J., Harder, K., Harris, D. A., Hartnell, J., Hasegawa, T., Hatcher, R., Hazen, E., Heavey, A., Heeger, K. M., Heise, J., Hennessy, K., Henry, S., Morquecho, M. A. Hernandez, Herner, K., Hertel, L., Hesam, A. S., Hewes, V, Higuera, A., Hill, T., Hillier, S. J., Himmel, A., Hoff, J., Hohl, C., Holin, A., Hoppe, E., Horton-Smith, G. A., Hostert, M., Hourlier, A., Howard, B., Howell, R., Hrivnak, J., Huang, J., Hugon, J., Iles, G., Ilic, N., Iliescu, A. M., Illingworth, R., Ioannisian, A., Itay, R., Izmaylov, A., James, E., Jargowsky, B., Jediny, F., Jesùs-Valls, C., Ji, X., Jiang, L., Jiménez, S., Jipa, A., Joglekar, A., Johnson, C., Johnson, R., Jones, B., Jones, S., Jung, C. K., Junk, T., Jwa, Y., Kabirnezhad, M., Kaboth, A., Kadenko, I., Kamiya, F., Karagiorgi, G., Karcher, A., Karolak, M., Karyotakis, Y., Kasai, S., Kasetti, S. P., Kashur, L., Kazaryan, N., Kearns, E., Keener, P., Kelly, K. J., Kemp, E., Kendziora, C., Ketchum, W., Kettell, S. H., Khabibullin, M., Khotjantsev, A., Khvedelidze, A., Kim, D., King, B., Kirby, B., Kirby, M., Klein, J., Koehler, K., Koerner, L. W., Kohn, S., Koller, P. P., Kordosky, M., Kosc, T., Kose, U., Kostelecký, V. A., Kothekar, K., Krennrich, F., Kreslo, I., Kudenko, Y., Kudryavtsev, V. A., Kulagin, S., Kumar, J., Kumar, R., Kuruppu, C., Kus, V., Kutter, T., Lacarelle, B., Lambert, A., Lande, K., Lane, C. E., Lang, K., Langford, T., Lasorak, P., Last, D., Lastoria, C., Laundrie, A., Lawrence, A., Lazanu, I., LaZur, R., Le, T., Learned, J., LeBrun, P., Miotto, G. Lehmann, Lehnert, R., de Oliveira, M. A. Leigui, Leitner, M., Leyton, M., Li, L., Li, S., Li, S. W., Li, T., Li, Y., Liao, H., Lin, C. S., Lin, S., Lister, A., Littlejohn, B. R., Liu, J., Liu, T., Lockwitz, S., Loew, T., Lokajicek, M., Lomidze, I., Long, K., Loo, K., Lorca, D., Lord, T., LoSecco, J. M., Louis, W. C., Luk, K. B., Luo, X., Lurkin, N., Lux, T., Luzio, V. P., MacFarland, D., Machado, A. A., Machado, P., Macias, C. T., Macier, J. R., Maddalena, A., Madigan, P., Magill, S., Mahn, K., Maio, A., Maloney, J. A., Mandrioli, G., Maneira, J., Manenti, L., Manly, S., Mann, A., Manolopoulos, K., Plata, M. Manrique, Marchionni, A., Marciano, W., Marfatia, D., Mariani, C., Maricic, J., Marinho, F., Marino, A. D., Marshak, M., Marshall, C., Marshall, J., Marteau, J., Martin-Albo, J., Martinez, N., Caicedo, D. A. Martinez, Martynenko, S., Mason, K., Mastbaum, A., Masud, M., Matsuno, S., Matthews, J., Mauger, C., Mauri, N., Mavrokoridis, K., Mazza, R., Mazzacane, A., Mazzucato, E., McCluskey, E., McConkey, N., McFarland, K. S., McGrew, C., McNab, A., Mefodiev, A., Mehta, P., Melas, P., Mellinato, M., Mena, O., Menary, S., Mendez, H., Menegolli, A., Meng, G., Messier, M. D., Metcalf, W., Mewes, M., Meyer, H., Miao, T., Michna, G., Miedema, T., Migenda, J., Milincic, R., Miller, W., Mills, J., Milne, C., Mineev, O., Miranda, O. G., Miryala, S., Mishra, C. S., Mishra, S. R., Mislivec, A., Mladenov, D., Mocioiu, I., Moffat, K., Moggi, N., Mohanta, R., Mohayai, T. A., Mokhov, N., Molina, J., Bueno, L. Molina, Montanari, A., Montanari, C., Montanari, D., Zetina, L. M. Montano, Moon, J., Mooney, M., Moor, A., Moreno, D., Morgan, B., Morris, C., Mossey, C., Motuk, E., Moura, C. A., Mousseau, J., Mu, W., Mualem, L., Mueller, J., Muether, M., Mufson, S., Muheim, F., Muir, A., Mulhearn, M., Muramatsu, H., Murphy, S., Musser, J., Nachtman, J., Nagu, S., Nalbandyan, M., Nandakumar, R., Naples, D., Narita, S., Navas-Nicolás, D., Nayak, N., Nebot-Guinot, M., Necib, L., Negishi, K., Nelson, J. K., Nesbit, J., Nessi, M., Newbold, D., Newcomer, M., Newhart, D., Nichol, R., Niner, E., Nishimura, K., Norman, A., Norrick, A., Northrop, R., Novella, P., Nowak, J. A., Oberling, M., Del Campo, A. Olivares, Olivier, A., Onel, Y., Onishchuk, Y., Ott, J., Pagani, L., Pakvasa, S., Palamara, O., Palestini, S., Paley, J. M., Pallavicini, M., Palomares, C., Pantic, E., Paolone, V., Papadimitriou, V., Papaleo, R., Papanestis, A., Paramesvaran, S., Parke, S., Parsa, Z., Parvu, M., Pascoli, S., Pasqualini, L., Pasternak, J., Pater, J., Patrick, C., Patrizii, L., Patterson, R. B., Patton, S. J., Patzak, T., Paudel, A., Paulos, B., Paulucci, L., Pavlovic, Z., Pawloski, G., Payne, D., Pec, V., Peeters, S. J. M., Penichot, Y., Pennacchio, E., Penzo, A., Peres, O. L. G., Perry, J., Pershey, D., Pessina, G., Petrillo, G., Petta, C., Petti, R., Piastra, F., Pickering, L., Pietropaolo, F., Pillow, J., Pinzino, J., Plunkett, R., Poling, R., Pons, X., Poonthottathil, N., Pordes, S., Potekhin, M., Potenza, R., Potukuchi, B. V. K. S., Pozimski, J., Pozzato, M., Prakash, S., Prakash, T., Prince, S., Prior, G., Pugnere, D., Qi, K., Qian, X., Raaf, J. L., Raboanary, R., Radeka, V., Rademacker, J., Radics, B., Rafique, A., Raguzin, E., Rai, M., Rajaoalisoa, M., Rakhno, I., Rakotondramanana, H. T., Rakotondravohitra, L., Ramachers, Y. A., Rameika, R., Delgado, M. A. Ramirez, Ramson, B., Rappoldi, A., Raselli, G., Ratoff, P., Ravat, S., Razafinime, H., Real, J. S., Rebel, B., Redondo, D., Reggiani-Guzzo, M., Rehak, T., Reichenbacher, J., Reitzner, S. D., Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Riccobene, G., Rice, L. C. J., Rielage, K., Rigamonti, A., Rigaut, Y., Rivera, D., Rochester, L., Roda, M., Rodrigues, P., Alonso, M. J. Rodriguez, Rondon, J. Rodriguez, Roeth, A. J., Rogers, H., Rosauro-Alcaraz, S., Rosenthal, M., Rossella, M., Rout, J., Roy, S., Rubbia, A., Rubbia, C., Russell, B., Russell, J., Ruterbories, D., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Salukvadze, G., Samios, N., Sanchez, M. C., Sanders, D. A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schellman, H., Schlabach, P., Schmitz, D., Scholberg, K., Schukraft, A., Segreto, E., Seltskaya, E., Sensenig, J., Seong, I., Sergi, A., Sergiampietri, F., Sgalaberna, D., Shaevitz, M. H., Shafaq, S., Shamma, M., Sharma, H. R., Sharma, R., Shaw, T., Shepherd-Themistocleous, C., Shin, S., Shooltz, D., Shrock, R., Simard, L., Simos, N., Sinclair, J., Sinev, G., Singh, J., Singh, V., Sipos, R., Sippach, F. W., Sirri, G., Sitraka, A., Siyeon, K., Smargianaki, D., Smith, A., Smith, E., Smith, P., Smolik, J., Smy, M., Snopok, P., Nunes, M. Soares, Sobel, H., Soderberg, M., Salinas, C. J. Solano, Söldner-Rembold, S., Solomey, N., Solovov, V., Sondheim, W. E., Sorel, M., Soto-Oton, J., Sousa, A., Soustruznik, K., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J. C., Spurgeon, K., Staley, R., Stancari, M., Stanco, L., Stefan, D., Steiner, H. M., Stewart, J., Stillwell, B., Stock, J., Stocker, F., Stokes, T., Strait, M., Strauss, T., Striganov, S., Stuart, A., Sulej, R., Summers, D., Surdo, A., Susic, V., Suter, L., Sutera, C. M., Svoboda, R., Szczerbinska, B., Szelc, A. M., Talaga, R., Tanaka, H. A., Oregui, B. Tapia, Tapper, A., Tariq, S., Tatar, E., Tayloe, R., Teklu, A. M., Tenti, M., Terao, K., Ternes, C. A., Terranova, F., Testera, G., Thea, A., Thompson, J. L., Thorn, C., Timm, S. C., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W. H., Tsai, Y. T., Tsamalaidze, Z., Tsang, K. V., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M. A., Urheim, J., Usher, T., Vagins, M. R., Vahle, P., Valdiviesso, G. A., Valencia, E., Vallari, Z., Valle, J. W. F., Vallecorsa, S., Van Berg, R., Van de Water, R. G., Forero, D. Vanegas, Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M. R., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, H. W., Yu, H. Z., Yu, J., Yu, Z. Y., Zaki, R., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G. P., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The ProtoDUNE-SP detector is a single-phase liquid argon time projection chamber with an active volume of $7.2\times 6.0\times 6.9$ m$^3$. It is installed at the CERN Neutrino Platform in a specially-constructed beam that delivers charged pions, kaons, protons, muons and electrons with momenta in the range 0.3 GeV$/c$ to 7 GeV/$c$. Beam line instrumentation provides accurate momentum measurements and particle identification. The ProtoDUNE-SP detector is a prototype for the first far detector module of the Deep Underground Neutrino Experiment, and it incorporates full-size components as designed for that module. This paper describes the beam line, the time projection chamber, the photon detectors, the cosmic-ray tagger, the signal processing and particle reconstruction. It presents the first results on ProtoDUNE-SP's performance, including noise and gain measurements, $dE/dx$ calibration for muons, protons, pions and electrons, drift electron lifetime measurements, and photon detector noise, signal sensitivity and time resolution measurements. The measured values meet or exceed the specifications for the DUNE far detector, in several cases by large margins. ProtoDUNE-SP's successful operation starting in 2018 and its production of large samples of high-quality data demonstrate the effectiveness of the single-phase far detector design., Comment: 93 pages, 70 figures

