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4. Fecal microbiota composition is related to brown adipose tissue 18F-fluorodeoxyglucose uptake in young adults

Author

Ortiz-Alvarez, L., primary, Acosta, F. M., additional, Xu, H., additional, Sanchez-Delgado, G., additional, Vilchez-Vargas, R., additional, Link, A., additional, Plaza-Díaz, J., additional, Llamas, J. M., additional, Gil, A., additional, Labayen, I., additional, Rensen, P. C. N., additional, Ruiz, J. R., additional, and Martinez-Tellez, B., additional

Published
2022
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5. Effects of an exercise program on brain health outcomes for children with overweight or obesity

Author

Ortega, F.B., Mora-Gonzalez, J., Cadenas-Sanchez, C., Esteban-Cornejo, I., Migueles, J.H., Solis-Urra, P., Verdejo-Román, J., Rodriguez-Ayllon, M., Molina-Garcia, P., Ruiz, J.R., Martinez-Vizcaino, V., Hillman, C.H., Erickson, K.I., Kramer, A.F., Labayen, I., Catena, A., Ortega, F.B., Mora-Gonzalez, J., Cadenas-Sanchez, C., Esteban-Cornejo, I., Migueles, J.H., Solis-Urra, P., Verdejo-Román, J., Rodriguez-Ayllon, M., Molina-Garcia, P., Ruiz, J.R., Martinez-Vizcaino, V., Hillman, C.H., Erickson, K.I., Kramer, A.F., Labayen, I., and Catena, A.

Abstract

Importance Pediatric overweight and obesity are highly prevalent across the world, with implications for poorer cognitive and brain health. Exercise might potentially attenuate these adverse consequences. Objectives To investigate the effects of an exercise program on brain health indicators, including intelligence, executive function, academic performance, and brain outcomes, among children with overweight or obesity and to explore potential mediators and moderators of the main effects of exercise. Design, Setting, and Participants All preexercise and postexercise data for this 20-week randomized clinical trial of 109 children aged 8 to 11 years with overweight or obesity were collected from November 21, 2014, to June 30, 2016, with neuroimaging data processing and analyses conducted between June 1, 2017, and December 20, 2021. All 109 children were included in the intention-to-treat analyses; 90 children (82.6%) completed the postexercise evaluation and attended 70% or more of the recommended exercise sessions and were included in per-protocol analyses. Interventions All participants received lifestyle recommendations. The control group continued their usual routines, whereas the exercise group attended a minimum of 3 supervised 90-minute sessions per week in an out-of-school setting. Main Outcomes and Measures Intelligence, executive function (cognitive flexibility, inhibition, and working memory), and academic performance were assessed with standardized tests, and hippocampal volume was measured with magnetic resonance imaging. Results The 109 participants included 45 girls (41.3%); participants had a mean (SD) body mass index of 26.8 (3.6) and a mean (SD) age of 10.0 (1.1) years at baseline. In per-protocol analyses, the exercise intervention improved crystallized intelligence, with the exercise group improving from before exercise to after exercise (mean z score, 0.62 [95% CI, 0.44-0.80]) compared with the control group (mean z score, –0.10 [95% CI, –0.28 to 0

Published
2022

9. Hip and wrist accelerometers showed consistent associations with fitness and fatness in children aged 8‐12 years

Author

Leppänen, M. H., Migueles, J. H., Cadenas‐Sanchez, C., Henriksson, P., Mora‐Gonzalez, J., Henriksson, H., Labayen, I., Löf, M., Esteban‐Cornejo, I., and Ortega, F. B.

Subjects
waist accelerometers, adiposity, exercise, hyvinvointiteknologia, mittaus, liikemittarit, terveysteknologia, liikunta, lonkka, fyysinen kunto, aktiivisuusrannekkeet, mittauslaitteet, ranteet, physical fitness, hip accelerometers, kiihtyvyys
Abstract

Aim. Physical activity (PA) has traditionally been measured wearing accelerometers on the hip, but they are increasingly being worn on the wrist. We compared hip and wrist accelerometers with regard to their acceptability and any associations between PA and fatness and fitness. Methods. This cross‐sectional study comprised 103 children aged 8‐12 years (62% boys) who participated in the ActiveBrains trial by the University of Granada, Spain, in 2014‐2016. The children wore both ActiGraph GT3X+ hip and wrist accelerometers round the clock for seven days. The acceptability of both placements was evaluated by a questionnaire, while the children' fat mass index, waist circumference, and cardiorespiratory fitness (CRF) were assessed. Results. Wearing wrist accelerometers caused less disturbance, mainly because hip accelerometers caused more issues during the night. The measurements from both placements showed that lower PA levels were associated with fatness and that increased PA was associated with CRF. Conclusion. Both placements showed consistent results with regard to measuring associations between PA levels and fatness and fitness. However, wearing them on the wrist caused less discomfort at night. Future studies are needed to confirm the best placement for accelerometers during PA studies. peerReviewed

Published
2020

11. Time-course changes in macronutrient metabolism induced by a nutritionally balanced low-calorie diet in obese women

Author

Labayen, I., Diez, N., Parra, M.D., Gonzalez, A., and Martinez, J.A.

Subjects
Overweight persons, Metabolic diseases, Low-calorie diet, Food/cooking/nutrition
Abstract

The use of low-calorie diets is a common strategy for body-weight reduction purposes, but the time-course of the metabolic changes induced by moderately energy-restricted, otherwise balanced, diets is still poorly known. The aim of this nutritional intervention design was to study in obese women the effect of a balanced low-calorie diet on the metabolic rate, and metabolic fuel utilization changes during the weight loss process through the application of breath tests with stable isotope-labeled tracers. Seven obese (body mass index > 30 kg/[m.sup.2]) women were assigned to a 10-week dietary hypoenergetic intervention regime supplying 55% of energy as carbohydrate, 30% as fat and 15% as protein. Metabolic rate and substrate utilization were evaluated for 6 h in separate occasions during the weight loss program by indirect calorimetry and after [sup.13]C-labeled glucose, triolein and leucine administration. Body weight loss after 10 weeks was 4.2 [+ or -] 1.1 kg, while the percent body fat decrease was about 5%. Slimming was accompanied by a marked decrease in fasting leptin (about 25%). Postprandial carbohydrate utilization after the administration of a test meal with the same macronutrient distribution as the experimental low-energy diet was decreased (24.1%, P < 0.05) as a consequence of the dietary restriction, which was associated with lower insulin plasma levels (P < 0.05). Although protein and lipid oxidation were not significantly different after weight reduction (day 1 versus day 70), the metabolic utilization of these substrates tended to increase. Moreover, marginally significant indications obtained on days 15 and 45 suggest that the weight and body composition changes are attributable to a shift in endogenous and exogenous glucose utilization in favor of lipid burning. The breath tests determinations, which were performed on different occasions along the experimental trial, confirmed that the cumulative [sup.13]C output decreased for labeled tracers with time, being only statistically significant for the glucose utilization between days 15 and 45. In summary, the weight and fat mass losses were associated with a lower carbohydrate oxidation, which were probably compensated by an increase in lipid oxidation without major changes in protein mobilization.

