25 results on '"Laboratory examinations"'
Search Results
2. Self-Supervised Learning-Based General Laboratory Progress Pretrained Model for Cardiovascular Event Detection
- Author
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Li-Chin Chen, Kuo-Hsuan Hung, Yi-Ju Tseng, Hsin-Yao Wang, Tse-Min Lu, Wei-Chieh Huang, and Yu Tsao
- Subjects
Cardiovascular diseases ,cardiometabolic disease ,disease progression ,laboratory examinations ,time-series data ,pre-train model ,Computer applications to medicine. Medical informatics ,R858-859.7 ,Medical technology ,R855-855.5 - Abstract
Objective: Leveraging patient data through machine learning techniques in disease care offers a multitude of substantial benefits. Nonetheless, the inherent nature of patient data poses several challenges. Prevalent cases amass substantial longitudinal data owing to their patient volume and consistent follow-ups, however, longitudinal laboratory data are renowned for their irregularity, temporality, absenteeism, and sparsity; In contrast, recruitment for rare or specific cases is often constrained due to their limited patient size and episodic observations. This study employed self-supervised learning (SSL) to pretrain a generalized laboratory progress (GLP) model that captures the overall progression of six common laboratory markers in prevalent cardiovascular cases, with the intention of transferring this knowledge to aid in the detection of specific cardiovascular event. Methods and procedures: GLP implemented a two-stage training approach, leveraging the information embedded within interpolated data and amplify the performance of SSL. After GLP pretraining, it is transferred for target vessel revascularization (TVR) detection. Results: The proposed two-stage training improved the performance of pure SSL, and the transferability of GLP exhibited distinctiveness. After GLP processing, the classification exhibited a notable enhancement, with averaged accuracy rising from 0.63 to 0.90. All evaluated metrics demonstrated substantial superiority ( ${p} < 0.01$ ) compared to prior GLP processing. Conclusion: Our study effectively engages in translational engineering by transferring patient progression of cardiovascular laboratory parameters from one patient group to another, transcending the limitations of data availability. The transferability of disease progression optimized the strategies of examinations and treatments, and improves patient prognosis while using commonly available laboratory parameters. The potential for expanding this approach to encompass other diseases holds great promise. Clinical impact: Our study effectively transposes patient progression from one cohort to another, surpassing the constraints of episodic observation. The transferability of disease progression contributed to cardiovascular event assessment.
- Published
- 2024
- Full Text
- View/download PDF
3. ETIOLOGY AND EPIDEMIOLOGY OF DEATHS CAUSED BY INTOXICATIONS WITHIN THE FORENSIC DEPARTMENT OF SIBIU COUNTY.
- Author
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CIOCÎRLAN, MARIA and TOPÎRCEAN, ELENA
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- *
ETIOLOGY of diseases , *VIOLENT deaths , *EPIDEMIOLOGY , *FORENSIC medicine , *PERSONALLY identifiable information - Abstract
In Romania, 7.9% in men and 3.8% in women of the general population have used cannabis at least once in their lives. The purpose of this paper is to highlight and evaluate aspects regarding the etiology and epidemiology of lethal cases caused by intoxications using case studies provided by the Sibiu Forensic Medicine Service. The case showcases a period of 10 years (2010-2019), documented within the archives of the service, where personal data of the deceased, as well as causal aspects of the death, are recorded. The present paper includes 169 cases in which the intoxication had a lethal result, registered at the Sibiu Forensic Medicine Service between 2010-2019. Out of the total deaths in the same period (3,355), deaths from intoxication represent a percentage of 5.04%, and of the total violent deaths a percentage of 8.68%. Prevention is the most effective method of combating intoxication. [ABSTRACT FROM AUTHOR]
- Published
- 2023
4. A multi‐year evaluation of medical student performance on and perceptions of collaborative gross anatomy laboratory examinations.