Published
2020
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5. Construction of precision wire readout planes for the Short-Baseline Near Detector (SBND)

Author

Acciarri, R., Adams, C., Andreopoulos, C., Asaadi, J., Babicz, M., Backhouse, C., Badgett, W., Bagby, L. F., Barker, D., Barnes, C., Basharina-Freshville, A., Basque, V., Baxter, A., Bazetto, M. C. Q., Beltramello, O., Betancourt, M., Bhanderi, A., Bhat, A., Bishai, M. R. M., Bitadze, A., Blake, A. S. T., Boissevain, J., Bonifazi, C., Book, J. Y., Brailsford, D., Brandt, A., Bremer, J., Brooks, T., Bullard, B. A., Camilleri, L., Carneiro, M. F., Fernández, R. Castillo, Chalifour, M., Chen, Y., Chen, H., Chisnall, G., Cianci, D., Crespo-Anadón, J. I., Cristaldo, E., Cuesta, C., Astiz, I. L. de Icaza, De Roeck, A., Pereira, G. De Sá, de Souza, G., Dennis, S. R., Di Giulio, L., Dixon, S., Elvin, A., Ereditato, A., Evans, J. J., Ezeribe, A. C., Fabre, C., Farrell, J., Fitzpatrick, R. S., Fleming, B. T., Foppiani, N., Foreman, W., Franco, D., Freestone, J., Furmanski, A. P., Gamble, T., Gao, S., Garcia-Gamez, D., Garman, M. P., Gatti, H. F., Ge, G., Gil-Botella, I., Gollapinni, S., Goodwin, O., Green, P., Griffith, W. C., Guenette, R., Guzowski, P., Hamilton, P., Hentschel, S., Hill, C. M., Holin, A., Holt, S., Hrivnak, J., Huang, E. C., James, C. C., Jones, R. S., Jwa, Y., Karagiorgi, G., Kemp, E., Kim, M. J., Kose, U., Kreslo, I., Kubecki, S., Kudryavtsev, V. A., Lacarelle, B., Langstaff, M. R., Larkin, J., LaZur, R., Lepetic, I., Littlejohn, B. R., Lorca, D., Louis, W. C., Machado, A. A., Malek, M., Mariani, C., Marinho, F., Mastbaum, A., Mavrokoridis, K., McConkey, N., Meddage, V., Mercer, I., Mettler, T., Miller, K., Mistry, K., Mladenov, D., Mogan, A. J., Molina, J., Mooney, M., Mousseau, J., Nessi, M., Ni, S., Northrop, R., Nowak, J., Palamara, O., Palestini, S., Palomares, C., Pandey, V., Pater, J. R., Paulucci, L., Pavlovic, Z., Payne, D., Peres, O. L. G., Peres, O., Piastra, F., Pietropaolo, F., Pimentel, V. L., Pons, X., Putnam, G., Qian, X., Radeka, V., Raguzin, E., Ratoff, P., Ray, H., Rebel, B., Reggiani-Guzzo, M., Resnati, F., Rielage, K., Rigamonti, A., Rivera, D., Roda, M., Ross-Lonergan, M., Scanavini, G., Scarff, A., Schmitz, D. W., Schukraft, A., Segreto, E., Seletskaya, E., Shaevitz, M. H., Sinclair, J., Soares, R., Soderberg, M., Söldner-Rembold, S., Souza, H. V., Spagliardi, F., Spanu, M., Spitz, J., Spooner, N. J. C., Stancari, M., Statter, J., Stenico, G. V., Strauss, T., Sutcliffe, P., Sutton, K., Szelc, A. M., Tang, W., Vidal, J. Tena, Thorn, C., Thornton, R. T., Torretta, D., Toups, M., Touramanis, C., Tripathi, M., Tufanli, S., Tyley, E., Valdiviesso, G. A., Van de Water, R., Weber, M., Wilson, P., Wilson, A., Worcester, M., Worcester, E., Wright, M. H., Wright, N., Yu, B., Yu, J., Zamorano, B., Zani, A., Zennamo, J., and Zhao, M.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The Short-Baseline Near Detector time projection chamber is unique in the design of its charge readout planes. These anode plane assemblies (APAs) have been fabricated and assembled to meet strict accuracy and precision requirements: wire spacing of 3 mm +/- 0.5 mm and wire tension of 7 N +/- 1 N across 3,964 wires per APA, and flatness within 0.5 mm over the 4 m +/- 2.5 m extent of each APA. This paper describes the design, manufacture and assembly of these key detector components, with a focus on the quality assurance at each stage., Comment: 42 pages, 45 figures. Prepared for submission to JINST

Published
2020
Full Text
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16. First results on ProtoDUNE-SP liquid argon time projection chamber performance from a beam test at the CERN Neutrino Platform

