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3. Mixing time and cutoff for the weakly asymmetric simple exclusion process

Author

Labbé, C. and Lacoin, H.

Subjects
Mathematics - Probability, Mathematical Physics, 60J27 (Primary), 37A25, 82C22 (Secondary)
Abstract

We consider the simple exclusion process with $k$ particles on a segment of length $N$ performing random walks with transition $p>1/2$ to the right and $q=1-p$ to the left. We focus on the case where the asymmetry in the jump rates $b=p-q>0$ vanishes in the limit when $N$ and $k$ tend to infinity, and obtain sharp asymptotics for the mixing times of this sequence of Markov chains in the two cases where the asymmetry is either much larger or much smaller than $(\log k)/N$. We show that in the former case ($b \gg (\log k)/N$), the mixing time corresponds to the time needed to reach macroscopic equilibrium, like for the strongly asymmetric (i.e.\ constant $b$) case studied in [LL18], while the latter case ($b \ll (\log k)/N$) macroscopic equilibrium is not sufficient for mixing and one must wait till local fluctuations equilibrate, similarly to what happens in the symmetric case worked out in [Lac16b]. In both cases, convergence to equilibrium is abrupt: we have a cutoff phenomenon for the total-variation distance. We present a conjecture for the remaining regime when the asymmetry is of order $(\log k) / N$., Comment: 39 pages

Published
2018

4. The Nitrogen concentration effect on Ce doped SiOxNy emission: towards optimized Ce3+ for DEL applications

Author

Ehré, F, Labbé, C., Dufour, C, Jadwisienczak, W, Weimmerskirch-Aubatin, J., Portier, X, Doualan, J. -L, Cardin, J, Richard, A., Ingram, D, Labrugère, C, and Gourbilleau, F

Subjects
Condensed Matter - Materials Science, Physics - Computational Physics, Physics - Optics
Abstract

Ce-doped SiO x N y films are deposited by magnetron reactive sputtering from a CeO 2 target under nitrogen reactive gas atmosphere. Visible photoluminescence measurements regarding the nitrogen gas flow reveal a large emission band centered at 450 nm for a sample deposited under a 2 sccm flow. A special attention is paid to the origin of such an emission at high nitrogen concentration. Different emitting centers are suggested in Ce doped SiO x N y films (e.g. band tails, CeO 2, Ce clusters, Ce 3+ ions), with different activation scenarios to explain the luminescence. X-ray photoelectron spectroscopy (XPS) reveals the exclusive presence of Ce 3+ ions whatever the nitrogen or Ce concentrations, while transmission electron microscopy (TEM) shows no clusters or silicates upon high temperature annealing. With the help of photoluminescence excitation spectroscopy (PLE), a wide excitation range from 250 nm up to 400 nm is revealed and various excitations of Ce 3+ ions are proposed involving direct or indirect mechanisms. Nitrogen concentration plays an important role on Ce 3+ emission by modifying Ce surroundings, reducing the Si phase volume in SiO x N y and causing a nephelauxetic effect. Taking into account the optimized nitrogen growth parameters, the Ce concentration is analyzed as new parameter. Under UV excitation, a strong emission is visible to the naked eye with high Ce 3+ concentration (6 at. %). No saturation of the photoluminescence intensity is observed, confirming again the lack of Ce cluster or silicate phase formation due do the nitrogen presence., Comment: Nanoscale, Royal Society of Chemistry, 2018

Published
2018
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14. P2.17-07 Real-world Safety and Dosing of Lurbinectedin-Treated Patients with Small Cell Lung Cancer: Jazz EMERGE 402 Preliminary Analysis

Author

Halmos, B., primary, Lammers, P., additional, Patel, M., additional, Shapira, I., additional, Shunyakov, L., additional, Slater, D., additional, Labbé, C., additional, Naveh, N., additional, Boccuti, A., additional, Hanvesakul, R., additional, Li, W., additional, Rengarajan, B., additional, and Badin, F., additional

Published
2023
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25. EP16.03-020 High Tumor Mutational Burden by Whole-Genome Sequencing in Resected NSCLC in Never Smokers is Associated with Worse Prognosis

