5,366 results on '"Labyrinth Diseases"'
Search Results
2. Deep Phenotyping of Hearing Instability Disorders: Cohort Establishment, Biomarker Identification, Development of Novel Phenotyping Measures, and Discovery of Therapeutic Targets
- Published
- 2024
3. Effect of Peripheral Vestibular Disease Location on Outcomes Following Home-based Virtual Reality Vestibular Therapy (VR-PVD-RCT)
- Author
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Desmond A Nunez, Head, Division of Otolaryngology - Head and Neck Surgery, The University of British Columbia; Staff Otolaryngologist, Vancouver Hospital & Health Sciences Centre
- Published
- 2024
4. Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome
- Author
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University of Aarhus, Aarhus University Hospital, and Louise Hill-Madsen, Medical Doctor
- Published
- 2024
5. Multichannel Vestibular Implant Early Feasibility Study
- Author
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National Institute on Deafness and Other Communication Disorders (NIDCD) and Labyrinth Devices, LLC
- Published
- 2024
6. The Accuracy of Manual BPPV Diagnostics When Using VNG Goggles.
- Author
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Malene Hentze Hansen, Principal Investigator
- Published
- 2024
7. Posturography-assisted Vestibular Retraining for Stable Unilateral Vestibular Deficit
- Author
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Eytan A. David, MD, FRCSC, Clinical Instructor, Dept. of Surgery
- Published
- 2024
8. Comparison of Imaging Quality Between Spectral Photon Counting Computed Tomography (SPCCT) and Dual Energy Computed Tomography (DECT) (SPEQUA)
- Published
- 2024
9. Evaluation of the Diagnostic and Prognostic Efficacy of MRI in Acute Sensorineural Hearing Loss and Ménière's Disease (MRI_SSHL/MD)
- Published
- 2024
10. Effects of Anakinra in Subjects With Corticosteroid-resistant/Intolerant Meniere's Disease and Autoimmune Inner Ear Disease
- Author
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Swedish Orphan Biovitrum
- Published
- 2024
11. Vestibular Implantation to Treat Adult-Onset Bilateral Vestibular Hypofunction
- Author
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National Institute on Deafness and Other Communication Disorders (NIDCD) and Labyrinth Devices, LLC
- Published
- 2024
12. Vestibular Implantation in Older Adults
- Author
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National Institute on Aging (NIA) and Labyrinth Devices, LLC
- Published
- 2024
13. MR imaging of endolymphatic hydrops in Ménière's disease: feasibility at 1.5 T.
- Author
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Ben Lakhal, Amine, Boukriba, Seif, Bechraoui, Rim, Mannoubi, Sondes, and Mizouni, Habiba
- Subjects
VERTIGO ,INNER ear diseases ,MENIERE'S disease ,MAGNETIC resonance imaging ,DESCRIPTIVE statistics ,AUDIOMETRY ,LONGITUDINAL method ,COCHLEA - Abstract
Background: Ménière's disease is a chronic condition of the inner ear that causes vertigo, tinnitus and hearing loss. Its diagnosis relies on clinical criteria that are subjective and pure-tone audiometry results that are not specific. Its pathological substrate is endolymphatic hydrops. Its imaging was recently made possible by the late-enhanced 3D FLAIR sequence. This technique was primarily tested on 3 T. Our objective was to prove its feasibility using a 1.5 T magnet. Methods: We conducted a prospective study including 30 patients who fulfilled the Bárány society criteria for Ménière's disease. We performed the late-enhanced 3D FLAIR sequence on all patients. We used it to look for and grade endolymphatic hydrops in the utricle, the saccule and the cochlear canal using the Kahn method. Results: We found endolymphatic hydrops in all of the 30 patients who fulfilled the diagnostic criteria for Ménière's disease. We had no false positives and only one false negative with a patient presenting with bilateral disease clinically but having endolymphatic hydrops only on one side. Thus, our correspondence rate between clinical and imaging findings was 97%. Conclusions: It is possible to diagnose endolymphatic hydrops with the late-enhanced 3D FLAIR sequence using a 1.5 T MRI machine. Since Ménière's disease diagnosis is sometimes tricky, imaging endolymphatic hydrops can aid in the diagnosis when the clinical picture is incomplete. It also helps guide invasive treatment plans. Feasibility at 1.5 T ensures broader access to the late-enhanced 3D FLAIR sequence. Beyond the scope of Ménière's disease, this sequence offers the possibility to better understand pressure-related inner ear diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
14. CAUSAS DE VÉRTIGO PERIFÉRICO EN LA INFANCIA.
- Author
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COSCARÓN-BLANCO, Enrique, SANTOS-GORJÓN, Pablo, PÉREZ-LIEDO, María-Cruz, DE PRADO-SAN JOSÉ, Mar, MARTÍN-BAILÓN, María, BAUER, Michael, SUÁREZ-ORTEGA, María-Soledad, and GONZÁLEZ-SÁNCHEZ, Miriam
- Subjects
- *
BENIGN paroxysmal positional vertigo , *MENIERE'S disease , *VERTIGO , *OTITIS media , *NEUROPLASTICITY , *NEURITIS , *DESELECTION of library materials - Abstract
Introduction and objective: Within acute and episodic childhood vertigos, those secondary to trauma, otitis media, neuritis/labyrinthitis, perilymphatic fistula, Ménière's disease, vestibular paroxysmia, benign paroxysmal positional vertigo and bilateral vestibulopathy account for around 10% of all cases of infant vestibular disorders. Diagnosis must be early accomplished based on the defining criteria, although in children there are other accessory criteria that should be considered (behavioral changes, digestive, etc...). The treatment should achieve prompt symptomatic resolution of the crises, prevention or reduction of recurrences, minimization and palliation of sequelae and maximum normalization of daily life and activities. Objective: To carry out a brief and practical review on the symptoms, the diagnostic criteria and the treatment of infantile vertigo in the previously mentioned topics. Method: Narrative review using PubMed, Fisterra, ClinicalKey and Google Scholar. Results: Citations were obtained, of which non-significant ones were discarded due to their general nature, age, non-relevance according to the authors' criteria, or non-availability in English or Spanish. A total of 60 articles were considered for this review. Discussion: Narrative review on the topics described. Conclusions: The diagnostic criteria and treatment for the topics proposed in this chapter are defined for adults; however, in children, we must consider accessory criteria for a prompt diagnosis. The treatment is conditioned by age and is based on several pillars (pharmacological, lifestyle, rehabilitation and psychological). The prognosis, in general, is better than that of adults due to childhood neural plasticity. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
15. Vestibular Precision: Physiology & Pathophysiology
- Author
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Richard Lewis, Associate Professor, Otolaryngology and Neurology; Director, Jenks Vestibular Laboratory, Massachusetts Eye and Ear Infirmary.