- Author
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VanLeuven, Ariel J., Szymik, Brett G., Ramsey, Lynn M., and Hesse, DeLoris Wenzel
- Abstract
Collaborative testing and its benefits have been reported in diverse disciplines across different types of academic institutions. However, there has been minimal research conducted on collaborative assessments in medical schools, particularly in the gross anatomy laboratory. The objectives of this study were to explore the effect of collaborative anatomy laboratory examinations on student performance and to gauge student perceptions of this assessment format. This study examined five academic years of medical students' performance on a two‐stage, collaborative anatomy laboratory examination wherein each student's overall score was a weighted combination of scores from the individual and team examination. Analyses of a descriptive survey capturing students' perceptions of the assessment method were also performed. Individual examination averages increased since implementing the collaborative assessment (p < 0.001), and team examination averages were higher than individual examination averages (p < 0.001). Teams outperformed each of their team members 98% of the time. Teams had a greater than 0.90 incidence of answering a question correctly if more than one person in the group got the answer correct on the individual portion, and a 0.66 incidence of answering correctly if only one person in their group answered correctly on the individual portion. Student feedback identified the discussions and learning that took place during the team portion to be a beneficial feature of this assessment format. Students also reported that this collaborative assessment made them feel a higher level of responsibility to perform well, and that it improved their understanding of gross anatomy. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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- View/download PDF
5. Veterinary Clinical Toxicology
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Gupta, PK and Gupta, PK
- Published
- 2019
- Full Text
- View/download PDF
6. LABORATÓRNE VYŠETRENIA VYUŽÍVANÉ PRE DIAGNOSTIKU ENDOKRINOLOGICKÝCH OCHORENÍ Z POHĽADU ANALÝZY DÁT ZDRAVOTNEJ POISŤOVNE.
- Author
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Ján, BIELIK and Peter, GLATZ
- Abstract
Copyright of Zdravotnicke listy is the property of Alexander Dubcek University in Trencin, Faculty of Nursing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2021
7. The liver fibrosis index is superior to the APRI and FIB-4 for predicting liver fibrosis in chronic hepatitis B patients in China
- Author
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Dedong Huang, Taofa Lin, Shaoyang Wang, Lieyun Cheng, Liping Xie, Youguang Lu, Muxing Chen, Lingling Zhu, and Jie Shi
- Subjects
Hepatitis B ,Laboratory examinations ,Liver fibrosis ,Ultrasound elastography ,APRI ,FIB-4 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background The purpose of this study was to prospectively investigate the value of real-time ultrasound elastography (RTE) for the diagnosis of liver fibrosis (LF) in patients with chronic hepatitis B (CHB), to correlate the elastography findings with the histologic stage of LF and to compare RTE findings with those from noninvasive tests of LF calculated using laboratory blood parameters. Methods Liver biopsies, laboratory blood testing, and RTE were performed in 91 patients with CHB. The LF index (LFI) was calculated using a multiple linear regression equation involving 11 parameters, which represented the degree of LF. The higher the LFI is, the greater the degree of LF. Results The mean aspartate aminotransferase-to-platelet ratio index (APRI) and the mean fibrosis index based on four factors (FIB-4) were significantly different for the 5 stages of LF, respectively. The APRI (r = 0.43, P = 0.006), FIB-4 (r = 0.51, P = 0.012) and LFI (r = 0.562, P = 0.004) were correlated with the stages of LF. For discriminating stage F0 from F1, only the LFI had significant power (P = 0.026) for predicting stage F1. For discriminating stage F4 from F3, only the LFI had statistically significant power (P = 0.024) in predicting stage F4. The areas under the receiver operating characteristic curves (AUCs) of the LFI for diagnosing significant, advanced LF and liver cirrhosis were significantly higher than those of the APRI and FIB-4, and the LFI had better sensitivity and specificity. Conclusions The LFI calculated by RTE is reliable for the assessment of LF in patients with CHB and has better discrimination power than the APRI and FIB-4.
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- 2019
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8. Case report: Experience and insights on the treatment of two cases of cryptococcal meningitis during the later stages of the COVID-19 pandemic.
- Author
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Zhou Y, Qiu B, Jiang J, Chen T, Wang L, Yang Y, Ruan S, Chen Y, Fang H, Jin J, and Yang N
- Subjects
- Humans, Male, Middle Aged, Female, Coinfection, Adult, Cryptococcus neoformans isolation & purification, Treatment Outcome, Meningitis, Cryptococcal drug therapy, Meningitis, Cryptococcal diagnosis, COVID-19 complications, COVID-19 epidemiology, SARS-CoV-2, Antifungal Agents therapeutic use
- Abstract
In the late stages of the COVID-19 pandemic, there's an increasing trend in opportunistic infections, including bacterial and fungal infections. This study discusses the treatment process of two cases of cryptococcal meningitis during the COVID-19 pandemic. It highlights the importance of laboratory testing for these co-infections and stresses the need for vigilance, early diagnosis, and proactive treatment to improve patient outcomes in the post-pandemic era., Competing Interests: Author JJiang was employed by Guilin URIT Medical Electronic Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Zhou, Qiu, Jiang, Chen, Wang, Yang, Ruan, Chen, Fang, Jin and Yang.)