Published
2004

17. Early life risk factors and their cumulative effects as predictors of overweight in Spanish children

Author

Iguacel, I., Escartín, L., Fernández-Alvira, J.M., Iglesia, I., Labayen, I., Moreno, L.A., Samper, M.P., Rodríguez, G., Herrero, D.A., Lorente, R.A., Otazu, M.J.Á., Sauras, M.L.Á., Navarro, T.A., Melendo, E.A., Casas, A.A., Clemos, C.B., Ledesma, M.V.B., Lalanza, M.L.B., Soler, T.B., Pérez-Aramendia, M.J.B., Cosculluela, P.B., Bravo, M.J.C., Raginal, R.C., Gimeno, M.I.C., Guerrero, T.C., Abadía, M.B.C., Mainar, M.C.C., Arenaz, M.D., Mayoral, L.C.E., Herréiz, C.E., Polo, Á.F., de Vargas Pastor, J.F., Pérez, M.T.F., Catalá, M.D.F., Domínguez, A.F., Fernández-Espinar, J.F., Rico, J.G., Sánchez-Ventura, J.G., Pérez, M.G., Sánchez, N.G., Vera, C.G., Moreno, A.-L.G., Gajón, M.A.G., Molina, C.J., Trevijano, B.K., Ara, M.L.L., Puértolas, M.J.L., Josa, M.P.L., Casamayor, E.L., Velillas, J.J.L., Gracia, M.ª.I.L., Botalla, R.M., Olloqui, M.M., Ibáñez, M.P.M., Bueno, J.L.M., Espligares, L.M., Gil, J.M.M., Hernández, I.M., Cosa, M.M., Aznar, L.A.M., Campos, A.I.M., Jalle, E.M., Serrano, E.M.N., Martínez, L.C.P., Fuentes, J.A.P., García, C.P., Del Val, P.P., Cuerpo, M.V.R., Pastora, R.R., Villagrasa, P.S., Gimeno, J.S., Zapater, A.S., Bonel, M.F.S., Bascuas, M.T.S., Jiménez, Viamonte, M.C.V., and Germes, G.Z.

Abstract

Objectives: To explore early life risk factors of overweight/obesity at age 6 years and their cumulative effects on overweight/obesity at ages 2, 4 and 6 years. Methods: Altogether 1031 Spanish children were evaluated at birth and during a 6-year follow-up. Early life risk factors included: parental overweight/obesity, parental origin/ethnicity, maternal smoking during pregnancy, gestational weight gain, gestational age, birth weight, caesarean section, breastfeeding practices and rapid infant weight gain collected via hospital records. Cumulative effects were assessed by adding up those early risk factors that significantly increased the risk of overweight/obesity. We conducted binary logistic regression models. Results: Rapid infant weight gain (OR 2.29, 99% CI 1.54–3.42), maternal overweight/obesity (OR 1.93, 99% CI 1.27–2.92), paternal overweight/obesity (OR 2.17, 99% CI 1.44–3.28), Latin American/Roma origin (OR 3.20, 99% CI 1.60–6.39) and smoking during pregnancy (OR 1.61, 99% CI 1.01–2.59) remained significant after adjusting for confounders. A higher number of early life risk factors accumulated was associated with overweight/obesity at age 6 years but not at age 2 and 4 years. Conclusions: Rapid infant weight gain, parental overweight/obesity, maternal smoking and origin/ethnicity predict childhood overweight/obesity and present cumulative effects. Monitoring children with rapid weight gain and supporting a healthy parental weight are important for childhood obesity prevention.

Published
2019

19. Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: the HELENA cross-sectional study

Author

Labayen, I., Ruiz, J. R., Huybrechts, I., Ortega, F. B., Arenaza, L., González-Gross, M., Widhalm, K., Molnar, D., Manios, Y., DeHenauw, S., Meirhaeghe, A., and Moreno, L. A.

Abstract

Background and aims The fat mass and obesity associated gene (FTO) has been associated with obesity and dietary intake. The aims were: (i) To assess whether energy and macronutrient intakes were different across the FTOrs9939609 genotypes in adolescents, and (ii) to explore whether dietary fat intake modified the association of the rs9939609 polymorphism with adiposity. Methods and results The FTOrs9939609 polymorphism was genotyped in 652 adolescents (53% females, 14.8 ± 1.2 years, TT = 246, TA = 296, AA = 110). Energy and macronutrient intake were assessed by two non-consecutive 24 h-recalls. Weight, height, waist circumference and skinfold thicknesses were measured and body fat percent was calculated. Energy and macronutrient intake were similar across the FTOrs9939609 genotypes (P > 0.2). There were significant interactions between the FTO polymorphism and fat intake on adiposity estimates (P < 0.05). In adolescents whose fat intake was below 30% (N = 203), the A allele of rs9939609 was not associated with adiposity indices. In contrast, in adolescents whose fat intake was between 30% and 35% of energy (N = 190), the rs9939609 polymorphism was associated with a 1.9% higher body fat per risk allele (95%CI: 0.39, 3.33; P < 0.05), and in those whose fat intake was higher than 35% (N = 259), it was associated with a 2.8% higher body fat per risk allele (95%CI: 1.27, 4.43; P < 0.001). Conclusions These findings support the concept that the deleterious effect of the FTOrs9939609 polymorphism on adiposity is exacerbated in adolescents consuming high fat diets. In contrast, the consumption of low fat diets (

Published
2018

20. Social vulnerabilities as determinants of overweight in 2-, 4-and 6-year-old Spanish children

Author

Iguacel, I., Fernandez-Alvira, J.M., Labayen, I., Moreno, L.A., Samper, M.P., and Rodriguez, G.