Author

Ruel, L.-J., primary, Li, Z., additional, Gaudreault, N., additional, Henry, C., additional, Armero, V.S., additional, Boudreau, D.K., additional, Zhang, T., additional, Landi, M.T., additional, Labbé, C., additional, Couture, C., additional, Desmeules, P., additional, Joubert, P., additional, and Bossé, Y., additional

Published
2022
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31. Visualization of Distributed Applications for Performance Debugging

Author

Ottogalli, F.-G., Labbé, C., Olive, V., de Oliveira Stein, B., de Kergommeaux, J. Chassin, Vincent, J.-M., Goos, G., editor, Hartmanis, J., editor, van Leeuwen, J., editor, Alexandrov, Vassil N., editor, Dongarra, Jack J., editor, Juliano, Benjoe A., editor, Renner, René S., editor, and Tan, C. J. Kenneth, editor

Published
2001
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33. Additional file 1 of Formation of intracellular vesicles within the Gram+ Lactococcus lactis induced by the overexpression of Caveolin-1β

Author

Flourieusse, A., Bourgeois, P., Schenckbecher, E., Palvair, J., Legrand, D., Labbé, C., Bescond, T., Avoscan, L., Orlowski, S., Rouleau, A., and Frelet-Barrand, A.

Abstract

Additional file 1: Figure S1. Expression of HTC in L. lactis after 4 hours post-induction by nisin. Total membrane proteins (5 µg for panel A, 5 and 10 µg for panel B) were separated in a 12% SDS–PAGE and analyzed by Western blot performed using either an antibody specific to caveolin-1 (A; 1/7500) or an HRP-conjugate specific to the His-tag affinity tag (B; 1/5000). A positive control protein containing caveolin-1β (C+) and the band of 75 kDa of the molecular weight from Bio-Rad (constitutively His-tagged) were used to estimate the expression levels of the recombinant proteins. H means membrane proteins derived from bacteria containing the recombinant pNZ-HTC vector, C- means crude membrane proteins derived from control bacteria containing the empty pNZ8148 vector, * means samples loaded without boiling step. o,d,m correspond respectively to oligomer, dimer and monomer. Western blot images are merged images of both colorimetric analysis of membranes revealing the molecular weights and chemiluminescent analysis revealing only some molecular weight bands. Figure S2. The red spots depict the intracellular caveolar vesicles, whose number is to be evaluated from their count observed by electron microscopy using a thin slice of the cell. The L. lactis cell (blue) is considered as a sphere of diameter 2r, and the slice cut for electron microscopy observation (black and grey) is considered as an equatorial cylinder of diameter 2r and thickness h (h = 90 nm). Cell volume is : V = (4/3) π r3 ; cylinder volume is : v = π r2 h. The volume ratio is : V/v = 4r/3h. Assuming 2r ≈ 10 h, V/v ≈ 7. In the case of the section is not in the equatorial plane of the cell, the ratio V/v is even slightly larger.

Published
2022
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37. Formation of intracellular vesicles within the Gram+Lactococcus lactis induced by the overexpression of Caveolin-1β.

Author

Flourieusse, A., Bourgeois, P., Schenckbecher, E., Palvair, J., Legrand, D., Labbé, C., Bescond, T., Avoscan, L., Orlowski, S., Rouleau, A., and Frelet-Barrand, A.

Subjects
ESCHERICHIA coli, MEMBRANE proteins, LACTOCOCCUS lactis, BIOLOGICAL membranes, MEMBRANE lipids, GENETIC overexpression, TOXOPLASMA gondii, LACTOCOCCUS
Abstract