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- 2024
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9. Variability between testing methods for SARS-CoV-2 nucleic acid detection 16 days post-discharge: a case report.
- Author
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Hu, Qiongying, Yang, Xue, Gao, Peiyang, Tang, Jianyuan, Liu, Qingxiao, Du, Qiurong, Yang, Fujie, Wu, Cheng, Liu, Li, Bi, Dongming, and Xiong, DaQian
- Subjects
- *
NUCLEIC acids , *LYMPHOCYTE count , *COVID-19 - Abstract
Keywords: coronavirus disease 2019; laboratory examinations; nucleic acid detection; severe acute respiratory syndrome coronavirus 2 EN coronavirus disease 2019 laboratory examinations nucleic acid detection severe acute respiratory syndrome coronavirus 2 e123 e127 5 07/13/20 20200801 NES 200801 To the Editor, By March 17, 2020, there were 80,881 cumulative confirmed cases, 128 suspected cases and 3226 deaths reported by the National Health Commission of the People's Republic of China [[1]]. Because the Daan (N and ORF1ab) detected a single viral nucleic acid in the throat swab (Sample number: 2020021707) as shown in Table 2, the interpretation was considered not indicative of COVID-19 according to the 'Laboratory guidelines for novel coronavirus pneumonia (version 4)' [[5]]. In summary, based on the current situation of novel coronavirus nucleic acid detection, the outcomes of patients with isolation treatment need to be supported by more clinical evidence. Coronavirus disease 2019, laboratory examinations, nucleic acid detection, severe acute respiratory syndrome coronavirus 2. [Extracted from the article]
- Published
- 2020
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10. Clinical Study on 136 Children with Sudden Sensorineural Hearing Loss
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Feng-Jiao Li, Da-Yong Wang, Hong-Yang Wang, Li Wang, Feng-Bo Yang, Lan Lan, Jing Guan, Zi-Fang Yin, Ulf Rosenhall, Lan Yu, Sten Hellstrom, Xi-Jun Xue, Mao-Li Duan, and Qiu-Ju Wang
- Subjects
Audiological Characteristics ,Children ,Laboratory Examinations ,Prognostic Factors ,Sudden Hearing Loss ,Medicine - Abstract
Background: The prevalence of sudden sensorineural hearing loss in children (CSSNHL) is consistently increasing. However, the pathology and prognosis of CSSNHL are still poorly understood. This retrospective study evaluated clinical characteristics and possible associated factors of CSSNHL. Methods: One hundred and thirty-six CSSNHL patients treated in Department of Otolaryngology-Head and Neck Surgery and Institute of Otolaryngology at Chinese PLA General Hospital between July 2008 and August 2015 were included in this study. These patients were analyzed for clinical characteristics, audiological characteristics, laboratory examinations, and prognostic factors. Results: Among the 136 patients (151 ears), 121 patients (121 ears, 80.1%) were diagnosed with unilaterally CSSNHL, and 15 patients (30 ears, 19.9%) with bilateral CSSNHL. The complete recovery rate of CSSNHL was 9.3%, and the overall recovery rate was 37.7%. We found that initial degree of hearing loss, onset of treatment, tinnitus, the ascending type audiogram, gender, side of hearing loss, the recorded auditory brainstem response (ABR), and distortion product otoacoustic emissions (DPOAEs) had prognostic significance. Age, ear fullness, and vertigo had no significant correlation with recovery. Furthermore, the relevant blood tests showed 30.8% of the children had abnormal white blood cell (WBC) counts, 22.1% had elevated homocysteine levels, 65.8% had high alkaline phosphatase (ALP), 33.8% had high IgE antibody levels, and 86.1% had positive cytomegalovirus (CMV) IgG antibodies. Conclusions: CSSNHL commonly occurs unilaterally and results in severe hearing loss. Initial severe hearing loss and bilateral hearing loss are negative prognostic factors for hearing recovery, while positive prognostic factors include tinnitus, gender, the ascending type audiogram, early treatment, identifiable ABR waves, and DPOAEs. Age, vertigo, and ear fullness are not correlated with the recovery. Some serologic indicators, including the level of WBC, platelet, homocysteine, ALP, positive CMV IgG antibody, fibrinogen, and some immunologic indicators, are closely related to CSSNHL.
