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1. Health and wellbeing status of the long-lived individuals of the Spanish LONGECYL cross-sectional study

Author

Vega-Alonso, Tomás, Lozano-Alonso, José, Estévez-Iglesias, Lorena, Ordax-Díez, Ana, Arrieta-Antón, Enrique, Díaz-Rodríguez, Ángel, Yañez-Ortega, José-Luis, Santos-Lozano, Alejandro, Nuñez-Torres, Rocío, Perez-Caro, María, Pita, Gillermo, Pinto-Labajo, Rosa, Alonso Ramos, María-Jesús, Álamo-Sanz, Rufino, García-Montero, Andrés-C, and Gonzalez-Neira, Anna

Published
2024
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4. Health and wellbeing status of the long-lived individuals of the Spanish LONGECYL cross-sectional study

Author

Tomás Vega-Alonso, José Lozano-Alonso, Lorena Estévez-Iglesias, Ana Ordax-Díez, Enrique Arrieta-Antón, Ángel Díaz-Rodríguez, José-Luis Yañez-Ortega, Alejandro Santos-Lozano, Rocío Nuñez-Torres, María Perez-Caro, Gillermo Pita, Rosa Pinto-Labajo, María-Jesús Alonso Ramos, Rufino Álamo-Sanz, Andrés-C García-Montero, and Anna Gonzalez-Neira

Subjects
Longevity, Health status, Quality of life, Activities of Daily Living, Spain, Public aspects of medicine, RA1-1270
Abstract

Abstract Background The increase in life expectancy and long-lived individuals is a challenge for public health and provides an opportunity to understand the determinants of longevity. However, few studies have addressed the factors associated with the health status and quality of life in a long-lived individual population. We described the perceived health, clinical status, quality of life, and dependency for activities of daily living in a representative population in Castile and Leon, Spain. Methods A sample of 759 long-lived individuals aged 95 years and older was studied by the Health Sentinel Network of Castile and Leon (Spain) through a health examination and a structured questionnaire covering quality of life (EQ-5D-3), lifestyle habits, diet, working life and family health. A blood sample was taken for the study of biological and genetic markers. Chi Square and logistic regression OR with 95% confidence intervals were used to analyze the determinants of the long-lived individuals’ health status. The significant level for the bivariate analysis was established at 0.05. Results Perceived health was good, very good or excellent in 64.2%, while only 46.0% had a quality-of-life index above 0.5 (ranging from 0 to 1) and 44.1% maintained acceptable independence for activities of daily living. Quality-of-life index was higher in the oldest, (OR 7.98 [2,32-27.41]) above 100 years compared to those under 98, and men had better values for independence than women (OR 2.43 [1.40–4.29]). Cardiovascular diseases were the most prevalent (85.5%), but neurological and mental diseases and vision problems had the highest impact on quality of life and independence. Conclusion The long-lived individuals of Castile and Leon have a relatively well-preserved health status, although the perception of health is higher than that describing their quality of life and dependence. The quality of life was higher in the oldest age group and showed differences according to sex, with a better quality of life in men. Public health policies and programs should take in account the differences by sex and age as well as the prevention and control of the main conditions related with poor quality of life or dependence. Future research must include the interaction among genetic, socioeconomic, environmental, and other clinical factors in the quality of life and disability of long-lived individuals.

Published
2024
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6. Genre-Based Approach on Students’ Writing Performance in an Online Writing Instruction

Author

Labajo, Mark Daryl S., Casero-Ripollés, Andreu, Series Editor, Barredo Ibáñez, Daniel, Series Editor, Park, Han Woo, Series Editor, Khan, Intakhab Alam, Series Editor, Wekke, Ismail Suardi, Series Editor, Birkök, Mehmet Cüneyt, Series Editor, Striełkowski, Wadim, Series Editor, Handhika, Jeffry, editor, Lukitasari, Marheny, editor, Ricahyono, Sigit, editor, and Nugraha, Dewanta Arya, editor

Published
2024
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8. Infancias maléficas: la reconfiguración del canon fantástico a través del niño como tropo narrativo

Author

José María Galindo Pérez, Irune Labajo González, Sergio García Cabezas, and Alejandro Moreno Hernández

Subjects
Infancia, Canon fantástico, Análisis cultural, Humanidad, General Works
Abstract

Las figuras clásicas del canon fantástico han consolidado una serie de características fundamentales que las definen tanto desde lo estético como desde lo narrativo, pasando por lo ético. Esa aparente estabilidad se puede ver alterada cuando dichas figuras son presentadas bajo una forma infantil. El presente artículo quiere poner de manifiesto esa reconfiguración, a través de cuatro figuras emblemáticas de ese canon (el demonio, el licántropo, el monstruo de Frankenstein y el vampiro), y de sus correspondientes apariciones, de apariencia infantil, en un grupo de formas expresivas interesante por su variedad y pluralidad: un cómic manga, una serie de una plataforma de streaming, un videojuego y una película europea de terror.

Published
2024
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14. Family History in the Iberian Peninsula during Chalcolithic and Bronze Age: An Interpretation through the Genetic Analysis of Plural Burials

Author

Sara Palomo-Díez, Ángel Esparza-Arroyo, Cláudia Gomes, Olga Rickards, Elena Labajo-González, Bernardo Perea-Pérez, Cristina Martínez-Labarga, and Eduardo Arroyo-Pardo

Subjects
ancient DNA, kinship analysis, family, Iberian Peninsula, bioarchaeology, paleogenetics, Social Sciences
Abstract

Throughout history, it has been observed that human populations have buried the deceased members of their communities following different patterns. During the Copper Age and the Bronze Age—periods on which this study focuses—in the northern sub-plateau of the Iberian Peninsula, we identified different patterns of multiple or collective burial. This work analyzes a total of 58 individuals buried in different multiple or collective graves, to investigate whether the practice of these burials implies a family or biological link between individuals buried together. With this aim, STR markers of nuclear DNA were analyzed, as well as the hypervariable regions I and II of mitochondrial DNA, establishing both close kinship relationships and relationships through maternal lineage. We observed different burial patterns, detecting certain maternal lines preserved in some common burials maintained over time. Close family relationships were observed to a lesser extent, with some occasional exceptions. The results of the analysis formed the basis for a discussion on the concepts of family and community.

Published
2024
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15. Short-term outcomes of chemoradiotherapy and local excision versus total mesorectal excision in T2-T3ab,N0,M0 rectal cancer: a multicentre randomised, controlled, phase III trial (the TAU-TEM study)

Author

Serra-Aracil, X., Pericay, C., Badia-Closa, J., Golda, T., Biondo, S., Hernández, P., Targarona, E., Borda-Arrizabalaga, N., Reina, A., Delgado, S., Vallribera, F., Caro, A., Gallego-Plazas, J., Pascual, M., Álvarez-Laso, C., Guadalajara-Labajo, H.G., and Mora-Lopez, L.