Author

Abi, B., primary, Abud, A. Abed, additional, Acciarri, R., additional, Acero, M.A., additional, Adamov, G., additional, Adamowski, M., additional, Adams, D., additional, Adrien, P., additional, Adinolfi, M., additional, Ahmad, Z., additional, Ahmed, J., additional, Alion, T., additional, Monsalve, S. Alonso, additional, Alt, C., additional, Anderson, J., additional, Andreopoulos, C., additional, Andrews, M.P., additional, Andrianala, F., additional, Andringa, S., additional, Ankowski, A., additional, Antonova, M., additional, Antusch, S., additional, Aranda-Fernandez, A., additional, Ariga, A., additional, Arnold, L.O., additional, Arroyave, M.A., additional, Asaadi, J., additional, Aurisano, A., additional, Aushev, V., additional, Autiero, D., additional, Azfar, F., additional, Back, H., additional, Back, J.J., additional, Backhouse, C., additional, Baesso, P., additional, Bagby, L., additional, Bajou, R., additional, Balasubramanian, S., additional, Baldi, P., additional, Bambah, B., additional, Barao, F., additional, Barenboim, G., additional, Barker, G.J., additional, Barkhouse, W., additional, Barnes, C., additional, Barr, G., additional, Monarca, J. Barranco, additional, Barros, N., additional, Barrow, J.L., additional, Bashyal, A., additional, Basque, V., additional, Bay, F., additional, Alba, J.L. Bazo, additional, Beacom, J.F., additional, Bechetoille, E., additional, Behera, B., additional, Bellantoni, L., additional, Bellettini, G., additional, Bellini, V., additional, Beltramello, O., additional, Belver, D., additional, Benekos, N., additional, Neves, F. Bento, additional, Berger, J., additional, Berkman, S., additional, Bernardini, P., additional, Berner, R.M., additional, Berns, H., additional, Bertolucci, S., additional, Betancourt, M., additional, Bezawada, Y., additional, Bhattacharjee, M., additional, Bhuyan, B., additional, Biagi, S., additional, Bian, J., additional, Biassoni, M., additional, Biery, K., additional, Bilki, B., additional, Bishai, M., additional, Bitadze, A., additional, Blake, A., additional, Siffert, B. Blanco, additional, Blaszczyk, F.D. M., additional, Blazey, G.C., additional, Blucher, E., additional, Boissevain, J., additional, Bolognesi, S., additional, Bolton, T., additional, Bonesini, M., additional, Bongrand, M., additional, Bonini, F., additional, Booth, A., additional, Booth, C., additional, Bordoni, S., additional, Borkum, A., additional, Boschi, T., additional, Bostan, N., additional, Bour, P., additional, Boyd, S.B., additional, Boyden, D., additional, Bracinik, J., additional, Braga, D., additional, Brailsford, D., additional, Brandt, A., additional, Bremer, J., additional, Brew, C., additional, Brianne, E., additional, Brice, S.J., additional, Brizzolari, C., additional, Bromberg, C., additional, Brooijmans, G., additional, Brooke, J., additional, Bross, A., additional, Brunetti, G., additional, Buchanan, N., additional, Budd, H., additional, Caiulo, D., additional, Calafiura, P., additional, Calcutt, J., additional, Calin, M., additional, Calvez, S., additional, Calvo, E., additional, Camilleri, L., additional, Caminata, A., additional, Campanelli, M., additional, Caratelli, D., additional, Carini, G., additional, Carlus, B., additional, Carniti, P., additional, Terrazas, I. Caro, additional, Carranza, H., additional, Castillo, A., additional, Castromonte, C., additional, Cattadori, C., additional, Cavalier, F., additional, Cavanna, F., additional, Centro, S., additional, Cerati, G., additional, Cervelli, A., additional, Villanueva, A. Cervera, additional, Chalifour, M., additional, Chang, C., additional, Chardonnet, E., additional, Charitonidis, N., additional, Chatterjee, A., additional, Chattopadhyay, S., additional, Chatzidaki, P., additional, Chaves, J., additional, Chen, H., additional, Chen, M., additional, Chen, Y., additional, Cherdack, D., additional, Chi, C., additional, Childress, S., additional, Chiriacescu, A., additional, Cho, K., additional, Choubey, S., additional, Christensen, A., additional, Christian, D., additional, Christodoulou, G., additional, Church, E., additional, Clarke, P., additional, Coan, T.E., additional, Cocco, A.G., additional, Coelho, J.A. B., additional, Conley, E., additional, Conrad, J.M., additional, Convery, M., additional, Corwin, L., additional, Cotte, P., additional, Cremaldi, L., additional, Cremonesi, L., additional, Crespo-Anadón, J.I., additional, Cristaldo, E., additional, Cross, R., additional, Cuesta, C., additional, Cui, Y., additional, Cussans, D., additional, Dabrowski, M., additional, Motta, H. da, additional, Peres, L. Da Silva, additional, David, C., additional, David, Q., additional, Davies, G.S., additional, Davini, S., additional, Dawson, J., additional, De, K., additional, Almeida, R.M. De, additional, Debbins, P., additional, Bonis, I. De, additional, Decowski, M.P., additional, de Gouvêa, A., additional, Holanda, P.C. De, additional, Astiz, I.L. De Icaza, additional, Deisting, A., additional, Jong, P. De, additional, Delbart, A., additional, Delepine, D., additional, Delgado, M., additional, Dell'Acqua, A., additional, Lurgio, P. De, additional, Neto, J.R. T. de Mello, additional, DeMuth, D.M., additional, Dennis, S., additional, Densham, C., additional, Deptuch, G., additional, Roeck, A. De, additional, Romeri, V. De, additional, Vries, J.J. De, additional, Dharmapalan, R., additional, Dias, M., additional, Diaz, F., additional, Díaz, J.S., additional, Domizio, S. Di, additional, Giulio, L. Di, additional, Ding, P., additional, Noto, L. Di, additional, Distefano, C., additional, Diurba, R., additional, Diwan, M., additional, Djurcic, Z., additional, Dokania, N., additional, Dolinski, M.J., additional, Domine, L., additional, Douglas, D., additional, Drielsma, F., additional, Duchesneau, D., additional, Duffy, K., additional, Dunne, P., additional, Durkin, T., additional, Duyang, H., additional, Dvornikov, O., additional, Dwyer, D.A., additional, Dyshkant, A.S., additional, Eads, M., additional, Edmunds, D., additional, Eisch, J., additional, Emery, S., additional, Ereditato, A., additional, Escobar, C.O., additional, Sanchez, L. Escudero, additional, Evans, J.J., additional, Ewart, E., additional, Ezeribe, A.C., additional, Fabre, C., additional, Fahey, K., additional, Falcone, A., additional, Farnese, C., additional, Farzan, Y., additional, Felix, J., additional, Fernandez-Martinez, E., additional, Menendez, P. Fernandez, additional, Ferraro, F., additional, Fields, L., additional, Filkins, A., additional, Filthaut, F., additional, Fitzpatrick, R.S., additional, Flanagan, W., additional, Fleming, B., additional, Flight, R., additional, Fowler, J., additional, Fox, W., additional, Franc, J., additional, Francis, K., additional, Franco, D., additional, Freeman, J., additional, Freestone, J., additional, Fried, J., additional, Friedland, A., additional, Fuess, S., additional, Furic, I., additional, Furmanski, A.P., additional, Gago, A., additional, Gallagher, H., additional, Gallego-Ros, A., additional, Gallice, N., additional, Galymov, V., additional, Gamberini, E., additional, Gamble, T., additional, Gandhi, R., additional, Gandrajula, R., additional, Gao, S., additional, Garcia-Gamez, D., additional, García-Peris, M. Á., additional, Gardiner, S., additional, Gastler, D., additional, Ge, G., additional, Gelli, B., additional, Gendotti, A., additional, Gent, S., additional, Ghorbani-Moghaddam, Z., additional, Gibin, D., additional, Gil-Botella, I., additional, Girerd, C., additional, Giri, A.K., additional, Gnani, D., additional, Gogota, O., additional, Gold, M., additional