- Published
- 2023
16. Subjective Visual Vertical and Vestibular Evoked Myogenic Potential in Meniere's disease
- Author
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Maristela Mian Ferreira, Karen de Carvalho Lopes, Thaís Alvares de Abreu e Silva Grigol, Maurício Malavasi Ganança, and Heloisa Helena Caovilla
- Subjects
Labyrinth diseases ,Meniere's disease ,Saccule and utricle ,Vestibular function tests ,Vestibular evoked myogenic potentials ,Otorhinolaryngology ,RF1-547 - Abstract
Objective: To evaluate otolith function by comparing the findings of the Subjective Visual Vertical, the cervical Vestibular Evoked Myogenic Potential and the ocular Vestibular Evoked Myogenic Potential tests in patients in the inter-crisis period of unilateral definite Meniere's disease. Methods: The sample consisted of an experimental group (n = 22; 10 men and 12 women, mean age 47.32 ± 12.82 years) with definite unilateral Meniere's disease and a control group (n = 14; 5 men and 9 women, with a mean age of 41.64 ± 13.45 years). They all underwent vestibular evaluation by means of Subjective Visual Vertical with the bucket method and, cervical and ocular Vestibular Evoked Myogenic Potential tests. The data were collected and subjected to statistical analysis. Results: The results of the comparison of the Subjective Visual Vertical, the cervical Vestibular Evoked Myogenic Potential, the ocular Vestibular Evoked Myogenic Potential and, the association of cervical Vestibular Evoked Myogenic Potential with the ocular Vestibular Evoked Myogenic Potential showed no significant difference, indicating concordance among the tests. Conclusion: The identified abnormalities and the concordance between the combined proportion of the Subjective Visual Vertical, the cervical Vestibular Evoked Myogenic Potential and the ocular Vestibular Evoked Myogenic Potential findings indicate that the association of these three tests contributes to the identification of sustained and transient otolith dysfunction in the inter-crisis of unilateral definite Meniere’s disease. Level of evidence: 2.
- Published
- 2023
- Full Text
- View/download PDF
17. Cerebral Outflow Discrepancies in Recurrent Benign Paroxysmal Positional Vertigo: Focus on Ultrasonographic Examination.
- Author
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Ciorba, Andrea, Tessari, Mirko, Natale, Erennio, Buzzi, Fabio, Baldazzi, Giulia, Cosacco, Alessio, Migliorelli, Andrea, Corazzi, Virginia, Bianchini, Chiara, Stomeo, Francesco, Pelucchi, Stefano, and Zamboni, Paolo
- Subjects
- *
BENIGN paroxysmal positional vertigo , *VENOUS insufficiency , *INNER ear - Abstract
This prospective pilot study aimed to evaluate whether cerebral inflow and outflow abnormalities assessed by ultrasonographic examination could be associated with recurrent benign paroxysmal positional vertigo (BPPV). Twenty-four patients with recurrent BPPV, affected by at least two episodes, and diagnosed according to American Academy of Otolaryngology–Head and Neck Surgery (AAO–HNS) criteria, evaluated at our University Hospital, between 1 February 2020 and 30 November 2021, have been included. At the ultrasonographic examination, 22 of 24 patients (92%) reported one or more alterations of the extracranial venous circulation, among those considered for the diagnosis of chronic cerebrospinal venous insufficiency (CCSVI), although none of the studied patients were found to have alterations in the arterial circulation. The present study confirms the presence of alterations of the extracranial venous circulation in recurrent BPPV; these anomalies (such as stenosis, blockages or regurgitation of flow, or abnormal valves, as per the CCSVI) could cause a disruption in the venous inner ear drainage, hampering the inner ear microcirculation and then possibly causing recurrent otolith detachment. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
18. Potencial evocado miogênico vestibular e eletrococleografia em pacientes com vertigem posicional paroxística benigna.
- Author
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Rossetto, Ana Paula, Chaves Aita, Aline Domingues, Sbicigo Aita, Fabiano, Gazzola Zen, Paulo Ricardo, and Sleifer, Pricila
- Subjects
EVOKED response audiometry ,AUDITORY evoked response ,EVOKED potentials (Electrophysiology) ,CROSS-sectional method ,VESTIBULAR apparatus diseases ,BENIGN paroxysmal positional vertigo ,DISEASE complications - Abstract
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- Published
- 2023
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19. INNER EAR, NOSE AND PHARYNX - SIGNS AND SYMPTOMS OF CORONAVIRUS DISEASE 2019 INFECTION.
- Author
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PISARIĆ, Milica and KOMAZEC, Slobodanka LEMAJIĆ
- Subjects
- *
SMELL disorders , *CORONAVIRUS diseases , *COVID-19 , *SYMPTOMS , *INNER ear , *HEARING disorders , *SENSORINEURAL hearing loss - Abstract
Introduction. The most common clinical symptoms of coronavirus disease 2019 include cough, high body temperature, malaise, weakness, headache, and diarrhea. When the pandemic slowed down, more and more patients reported symptoms atypical for the infection, such as hearing loss, tinnitus, and vertigo. The aim of this study was to assess current knowledge and data on the existence and prevalence of otorhinolaryngology sings and symptoms of coronavirus disease 2019. Material and Methods. The literature was reviewed from May to December 2022 and included articles published in 2020 or later. The main criterion was confirmed severe acute respiratory syndrome coronavirus 2 infection by means of the polymerase chain reaction test. Results. Sensorineural hearing loss presents as acute, chronic and subclinical. Tinnitus is associated with direct viral invasion and social factors. Vertigo is also associated with direct viral invasion and prolonged bed rest. Olfactory and gustatory disorders are known symptoms of viral infections. Olfactory dysfunction occurs as a consequence of the existence of angiotensin-converting enzyme 2 receptors in the nasal mucosa, which is the primary site for viral binding, and which explains the absence of nasal congestion. It has been shown that the pediatric population presents with different clinical symptoms of the infection. In children, rhinorrhea and pharyngitis are the most common symptoms, while in adults they are generally absent. Conclusion. The available literature data showed that otorhinolaryngology symptomatology of coronavirus disease 2019 is present, but the data are still very limited. The literature showed vast discrepancies in the prevalence and risk factors associated with coronavirus disease 2019. It is imperative that more research is done on the topic now that the pandemic is subsiding, and more attention should be paid to non-life-threatening symptoms. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
20. Endolymphatic sac tumor in an 8-month-old cat
- Author
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Matteo Baccolini, Marco Rosati, Federica Tirrito, Francesca Cozzi, and Rocco Lombardo
- Subjects
cat ,endolymphatic sac ,inner ear ,labyrinth diseases ,neoplasia ,Zoology ,QL1-991 - Abstract
Background: The endolymphatic sac is an organ devoid of sensory receptors. It is connected with the endolymphatic compartment and contains endolymph. Endolymphatic sac tumor is a rare neoplasm involving the middle and inner ear described in humans and dogs, does not show cellular characteristics of malignancy, but can be locally invasive and involve destruction of the temporal bone and adjacent structures. Case Description: An eight months old female cat was referred because of sudden onset of vestibular signs starting three days prior to referral. On clinical examination the patient showed depression, right head-tilt, left sided facial paralysis, horizontal nystagmus with fast phase to the left. The magnetic resonance images showed a voluminous extra axial lesion, with irregular morphology and well-defined margins, with intracranial extension in the region of the pons, rostral medulla oblongata, cerebellar vermis, floccule and left cerebellar hemisphere. Due to the progressive clinical deterioration, the cat was euthanized two weeks later. A necropsy was then performed and histological samples taken. The necropsy revealed the presence of a voluminous dark red irregular mass extending from the tympanic bulla to the posterior cranial fossa following the left glossopharyngeal nerve. The histopathologic exam of the extra-axial lesion featured a non-encapsulated, moderately cellular, rather loose, proliferation of cuboidal to columnar epithelium breaching through chunks of an otherwise normal appearing dura mater and invading some cranial nerves. Sections of the cerebellum and brainstem revealed moderate, focal, impingement of the parenchyma with very mild extension of the proliferating cells into the ventral left side of the medulla oblongata. Based on these histological characteristics, the lesion was defined as endolymphatic sac tumor, a rare neoplasm described in human beings and with two reports in dogs. Conclusion: To our knowledge, this is the first report describing an endolymphatic sac tumor in a cat.