Abstract

Background: Differences in obesity prevalence among vulnerable groups exist in childhood but it remains unclear whether these differences may be partly determined by socioeconomic status (SES), parental body mass index (BMI) and early life risk factors. We aimed to explore (i) longitudinal associations between belonging to a minority group and being overweight/obese at age 2, 4 and 6 and (ii) associations between accumulation of social vulnerabilities and being overweight/obese at age 6. Methods: In total, 1031 children (53.8% boys) were evaluated at birth and re-examined during a 6-year follow-up in a representative cohort of Aragon (Spain). Children from minority (vulnerable) groups included Spanish Roma/gypsies, Eastern Europeans, Latin Americans and Africans. Two more vulnerable groups were defined at baseline as children whose parents reported low occupation and education. Ethnicity, SES and parental BMI were collected via interviews. We used logistic mixed-effects models and adjusted for parental BMI, SES, mother''s tobacco use, maternal weight gain, birth weight, infant weight gain and breastfeeding practices. Results: Regardless of confounders, Roma/gypsy children (OR = 4.63;[1.69-12.70]95% CI) and with Latin American background (OR = 3.04;[1.59-5.82]95% CI) were more likely to be overweight/obese at age 6 compared with non-gypsy Spanish group. Children with three vulnerabilities (OR = 2.18;[1.31-3.64]95% CI) were more likely to be overweight/obese at age 6 compared with children with no vulnerabilities. No associations were found between belonging to a minority group and overweight/obesity in children under 6. Conclusion: Interventions should target Roma/gypsy children, Latin American children and those who accumulate more vulnerabilities as they are at higher risk of being overweight/obese at age 6.

Published
2018

24. Associations between macronutrient intake and serum lipid profile depend on body fat in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study

Author

Bel Serrat S, Mouratidou T, Huybrechts I, Labayen I, Cuenca García M, Palacios G, Breidenassel C, Molnár D, Roccaldo R, Widhalm K, Gottrand F, Kafatos A, Manios Y, Vyncke K, Sjöström M, Libuda L, Gómez Martínez S, Moreno LA, Moreno L, De Henauw S, González Gross M, Gilbert C, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús J, Rodríguez G, Tomás C, Mesana M, Vicente Rodríguez G, Villarroya A, Gil C, Ara I, Revenga J, Lachen C, Fernández Alvira J, Bueno G, Lázaro A, Bueno O, León J, Garagorri JM, Rey López J, Iglesia I, Velasco P, Gracia Marco L, Jiménez Pavón D, Marcos A, Wärnberg J, Nova E, Ligia Díaz E, Romeo J, Veses A, Angeles Puertollano M, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster M, Nagy E, Kovács O, Répasi J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Vardavas C, Sbokos M, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo M, Gutiérrez A, Ortega F, Ruiz J, Artero E, España V, Chillón P, Sánchez Muñoz C, Cuenca M, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Grammatikaki E, Bouloubasi Z, Louisa Cook T, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Hagströmer M, Hallström L, Patterson E, Kwak L, Rizzo N, Hurtig Wennlöf A, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres J, Merino G, Sanjuán R, Lorente M, Sánchez M, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Lilja Hallberg M, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito P, Cañada D, Urzanqui A, Ortiz J, Fuentes F, Gómez Lorente J, Mardía Torres R, Navarro P., VITAGLIONE, PAOLA, Bel Serrat, S, Mouratidou, T, Huybrechts, I, Labayen, I, Cuenca García, M, Palacios, G, Breidenassel, C, Molnár, D, Roccaldo, R, Widhalm, K, Gottrand, F, Kafatos, A, Manios, Y, Vyncke, K, Sjöström, M, Libuda, L, Gómez Martínez, S, Moreno, La, Moreno, L, De Henauw, S, González Gross, M, Gilbert, C, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, J, Rodríguez, G, Tomás, C, Mesana, M, Vicente Rodríguez, G, Villarroya, A, Gil, C, Ara, I, Revenga, J, Lachen, C, Fernández Alvira, J, Bueno, G, Lázaro, A, Bueno, O, León, J, Garagorri, Jm, Rey López, J, Iglesia, I, Velasco, P, Gracia Marco, L, Jiménez Pavón, D, Marcos, A, Wärnberg, J, Nova, E, Ligia Díaz, E, Romeo, J, Veses, A, Angeles Puertollano, M, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, M, Nagy, E, Kovács, O, Répasi, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Vardavas, C, Sbokos, M, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, M, Gutiérrez, A, Ortega, F, Ruiz, J, Artero, E, España, V, Chillón, P, Sánchez Muñoz, C, Cuenca, M, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Grammatikaki, E, Bouloubasi, Z, Louisa Cook, T, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Hagströmer, M, Hallström, L, Patterson, E, Kwak, L, Rizzo, N, Hurtig Wennlöf, A, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, J, Merino, G, Sanjuán, R, Lorente, M, Sánchez, M, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Lilja Hallberg, M, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, P, Cañada, D, Urzanqui, A, Ortiz, J, Fuentes, F, Gómez Lorente, J, Mardía Torres, R, and Navarro, P.

Subjects
Male, 030309 nutrition & dietetics, Saturated fat, macronutrient intake, serum lipids, Medicine (miscellaneous), Blood lipids, Adolescents, 0302 clinical medicine, 2. Zero hunger, 0303 health sciences, Nutrition and Dietetics, medicine.diagnostic_test, Diet Records, 3. Good health, Europe, Adipose Tissue, Body fat, Female, lipids (amino acids, peptides, and proteins), medicine.medical_specialty, Waist, Adolescent, Medicina, 030209 endocrinology & metabolism, 03 medical and health sciences, Macronutrient intake, Internal medicine, Total cholesterol, Dietary Carbohydrates, medicine, Humans, Serum lipids, Triglycerides, Carbohydrate intake, Deportes, Waist-Height Ratio, business.industry, Cholesterol, HDL, Feeding Behavior, Dietary Fats, Coronary heart disease, Diet, Maternal education, Cross-Sectional Studies, Endocrinology, Mental Recall, Energy Intake, Lipid profile, business, Demography
Abstract

© 2014 The Authors. The present study aimed to investigate the relationships between macronutrient intake and serum lipid profile in adolescents from eight European cities participating in the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) cross-sectional study (2006-7), and to assess the role of body fat-related variables in these associations. Weight, height, waist circumference, skinfold thicknesses, total cholesterol, HDL-cholesterol (HDL-C), LDL-cholesterol, TAG, apoB and apoA1 were measured in 454 adolescents (44 % boys) aged 12·5-17·5 years. Macronutrient intake (g/4180 kJ per d (1000 kcal per d)) was assessed using two non-consecutive 24 h dietary recalls. Associations were evaluated by multi-level analysis and adjusted for sex, age, maternal education, centre, sum of four skinfolds, moderate-to-vigorous physical activity, sedentary behaviours and diet quality index for adolescents. Carbohydrate intake was inversely associated with HDL-C (β =-0·189, P< 0·001). An inverse association was found between fat intake and TAG (β =-0·319, P< 0·001). Associations between macronutrient intake and serum lipids varied according to adiposity levels, i.e. an inverse association between carbohydrate intake and HDL-C was only observed in those adolescents with a higher waist:height ratio. As serum lipids and excess body fat are the major markers of CVD, these findings should be considered when developing strategies to prevent the risk of CVD among adolescents., TheHELENA study was financially supported by the European Community Sixth RTD Framework Programme (contract FOOD-CT-2005-007034).