Published
2023
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16. Effectiveness and safety of integrase strand transfer inhibitors in Spain: a prospective real-world study

Author

José Ramón Santos, Maria Casadellà, Marc Noguera-Julian, Rafael Micán-Rivera, Pere Domingo, Antonio Antela, Joaquin Portilla, Jesús Sanz, Marta Montero-Alonso, Jordi Navarro, Mar Masiá, Nieves Valcarce-Pardeiro, Antonio Ocampo, Laura Pérez-Martínez, Coral García-Vallecillos, María Jesús Vivancos, Arkaitz Imaz, José Antonio Iribarren, José Hernández-Quero, Judit Villar-García, Pilar Barrufet, Roger Paredes, INSTINCT study group, Mariona Perera, Anna Chamorro, Cristina Miranda, Nástor Sánchez, Anna Garcı́á, Núria Pérez, Juan González Garcı́á, María del Mar Gutiérrez, María Gracia Mateo, Elena Losada, Sergio Reus, Vicente Boix, Diego Torrús, Esperanza Merino, Angela Gutiérrez Liarte, Adrià Curran, Félix Gutiérrez, Anna Mariño Callejo, Alvarez Diaz Hortensia, Antonio Ocampo Hermida, Celia Miralles, Laura Labajo Leal, Guillermo Pousada, José Ramon Blanco, José Antonio Oteo, Ibarra Valvanera, Mercedes Sanz, Luis Metola, Juan Pascua, Daniel Podzamczer, Camila Piatti, Maialen Ibarguren, Laia Arbones, Marta Ruiz, Sara Cervanntes, Helena Pera, Jessica Toro, Nuria Perez-Alvarez, and Anna Garcia

Subjects
HIV, integrase strand transfer inhibitors (INSTI), real-world study, raltegravir, elvitegravir, dolutegravir, Microbiology, QR1-502
Abstract

IntroductionSecond-generation integrase strand transfer inhibitors (INSTIs) are preferred treatment options worldwide, and dolutegravir (DTG) is the treatment of choice in resource-limited settings. Nevertheless, in some resource-limited settings, these drugs are not always available. An analysis of the experience with the use of INSTIs in unselected adults living with HIV may be of help to make therapeutic decisions when second-generation INSTIs are not available. This study aimed to evaluate the real-life effectiveness and safety of dolutegravir (DTG), elvitegravir/cobicistat (EVG/c), and raltegravir (RAL) in a large Spanish cohort of HIV-1-infected patients.MethodsReal-world study of adults living with HIV who initiated integrase INSTIs DTG, EVG/c, and RAL-based regimens in three settings (ART-naïve patients, ART-switching, and ART-salvage patients). The primary endpoint was the median time to treatment discontinuation after INSTI-based regimen initiation. Proportion of patients experiencing virological failure (VF) (defined as two consecutive viral loads (VL) ≥200 copies/mL at 24 weeks or as a single determination of VL ≥1,000 copies/mL while receiving DTG, EVG/c or RAL, and at least 3 months after INSTI initiation) and time to VF were also evaluated.ResultsVirological effectiveness of EVG/c- and RAL-based regimens was similar to that of DTG when given as first-line and salvage therapy. Treatment switching for reasons other than virological failure was more frequent in subjects receiving EVG/c and, in particular, RAL. Naïve patients with CD4+ nadir

Published
2023
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18. Dentists’ Perceptions of Their SARS-CoV-2 Risk and Infection Control Needs

Author

Leonor Sánchez-Pérez, Dámaris Sosa de Antuñano, Bernardo Perea-Pérez, Elena Labajo-González, and A. Enrique Acosta-Gio

Subjects
Coronavirus, COVID-19, Dentists, Education, Infection control, Survey, Dentistry, RK1-715
Abstract

ABSTRACT: Objective: Rapid worldwide dissemination of SARS-CoV-2 has prompted dental professionals to optimise their infection control procedures. To help identify areas of opportunity for protecting dentists and their patients, the aim of this investigation was to analyse Mexican dentists’ early perceptions of their risk of exposure to SARS-CoV-2 and their need for comprehensive infection control education. Methods: This cross-sectional survey was conducted from May 9 to June 3, 2020, during the social distancing phase in Mexico. The survey adhered to relevant guidelines for ethical research design. The questionnaire was designed with Google Surveys and applied online in Spanish. The questionnaire included items on demographics and clinical specialisation. To obtain time-sensitive perceptions, statements were preceded by “While SARS-CoV-2 circulates in the community and new COVID-19 cases are reported”; responses were collected in a 5-point Likert-type scale. Results: The survey's link received 1524 “clicks.” Over 25 days, 996 dentists participated (39% men; 89% working in Mexico and 11% in other Spanish-speaking Latin American countries). Most participants (73%) fully agreed that “Looking after patients will pose a risk for the dentist.” Total agreement was more common (P = .0001) amongst dentists in Mexico (76%) than amongst those in other countries (53%). Knowing someone with COVID-19 was more common amongst Mexican dentists (P = .0008). The perceived need for enhanced infection control procedures increased with age (P = .0001). Forty-nine percent totally agreed that they sterilise dental handpieces between patients. One-third expressed total agreement that everyone in their clinic was trained in infection control. Conclusions: Amongst this nonprobabilistic self-selected sample of dentists, age and country of work influenced their perceptions about occupational exposure to SARS-CoV-2 and infection control needs. This survey revealed areas of opportunity to improve infection control education and training for dental professionals.

Published
2022
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19. Analyzing University Students’ Attitude and Behavior Toward AI Using the Extended Unified Theory of Acceptance and Use of Technology Model

Author

Obenza, Brandon Nacua, primary, Caballo, John Harry S, additional, Caangay, Ria Bianca R, additional, Makigod, Trisha Eunice C, additional, Almocera, Sharldawn M, additional, Bayno, John Lawrence M, additional, Camposano, Joseph Jr R, additional, Cena, Sandy Jean G, additional, Garcia, Judy Ann Kyll, additional, Labajo, Bea Faye M, additional, and Tua, Athena Grace, additional

Published
2024
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21. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study