- Published
- 2022
- Full Text
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21. A Study of SENS 401 in Healthy Subjects
- Author
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Sensorion and Robert Adams, Prinicipal Investigator, MBBS
- Published
- 2019
22. Decompression sickness of the inner ear and relationship with a patent oval foramen: a study of 61 cases.
- Author
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Quatre R, Delafosse B, Schmerber S, and Soriano E
- Subjects
- Humans, Retrospective Studies, Male, Female, Adult, Middle Aged, Aged, Hyperbaric Oxygenation methods, Young Adult, Labyrinth Diseases, Ear, Inner, Adolescent, Decompression Sickness therapy, Foramen Ovale, Patent complications
- Abstract
Objective: To discuss the link between inner ear decompression sickness and patent foramen ovale., Materials and Methods: Monocentric and retrospective study on decompression sickness of the inner ear requiring hyperbaric chamber treatment, from 2014 to 2021., Results: Sixty-one patients of inner ear decompression sickness were included in this study. Twenty-four patients had vestibular injuries, 28 cochlear injuries and 9 cochleo-vestibular injuries. Compression chamber treatment was given, using an oxygen-helium mixture with oxygen partial pressure (PIO2) limited to 2.8 atmosphere absolute (ATA). All vestibular accidents completely recovered without clinical sequelae. For cochlear accident only 10 out of 37 patients (27%) recovered completely. A right-left shunt (patent foramen oval or intra-pulmonary shunt) was found in 31.1% of patients with inner ear decompression sickness (p > 0.05)., Conclusion: The presence of patent foramen oval in patients with inner ear decompression was not statistically significant in our study. Understanding of the pathophysiology of decompression illness and the physiology and anatomy of the labyrinth would suggest a mechanism of supersaturation with degassing in intra-labyrinthine liquids., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
- Published
- 2024
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23. Cerebral Outflow Discrepancies in Recurrent Benign Paroxysmal Positional Vertigo: Focus on Ultrasonographic Examination
- Author
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Andrea Ciorba, Mirko Tessari, Erennio Natale, Fabio Buzzi, Giulia Baldazzi, Alessio Cosacco, Andrea Migliorelli, Virginia Corazzi, Chiara Bianchini, Francesco Stomeo, Stefano Pelucchi, and Paolo Zamboni
- Subjects
benign paroxysmal positional vertigo ,labyrinth diseases ,chronic cerebrospinal venous insufficiency ,jugular veins ,ultrasonography doppler ,Medicine (General) ,R5-920 - Abstract
This prospective pilot study aimed to evaluate whether cerebral inflow and outflow abnormalities assessed by ultrasonographic examination could be associated with recurrent benign paroxysmal positional vertigo (BPPV). Twenty-four patients with recurrent BPPV, affected by at least two episodes, and diagnosed according to American Academy of Otolaryngology–Head and Neck Surgery (AAO–HNS) criteria, evaluated at our University Hospital, between 1 February 2020 and 30 November 2021, have been included. At the ultrasonographic examination, 22 of 24 patients (92%) reported one or more alterations of the extracranial venous circulation, among those considered for the diagnosis of chronic cerebrospinal venous insufficiency (CCSVI), although none of the studied patients were found to have alterations in the arterial circulation. The present study confirms the presence of alterations of the extracranial venous circulation in recurrent BPPV; these anomalies (such as stenosis, blockages or regurgitation of flow, or abnormal valves, as per the CCSVI) could cause a disruption in the venous inner ear drainage, hampering the inner ear microcirculation and then possibly causing recurrent otolith detachment.
- Published
- 2023
- Full Text
- View/download PDF
24. Correlation of clinical parameters with endolymphatic hydrops on MRI in Meniere's disease.
- Author
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Seung Cheol Han, Young Seok Kim, Yehree Kim, Sang-Yeon Lee, Jae-Jin Song, Byung Yoon Choi, Ji-Soo Kim, Yun Jung Bae, and Ja-Won Koo
- Subjects
MENIERE'S disease ,HYDROPS fetalis ,MAGNETIC resonance imaging ,INNER ear ,EDEMA ,VESTIBULAR function tests - Abstract
A clinical diagnosis of Ménière’s disease (MD) is made based on medical history and audiometry findings. The 1995 American Academy of OtolaryngologyHead and Neck Surgery (AAO-HNS) guidelines requires histopathological confirmation of endolymphatic hydrops (EH) for a diagnosis of “certain” MD. Symptoms such as dizziness and ear fullness are important diagnostic features; however, the descriptions provided by patients are frequently vague and nonspecific. A recently developed magnetic resonance imaging (MRI) protocol to document EH is, therefore, useful for the evaluation of inner ear status in patients with MD. In this study, patients with MD were assessed using MRI and the HYDROPS (HYbriD of Reversed image Of Positive endolymph signal and native image of positive perilymph Signal) protocol to investigate the eectiveness of MRI for visualization of the endolymphatic space in the diagnosis of MD by correlating clinical laboratory parameters with the grade of EH. Of the 123 patients with MD recruited in this study, 80 had definite MD, 11 had probable MD, and 32 had possible MD based on the 1995 AAOHNS guidelines. The EH grade based on HYDROPS MRI was determined independently by two otorhinolaryngologists and compared with several clinical parameters, including the diagnostic scale of MD (1995 AAO-HNS guidelines), pure tone average (PTA), low tone average (LTA), canal paresis (CP) on the caloric test, and disease duration. Cochlear hydrops and vestibular hydrops were detected in 58 and 80% of 80 definite MD ears, in 33 and 58% of 12 probable MD ears, and in 5 and 27% of 37 possible MD ears, respectively. The proportion of higher hydrops grades increased significantly with grade according to the MD diagnostic scale (p < 0.0001). Both PTA and LTA were significantly higher in patients with hydrops grade 2 than hydrops grade 0 in both the cochlea and the vestibule. CP was significantly higher in patients with grade 2 than grade 0 vestibular hydrops. Disease duration was not associated with hydrops grade. Radiological evaluation of MD using the HYDROPS protocol is useful for evaluation of the extent and severity of EH in the diagnosis of MD based on its pathophysiological mechanism. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