, Gollapinni, S., additional, Gollwitzer, K., additional, Gomes, R.A., additional, Bermeo, L.V. Gomez, additional, Fajardo, L.S. Gomez, additional, Gonnella, F., additional, Gonzalez-Cuevas, J.A., additional, Goodman, M.C., additional, Goodwin, O., additional, Goswami, S., additional, Gotti, C., additional, Goudzovski, E., additional, Grace, C., additional, Graham, M., additional, Gramellini, E., additional, Gran, R., additional, Granados, E., additional, Grant, A., additional, Grant, C., additional, Gratieri, D., additional, Green, P., additional, Green, S., additional, Greenler, L., additional, Greenwood, M., additional, Greer, J., additional, Griffith, W.C., additional, Groh, M., additional, Grudzinski, J., additional, Grzelak, K., additional, Gu, W., additional, Guarino, V., additional, Guenette, R., additional, Guglielmi, A., additional, Guo, B., additional, Guthikonda, K.K., additional, Gutierrez, R., additional, Guzowski, P., additional, Guzzo, M.M., additional, Gwon, S., additional, Haaf, K., additional, Habig, A., additional, Hackenburg, A., additional, Hadavand, H., additional, Haenni, R., additional, Hahn, A., additional, Haigh, J., additional, Haiston, J., additional, Hamernik, T., additional, Hamilton, P., additional, Han, J., additional, Harder, K., additional, Harris, D.A., additional, Hartnell, J., additional, Hasegawa, T., additional, Hatcher, R., additional, Hazen, E., additional, Heavey, A., additional, Heeger, K.M., additional, Heise, J., additional, Hennessy, K., additional, Henry, S., additional, Morquecho, M.A. Hernandez, additional, Herner, K., additional, Hertel, L., additional, Hesam, A.S., additional, Hewes, J., additional, Higuera, A., additional, Hill, T., additional, Hillier, S.J., additional, Himmel, A., additional, Hoff, J., additional, Hohl, C., additional, Holin, A., additional, Hoppe, E., additional, Horton-Smith, G.A., additional, Hostert, M., additional, Hourlier, A., additional, Howard, B., additional, Howell, R., additional, Hrivnak, J., additional, Huang, J., additional, Hugon, J., additional, Iles, G., additional, Ilic, N., additional, Iliescu, A.M., additional, Illingworth, R., additional, Ioannisian, A., additional, Itay, R., additional, Izmaylov, A., additional, James, E., additional, Jargowsky, B., additional, Jediny, F., additional, Jesùs-Valls, C., additional, Ji, X., additional, Jiang, L., additional, Jiménez, S., additional, Jipa, A., additional, Joglekar, A., additional, Johnson, C., additional, Johnson, R., additional, Jones, B., additional, Jones, S., additional, Jung, C.K., additional, Junk, T., additional, Jwa, Y., additional, Kabirnezhad, M., additional, Kaboth, A., additional, Kadenko, I., additional, Kamiya, F., additional, Karagiorgi, G., additional, Karcher, A., additional, Karolak, M., additional, Karyotakis, Y., additional, Kasai, S., additional, Kasetti, S.P., additional, Kashur, L., additional, Kazaryan, N., additional, Kearns, E., additional, Keener, P., additional, Kelly, K.J., additional, Kemp, E., additional, Kendziora, C., additional, Ketchum, W., additional, Kettell, S.H., additional, Khabibullin, M., additional, Khotjantsev, A., additional, Khvedelidze, A., additional, Kim, D., additional, King, B., additional, Kirby, B., additional, Kirby, M., additional, Klein, J., additional, Koehler, K., additional, Koerner, L.W., additional, Kohn, S., additional, Koller, P.P., additional, Kordosky, M., additional, Kosc, T., additional, Kose, U., additional, Kostelecký, V.A., additional, Kothekar, K., additional, Krennrich, F., additional, Kreslo, I., additional, Kudenko, Y., additional, Kudryavtsev, V.A., additional, Kulagin, S., additional, Kumar, J., additional, Kumar, R., additional, Kuruppu, C., additional, Kus, V., additional, Kutter, T., additional, Lacarelle, B., additional, Lambert, A., additional, Lande, K., additional, Lane, C.E., additional, Lang, K., additional, Langford, T., additional, Lasorak, P., additional, Last, D., additional, Lastoria, C., additional, Laundrie, A., additional, Lawrence, A., additional, Lazanu, I., additional, LaZur, R., additional, Le, T., additional, Learned, J., additional, LeBrun, P., additional, Miotto, G. Lehmann, additional, Lehnert, R., additional, de Oliveira, M.A. Leigui, additional, Leitner, M., additional, Leyton, M., additional, Li, L., additional, Li, S., additional, Li, S.W., additional, Li, T., additional, Li, Y., additional, Liao, H., additional, Lin, C.S., additional, Lin, S., additional, Lister, A., additional, Littlejohn, B.R., additional, Liu, J., additional, Liu, T., additional, Lockwitz, S., additional, Loew, T., additional, Lokajicek, M., additional, Lomidze, I., additional, Long, K., additional, Loo, K., additional, Lorca, D., additional, Lord, T., additional, LoSecco, J.M., additional, Louis, W.C., additional, Luk, K.B., additional, Luo, X., additional, Lurkin, N., additional, Lux, T., additional, Luzio, V.P., additional, MacFarland, D., additional, Machado, A.A., additional, Machado, P., additional, Macias, C.T., additional, Macier, J.R., additional, Maddalena, A., additional, Madigan, P., additional, Magill, S., additional, Mahn, K., additional, Maio, A., additional, Maloney, J.A., additional, Mandrioli, G., additional, Maneira, J., additional, Manenti, L., additional, Manly, S., additional, Mann, A., additional, Manolopoulos, K., additional, Plata, M. Manrique, additional, Marchionni, A., additional, Marciano, W., additional, Marfatia, D., additional, Mariani, C., additional, Maricic, J., additional, Marinho, F., additional, Marino, A.D., additional, Marshak, M., additional, Marshall, C., additional, Marshall, J., additional, Marteau, J., additional, Martin-Albo, J., additional, Martinez, N., additional, Martinez Caicedo, D.A., additional, Martynenko, S., additional, Mason, K., additional, Mastbaum, A., additional, Masud, M., additional, Matsuno, S., additional, Matthews, J., additional, Mauger, C., additional, Mauri, N., additional, Mavrokoridis, K., additional, Mazza, R., additional, Mazzacane, A., additional, Mazzucato, E., additional, McCluskey, E., additional, McConkey, N., additional, McFarland, K.S., additional, McGrew, C., additional, McNab, A., additional, Mefodiev, A., additional, Mehta, P., additional, Melas, P., additional, Mellinato, M., additional, Mena, O., additional, Menary, S., additional, Mendez, H., additional, Menegolli, A., additional, Meng, G., additional, Messier, M.D., additional, Metcalf, W., additional, Mewes, M., additional, Meyer, H., additional, Miao, T., additional, Michna, G., additional, Miedema, T., additional, Migenda, J., additional, Milincic, R., additional, Miller, W., additional, Mills, J., additional, Milne, C., additional, Mineev, O., additional, Miranda, O.G., additional, Miryala, S., additional, Mishra, C.S., additional, Mishra, S.R., additional, Mislivec, A., additional, Mladenov, D., additional, Mocioiu, I., additional, Moffat, K., additional, Moggi, N., additional, Mohanta, R., additional, Mohayai, T.A., additional, Mokhov, N., additional, Molina, J., additional, Bueno, L. Molina, additional, Montanari, A., additional, Montanari, C., additional, Montanari, D., additional, Zetina, L.M. 