Author

Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, Retamar, Pilar, Valiente, Adoración, López-Cortés, Luis E., Sojo-Dorado, Jesús, Bravo-Ferrer, José, Salamanca, Elena, Palacios-Baena, Zaira R., Pérez-Palacios, Patricia, Gandullo-Moro, María, Ruíz-Hueso, Rocío, Moya-González, Natalia, Valido-Morales, Agustín, Pavón-Masa, María, Díaz Menéndez, Marta, De la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, De Miguel Buckley, Rosa, Cadiñanos Loidi, Julen, Busca Arenzana, Carmen, Mican Rivera, Rafael, Mora Rillo, Marta, Loeches Yagüe, Belén, Bernardino de la Serna, José Ignacio, García Rodríguez, Julio, Montejano Sánchez, Rocío, Diaz Pollan, Beatriz, López, Juan Carlos, Ramírez-Schacke, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Parras, Francisco, Catalán, Pilar, García-Leoni, María E, Pérez-Tamayo, Isabel, Puente, Luis, Cedeño, Jamil, Such-Diaz, Ana, Álvaro-Alonso, Elena, Izquierdo-García, Elsa, Torres-Macho, Juan, Cuevas, Guillermo, Notario, Helena, Mestre-Gómez, Beatriz, Jiménez-González de Buitrago, Eva, Fernández-Jiménez, Inés, Tebar-Martínez, Ana Josefa, Brañas, Fátima, Valencia, Jorge, Pérez-Butragueño, Mario, Alvarado, Marta, Abelenda-Alonso, Gabriela, Ardanuy, Carmen, Bergas, Alba, Cuervo, Guillermo, Domínguez, María Ángeles, Fernández-Huerta, Miguel, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Pérez-Recio, Sandra, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Trullen, Núria, Cisneros, José Miguel, Amodeo, Cristina, Camacho, Pedro, Espinosa, Nuria, García-Gutiérrez, Manuel, Jara-Palomares, Luis, González-León, Rocío, Molina, José, Nieto Martín, María Dolores, Paniagua, María, Poyato, Manuel, Rodríguez-Villodres, Ángel, Ruiz de Azua, Zaida, Salamanca, Celia, Sepúlveda Berrocal, Mº Antonia, Yera Bergua, Carmen, Toledano Sierra, Pilar, Cano Llorente, Verónica, Zafar Iqubal-Mirza, Sadaf, Muñiz, Gema, Martín Pérez, Inmaculada, Mozas Moriñigo, Helena, Alguacil, Ana, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Goikoetxea Agirre, Josune, Blanco Vidal, María José, Nieto Arana, Javier, del Álamo Martínez de Lagos, Mikel, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Silvariño Fernández, Rafael, Ugalde Espiñeira, Jon, Rivas-Carmenado, María, Suárez Pérez, Lucia, Suárez Diaz, Silvia, Yllera Gutiérrez, Carmen, Boix, Vicente, Díez Martínez, Marcos, Carreres Candela, Melissa, Gómez-Ayerbe, Cristina, Sánchez-Lora, Javier, Velasco Garrido, José Luis, López-Jodar, María, Santos González, Jesús, Ruiz Aragón, Jesús, Virto Peña, Ianire, Alende Castro, Vanessa, Sande Llovo, Diana, Vega Molpeceres, Sonia, Pons Viñas, Estel, del Río Pérez, Oscar, Valero Rovira, Silvia, Villar-García, Judit, Gómez-Junyent, Joan, Cánepa, María Cecilia, Castañeda Espinosa, Silvia, Letang, Emilio, Arenas-Miras, María del Mar, Gómez-Zorrilla, Silvia, Sánchez Martínez, Francesca, Lerma-Chippirraz, Elisabet, García Vázquez, Elisa, Moral Escudero, Encarnación, Roura Piloto, Aychel Elena, García Almodóvar, Esther, Sáez Barberá, Carmen, Karroud, Zineb, Hernández Quero, José, Vinuesa García, David, García Fogeda, José Luis, Peregrina, José Antonio, Novella Mena, María, Hernández Gutiérrez, Cristina, Sanz Moreno, José, Pérez Tanoira, Ramón, Navarro López, Jorge, Balsa Vázquez, Javier, Gutiérrez García, Aida, Arranz Caso, Alberto, Cuadros González, Juan, Álvarez de Mon Soto, Melchor, Díaz De Brito Fernández, Vicente Ferrer, Sanmarti Vilamala, Montserrat, Gabarrell Pascuet, Aina, Molina Morant, Daniel, España Cueto, Sergio, Cámara Fernández, Jonathan, Sabater Gil, Albert, Muñoz López, Laura, Jorge García, Ruth, Molina Torres, Nora, Sempere Alcocer, Marco Antonio, De Castro Vega, Francisco Javier, De los Santos Gil, Ignacio, García-Fraile, Lucio, Sampedro Núñez, Miguel, Barrios Blandino, Ana, Rodríguez Franco, Carlos, Useros Brañas, Daniel, Villa Martí, Almudena, Oliver Ortega, Javier, Costanza Espiño Álvarez, Alexia, Sanz Sanz, Jesús, Rexach Fumaña, María, Policarpo Torres, Guillem, Ortega Montoliu, Meritxell, Sala Jofre, Clara, Casas Rodríguez, Susana, Tortajada Alamilla, Cecilia, Oltra, Carmina, Masiá Canuto, Mar, Gutiérrez Rodero, Félix, Oltra Sempere, María Rosa, Vela Berna, Sara, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, De la Vega, Alexandra, Pérez Pinto, Sergio, Hernández Machín, Pilar, Alastrué Violeta, Alba, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Gozalo, Mónica, Mora Gómez, Francisco, Milagro Beamonte, Ana, Latorre-Millán, Miriam, Rezusta López, Antonio, Martínez Sapiña, Ana, Meije, Yolanda, Ribera Puig, Alba, Ortega Enciso, Lucía, Sanz Salvador, Xavier, Losa García, Juan Emilio, Velasco Arribas, María, Pérez-Rodríguez, M. Teresa, Pérez González, Alexandre, Belhassen-García, Moncef, Rodríguez-Alonso, Beatriz, López-Bernus, Amparo, Carbonell, Cristina, Torres Perea, Rafael, Cantón De Seoane, Juan, Alonso, Blanca, Kamal, Sara Lidia, Cajuela, Lucía, Roa, David, Cervero, Miguel, Oreja, Alberto, Avilés, Juan Pablo, Martín, Lidia, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Abadia Otero, Jésica, Salillas Hernando, Juan, Torres Sánchez del Arco, Robert, Torralba González de Suso, Miguel, Serrano Martínez, Alberto, Gilaberte Reyzábal, Sergio, Pacheco Martínez-Atienza, Marina, Liébana Gómez, Mónica, Fernández Rodríguez, Sara, Varela Plaza, Álvaro, Calvo Sánchez, Henar, Martínez Martín, Patricia, González- Ruano, Patricia, Malmierca Corral, Eduardo, Rábago Lorite, Isabel, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Sirisi, Merce, Rojas, Richard, Díaz de Tuesta del Arco, José Luis, Figueroa Cerón, Ruth, González Sarria, Ander, Alemán Valls, Remedios, Alonso Socas, María del Mar, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Riera Jaume, Melchor, Vilchez, Helem Haydee, Albertí, Francesc, Cañabate, Ana Isabel, Moreno Cuerda, Víctor J, Álvarez Kaelis, Silvia, Álvarez Zapatero, Beatriz, García García, Alejandro, Isaba Ares, Elena, Morcate Fernández, Covadonga, Pérez Rodríguez, Andrea, Ramos Merino, Lucía, Castelo Corral, Laura, Rodríguez Mahía, María, González Bardanca, Mónica, Sánchez Vidal, Efrén, Míguez Rey, Enrique, Correa Ruiz, Ana, García de Lomas Guerrero, José Mº, Daniel López, Daniel, Marinas, Rebeca, Morando, Marta, Gómez García, Lucía, Boix Palop, Lucia, Dietl Gómez-Luengo, Beatriz, Pedrola Gorrea, Iris, Blasco Claramunt, Amparo, López Mestanza, Cristina, Fraile Villarejo, Esther, Jaén Sánchez, Nieves, Orihuela Martín, Jorge, Algado Rabasa, José Tomas, Garijo Saiz, Ana María, Amador Prous, Concepción, Salavert Lletí, Miguel, Hernández Belmonte, Adriana, Martínez Goñi, Raquel, Navarro Vilasaró, Marta, Calzado Isbert, Sonia, Cervantes García, Manuel, Gomila Grange, Aina, Gasch Blasi, Oriol, Machado Sicilia, María Luisa, Van den Eynde Otero, Eva, Falgueras López, Luis, Navarro Sáez, María del Carmen, Martínez, Esteban, Marcos, Mº Ángeles, Mosquera, Mar, Blanco, José Luis, Laguno, Montserrat, Rojas, Jhon, González-Cordón, Ana, Inciarte, Alexy, Torres, Berta, De la Mora, Lorena, Soriano, Alex, Martínez Macia, Olalla, Pérez Doñate, Virginia, Cabello Úbeda, Alfonso, Carrasco Antón, Nerea, Álvarez Álvarez, Beatriz, Petkova Saiz, Elizabet, Górgolas Hernández-Mora, Miguel, Prieto Pérez, Laura, Carrillo Acosta, Irene, Heili Frades, Sara, Villar Álvarez, Felipe, Fernández Roblas, Ricardo, Sánchez