25. Endolymphatic sac tumor in an 8-month-old cat.
- Author
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Baccolini, Matteo, Rosati, Marco, Tirrito, Federica, Cozzi, Francesca, and Lombardo, Rocco
- Subjects
- *
MIDDLE ear , *POSTERIOR cranial fossa , *MEDULLA oblongata , *INNER ear , *SENSORY receptors , *DURA mater , *TEMPORAL bone - Abstract
Background: The endolymphatic sac is an organ devoid of sensory receptors. It is connected with the endolymphatic compartment and contains endolymph. Endolymphatic sac tumor (ELST) is a rare neoplasm involving the middle and inner ear described in humans and dogs that does not show cellular characteristics of malignancy, but can be locally invasive and involve destruction of the temporal bone and adjacent structures. Case Description: An 8-month-old female cat was referred because of sudden onset of vestibular signs starting 3 days prior to referral. On clinical examination, the patient showed depression, right head tilt, left-sided facial paralysis, and horizontal nystagmus with fast phase to the left. The magnetic resonance images showed a voluminous extra-axial lesion, with irregular morphology and well-defined margins, with intracranial extension in the region of the pons, rostral medulla oblongata, cerebellar vermis, floccule, and left cerebellar hemisphere. Due to progressive clinical deterioration, the cat was euthanized 2 weeks later. A necropsy was then performed and histological samples were taken. The necropsy revealed the presence of a voluminous dark red irregular mass extending from the tympanic bulla to the posterior cranial fossa following the left glossopharyngeal nerve. The histopathological exam of the extra-axial lesion featured a nonencapsulated, moderately cellular, rather loose, proliferation of cuboidal to columnar epithelium breaching through chunks of an otherwise normal appearing dura mater and invading some cranial nerves. Sections of the cerebellum and brainstem revealed moderate, focal, impingement of the parenchyma with a very mild extension of the proliferating cells into the ventral left side of the medulla oblongata. Based on these histological characteristics, the lesion was defined as ELST, a rare neoplasm described in human beings and with two reports in dogs. Conclusion: To our knowledge, this is the first report describing an ELST in a cat. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
26. Superior Semicircular Canal Dehiscence Symptoms Unmasked by Ossicular Chain Reconstruction.
- Author
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Moshtaghi, Omid, Mahboubi, Hossein, Djalilian, Hamid R, and Lin, Harrison W
- Subjects
Semicircular Canals ,Humans ,Labyrinth Diseases ,Otosclerosis ,Stapes Surgery ,Adult ,Male ,SSCD ,ossicular chain reconstruction ,superior semicircular canal dehiscence ,Otorhinolaryngology ,Clinical Sciences - Published
- 2017
27. Unilateral Peripheral Vestibular Dysfunction: Reeducation and Spatial Orientation.
- Author
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Aragon Institute of Health Sciences and Pilar Dominguez-Olivan, Ph D. Physical Therapist.
- Published
- 2018
28. A Clinical Trial of Anakinra for Steroid-Resistant Autoimmune Inner Ear Disease
- Author
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National Institute on Deafness and Other Communication Disorders (NIDCD) and Andrea Vambutas, Professor of Otolaryngology & Molecular Medicine
- Published
- 2017
29. Labyrinthine Fistula in Cholesteatoma Patients: Outcomes of Partial Labyrinthectomy With "Underwater Technique" to Preserve Hearing.
- Author
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Pace, Annalisa, Milani, Alessandro, Messineo, Daniela, Rossetti, Valeria, Cocuzza, Salvatore, Maniaci, Antonino, Vicini, Claudio, Iannella, Giannicola, and Magliulo, Giuseppe
- Subjects
CHOLESTEATOMA ,UNDERWATER drilling ,FISTULA ,SEMICIRCULAR canals ,PHYSIOLOGIC salines - Abstract
Labyrinthine fistula (LF) is one of the most important complications of cholesteatoma and is defined as an abnormal communication between the inner and the middle ear. This study aims to describe our experience with the partial labyrinthectomy evaluating the post-operative hearing results. Twenty-one patients who presented labyrinthine fistula in the semicircular canals were included in the present study. Hearing impairment was present in 48% of patients (10/21). A pre-operative assessment using the Gardner–Robertson hearing classification showed the following: 52%, Class I; and 48%, Class II. A post-surgical Gardner–Robertson hearing classification evidenced the following: 43%, Class I; and 57%, Class II. The presence of LF is usually considered a negative prognostic factor for hearing preservation. The key point of partial labyrinthectomy surgery is the preservation of structures, keeping them wet with Ringer's solution throughout the procedures, and not performing suction that is close to the opened LF. The bony labyrinth is drilled underwater without suction, removing the entire cholesteatoma matrix and quickly plugging the site before and after the LF. This faster plugging of the labyrinth makes it possible to preserve the peri-lymph and the endo-lymph fluid and the hearing function. This study showed that a partial labyrinthectomy is useful for maintaining serviceable hearing in patients with LF. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
30. Pneumolabyrinth: A Rare Cause of Vertigo after Minor Ear Trauma
- Author
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Andreia Bilé, Mariana Eiras Dias, and Rita Belo Morais
- Subjects
Fistula ,Labyrinth Diseases ,Vertigo ,Medicine ,Medicine (General) ,R5-920 - Abstract
N/a.