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M., additional, Penichot, Y., additional, Pennacchio, E., additional, Penzo, A., additional, Peres, O.L. G., additional, Perry, J., additional, Pershey, D., additional, Pessina, G., additional, Petrillo, G., additional, Petta, C., additional, Petti, R., additional, Piastra, F., additional, Pickering, L., additional, Pietropaolo, F., additional, Pillow, J., additional, Pinzino, J., additional, Plunkett, R., additional, Poling, R., additional, Pons, X., additional, Poonthottathil, N., additional, Pordes, S., additional, Potekhin, M., additional, Potenza, R., additional, Potukuchi, B.V. K.S., additional, Pozimski, J., additional, Pozzato, M., additional, Prakash, S., additional, Prakash, T., additional, Prince, S., additional, Prior, G., additional, Pugnere, D., additional, Qi, K., additional, Qian, X., additional, Raaf, J.L., additional, Raboanary, R., additional, Radeka, V., additional, Rademacker, J., additional, Radics, B., additional, Rafique, A., additional, Raguzin, E., additional, Rai, M., additional, Rajaoalisoa, M., additional, Rakhno, I., additional, Rakotondramanana, H.T., additional, Rakotondravohitra, L., additional, Ramachers, Y.A., additional, Rameika, R., additional, Delgado, M.A. Ramirez, additional, Ramson, B., additional, Rappoldi, A., additional, Raselli, G., additional, Ratoff, P., additional, Ravat, S., additional, Razafinime, H., additional, Real, J.S., additional, Rebel, B., additional, Redondo, D., additional, Reggiani-Guzzo, M., additional, Rehak, T., additional, Reichenbacher, J., additional, Reitzner, S.D., additional, Renshaw, A., additional, Rescia, S., additional, Resnati, F., additional, Reynolds, A., additional, Riccobene, G., additional, Rice, L.C. J., additional, Rielage, K., additional, Rigamonti, A., additional, Rigaut, Y., additional, Rivera, D., additional, Rochester, L., additional, Roda, M., additional, Rodrigues, P., additional, Alonso, M.J. Rodriguez, additional, Rondon, J. Rodriguez, additional, Roeth, A.J., additional, Rogers, H., additional, Rosauro-Alcaraz, S., additional, Rosenthal, M., additional, Rossella, M., additional, Rout, J., additional, Roy, S., additional, Rubbia, A., additional, Rubbia, C., additional, Russell, B., additional, Russell, J., additional, Ruterbories, D., additional, Saakyan, R., additional, Sacerdoti, S., additional, Safford, T., additional, Sahu, N., additional, Sala, P., additional, Salukvadze, G., additional, Samios, N., additional, Sanchez, M.C., additional, Sanders, D.A., additional, Sankey, D., additional, Santana, S., additional, Santos-Maldonado, M., additional, Saoulidou, N., additional, Sapienza, P., additional, Sarasty, C., additional, Sarcevic, I., additional, Savage, G., additional, Savinov, V., additional, Scaramelli, A., additional, Scarff, A., additional, Scarpelli, A., additional, Schellman, H., additional, Schlabach, P., additional, Schmitz, D., additional, Scholberg, K., additional, Schukraft, A., additional, Segreto, E., additional, Seltskaya, E., additional, Sensenig, J., additional, Seong, I., additional, Sergi, A., additional, Sergiampietri, F., additional, Sgalaberna, D., additional, Shaevitz, M.H., additional, Shafaq, S., additional, Shamma, M., additional, Sharma, H.R., additional, Sharma, R., additional, Shaw, T., additional, Shepherd-Themistocleous, C., additional, Shin, S., additional, Shooltz, D., additional, Shrock, R., additional, Simard, L., additional, Simos, N., additional, Sinclair, J., additional, Sinev, G., additional, Singh, J., additional, Singh, V., additional, Sipos, R., additional, Sippach, F.W., additional, Sirri, G., additional, Sitraka, A., additional, Siyeon, K., additional, Smargianaki, D., additional, Smith, A., additional, Smith, E., additional, Smith, P., additional, Smolik, J., additional, Smy, M., additional, Snopok, P., additional, Nunes, M. Soares, additional, Sobel, H., additional, Soderberg, M., additional, Salinas, C.J. Solano, additional, Söldner-Rembold, S., additional, Solomey, N., additional, Solovov, V., additional, Sondheim, W.E., additional, Sorel, M., additional, Soto-Oton, J., additional, Sousa, A., additional, Soustruznik, K., additional, Spagliardi, F., additional, Spanu, M., additional, Spitz, J., additional, Spooner, N.J. C., additional, Spurgeon, K., additional, Staley, R., additional, Stancari, M., additional, Stanco, L., additional, Stefan, D., additional, Steiner, H.M., additional, Stewart, J., additional, Stillwell, B., additional, Stock, J., additional, Stocker, F., additional, Stokes, T., additional, Strait, M., additional, Strauss, T., additional, Striganov, S., additional, Stuart, A., additional, Sulej, R., additional, Summers, D., additional, Surdo, A., additional, Susic, V., additional, Suter, L., additional, Sutera, C.M., additional, Svoboda, R., additional, Szczerbinska, B., additional, Szelc, A.M., additional, Talaga, R., additional, Tanaka, H. A., additional, Oregui, B. Tapia, additional, Tapper, A., additional, Tariq, S., additional, Tatar, E., additional, Tayloe, R., additional, Teklu, A.M., additional, Tenti, M., additional, Terao, K., additional, Ternes, C.A., additional, Terranova, F., additional, Testera, G., additional, Thea, A., additional, Thompson, J.L., additional, Thorn, C., additional, Timm, S.C., additional, Tonazzo, A., additional, Torti, M., additional, Tortola, M., additional, Tortorici, F., additional, Totani, D., additional, Toups, M., additional, Touramanis, C., additional, Trevor, J., additional, Trzaska, W.H., additional, Tsai, Y.T., additional, Tsamalaidze, Z., additional, Tsang, K.V., additional, Tsverava, N., additional, Tufanli, S., additional, Tull, C., additional, Tyley, E., additional, Tzanov, M., additional, Uchida, M.A., additional, Urheim, J., additional, Usher, T., additional, Vagins, M.R., additional, Vahle, P., additional, Valdiviesso, G.A., additional, Valencia, E., additional, Vallari, Z., additional, Valle, J.W. F., additional, Vallecorsa, S., additional, Berg, R. Van, additional, de Water, R.G. Van, additional, Forero, D. Vanegas, additional, Varanini, F., additional, Vargas, D., additional, Varner, G., additional, Vasel, J., additional, Vasseur, G., additional, Vaziri, K., additional, Ventura, S., additional, Verdugo, A., additional, Vergani, S., additional, Vermeulen, M.A., additional, Verzocchi, M., additional, de Souza, H. Vieira, additional, Vignoli, C., additional, Vilela, C., additional, Viren, B., additional, Vrba, T., additional, Wachala, T., additional, Waldron, A.V., additional, Wallbank, M., additional, Wang, H., additional, Wang, J., additional, Wang, Y., additional, Warburton, K., additional, Warner, D., additional, Wascko, M., additional, Waters, D., additional, Watson, A., additional, Weatherly, P., additional, Weber, A., additional, Weber, M., additional, Wei, H., additional, Weinstein, A., additional, Wenman, D., additional, Wetstein, M., additional, While, M.R., additional, White, A., additional, Whitehead, L.H., additional, Whittington, D., additional, Wilking, M.J., additional, Wilkinson, C., additional, Williams, Z., additional, Wilson, F., additional, Wilson, R.J., additional, Wolcott, J., additional, Wongjirad, T., additional, Wood, K., additional, Wood, L., additional, Worcester, E., additional, Worcester, M., additional, Wret, C., additional, Wu, W., additional, Xiao, Y., additional, Yang, G., additional, Yang, T., additional, Yershov, N., additional, Yonehara, K., additional, Young, T., additional, Yu, B., additional, Yu, H.W., additional, Yu, H.Z., additional, Yu, J., additional, Yu, Z.Y., additional, Zaki, R., additional, Zalesak, J., additional, Zambelli, L., additional, Zamorano, B., additional, Zani, A., additional, Zazueta, L., additional, Zeller, G.P., additional, Zennamo, J., additional, Zeug, K., additional, Zhang, C., additional, Zhao, M., additional, Zhivun, E., additional, Zhu, G., additional, Zimmerman, E.D., additional, Zito, M., additional, Zucchelli, S., additional, Zuklin, J., additional, Zutshi, V., additional, and Zwaska, R., additional