Pernaute, Olga, Fernández Espinilla, Virginia, Castrodeza Sanz, José Javier, Dueñas Gutiérrez, Carlos Jesús, González-Romo, Fernando, Merino Amador, Paloma, Rueda López, Alba, Martínez Jordán, Jorge, Medrano Pardo, Sara, Díaz de la Torre, Irene, Posada Franco, Yolanda, Delgado-Iribarren, Alberto, López-Contreras González, Joaquín, Pascual Alonso, Pablo, Pomar Solchaga, Virginia, Rabella García, Nuria, Benito Hernández, Natividad, Domingo Pedrol, Pere, Bonfill Cosp, Xavier, Padrós Selma, Rafael, Puig Campmany, Mireia, Mancebo Cortés, Jordi, Gurguí Ferrer, Mercè, Íñigo Pestaña, Melania, Pérez García, Alejandra, Sorní Moreno, Patricia, Izko Gartzia, Nora, Membrillo de Novales, Francisco Javier, Simón Sacristán, María, Zamora Cintas, Maribel, Martínez Martínez, Yolanda, Estébanez Muñoz, Miriam, Ramírez-Olivencia, Germán, Herrero Mendoza, María Dolores, De Dios García, Begoña, Mata Forte, Tatiana, Rodríguez Fernández, José María, Sáez de Adana Arróniz, Ester, Portu Zapirain, Joseba, Gainzarain Arana, Juan Carlos, Ortiz de Zárate Ibarra, Zuriñe, Moran Rodríguez, Miguel Ángel, Canut Blasco, Andrés, Hernáez Crespo, Silvia, Sanjosé Muñiz, Irene, Molina Iturritza, Estíbaliz, Ganchegui Aguirre, Maite, Urrestarazu Larrañag, Miren, De la Higuera Arranz, Carmen, Álvarez Padín, Pilar, Iglesias Llorente, Laura, Román Bernal, Berta, Sánchez Montalvá, Adrián, Espinosa Pereiro, Juan, Almirante, Benito, Miarons, Marta, Sellarés, Júlia, Larrosa, María, Villamarín, Miguel, Fernández, Nuria, Salvador, Fernando, Bosch-Nicolau, Pau, Pérez-Jorge Peremarch, Conchita, Resino Foz, Elena, Espigares Correa, Andrea, Álvarez de Espejo Montiel, Teresa, Navas Clemente, Iván, Quijano Contreras, María Isabel, Nieto Fernández del Campo, Luis Alberto, Jiménez Álvarez, Guillermo, Guillamón Sánchez, Mercedes, García García, Josefina, Muñoz Hornero, Constanza, Cosmen Sánchez, Ana, Mariño Callejo, Ana, Valcarce Pardeiro, Nieves, Smithson Amat, Alex, Chico Chumillas, Cristina, Sánchez Serrano, Adriana, Piñar Cabezos, Diana, Jiménez Martínez, Isabel, Estrada Fernández, Guillermo, Lorén Vargas, María, Parra Arribas, Nuria, Martínez Cilleros, Carmen, Villasante de la Puente, Aránzazu, García Delange, Teresa, Ruiz Rodríguez, María José, Robledo del Prado, Marta, Abad Almendro, Juan Carlos, Muñoz del Rey, José Román, Jiménez Álvaro, Montaña, Coy Coy, Javier, Poquet Catala, Inmaculada, Santos Peña, Marta, Mora Delgado, Juan, Manso Gómez, Tamara, Rubio Obanos, Teresa, Barbeito Castiñeiras, Gema, Domínguez Santalla, María Jesús, Mao Martín, Laura, Adalid Moll, María, Díaz Luperena, Javier, Ruiz Grinspan, Martín Sebastián, Barrós González, Raquel, Herrera Pacheco, Lourdes, Martínez Avilés, Rocío, Rodrigo González, Sara, Rodríguez Leal, Cristóbal Manuel, Romay Lema, Eva María, Suárez Gil, Roi, Bustinduy Odriozola, Maria Jesús, Marimón Ortiz de Zárate, José María, Vidaur Tello, Loreto, Kortajarena Urkola, Xabier, Arriola Martínez, Paula, Lartategi Iraurgi, Alazne, Álvarez de Castro, Maria, Martínez Mateu, Cintia María, Rodríguez Gómez, Francisco, Asschert Agüero, Isabel, Chamarro Martí, Elena, Franch Llasat, Diego, Zakariya-Yousef Breval, Ismail, Rico Rodríguez, Marta, Martínez López, Belén, García-López, María, Fernández Cruz, Ana, Calderón Parra, Jorge, Ramos Martínez, Antonio, Múñez Rubio, Elena, Vázquez Comendador, José Manuel, Diego Yagüe, Itziar, Expósito Palomo, Esther, Díaz de Santiago, Alberto, De la Fuente Moral, Sara, Pintos Pascual, Ilduara, Álvarez Franco, Raquel, Fernández de Orueta, Lucía, Vates Gómez, Roberto, Cardona Arias, Andrés Felipe, Marguenda Contreras, Pablo, Gaspar Alonso-Vega, Gabriel, Aranda Rife, Elena María, Martínez Cifre, Blanca, Roger Zapata, Daniel, Martín Rubio, Irene, Barbosa Ventura, André, Piñero, Iván, Bahamonde Carrasco, Alberto, Martínez Vidal, Ana, Talavera García, Eva, Mendoza Roy, Paula, Urrutia Losada, Ainhoa, Arteche Eguizabal, Lorea, Delgado Sánchez, Elisabet, Bañón Escandell, Sara, Caro Bragado, Sarah, Domínguez de Pablos, Gema, Herrero Rodríguez, Carmen, Liébana Martos, Carmen, Force Sanmartín, Luis, Aranega, Raquel, Mera Fidalgo, Arantzazu, Hortos Alsina, Miquel, Merchante Gutiérrez, Nicolas, León Jiménez, Eva María, Del Pozo, José L, Serralta Buades, Josefa, Cabrera Tejada, Ginger Giorgiana, Fernández-Ruiz, Mario, Aguado, José María, Maestro de la Calle, Guillermo, Vizcarra, Pilar, Rodriguez Dominguez, Mario José, Gioia, Francesca, Del Campo, Santos, Cantón Moreno, Rafael, Martín Dávila, Pilar, Casado, José Luis, Oteo Revuelta, José Antonio, Santibáñez Sáenz, Paula, Cervera Acedo, Cristina, Ruiz Martínez, Carlos, Blanco Ramos, José Ramón, Azcona Gutiérrez, José M., García García, Concepción, Alba Fernández, Jorge, Ibarra Cucalón, Valvanera, San Franco, Mercedes, Metola Sacristán, Luis, Meijide Míguez, Héctor, Gredilla Zubiría, Íñigo, Menéndez, Justo, Villares Fernández, Paula, Montes Andújar, Lara, Navarro Batet, Álvaro, Ferrer Santolaria, Anna, Padilla Salazar, María de la Luz, Abella Vázquez, Lucy, Hayek Peraza, Marcelino, García Pardo, Antonio, Hernández Carballo, Carolina, Ruiz Fernández, Andrés Javier, Barrio López, Isabel, Martakoush, Alí, Rojas-Vieyra, Agustín, García Calvo, Sonia, Villarreal García-Lomas, Mercedes, Vizcaíno Callejón, Marta, García García, María Pilar, Lérida Urteaga, Ana, Carrasco Fons, Natalia, María Sanjuan, Beatriz, Martín González, Lydia, Sanz Zamudio, Camilo, Alejos, Belén, Moreno, Cristina, Rava, Marta, Iniesta, Carlos, Izquierdo, Rebeca, Suárez-García, Inés, Díaz, Asunción, Ruiz-Alguero, Marta, Hernando, Victoria, Frías, Jesús, Ramírez, Elena, Martín-Quirós, Alejandro, Quintana-Díaz, Manuel, Mingorance, Jesús, Arnalich, Francisco, Moreno, Francisco, Figueiras, Juan Carlos, García-Arenzana, Nicolás, Montero-Vega, María Dolores, Romero-Gómez, María Pilar, Toro-Rueda, Carlos, García-Bujalance, Silvia, Ruiz-Carrascosa, Guillermo, Cendejas-Bueno, Emilio, Falces-Romero, Iker, Lázaro-Perona, Fernando, Ruiz-Bastián, Mario, Gutiérrez-Arroyo, Almudena, Girón De Velasco-Sada, Patricia, Dahdouh, Elie, Gómez-Arroyo, Bartolomé, García-Sánchez, Consuelo, Guedez-López, Virginia, Bloise-Sánchez, Iván, Alguacil-Guillén, Marina, Liras-Hernández, Maria Gracia, Sánchez-Castellano, Miguel Angel, García-Clemente, Paloma, González-Donapetry, Patricia, San José-Villar, S, de Pablos-Gómez, Manuela, Gómez-Gil, Rosa, Corcuera-Pindado, Maria Teresa, Rico-Nieto, Alicia, Herrero, Alicia, Prieto-Arribas, Daniel, Oliver-Saez, Paloma, Mora-Corcovado, Roberto, Fernández-Calle, Pilar, Alcaide-Martín, María José, Díaz-Garzón, Jorge, Fernández-Puntero, Belén, Nuñez-Cabetas, Rocío, Crespo-Sánchez, Gema, Rodriguez-Fraga, Olaia, Mendez del Sol, Helena, Duque-Alcorta, Marta, Gomez-Rioja, Rubén, Sanz de Pedro, María, Pascual-García, Lydia, Segovia-Amaro, Marta, Iturzaeta-Sánchez, Jose Manuel, Rodriguez-Gutiérrez, Mercedes, Perez-Garcia Morillón, Amparo, Martinez Gallego, Miguel Angel, Fabre-Estremera, Blanca, Martinez-Chavez, Estefanía, Moreno-Parra, Isabel, Rodriguez-Roca, Neila, Ortiz-Sánchez, Daniel, Simon-Velasco, Manuela, Gabriela-Tomoiu, Ileana, Pizarro-Sanchez, Cristina, Montero-San Martín, Blanca, Qasem-Moreno, Ana Laila, Gómez-López, Marta, Casares Guerrero, Ismael, Buño-Soto, Antonio, Martí de