- Published
- 2022
- Full Text
- View/download PDF
31. Labyrinthine Fistula in Cholesteatoma Patients: Outcomes of Partial Labyrinthectomy With 'Underwater Technique' to Preserve Hearing
- Author
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Annalisa Pace, Alessandro Milani, Daniela Messineo, Valeria Rossetti, Salvatore Cocuzza, Antonino Maniaci, Claudio Vicini, Giannicola Iannella, and Giuseppe Magliulo
- Subjects
labyrinth diseases ,fistula ,cholesteatoma ,otologic surgical procedure ,underwater technique ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Labyrinthine fistula (LF) is one of the most important complications of cholesteatoma and is defined as an abnormal communication between the inner and the middle ear. This study aims to describe our experience with the partial labyrinthectomy evaluating the post-operative hearing results. Twenty-one patients who presented labyrinthine fistula in the semicircular canals were included in the present study. Hearing impairment was present in 48% of patients (10/21). A pre-operative assessment using the Gardner–Robertson hearing classification showed the following: 52%, Class I; and 48%, Class II. A post-surgical Gardner–Robertson hearing classification evidenced the following: 43%, Class I; and 57%, Class II. The presence of LF is usually considered a negative prognostic factor for hearing preservation. The key point of partial labyrinthectomy surgery is the preservation of structures, keeping them wet with Ringer's solution throughout the procedures, and not performing suction that is close to the opened LF. The bony labyrinth is drilled underwater without suction, removing the entire cholesteatoma matrix and quickly plugging the site before and after the LF. This faster plugging of the labyrinth makes it possible to preserve the peri-lymph and the endo-lymph fluid and the hearing function. This study showed that a partial labyrinthectomy is useful for maintaining serviceable hearing in patients with LF.
- Published
- 2022
- Full Text
- View/download PDF
32. A Basis for Standardizing Superior Semicircular Canal Dehiscence Management.
- Author
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Cozart, Ashley C., Kennedy III, John T., and Seidman, Michael D.
- Subjects
- *
EVALUATION of medical care , *CONFIDENCE intervals , *DEAFNESS , *SUPERIOR semicircular canal dehiscence syndrome , *MAGNETIC resonance imaging , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *PHYSICIANS , *COMPUTED tomography , *EMAIL , *SYMPTOMS - Abstract
Objectives: (1) To determine how otologic/neurotologic surgeons counsel patients with superior semicircular canal dehiscence (SSCD). (2) To understand the plethora of presenting symptoms associated with SSCD and appropriate management. (3) To suggest appropriate management; oftentimes avoiding surgery. Methods: This was a survey study of both community and academic physicians. A 23-question survey was distributed to all members of the American Neurotological (ANS) and American Otologic Societies (AOS) via email in the Fall of 2018. A total of 54 responses were received from a possible pool of 279 for a response rate of 19.4%. Inferences were made about the population through sample proportions and confidence intervals. Results: All respondents use computed tomography (CT) in diagnosing SSCD and 11.1% use CT exclusively. Cervical vestibular evoked myogenic potential (VEMP; 77.8%) are used more often than ocular VEMPs (38.9%). Magnetic resonance imaging (7.4%) is used infrequently; 96.3% of surgeons surveyed have seen patients with SSCD on imaging that are asymptomatic. Following surgical treatment, respondents reported balance issues and mild-to-moderate high-frequency sensorineural hearing loss (88.4%); 32.6% reported that the majority (>50%) of their patients needed further intervention after surgery, typically aggressive vestibular rehabilitation. Conclusions: There is a discrepancy in the systematic approach to SSCD between both the surgeons and the published literature. Patients with SSCD on ultra-high-resolution CT may have myriad symptoms while others are asymptomatic, and surgery may lead to additional complications. We will present a methodical recommendation to assist in the management of patients with SSCD depending upon their symptoms. This may improve patient selection, counseling, and outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
33. Paraneoplastic Syndrome
- Author
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Greene, Jacqueline J, Keefe, Michael W, Harris, Jeffrey P, and Matsuoka, Akihiro J
- Subjects
Autoimmune Disease ,Clinical Research ,Biotechnology ,Rare Diseases ,Hematology ,Neurosciences ,Ear ,Adult ,Autoimmune Diseases ,Female ,Hearing Loss ,Sudden ,Hodgkin Disease ,Humans ,Kidney Neoplasms ,Labyrinth Diseases ,Male ,Middle Aged ,Neoplasm Recurrence ,Local ,Paraneoplastic Syndromes ,Thymoma ,Autoimmune inner ear disease ,Paraneoplastic cochleovestibulopathy ,Paraneoplastic syndrome ,Zoology ,Clinical Sciences ,Public Health and Health Services ,Otorhinolaryngology - Abstract
Rare and diagnostically challenging, paraneoplastic syndromes can appear months to years before detection of their underlying neoplasms and are associated with rapidly progressive neurologic deficits, including cochleovestibulopathy and death. Less than 20 cases of paraneoplastic cochleovestibulopathy have been reported in the online database PubMed. We present three recent cases: one patient with a history of B-cell follicular lymphoma who developed dermatomyositis and hearing loss before detection of lymphoma recurrence in his anterior chest wall, a second patient with sudden asymmetric hearing loss, found to have a 12-cm renal mass before death, and a third with fluctuating bilateral hearing loss who was ultimately found to have a thymoma. Although characterized as type VI (non-immune rapidly progressive sensorineural hearing loss) within the Harris autoimmune inner ear disease classification system, the mechanism of paraneoplastic cochleovestibulopathy is not well understood. Although specific anti-neuronal antibodies such as anti-Hu may be associated with other paraneoplastic neurologic disorders, these antibodies have limited diagnostic utility with paraneoplastic cochleovestibulopathy. Steroids have limited efficacy with regard to hearing recovery, whereas intravenous immunoglobulin has been shown to be of benefit. These recent cases demonstrate how auditory and vestibular deficits may be indicative of a rare but potentially life-threatening occult neoplasm where timely diagnosis is critical. We believe that understanding paraneoplastic cochleovestibulopathy is of interest across a broad range of clinical practices.