- Published
- 2016
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11. Diagnostic characteristics of supplemental laboratory criteria for incomplete Kawasaki disease in children with complete Kawasaki disease
- Author
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Hyun Ok Jun, Jeong Jin Yu, So Yeon Kang, Chang Deok Seo, Jae Suk Baek, Young-Hwue Kim, and Jae-Kon Ko
- Subjects
Kawasaki disease ,Incomplete Kawasaki disease ,Laboratory examinations ,Diagnosis of Kawasaki disease ,Pediatrics ,RJ1-570 - Abstract
PurposeIn 2004, the American Heart Association (AHA) had published an algorithm for the diagnosis of incomplete Kawasaki disease (KD). The aim of the present study was to investigate characteristics of supplemental laboratory criteria in this algorithm.MethodsWe retrospectively examined the medical records of 355 patients with KD who were treated with intravenous immunoglobulin (IVIG) during the acute phase of the disease. Laboratory data were obtained before the initial IVIG administration and up to 10 days after fever onset. In 106 patients, laboratory testing was performed more than twice.ResultsThe AHA supplemental laboratory criteria were fulfilled in 90 patients (25.4%), and the frequency of laboratory examination (odds ratio [OR], 1.981; 95% confidence interval [CI], 1.391-2.821; P
- Published
- 2015
- Full Text
- View/download PDF
12. Self-Supervised Learning-Based General Laboratory Progress Pretrained Model for Cardiovascular Event Detection.
- Author
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Chen LC, Hung KH, Tseng YJ, Wang HY, Lu TM, Huang WC, and Tsao Y
- Subjects
- Humans, Benchmarking, Disease Progression, Supervised Machine Learning, Absenteeism, Cardiovascular Diseases diagnosis
- Abstract
Objective: Leveraging patient data through machine learning techniques in disease care offers a multitude of substantial benefits. Nonetheless, the inherent nature of patient data poses several challenges. Prevalent cases amass substantial longitudinal data owing to their patient volume and consistent follow-ups, however, longitudinal laboratory data are renowned for their irregularity, temporality, absenteeism, and sparsity; In contrast, recruitment for rare or specific cases is often constrained due to their limited patient size and episodic observations. This study employed self-supervised learning (SSL) to pretrain a generalized laboratory progress (GLP) model that captures the overall progression of six common laboratory markers in prevalent cardiovascular cases, with the intention of transferring this knowledge to aid in the detection of specific cardiovascular event., Methods and Procedures: GLP implemented a two-stage training approach, leveraging the information embedded within interpolated data and amplify the performance of SSL. After GLP pretraining, it is transferred for target vessel revascularization (TVR) detection., Results: The proposed two-stage training improved the performance of pure SSL, and the transferability of GLP exhibited distinctiveness. After GLP processing, the classification exhibited a notable enhancement, with averaged accuracy rising from 0.63 to 0.90. All evaluated metrics demonstrated substantial superiority ([Formula: see text]) compared to prior GLP processing., Conclusion: Our study effectively engages in translational engineering by transferring patient progression of cardiovascular laboratory parameters from one patient group to another, transcending the limitations of data availability. The transferability of disease progression optimized the strategies of examinations and treatments, and improves patient prognosis while using commonly available laboratory parameters. The potential for expanding this approach to encompass other diseases holds great promise., Clinical Impact: Our study effectively transposes patient progression from one cohort to another, surpassing the constraints of episodic observation. The transferability of disease progression contributed to cardiovascular event assessment., (© 2023 The Authors.)