Published
2020
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17. Construction of precision wire readout planes for the Short-Baseline Near Detector (SBND)

Author

Acciarri, R., primary, Adams, C., additional, Andreopoulos, C., additional, Asaadi, J., additional, Babicz, M., additional, Backhouse, C., additional, Badgett, W., additional, Bagby, L.F., additional, Barker, D., additional, Barnes, C., additional, Basharina-Freshville, A., additional, Basque, V., additional, Baxter, A., additional, Bazetto, M.C.Q., additional, Beltramello, O., additional, Betancourt, M., additional, Bhanderi, A., additional, Bhat, A., additional, Bishai, M.R.M., additional, Bitadze, A., additional, Blake, A.S.T., additional, Boissevain, J., additional, Bonifazi, C., additional, Book, J.Y., additional, Brailsford, D., additional, Brandt, A., additional, Bremer, J., additional, Brooks, T., additional, Bullard, B.A., additional, Camilleri, L., additional, Carneiro, M.F., additional, Fernández, R. Castillo, additional, Chalifour, M., additional, Chen, Y., additional, Chen, H., additional, Chisnall, G., additional, Cianci, D., additional, Crespo-Anadón, J.I., additional, Cristaldo, E., additional, Cuesta, C., additional, Astiz, I.L. de Icaza, additional, Roeck, A. De, additional, Pereira, G. de Sá, additional, de Souza, G., additional, Dennis, S.R., additional, Giulio, L. Di, additional, Dixon, S., additional, Elvin, A., additional, Ereditato, A., additional, Evans, J.J., additional, Ezeribe, A.C., additional, Fabre, C., additional, Farrell, J., additional, Fitzpatrick, R.S., additional, Fleming, B.T., additional, Foppiani, N., additional, Foreman, W., additional, Franco, D., additional, Freestone, J., additional, Furmanski, A.P., additional, Gamble, T., additional, Gao, S., additional, Garcia-Gamez, D., additional, Garman, M.P., additional, Gatti, H.F., additional, Ge, G., additional, Gil-Botella, I., additional, Gollapinni, S., additional, Goodwin, O., additional, Green, P., additional, Griffith, W.C., additional, Guenette, R., additional, Guzowski, P., additional, Hamilton, P., additional, Hentschel, S., additional, Hill, C.M., additional, Holin, A., additional, Holt, S., additional, Hrivnak, J., additional, Huang, E.C., additional, James, C.C., additional, Ji, J., additional, Jones, R.S., additional, Jwa, Y.-J., additional, Karagiorgi, G., additional, Kemp, E., additional, Kim, M.J., additional, Kose, U., additional, Kreslo, I., additional, Kubecki, S., additional, Kudryavtsev, V.A., additional, Lacarelle, B., additional, Langstaff, M.R., additional, Larkin, J., additional, LaZur, R., additional, Lepetic, I., additional, Littlejohn, B.R., additional, Lorca, D., additional, Louis, W.C., additional, Machado, A.A., additional, Malek, M., additional, Mariani, C., additional, Marinho, F., additional, Mastbaum, A., additional, Mavrokoridis, K., additional, McConkey, N., additional, Meddage, V., additional, Mercer, I., additional, Mettler, T., additional, Miller, K., additional, Mistry, K., additional, Mladenov, D., additional, Mogan, A.J., additional, Molina, J., additional, Mooney, M., additional, Mousseau, J., additional, Nessi, M., additional, Ni, S., additional, Northrop, R., additional, Nowak, J., additional, Palamara, O., additional, Palestini, S., additional, Palomares, C., additional, Pandey, V., additional, Pater, J.R., additional, Paulucci, L., additional, Pavlovic, Z., additional, Payne, D., additional, Peres, O.L.G., additional, Peres, O., additional, Piastra, F., additional, Pietropaolo, F., additional, Pimentel, V.L., additional, Pons, X., additional, Putnam, G., additional, Qian, X., additional, Radeka, V., additional, Raguzin, E., additional, Ratoff, P., additional, Ray, H., additional, Rebel, B., additional, Reggiani-Guzzo, M., additional, Resnati, F., additional, Rielage, K., additional, Rigamonti, A., additional, Rivera, D., additional, Roda, M., additional, Ross-Lonergan, M., additional, Scanavini, G., additional, Scarff, A., additional, Schmitz, D.W., additional, Schukraft, A., additional, Segreto, E., additional, Seletskaya, E., additional, Shaevitz, M.H., additional, Sinclair, J., additional, Soares, R., additional, Soderberg, M., additional, Söldner-Rembold, S., additional, Souza, H.V., additional, Spagliardi, F., additional, Spanu, M., additional, Spitz, J., additional, Spooner, N.J.C., additional, Stancari, M., additional, Statter, J., additional, Stenico, G.V., additional, Strauss, T., additional, Sutcliffe, P., additional, Sutton, K., additional, Szelc, A.M., additional, Tang, W., additional, Vidal, J. Tena, additional, Thorn, C., additional, Thornton, R.T., additional, Torretta, D., additional, Toups, M., additional, Touramanis, C., additional, Tripathi, M., additional, Tufanli, S., additional, Tyley, E., additional, Valdiviesso, G.A., additional, de Water, R. Van, additional, Weber, M., additional, Wilson, P., additional, Wilson, A., additional, Worcester, M., additional, Worcester, E., additional, Wright, M.H., additional, Wright, N., additional, Yu, B., additional, Yu, J., additional, Zamorano, B., additional, Zani, A., additional, Zennamo, J., additional, and Zhao, M., additional

Published
2020
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20. Abstracts of papers and posters advanced activities in pharmaceutical care 24th European Symposium on Clinical Pharmacy