- Published
- 2015
34. A Single Dose PK Study of SENS-218 in Healthy Volunteers
- Author
-
Sensorion SA and Girish Sharma, MBBS
- Published
- 2016
35. The Effects of Gevokizumab in Corticosteroid-resistant Subjects With Autoimmune Inner Ear Disease
- Author
-
Feinstein Institute for Medical Research and National Institute on Deafness and Other Communication Disorders (NIDCD)
- Published
- 2016
36. Labyrinthine Fistulae in Squamosal Type of Chronic Otitis Media: Therapeutic Outcome
- Author
-
Priyanka Misale, Anjali Lepcha, Ramanathan Chandrasekharan, and Manusrut Manusrut
- Subjects
Cholesteatoma ,Hearing Loss ,Labyrinth diseases ,Middle Ear ,vertigo ,Otorhinolaryngology ,RF1-547 - Abstract
Introduction: Labyrinthine fistulae (LF) are the common complications of chronic otitis media (COM) of squamosal variety. The final therapeutic outcome of this condition is to preserve the cochlear and vestibular functions. Herein, we present the data of the cases managed at our institute with respect to their presenting complaints, adopted therapeutic approaches and outcomes. Materials and Methods: A retrospective chart review was conducted on all cases with COM squamosal type in adult patients. A total of 275 patients were reviewed, out of whom 30 cases had LF. The results were mainly studied with respect to the postoperative improvement of hearing and vertigo. Results: The incidence rate of LF in the present study was obtained at 10.9%. Only 50% of the cases had the symptoms of vertigo. Furthermore, positive fistula test was elicited in 3.3% of the cases. All cases undergoing preoperative imaging were diagnosed successfully. In addition, 42.85% of the cases had profound hearing loss preoperatively, which sustained after the operation. However, 47.61% of the cases showed an improvement of at least ≥ 10 dB in the air-bone gap. Out of the 15 LF cases with vertigo as the main complaint, only 11 cases referred for follow-up. In this regard, 63.63% of the cases had no postoperative vertigo symptoms. Conclusion: Patients with LF may not have complaints of vertigo and a positive fistula sign upon admission. Pre-operative imaging facilitates the diagnosis of this condition. The removal of the matrix under constant irrigation, followed by repair with bone wax and/or autologous tissue, is sufficient to preserve the cochlear and vestibular symptoms postoperatively.
- Published
- 2019
- Full Text
- View/download PDF
37. Effectiveness of Osteopathic Manipulative Treatment (OMT) and Vestibular Rehabilitation Therapy (VRT) in Individuals With Vertigo
- Published
- 2015
38. [Research progress in targeted delivery of inner ear using nanocarriers].
- Author
-
Chen Y and Zhang H
- Subjects
- Humans, Quality of Life, Ear, Inner, Labyrinth Diseases, Meniere Disease drug therapy, Hearing Loss, Sensorineural
- Abstract
Various inner ear diseases such as sensorineural deafness and Meniere's disease bring about problems such as speech communication disorders and decreased work efficiency, which seriously affect the life quality of patients. Due to the special anatomical structure and blood-labyrinth barrier in the inner ear, the current drug administration methods are often unable to achieve satisfactory results. Nanocarriers are the forefront and hot spot of nanotechnology research. In recent years, a lot of research progress has been made in the field of targeted delivery of the inner ear, which is expected to be eventually applied to the treatment of clinical diseases of the inner ear. This review focuses on the advantages, main research achievements and limitations of various nanocarriers in the targeted delivery of the inner ear, hoping to provide new ideas for related research., Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose., (Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.)
- Published
- 2024
- Full Text
- View/download PDF
39. Impact of Superior Canal Dehiscence Syndrome on Health Utility Values: A Prospective Case-Control Study
- Author
-
Ibrahim Ocak, Vedat Topsakal, Paul Van de Heyning, Gilles Van Haesendonck, Cathérine Jorissen, Raymond van de Berg, Olivier M. Vanderveken, and Vincent Van Rompaey
- Subjects
vestibular system ,autophony ,health-realeted quality of life ,labyrinth diseases ,vertigo ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Introduction: Superior canal dehiscence syndrome (SCDS) is a condition characterized by a defect in the bone overlying the superior semicircular canal, creating a third mobile window into the inner ear. Patients can experience disabling symptoms and opt for surgical management. Limited data are available on the impact of SCDS on health-related quality of life (HRQoL) and disease-specific HRQoL more specifically.Objective: To perform a prospective analysis on generic HRQoL in SCDS patients compared to healthy age-matched controls.Methods: A prospective study was performed on patients diagnosed with SCDS and who did not undergo reconstructive surgery yet. Patients were recruited between November 2017 and January 2020 and asked to complete the Health Utility Index (HUI) Mark 2 (HUI2)/Mark 3 (HUI3) questionnaire. For the control group, age-matched participants without otovestibular pathology or other chronic pathology were recruited. The multi-attribute utility function (MAUF) score was calculated for the HUI2 and HUI3. Results of both groups were compared using the Mann-Whitney U test.Results: A total of 20 patients completed the questionnaire. Age ranged from 37 to 79 years with a mean age of 56 years (45% males and 55% females). The control group consisted of 20 participants with a mean age of 56.4 years and ranged from 37 to 82 years (35% males and 65% females). For the case group, median HUI2 MAUF score was 0.75 and median HUI3 MAUF score was 0.65. For the control group, the median scores were 0.88 and 0.86 respectively. There was a statistically significant difference for both HUI2 (p = 0.024) and HUI3 (p = 0.011). SCDS patients had a worse generic HRQoL than age-matched healthy controls. One patient with unilateral SCDS had a negative HUI3 MAUF score (−0.07), indicating a health-state worse than death.Conclusion: SCDS patients have significantly lower health utility values than an age-matched control group. This confirms the negative impact of SCDS on generic HRQoL, even when using an instrument that is not designed to be disease-specific but to assess health state in general. These data can be useful to compare impact on HRQoL among diseases.
- Published
- 2020
- Full Text
- View/download PDF
40. Association between diabetes and vestibular dysfunction: an integrative review
- Author
-
Roberta Carneiro de Toledo, Cibelle Kayenne Martins Roberto Formiga, and Flávio Monteiro Ayres
- Subjects
Dizziness ,Vertigo ,Diabetes Mellitus ,Labyrinth Diseases ,Philology. Linguistics ,P1-1091 ,Otorhinolaryngology ,RF1-547 - Abstract
ABSTRACT Purpose: to identify, in the literature, the factors associated with the development of vestibular dysfunctions in individuals with type 2 diabetes mellitus (DM2). Methods: an integrative review of the literature, whose survey was conducted in the databases ISI, SciELO, LILACS and PubMed, using the following descriptors: “type 2 diabetes mellitus”, “vertigo”, “dizziness”, and “vestibular diseases". Articles published in the last 10 years that answered the research question (“What factors are associated with the development of vestibular disorders in individuals with DM2?”) were included in the study. Results: the search returned 426 articles, 10 of which met the eligibility criteria. Most of the participants of the selected studies who had vestibular dysfunctions were women over 40 years old and had more than one comorbidity related to DM2, the main one being the systemic arterial hypertension (SAH). According to the literature, the physiology of the inner ear allows small glucose alterations to influence its normal functioning, which makes diabetic individuals more susceptible to developing vestibular dysfunctions. Conclusion: according to this study, DM2 can trigger or contribute to the manifestation of vestibular dysfunction, whose main associated factors are advanced age, female gender, and various comorbidities, as dyslipidemia, SAH and metabolic syndrome.