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- 2023
- Full Text
- View/download PDF
13. THE COST EFFECTIVENESS OF SPECIALIZED LABORATORY DIAGNOSTIC METHODS IN HEALTHCARE.
- Author
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MELUŠ, Vladimír, ĎUĎÁKOVÁ, Zuzana, KAŠLÍKOVÁ, Katarína, KRAJČOVIČOVÁ, Zdenka, SLOBODNÍKOVÁ, Jana, and RECHITSKII, Aleksei Sergeevich
- Subjects
COST effectiveness ,MEDICAL laboratories ,LABORATORIES ,ACCOUNTING ,MEDICAL care - Abstract
Laboratory investigative methods in the health sector currently have sophisticated methods and reliable procedures. However, individual labs must take into account their real financial possibilities so that they do not reach negative economic figures. In our paper we evaluate the adequacy of the numbers of IgG, IGA, IgM, immunofixation and total protein examinations realized in patients with hematooncological diseases. The obtained data are confronted with current economic possibilities of medical laboratories. [ABSTRACT FROM AUTHOR]
- Published
- 2019
14. Influence of the Plow Filling and Thread Angle onto the Plow Head Efficiency / Wpływ Współczynnika Wypełnienia Organu Oraz Kąta Nawinięcia Płata Ślimaka Na Sprawność Ładowania Frezującymi Organami Ślimakowymi
- Author
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Wydro, Tomasz
- Subjects
FASTENERS ,LONGWALL mining ,SCREW-threads ,EXAMINATIONS ,MECHANICAL efficiency - Abstract
Copyright of Archives of Mining Sciences is the property of Polish Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2015
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15. Generalisierte inflammatorische Epidermolysis bullosa acquisita bei initialem Virusexanthemverdacht.
- Author
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El-Haj, N., Micheli, C., Brunner, M., Zillikens, D., and Zouboulis, C.C.
- Abstract
Copyright of Der Hautarzt is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2014
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- View/download PDF
16. Laboratory assessment of the hypertensive individual. Value of the main guidelines for high blood pressure
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Rafael S. Reis, Isabela J. Benseñor, and Paulo A. Lotufo
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laboratory examinations ,high blood pressure ,obesity ,screening ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
OBJECTIVE: To determine if abnormal laboratory findings are more common in individuals with hypertension and in those with other risk factors, such as obesity, smoking and alcohol ingestion. METHODS: A study was carried out in the general outpatient clinics of a university hospital (145 individuals without previous diagnosis of hypertension) and the following variables were assessed: high blood pressure (as defined by the VI Joint National Committee on Prevention, Detection and Treatment of High Blood Pressure - VI JNC), obesity [calculated using body mass index (BMI)], tobacco use, and alcoholic ingestion. The laboratory examinations consisted of the following tests: hemogram, glycemia, uric acid, potassium, total/HDL-fraction cholesterol, triglycerides, calcium and creatinine. RESULTS: High blood pressure was not associated with a higher number of abnormal laboratory tests. Hypertensive individuals with a BMI > or = 25kg/m² or normotensive obese individuals, however, had a higher frequency of diabetes (12X), hypertriglyceridemia (3X), and hypercholesterolemia (2X), as compared with hypertensive individuals with BMI
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- 1999
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17. Chronic spontaneous urticaria in clinical practice: a pilot survey about attitudes and perceptions on assessment, diagnostic work-up and dietary management
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Antonio Cristaudo, Annamaria Offidani, Giovanni Genovese, Paolo Dapavo, Silvia Ferrucci, Eustachio Nettis, Annalisa Patrizi, Paolo D. Pigatto, Patrizia Pepe, Maria Teresa Fierro, Riccardo Asero, Ornella De Pità, Caterina Foti, Angelo V. Marzano, Nicoletta Cassano, Nunzio Crimi, Gino A. Vena, Luca Stingeni, and Giampiero Girolomoni
- Subjects
medicine.medical_specialty ,Urticaria ,MEDLINE ,Pilot survey ,Dermatology ,Assessment ,Clinical practice ,Guidelines ,Quality of life ,Surveys and Questionnaires ,Laboratory examinations ,medicine ,Humans ,Chronic Urticaria ,Medical prescription ,Disease severity ,business.industry ,Dietary management ,Chronic spontaneous urticaria ,Anti-thyroid autoantibodies ,Work-up ,Diet ,Clinical Practice ,Infectious Diseases ,Cross-Sectional Studies ,Attitude ,Family medicine ,Chronic Disease ,Quality of Life ,business - Abstract