Background: Caveolae are invaginated plasma membrane domains of 50–100 nm in diameter involved in many important physiological functions in eukaryotic cells. They are composed of different proteins, including the membrane-embedded caveolins and the peripheric cavins. Caveolin-1 has already been expressed in various expression systems (E. coli, insect cells, Toxoplasma gondii, cell-free system), generating intracellular caveolin-enriched vesicles in E. coli, insect cells and T. gondii. These systems helped to understand the protein insertion within the membrane and its oligomerization. There is still need for fundamental insights into the formation of specific domains on membrane, the deformation of a biological membrane driven by caveolin-1, the organization of a caveolar coat, and the requirement of specific lipids and proteins during the process. The aim of this study was to test whether the heterologously expressed caveolin-1β was able to induce the formation of intracellular vesicles within a Gram+ bacterium, Lactococcus lactis, since it displays a specific lipid composition different from E. coli and appears to emerge as a good alternative to E. coli for efficient overexpression of various membrane proteins. Results: Recombinant bacteria transformed with the plasmid pNZ-HTC coding for the canine isoform of caveolin-1β were shown to produce caveolin-1β, in its functional oligomeric form, at a high expression level unexpected for an eukaryotic membrane protein. Electron microscopy revealed several intracellular vesicles from 30 to 60 nm, a size comparable to E. coli h-caveolae, beneath the plasma membrane of the overexpressing bacteria, showing that caveolin-1β is sufficient to induce membrane vesiculation. Immunolabelling studies showed antibodies on such neo-formed intracellular vesicles, but none on plasma membrane. Density gradient fractionation allowed the correlation between detection of oligomers on Western blot and appearance of vesicles measurable by DLS, showing the requirement of caveolin-1β oligomerization for vesicle formation. Conclusions: Lactococcus lactis cells can heterologously overexpress caveolin-1β, generating caveolin-1β enriched intracellular neo-formed vesicles. These vesicles might be useful for potential co-expression of membrane proteins of pharmaceutical interest for their simplified functional characterization. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Stage IV ALK-Positive Lung Adenocarcinoma: 7.5-Year Complete Remission with Crizotinib

Author

Rouabhia D, Labbé C, Desmeules P, and Audet R

Subjects
Oncology, medicine.medical_specialty, Lung, Crizotinib, business.industry, Complete remission, ALK-Positive, General Medicine, medicine.disease, respiratory tract diseases, medicine.anatomical_structure, hemic and lymphatic diseases, Internal medicine, Medicine, Adenocarcinoma, Stage iv, business, medicine.drug
Abstract

Multiple lines of Anaplastic Lymphoma Kinase (ALK) Tyrosine Kinase Inhibitors (TKIs) are recommended for the treatment of ALK-positive Non-Small Cell Lung Cancer (NSCLC). This article provides an unusual case report of a 33-year-old male patient with a 91-month Progression-Free Survival (PFS) on a first-generation TKI, crizotinib.

Published
2021

44. Towards a white LED based on rare earth-doped ZnO

Author

Frieiro, J, Guillaume, C, López-Vidrier, J, Blázquez, O, González-Torres, S, Labbé, C, Hernández, S, Portier, Xavier, Garrido, B, Department of Electronics and Biomedical Engineering / Departament d'Enginyeria Electrònica i Biomèdica [Spain] (DEBE), Universitat de Barcelona (UB), Institute of Nanoscience and Nanotechnology (IN2UB), Universitat Autònoma de Barcelona (UAB), Nanomatériaux, Ions et Métamatériaux pour la Photonique (NIMPH), Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Condensed Matter::Materials Science, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci]
Abstract

International audience; By using ZnO thin films doped with Ce, Tb or Eu, deposited via radiofrequency magnetron sputtering, we have developed monochromatic (blue, green and red, respectively) light emitting devices (LEDs). The rare earth ions introduced with doping rates lower than 2% exhibit narrow and intense emission peaks due to electronic transitions in relaxation processes induced after electrical excitation. This study proves zinc oxide to be a good host for these elements, its high conductivity and optical transparency in the visible range being as well exploited as top transparent electrode. After structural characterization of the different doped layers, a device structure with intense electroluminescence is presented, modeled, and electrically and optically characterized. The different emission spectra obtained are compared in a chromatic diagram, providing a reference for future works with similar devices. The results hereby presented demonstrate three operating monochromatic LEDs, as well as a combination of the three species into another one, with a simply-designed structure compatible with current Si technology and demonstrating an integrated red-green-blue emission.

Published
2020

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