Published
2014

25. Health inequalities in urban adolescents: role of physical activity, diet, and genetics

Author

Ortega FB, Ruiz JR, Labayen I, Martínez Gómez D, Vicente Rodriguez G, Cuenca García M, Gracia Marco L, Manios Y, Beghin L, Molnar D, Polito A, Widhalm K, Marcos A, González Gross M, Kafatos A, Breidenassel C, Moreno LA, Sjöström M, Castillo MJ, Gottrand F, De Henauw S, Gilbert C, Libersa C, Sáchez J, Kesting M, Sjostrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Mouratidou T, Wärnberg J, Nova E, Gómez S, Ligia Díaz E, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Iliescu C, Von Berlepsch J, Kersting M, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Nagy E, Kovács O, Repásy J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Gutiérrez Á, Artero EG, España Romero V, Jiménez Pavón D, Chillón P, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Huybrecht I, Phillipp K, Dietrich S, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Sjöstrom M, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Enrique Carreres J, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Lilja M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito PJ, Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P., VITAGLIONE, PAOLA, Ortega, Fb, Ruiz, Jr, Labayen, I, Martínez Gómez, D, Vicente Rodriguez, G, Cuenca García, M, Gracia Marco, L, Manios, Y, Beghin, L, Molnar, D, Polito, A, Widhalm, K, Marcos, A, González Gross, M, Kafatos, A, Breidenassel, C, Moreno, La, Sjöström, M, Castillo, Mj, Gottrand, F, De Henauw, S, Gilbert, C, Libersa, C, Sáchez, J, Kesting, M, Sjostrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Mouratidou, T, Wärnberg, J, Nova, E, Gómez, S, Ligia Díaz, E, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Iliescu, C, Von Berlepsch, J, Kersting, M, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Török, K, Bokor, S, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Gutiérrez, Á, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Huybrecht, I, Phillipp, K, Dietrich, S, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Sjöstrom, M, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Enrique Carreres, J, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Lilja, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Lorente, Jj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Torres, Rm, and Navarro, P.

Published
2014

26. Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study

Author

Ruiz JR, Labayen I, Ortega FB, Moreno LA, Rodriguez G, Breidenassel C, Manios Y, Kafatos A, Molnar D, De Henauw S, Gottrand F, Widhalm K, Castillo MJ, Sjöström M, González Gross M, Gilbert C, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez Martinez S, Díaz LE, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Repásy J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Gutiérrez Á, Artero EG, España Romero V, Jiménez Pavón D, Chillón P, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Le Donne C, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito PJ, Calderón J, Gómez Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P., VITAGLIONE, PAOLA, Ruiz, Jr, Labayen, I, Ortega, Fb, Moreno, La, Rodriguez, G, Breidenassel, C, Manios, Y, Kafatos, A, Molnar, D, De Henauw, S, Gottrand, F, Widhalm, K, Castillo, Mj, Sjöström, M, González Gross, M, Gilbert, C, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez Martinez, S, Díaz, Le, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Gutiérrez, Á, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Le Donne, C, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Calderón, J, Gómez Lorente, Jj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Torres, Rm, and Navarro, P.

Published
2014

28. Physical activity attenuates the negative effect of low birth weight on leptin levels in European adolescents; the HELENA study