BACKGROUND Chronic spontaneous urticaria (CSU) is a heterogeneous condition whose management can be complex and challenging. The 0bjectives is to evaluate physicians' attitudes regarding practical aspects of CSU management, including adherence to international guidelines, criteria and instruments for CSU assessment, prescription of laboratory investigations and role of dietary measures. METHODS A cross-sectional survey was conducted using a study-specific questionnaire. It was administered to a group of physicians with a specialist interest in CSU from different areas of Italy definable as "CSU experts" (Group A; n=21) and subsequently to other physicians who managed CSU only occasionally in their clinical activity (Group B; n=25). RESULTS The EAACI/GA²LEN/EDF/WAO guidelines were considered very or moderately useful by the majority of participants. Significantly more physicians in group A reported that such guidelines were always followed in clinical practice (P=0.0008). Instruments for the assessment of CSU severity/activity and quality of life were used in clinical practice significantly more often by CSU experts as compared to group B. Dietary measures were frequently suggested for CSU patients by nearly three quarters of group B members and by only 5% of CSU experts (P
- Published
- 2021
18. The liver fibrosis index is superior to the APRI and FIB-4 for predicting liver fibrosis in chronic hepatitis B patients in China
- Author
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Huang, Dedong, Lin, Taofa, Wang, Shaoyang, Cheng, Lieyun, Xie, Liping, Lu, Youguang, Chen, Muxing, Zhu, Lingling, and Shi, Jie
- Published
- 2019
- Full Text
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19. Effects of Prosthodontic Treatment on the A.D.L. of the Elderly Patients.
- Author
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Mori, Hiroki
- Subjects
GERIATRIC dentistry ,ACTIVITIES of daily living ,PROSTHODONTICS ,PROSTHETICS ,COMPLETE dentures ,COMPARATIVE studies ,THERAPEUTICS - Abstract
The article presents a comparative study on the effects of prosthodontic treatment on the activities of daily living (A.D.L) of the elderly patients. The study examines the relation between oral and general conditions of older patients with regards to the change in A.D.L before and after using of complete dentures. Results of the study suggest that the prosthodontic treatment could affect the elderly patients' A.D.L.
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- 1999
- Full Text
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20. Follow-up study of participants in an extensive health examination programme at a Swedish industry.
- Author
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Rose, G. and Bengtsson, C.
- Abstract
Two years after an extensive health examination at a Swedish industry, a follow-up study was carried out in 110 employees (94% of those initially examined). The control included a history of the subject's health, a physical examination, an electrocardiogram, urine and faeces examinations and 16 chemical analyses of whole blood or serum. Except for repeat examinations of those who had had initial values outside reference values, most of the chemical analyses meant nothing, leading to unnecessary expense and possible risk of either worried or complacent participants. The history and physical and laboratory examinations, aimed at finding factors which can be improved by changing the life style seem to be most beneficial. It is concluded that extensive health examinations, including a large number of laboratory examinations which are carried out at many industries as a health control, should be critically evaluated at these industries. [ABSTRACT FROM AUTHOR]
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- 1991
- Full Text
- View/download PDF
21. Diagnostic characteristics of supplemental laboratory criteria for incomplete Kawasaki disease in children with complete Kawasaki disease
- Author
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Young Hwue Kim, Jeong Jin Yu, Jae Suk Baek, Hyun Ok Jun, Chang Deok Seo, So Yeon Kang, and Jae Kon Ko
- Subjects
Diagnosis of Kawasaki disease ,Pediatrics ,medicine.medical_specialty ,Kawasaki disease ,business.industry ,Medical record ,lcsh:RJ1-570 ,lcsh:Pediatrics ,Odds ratio ,Disease ,medicine.disease ,Laboratory testing ,Confidence interval ,Laboratory examination ,Coronary arteries ,medicine.anatomical_structure ,Incomplete Kawasaki disease ,Pediatrics, Perinatology and Child Health ,Laboratory examinations ,Medicine ,Original Article ,business - Abstract
Purpose: In 2004, the American Heart Association (AHA) had published an algorithm for the diagnosis of incomplete Kawasaki disease (KD). The aim of the present study was to investigate characteristics of supplemental laboratory criteria in this algorithm. Methods: We retrospectively examined the medical records of 355 patients with KD who were treated with intravenous immunoglobulin (IVIG) during the acute phase of the disease. Laboratory data were obtained before the initial IVIG administration and up to 10 days after fever onset. In 106 patients, labo ratory testing was performed more than twice. Results: The AHA supplemental laboratory criteria were fulfilled in 90 patients (25.4%), and the frequ ency of laboratory examination (odds ratio [OR], 1.981; 95% confidence interval [CI], 1.391–2.821; P