Gracia, Milagros, Parra-Gordo, Luz, Diez-Tascón, Aurea, Ossaba-Vélez, Silvia, Pinilla, Inmaculada, Cuesta, Emilio, Fernández-Velilla, María, Torres, Maria Isabel, Garzón, Gonzalo, Pérez-Blanco, Verónica, Quintás-Viqueira, Almudena, San Juan, Isabel, Cantero-Escribano, José Miguel, Pérez-Romero, César, Castro-Martínez, Mercedes, Hernández-Rivas, Lucía, Pedraz, Teresa, Fernández-Bretón, Eva, García-Vaz, Claudia, Robustillo-Rodela, Ana, Torres Santos-Olmo, Rosario María, Rivera-Núñez, Angélica, Fernández-Fernández, Ignacio, Noguerol-Gutiérrez, Marina, Martínez-Virto, Ana María, González-Viñolis, Manuel, Cabrera-Gamero, Regina, Mayayo-Alvira, Rosa, Marín-Baselga, Raquel, Lo-Iacono García, Victoria, Lerín-Baratas, Macarena, Romero Gallego-Acho, Paloma, Reche-Martínez, Begoña, Tejada-Sorados, Renzo, Rico-Briñas, Mikel, Deza-Palacios, Ricardo, Fabra-Cadenas, Sara, Arroyo-Rico, Isabel, Ben-Abdellah, Lubna Dani, Labajo-Montero, Laura, Soriano-Arroyo, Rubén, López-Corcuer, Lorena, Calvin-García, Elena, Martínez-Álvarez, Susana, López-Tappero Irazábal, Laura, Pilares-Barco, Martín, González-Peña, Olga, Bejarano-Redondo, Guillermina, Iglesias-Sigüenza, Alberto, Tung-Chen, Yale, Maroun Eid, Charbel, Bravo-Lizcano, Ruth, Silvestre-Niño, Miguel, Perdomo-García, Frank, Alonso-González, Berta, Antón-Huguet, Berta, Arenas-Berenguer, Isabel, Cabré-Verdiell Surribas, Clara, Marqués-González, Francisco, Muñoz del Val, Elena, Ángeles Molina, María, Cancelliere-Fernández, Nataly, Pastor-Yvorra, Sivia, Frade-Pardo, Laura, López-Arévalo, Paloma, García, Isabel, Fernández-Capitán, Carmen, González-Garcia, Juan José, Herrero, Juan, Quesada Simón, María Angustias, Robles Marhuenda, Angel, Soto Abanedes, Clara, Noblejas Mozo, Ana María, Ramos, Juan Carlos, Jaras Hernandez, María Jesús, Martinez Robles, Elena, Moreno Fernandez, Alberto, Sanchez Purificación, Aquilino, Martin Gutiérrez, Juan Carlos, Martinez Hernández, Pedro Luis, Sancho Bueso, Teresa, Lorenzo Hernández, Alicia, Gutierrez Sancerni, Belén, Salgueiro, Giorgina, Martin Carbonero, Luz, Mostaza, Jose María, Martinez-López, María Angeles, Hontañón, Victor, Menéndez, Araceli, Alvarez Troncoso, Jorge, Castellano, Arancha, Marcelo-Calvo, Cristina, Vives-Beltrán, Ivo, Ramos Ruperto, Luis, Daroca-Bengoa, Germán, Arcos Rueda, María, Vasquez-Manau, Julia, Fernández Cidón, Pelayo, Rosario Herrero Gil, Carmen, Palmier Peláez, Esmeralda, Untoria Tabares, Yeray, Lahoz, Carlos, Estirado, Eva, Hernández, Clara, Garcia-Iglesias, Francisca, Monteoliva, Enrique, Martínez, Mónica, Vara, Marta, González Alegre, Teresa, Valencia, Maria Eulalia, Moreno, Victoria, Montes, Maria Luisa, Alcolea-Batres, Sergio, Cabanillas-Martín, Juan José, Carpio-Segura, Carlos, Casitas-Mateo, Raquel, Fernández-Bujarrabal Villoslada, Jaime, Fernández-Navarro, Isabel, Fernández-Lahera, Juan, García-Quero, Cristina, Hidalgo-Sánchez, María, Galera-Martínez, Raúl, García-Río, Francisco, Gómez-Carrera, Luis, Gómez-Mendieta, María Antonia, Mangas-Moro, Alberto, Martínez-Cerón, Elisabet, Martínez-Redondo, María, Martínez-Abad, Yolanda, Martínez-Verdasco, Antonio, Plaza-Moreno, Cristina, Quirós-Fernández, Sarai, Romera-Cano, Delia, Romero-Ribate, David, Sánchez-Sánchez, Begoña, Santiago-Recuerda, Ana, Villasante, Carlos, Zamarrón de Lucas, Ester, Arnalich-Montiel, Victoria, Mariscal-Aguilar, Pablo, Falcone, Adalgisa, Laorden-Escudero, Daniel, Prados Sánchez, María Concepción, Álvarez-Sala Walther, Rodolfo, García, Andony, Arévalo, Cristina, Gutiérrez, Carola, Yus, Santiago, Asensio, Maria José, Sánchez, Manolo, Añón, Jose Manuel, Manzanares, Jesús, García de Lorenzo, Abelardo, Perales, Eva, Civantos, Belén, Cachafeiro, Lucía, Agrifoglio, Alexander, Estébanez, Belén, Flores, Eva, Hernández, Mónica, Millán, Pablo, Rodríguez, Montserrat, Nanwani, Kapil, Arizcun, Beatriz, Pérez-Costa, Elena, Rodríguez-Álvarez, Diego, Sánchez-Martín, María, Quesada, Úrsula, Román-Hernández, Carmen, Dorao, Paloma, Álvarez-Rojas, Elena, Menéndez, Juan José, Verdú, Cristina, Gómez-Zamora, Ana, Schüffelmann, Cristina, Calderón-Llopis, Belén, Laplaza-González, María, Río-García, Miguel, Amores-Hernández, Irene, Rodríguez-Rubio, Miguel, de la Oliva, Pedro, Ruiz, Jose, Rosillo, Sandra, González, Oscar, Iniesta, Angel, Ponz, Ines, Muñoz-Ramón, José María, Hernández-Gancedo, María, Uña Orejón, Carmen R., Sanabria-Carretero, Pascual, Moreno Gómez-Limón, Isidro, Seiz-Martinez, Alverio, Guasch-Arévalo, Emilia, Martín-Carrasco, Cristina, Alvar, Elena, Serrá, Lucía, Iannuccelli, Fabricio, Latorre, Julieta, Casares, Sandra, Valbuena, Isabel, Díaz Díez Picazo, Luis, Rodríguez Roca, Cristina, Cervera, Omar, García de las Heras, Esteban, Durán, Pilar, Castro, Carmen, Manrique de Lara, Carlos, Veganzones, Javier, López-Tofiño, Araceli, Fernandez-Cerezo, Estefanía, Zurita, Sergio, López-Martinez, Mercedes, Prim, Teresa, Alvárez del Vayo, Julía, Alcaraz, Gabriela, Castro, Luis, Yagüe, Julio, Díaz-Carrasco, Sofía, González-Pizarro, Patricio, Montero, Ana, Sagra, Francisco Javier, Suárez, Alejandro, Díez-Porres, Leyre, Varela-Cerdeira, María, Alonso-Babarro, Alberto, Abellán Martínez, Francisco, Alonso-Eiras, Jorge Ignacio, Álvarez Brandt, Alejandra, Archinà, Martina, Arribas-Terradillos, Silvia, Baselga-Puente, Trinidad, Barco Núñez, Pilar, Barrera-López, Natalia Guadalupe, Barrera-López, Lorena, Bartrina-Tarrio, Andres, Bassani, Gemma, Betancort de la Torre, Paula, Blanco-Bartolomé, Irene, Blasco-Andres, Celia, Brieba-Plata, Lucía, Cadenas-Gota, Fernando, Carrera-Vázquez, Paloma, Cascajares-Sanz, Carlota, Catino, Arianna, Cavallé-Pulla, Raquel, Ceniza-Pena, Daniel, Conde-Alonso, Ylenia María, Currás-Sánchez, Laura, Daltro-Lage, Marcelo, Esteban-Romero, Ana, Fernández Vidal, María Luisa, Ferrer Ortiz, Inés, de la Fuente Regaño, Lydia, Galindo-Ballesteros, Pablo, Garcia-Bellido Ruiz, Sara, García-Mochales Fortún, Carlos, Gómez-Ballesteros, Teresa, Gómez-Domínguez, Cecilia, González-Aguado, Nelsa, González-García, Sofía, Guisández Martín, Jorge, Hernández-Liebo, Paula Alejandra, Hernando Nieto, Raquel, Llorente-Cortijo, Irene María, Marín-García, Antonio, López-Pirez, Pilar, Mejuto-Illade, Lucía, Palma, Marco, Peña-Hidalgo, Adrian, Platero-Dueñas, Lucía, Pujol-Pocull, David, Ramírez-Verdyguer, Miguel, Redondo-Gutierrez, Marta, Reinoso-Lozano, Francisco, Rodríguez-Revillas, Ana, Rodríguez Saenz de Urturi, Alejandro, Romero-Imaz, Lucía, Sánchez-Rico, Susana, Sánchez-Santiuste, Mónica, Serrano de la Fuente, Patricia, Serrano-Martín, Henar, Silva-Freire, Thamires, Soria-Alcaide, Eva, Suárez-Plaza, Andrés Enrique, Tejero-Soriano, Beatriz, Torrecillas-Mainez, Andrea, Torres-Cortés, Javier, Valentín-Pastrana Aguilar, María de las Mercedes, Villanueva-Freije, Angélica, Virgós-Varela, Marta, Yagüe-Barrado, Marta, Yustas-Benitez, Natalia, Nuñez, María Concepción, Montserrat, Jaime, Queiruga, Javier, Rodriguez-Mariblanca, Amelia, Martínez de Soto, Lucía, Urroz, Mikel, Seco, Enrique, Zubimendi, Mónica, Stuart, Stephan, Díaz, Lucía, García, Irene, García Morales, María Teresa, Martín-Vega, Alberto, Caro, Abel, Martínez-Alés, Gonzalo, Gutiérrez-Gutiérrez, Belén, del Toro, María Dolores, Borobia, Alberto M, Carcas, Antonio, Jarrín, Inmaculada, Yllescas, María, Ryan, Pablo, Pachón, Jerónimo, Carratalà, Jordi, Berenguer, Juan, Arribas, Jose Ramón, and Rodríguez-Baño, Jesús