Author

Labayen, I., Ortega, F. B., Moreno, L. A., Gonzalez Gross, M., Jimenez Pavon, D., Martínez Gómez, D., Breidenassel, C., Marcos, A., Molnar, D., Manios, Y., Plada, M., Kafatos, A., De Henauw, S., Mauro, B., Zaccaria, M., Widhalm, K., Gottrand, F., Castillo, M. J., Sjöström, M., Ruiz, J. R., Moreno LA, Gottrand F, De Henauw S, González Gross M, Gilbert C, Kafatos A, Libersa C, Sánchez J, Kersting M, Sjöstrom M, Molnár D, Dallongeville J, Hall G, Maes L, Scalfi L, Meléndez P, Fleta J, Casajús JA, Rodríguez G, Tomás C, Mesana MI, Vicente Rodríguez G, Villarroya A, Gil CM, Ara I, Revenga J, Lachen C, Alvira JF, Bueno G, Lázaro A, Bueno O, León JF, Garagorri JM, Bueno M, López JP, Iglesia I, Velasco P, Bel S, Marcos A, Wärnberg J, Nova E, Gómez Martinez S, Díaz LE, Romeo J, Veses A, Puertollano MA, Zapatera B, Pozo T, Beghin L, Iliescu C, Von Berlepsch J, Sichert Hellert W, Koeppen E, Molnar D, Erhardt E, Csernus K, Török K, Bokor S, Angster, Nagy E, Kovács O, Repásy J, Codrington C, Plada M, Papadaki A, Sarri K, Viskadourou A, Hatzis C, Kiriakakis M, Tsibinos G, Sbokos CV, Protoyeraki E, Fasoulaki M, Stehle P, Pietrzik K, Breidenassel C, Spinneker A, Al Tahan J, Segoviano M, Berchtold A, Bierschbach C, Blatzheim E, Schuch A, Pickert P, Castillo MJ, Gutiérrez Á, Ortega FB, Ruiz JR, Artero EG, España Romero V, Jiménez Pavón D, Chillón P, Arcella D, Azzini E, Barrison E, Bevilacqua N, Buonocore P, Catasta G, Censi L, Ciarapica D, D'Acapito P, Ferrari M, Galfo M, Donne CL, Leclercq C, Maiani G, Mauro B, Mistura L, Pasquali A, Piccinelli R, Polito A, Spada R, Sette S, Zaccaria M, Montagnese C, De Bourdeaudhuij I, De Vriendt T, Matthys C, Vereecken C, de Maeyer M, Ottevaere C, Widhalm K, Phillipp K, Dietrich S, Kubelka B, Boriss Riedl M, Manios Y, Grammatikaki E, Bouloubasi Z, Cook TL, Eleutheriou S, Consta O, Moschonis G, Katsaroli I, Kraniou G, Papoutsou S, Keke D, Petraki I, Bellou E, Tanagra S, Kallianoti K, Argyropoulou D, Kondaki K, Tsikrika S, Karaiskos C, Meirhaeghe A, Bergman P, Hagströmer M, Hallström L, Hallberg M, Poortvliet E, Rizzo N, Beckman L, Wennlöf AH, Patterson E, Kwak L, Cernerud L, Tillgren P, Sörensen S, Sánchez Molero J, Picó E, Navarro M, Viadel B, Carreres JE, Merino G, Sanjuán R, Lorente M, Sánchez MJ, Castelló S, Thomas S, Allchurch E, Burguess P, Astrom A, Sverkén A, Broberg A, Masson A, Lehoux C, Brabant P, Pate P, Fontaine L, Sebok A, Kuti T, Hegyi A, Maldonado C, Llorente A, García E, von Fircks H, Hallberg ML, Messerer M, Larsson M, Fredriksson H, Adamsson V, Börjesson I, Fernández L, Smillie L, Wills J, Valtueña J, Albers U, Pedrero R, Meléndez A, Benito PJ, Calderón J, Lorente JJ, Cañada D, Urzanqui A, Ortiz JC, Fuentes F, Torres RM, Navarro P., VITAGLIONE, PAOLA, Labayen, I., Ortega, F. B., Moreno, L. A., Gonzalez Gross, M., Jimenez Pavon, D., Martínez Gómez, D., Breidenassel, C., Marcos, A., Molnar, D., Manios, Y., Plada, M., Kafatos, A., De Henauw, S., Mauro, B., Zaccaria, M., Widhalm, K., Gottrand, F., Castillo, M. J., Sjöström, M., Ruiz, J. R., Moreno, La, Gottrand, F, De Henauw, S, González Gross, M, Gilbert, C, Kafatos, A, Libersa, C, Sánchez, J, Kersting, M, Sjöstrom, M, Molnár, D, Dallongeville, J, Hall, G, Maes, L, Scalfi, L, Meléndez, P, Fleta, J, Casajús, Ja, Rodríguez, G, Tomás, C, Mesana, Mi, Vicente Rodríguez, G, Villarroya, A, Gil, Cm, Ara, I, Revenga, J, Lachen, C, Alvira, Jf, Bueno, G, Lázaro, A, Bueno, O, León, Jf, Garagorri, Jm, Bueno, M, López, Jp, Iglesia, I, Velasco, P, Bel, S, Marcos, A, Wärnberg, J, Nova, E, Gómez Martinez, S, Díaz, Le, Romeo, J, Veses, A, Puertollano, Ma, Zapatera, B, Pozo, T, Beghin, L, Iliescu, C, Von Berlepsch, J, Sichert Hellert, W, Koeppen, E, Molnar, D, Erhardt, E, Csernus, K, Török, K, Bokor, S, Angster, Nagy, E, Kovács, O, Repásy, J, Codrington, C, Plada, M, Papadaki, A, Sarri, K, Viskadourou, A, Hatzis, C, Kiriakakis, M, Tsibinos, G, Sbokos, Cv, Protoyeraki, E, Fasoulaki, M, Stehle, P, Pietrzik, K, Breidenassel, C, Spinneker, A, Al Tahan, J, Segoviano, M, Berchtold, A, Bierschbach, C, Blatzheim, E, Schuch, A, Pickert, P, Castillo, Mj, Gutiérrez, Á, Ortega, Fb, Ruiz, Jr, Artero, Eg, España Romero, V, Jiménez Pavón, D, Chillón, P, Arcella, D, Azzini, E, Barrison, E, Bevilacqua, N, Buonocore, P, Catasta, G, Censi, L, Ciarapica, D, D'Acapito, P, Ferrari, M, Galfo, M, Donne, Cl, Leclercq, C, Maiani, G, Mauro, B, Mistura, L, Pasquali, A, Piccinelli, R, Polito, A, Spada, R, Sette, S, Zaccaria, M, Vitaglione, Paola, Montagnese, C, De Bourdeaudhuij, I, De Vriendt, T, Matthys, C, Vereecken, C, de Maeyer, M, Ottevaere, C, Widhalm, K, Phillipp, K, Dietrich, S, Kubelka, B, Boriss Riedl, M, Manios, Y, Grammatikaki, E, Bouloubasi, Z, Cook, Tl, Eleutheriou, S, Consta, O, Moschonis, G, Katsaroli, I, Kraniou, G, Papoutsou, S, Keke, D, Petraki, I, Bellou, E, Tanagra, S, Kallianoti, K, Argyropoulou, D, Kondaki, K, Tsikrika, S, Karaiskos, C, Meirhaeghe, A, Bergman, P, Hagströmer, M, Hallström, L, Hallberg, M, Poortvliet, E, Rizzo, N, Beckman, L, Wennlöf, Ah, Patterson, E, Kwak, L, Cernerud, L, Tillgren, P, Sörensen, S, Sánchez Molero, J, Picó, E, Navarro, M, Viadel, B, Carreres, Je, Merino, G, Sanjuán, R, Lorente, M, Sánchez, Mj, Castelló, S, Thomas, S, Allchurch, E, Burguess, P, Astrom, A, Sverkén, A, Broberg, A, Masson, A, Lehoux, C, Brabant, P, Pate, P, Fontaine, L, Sebok, A, Kuti, T, Hegyi, A, Maldonado, C, Llorente, A, García, E, von Fircks, H, Hallberg, Ml, Messerer, M, Larsson, M, Fredriksson, H, Adamsson, V, Börjesson, I, Fernández, L, Smillie, L, Wills, J, Valtueña, J, Albers, U, Pedrero, R, Meléndez, A, Benito, Pj, Calderón, J, Lorente, Jj, Cañada, D, Urzanqui, A, Ortiz, Jc, Fuentes, F, Torres, Rm, and Navarro, P.