- Published
- 2015
22. Why does the clinical diagnosis fail in suspected appendicitis?
- Author
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Andersson, Roland, Hugander, AP, Ghazi, SH, Ravn, H, Offenbartl, SK, Nyström, Per-Olof, Olaison, Gunnar, Andersson, Roland, Hugander, AP, Ghazi, SH, Ravn, H, Offenbartl, SK, Nyström, Per-Olof, and Olaison, Gunnar
- Abstract
Objective: To identify systematic errors in surgeons' estimations of the importance of diagnostic variables in the decision to explore patients with suspected appendicitis. Design: Prospective case series. Setting: Two emergency departments, Sweden. Patients: 496 patients with suspected appendicitis on admission, of whom 194 had a correct operation for appendicitis and 59 had a negative exploration. Main outcome measures: Predictors of a negative exploration expressed as the odds ratio (OR) for negative exploration. Variables influence on the decision to operate, expressed as the OR for operation, compared with the true diagnostic importance, expressed as the OR for appendicitis. Results: Predictors of negative explorations were high ratings in variables describing pain and tenderness (patient's perceived pain, abdominal tenderness, rebound tenderness, guarding or rectal tenderness), weak or absent inflammatory response, female sex, long duration of symptoms and absence of vomiting, with OR of 1.8-3.0. Pain and tenderness had too strong an influence on the decision to operate whereas the lack of an inflammatory response, no vomiting, and long duration of symptoms were not given enough attention. There was no sex difference in the proportion of patients with non-surgical abdominal pain (NSAP) who were operated on, but NSAP was more common and appendicitis less common among women, leading to a larger proportion of negative appendicectomies among women. Conclusion: Negative explorations in patients with suspected appendicitis are related to systematic errors in the clinical diagnosis with too strong an emphasis on pain and tenderness, and too little attention paid to duration of symptoms and objective signs of inflammation. Rectal tenderness is not a sign of appendicitis. The risk of diagnostic errors is similar in men and women.
- Published
- 2000
23. OCENJEVANJE SOMATOSENZORIČNEGA SISTEMA.
- Author
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Rodi, Zoran
- Subjects
SOMATOSENSORY cortex ,NEUROPHYSIOLOGY ,NEURAL conduction ,PERIPHERAL neuropathy ,EVOKED potentials (Electrophysiology) ,CLINICAL trials - Abstract
Copyright of Rehabilitation / Rehabilitacija is the property of University Rehabilitation Institute, Republic of Slovenia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2012
24. DTIC (Dacarbazine)-induced hepatic damage.
- Author
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Czarnetzki, Beate and Macher, Egon
- Published
- 1981
- Full Text
- View/download PDF
25. Diagnostic characteristics of supplemental laboratory criteria for incomplete Kawasaki disease in children with complete Kawasaki disease.
- Author
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Jun HO, Yu JJ, Kang SY, Seo CD, Baek JS, Kim YH, and Ko JK
- Abstract
Purpose: In 2004, the American Heart Association (AHA) had published an algorithm for the diagnosis of incomplete Kawasaki disease (KD). The aim of the present study was to investigate characteristics of supplemental laboratory criteria in this algorithm., Methods: We retrospectively examined the medical records of 355 patients with KD who were treated with intravenous immunoglobulin (IVIG) during the acute phase of the disease. Laboratory data were obtained before the initial IVIG administration and up to 10 days after fever onset. In 106 patients, laboratory testing was performed more than twice., Results: The AHA supplemental laboratory criteria were fulfilled in 90 patients (25.4%), and the frequency of laboratory examination (odds ratio [OR], 1.981; 95% confidence interval [CI], 1.391-2.821; P<0.001) was a significant predictor of it. The fulfillment of AHA supplemental laboratory criteria was significantly associated with refractoriness to the initial IVIG administration (OR, 2.388; 95% CI, 1.182-4.826; P=0.013) and dilatation of coronary arteries (OR, 2.776; 95% CI, 1.519-5.074; P=0.001)., Conclusion: Repeated laboratory testing increased the rate of fulfillment of the AHA supplemental laboratory criteria in children with KD.
- Published
- 2015
- Full Text
- View/download PDF
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