Author

Nahata, M. C., Bootman, J. L., Zadák, Z., Soeters, P. B., Goldberg, Laurence A., Stremetzne, S., Jaehde, U., Streit, M., Kreuser, E. D., Thiel, E., Schunack, W., Calvert, R. T., Feely, M., Chrystyn, H., Mangues M. A., Ginovart G., Moral M. A., Lopes A. P., Farré R., Demestre X., Altirriba O., Kloft, Ch., Beyer, J., Steuer, J., Siegert, W., Bever, J., Bialer, M., Sussan, S., Salach, O. Abu, Danenberg, H. D., Laor, A., Barnett, M. I., Cosslett, A. G., Cohen, J., Marini, P., Bassi, C., Bonzanini, A., Cassani, T., Dalle Ore, G., Mangiante, G., Scroccaro, G., Kaczan, M., Eriksen, J., Toft, B., Jandová, M., Vlček, J., Klemerová, V., Sobotka, L., Ayestarán A., López R., Montoro J. B., Pou L., Estíbalez A., Pascual B., Aumente M. D., Panadero M. D., Caraballo M., Pozo J. C., Perez J. L., Falcão, A. C., Fernández de Gatta, M. M., Dominguez-Gil, A., Caramona, M. M., Lanao, J. M., Fendrich, Z., Zajic, J., Bellés Medall M. D., Casabó Alós V. G., Jiménez Torres N. V., Hervás Botella M. A., Abad Gimeno F. J., Casterá Melchor D. E., Aminian M., Mangues M. A., Clopés A., Branco C., Badell I., Pardo, N., Palací C., Bonal J., Rialp G., Bara B., Nobilis, M., Bláha, V., Havel, E., Květina, J., Brátová, M., Solichová, D., Mullerova, M., Svoboda, D., Pokrajac, M., Miljković, B., Simić, D., Brzaković, B., Galetin, A., Pinheiro, R. L., Carrondo, A. P., Sieradzki, E., Strauss, K., Olejarz, E., Marzec, A., Kaużny, J., Szymura-Oleksiak, J., Wyska, E., Jarosz, B., Kosowicz, I., Fabirkiewicz, K., Cherian, R., Vodoz, A. -L., Imsand, B., Belli, D., Rochat, Th., Müllerová, H., Falcão F., Carvalho A., Pereira T., Fonseca C., Freitas O., Resende M., Parrinha A., Costa M., Pessanha M. A., Ferreira A., Mourão L., Ceia F., Lima, Mendonça, Tavares R., SalesLuis A., Carlos Santos, Pereira, M. E. Araújo, Carmo, J. Alves do, Lacerda, J. M. Forjaz, Morais, J. A., Beaufils, C., Le Duff, M., Zamparutti, P., Assicot, P., Bohor, M., Angelini, B., Lambert, M., Manelli, J. C., Gayte-Sorbier, A., Bongrand, M. C., Timon-David, P., Fiqueira, I. C., Lourenco, R., Silva, P. A., Rodrigues, M. O., Fischer, A., Schorr, W., Radziwill, R., Lihtamo M., Jäppinen A., Tuovinen K., Pekkala M., Nuutinen L., Morató, L., Lorente, L., Muñoz, J., Monges, Ph, Blancard, A., Lacarelle, B., Denis, J. P., Bongrand, M. -C., Penot-Ragon, Ch, Gouin, F., Petitcollot, Nicole, Tinguely, I., Beney, J., Marty, S., Reymond, J. -Ph., Bussels J., Robays H., Litzinger, A., Rohda-Bohler, R., Salek, M. S., Turpin, S., Derby, E., Millar, B., Maggs, C., Santiago L. M., Batel Marques, Cajaraville, G., Tarnés, M. J., Díaz, M. J., Del Pozo, C., Plazaola, A., Vuelta, M., Díaz-Munío, E., Ferrer, A., Lozano, A., Guerra, R., Pontón, J. L., Robays, H., Kint, K., Verstraetep, A., Eini, D. El, Ojala, R. K., Kontra, K. M., Naaranlahti, T. J. P., Martorell M., Oliveras M., Juste C., Lopez M. T., Hidalgo E., Cabañas M. J., Barroso C., Llop, J. M., Rey, M., Diaz-Munio, E., Pastó, L., Tubau, M., Gómez-Bellver, M. J., Rodriguez, J., Gómez, J. M., Gónzalez, M. L., Gol V., Fuentes V., Ramón S., Girona L., Castelló T., Olona M., García L., Girón, C., Monteserín, C., Gonzalez, P., Alberola, C., Feio J. A. L., Pharm D., Batel Marques F. J., Borges Alexandrino M., Salek S., Escoms M. C., Caro I., Ticó N., Hidalgo M., Bruguera R., Jodar R., Dowell, J. M., Davey, P. G., Malek, M., Díaz-Munío, E., Vuelta, M., Pastó, L., Rev, M., Ferrer, I., Llop, J. M., Marti, T., Ibars, M., Delporte, J. P., Ansseau, M., Albert, A., Sibourg, M., Gaspard, O., Deprez, M., Ndougsa, H. M., Poma, M., Tamés, M. J., Macek K., Vlček J., Fendrich Z., Klejna M., Dhillon S., Castro I., Newton M., Zupanets, I. A., Chernyh, V. P., Bezdetko, N. B., Popov, S. B., Velieva, M. N., Babajeya, S. M., Mamedov, Y. D., Mammedov, Y. Dj., Veliev, P. M., Nasudari, A. A., Bandalieva, A. A., Nordbo, S., Smith-Solbakken, M., Myklctun, R., Berge, W., Thormodsen, M., Zupanets, L. A., Kicenko, L. S., Plusch, S. I., Isaev, S. G., Vokrouhlický, L., Souček, R., Kuneš, P., Nývlt, O., Potselueva, L. A., Egorova, S. N., Kadirova, E. A., Ziganshina, L. E., Chaloupka, J., and Genger K.

Published
1995
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26. Tacrolimus drug monitoring during conversion from very high dose Prograf (R) to Advagraf (R) in a kidney transplant recipient

Author

Boschi, C., Legris, T., Bérard, C., Quaranta, S., Moal, V., Daniel, L., Lacarelle, B., Manos, E. S. M. Sampol, COMBE, Isabelle, Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Cytosquelette et Intégration des Signaux du Micro-Environnement Tumoral - UMR 6032 (CISMET), Centre National de la Recherche Scientifique (CNRS)-Université de Provence - Aix-Marseille 1-Université de la Méditerranée - Aix-Marseille 2, Unité de Recherche sur les Maladies Infectieuses Tropicales Emergentes (URMITE), Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Université de la Méditerranée - Aix-Marseille 2-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, and Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2017

27. Modélisation mathématique dans un essai clinique de phase 1 : application dans le traitement des cancers bronchiques non à petites cellules et des mésothéliomes avancés, par vinorelbine orale, selon un schéma métronomique

Author

Barbolosi, M., primary, Imbs, D.C., additional, Tomasini, P., additional, Greillier, L., additional, Galloux, M., additional, Testot-Ferry, A., additional, Garcia, M., additional, Elharrar, X., additional, Pelletier, A., additional, Andre, N., additional, Mascaux, C., additional, Lacarelle, B., additional, El Cheikh, R., additional, Serre, R., additional, Ciccolini, J., additional, Barbolosi, D., additional, and Barlesi, F., additional

Published
2018
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29. Faisabilité d’acclimatation d’une biomasse de bioréacteur à membrane aux effluents d’un service d’oncologie

Author

Hamon, P., Moulin, P., Ercolei, L., Lacarelle, B., Marrot, B., Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), IFP Energies nouvelles (IFPEN), Service d'Entreposage des Matières (SEM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cytosquelette et Intégration des Signaux du Micro-Environnement Tumoral - UMR 6032 (CISMET), Centre National de la Recherche Scientifique (CNRS)-Université de Provence - Aix-Marseille 1-Université de la Méditerranée - Aix-Marseille 2, Constant, Eddy, Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), and Université de la Méditerranée - Aix-Marseille 2-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

National audience; no abstract

Published
2014

30. Oncologic ward wastewater treatment by membrane bioreactor: biomass acclimation and pharmaceutical removal

Author

Hamon, P., Moulin, P., Ercolei, L., Lacarelle, B., Marrot, B., Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), IFP Energies nouvelles (IFPEN), Service d'Entreposage des Matières (SEM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cytosquelette et Intégration des Signaux du Micro-Environnement Tumoral - UMR 6032 (CISMET), Université de la Méditerranée - Aix-Marseille 2-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Constant, Eddy, Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), and Centre National de la Recherche Scientifique (CNRS)-Université de Provence - Aix-Marseille 1-Université de la Méditerranée - Aix-Marseille 2

Subjects
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2014

31. Acclimatation d’une biomasse de bioréacteur à membrane aux effluents d’un service d’oncologie

Author

Hamon, P., Moulin, P., Ercolei, L., Lacarelle, B., Marrot, B., Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Service d'Entreposage des Matières (SEM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cytosquelette et Intégration des Signaux du Micro-Environnement Tumoral - UMR 6032 (CISMET), Université de la Méditerranée - Aix-Marseille 2-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Lavoisier Technique et Documentation, Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS)-Université de Provence - Aix-Marseille 1-Université de la Méditerranée - Aix-Marseille 2, and Constant, Eddy

Subjects
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

National audience; no abstract

Published
2013

32. Acclimation of a biomass of a membrane bioreactor to oncologic ward wastewater

Author

Hamon, P., Moulin, P., Ercolei, L., Lacarelle, B., Marrot, B., Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Service d'Entreposage des Matières (SEM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cytosquelette et Intégration des Signaux du Micro-Environnement Tumoral - UMR 6032 (CISMET), Université de la Méditerranée - Aix-Marseille 2-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), Centre National de la Recherche Scientifique (CNRS)-Université de Provence - Aix-Marseille 1-Université de la Méditerranée - Aix-Marseille 2, and Constant, Eddy

Subjects
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2013

33. Acceleration of clear cell renal cell carcinoma growth in mice following bevacizumab/Avastin treatment: the role of CXCL cytokines

Author

Jérôme Durivault, Gilles Pagès, Negrier S, Jean-Yves Scoazec, Chamorey E, Cindy Serdjebi, Marie A. Jacquin, Mélanie Guyot, Lacarelle B, Simonnet H, Sudaka A, Renaud Grépin, RHODIA RECHERCHES ET TECHNOLOGIES CENTRE DE RECHERCHES ET TECHNOLOGIES D'AUBERVILLIERS, RHODIA RECHERCHES ET TECHNOLOGIES, Biostatistics Unit, Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Probabilités et Modèles Aléatoires (LPMA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Equipe 4, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), and Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Université Pierre et Marie Curie - Paris 6 (UPMC)