Subjects
Leptin, Male, medicine.medical_specialty, Time Factors, Time Factor, Adolescent, Birth weight, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, Physical activity, Medicine (miscellaneous), Gestational Age, Sex Factor, Motor Activity, Sex Factors, Internal medicine, medicine, Nutrition and Dietetic, Insulin, Humans, Nutrition and Dietetics, business.industry, Infant, Newborn, Gestational age, Actigraphy, Infant, Low Birth Weight, Europe, Low birth weight, Endocrinology, Linear Models, Gestation, Linear Model, Female, medicine.symptom, business, Cardiology and Cardiovascular Medicine, Human
Abstract

We examined whether physical activity (PA) influences the association between birth weight and serum leptin in adolescents. The study comprised a total of 538 adolescents (315 girls), aged 12.5-17.49 years, born at term (≥ 37 weeks of gestation). We measured serum leptin levels and time engaged in moderate-vigorous PA (MVPA) by accelerometry. There was an interaction effect between birth weight and meeting the PA recommendations (60 min/day MVPA) on leptin levels in girls (P = 0.023) but not in boys (P = 0.809). Birth weight was negatively associated with leptin levels in girls not meeting the PA recommendations (i.e. more than 60 min/day of MVPA) (β = -0.096, P = 0.009), whereas no significant association was observed in those meeting the PA recommendations (β = -0.061, P = 0.433). In conclusion, meeting the PA recommendations may attenuate the negative effect of low birth weight on serum leptin levels in European female adolescents.

Published
2011

29. Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: The HELENA cross-sectional study

Author

Labayen, I., primary, Ruiz, J.R., additional, Huybrechts, I., additional, Ortega, F.B., additional, Arenaza, L., additional, González-Gross, M., additional, Widhalm, K., additional, Molnar, D., additional, Manios, Y., additional, DeHenauw, S., additional, Meirhaeghe, A., additional, and Moreno, L.A., additional

Published
2016
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30. The effect of a multidisciplinary intervention program on hepatic adiposity in overweight-obese children: protocol of the EFIGRO study

Author

Medrano, M., primary, Maiz, E., additional, Maldonado-Martín, S., additional, Arenaza, L., additional, Rodríguez-Vigil, B., additional, Ortega, F.B., additional, Ruiz, J.R., additional, Larrarte, E., additional, Diez-López, I., additional, Sarasúa-Miranda, A., additional, Tobalina, I., additional, Barrenechea, L., additional, Pérez-Asenjo, J., additional, Kannengiesser, S., additional, Manhães-Savio, A., additional, Echaniz, O., additional, and Labayen, I., additional

Published
2015
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31. Correlates of ideal cardiovascular health in European adolescents: The HELENA study.

Author

Henriksson, P., Henriksson, H., Labayen, I., Huybrechts, I., Gracia-Marco, L., Ortega, F.B., España-Romero, V., Manios, Y., González-Gross, M., Marcos, A., Moreno, L.A., Gutiérrez, Á., Ruiz, J.R., and HELENA Study Group

Abstract

Background and Aims: The ideal cardiovascular health (iCVH) construct consists of 4 health behaviors (smoking status, body mass index, physical activity and diet) and 3 health factors (total cholesterol, blood pressure and fasting glucose). A greater number of iCVH components in adolescence are related to better cardiovascular health, but little is known about the correlates of iCVH in adolescents. Thus, the aim of the study was to examine correlates of iCVH in European adolescents.Methods and Results: The study comprised 637 European adolescents with complete iCVH data. Participants were part of the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, a cross-sectional, multicenter study conducted in 9 different European countries. Correlates investigated were sex and age, family affluence scale, maternal education, geographic location, sleep time, television viewing, duration of pregnancy, birth weight and breastfeeding. Younger adolescents, those whose mothers had medium/high education or those who watched television less than 2 h per day had a greater number of iCVH components compared to those who were older, had a mother with low education or watched television 2 h or more daily (P ≤ 0.01).Conclusion: Since in our study older adolescents had worse iCVH than younger adolescents, early promotion of cardiovascular health may be important. Future studies may also investigate the usefulness of limiting television viewing to promote iCVH. Finally, since adolescents of mothers with low education had poorer iCVH, it may be of special interest to tailor public health promotion to adolescents from families with low socioeconomic status. [ABSTRACT FROM AUTHOR]

Published
2018
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32. Central adiposity in children born small and large for gestational age

Author

Biosca, M., Rodríguez, G., Ventura, P., Samper, Mª P., Labayen, I., Collado, Mª P., Valle, S., Bueno, O., Santabárbara, J., and Moreno, L. A.

Subjects
Bone mineral content, Birth weight, Body fat, Contenido mineral óseo, Grasa corporal, Peso al nacer, Composición corporal, Body composition, female genital diseases and pregnancy complications, reproductive and urinary physiology
Abstract

Objective: To evaluate body composition differences between children that were born small (SGA) or large for gestational age (LGA) compared with their counterparts born adequate for gestational age (AGA). Methods: Body composition was assessed in 124 healthy Caucasian children (50% girls) aged 6-10, classified according to their birth weight for gestational age as AGA, SGA and LGA. Fat mass (FM), percentage of FM, lean mass (LM), bone mineral content (BMC) and bone mineral density were measured by dual-energy X-ray absorptiometry (DXA) in the whole body and at different body regions. Results: LM (adjusted for age and sex) and total BMC (adjusted for age, sex and weight) were both significantly higher in LGA children and lower in SGA when compared with those born AGA. After adjustments for height, LM and BMC differences between groups were not significant. In SGA children, truncal (P < 0.05) and abdominal fatness (P < 0.01) were higher when compared with both AGA and LGA children, after adjustments for age, sex and height. There were no differences in the percentage of total and central FM between children born LGA and AGA. Conclusions: During childhood, children born SGA had higher central adiposity regardless of their body size. Children born LGA seem to have a higher body size but with harmonic body composition and adequate body fat distribution. Small size for gestational age at birth could programme excess abdominal fat deposition in children, which is a major factor for the clustering of cardiovascular disease risk factors defining the metabolic syndrome. Objetivo: Evaluar las diferencias que existen en la composición corporal de aquellos niños que nacieron pequeños (PEG) o grandes para su edad gestacional (GEG) en comparación con los que presentaban un peso adecuado al nacer (AEG). Métodos: La composición corporal se valoró en 124 niños caucásicos (50% niñas) con edades entre 6 y 10 años, clasificados según su peso al nacer como AEG, PEG y GEG. La masa grasa (MG), el porcentaje de MG, la masa magra (MM), el contenido mineral óseo (CMO) y la densidad mineral ósea se midieron mediante absorciometría dual de rayos X (DXA) tanto globalmente como en las diferentes regiones corporales. Resultados: La MM (ajustada por edad y sexo) y el CMO (ajustado por edad, sexo y peso) fueron mayores en los GEG y menores en los PEG al compararlos con los AEG; al ajustar la MM el CMO por la altura, dichas diferencias ya no fueron significativas. En los PEG, la grasa abdominal (p < 0,01) y en el tronco (p < 0,05) eran mayores que en los AEG y que en los GEG tras ajustar por edad, sexo y altura. No existían diferencias en el porcentaje de MG total corporal y en porcentaje de grasa central entre los niños nacidos GEG y AEG. Conclusiones: Durante la infancia, los niños que nacieron PEG tenían mayor adiposidad central independientemente de su tamaño corporal. Los nacidos GEG seguían siendo grandes pero con una distribución armónica de la composición corporal y una adecuada distribución de la grasa corporal. Nacer con poco peso puede programar la grasa abdominal durante la infancia, cuyo aumento constituye uno de los factores de riesgo cardiovascular que definen el síndrome metabólico.