Published
2021
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23. Bisphenol-A Neurotoxic Effects on Basal Forebrain Cholinergic Neurons In Vitro and In Vivo

Author

Andrea Flores, Paula Moyano, Emma Sola, José Manuel García, Jimena García, María Teresa Frejo, Lucia Guerra-Menéndez, Elena Labajo, Inés Lobo, Luisa Abascal, and Javier del Pino

Subjects
bisphenol-A, basal forebrain, cholinergic neurons, synaptic plasticity, histone deacetylase 2, WNT/β-Catenin pathway, Biology (General), QH301-705.5
Abstract

The widely used plasticizer bisphenol-A (BPA) is well-known for producing neurodegeneration and cognitive disorders, following acute and long-term exposure. Although some of the BPA actions involved in these effects have been unraveled, they are still incompletely known. Basal forebrain cholinergic neurons (BFCN) regulate memory and learning processes and their selective loss, as observed in Alzheimer’s disease and other neurodegenerative diseases, leads to cognitive decline. In order to study the BPA neurotoxic effects on BFCN and the mechanisms through which they are induced, 60-day old Wistar rats were used, and a neuroblastoma cholinergic cell line from the basal forebrain (SN56) was used as a basal forebrain cholinergic neuron model. Acute treatment of rats with BPA (40 µg/kg) induced a more pronounced basal forebrain cholinergic neuronal loss. Exposure to BPA, following 1- or 14-days, produced postsynaptic-density-protein-95 (PSD95), synaptophysin, spinophilin, and N-methyl-D-aspartate-receptor-subunit-1 (NMDAR1) synaptic proteins downregulation, an increase in glutamate content through an increase in glutaminase activity, a downregulation in the vesicular-glutamate-transporter-2 (VGLUT2) and in the WNT/β-Catenin pathway, and cell death in SN56 cells. These toxic effects observed in SN56 cells were mediated by overexpression of histone-deacetylase-2 (HDAC2). These results may help to explain the synaptic plasticity, cognitive dysfunction, and neurodegeneration induced by the plasticizer BPA, which could contribute to their prevention.