- Published
- 2020
- Full Text
- View/download PDF
41. Impact of Superior Canal Dehiscence Syndrome on Health Utility Values: A Prospective Case-Control Study.
- Author
-
Ocak, Ibrahim, Topsakal, Vedat, Van de Heyning, Paul, Van Haesendonck, Gilles, Jorissen, Cathérine, van de Berg, Raymond, Vanderveken, Olivier M., and Van Rompaey, Vincent
- Subjects
LONGITUDINAL method ,CASE-control method ,MANN Whitney U Test ,SEMICIRCULAR canals ,INNER ear - Abstract
Introduction: Superior canal dehiscence syndrome (SCDS) is a condition characterized by a defect in the bone overlying the superior semicircular canal, creating a third mobile window into the inner ear. Patients can experience disabling symptoms and opt for surgical management. Limited data are available on the impact of SCDS on health-related quality of life (HRQoL) and disease-specific HRQoL more specifically. Objective: To perform a prospective analysis on generic HRQoL in SCDS patients compared to healthy age-matched controls. Methods: A prospective study was performed on patients diagnosed with SCDS and who did not undergo reconstructive surgery yet. Patients were recruited between November 2017 and January 2020 and asked to complete the Health Utility Index (HUI) Mark 2 (HUI2)/Mark 3 (HUI3) questionnaire. For the control group, age-matched participants without otovestibular pathology or other chronic pathology were recruited. The multi-attribute utility function (MAUF) score was calculated for the HUI2 and HUI3. Results of both groups were compared using the Mann-Whitney U test. Results: A total of 20 patients completed the questionnaire. Age ranged from 37 to 79 years with a mean age of 56 years (45% males and 55% females). The control group consisted of 20 participants with a mean age of 56.4 years and ranged from 37 to 82 years (35% males and 65% females). For the case group, median HUI2 MAUF score was 0.75 and median HUI3 MAUF score was 0.65. For the control group, the median scores were 0.88 and 0.86 respectively. There was a statistically significant difference for both HUI2 (p = 0.024) and HUI3 (p = 0.011). SCDS patients had a worse generic HRQoL than age-matched healthy controls. One patient with unilateral SCDS had a negative HUI3 MAUF score (−0.07), indicating a health-state worse than death. Conclusion: SCDS patients have significantly lower health utility values than an age-matched control group. This confirms the negative impact of SCDS on generic HRQoL, even when using an instrument that is not designed to be disease-specific but to assess health state in general. These data can be useful to compare impact on HRQoL among diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
42. Using betahistine in the treatment of patients with Menière's disease: a meta-analysis with the current randomized-controlled evidence.
- Author
-
Devantier, Louise, Hougaard, Dan, Händel, Mina Nicole, Liviu-Adelin Guldfred, Frank, Schmidt, Jesper Hvass, Djurhuus, Bjarki, and Callesen, Henriette Edemann
- Subjects
- *
DRUG therapy for vertigo , *INNER ear diseases , *MENIERE'S disease , *META-analysis , *PYRIDINE , *SYSTEMATIC reviews - Abstract
Background: Betahistine is used worldwide to treat patients with Menière's disease. However, despite it being used for decades, diverging opinions on the effect of betahistine on Menière's symptomatology still exist. Aims: The objective of this systematic review was to provide an overview and rate the certainty of the current evidence base regarding the use of betahistine to treat patients with Menière's disease. Materials and methods: A systematic literature search was conducted in October 2019. The search strategy was subdivided into searches for existing guidelines, systematic reviews and individual randomized controlled trials (RCT) investigating the usage of betahistine as compared to placebo, in patients with Ménière's disease. The primary outcome was the frequency of vertigo attack(s) and occurrence of serious adverse events. Results: We identified three relevant guidelines and three systematic reviews: however, neither included any relevant trials matching our inclusion criteria. An individual search for RCTs identified one trial. The results from this particular trial showed no difference in effects on symptoms following treatment with betahistine. Conclusions and Significance: There is a need for further well-conducted placebo RCTs. Currently, there is still a lack of substantial evidence supporting betahistine as a significant and adequate treatment for patients diagnosed with Menière's disease. Trial registration number: The protocol is registered in PROSPERO. Registration number: CRD42018110127 Accepted 11.10.2018 [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
43. Die Bárány-Klassifikation vestibulärer Erkrankungen: Grundlagen, klinische Anwendung und zukünftige Perspektiven.
- Author
-
Bisdorff, A.
- Abstract
Copyright of HNO is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2020
- Full Text
- View/download PDF
44. Intratympanic Injection of Autologous Blood for Traumatic Perilymphatic Fistulas
- Author
-
Garg, Rohit and Djalilian, Hamid Reza
- Subjects
Adult ,Blood Transfusion ,Autologous ,Craniocerebral Trauma ,Ear ,Female ,Fistula ,Hospitals ,University ,Humans ,Injections ,Intralesional ,Labyrinth Diseases ,Male ,Perilymph ,Retrospective Studies ,Treatment Outcome ,Tympanic Membrane ,Clinical Sciences ,Otorhinolaryngology - Published
- 2009
45. Evaluation of a Sensory Enrichment Multimodal Device (SEMD) on Physical Therapy Patients With Disequilibrium (SEMD)
- Author
-
Karen L Atkins, Study Director
- Published
- 2014
46. Matched Cohort Study of Radiographic Superior Semicircular Canal Dehiscence and Tegmen Dehiscence and Obstructive Sleep Apnea
- Author
-
Adam C, Kaufman, Shayna, Cooperman, Noor-E-Seher, Ali, and Jennifer C, Alyono
- Subjects
Adult ,Cohort Studies ,Sleep Apnea, Obstructive ,Semicircular Canal Dehiscence ,Otorhinolaryngology ,Labyrinth Diseases ,Humans ,Neurology (clinical) ,Semicircular Canals ,Sensory Systems ,Retrospective Studies - Abstract
To report the frequency of radiographic superior semicircular canal dehiscence (SSCD) and tegmen dehiscence in patients with and without obstructive sleep apnea (OSA).Retrospective matched cohort study.Tertiary care center.Adults with OSA and fine-cut computed tomographic scans including the temporal bone were matched to patients without OSA by age, sex, and type of computed tomography (protocol, scanner type, slice thickness). Ears with otologic surgery or temporal bone tumors were excluded.Prevalence of SSCD and tegmen dehiscence assessed by two independent reviewers.The average body mass index of the OSA patients was 29.2 kg/m 2 with an average apnea-hypopnea index of 36.8. The control group had an average body mass index of 26.2 kg/m 2 . Of the 352 temporal bones, 34 (9.7%) had SSCD in the OSA cohort versus 37 (10.5%) in the control group ( p0.05). Seven OSA patients (25.6% of those with SSCD) had bilateral SSCD versus 8 controls (27.6% of those with SSCD; p0.05). The majority (87.3%) of dehiscences involved the temporal lobe, with the remaining involving the superior petrosal sinus or both. Of the 352 OSA ears, 90 (25.6%) had a tegmen dehiscence versus 95 (27.0%) in the control group ( p0.05). Neither group had a laterality preference for SSCD or tegmen dehiscence.The prevalence of radiographic SSCD and tegmen dehiscences in OSA patients does not significantly differ from age- and sex-matched controls. This is in contrast to a previous case-control study finding patients with symptomatic SSCD to have higher rates of OSA. This may suggest that the effect size of OSA on SSCD prevalence may be limited despite OSA being a risk factor for elevated intracranial pressure.