Subjects
Vascular Endothelial Growth Factor A, Cancer Research, Angiogenesis Inhibitors, Mice, chemistry.chemical_compound, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, MESH: Animals, MESH: Angiogenesis Inhibitors, 0303 health sciences, MESH: Carcinoma, Renal Cell, Kidney Neoplasms, 3. Good health, Lymphangiogenesis, Bevacizumab, Vascular endothelial growth factor, MESH: Antineoplastic Combined Chemotherapy Protocols, Paclitaxel, 030220 oncology & carcinogenesis, Monoclonal, Female, medicine.drug, Mice, Nude, [SDV.CAN]Life Sciences [q-bio]/Cancer, Biology, Antibodies, Monoclonal, Humanized, 03 medical and health sciences, In vivo, MESH: Cell Proliferation, Genetics, medicine, MESH: Mice, Nude, Animals, Humans, MESH: Paclitaxel, Carcinoma, Renal Cell, Molecular Biology, MESH: Mice, Cell Proliferation, 030304 developmental biology, MESH: Humans, Cell growth, MESH: Vascular Endothelial Growth Factor A, Interleukin-8, medicine.disease, MESH: Interleukin-8, Clear cell renal cell carcinoma, chemistry, MESH: Antibodies, Monoclonal, Humanized, Immunology, Cancer research, MESH: Kidney Neoplasms, MESH: Female, Neoplasm Transplantation, MESH: Neoplasm Transplantation
Abstract

International audience; The anti-VEGF targeted antibody bevacizumab (BVZ) has been approved for treating renal cell carcinomas (RCCs). Although BVZ increases the progression-free survival of patients with metastatic RCC, the effect on overall survival is poor. To gain insight into the limited efficacy of BVZ on overall survival, we analyzed patient samples of RCC for angiogenic factors that may participate in escape from anti-VEGF therapy. Our study shows that the level of vascular endothelial growth factor (VEGF) in tumors was increased compared with normal tissue. The level of interleukin-8/CXCL8, a pro-angiogenic member of the CXCL family of cytokines, was also increased in tumors. These observations gave us a good reason to analyze the combined effects of BVZ and anti-CXCL8 antibodies on tumor growth. Surprisingly, we report that BVZ accelerates the growth of RCC in nude mice with in vivo selection of tumor cells with an increased growth capacity. Downregulation of receptor tyrosine phosphatase-κ, a phosphatase implicated in EGF receptor regulation, may partly explain this phenomenon. Modification of the vascular network and development of lymphatic vessels through VEGF-C production and compensatory production of pro-angiogenic CXCL cytokines were also observed. The apparent normalization of the vascular network prompted us to associate BVZ with the chemotherapeutic agent paclitaxel. While efficient in vitro, paclitaxel did not reverse the anti-VEGF effects in vivo. Anti-CXCL8-targeting antibodies were promising as they decreased intra-tumor VEGF production; decreased the pro-angiogenic CXCL/anti-angiogenic CXCL ratio and did not induce lymphangiogenesis. These observations hold clinical implication as they highlight putative markers implicated in escape from BVZ treatment. They also recommend proceeding with caution in the use of anti-VEGF therapy alone for treatment of RCC.

Published
2012

34. Traitement des effluents hospitaliers d’un service d’oncologie par bioréacteur à membrane : acclimatation de la biomasse et élimination de l’anticancéreux 5-fluorouracile

Author

Hamon, P., Moulin, P., Ercolei, L., Lacarelle, B., Marrot, B., Constant, Eddy, Laboratoire de Mécanique, Modélisation et Procédés Propres (M2P2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Service d'Entreposage des Matières (SEM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cytosquelette et Intégration des Signaux du Micro-Environnement Tumoral - UMR 6032 (CISMET), Université de la Méditerranée - Aix-Marseille 2-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École Centrale de Marseille (ECM)-Aix Marseille Université (AMU), and Centre National de la Recherche Scientifique (CNRS)-Université de Provence - Aix-Marseille 1-Université de la Méditerranée - Aix-Marseille 2

Subjects
[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process Engineering, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2012

35. Study of ethnic differences in distribution of CYP3A5 gene polymorphisms

Author

S Chevalier D Allorge D Lo-Guidice Jm Migot-Nabias F Kenani a Imbenotte M Broly F Lacarelle B Lhermitte M., Quaranta, Cytosquelette et Intégration des Signaux du Micro-Environnement Tumoral - UMR 6032 (CISMET), Université de la Méditerranée - Aix-Marseille 2-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), and Vidalin, Michèle

Subjects
[SDV.BC]Life Sciences [q-bio]/Cellular Biology, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2006

39. EVALUATION OF SACCADIC EYE-MOVEMENTS AS AN OBJECTIVE TEST OF RECOVERY FROM ANESTHESIA

Author

Paut, O., Vercher, Jl, Blin, O., Lacarelle, B., Daniel Mestre, Durand, A., Gauthier, Gm, Camboulives, J., Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Vercher, Jean-Louis, and Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)

Subjects
genetic structures, SACCADIC EYE MOVEMENTS, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, PSYCHOMOTOR TESTS, MIDAZOLAM, RECOVERY
Abstract

International audience; Saccadic eye movements have been previously used to assess residual effect of anaesthetics, but this test is seldom compared to other psychomotor tests. The aim of the present study was to validate saccades as a recovery index in relation to frequently referred subjective and psychometric tests. Eight healthy subjects were tested before and after intra-muscular injection of either placebo or 0.15 mg . kg(-1) of midazolam. Each session consisted of a saccadic rest (recorded by electro-oculography), a choice-reaction-time test (CRT), a subjective state-of-alertness test (11 visual analogic scales) and blood sampling (to monitor midazolam plasma concentration), before and 30 (t30), 60 (t60), 120 (t120), 180 (t180), 240 (t240) minutes after drug administration In the placebo group, there was no change in subjective assessment, saccade characteristics (latency, peak velocity and duration) or CRT results. In the midazolam group, 6 subjective items changed with different time-courses, when compared to baseline: from t30 to t120 (drowsy, in shape, tired, clumsy strong) and at t120 (woolly). Saccade latency and duration were significantly different from 130 to t120 and until t180 for peak velocity. CRT performance was significantly altered From t30 to t120. Midazolam plasma concentration decreased From 177+/-33 ng . ml(-1) at t30 to 47+/-12 ng . ml(-1) at t240. At this latter time, sensorimotor functions returned to the baseline. All subjects fulfilled the clinical conditions for home discharge 4 hours after administration. These results suggest that a saccadic eye movement test is a sensitive and reliable tool for the assessment of residual effect of anaesthetics. This test was found to be more sensitive than CRT test since peak saccadic velocity was the last psychometric parameter to be returned to baseline after midazolam injection. This study also confirms the poor reliability of subjective assessment, as subjects tended to underestimate the alteration of their performance immediately following drug injection.

Published
1995

44. Pharmacoeconomic study in head and neck cancer patients: Impact of prospective DPD deficiency screening with 5-fluorouracil (5-FU) dose tailoring on toxicities-related costs

Author

Mercier, C., primary, Brunet, C., additional, Yang, C., additional, Dupuis, C., additional, Bagarry-Liegey, D., additional, Duflo, S., additional, Giovanni, A., additional, Zanaret, M., additional, Lacarelle, B., additional, Duffaud, F., additional, and Ciccolini, J., additional

Published
2009
Full Text
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48. Amprénavir

Author

Venisse, N., primary, Faux, J., additional, Bouquet, S., additional, and Lacarelle, B., additional

Published
2007
Full Text
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49. Saquinavir

Author

Peytavin, G., primary, Lacarelle, B., additional, and Billaud, E., additional

Published
2007
Full Text
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50. Nelfinavir

Author

Peytavin, G., primary, Lacarelle, B., additional, and Barré, J., additional

Published
2007
Full Text
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