Published
2023
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24. Paleogenetic evidence of a Pyrenean Neolithic family: Kinship, physical appearance and biogeography multidisciplinary analysis

Author

Gomes, Cláudia, Remolins, Gerard, López-Parra, Ana María, Gibaja, Juan F., Fondevila, Maria, De Angelis, Flavio, Veltre, Virginia, Subirà, M. Eulàlia, Baeza-Richer, Carlos, Guerrero, Diana, Palomo-Díez, Sara, Martínez-Labarga, Cristina, Labajo-González, Elena, Lareu, Maria Victoria, Perea-Pérez, Bernardo, and Arroyo-Pardo, Eduardo

Published
2020
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28. Maternal Lineages during the Roman Empire, in the Ancient City of Gadir (Cádiz, Spain): The Search for a Phoenician Identity

Author

Cláudia Gomes, Carlos González Wagner, Manuel Calero-Fresneda, Sara Palomo-Díez, César López-Matayoshi, Inês Nogueiro, Ana María López-Parra, Elena Labajo González, Bernardo Perea Pérez, José María Gener Basallote, Juan Miguel Pajuelo, and Eduardo Arroyo Pardo

Subjects
Phoenicians, Iberia Peninsula, maternal lineage, mtDNA sequencing, kinship, Social Sciences
Abstract

Phoenicians were probably the first eastern Mediterranean population to establish long-distance connections with the West, namely the Iberian Peninsula, from the final Bronze to the early Iron Age. For a long time, these colonies all over the Mediterranean Sea directly depended on an important city administration, Gadir, the most important metropolis in the Western Mediterranean. Modern archaeological excavations were discovered in Cadiz (Spain), the ancient city of Gadir, as well as possible Phoenician burial places. The purpose of the present work is the molecular study of 16 individuals, (V–IV millennium B.C, V A.D.) from several burial places found in Cadiz, attempting to disclose their maternal biogeographical ancestry. Furthermore, the determination of a possible biological link between two individuals found buried together was also an objective of this investigation. Of all the 16 analyzed individuals, eight of them produced positive results. Three main lineages were found: HV0, H and L3b. In general, the results support an Eastern origin for this set of individuals, reinforcing the theory of a Phoenician origin. Due to their historical period, in some cases, it was not possible to discard a Roman origin. Finally, the maternal kinship between two individuals found buried together was discarded.

Published
2023
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29. forenCAPS: Modelos 3D del Laboratorio de Antropología y Odontología Forense al servicio de la docencia Universitaria

Author

Benito Sánchez, María, García Velasco, María, Labajo González, Elena, Lescure Rodríguez, Javier, Mansour, Cindy, Mourin Moral, Fco. Javier, Perea Perez, Bernardo, Rascón Risco, Mónica, Santiago Saez, Andrés Santiago, Villoria Rojas, Catherine Pilar, Benito Sánchez, María, García Velasco, María, Labajo González, Elena, Lescure Rodríguez, Javier, Mansour, Cindy, Mourin Moral, Fco. Javier, Perea Perez, Bernardo, Rascón Risco, Mónica, Santiago Saez, Andrés Santiago, and Villoria Rojas, Catherine Pilar

Published
2024

30. Refugios Temporales en Oaxaca, México: Respuesta al Terremoto de Septiembre 2017

Author

Labajo González, Elena, Treviño Berlanga, Santiago, Labajo González, Elena, and Treviño Berlanga, Santiago

Abstract

En el trabajo de fin de máster se abordará la temática de todo lo que abarca un desastre natural; desde el fenómeno en sí, hasta los fenómenos culturales, el lenguaje, la idiosincrasia y la historia local. Más allá de la temática, se hablará de fenómenos específicos y se plantean puntos de cómo implementar ayuda humanitaria en situaciones complejas. Se dará como ejemplo de caso el estado de Oaxaca uno de los más pobres y políticamente activos en México contando con puntos concretos para facilitar la implementación de cualquier proyecto. Por último, se hablará sobre aprendizaje en campo a través de organizaciones sin fines de lucro., In this Master's Dissertation we will see how a natural phenomenon that creates a disaster itself is not the only factor that needs to be taken into account. There are important factors to consider such as language barrier, local history and cultural phenomena. There will be step by step point to make it easier and more plausible to give humanitarian aid in complex situations, in this particular case Oaxaca, one of Mexico's poorest states, and politically active, to ease any project for humanitarian aid that might come into order with a Non-Governmental Organization.

Published
2024

31. Caracteres epigenéticos de la morfogénesis y el desarrollo : patrón de expresión de los rasgos discretos en el esternón y la columna vertebral en España y Portugal

Author

Irurita Olivares, , Javier, Labajo González, Elena, Benito Sanchez, María, Villoria Rojas, Catherine del Pilar, Irurita Olivares, , Javier, Labajo González, Elena, Benito Sanchez, María, and Villoria Rojas, Catherine del Pilar

Abstract

Los rasgos discretos presentes en el esternón y la columna vertebral son herramientas valiosas para el estudio de las relaciones biológicas entre poblaciones y sus tendencias microevolutivas. Sin embargo, hay dificultad para identificarlos debido a la variedad de nombres y definiciones en la literatura. A pesar de las publicaciones que describen sus diferencias fenotípicas, no hay estudios que describan toda su variabilidad dentro de una misma población.., The discrete traits present in the sternum and spine are valuable tools for the study of biological relationships between populations and their microevolutionary trends. However, there is difficulty in identifying them due to the variety of names and definitions in the literature. Despite the publications that describe their phenotypic differences, there are no studies that describe all their variability within the same population...

Published
2024

32. Paleogenetic evidence of a Pyrenean Neolithic family: Kinship, physical appearance and biogeography multidisciplinary analysis

Author

Lopes Gomes, Claudia Filipa, Gerard Remolins, López Parra, Ana María, Baeza Richer, Carlos, Guerrero, Diana, Palomo Díez, Sara, Labajo González, Elena, Perea Pérez, Bernardo, Arroyo Pardo, Eduardo, Lopes Gomes, Claudia Filipa, Gerard Remolins, López Parra, Ana María, Baeza Richer, Carlos, Guerrero, Diana, Palomo Díez, Sara, Labajo González, Elena, Perea Pérez, Bernardo, and Arroyo Pardo, Eduardo

Abstract

Se trata del estudio genético de relaciones familiares más antiguo hasta la fecha en la Península Ibérica, mediante la utilización de marcadores genéticos y software forenses de uso convencional. Igualmente, se aporta información relevante sobre el aspecto físico de los neolíticos del Pirineo, cosa no realizada hasta el momento (2020). Es el resultado de una intensa colaboración nacional e internacional con el Grupo de Genética Forense y Genética de Poblaciones de la Facultad de Medicina de la Universidad Complutense, dirigido por los Drs. Eduardo Arroyo-Pardo y la Dra. Ana M. López-Parra., One of the most important Neolithic necropolises in the north-east of the Iberian Peninsula is La Feixa del Moro (3975-3790 cal. BC), located at 1335 mamsl in the Pyrenees (Juberri, Sant Julia de Lòria, Andorra). Within the scarcity of multiple simultaneous Neolithic burials, the main importance of La Feixa del Moro lies in the fact that it is one of the very few cases to suggest a biological family burial, comprising two adults and a newborn baby. Accordingly, the purpose of the present work was the multidisciplinary interpretation of the necropolis in the Neolithic context of the Pyrenees, on a potential route between the Iberian Peninsula and Europe. Therefore, kinship and biogeographic analyses were performed, as well as external visible characteristics phenotyping. Our results suggest the possibility of a traditional nuclear family, pointing to a very probable relation between the newborn and both adults. First, two mitochondrial haplotypes and two lineages were determined: H1, for the presumable mother and newborn, and U5, for the presumed father. Second, regarding their physical appearance, they all had brown eyes, the adult female and the neonate had dark brown hair, while the adult male's hair was dark red-brown. Finally, it was possible to confirm the sex of two of the individuals, as the newborn baby gender was also confirmed by the High Troughoutput Sequencing analysis. The multidisciplinary analysis of the La Feixa del Moro burial place envisions a very probable familial burial. Not only does the genetic evidence point to biological kinship, but also the archaeological record indicates a habitational area surrounding the burial site. The similar artefacts and the care shown during the funerary ritual suggest a probable biological Neolithic family., Una de las necrópolis neolíticas más importantes del noreste de la Península Ibérica es La Feixa del Moro (3975-3790 cal. a. C.), situada a 1335 m sobre el nivel del mar en los Pirineos (Juberri, Sant Julià de Lòria, Andorra). Dentro de la escasez de múltiples enterramientos neolíticos simultáneos, la principal importancia de La Feixa del Moro reside en que es uno de los pocos casos que sugiere un entierro familiar biológico, compuesto por dos adultos y un recién nacido. En este sentido, el objetivo del presente trabajo fue la interpretación multidisciplinar de la necrópolis en el contexto neolítico del Pirineo, en una potencial ruta entre la Península Ibérica y Europa. Para ello, se realizaron análisis de parentesco y biogeográficos, así como fenotipado de características externas visibles. Nuestros resultados sugieren la posibilidad de una familia nuclear tradicional, apuntando a una relación muy probable entre el recién nacido y ambos adultos. En primer lugar se determinaron dos haplotipos mitocondriales y dos linajes: H1, para la presunta madre y el recién nacido, y U5, para el presunto padre. En segundo lugar, en cuanto a su apariencia física, todos tenían ojos marrones, la hembra adulta y el neonato tenían cabello castaño oscuro, mientras que el cabello del macho adulto era marrón rojizo oscuro. Finalmente, fue posible confirmar el sexo de dos de los individuos, ya que el sexo del recién nacido también fue confirmado mediante el análisis de secuenciación de alto rendimiento. El análisis multidisciplinar del lugar de enterramiento de La Feixa del Moro vislumbra un enterramiento familiar muy probable. No sólo la evidencia genética apunta a un parentesco biológico, sino que también el registro arqueológico indica un área habitacional que rodea el sitio de enterramiento. Los artefactos similares y el cuidado mostrado durante el ritual funerario sugieren una probable familia biológica neolítica., Santander-Universidad Complutense de Madrid, Ministerio de Ciencia, Innovación y Universidades, Depto. de Medicina Legal, Psiquiatría y Patología, Fac. de Medicina, TRUE, pub