Published
2011

33. Attenuation of the Effect of the MTHFR and NOS3 Polymorphism on Blood Pressure by Physical Activity in European Adolescents. The HELENA Study.

Author

de Moraes, A. C. F., primary, Fernandez-Alvira, J. M., additional, Carvalho, H. B., additional, Meirhaeghe-Hurez, A., additional, Dallongeville, J., additional, Kafatos, A., additional, Molnar, D., additional, Manios, Y., additional, Labayen, I., additional, Ruiz, J. R., additional, Widhalm, K., additional, Breidenassel, C., additional, Gonzalez-Gross, M., additional, and Moreno, L. A., additional

Published
2015
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34. PP.16.24

Author

Maldonado-Martin, S., primary, Jurio-Iriarte, B., additional, Labayen, I., additional, Gorostegi-Anduaga, I., additional, Illera-Villas, M., additional, Medrano-Echeverria, M., additional, and Pérez-Asenjo, J., additional

Published
2015
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35. A Mediterranean diet is not enough for cardio-metabolic health: Physical activity and physical fitness are major contributors in European adolescent

Author

Cuenca-García, M., primary, Ruiz, J.R., additional, Ortega, F.B., additional, Labayen, I., additional, Huybrechts, I., additional, Moreno, L., additional, Libuda, L., additional, González-Gross, M., additional, Valtueña, J., additional, Santaliestra-Pasías, A., additional, Marcos, A., additional, Gómez-Martínez, S., additional, De Henauw, S., additional, and Castillo, M.J., additional

Published
2015
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37. Birth weight and blood lipid levels in Spanish adolescents: Influence of selected APOE, APOC3 and PPARgamma2 gene polymorphisms. The AVENA Study

Author

Ruiz, J.R. (Jonatan R.), Labayen, I. (Idoya), Ortega, F.B. (Francisco B.), Moreno, L.A. (Luis A.), Gonzalez-Lamuño, D. (Domingo), Marti, A. (Amelia), Nova, E. (Esther), Garcia-Fuentes, M. (Miguel), Redondo-Figuero, C. (Carlos), Martinez, J.A. (José Alfredo), Sjöström, M. (Michael), Castillo, M.J. (Manuel J.), AVENA Study Group, Ruiz, J.R. (Jonatan R.), Labayen, I. (Idoya), Ortega, F.B. (Francisco B.), Moreno, L.A. (Luis A.), Gonzalez-Lamuño, D. (Domingo), Marti, A. (Amelia), Nova, E. (Esther), Garcia-Fuentes, M. (Miguel), Redondo-Figuero, C. (Carlos), Martinez, J.A. (José Alfredo), Sjöström, M. (Michael), Castillo, M.J. (Manuel J.), and AVENA Study Group

Abstract

Background: There is increasing evidence indicating that genes involved in certain metabolic processes of cardiovascular diseases may be of particular influence in people with low body weight at birth. We examined whether the apolipoprotein (APO) E, APOC3 and the peroxisome proliferator-activated receptor-gamma-2 (PPAR gamma 2) polymorphisms influence the association between low birth weight and blood lipid levels in healthy adolescents aged 13-18.5 years. Methods: A cross-sectional study of 502 Spanish adolescents born at term was conducted. Total (TC) and high density lipoprotein cholesterol (HDLc), triglycerides (TG), apolipoprotein (apo) A and B, and lipoprotein(a) [ Lp(a)] were measured. Low density lipoprotein cholesterol (LDLc), TC-HDLc, TC/HDLc and apoB/apoA were calculated. Results: Low birth weight was associated with higher levels of TC, LDLc, apoB, Lp(a), TC-HDLc, TC/HDLc and apoB/apoA in males with the APOE epsilon 3 epsilon 4 genotype, whereas in females, it was associated with lower HDLc and higher TG levels. In males with the APOC3 S1/S2 genotype, low birth weight was associated with lower apoA and higher Lp(a), yet this association was not observed in females. There were no associations between low birth weight and blood lipids in any of the PPAR gamma 2 genotypes. Conclusion: The results indicate that low birth weight has a deleterious influence on lipid profile particularly in adolescents with the APOE epsilon 3/epsilon 4 genotype. These findings suggest that intrauterine environment interact with the genetic background affecting the lipid profile in later life.

Published
2014

38. Liver enzymes and clustering cardiometabolic risk factors in European adolescents: the HELENA study

Author

Labayen, I., primary, Ruiz, J. R., additional, Ortega, F. B., additional, Davis, C. L., additional, Rodríguez, G., additional, González‐Gross, M., additional, Breidenassel, C., additional, Dallongeville, J., additional, Marcos, A., additional, Widhalm, K., additional, Kafatos, A., additional, Molnar, D., additional, DeHenauw, S., additional, Gottrand, F., additional, and Moreno, L. A., additional

Published
2014
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40. Role of socio-cultural factors on changes in fitness and adiposity in youth : A 6-year follow-up study

Author

Ortega, F. B., Ruiz, J. R., Labayen, I., Hurtig-Wennlof, Anita, Harro, J., Kwak, L., Oja, L., Merenakk, L., Veidebaum, T., Sjostrom, M., Ortega, F. B., Ruiz, J. R., Labayen, I., Hurtig-Wennlof, Anita, Harro, J., Kwak, L., Oja, L., Merenakk, L., Veidebaum, T., and Sjostrom, M.