- Published
- 2022
47. Assessment of Metabolic Markers and Osteoporosis in 250 Patients with Superior Semicircular Canal Dehiscence Treated With Middle Fossa Craniotomy
- Author
-
Daniel P. Kulinich, Ava Kjos, Roan Anderson, Mahlet Mekonnen, Ashley B. Zhang, Quinton Gopen, and Isaac Yang
- Subjects
Semicircular Canal Dehiscence ,Arthritis ,Labyrinth Diseases ,Semicircular Canals ,Humans ,Osteoporosis ,Calcium ,Female ,Surgery ,Neurology (clinical) ,Vitamin D ,Hearing Loss ,Craniotomy ,Retrospective Studies - Abstract
Superior semicircular canal dehiscence (SSCD) is caused by bony defects in the osseous shell of the arcuate eminence separating the labyrinth and the intracranial space. This pathologic third window causes hydroacoustic transmission resulting in debilitating symptoms. We examine the pathophysiologic association between metabolic markers, previous medical history, and SSCD symptoms before and after middle fossa craniotomy (MFC) treatment.This study was conducted between March 2011 and September 2020 with patients with SSCD who underwent MFC. We used a Fisher test to compare variables, including bilateral SSCD, second surgery, ear anomaly, osteoporosis, arthritis, vitamin D, and preoperative/postoperative symptoms, and others. Point-biserial correlation analysis was performed to test correlations between continuous variables and categorical variables.A total of 250 patients with SSCD underwent MFC repair. There was significant postoperative resolution in all symptoms (P0.0001). Laboratory 25-hydroxyvitamin D values correlated with preoperative aural fullness (rCertain metabolic markers may predict SSCD presentation before and after surgery. Previous history of osteoporosis, autoimmune conditions, or arthritis may play a role in SSCD pathophysiology and can help predict clinical outcomes. Future evaluation should take metabolic laboratory values and acquire an exact medical history.
- Published
- 2022
48. Intratympanic Injection for Autoimmune Inner Ear Disease (AIED)
- Author
-
Janssen Services, LLC
- Published
- 2013
49. Labyrinthine Fistulae in Squamosal Type of Chronic Otitis Media: Therapeutic Outcome.
- Author
-
Misale, Priyanka, Lepcha, Anjali, Chandrasekharan, Ramanathan, and Manusrut, Manusrut
- Subjects
- *
OTOSCLEROSIS , *OTITIS media , *FISTULA , *DEAFNESS , *VERTIGO , *DISEASE complications - Abstract
Introduction: Labyrinthine fistulae (LF) are the common complications of chronic otitis media (COM) of squamosal variety. The final therapeutic outcome of this condition is to preserve the cochlear and vestibular functions. Herein, we present the data of the cases managed at our institute with respect to their presenting complaints, adopted therapeutic approaches and outcomes. Materials and Methods: A retrospective chart review was conducted on all cases with COM squamosal type in adult patients. A total of 275 patients were reviewed, out of whom 30 cases had LF. The results were mainly studied with respect to the postoperative improvement of hearing and vertigo. Results: The incidence rate of LF in the present study was obtained at 10.9%. Only 50% of the cases had the symptoms of vertigo. Furthermore, positive fistula test was elicited in 3.3% of the cases. All cases undergoing preoperative imaging were diagnosed successfully. In addition, 42.85% of the cases had profound hearing loss preoperatively, which sustained after the operation. However, 47.61% of the cases showed an improvement of at least ≥ 10 dB in the air-bone gap. Out of the 15 LF cases with vertigo as the main complaint, only 11 cases referred for follow-up. In this regard, 63.63% of the cases had no postoperative vertigo symptoms. Conclusion: Patients with LF may not have complaints of vertigo and a positive fistula sign upon admission. Preoperative imaging facilitates the diagnosis of this condition. The removal of the matrix under constant irrigation, followed by repair with bone wax and/or autologous tissue, is sufficient to preserve the cochlear and vestibular symptoms postoperatively. [ABSTRACT FROM AUTHOR]
- Published
- 2019
50. Does Otovestibular Loss in the Autosomal Dominant Disorder DFNA9 Have an Impact of on Cognition? A Systematic Review
- Author
-
Jonas De Belder, Stijn Matthysen, Annes J. Claes, Griet Mertens, Paul Van de Heyning, and Vincent Van Rompaey
- Subjects
DFNA9 ,cognition ,systematic review ,quality of life ,labyrinth diseases ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Background and Purpose: Cognitive impairment has been observed in patients with bilateral vestibular loss (BVL) and in patients with sensorineural hearing loss (SNHL). DFNA9 is an autosomal dominant disorder that causes a combination of both sensory deficits by the 3rd to 5th decade. We therefore hypothesize a combined detrimental effect on cognition. The aim of this systematic review was to identify studies related to DFNA9 in general and its relationship with cognitive impairment more specifically.Materials and Methods: Several databases including Medline, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, ISI Web of Knowledge, and Web of Science were searched to accumulate information about DFNA9-mutations, including phenotype, genotype, pathophysiology, quality of life (QOL), and imaging in general and cognitive function more specifically. A qualitative analysis was performed on the 55 articles that qualified.Results: The clinical features of DFNA9 are different along the 24 COCH mutations, described up to now. Vestibular symptoms generally present themselves a few years after SNHL onset in mutations associated with the vWFA-domain although they can precede SNHL onset in other mutations associated with the LCCL-domain. QoL has not been studied extensively in DFNA9, although scarce work is available on the positive impact of cochlear implantation to rehabilitate hearing. No studies were found evaluating cognition in DFNA9 patients.Conclusion: Although cognitive impairment has been demonstrated in patients with hearing loss as well as in patients with BVL, no studies have been reported on the combination of both sensory deficits, such as in DFNA9. Further research is warranted to correlate otovestibular status with cognition.
- Published
- 2018
- Full Text
- View/download PDF
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