Published
2024

33. Spanish allele and haplotype database for 32 X-chromosome Insertion-Deletion polymorphisms

Author

Lopes Gomes, Claudia Filipa, Baeza Richer, Carlos, Palomo Díez, Sara, López Parra, Ana María, Labajo González, Elena, Perea Pérez, Bernardo, Arroyo Pardo, Eduardo, Lopes Gomes, Claudia Filipa, Baeza Richer, Carlos, Palomo Díez, Sara, López Parra, Ana María, Labajo González, Elena, Perea Pérez, Bernardo, and Arroyo Pardo, Eduardo

Abstract

X-chromosome markers have been proved to be decisive both complementing and solving kinship analysis, particularly when autosomal markers are not able to produce adequate likelihood ratios between different hypothesis. On the other hand, Pereira et al., (2012) have demonstrated that 32 Insertion/Deletion (InDel) markers located on the X-Chromosome have a very important power of discrimination in human populations, being a novel tool in the forensic and population fields. So, the aim of the present work was testing the forensic and population genetic efficiency of the 32 X-InDel polymorphisms in the Spanish population, and subsequently build an allele/haplotype frequencies database. To accomplish this objective, a total of 555 samples comprising male individuals from 13 Spanish regions were analysed for the above mentioned 32 X-InDels in two independent laboratories. A pairwise FST analysis was performed in order to understand if the studied Spanish sub-populations present significant differences among them, detecting possible population substructure. Also, linkage disequilibrium analyses were computed to investigate the presence of association between markers in the Spanish population. After Bonferroni correction, the absence of significant differences among the studied regions supports a global Spanish population database. Concerning LD, besides previously reported linked markers MID356-MID357 and MID3690-MID3719-MID2089, we also detected significant association between MID3703-MID3774, even after Bonferroni correction. Finally, after computing allele and haplotype frequencies, forensic efficiency parameters were calculated (PDmales = 99.999976 %; PDfemales = 99.99999999998 %). Mean exclusion chance values for duos were 0.999 and trios 0.99999. These results reinforce the suitability of the 32 X-InDels marker set both in identification and kinship studies., Santander-Universidad Complutense de Madrid, MINECO, Depto. de Medicina Legal, Psiquiatría y Patología, Fac. de Medicina, TRUE, pub

Published
2024

44. Anal Dysplasia Screening in People Living with HIV: Long-Term Follow-Up in a Large Cohort from Northwest Spain

Author

Pérez-González, Alexandre, primary, Rodríguez-Rivero, Silvia, additional, Fernández-Veiga, Pilar, additional, Flores, Erene, additional, Poveda, Eva, additional, González-Carreró, Joaquín, additional, Pérez-Castro, Sonia, additional, Labajo-Leal, Laura, additional, Miralles, Celia, additional, and Ocampo, Antonio, additional

Published
2023
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50. Surgical treatment for colorectal cancer: analysis of the influence of an enhanced recovery programme on long-term oncological outcomes—a study protocol for a prospective, multicentre, observational cohort study

Author

Javier Ripollés-Melchor, Ane Abad-motos, Alfredo Abad-gurumeta, Jose-M Ramirez-Rodriguez, Javier Martinez-Ubieto, Jose-L Muñoz-Rodes, Jose-R Rodriguez-Fraile, Jose-A Garcia-Erce, Javier Blanco-Gonzalez, Emilio Del Valle-Hernandez, Eugenia Centeno-Robles, Carolina Martinez-Perez, Miguel Leon-Arellano, Estibaliz Echazarreta-Gallego, Manuela Elia-Guedea, Ana Pascual-Bellosta, Elena Miranda-Tauler, Alba Manuel-Vazquez, Enrique Balen-Rivera, David Alvarez-Martinez, Jose Perez-Peña, Elisabeth Redondo-Villahoz, Elena Biosta-Perez, Hector Guadalajara-Labajo, Cristina Latre-Saso, Elena Cordoba-Diaz de Laspra, Luis Sanchez-Guillen, Mercedes Cabellos-Olivares, Javier Longas-Valien, Sonia Ortega-Lucea, Julia Ocon-Breton, Antonio Arroyo-Sebastian, and Damian Garcia-Olmo

Subjects
Medicine
Abstract

Introduction The evidence currently available from enhanced recovery after surgery (ERAS) programmes concerns their benefits in the immediate postoperative period, but there is still very little evidence as to whether their correct implementation benefits patients in the long term. The working hypothesis here is that, due to the lower response to surgical aggression and lower rates of postoperative complications, ERAS protocols can reduce colorectal cancer-related mortality. The main objective of this study is to analyse the impact of an ERAS programme for colorectal cancer on 5-year survival. As secondary objectives, we propose to analyse the weight of each of the predefined items in the oncological results as well as the quality of life.Methods and analysis A multicentre prospective cohort study was conducted in patients older than 18 years of age who are scheduled to undergo surgery for colorectal cancer. The study involved 12 hospitals with an implemented enhanced recovery protocol according to the guidelines published by the Spanish National Health Service. The intervention group includes patients with a minimum implementation level of 70%, and the control group includes those who fail to reach this level. Compliance will be studied using 18 key performance indicators, and the results will be analysed using cancer survival indicators, including overall survival, cancer-specific survival and relapse-free survival. The time to recurrence, perioperative morbidity and mortality, hospital stay and quality of life will also be studied, the latter using the validated EuroQol Five questionnaire. The propensity index method will be used to create comparable treatment and control groups, and a multivariate regression will be used to study each variable. The Kaplan-Meier estimator will be used to estimate survival and the log-rank test to make comparisons. A p value of less than 0.05 (two-tailed) will be considered to be significant.Ethics and dissemination Ethical approval for this study was obtained from the Aragon Ethical Committee (C.P.-C.I. PI20/086) on 4 March 2020. The findings of this study will be submitted to peer-reviewed journals (BMJ Open, JAMA Surgery, Annals of Surgery, British Journal of Surgery). Abstracts will be submitted to relevant national and international meetings.Trial registration number NCT04305314.

Published
2020
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