Abstract

BACKGROUND AND AIMS: Optimal cardio-respiratory fitness and adiposity levels are tightly related to health in youth. We analysed changes in fitness and adiposity in young individuals from two countries, and examined the role of maternal education in these changes. METHODS AND RESULTS: A 6-year follow-up study was conducted on 483 Estonian children (9 years) and 466 Swedish children (9-10 years) and adolescents (15 years). Fitness was assessed by a maximal bike test, and total and central adiposity were indirectly estimated by skinfolds (Slaughter's equation for fat mass) and waist circumference. At follow-up, fitness and adiposity had increased in the children cohort (P ≤ 0.001), while small or no change occurred in the adolescent cohort. In the children cohort, Estonian participants had a lower increase in fitness and a higher increase in adiposity (total and central) than Swedish participants. Higher maternal education increased the odds of remaining fit (top quartile) by half and reduced the risk of remaining fat (top quartile) by half; odds ratios = 1.56 (1.00-2.43), 0.50 (0.32-0.77) and 0.61 (0.39-0.94) for fitness, total and central adiposity, respectively. CONCLUSIONS: Our data suggest that the socioeconomic situation of a country might influence key cardiovascular risk factors (fitness and adiposity), being at higher risk for a low-middle income country (Estonia) than a higher income country (Sweden). The findings stress the role of socioeconomic status, particularly maternal education, in the maintenance of healthy fitness and adiposity levels from childhood into later life. Preventive efforts have to be taken from early age.

Published
2013
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41. Objectively Measured Physical Activity and Sedentary Time during Childhood, Adolescence and Young Adulthood: A Cohort Study

Author

Ortega, F, Konstabel, K, Pasquali, E, Ruiz, J, Hurtig Wennlöf, A, Mäestu, J, Löf, M, Harro, J, Bellocco, R, Labayen, I, Veidebaum, T, Sjöström, M, Sjöström, M., BELLOCCO, RINO, Ortega, F, Konstabel, K, Pasquali, E, Ruiz, J, Hurtig Wennlöf, A, Mäestu, J, Löf, M, Harro, J, Bellocco, R, Labayen, I, Veidebaum, T, Sjöström, M, Sjöström, M., and BELLOCCO, RINO

Abstract

Background:To know how moderate-to-vigorous physical activity (MVPA) and sedentary time change across lifespan periods is needed for designing successful lifestyle interventions. We aimed to study changes in objectively measured (accelerometry) MVPA and sedentary time from childhood to adolescence and from adolescence to young adulthood.Methods:Estonian and Swedish participants from the European Youth Heart Study aged 9 and 15 years at baseline (N = 2312) were asked to participate in a second examination 6 (Sweden) to 9/10 (Estonia) years later. 1800 participants with valid accelerometer data were analyzed.Results:MVPA decreased from childhood to adolescence (-1 to -2.5 min/d per year of follow-up, P = 0.01 and <0.001, for girls and boys respectively) and also from adolescence to young adulthood (-0.8 to -2.2 min/d per year, P = 0.02 and <0.001 for girls and boys, respectively). Sedentary time increased from childhood to adolescence (+15 and +20 min/d per year, for girls and boys respectively, P<0.001), with no substantial change from adolescence to young adulthood. Changes in both MVPA and sedentary time were greater in Swedish than in Estonian participants and in boys than in girls. The magnitude of the change observed in sedentary time was 3-6 time larger than the change observed in MVPA.Conclusions:The decline in MVPA (overall change = 30 min/d) and increase sedentary time (overall change = 2:45 h/d) observed from childhood to adolescence are of concern and might increase the risk of developing obesity and other chronic diseases later in life. These findings substantially contribute to understand how key health-related behaviors (physical activity and sedentary) change across important periods of life. © 2013 Ortega et al.

Published
2013

43. Physical activity attenuates the negative effect of low birth weight on leptin levels in European adolescents; The HELENA study

Author

Labayen, I., primary, Ortega, F.B., additional, Moreno, L.A., additional, Gonzalez-Gross, M., additional, Jimenez-Pavon, D., additional, Martínez-Gómez, D., additional, Breidenassel, C., additional, Marcos, A., additional, Molnar, D., additional, Manios, Y., additional, Plada, M., additional, Kafatos, A., additional, De Henauw, S., additional, Mauro, B., additional, Zaccaria, M., additional, Widhalm, K., additional, Gottrand, F., additional, Castillo, M.J., additional, Sjöström, M., additional, and Ruiz, J.R., additional

Published
2013
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47. Association between the FTO rs9939609 polymorphism and leptin in European adolescents: a possible link with energy balance control. The HELENA study

Author

Labayen, I, primary, Ruiz, J R, additional, Ortega, F B, additional, Dalongeville, J, additional, Jiménez-Pavón, D, additional, Castillo, M J, additional, De Henauw, S, additional, González-Gross, M, additional, Bueno, G, additional, Molnar, D, additional, Kafatos, A, additional, Díaz, L E, additional, Meirhaeghe, A, additional, and Moreno, L A, additional

Published
2010
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49. Determinants of birth size in Northeast Spain.

Author

Escartín, L., Samper, M. P., Santabárbara, J., Labayen, I., Álvarez, M. L., Ayerza, A., Oves, B., Moreno, L. A., and Rodríguez, G.

Subjects
GESTATIONAL age, WEIGHT gain in pregnancy, NEWBORN infants, PREGNANT women, ANTHROPOMETRY, REGRESSION analysis
Abstract

Objective: To update knowledge on determinants of newborn body size in Northeast of Spain considering gestational, parental and socio-cultural variables. Methods: Cross-sectional assessment of 1442 infants from Aragón (Spain), born at term between March 2009 and March 2010. Obstetric, neonatal, socio-demographic and parental anthropometry data were collected during the first infant scheduled health examination. Hierarchical linear regression models were used to explore associations between newborn anthropometry and included variables. Results: Birth weight was significantly higher in males than in females (130.7 g), when mother did not smoke during pregnancy (126.3 g), in immigrant mothers (113.1 g) and when parity increased (67.1 g per additional birth). Body weight at birth was 16.9 g higher per kg of maternal weight gain during pregnancy, 5.4 g higher per kg of maternal pre-pregnancy weight and 5.1 g higher per cm of maternal height. Birth length was also significantly higher in males than in females (0.87 cm), when mother did not smoke (0.48 cm), in immigrant mothers (0.64 cm), and it was positively associated with parity, maternal anthropometry and paternal height. Newborn anthropometry was not associated with maternal age, educational level or living location. Conclusions: Independently of gestational age and newborn sex, the main predictors of birth weight and length were maternal pre-pregnancy anthropometry and weight gain during gestation, to smoke during pregnancy, parity and maternal origin. Our results identify potential modifiable factors influencing newborn body size. [ABSTRACT FROM AUTHOR]

Published
2014
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